Krok 2 - 2011 Question Paper (Pharmacy)

Krok 2 Pharmacy 2011 1

1. During local anaesthetizati-on novocaine solution is usuallycompounded with solution of adrenalinehydrochloride. What is the purpose of thisaction?

A. VasoconstrictionB. VasodilatationC. Increase in smooth muscle toneD. Decrease in smooth muscle toneE. Algesthesia reduction

2. Which of the below-listed drugs isused for thrombolytic therapy in case ofmyocardial infarction?

A. StreptokinaseB. HeparineC. РhenylinumD. TiclopidineE. Acetylsalicylic acid

3. On the 4th day of treatment wi-th indometacin a 55-year-old patientdeveloped gastrorrhagia as a result ofgastric mucosa ulcer. Ulcerogenic effectof this drug is explained by the loweredactivity of the following enzyme:

A. Cyclooxygenase-1 (COX-1)B. Cyclooxygenase-2 (COX-2)C. Lipoxygenase (LOG)D. Prostacyclin synthetaseE. -

4. A 45-year-old patient has been taki-ng neodicumarinum for thrombophlebi-tis for two weeks. The regular bloodtest revealed a decrease in prothrombinconcentration, microhematuria. Whichdrug should be used as neodicumarinumantagonist?

A. VicasolB. Protamine sulfateC. Sodium citrateD. HeparinE. Aminocaproic acid

5. A patient complaining of dry mouth,photophobia and blurred vision has beendelivered to the admission ward. Objecti-vely: the skin is hyperemic, dry, mydriaticpupils and tachycardia are present. He hasbeen diagnosed with belladonna alkaloidsintoxication. Which of the drugs shouldbe given as an antidote?

A. NeostigmineB. AceclidineC. PylocarpineD. ArminE. Dipiroxim

6. A 52-year-old patient was diagnosedwith systemic amebiasis accompanied bybowels, liver and lungs affection. Whatpreparation should be administered?

A. MetronidazoleB. ChiniofonC. TetracyclineD. ChingaminE. Phthalazol

7. A gravida in her 20th week ofgestation got ill with pneumonia. Whatchemotherapeutical drug may be admi-nistered with no risk for the fetusdevelopment?

A. ВеnzylpenicillinumB. GentamycinC. SulfalenumD. LaevomycetinumE. Ofloxacinum

8. During a surgical operation the musclerelaxant tubocurarine chloride was used.What antagonist drug should be injectedin order to allow the patient to briefindependently?

A. NeostigmineB. DithylinumC. CytitonumD. AethimizolumE. Веnzohexonium

9. A pharmacy depot received a batch ofcommon plantain leaves. According to therequirements of the Pharmacopoeia, thisherbal raw matrial is of adequate quality ifit contains the following active substances:

A. PolysaccharidesB. FlavonoidsC. TanninsD. Anthracene derivativesE. Essential oils

10. A pharmacy analyst analizes distilledwater. For this purpose he brings someamount of the sample material to the boi-ling point, adds 0,02 M solution of potassi-um permanganate and diluted sulfuricacid. After 5 minutes of boiling the pi-nk colour of the produced solution shouldnot change. The pharmacy analyst tries todetect the following admixture:


A. Chemical reducing agentB. Carbon dioxideC. NitratesD. SulfatesE. Heavy metals

11. A pharmacy supplies the populationwith drugs for cash. Specify the VAT ondrugs:

A. 0%B. 10%C. 15%D. 20%E. 30%

12. Aerosol production involves appli-cation of different groups of propellents.What propellents relate to the group ofcompressed gases?

A. Nitrogen, nitrous oxide, carbon dioxideB. FreonsC. Propane, butane, isobutaneD. Vinyl chloride, methyl chlorideE. Methylene chloride, ethylene chloride

13. An analytical laboratory carriesout quantitative analysis of sodiumcitrate by method of ion-exchangingchromatography on a cationite. Whattitrated solution is to be used for thefollowing titration of generated citricacid?

A. Sodium hydroxideB. IodineC. Potassium iodateD. Hydrochloric acidE. Trilon B

14. Which preparation is the specific anti-dote in case of intoxication with ironpreparations?

A. DeferoxamiumB. Protamine sulphateC. BemegridumD. AtropinumE. Penicillamine

15. A pharmaceutist revealed incompati-bility in the formulation.Rp.: Sol. Collargoli 1% - 10 ml

Sol. Adrenalini hydrochloridi 0,1% - 1 mlM.D.S. Nasal drops.

What chemical process underlies thisincompatibility?

A. OxidizationB. NeutralizationC. PrecipitationD. HydrolysisE. Adsorption

16. A pharmaceutist made a tinctureof Adonis herb. A peculiarity of itspreparation is that the active substancesare derived in:

A. In the neutral mediumB. In the alkalescent mediumC. In the alkaline mediumD. In the subacid mediumE. In the acid medium

17. Coltsfoot preparations are usedfor upper airways treatment. Duringprocurement of this herbal raw materialthe following admixture may appear:

A. Great bur (Arctium lappa)B. Common plantain (Plantago major)C. Spring adonis (Adonis vernalis)D. Marsh mallow (Althaea officinalis)E. Pot marjoram (Origanum vulgare)

18. A pharmacist-technologist received anointment formulation.Rp.: Unguentum Resorcini 1,5% - 10,0

Da. Signa. To be applied on the affected skin areas.The pharmaceutist incorporated drymedical substance into the ointment bythe following way:

A. Triturated with a few vaseline oil dropsB. Triturated with a few ethanol dropsC. Triturated with a few water dropsD. Added to molten vaselineE. Triturated with a part of vaseline

19. For granule drying different types ofdryers are used. The dryer SP-30 relatesto the following type:

A. With fluidized bedB. SublimationC. InfraredD. With silica gel columnE. With a forced air circulation

20. Specify the herbal raw material withhigh concentration of carotinoids which isused for production of phytopreparations:

A. Sea-buckthorn fruitsB. Currant leafletsC. Caseweed grassD. Wild strawberry leavesE. Parsley roots

21. For the purpose of sales stimulati-on a pharmaceutical wholesale company


grants its customers a discount accordingto the social contract and on condition oftheir loyalty. Specify the type of discount:

A. BonusB. DealerC. SeasonalD. Discounts for quantity of purchasedgoodsE. -

22. One of the quality indicators for fini-shed ampoules is lack of residual stressin the glass. Which operation at thestage "Preparation of ampoules to be fi-lled"eliminates this imperfection?

A. Ampoule annealingB. Capillary openingC. Ampoule washingD. Ampoule dryingE. Ampoule sterilization

23. Companies producing injectabledosage forms apply different methods ofampoule sealing. Sealing against a jet ofinert gases (nitrogen, argon, carbon dioxi-de) is suitable for the following injectionsolutions:

A. Easily oxidableB. ViscousC. ThermostableD. Hydrolytically unstableE. Photosensitive

24. Quality control of tablets producedat a pharmaceutical enterprise involvesquantitative determination of such subsi-diary substances as talc and aerosil. Whatmethod is applied for such determination?

