Megaloblastic anemia in Pregnancy

  • View
    124

  • Download
    5

Embed Size (px)

Text of Megaloblastic anemia in Pregnancy

  1. 1. MEGALOBLASTIC ANEMIA SURJEET ACHARYA VMC
  2. 2. Objective INTRODUCTION EPIDEMIOLOGY PATHOGENESIS CAUSES CLINICAL FEATURES TREATMENT
  3. 3. Introduction Anemia due to - deficiency in Vitamin B12 - deficiency in Folic acid - disturbance in Folic acid metabolism
  4. 4. This is characterised by presence of - megaloblast - hypersegmented nuetrophil
  5. 5. INCIDENCE 0.5%-3% pregnant female (esp. Multigravida) VITAMIN B12 deficiency is RARE in PREGNANCY Normal folate store lasts for 6 weeks
  6. 6. PATHOGENESIS
  7. 7. receptor Into plasma
  8. 8. Deoxy thymidilate monophosphate
  9. 9. polyglutamates monoglutamate INTO PLASMA
  10. 10. CAUSES
  11. 11. VITAMIN B12 Vegeterian diet (not even milk and milk products)Inadequate intake Gastritis Gastrectomy Ileal bypass surgery Crohns disease Tumor of ileum PPH Malabsorption
  12. 12. FOLIC ACID Nausea, Vomiting, LOA Decreased dietary intake Inadequate intake Multiple pregnancy Growing fetus Increased demand Infection Anticonvulsant Failure of utilization Liver disorder Vitamin C deficiency Diminished storage Infection- hookworm, malaria, Hemorrhage- peptic ulcer, hemorrhoids Abnormal demand
  13. 13. Symptoms
  14. 14. Signs PALLOR GLOSSITISHEPATOSPLENOMEGALY
  15. 15. MCV increased MCH raised MCHC normal Lymphopenia, Thrombocytopenia Red cell folate