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This presentation contains certain forward-looking statements. Thesestatements relate to future events or future performance and reflectmanagement’s expectations and assumptions regarding growth,results of operations, performance and business prospects andopportunities. Such forward-looking statements reflectmanagement’s current beliefs and are based on informationcurrently available to management.
A number of factors could cause actual events to differ materially. Inevaluating these statements, prospective purchasers shouldspecifically consider various risks as more fully outlined in theprospectus, a copy of which can be obtained online atwww.sedar.com.
Forward Looking Statements
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Skin cancer strikes 1 in 5 in the U.S.1
It is the most common form of cancer
40-50% of Americans who live to 65 expected to get skin cancer 2
Melanoma kills one person every hour in the US 3
Melanoma is the #1 cancer killer of women 25-30 4
Incidence of melanoma rising faster than any other cancer 5
- Howard Rogers, Dermatologist, Lead on Medicare research“There’s an epidemic of skin cancer”
3
Melanoma is DeadlyAccounts for 75% of skin cancer deaths6
4
Early detection vital to saving lives
0
20
40
60
80
100 95% Melanoma Five Year Survival Rate by Tumor Stage 6
15%
Stage I Stage II Stage III Stage IV
5
2 million Americans get skin cancer each year 7
Treating melanoma alone costs $1.5 billion annually in the U.S. 8
Advanced stage melanoma 22 times more costly to treat than early stage
Early detection would save billions of dollars
5.011.0 13.7
22.5 24.3
35.4 38.3
105.5110.1
Cost of Treating Melanomaby Tumor Stage (per patient) 9
Early Stage Late Stage
($ US thousands)
6
Primary diagnosis done by GPs with varying levels of experience
Full body examinations seldom conducted
33.8% sensitivity for melanoma for GPs 10
› Squamous Cell Carcinoma – 41.1%
› Basal Cell Carcinoma – 63.9%
Biopsies invasive and costly
› Permanent scarring
~80% of biopsies test negative 11
Current skin cancer detection methods limited
Clinical Diagnosis
Punch Biopsy
Histological Diagnosis
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Detects melanoma with 97% accuracy vs. 33.8% for primary clinical diagnosis
Developed by BC Cancer Agency and UBC
Patented technology
Exclusively licensed to Verisante Technology, Inc.
Initial Focus: Early detection of skin cancerBreakthrough early stage cancer detection system
All forms of
Skin Cancer
Gastrointestinal,
Lung, and Cervical
Cancers
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Skin cancer: Verisante AuraTM
Highly automated detection process
Near Infrared Raman Spectroscopy
Handheld probe scansfor 21 biomarkers inan instant
Rapid speed enablesfull body scans
Provides data on chemical composition of skin based on molecular vibrations
Differentiates betweenmalignant and benign tissue
Pathology on every lesion scanned
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Skin cancer: Verisante AuraTM
Highly automated detection process
Safe, Non-invasive, Fast
Real time results97% accurate for melanoma91% for other skin cancers
Increased survival rates
Reduced treatment costs
No unnecessary biopsies
Reduced waiting times
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6 year clinical study at Vancouver General Hospital’s Skin Care Center
Focused on differentiating cancerous lesions from benign lesions
1,000 skin lesions scanned
Preliminary results published in 2008 based on 274 lesions 12
Skin cancer: Verisante AuraTM
Proven in clinical trials by the BC Cancer Agency
Melanoma
97% sensitivity“Percentage identified”
78% specificity“Confirmed by biopsy”
Cancerous and Precancerous Lesions
91% sensitivity“Percentage identified”
75% specificity“Confirmed by biopsy”
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Verisante Aura™
Proven technology
Detects all skin cancers
97% Sensitivity; 78% Specificity for melanoma
Measures 21 biomarkers
Virtually instant scan
Non-invasive
Tiny Probe
Inexpensive disposable covers
Superior technology over competing systems
Scibase Inc.
• Electrical Impedance Spectroscopy• 98% sensitivity; specificity < 5% • Slightly invasive• 5 minutes per lesion• Large probe/expensive disposables
Mela Sciences
• Computerized Imaging Technology• FDA Panel recommends approval by narrow margin• Key Concern: too many false positives• 98% sensitivity; 9.5% specificity• Large probe
Lucid Inc.
• Confocal Microscopy• 10-20 min. per lesion• Dermatologist required• Large probe
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Clinical studies underway at VGH for early detection of lung & colon cancer
Lung Cancer 13
World’s #1 cancer killer with
1.4 million deaths/year
Colon Cancer
#2 deadliest cancer in U.S.
Cervical Cancer
World’s #2 cause of cancer
deaths among women
Verisante CoreTM
Endoscopic system enables detection of other cancers
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Dr. Branko PalcicPh.D.
• Honorary Professor, Dept. of Pathology and Laboratory Medicine, UBC
• Founder, Cancer Imaging and Technology Departments, BC Cancer Agency
• Co-inventor of LIFE-Lung device, used in over 150 major medical centers world-wide
• Friesen-Rygiel Award for Outstanding Canadian Academic Discovery (1999)
• King George V Silver Jubilee Cancer Research Fellow
Dr. Haishan ZengPh.D.
