INTRODUCTION

Know how and what are

the bases of the central

dogma leads us to

interpret the significance

of the genetic

code

New alterations of genetic

information are becoming

more common and difficult

to correct , for that

every day there are

more studies on the

expression of genetic

Forget the selfish gene: Evolution

of life is driven by the selfish

ribosome, research suggests

January 7, 2015

Aarhus University

Forget the selfish gene: Evolution

of life is driven by the selfish

ribosome, research suggests

New research challenges this idea,

proposing instead that if anything is

'selfish' it must be the ribosome.

, Dr. Meredith Root-Bernstein, Aarhus

University, Denmark, and Dr. Robert Root-

Bernstein, Michigan State University, USA,

provide evidence that the question should

rather be answered with the word: Ribosomes.

Forget the selfish gene: Evolution of

life is driven by the selfish ribosome,

research suggests

The ribosome is a large

and complex molecule

found in all living cells. It

contains the machinery for

translating the genetic

information from DNA into

the proteins that perform

all the work of the cell and

make up most of its

structure.

Forget the selfish gene: Evolution of

life is driven by the selfish ribosome,

research suggests

The selfish ribosome model

closes a big theoretical gap

between, on the one hand, the

simple biological molecules that

can form on mud flats, oceanic

thermal vents or via lightning,

and on the other hand LUCA, or

the Last Universal Common

Ancestor, a single-celled

organism.

“We're all

homes to

ribosomes”.

Dr. Meredith

Root-Bernstein

Personal Comment

Investigations of the central dogma of

genetic information and how was the

beginning of the cell has led to new

discoveries that may be of great

importance in progress in medicine

and molecular biology from the

beginning because if we know how

something works and what was the

origin we can approach the genetic

problems from other perspectives that

before they looked impossible.

Tight packing in shell leaves viruses

vulnerable

January 6, 2015

International

School of

Advanced Studies

(SISSA)

Tight packing in shell leaves viruses

vulnerable

A study, in which the International School for Advanced

Studies (SISSA) collaborated with the Josef Stefan Institute

of Ljubljana, analysed how genome mutations of RNA

viruses tend to be lethal for these infectious agents.

Tight packing in shell leaves viruses

vulnerable

The scientists expected a fairly

mild effect but their

observations demonstrated

the opposite. "Using computer

simulations, we produced what

might be considered minor

mutations, known as

'synonymous' mutations, and

so we were expecting them to

have a small effect on

packaging," explains Tubiana.

Tight packing in shell leaves viruses

vulnerable

Synonymous mutations change the

composition of RNA but not the proteins it

synthesizes. These mutations cause

changes in a codon, although were small

changes the consequences on packing

were dramatic

Personal Comment

Its very important the advance and the

evolution that tecnology and medicine

have currently and in this investigation

we can observe it very well because

of the change in the dogma of some

bacterias especifically in the RNA

caused by the codones and all the

changes that it inmplies, this can be

important for the solution of many

infectious diseases.

Medical Utility

Medical Utility Central dogma studies are very

important in medical practice because it

helps from the early foundations of life to

the prevention and cure of genetic

diseases that can be mortal

Medical Utility Discover how to disable the function of virus will

be a great medical advance because they could

find a cure for diseases with high mortality or that

can be very destructive to the patient who has it

because the virus may modify the genetic

information and could affect other generations.

Medical Utility All past studies on genetic information

speak to the structural and functional basis

is the DNA but some new studies as

presented in the Aarhus University show

other theories that point as the start the

ribosomes, it is very interesting contribution

because if structuring is changed a theory

can handle different genetic problems from

another perspective

Bibliography

International School of Advanced Studies

(SISSA). January 6, 2015. Tight packing in shell

leaves viruses vulnerable. Science daily.

http://www.sciencedaily.com/releases/2015/01/150

106081219.htm

• Aarhus University. January 7, 2015. Forget the

selfish gene: Evolution of life is driven by the

selfish ribosome, research suggests. Science

daily.http://www.sciencedaily.com/releases/2015

/01/150107101405.htm

• MARTINEZ S. Lina María. Biología Molecular.

7. Ed. Medellín: UPB. Fac. de Medicina, 2012.

292 p

Thanks