11th MEET THE PROFESSOR

Advanced InternationalBreast Cancer CoursePADUA, SEPTEMBER 10th-11th-12th, 2015

DirectorsPier Franco Conte, Gabriel N. Hortobagyi

SECTION OF ONCOLOGY

Breast cancer represents the front runner in cancer research in many aspects. First, this is a common, chronic and lethal disease where medical interventions are successfully inducing a continuous decline in mortality in spite of increasing incidence. Second, biology drives the entire diagnostic-therapeutic work up of these patients. This is why, nowadays, a breast multidisciplinary team should also include pathologists, molecular biologists, oncogeneticists besides the “classic” clinical specialties. Third, many highly effective interventions are available for each step of the diagnostic and therapeutic work-up of these patients. The increased complexity of the disease, the availability of multiple effective choices and the high expectations of our patients are raising the bar of clinical excellence in this field.With this goal in mind, the Programme of this international Conference includes lectures on molecular characterization, updated treatments of early and advanced disease, management of difficult cases and hereditary syndromes. Clinical case discussions and debates are planned to allow a continuous and fruitful exchange of experiences and opinions between speakers and participants.This 11th Breast Cancer Conference includes a highly qualified international faculty, but will maintain its characteristics of a friendly forum where international opinion leaders and attendees will exchange experiences and share the most exiting advances.In order to reward scientific excellence and to foster international cooperation, the International Scientific Committee of the 11th AIBCC will award the 5th

International Prize for Breast Cancer Research to a scientist who has published a breakthrough paper in the previous year.We welcome medical oncologists, pathologists, breast surgeons, radiation oncologists and basic scientists to listen to breast cancer leaders and to exchange experiences in a friendly atmosphere.

Presentation

Gynaecologists and obstretrics, medical oncologists, pathologists, radiation oncologists, radiologists, surgeons; biologists and nurses.

Addressed to

Thursday, September 10th

8.00 Registration

8.45 Introduction to the Conference Pier Franco Conte, Gabriel N. Hortobagyi

SESSION I – LIFE STYLE AND BREAST CANCER Chairmen: Gabriel N. Hortobagyi, Manuel Zorzi

9.00 Prevention of breast cancer with life style changes and drugs Alessandra Gennari

9.20 Life style after breast cancer diagnosis Giovanna Masala

9.40 Fertility and breast cancer Fedro Peccatori

10.00 Q&A

10.30 Coffee break

SESSION II – GENETIC TESTING Chairmen: Alberto Amadori, Sibylle Loibl

11.00 BRCA: from genetic to predictive test Andrew Tutt

11.30 BRCA: germline versus somatic mutations Claude Houdayer

12.00 In and around the BRCA genes: the clinical relevance of variants of unknown significance and genetic modifiers

Marco Montagna

12.30 Multiplex germline mutation assays: ready for clinical use? Gabriel N. Hortobagyi

13.00 Q&A

13.15 Lunch

SESSION III – PATHOLOGY AND GENOMICS Chairman: Gabriel N. Hortobagyi

14.15 “Liquid biopsy”: CTCs, ctDNA, microRNA – Ready for prime time? François Clement Bidard

Programme

14.45 Clinical validity versus clinical utility of genomic tests Aleix Prat

15.15 Discordant pathology and genomic data: what should drive the therapeutic choice?

Giuseppe Viale

15.45 Q&A

16.00 Coffee break

CUP syndrome– Clinical Case Discussion I Chairmen: Fernando Bozza, Pier Franco Conte

16.30 CUP cases will be presented and the audience will be asked to vote on different options

Presenter of the cases: Maria Vittoria Dieci

17.10 A panel composed by pathologists, radiologists, surgeons and medical oncologists will discuss the votes of the audience and express their opinions (Hesham Ahmed Gaballah Elghazaly, Carlos A. Garcia-Etienne, Gabriel N. Hortobagyi, Sibylle Loibl, Luigi Pescarini, Philip Poortmans, Corrado Tinterri)

18.00 Adjourn

Friday, September 11th

Imaging – Clinical Case Discussion II Chairmen: Pier Franco Conte, Luigi Pescarini

8.30 Problematic/difficult cases of breast imaging will be presented. The presenters will ask the audience to express their opinion (voting system)