• Senior Scientist, Integrative Oncology Dept. BC Cancer Agency
• Associate Professor, Dermatology and Skin Science, University of British Columbia
• Co-inventor - Verisante™ technology
Focused on developing systems for the early detection of cancerStrong scientific pedigree
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Dr. David McLeanMD, FRCPC
• Professor, Dept. of Dermatology and Skin Science, UBC
• President, Cancer Prevention Institute of Canada
• Former President, Canadian Dermatology Association
• Co-inventor - Verisante™ technology
Dr. Harvey LuiMD, FRCPC
• Professor and Head, Dept. of Dermatology and Skin Science, UBC
• Former Clinical Fellow, Massachusetts General Hospital, Harvard Medical School
• University Killam Prize (2001)
• Co-inventor - Verisante™ technology
Focused on developing systems for the early detection of cancerStrong scientific pedigree
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Skin cancer: Verisante AuraTM
Clear regulatory pathway to commercialization
2010 2011 2012 2013 2014 2015
Marketing and Sales (Canada)
Marketing and Sales (EU, South Africa, Australia)
Marketing and Sales (USA)
Production Prototype & Health Canada Approval
CE Mark
Clinical Study Prep.
ApprovalClinical StudyUSA
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Skin cancer: Verisante AuraTM
Significant market potential with multiple end users
Canada
USA
EU
South Africa
AustraliaNZ
Initial Geographic MarketsRecurring revenue from sale of disposable probe shields
Staged Rollout Strategy
STEP 1
Early adopters~32,000 Dermatologists
STEP 2
Innovators~950,000 General Practitioners
STEP 3
Skin Care ClinicsOncology and Imaging Clinics
HMOs
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Will drive broader market acceptanceInitial focus on early adopters and innovators
0
400
800
1200
1600
2000
Yr. 1 Yr. 2 Yr. 3 Yr. 4 Yr. 5
Targeting 14% penetration by year 5 Dermatologists
Canada, European Union, South Africa, Australia, New Zealand
United States
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Will drive broader market acceptanceInitial focus on early adopters and innovators
General Practitioners
Canada, European Union, South Africa, Australia, New Zealand
United States
0
5000
10000
15000
20000
25000
30000
35000
Yr. 1 Yr. 2 Yr. 3 Yr. 4 Yr. 5
Targeting 6% penetration by year 5
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Thomas BraunBA, JD, LLM – Chief Executive Officer
• Public company experience
• Extensive experience in executing M&As and raising capital
• Advised high tech companies on international business transactions
• Expertise in technology licensing
• Member California Bar Association
Anna TrinhB.Comm, LLB – Chief Financial Officer and Corporate Counsel
• Experience in counseling companies on regulatory and compliance filings
• M&A and financial transaction experience
• Practiced corporate securities law in private practice
Focus: controlling costs, accelerating product development & regulatory approval processExperienced management
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Joe BiegelBS, MS (Medical Imaging)
• Vice-President, Product Management & Marketing
• McKesson Medical Imaging Group
• Senior positions with Agfa Healthcare, Hewlett Packard, Polaroid Medical Imaging
Karen BoodramBSc, MBA
• Vice-President, Business Development, SemBiosys
• Former Life Sciences Analyst, PI Financial
• More than 25 years healthcare experience
• Ten years with Novartis
Strong, independent Board of Directors
Chris DennisMBA
• Former President, Comcare Health Services
• Senior positions with AngiotechPharmaceuticals, Johnson & Johnson / Ortho Neutrogena
Jake ThiessenPh.D.
• Professor Emeritus, University of Toronto
• Founding Director, School of Pharmacy and Health Sciences Campus, University of Waterloo
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Share Capital
Common Shares 46,188,117
Common Shares (held by Founders) 14,700,000
Total Common Shares Outstanding 60,888,117
Warrants 17,568,600
Incentive Stock Options 3,545,000
Fully Diluted Share Capital 82,001,717
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Market Comparables
Company Market Capitalization
MELA Sciences, Inc. (NASDAQ: MELA) $93,000,000
Novadaq (TSX: NDQ) $126,000,000
ALI Technologies Inc. *Sold to McKesson (NYSE: MCK) in 2002 for $530 Million
$530,000,000
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Breakthrough early stage skin cancer detection device
Patented technology with exclusive worldwide license from BC Cancer Agency
Clear regulatory pathway to commercialization with significant market potential
Endoscopic device for early stage detection of lung, colon and cervical cancers in clinical trials
Strong scientific pedigree and experienced management
Summary
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ReferencesEnd Notes
1. American Cancer Society. Cancer Facts & Figures 2009
2. National Cancer Institute. Cancer Trends Progress Report 2007, Update April 2008
3. American Cancer Society. Cancer Facts and Figures 2009
4. Melanoma Research Foundation
5. National Cancer Institute. SEER Cancer Statistics Review, 1975-2004
6. National Center for Chronic Disease Prevention and Health Promotion
7. Rogers HW, Weinstock MA, et al. Incidence Estimate of Non Melanoma Skin Cancer in the U.S., 2006, Archives of Dermatology 2010
8. National Cancer Institute. Cancer Trends Progress Report 2007
9. Doru Traian Alexandrescu. Melanoma Costs: A Dynamic Model Comparing Estimated Overall Costs of Various Clinical Stages,
Dermatology Online Journal, Nov 2009
10. Heal CF, Raasch BA, Buettner PG, Weeden D. Accuracy of Clinical Diagnosis of Skin Lesions, British Journal of Dermatology 2009
11. Jones TP, Boiko PE, Piepkorn MW. Skin biopsy indications in primary care practice: a population-based study. JABFP 1996; 9:397–404.
12. Raman Spectroscopy for In Vivo Tissue Analysis and Diagnosis, Instrument Development to Clinical Applications, Journal of
Innovation in Optical Health Sciences 2008
13. Cancer Research UK
14. National Cancer Institute. SEER Database, 1998 – 2000
15. Melamed MR, Flehinger BJ, Zamen MB, et al. Screening for early lung cancer: results of the Memorial Sloan-Kettering study In New
York. Chest 86:44-53, 1984.
16. Cortese DA, Pairolero PC, Bergstralh EJ, et al. Roentgenographically occult lung cancer. A ten-year experience. J Thorac Cardiovasc
Surg 86:373—80, 1983
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Thank you