“MUTA

TION R

ATES IN

CANCER C

ELLS

STR

ONGLY

LINKED

TO H

OW

CHROMATI

N IS

ORGANIZED

” A

ND

“DNA D

AMAGE

IN

ROOFERS D

UE TO

PAH

EXPOSURE,

POSS

IBLE

CANCER L

INK”

MA

TE

O A

RA

NZ

AZ

U U

RI B

E

ME

DI C

AL S

TU

DE

NT

AU

GU

ST

INTRODUCTION

cancer

Caused by chromatin

organization

Caused by exposition to risk factors

Can cause mutations on the

genome

Mutations will cause division

MUTATION RATES IN CANCER CELLS STRONGLY LINKED TO HOW CHROMATIN IS ORGANIZED

Cause mutations on the genome

Chromatin organizatio

n linked

Rare chromatin, higher mutation

In cancer cells

Cancer is a genetic desease

MUTATION RATES IN CANCER CELLS STRONGLY LINKED TO HOW CHROMATIN IS ORGANIZED

Many types of tissues were

studies

melanoma leukemia Prostate and lung cancer

And many types of cancer

MUTATION RATES IN CANCER CELLS STRONGLY LINKED TO HOW CHROMATIN IS ORGANIZEDTHIS KIND OF STUIDES

ARE ECONOMIC, BECAUSE THE INFORMATION WAS ALREADY TAKEN

THE INFORMATION IS AVILABLE AND FREE FOR EVERYBODY

THE INFORMATION ALLOWS TO KNOWM MORE ABOUT GENETICS DISEASES AS CANCER

MUTATION RATES IN CANCER CELLS STRONGLY LINKED TO HOW CHROMATIN IS ORGANIZED

objectiveEstablish a relationship beetwen how chromatin is organized and Cancer rates

MUTATION RATES IN CANCER CELLS STRONGLY LINKED TO HOW CHROMATIN IS ORGANIZED

PERSONAL COMMENT

ANY STUDY ABOUT CANCER AND ITS CAUSES CAN BE RELEVAN IN THE PROCES TO FIND A CURE, KNOWING ITS CAUSES, ORIGINS AND SOME MARKERS IS ESSENTIAL TO IMPROVE TREATMENTS AND MEDICINES

DNA DAMAGE IN ROOFERS DUE TO PAH EXPOSURE, POSSIBLE CANCER LINK

PHA Polycyclic aromatic hydrocarbons  are potent atmospheric pollutant As a pollutant, they are of concern because some compounds have been identified as carcinogenic, mutagenic, and teratogenic

DNA DAMAGE IN ROOFERS DUE TO PAH EXPOSURE, POSSIBLE CANCER LINK

ROOFERS AND ROADWORKERS ARE CONSTANTLY EXPOSED TO PHA, BUT ALSO ARE EXPOSED TO SMOKE, UV LIGHT, AND MORE CARCINOGENIC AGENTS THAT CAN INCREASE CANCER RATES IN THIS POPULATION

ALL OF THEM, CAUSE DAMAGE IN THE DNA

DNA DAMAGE IN ROOFERS DUE TO PAH EXPOSURE, POSSIBLE CANCER LINK

THE SAMPLES WERE TAKEN UNDER SOME STANDARDS AS:

acute exposure to hot asphalt

workers who didn't use protective gloves

workers who reported work related skin burns

DNA DAMAGE IN ROOFERS DUE TO PAH EXPOSURE, POSSIBLE CANCER LINK

PHAS ARE PRODUCED by incomplete combustion of organic materials

TOBACCO SMOKE

ENGINE EXHAUST

FOREST FIRES

ASPHALT OVENS

DNA DAMAGE IN ROOFERS DUE TO PAH EXPOSURE, POSSIBLE CANCER LINK

PERSONAL COMMENT

THIS STUDY COULD OPEN THE DOOR FOR FORMULATE NEW POLITICS AND FOR TAKE NEW BIOSECURITY RULES FOR THIS WORKERS, ALWAYS LOOKING FOR THE HEALTH AND FOR THE WELFARE OF THE PEOPLE

MEDICAL UTILITYMUTATION RATES IN CANCER CELLS

STRONGLY LINKED TO HOW CHROMATIN IS ORGANIZED

-KNOWING RELATIONSHIPS BETWEEN CHROMATIN AND MUTATIONS CAN PREVENT DESEASES, MAKING STUDIES ON PEOPLE WITH RISK BEFORE THEY DEVELOP THE DESEASE, GIVING THEM MEDICINE AS A PROFILACTIC MEASUREMENT

MEDICAL UTILITYMUTATION RATES IN CANCER CELLS

STRONGLY LINKED TO HOW CHROMATIN IS ORGANIZED

-BY KNOWIG THE CAUSES OF THE CANCER, FINDING A CURE ITS MORE EASY, AND KNOWING THE CAUSES IS ALSO VERY USEFUL TU KNEW TREATMENTS LESS AGRESSIVE THAN QUIMIO, FOR EXAMPLE

MEDICAL UTILITYDNA DAMAGE IN ROOFERS DUE TO PAH EXPOSURE, POSSIBLE CANCER

LINKIDENTIFY CARCINOGENIC SUSBTANCES IS REALLY IMPORTANT, FOR REGULATING THEIR PRODUCTION AND THEIR COMERCIALITATION IN SOME CASES, FOR PREVENTING DEVELOPING NEW DESEASES AS FATAL AS CANCER

MEDICAL UTILITYDNA DAMAGE IN ROOFERS DUE TO PAH EXPOSURE, POSSIBLE CANCER

LINK

SOME WORKS HAVE MORE RIKS THAN THE OTHERS, AND ITS VERY IMPORTANT KOWING THE CAUSE OF THE RISK AND WHAT IS PRODUCING THE RISK, SO THE WORKERS CAN FIND MEASUREMENTS TO PROTECT THEMSELVES AND TO PROTECT THE ENVIROMENT, FOR EXAMPLE, FINDING A WAY TO REDUCE TE EXPOSURE TO PHAS

BIBLIOGRAPHYDNA Damage in Roofers Due to PAH Exposure, Possible Cancer LinkScience Daily (July 26, 2012)   

Mutation Rates in Cancer Cells Strongly Linked to How Chromatin Is OrganizedScience Daily (July 26, 2012)   

MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 208 p.