Presenters of the cases: Alessandro Coran

8.50 A panel composed by radiologists, surgeons and clinicians will express their opinions and comment on the audience voting (Riccardo Audisio, Hesham Ahmed Gaballah Elghazaly, Carlos A. Garcia- Etienne, Gabriel N. Hortobagyi, Luigi Pescarini, Philip Poortmans, Corrado Tinterri)

Axillary Staging– Clinical Case Discussion III Chairmen: Pier Franco Conte, Massimo Rugge

9.30 Cases of early breast cancer patients will be presented: extensive DCIS without infiltrating carcinoma, DCIS with multiple micro-filtrating foci, infiltrating carcinoma with micrometastatic SN, infiltrating carcinoma with different biologies with macrometastatic SN. The audience will be asked to vote on different options

Presenter of the cases: Tania Saibene

9.50 A panel composed by pathologists, surgeons, medical and radiation oncologists will discuss the votes of the audience and express their opinion (Riccardo Audisio, Pier Franco Conte, Hesham Ahmed Gaballah Elghazaly, Carlos A.Garcia-Etienne Gabriel N. Hortobagyi, Sybille Loibl, Enrico Orvieto, Philip Poortmans, Corrado Tinterri, Giuseppe Viale)

10.30 Coffee break

SESSION IV – SURGERY & RADIOTHERAPY Chairmen: Sibylle Loibl, Donato Nitti

11.00 Oncoplastic surgery: opportunities and challenges Riccardo Audisio

11.30 Risk reducing surgery: role in BRCAmut and BRCAwt patients Corrado Tinterri

12.00 Update on radiation therapy (hypofractionation, boost, IORT, postmastectomy radiotherapy)

Philip Poortmans

12.30 Q&A

12.45 Lunch

SESSION V – PREMENOPAUSAL EARLY BREAST CANCER Chairman: Gabriel N. Hortobagyi

13.45 Management of very young patients Sibylle Loibl

14.15 Adjuvant endocrine therapy after SOFT and TEXT trials Marco Colleoni

14.45 Management of endocrine and sexual problems in young patients Giovanbattista Nardelli, Salvatore Gizzo

15.15 Pregnancy after breast cancer Lucia Del Mastro

15.45 Q&A

17.30 Ceremony for the presentation of the University of Padua Award for Advances in Breast Cancer 2015

18.00 Lecture of the Awardee

18.30 Cocktail

The Ceremony and the cocktail will take place in palazzo Bo, Via VIII Febbraio 2, Padua

Saturday, September 12th

SESSION VI – NEW THERAPEUTIC ALGORITHMS FOR ABC PATIENTS Chairmen: Pier Franco Conte, Gabriel N. Hortobagyi

9.00 HR+ ABC Stephen Johnston

9.30 HER2+ ABC Valentina Guarneri

10.00 Triple negative advanced breast cancer Miguel Martin

11.00 Coffee break

11.30 Immunity and triple negative breast cancer Peter Schmid

12.00 Immunity and HER2+ BC Gianpaolo Bianchini

12.30 New promising check-point immunomodulators in solid tumors Filippo De Braud

13.00 From development to access: how to harmonise sustainability, equanimity and innovation Jonas Bergh

13.30 Q&A

14.30 Adjourn and final evaluation questionnaire

Pier Franco ConteDivision of Medical Oncology 2Istituto Oncologico Veneto IRCCS Department of Surgery, Oncology and GastroenterologyUniversity of Padua (I)

Gabriel N. HortobagyiDepartment of Breast Medical OncologyUniversity of Texas MD Anderson Cancer CenterHouston (USA)

Directors

Scientific CommitteeJonas BerghDepartment of Oncology-PathologyKarolinska Institute and University HospitalStockholm (SW)

Hesham Ahmed Gaballah ElghazalyDepartment of Clinical Oncology and nuclear medicineUniversity of AinshamsCairo (EG)

Valentina GuarneriDivision of Medical Oncology 2 Istituto Oncologico Veneto IRCCS Department of Surgery, Oncology and GastroenterologyUniversity of Padua (I)

Jacek JassemDepartment of Oncology and RadiotherapyMedical University of Gdansk (PL)

Stephen JohnstonNIHR Biomedical Research Centre for CancerRoyal Marsden NHS Foundation Trust & Institute of Cancer ResearchLondon (UK)

