Psoriasis - Identifying and Commercializing First-in-Class Innovation

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Frontier Pharma: Psoriasis -

Identifying and Commercializing

First-in-Class Innovation

Category : Pharma & Healthcare

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Introduction to Report

Launch Date: June 30, 2014

Number of Pages: 77

Geography Coverage: Global

Available Format: PDF

Price For Single User License: USD 3,500

Price For Site User License: USD 7,000

Price For Global User License: USD 10,500

Delivery Time: Within 24 Hours (During Working Days)



About the Report

“Frontier Pharma: Psoriasis Identifying and Commercializing First-in-Class Innovation”, which identifies and assesses first-in-class innovation in the psoriasis development pipeline.

Despite mostly targeting established molecules, the psoriasis pipeline is showing a high level of innovation in first-in-class molecules, including novel angiogenic drugs, growth factors, chaperone proteins and cytokines, according to Frontier Pharma: Psoriasis - Identifying and Commercializing First-in-Class Innovation report.



Research Findings

This report states that first-in-class programs constitute an estimated 27% of the entire psoriasis pipeline, and are predominantly composed of targeted therapies, including cytokine and receptor modulators, nuclear receptor modulators and intracellular kinase inhibitors.

There are several novel therapies targeting first-in-class T cell antigens, thanks to a growing understanding of the signaling pathways underlying the psoriasis pathophysiology, in which T cells have been shown to play a substantial role in disease progression.

Therapies that can selectively modulate specific subsets of immune cells, without compromising the entire immune system, have become increasingly desirable, according to Publisher.



Research Findings Continues…

One such program is Tregalizumab, a humanized Cluster of Differentiation (CD) 4-specific monoclonal antibody.

In contrast to other anti-CD4 antibodies, Tregalizumab is able to activate the suppressive properties of regulatory T cells. It is currently in Phase II clinical trials for the treatment of rheumatoid arthritis and in Preclinical development for treating psoriasis.

Publisher states that although no preclinical or clinical efficacy data has been disclosed for the antibody, it has been involved in a lucrative co-development deal worth $480 million between Biotest and Abbott Laboratories.



Scope

A brief introduction to psoriasis, including symptoms, pathophysiology, and overview of pharmacotherapy

The changing molecular target landscape between market and pipeline and particular focal points of innovation

Overview of how innovative products are contributing to the pipeline and market for psoriasis

Comprehensive review of the pipeline for first-in-class therapies, analyzed on the basis of phase distribution, molecule type, molecular target, and administration route

Identification and assessment of first-in-class molecular targets with a particular focus on early-stage programs of which clinical utility has yet to be evaluated, as well as literature reviews on novel molecular targets



Reasons To Buy

Understanding of the focal shifts in molecular targets in the psoriasis pipeline

Understanding of the distribution of pipeline programs by phase of development, molecule type and molecular target

Scientific and clinical analysis of first-in-class developmental programs

Assessment of the valuations of licensed and co-developed psoriasis treatments

A list of the first-in-class therapies potentially open to deal-making opportunities.

Analysis of financial valuations on licensed or co-developed first-in-class therapies and generics



Report Coverage

1. The Case for Innovation2. Clinical and Commercial Landscape3. Assessment of Psoriasis Pipeline and Innovation4. First-in-Class Target and Pipeline Program Evaluation5. Deals and Strategic Consolidations6. Appendix

For more details regarding Report coverage see the last slide

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