Over Hansje Pansje Kevertje en

het babybrein

Jan Buitelaar

Afdeling Cognitive

Neuroscience, Radboudumc

Karakter Kinder- en

Jeugdpsychiatrie

9 april 2015

https://www.youtube.com/watch?v=_JmA2

ClUvUY&sns=em

Social-communication

deficits

Fixated interests and

repetitive behaviours

Autism Spectrum Disorder

Inattention

Impulsivity/Hyperactivity

ADHD - Core Symptom Areas

ASD and ADHD are developmental disorders with early onset and strong persistence over time

Autism Spectrum Disorder versus ADHD

ASD

• Onset before age 3

• >90% persistence into

adulthood

ADHD

• Onset before age 12

• About 50% have onset at 2-3 year

• 70% persistence into adolescence

• 30-50% persistence into

adulthood

ASD and ADHD are developmental disorders with early onset and strong persistence over time

Autism Spectrum Disorder versus ADHD

ASD

• Onset before age 3

• >90% persistence into

adulthood

ADHD

• Onset before age 12

• About 50% have onset at 2-3 year

• 70% persistence into adolescence

• 30-50% persistence into

adulthood

Total prevalence of early onset

neurodevelopmental disorders (ASD,

ADHD, language disorders, intellectual

diasability etc) is 15% !

Trends in Cognitive Science, 2009

These neurodevelopmental disorders are thought to

result from the disruption of normal brain development

and related neurobiological mechanisms during the

prenatal and early postnatal period.

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High-risk infants

• Develop ASD (1)

• Do not develop ASD (2)

High-risk

(20% risk for ASD)

• (3)Controls

(1% risk for ASD)

High-risk infantsContrasts that will be analysed:

• High-risk (1 en 2) versus controls (‘trait’)

• ASD (1) versus controls (‘state’)

• High-risk but no-ASD (2) versus ASD (1) (protective factors?)

Hansje Pansje Kevertje en andere

kinderliedjes

https://www.youtube.com/watch?v=LEjcYIs4PEw

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EEG

• Spontaneous EEG during social and non-social events

BASIS - EUROSIBS

EU-AIMS - BASIS

Naturalistic social attention

Social orienting and visual foraging(10m, 14m; Task 2)

0,25

0,3

0,35

0,4

0,45

0,5

0,55

0,6

0,65

0,7

Car Bird ScrambledFace

Phone Face Blank Overall

LR

HR-no ASD

HR-ASD

Ave

rage

fix

atio

n d

ura

tio

n (

s)

*

Wass, Jones et al., submitted

Wrist sensor

Skin conductance

Temperature

Acceleration

Gap attention-shifting

• Elsabbagh et al.,

20130

100

200

300

400

7-m 14-m .

Overlap-Ba

seline(m

s)

Control

At-risktypical

At-riskother

At-riskASD

Orekhova et al., in press

Other example outputs:

• Jones, Gliga, Bedford, Charman & Johnson (2014)

Neuro Biobehav Rev

• Johnson, Gliga, Jones & Charman, (in press) J

Child Psychol Psychiatry

• Johnson, Jones, Gliga & Charman (in press) Dev

Psychopath

• Kyllainen, Jones, Gomot, Warreyn & Falck-Ytter

(2014) Rev Autism Dev Disabilities

Low Risk High Risk – no ASD High Risk - ASDdbWPLC

Page 20

0 1 2 3 4 5 6 7 8

ADI Repetitive Behavior

0.0

0.01

0.02

0.03

0.04

0.05

0.06

0.07

0.08

Gra

nd

avera

ge d

bW

PLI

0 5 10 15 20 25 30 35 40

ADI Social and Communication

0.0

0.01

0.02

0.03

0.04

0.05

0.06

0.07

0.08:

Gra

nd

avera

ge d

bW

PLI

0 1 2 3 4 5 6 7 8

ADI Repetitive Behavior

0.0

0.04

0.08

0.12

0.16

0.20

db

WPLI a

vera

ged

over co

nn

ect

ion

s

that w

ere

incr

ease

d in

HR-A

SD

com

para

tive to b

oth

LR a

nd

HR-n

o-A

SD

Infant neural sensitivity to

dynamic eye gaze is

associated with later

emerging autism

Elsabbagh et al. Current Biology 2012

Detection of biological motion

EU-AIMS - BASIS

Atypical brain function precedes the

onset of over behavioral signs and

subsequently symptoms of ASD (and

ADHD)

Implications

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Early diagnosis

Early intervention

Prevention