Sibylle LoiblGerman Breast GroupDepartment of Medicine and ResearchUniversity of Frankfurt (D)

Miguel Martin Medical Oncology Service Hospital Universitario Gregorio Marañon Madrid (S)

Donato NittiDepartment of Surgery, Oncology and GastroenterologyUniversity of Padua (I)

Philip PoortmansPresident of ESTRODepartment of Radiation OncologyRadbound University Medical CentreNijmegen (NL)

Alberto AmadoriDivision of Oncological Molecular Diagnostic and Immunology Istituto Oncologico Veneto IRCCS Department of Surgery, Oncology and GastroenterologyUniversity of Padua (I)

Riccardo AudisioDepartment of SurgerySt Helens Teaching HospitalLiverpool (UK)

Jonas BerghDepartment of Oncology-PathologyKarolinska Institute and University HospitalStockholm (SW)

Giampaolo BianchiniDepartment of Medical Oncology San Raffaele HospitalMilan (I)

François-Clement BidardCancer FoundationCurie InstituteParis (F)

Fernando BozzaDivision of Breast SurgeryIstituto Oncologico Veneto IRCCS Padua (I)

Marco ColleoniDivision of Medical SenologyEuropean Institut of Oncology (IEO)Milan (I)

Pier Franco ConteDivision of Medical Oncology 2Istituto Oncologico Veneto IRCCS Department of Surgery, Oncology and GastroenterologyUniversity of Padua (I)

Alessandro CoranBreast Imaging UnitIstituto Oncologico Veneto IRCCS Padua (I)

Filippo De BraudDepartment of Clinical OncologyNational Cancer InstituteMilan (I)

Lucia Del MastroMedical Oncology A- Innovative therapies developmentNational Institute for Cancer ResearchGenoa (I)

Maria Vittoria DieciDivision of Medical Oncology 2 Istituto Oncologico Veneto IRCCS Department of Surgery, Oncology and GastroenterologyUniversity of Padua (I)

Hesham Ahmed Gaballah ElghazalyUniversity of AinshamsDepartment of Clinical Oncology and Nuclear MedicineIl Cairo (E)

Carlos A. Garcia-EtienneDivision of Breast SurgeryS. Matteo Hospital Pavia (I)

Alessandra GennariDepartment of Medical OncologyGalliera HospitalGenova (I)

Salvatore GizzoDepartment of Gynecology and ObstetricsUniversity HospitalPadua (I)

Valentina GuarneriDivision of Medical Oncology 2Istituto Oncologico Veneto IRCCS Department of Surgery, Oncology and GastroenterologyUniversity of Padua (I)

Gabriel N. HortobagyiDepartment of Breast Medical OncologyThe University of Texas - MD Anderson Cancer CenterHouston (USA)

Speakers

Claude HoudayerDepartment de Biologie des Tumeurs - Service GenetiqueInstitut CurieParis (F)

Stephen JohnstonNIHR Biomedical Research Centre for CancerRoyal Marsden NHS Foundation Trust & Institute of Cancer ResearchLondon (UK)

Sibylle LoiblGerman Breast GroupDepartment of Medicine and ResearchUniversity of Frankfurt (D)

Miguel Martin Medical Oncology Service Hospital Universitario Gregorio Marañon Madrid (S)

Giovanna MasalaMolecular and Nutritional Epidemiology UnitCancer Research and Prevention Institute-ISPOFlorence (I)

Marco MontagnaHereditary Tumors Group Breast and Ovary CancerDepartment of Oncological Molecular Diagnostic and Immunology Istituto Oncologico Veneto IRCCS University of Padua (I)

Giovanni Battista NardelliDepartment of Gynecology and ObstetricsUniversity HospitalPadova (I)

Enrico OrvietoGeneral Pathology & Cytopathology UnitDepartment of Medicine-DIMED University of Padua (I)

Fedro PeccatoriDepartment of Medical OncologyEuropean Institute of OncologyMilan (I)

Luigi PescariniDepartment of RadiologyDiagnostic Breast UnitIstituto Oncologico Veneto IRCCSUniversity of Padua (I)

Philip PoortmansPresident of ESTRODepartment of Radiation OncologyRadbound University Medical CentreNijmegen (NL)

Aleix PratInstitute of Oncology (VHIO)Vall d’HebronBarcellona (E)