A. GravimetricB. TitrimetricC. PhotocolorimetricD. SpectrophotometricE. Chromatographic

25. Pharmaceutical plants produceenteric-coated tablets. According to therequirements of the State Pharmacopoeiaof Ukraine, the coating mustn’t disi-ntegrate in the acidic medium within thefollowing period:

A. 1 hourB. 2 hoursC. 4 hoursD. 3 hoursE. 5 hours

26. A patient with depression has beenadministered a drug from the group of tri-

cyclic antidepressants. Specify this drug:

A. AmitriptylineB. PhenazepamC. DroperidolD. AminalonumE. Caffeine

27. In the medical practice this compoundis used as a disinfectant. In case of intoxi-cation with this compound the patient’surine turns olive or olive-black. Specifythe compound:

A. PhenolB. Isoamyl alcoholC. IodoformD. Ethyl etherE. Ethyl lbenzoata

28. A patient with hypertension has beenadministered one of antihypertensivedrugs. Blood pressure dropped back tonormal, but the patient has developeda persistent dry cough. Which of thefollowing drugs has such a side effect?

A. Enalapril maleateB. PropranololC. ClonidineD. FurosemideE. Nifedipine

29. A patient suffering from ulcer diseasewas prescribed famotidine. What is themechanism of its action?

A. Block of �2-histamine receptorsB. Block of �1-histamine receptorsC. Block of muscarinic cholinoreceptorsD. Inhibition of adenosine triphosphataseactivityE. Block of cholinoreceptors ofsympathetic ganglions

30. According to the requirements ofthe State Pharmacopoeia of Ukraine, apharmacy analyst determines iron admi-xture in a preparation by means of citricand thioglycolic acids. What staining indi-cates presence of this admixture?

A. PinkB. GreenC. YellowD. BlueE. Black

31. Name the reason for the reducti-on of anticoagulant effect of syncumarwhen it is applied in combination withphenobarbital:


A. Phenobarbital activates microsomalliver enzymesB. Phenobarbital inhibits microsomal liverenzymesC. Development of syncumar allergyD. These drugs are antagonistsE. Mutual inactivation

32. Calamus rhizome is likely to beconfused with some other plant rhizomethat can be found as an admixture in theherbal raw material. Specify the most li-kely admixture:

A. Iris rhizomeB. Valerian rhizomeC. Elecampane rootsD. Althaea rootsE. Phlojodicarpus roots

33. Tannins can be used as an antidote foralkaloid poisoning. What herbal remedyshould be applied in case of such intoxi-cation:

A. Cinquefoil rootB. Calamus rhizomeC. Althaea rootD. Rhizome and roots of madderE. Elecampane root

34. Tannins have astringent effect and areused for treatment of colitis, enterocoli-tis, diarrhea. What herbal raw materialcontains a lot of tannins?

A. Fructus MyrtilliB. Fructus Sambucci nigriC. Fructus Ribes nigriD. Fructus Rhamni catharticaeE. Fructus Frangulae

35. Cardioglycosides of Adonis vernalisare used for heart failure treatment. Thisplant raw material should be stored:

A. According to the list BB. According to the list AC. Under normal conditionsD. Protected from CO2

E. In metal containers

36. A pharmacy manager is writing themonthly "Inventory report". What busi-ness transactions should be represented inthe expenditure item of the report?

A. Drug salesB. Plant raw material purchasesC. Payroll paymentD. Amortization charged to operationE. Extra-evaluation of laboratory-packaging works

37. During inventory of a pharmacythe surplus of inventory holdings wasrevealed. What actions concerning thesurplus should be taken by the inventorycomission?

A. Take on chargeB. Confiscation by superior organizationC. AbolishmentD. Immediate realizationE. Writing-off

38. A pharmacist made eye drops of pi-locarpine hydrochloride and adrenali-ne hydrochloride solution. A peculiari-ty of the incorporation of the adrenalinehydrochloride solution is that it is added:

A. After sterilization, asepticB. After dissolving of solidsC. To the half dose of solventD. In the first placeE. After isotoning

39. A patient has chronic pancreatitis wi-th apparent manifestations of pancreaticexocrine hypofunction. Which of thefollowing drugs would be the mostappropriate in this case?

A. РаncreatinumB. DrotaverineC. Dе-NоlD. ОmерrаzоlеE. Acidin pepsinum

40. Underground organs of medicinalplants that accumulate the most of acti-ve substances should be collected:

A. After the seeds have ripened and theoverground parts died offB. At the flowering stageC. During the green fruitingD. At the budding stageE. At the stem extension stage

41. In Ukraine the out-patients are suppli-ed with narcotic and psychotropic drugsonly by prescription. Medicoprophylacticinstitutions receive prescription blanks(Form 3) from the following source:

A. Pharmacy storehouseB. City’s health departmentC. Wholesale companiesD. TypographyE. Pharmaceutical corporation

42. A patient has been administeredpowders containing menthol. What is thebest way to achieve the required extent ofmenthol comminution?


A. To triturate it with alcohol or etherB. To triturate it with glycerine orchloroformC. To triturate it with purified waterD. To triturate it with other components ofthe formulationE. To triturate it thoroughly with sugar

43. Stability of suspensions can beenhanced by substances which increasethe viscosity of the dispersion medium.Specify the substance that exhibits suchproperties:

A. GlycerolB. Purified waterC. EthanolD. DimexidE. Ether

44. A doctor prescribed an olive oilemulsion whose composition includesanesthesin. In order that anesthesin canbe incorpotated into the emulsion itshould be dissolved:

A. In the oil before emulsifyingB. In the mature emulsionC. In the treated waterD. In the primary emulsionE. In the alcohol and add to the primaryemulsion

45. О-methylation is an important methodof organic substances biotransformationin the body, compounds that are subjectto such method contain:

A. Phenolic groupsB. AmidesC. Tthiol groupsD. Nitro groupsE. Carboxyl groups

46. Which antiseptic preparation hasbactericidal effect due to the formationof atomic oxygen?

A. Potassium permanganateB. ChloraminumC. FuracilinumD. AethoniumE. Silver nitrate

47. Styles of maize with stigmata contai-ning fatty acids, vitamins, essential oils,saponins and other substances are used as:

A. Diuretic and cholereticB. Sedative and anticonvulsantC. Cardiotonic and antiarrhythmicD. Expectorant and antibechicE. Bactericidal and astringent

48. One of the tablet coatings isenterosoluble capsule. They get solved in:

A. BowelsB. StomachC. Oral cavityD. RectumE. -

49. It is required to analyse some herbalraw material in form of shiny black drupesup to 6-8 mm in diameter; the bone islarge, very firm, spherical, light brown, wi-th a single seed; it has a sweet, slightlyastringent taste. This herbal raw materialshould be qualified as a fruit of:

A. Bird cherryB. BlueberryC. Black chokeberryD. BuckthornE. Hawthorn

50. Which of the following non-steroidanti-inflammatory agents has the leastharmful effect on the mucosa of thegastrointestinal tract?

