Sebastián Calle Díaz

Molecular Biology 3° Semester

 

The globalization o f the world brings

itself the development of new technologyes and for instance positive consequences for the science . One example is the

extraction of biofuels; and the

identification own specific DNA

sequences of some pathologies.

• M. Taylor-Teeples, L. Lin, M. de Lucas, G. Turco, T. W. Toal, A. Gaudinier, N. F. Young, G. M. Trabucco, M. T. Veling, R. Lamothe, P. P. Handakumbura, G. Xiong, C. Wang, J. Corwin, A. Tsoukalas, L. Zhang, D. Ware, M. Pauly, D. J. Kliebenstein, K. Dehesh, I. Tagkopoulos, G. Breton, J. L. Pruneda-Paz, S. E. Ahnert, S. A. Kay, S. P. Hazen, S. M. Brady. An Arabidopsis gene regulatory network for secondary cell wall synthesis. Nature, 2014; DOI:10.1038/nature14099

This research was conducted in Arabidopsis thaliana model, which is used in molecular biology to study plant development

Explored how a large number of interconnected transcription factors regulate xylem and cell wall thickening

Allows the knowledge of the relationship between the polymers that give 

regulation  of  cell control wall thickening

This gives plants a huge number of 

possible combinations for responding and 

adapting to environment

most of the proteins including regulators 

of cell cycle and differentiation bind directly to genes

interconnected network of more 

than 240 genes and more than 600 protein-DNA interactions

 "understanding how the relative proportions of these biopolymers are controlled in plant tissue would open up opportunities to redesign plants for biofuel use."

The identification of this genetic control network possessing plants for wall thickness, allow to create increasingly specific the needs that arise when the extraction of biomass plants needed for biofuels; which facilitate the process, costs will decrease and thus may increase the use of these new fuels, thus reducing environmental pollution.  

• E. Schutz, M. R. Akbari, J. Beck, H. Urnovitz, W. W. Zhang, K. Bornemann-Kolatzki, W. M. Mitchell, R. K. Nam, S. A. Narod. Chromosomal Instability in Cell-Free DNA Is a Serum Biomarker for Prostate Cancer. Clinical Chemistry, 2014; 61 (1): 239 DOI: 10.1373/clinchem.2014.226571

The research picked up samples of more than 200 patients with prostate cancer and 200 controls over

The research found 20 points of chromosomic “inestability” relationship with tumoral cells.

The cells die and release the DNA

The new technology, 

specially "next-generation 

sequencing,"

distinguish and quantify  specific 

cancer- DNA

  This procedure is known as liquid biopsy, as it is non invasive and is able to distinguish tumor cell DNA. 

Makes evident the answer that has the patient to that treatment, measured in proportion to the number of dead cells. 

The development of new tecniques of diagnosis will give the possibility of less use of invasory tests and it could be more precise and efficient.  

The Reconnaissance network polymers that control the thickness of the cell wall of plants, facilitate the extraction process, costs will decrease and thus may increase the use of these new fuels; it will provide final results with the decrease of the high levels of pollution and diseases such as bronchitis, asthma, circulatory system diseases, lung cancer and genetic mutations that have been proven in close relation to pollution. 

Medical Utility

The utilization of new procedures such as biopsy liquid, allow for more effective diagnosis and decrease adverse events, such as the possibility to contaminated another tissues, at the moment to give extraction of Cells. 

Medical Utility

THANKS