A. NimesulideB. DiclofenacC. IndomethacinD. PiroxicamE. Acetylsalicylic acid

51. A pharmaceutist prepared eyedropswith boric acid. What sterilization methodwas applied?

A. Sterilization by saturation vaporpressureB. TyndallizationC. Sterilization by dry heatD. Sterilization by gasesE. By high-frequency current

52. A pharmaceutist refused preparati-on of nasal drops to a patient because ofincompatibility between collargol and di-medrol written in the prescription. Whatis the reason for incompatibility betweenthese ingredients?

A. CoagulationB. ImmiscibilityC. AdsorptionD. DissectionE. Eutectic formation


53. A pharmaceutist was preparing an oi-ntment with ricin oil and Vaseline but fai-led to get homogenous system. What isthe most likely cause of incompatibilitybetween these components?

A. Component immiscibilityB. Restricted solubilityC. Release of water of crystallizationD. CoagulationE. Adsorption

54. A doctor wrote a prescription for thetincture of digitalis with hydrochloric acid.What is the reason for their incompatibi-lity?

A. Hydrolysis (with no visible change)B. PrecipitationC. GassingD. Change in colourE. Change in odour

55. At the initial stage of establishing apharmaceutical enterprise the internal di-sciplinary regulations should be adopted.One of the primary matters is the durati-on of the lunch break for the employees.According to the Labour Code of Ukrai-ne, the break duration must be as follows:

A. Up to 2 hoursB. Up to 1 hourC. Not less than 3 hoursD. 2,5 hoursE. -

56. A 26-year-old patient was diagnosedwith community-acquired pneumoniaprovoked by mycoplasma. Choose theappropriate antimicrobial preparation forthe patient treatment:

A. RovamycineB. AmoxicillinC. GentamycinumD. ВеnzylpenicillinumE. Amoksiklav

57. A 60-year-old patient has essenti-al hypertension stage II, coronarydisease, bronchial asthma. Afterpharmacotherapy correction the patientexhibited a bronchospastic attack, intensi-fied dyspnea. What drug provoked thiscomplication?

A. PropranololB. NifedipinеC. ЕuphyllinumD. МucaltinumE. Salbutamolum

58. After an emotional stress a 60-year-oldpatient presented with chest pain irradi-ating to the left arm. Specify a drug thatrelieves pain in this case:

A. NitroglycerineB. NifedipineC. DiltiazemD. PropranololE. Metoprolol

59. A 70-year-old patient consulted adoctor about elevated arterial pressure.He has a history of benign hyperplasiaof prostate. What drug should be admini-stered in this case?

A. DoxazosinB. ЕnаlаprilC. PropranololD. DiltiazemE. Losartan

60. A pharmaceutist revealed incompati-bility in a prescription for powders withascorbic acid and hexamethylenetetrami-ne. What process takes place when thesecomponents are combined?

A. Mixture dampeningB. Eutectic formationC. ImmiscibilityD. Substances adsorptionE. Crystallization water exudation

61. A pharmaceutist made a medicinalpreparation according to the followingformulation:Rp.: Chloroformii

Olei HelianthiMethylii salicylatis ana 10,0M.D.S. For infriction.

Specify the kind of disperse system:

A. Liniment - solutionB. Liniment - combinedC. Liniment - emulsionD. Liniment suspensionE. Liniment - extractional

62. In order to get registered in stateauthorities pharmacies as legal personsmust possess authorized capital stock.What amount is identified as the authori-zed capital stock?

A. The amount recorded in constituentdocumentsB. The amount of noncurrent assetsC. The amount of fund formation sourcesD. Total assetsE. The amount of debts of an enterprise


63. According to the current legislation,pharmaceutists get the sickness benefit incase of temporary disability. Specify thesource of payment for the first 5 days ofbeing on the sick leave:

A. Pharmacy expendituresB. Pharmacy revenuesC. Pension fundD. Environment stimulation fundE. Reserve fund

64. Which of the listed antibacterial drugsshould NOT be administered to a pati-ent with diabetes mellitus type II beingtreated with glibenclamid?

A. Co-trimoxazolumB. MidecamycinC. GentamycinumD. BenzylpenicillinumE. Doxycycline

65. What drug may cause constipation in apatient undergoing combined therapy forarterial hypertension?

A. VerapamilB. FurosemideC. TrimetazidineD. PananginE. Acetylsalicilic acid in small dosages

66. A pharmacy plans to purchase andretail goods of different stock record units.Which group of goods does VAT reducti-on apply to?

A. MedicamentsB. Baby foodC. OpticsD. Curative cosmeticsE. Perfumes

67. Preliminary tests involve using variouskinds of indicator paper. Blackening ofthe indicator paper treated with plumbumacetate indicates that the biological objectcontains:

A. Hydrogen sulphideB. Hydrogen chlorideC. Ammonium hydroxideD. Sulphuric acidE. Sodium hydroxide

68. An analytical chemist makes a testfor the presence of sodium thiosulphate.Select a reagent which allows to detect thethiosulphate ion:

A. Hydrochloric acidB. Sodium bromideC. Potassium iodideD. Sodium hydroxideE. Magnesium sulfate

69. An analytical chemist determines theadmixture of sulphates in the boric acid.What is the main reagent that he has toadd:

A. Barium chlorideB. Sodium sulphideC. Potassium ferrocyanideD. Silver nitrateE. Ammonium oxalate

70. In order to arrest stenocardia attacks apatient takes nitroglycerin capsules. Whatis the rational way of the drug introducti-on?

A. SublingualB. PeroralC. RectalD. InhalationE. Hypodermic

71. Recommend a patient with acutebronchitis a mucolytic drug that ease diffi-culty in expectoration:

A. AcetylcysteineB. GlaucineC. LoratadineD. Diclofenac sodiumE. Drotaverine hydrochloride

72. A patient with atherosclerosis hasbeen administered an anti-atheroscleroticagent. Specify this drug:

A. PhenofibrateB. Ascorbic acidC. PyracetamD. DexamethasoneE. Phenylbutazone

73. A pharmacy received a batch of medi-cines from a pharmacy depot. Specify thedrug subject to the controlled substanceinventory in pharmacies:

A. DicaineB. ParacetamolC. AnalginD. NovocaineE. Acetylsalicylic acid

74. A pharmaceutical company conductedan age-specific segment analysis of theregional antihistamine market. It revealedthe lack of antihistamines for children.The company will consider this segment


as:

A. A market nicheB. An unattractive segmentC. A market shareD. A segment requiring further researchE. A market door

75. An obtained mineralisate containssulphates of lead, barium and stronti-um in form of white precipitation. Whatprocedure will allow to separate the leadsulphate?

A. Dissolution in ammonium acetateB. Dissolution in concentrated sulphuricacidC. Conversion into carbonateD. Conversion into diethyldithiocarbamateE. Conversion into arsine

76. A pharmacy received the followi-ng prescription: 0,0002 g of scopolaminehydrobromide per 1 powder. How muchof 1:100 trituration is required for thepreparation of 10 powders?

A. 0,2B. 0,04C. 4,0D. 0,4E. 2,0

77. A pharmacy received a prescription for3% alcohol solution of boric acid. Whatconcentration of ethyl alcohol is requiredfor preparing the drug form?

A. 70%B. 60%C. 40%D. 90%E. 96%

78. A licensed state-owned pharmacyobtains and retails narcotic drugs. Whichstate authority develops and revises thelist of the drugs allowed in Ukraine?

A. State servise on Narcotic Drugs Controlof UkraineB. State Inspectorate for Quality Controlof DrugsC. State Pharmacological CentreD. Public Joint Stock Company "Medi-caments of Ukraine"E. -

79. A pharmacy is engaged in retail salesof drugs. What group of drugs does atropi-ne sulphate relate to?

A. ToxicB. DrasticC. Over-the-counterD. NarcoticE. Psychotropic

80. An employee of a pharmaceuticalcompany has been commissioned wi-th marketing research on the regionalmarket of antiarrhythmic drugs. Whatstage of research would he prefer in thefirst place?

A. Collection and analysis of secondaryinformationB. Collection of primary informationC. Analysis of primary informationD. Preparation of reportE. Submission of report

81. A pharmaceutical company "Pfizer"isfocused on offering the best quality goodsat a high price which should cover thecosts of research and development as wellas production of high quality products.Despite the high price, the product is sti-ll in demand. What are the goals of thecompany’s price policy?

A. Winning the market leadership inrespect of product qualityB. Ensuring the company’s survivalC. Maintaining status quoD. Increasing the market shareE. Increasing the company’s assortment

82. A pharmaceutical company"Pharmasvet"has patented and producesnow a new hypoglycemic preparation. Thecompany markets this product directlythrough the own sales departments, affili-ated sales companies, pharmacy network.Marketing policy of this pharmaceuti-cal company can be characterized by thechannel of the following level:

A. Zero levelB. One-levelC. Two-levelD. Three-levelE. Four-level

83. A patient with cholelithiasis wasprescribed the following drug for thepurpose of cholesterol gallstone dissoluti-on:

A. Ursodeoxycholic acidB. Gamma-amino-butyric acidC. Acetylsalicylic acidD. Citric acidE. Mefenamic acid


84. Which of the listed methods of filli-ng ampoules with injectable solutions canprotect the capillaries from contaminationwith thick and viscous solutions?

A. Syringe methodB. Vacuum methodC. Turbo-vacuum methodD. Steam condensing methodE. Solution squeezing method

85. Production of injection solutionsinvolves an operation of solution filtrati-on. What filters are used for sterile filtrati-on?

A. Filter candlesB. Nutsch filtersC. Filter developed by the KharkivChemo-pharmaceutic Research InstituteD. Pressure filtersE. Mushroom filter

86. A 68-year-old female patient has beencontinuously taking furosemide for heartfailure treatment. What drug should beused to prevent hypokalemia in patientstaking furosemide?

A. PananginB. Atp-longC. MildronatumD. TrimetazidineE. Sustac forte

87. Eye drops are prepared with an oi-ntment base which is an alloy of vaseli-ne and lanolin. Specify the method of itssterilization:

A. Dry heatB. Ethylene oxideC. Flowing steamD. PasteurizationE. Tyndallization

88. Quantitative determination of si-lver nitrate is done by method of thi-ocyanatometry. What indicator is used inthis case?

A. Iron (III) ammonium sulphateB. PhenolphtaleinC. Potassium chromateD. Methylene blueE. Sodium eosinate

89. An analytical chemist was identifyingxeroform in reaction with sodium sulphi-de. As a result of reaction a black soliddropped out. What ion was detected?

A. BismuthB. LeadC. ZincD. CopperE. Silver

90. During the chemico-toxicologicalstudy of the dialysate of an aqueousextract, the ammonia test IS NOT carriedout if the dialysate includes the followingsubstance:

A. Hydrogen sulphideB. Sulphurous acidC. Sulphuric acidD. Nitric acidE. Nitrous acid

91. A forensic chemical laboratory recei-ved an object for analysis. The analysisinvolves quantitative determination ofmercury by means of a reaction with di-thizone. What physical-chemical methodis used within this analysis?

A. Extraction photocolorimetryB. Gas-liquid chromatographyC. UV spectrophotometryD. IR spectrophotometryE. Thin layer chromatography

92. A woman in the III trimester ofpregnancy has an acute respiratory vi-ral disease accompanied with bodytemperature rise up to 39oC. Which of thedrugs should be recommended?

A. ParacetamolB. CelecoxibC. IndomethacinD. Acetylsalicylic acidE. Diclofenac sodium

93. Suspensions as heterogenous systemscan be characterized by kinetic and sedi-mentary instability. What substance isused for increasing suspension stabilitywith hydrophobic substances?

A. GelatoseB. Sodium chlorideC. Boric acidD. Sodium sulphateE. Glucose

94. A patient presents with morphi-ne intoxication. Which drug should beinjected as an antidote?


A. NaloxoneB. Lobeline hydrochlorideC. BemegrideD. Atropine sulphateE. Unithiol

95. Most alkaloids are isolated from thebiological material by polar solvents. Whi-ch of the listed alkaloids is isolated by theway of distillation with water vapour?

A. ConiineB. StrychnineC. CocaineD. AtropineE. Quinine

96. Comparative analysis of theperformance of two pharmacies showedthat the trade stock in terms of days was 20and 30 days respectively. Which of theseindicators is NOT USED for calculatingthe trade stock?

A. Wage fundB. The rate of trade mark-upC. Sales volumeD. TurnoverE. The left-over goods in terms ofsettlement prices

97. A pharmacy received drugs that areincluded in the National List of EssentialMedicines. When supplying these drugs tothe public hospitals, pharmacies are enti-tled to mark-up the drug charges at therate of:

A. 10%B. 50%C. 40%D. 30%E. 20%

98. Sales of medical cosmetics retailed inpharmacies are taxable at the VAT rate of20%. Who is charged with it?

A. End consumerB. Product manufacturerC. Wholesale intermediator company firmD. PharmacyE. Customs service

99. A patient who has been suffering fromgastric diseases for a long time is foundto have hyperchromic anemia. Which ofthe following drugs is applied for thispathology treatment?

A. СyanocobalamineB. Ascorbic acidC. UnitiolD. Ferrum LekE. Охуferriscorbone

100. Essential oil of rose is used as an anti-inflammatory and antispasmodic agent.It is localized in the following excretoryorgans:

A. Glandular spotsB. Essential oil glandulesC. Essential oil conceptaclesD. Secretory cellsE. Glandular hairs

101. A chemist of an analytic laboratoryhas to prepare turbidity standards accordi-ng to the requirements of Pharmacopoeia.What substances are to be used as thereference?

A. Hexamethylenetetramine and hydrazi-ne sulphateB. Calcium sulphate and glycerinC. Sodium chloride and calcium nitrateD. Potassium chloride and barium sulphateE. Furacilinum and calcium chloride

102. A pharmaceutist plans voluntarytermination of the open-endedemployment contract for the reason of herhusband’s transfer to another area. Speci-fy the form and term of notice that shouldbe given to the pharmacy director:

A. Two-week notice in written formB. One-week notice in written formC. One-month notice in written formD. Five-day notice in written formE. Two-day notice in written form

103. A pharmacy makes wholesalepurchases of health and hygiene products.An agent works under the contract withthe manufacturer and makes deals at themanufacturer’s cost. The agent may beentitled to exclusive distribution in someregions. What kind of agent is it?

A. Wholesale agentB. ConsigneeC. Commission agentD. BrokerE. Dealer

104. How much water should be takenin order to prepare 200 ml of aqueousextract of motherwort (water absorptioncoefficient = 2 ml/g)?


A. 240 mlB. 220 mlC. 200 mlD. 160 mlE. 210 ml

105. During the identification of adrug an analytical chemist of the StateInspectorate for Quality Control performsa lignin test. Specify this drug:

A. StreptotcidB. Ascorbic acidC. Cortisone acetateD. MethionineE. Analgin

106. A pharmacist-analyst carriesout quantitative analysis of procainehydrochloride. Which of the followingsolutions is to be used?

A. Sodium nitriteB. Sodium thiosulfateC. Sodium edetateD. Potassium bromateE. Argentum nitricum

107. The main active components ofhawthorn berries are flavonoids. What istheir pharmacological effect?

A. Hypotensive and sedativeB. Laxative and sedativeC. Tonic and antispasmodicD. Diuretic and stypticE. Antispasmodic and anti-inflammatory

108. Name a "metal poison"which isisolated from the biological material bythe method of destruction:

A. MercuryB. StibiumC. CadmiumD. SilverE. Arsenic

109. Toxic substances can be isolated fromthe objects of biological origin by di-fferent methods. In case of intoxicationwith pesticides - derivatives of phosphoricacids - the following method is applied:

A. Infusion with organic solventsB. Distillation with water steam from thealkaline mediumC. Infusion with alkalized waterD. Infusion with water acidified withchloric acidE. Dialysis from alkalized solutions

110. A pharmacy analyst carries out puri-ty test of the drug substance "Sodium thi-

osulfate". Violet colour, that comes fromreaction with sodium nitroprusside, indi-cates the presence of the following admi-xture:

A. Specific sulfides admixtureB. Sulphates admixtureC. Sulfur admixtureD. Sodium chloride admixtureE. Iodides admixture

111. An analytic laboratory received"Aether anaestheticus"for analysis. Whi-ch reagent should be used for detection ofacetone and aldehyde admixtures accordi-ng to the State Pharmacopoeia of Ukrai-ne?

A. Alkaline solution of potassium tetrai-odomercurateB. Ammonium solution of argentum ni-trateC. Aqueous solution of potassium iodideD. Sodium hydrosulphiteE. Hydroxylamine solution

112. Activity of an organization dependson various factors. What factors refer tothe internal environment of the organi-zation?

A. Abilities, skills and talent of staffB. Economy statusC. InfrastructureD. Public authoritiesE. Consumers

113. Financial accountability of pharmaci-es consists of separate account forms.Which form presents accounts payable forthe goods purchased?

A. Balance sheet, form 1B. Financial performance report, form 2C. Financial performance report, form 2mD. Net worth statement, form 3E. Balance assets, form 1

114. In Ukraine natural persons as smallbusiness entities are allowed to use thesimplified tax system. What limit on thenumber of employees is established forsuch enterprises?

A. No more than 10 personsB. No more than 20 personsC. No more than 30 personsD. No more than 40 personsE. No more than 50 persons

115. For the natural persons being smallbusiness subjects the simplified tax systemis effective. But there is a limit of annual


proceeds upon sale. What is the boundaryamount of proceeds?

A. Up to 500 thousand UAHB. Up to 750 thousand UAHC. Up to 100 thousand UAHD. Up to 1 million UAHE. Up to 5 million UAH

116. Simplified tax system impliesreplacement of several taxes by a si-ngle one. What limit on the number ofemployees is established for the legalpersons to implement the simplified taxsystem?

A. 50 personsB. 10 personsC. 25 personsD. 100 personsE. 75 persons

117. Fatty oil containing saturated fattyacids is used for atherosclerosis preventi-on. Specify the medicinal plant that isused for oil production:

A. Flax seedsB. Fennelflower seedsC. Dill seedsD. Black chokeberry fruitsE. Hawthorn fruits

118. A tablet shop produces triturati-on tablets. What quality indicators ARENOT relevant for these tablets?

A. Abrasion, resistance to crushingB. Disintegration and dissolutionC. Homogeneity of dosageD. Homogeneity of contentE. Microbiological purity

119. A phytochemical production unitproduces biogenic stimulators out of di-fferent raw materials. Specify the biogenicstimulators of organo-mineral origin:

A. Peloidinum, Humisolum, Torfotum,Fibs pro injectionibusB. Extractum Aloes fluidum, LinimentumAloes, Succus Aloes, BiosedumC. Vitreous body, Placenta injection,Рlasmolum, SolcoserylD. Extractum Aloes fluidum, LinimentumAloes, РlasmolumE. Peloidinum, Humisolum, Torfotum,Рlasmolum, Solcoseryl

120. A pharmaceutical enterpriseproduces water solutions. The solutionof the following substance is producedby method of chemical interaction and

electrochemically:

A. Aluminum hydroxide acetateB. Plumbum hydroxide acetateC. Calcium gluconateD. Polyvinyl alcoholE. Potassium arsenite

121. In course of preparation of supposi-tories by the pumping method thesuppository mass became viscous andfluid after the incorporation of chloralhydrate into the cocoa butter. Whatsubstance should be added to the supposi-tory mass in order to restore its densityand plasticity?

A. WaxB. GlycerineC. Purified waterD. DimexidE. Starch

122. Powders make up an importantgroup among the extemporal medici-nal preparations. Which of the followi-ng components can be incorporated intoa powder without being preliminarilyground?

A. Basic Bismuth nitrateB. Ascorbic acidC. CamphorD. XeroformE. Calcium gluconate

123. Qualitative reaction for phenol isthe reaction with bromine water. Whatcompound is produced as a result of theinteraction of phenol with bromine waterand drops out as a white solid?

A. 2,4,6-tribromophenolB. 2-bromophenolC. 3-bromophenolD. 4-bromophenolE. 2,4-dibromophenol

124. Upper airways diseases can betreated by means of herbal raw materi-als containing mucilages. The plant sourceof this compound class is:

A. Radix AlthaeaeB. Radix InulaeC. Radix IpecacuanhaeD. Radix RhodiolaeE. Radix Belladonnae

125. The basic structure of steroidhormones is hydrocarbon skeleton -cyclopentane perhydrophenanthrene.What natural compound is used for


testosterone propionate production?

A. CholesterolB. IndoleC. NaphthaleneD. PhenanthreneE. Anthracene

126. According to the requirements ofthe State Pharmacopoeia of Ukraine,a pharmacy analyst should determineprocaine hydrochloride by nitritometricmethod. What indicator is to be used forthis purpose?

A. Neutral redB. Methyl redC. Crystal violetD. Xylenol orangeE. Acid chrome blue

127. According to the requirements ofthe State Pharmacopoeia of Ukraine,a pharmacy analyst should determinefluorouracil by method of nonaqueoustitration. What titrated solution is to beused?

A. Tetrabutyl ammonium hydroxideB. Sodium nitriteC. Potassium bromateD. Ammonium thiocyanateE. Sodium edetate

128. An analytical chemist analyses thesubstance of ethylmorphine hydrochlori-de. The substance purity is tested bymethod of semi-microanalysis. Whatreagent is used to determine the wateradmixture?

A. IodosulphurousB. BiureticC. Methoxyphenyl acetic acidD. Molibdeno-vanadiumE. Hypophosphite

129. An analytical laboratory carri-es out an analysis of ferrum sulphateheptohydrate according to the requi-rements of the State Pharmacopoeia ofUkraine. The test portion of the substanceshould be titrated with the followingsolution:

A. Ammonium cerium sulfateB. Argentum nitrateC. Ammonium thiocyanateD. Sodium edetateE. Potassium bromate

130. A patient consults a pharmaceuti-st about taking acetylsalicylic acid as an

antiaggregant. What is the daily dose thatshould be recommended for continuoususe?

A. 0,1-0,3 gB. 0,5-1,0 gC. 1,0-2,0 gD. 2,0-3,0E. Over 4,0 g

131. The main active components of sennaleaves and fruits are sennosides A, B, C,D. They relate to the following class of bi-ologically active substances:

A. Anthracene derivativesB. Phenolic acidsC. FlavonoidsD. IridoidsE. Thioglycosides

132. A laboratory received some herbalraw material for analysis. It is a composi-tion of ovoid-pointed leaves up to 25cm long and 20 cm wide; the leaf baseis cuneate, the leaf edge is emarginate.The cutting is long and cylindric. The leafvenation is pinnatisect; the midrib and thefirst-order veins project significantly onthe inferior surface of the leaf. The superi-or leaf surface is dark green, the inferi-or surface is light green. The plant has aweak narcotic smell. The taste cannot bedetermined. The plant is poisonous! Thedescribed herbal raw material relates tothe following plant:

A. Datura stramoniumB. Passiflora incarnataC. Chelidonium majusD. Vinca minorE. -

133. It is necessary to prescribe non-steroid anti-inflammatory drug for patientwith rheumatoid arthritis and concomi-tant duodenal ulcer. Which drug is thedrug of choice in this case?

A. CelecoxibB. Acetylsalicylic acidC. ParacetamolD. AnalginE. Diclofenac sodium

134. A pharmaceutist is preparingpowders according to the followingformulation:


Rp.: Scopolamini hydrobromidi 0,0003Ephedrini hydrochlorodi 0,05Sachari 0,15M.f. pulvisD.t.d. № 10S. 1 powder thrice a day.

Calculate the mass of 1 powder providingthat the trituration (1:100) is used:

A. 0,20B. 0,15C. 0,23D. 0,17E. 0,203

135. A pharmaceutist prepares several di-fferent solutions with antibiotics underaseptic conditions. He can sterilize thesolution of the following substance:

A. ChloramphenicolB. Benzylpenicillin-sodiumC. Neomycin sulphateD. Benzylpenicillin-potassiumE. Polymyxin sulphate

136. A pharmaceutist has revealed anincompatibility in the prescription. Whatdrug substances form an eutectic mixture?

A. Chloral hydrate + camphorB. Antipyrine + analginC. Calcium chloride + sodium chlorideD. Ephedrine hydrochloride + glucoseE. Sodium hydrocarbonate +hexamethylenetetramine

137. The risk can arise from some formsof activity connected with producti-on of goods and services, their selling,commodity-money and financial operati-ons, commerce, implementation of soci-oeconomic and scientific-and-technicalprojects. This is the definition for thefollowing concept:

A. Business riskB. Loss of propertyC. Labour lossD. Loss of timeE. Financial loss

138. While studying the reaction of an"acid"chloroform extraction in acidicmedium with sodium nitrite, a forensictoxicologist got a compound stainedemerald green. Which of the substancesis capable of forming the mentioned ni-trose compound?

A. AntipyrineB. AnalginC. AmidopyrineD. NoxironE. Salicylic acid

139. A patient got poisoned with nitri-tes. Nitrite detection by means of azo dyereaction involves using such acid:

A. SulphanilicB. SulphuricC. PhosphoricD. HydrochloricE. Salicylic

140. Preparations made out ofeleutherococcus roots and rhizomes areadministered as a tonic and adaptogenicdrug. If these preparations cannot befound in a pharmacy, they can be substi-tuted by the analogous preparations madeof the following raw material:

A. Ginseng rootsB. Elecampane rootsC. Rhizomes and roots of valerianD. Polemonium rootsE. Acorus calamus roots

141. A patient with bronchial asthma hasbeen administered a drug from the groupof beta-adrenergic agonists. Specify thisdrug:

A. SalbutamolB. DiazepamC. Doxycycline hydrochlorideD. NitroglycerineE. Digoxin

142. An analytical chemist determinesthe quantitative content of caffeine bymethod of acidometry in nonaqueousmedia in compliance with the StatePharmacopoeia of Ukraine. What soluti-on is used as a titrant?

A. Perchloric acidB. Sodium edetateC. Potassium bromateD. Sodium hydroxideE. Sodium nitrite

143. A pharmacy analyst identifies sodiumhydrocarbonate. What indicator can confi-rm the presence of alkalescent mediumreaction in the sodium hydrocarbonatesolution?


A. PhenolphtaleinB. StarchC. Tropeolin 00D. FerroinE. Naphtholbenzein

144. Substance of calcium pangamate isto be studied in n analytical laboratory.Calcium cation forms a white precipitatewith the following reagent:

A. Ammonium oxalateB. Sodium chlorideC. Potassium permanganateD. Potassium bromideE. Sodium cobaltinitrite

145. A chemist of an analytical laboratorystudies procaine hydrochloride accordi-ng to the requirements of the StatePharmacopoeia of Ukraine. Whatmethod is recommended by the StatePharmacopoeia of Ukraine for the quanti-tative analysis of this preparation?

A. NitritometryB. BromatometryC. AcidimetryD. AlkalimetryE. Chelatometry

146. A patient has been administered aspasmolytic from the group of muscari-nic receptor antagonists as a part of thecomplex treatment for renal colic. Specifythis drug:

A. AtropineB. NeostigmineC. GalantamineD. DithylinumE. Benzohexonium

147. A common method for quantitativedetermination of drugs from the group ofalkali metal halogenides is:

A. ArgentometryB. PermanganatometryC. ChelatometryD. AlkalimetryE. Nitritometry

148. A patient has been taking isosorbi-de for stenocardia prevention for quitea long time. Now he notes a significantdecrease in the effect of the drug. What isthis phenomenon called?

A. ToleranceB. CumulationC. Physical dependenceD. AllergyE. Potentiation

149. Pharmacy activities are commonlyoperated by different types of managers.The function of direct control over drugpreparation by a pharmaceutist refers tothe following type of management:

A. TechnicalB. InstitutionalC. ManagerialD. AdministrativeE. Bureaucratic

150. A pharmaceutist has applied fora job of a stockkeeper at a wholesalepharmaceutical enterprise. What trialperiod doesn’t require agreement with thetrade-union committee?

A. Up to three monthesB. Up to one monthC. Up to two monthesD. Up to four monthesE. Up to six monthes

151. Marketing manager at a pharmaceuti-cal factory is planning its communicationpolicy. Which component of the marketi-ng communication systems has the highestvalue for one contact?

A. Personal saleB. "Public relations"C. TV advertisingD. Periodical advertisingE. Sales promotion

152. During the treatment of chronic heartfailure with digoxin in a patient havingbradycardia, nausea, vomiting, blurred vi-sion. Which drug is the antidote in thiscase?

A. UnithiolB. Tetacinum calciumC. DipiroximumD. Amyl nitriteE. Atropine sulphate

153. A biennial or perennial plant fromthe Apiaceae family has a blue-grey stembranching in its lower part. Its leaves arealso blue-grey, finely dissected, with theultimate filiform segments. The flowersare yellow, in compound umbels. Its fruitis used for production of "dill water".What plant is it?


A. Foeniculum vulgareB. Carum carviC. Petroselium crispumD. Coriandrum sativumE. Conium maculatum

154. Incoming control is conducted in thecourse of wholesale and retail trade, suchcontrol is carried out during receipt ofgoods by visual inspection or analysis ofdrug. Incoming control is carried out byauthorized person, which is assigned by:

A. Managers orderB. State inspection of drugs quality controlC. Head of regional structureD. Proprietor of an enterpriseE. The order of head of territorial inspecti-on

155. When a pharmacy records goods asreceived, it normally specifies the amountof the markup intended for expenditurecoverage and profit gaining. Give the defi-nition for the markup:

A. The difference between the sale priceand purchase price of goodsB. The difference between the sales priceand markupC. The difference between the sales priceand the customs priceD. The amount of goods soldE. Rummage (goods remains) at the endof the month

156. Before the raw plant material is takenover from the supplier, it must be checkedfor compliance. Which document is theground for recording raw plant materialas received in the pharmacy in case of itsapproval?

A. Acceptance certificateB. Consignation noteC. Write-off certificateD. InvoiceE. -

157. The relationships between thedemand, supply and price level is studi-ed within the following field of complexmarket research:

A. Studies of economic environmentB. Studies of market and product requi-rementsC. Analysis of market segmentationD. Studies of market structure of compani-esE. Analysis of sociopsychological featuresof buyers

158. According to the Labour Code,compulsory deductions from the salari-es of pharmacy employees include:

A. Pension contributionsB. AlimonyC. Excess paymentsD. Amounts to be withheld under writs ofexecutionE. Trade union contributions

159. According to the basic regulationsfor supply of medical products, pharmaci-es should be supplied with medicamentshaving a remaining shelf life of no lessthan . . .%, and bacterial preparations ofno less than . . .%:

A. 60%, 40%B. 80%, 60%C. 50%, 40%D. 40%, 20%E. 60%, 30%

160. A patient with chronic bronchitiswants to buy glaucine hydrochloride at apharmacy. What typical side effect of thedrug should the patient be warned agai-nst?

A. Drop of arterial pressureB. Excitation of the central nervous systemC. Irregular heartbeatD. Rise of intraocular pressureE. Allergic skin rash

161. A 30-year-old patient with a sleep di-sorder and psychoemotional disbalancehas been administered diazepam. What isthe mechanism of its psychosedative acti-on?

A. Activation of GABAergic systemB. Inhibition of the limbic systemC. Inhibition of the reticular formationD. Reduction of noradrenaline amount inthe CNSE. Inhibition of opioid receptors

162. Benzylpenicillin sodium is not usedper os, because this drug:

A. Destroys gastric HClB. Poorly absorbed in the intestineC. Irritates gastric mucosaD. Reduces formation of gastric HClE. Is destroyed by penicillinase

163. Select the reductant required for thedetermination of arsenic impurity in drugs(method 2):


A. Sodium hypophosphiteB. Hydrochloric acid solutionC. Sodium sulfite solutionD. Sodium hydroxide solutionE. Potassium iodide solution

164. A pharmacy received a prescriptionfor powders with a too high single doseof phenobarbital not justified by properdocumentation. What actions should apharmaceutist take?

A. Put the stamp "invalid"and return theprescription to the patientB. Supply 1/3 of the maximum single doseC. Supply the maximum single dose, multi-plied by the number of powdersD. Supply the highest single doseE. Supply 1/3 of the maximum single dose,multiplied by the number of powders

165. When heroin comes into an anorganism, it metabolizes chiefly to:

A. Morphine and 6-monoacetylmorphineB. CodeineC. MorphineD. 6-acetylmorphineE. 3-acetylmorphine and morphine

166. A pharmacy received a prescriptionfor a topical powder including a substancethat is hard to disperse. Which of the li-sted fluids may be used for dispersing thesubstance?

A. Diethyl etherB. Purified waterC. Water for injectionsD. DimexidE. Isopropyl alcohol

167. A female has prolonged labour. Selecta drug that stimulates labour activity dueto its physiological effect from the listedbelow:

A. OxytocinB. NeostigmineC. PachycarpineD. ProgesteroneE. Estrone

168. A pharmaceutist has to preparesuppositories with a glycerine gelatin baseby the molding method. What is the ratioof gelatin, water and glycerine requiredfor the base?

A. 1:2:5B. 2:2:4C. 1:3:4D. 2:1:5E. 3:2:3

169. While filling hard gelatin capsulessuch glidants as 0,1% - 0,3% aerosil ormagnesium stearate along with 0,5% - 1%talc are often added to the filling agent inorder to improve the following properties:

A. FlowabilityB. HomogeneityC. Regulation of moisture contentD. Homogeneity of mixingE. Ability to contact molding

170. Prescriptions for drugs being subjectto the stocktaking and supplied onfavourable terms or free of charge exceptfor narcotic (psychotropic) drugs andtramadol are written out:

A. In 2 copies of form F-1B. On the pink formC. On the form F-3D. On the form F-1E. On the forms F-3 and F-1

171. What management style is characteri-zed by manager’s particular compliance,when manager initiates goals formationby his subordinate and is ready to acceptit without reservations?

A. Laissez-faire management styleB. Democratic management styleC. Bureaucratic styleD. Collective styleE. Combined style

172. Activity of pharmaceutical insti-tutions is subject to licensing. What isthe duration of licencse for drugs andhealthcare products sale?

A. Five yearsB. One yearC. Two yearsD. Four yearsE. Three years

173. In case of loss of license apharmaceutist should address an appli-cation for a duplicate to a licensingauthority. The licensing authority is obli-ged to issue the duplicate to the applicantno later than:


A. Three working days from the date ofapplication receiptB. One month from the date of applicationreceiptC. Two monthes from the date of applicati-on receiptD. Three monthes from the date of appli-cation receiptE. The duplicate isn’t issued

174. Which component of the marketingcommunication system focuses on creati-ng a positive image of a company?

A. Public relationsB. AdvertisingC. Personal salesD. Retail logisticsE. Merchandising

175. Select a loop diuretic of strong,emergency and short-term action from thelisted below:

A. FurosemideB. ClopamideC. AcetazolamideD. SpironolactoneE. Triamterene

176. A laboratory received some herbalraw material for analysis. The plant hadflowerheads up to 4 cm in diameter,the marginal flowers were agamic, blue,funnel-shaped; the inner flowers were bi-sexual, purple, tubular. What plant hasthese features?

A. Centaurea cyanusB. Solidago virgaureaC. Polygonum persicariaD. Scutellaria baicalensisE. Viola tricolor

177. Spesify the type of the following lini-ment: Ol. Helianthi 7,4

Sol. Ammonii caustici 25 mlAc. Oleinici 0,1M.f. linimentumD.S. To be rubbed in.

A. Liniment, emulsion o/wB. Combined linimentC. Liniment-solutionD. Liniment-suspensionE. Liniment, emulsion w/o

178. A patient who has been undergoingcombined drug therapy for peptic ulcerpresents with black feces. Specify a drugthat might have caused such a change:

A. Bismuth subcitrateB. OmeprazoleC. ActoveginD. MetronidazoleE. Ranitidine

179. A man with a long history ofchronic hepatitis has been diagnosed withpneumonia. Which of the following anti-bacterial drugs can be applied in this cli-nical situation?

A. AmoxicillinB. TetracyclineC. BiseptolD. RifampicinE. Vancomycin

180. A 57-year-old female patient was di-agnosed with rheumatoid arthritis; shehas also a history of stomach ulcer. Whatdrug from the group of nonsteroid anti-inflammatory drugs may be recommendedthis patient?

A. CelecoxibB. DiclofenacC. AspirinD. IndometacinE. Mefenamic acid

181. An internship doctor prescribed hispatient nifuroxazid from the group of ni-trofurans for the treatment of urinarytracts infection. The doctor made a mi-stake because:

A. It cannot be absorbed from the digesti-ve tractB. It is excreted with urine in the inactivestateC. It has nephrotoxic effectD. It has bacteriostatic effectE. It is excreted from the organism veryslowly

182. Which of the following is the drugof choice for bronchial asthma attacksprevention?

A. Cromolyn sodiumB. SalbutamolC. DrotaverineD. Diphenhydramine hydrochlorideE. Ambroxol

183. A pharmaceutist needs to sterilize250 ml of glucose solution for injections.How many minutes should the soluti-on undergo sterilization in the autoclaveunder the temperature of 120oC?


A. 12B. 8C. 15D. 25E. 30

184. Grinding equipment is classified bythe way of grinding. What kind of machi-nes does a roller crusher relate to?

A. CrushingB. CuttingC. AbrasiveD. ImpactE. Impact-centrifugal

185. Antacid gastritis can be treated wi-th plantain juice. What is the way of itsextraction?

A. High-pressure compressionB. Extraction with condensed gasesC. Maceration with aqueous ethanolsolutionD. Dissolution of concentratesE. Repercolation

186. Oxidation of some toxins within thebody results in generation of compoundsthat increase their toxicity. Thus, due tothe oxidation of heptachlor in the bodythe folowing compound is formed:

A. Heptachlor epoxideB. Carbon monoxideC. Carbon dioxideD. Heptachlor oxideE. Hexachlorocyclohexane

187. A pharmacy has sulfonamide biseptolon sale. What chemical compounds arethe main components of this drug?

A. Sulfamethoxazole, trimethoprimB. Sulfazin, salazodimethoxinumC. Sulgin, norsulfazolD. Phthalazolum, sulfadimezinE. Urosulfan, sulfapiridazin

188. In course of isoniazid identification apharmacy analyst boiled thoroughly thesubstance with 2,4-dinitrochlorobenzene.The substance turned yellow, after addi-ng alkaline solution it turned first violetand then brownish-red. As a result of thisreaction the following aldehyde derivativeis produced:

A. GlutakonB. GluconicC. GlutamicD. GlyoxylicE. Hexanic

189. A routine inventory revealed a cashshortage. Who must reimburse the sum ofthe identified shortage?

A. CashierB. Pharmacy directorC. Deputy director of pharmacyD. Department headE. Deputy head of Department

190. A pharmaceutical factory producesherbal juice out of fresh raw material.What operation should be performed atthe stage of juice purification?

A. Heating followed by quick coolingB. SedimentationC. AdsorptionD. FiltrationE. Crystallization

191. A patient suffering from stomachulcer was prescribed an antiulcer drug thatalso reduces secretion of hydrochloric acidand inhibits Chelicobacter pylori. Whatdrug is it?

A. OmeprazoleB. GastrocepineC. MaaloxD. FamotidineE. Almagel

192. Quantitative determination of ni-trofural (furacilin) can be done by methodof spectrophotometry. A pharmacyanalyst can calculate quantity by measuri-ng:

A. Optical densityB. Refractive indexC. Rotation angleD. pH of solutionE. Fusion temperature

193. An edema can be relieved bymeans of hypertonic solutions. Whatphenomenon takes place in the blood cellsafter injection of such solution?

A. PlasmolysisB. HydrolysisC. HemolysisD. LipolysisE. Electrolysis

194. A consulting pharmacist informeda patient about possible side effect ofmetronidazole that is normally provokedby alcohol intake. What is the mechanismof this phenomenon?


A. Enzyme alcohol dehydrogenase blocki-ngB. Enzyme alcohol dehydrogenase acti-vationC. Enzyme acetylcholinesterase blockingD. Enzyme acetylcholinesterase activationE. Enzyme glucose 6-phosphatedehydrogenase activation

195. An anaesthesiologist has to performan operation under neuroleptanalgesia.Which of the following drug combinati-ons should be used in this case?

A. Fentanyl with droperidolB. Droperidol with prednisoloneC. Fentanyl with diazepamD. Diazepam with aminazineE. Promedol with amitriptillin

196. Common juniper is applied as a di-uretic, anti-inflammatory and cholagogicagent. This plant gives the following medi-cinal raw material:

A. FruitsB. SproutsC. LeavesD. RootsE. Seeds

197. Which of the following reagentsshould be added to the isoniazid to achi-eve blue colour and precipitation thatturns light-green and emits gases whenheated?

A. Copper sulfate solutionB. Silver nitrate solutionC. Alkaline solutionD. Hydrochloric acid solutionE. Iron (III) chloride solution

198. For accounting business transactions

carried out in a pharmacy the syntheticaccounts are used. Their list is given inthe Chart of Accounts. Balances of theI, II and III account classes are used forcompletion of the following document:

A. AssetsB. Profit and Loss AccountC. LiabilitiesD. First section of the liabilities balancesheetE. Fourth section of the liabilities balancesheet

199. A 40-year-old patient suffers frombronchial asthma and cardiac rhythm di-sturbance in form of bradyarrhythmia.Drugs of which pharmacological groupshould be administered for bronchospasmsuppression?

A. M-cholinergic antagonistsB. Beta-blockersC. M-cholinomimeticsD. Cholinesterase inhibitorsE. Muscle relaxant

200. A patient who has taken phenobarbi-tal for a long time was prescri-bed diclofenac sodium. However theanti-inflammatory effect of diclofenacappeared to be less than expected due tothe pharmacokinetic interaction of thesedrugs. Such interaction might be the resultof the following processes:

A. Accelerated drug metabolism in liverB. Decelerated drug metabolism in liverC. Reduced protein concentration inplasmaD. Change of receptor sensibilityE. Increased drug dosage

Health & Medicine

Krok 2 - 2011 Question Paper (Pharmacy)