Massimo RuggeGeneral Pathology & Cytopathology UnitDepartment of Medicine-DIMEDUniversity of Padua (I)

Tania SaibeneDivision of Breast SurgeryIstituto Oncologico Veneto IRCCSPadua (I)

Peter SchmidCentre for Experimental Cancer MedicineBart Cancer InstituteQueen Mary UniversityLondon (UK)

Corrado TinterriDepatment of SenologyHumanitas Clinical InstituteRozzano (I)

Andrew TuttBreast Cancer Research UnitKings CollegeLondon (UK)

Giuseppe VialeDepartment of PathologyEuropean Institute of OncologyUniversity of Milan (I)

Manuel ZorziCancer Registry of VenetoPadova (I)

AwardsUNIVERSITY OF PADUA AWARD FOR ADVANCES IN BREAST CANCER 2015

The Scientific Committee will select young researchers (< 40 years from any country) who have published in an international peer-reviewed journal, as the principal author, a manuscript reporting important clinical or biological advances in breast cancer. Prof. Conte and Prof. Hortobagyi will select the final winner which will be invited to present his/her study during the annual Conference

Under 35Free admission is available for 3 persons “Under 35”. Registration forms will be accepted on a first-come, first-served basis until spaces are filled. The Organization Secretariat will confirm the registration by email.

Un’azione sostenibile a favore della formazioneIscrizione gratuita per i medici UNDER 35 fino a esaurimento posti

CMEBased on the in force Italian regulations, Accademia Nazionale di Medicina (provider n. 31) will assign to the activity CME (31-130969): 9,5 CME points.

The Meeting is addressed to physicians specialized in: gynaecology and obstretrics, oncology, pathology, radiodiagnostics, radiotherapy, general surgery; biologists and nurses.

It will not be possible to give credits to physicians specialized in different fields.

The credit certification is subject to:• attendance at the entire Meeting• the completion of the meeting evaluation form• the completion of the final questionnaire (at least 75% of correct answers)

We would like to remind to participants that only 1/3 of CME credits acquired during the years 2014/2016 can come frome a sponsorship.

ESMO-Mora CreditsESMO-Mora accreditation to be provided.

Official LanguageThe official language of the Meeting is English. No simultaneous translation will be provided.

RegistrationThe registration fee is € 250,00 tax free.It includes the conference bag, the conference book and all coffee breaks and lunches. It does not include Hotel accomodation, dinners and travel expenses.

Under the article 54 T.U.I.R and within the limits set out therein, the costs of participation in this activity are deductible in determining self-employment income.

To register, please send:• registration form duly filled out (even when sponsored by a Pharmaceutical Company• privacy statement and consent to the use of personal data (as in the back of the form)• payment

to Accademia Nazionale di Medicina – Palazzina CUP II Piano, Via Massarenti 9, 40138 Bologna (fax 0039 051 6364605 – e.mail: info.bologna@accmed.org, within August 24th, 2015.

Registration quote can be paid by: non-transferable cheque addressed to Accademia Nazionale di Medicina; bank transfer addressed to: ACCADEMIA NAZIONALE DI MEDICINA, Banca Prossima Spa - IBAN code: IT 35 Q0335901600100000121744 - SWIFT code: BCITITMX (indicate: “Registration of Dr. ... at Course 15_RE_ 1257); Credit Card Details Mastercard. Visa, Eurocard (NO AMEX cards).

Online registration is possible on the website http://meettheprofessor.accmed.org

By submitting the form and the payment, your registration is completed with the exception of specific decisions of the Meeting Secretariat.Incomplete registration will NOT be admitted.The registration will be confirmed by e-mail, please put your e-mail address on the registration form.

CANCELLATION• if the participants minimum number is not reached, Accademia Nazionale

di Medicina will advise by a written communication and proceed with the total refund of the fee.

• In order to cancel please give advise with a written communication to Accademia Nazionale di Medicina within 10 days from the beginning. A 70% of the registration fee will be returned. Any cancellation after that deadline will not be reimbursed.

Meeting VenueCentro Congressi Padova A. LucianiVia Forcellini 170/APadovaTel. +39 049/8033711

How to reach the meeting venue:

By Car:The Highway exits arePadova Est, 5 Km from the Meeting VenuePadova Zona Industriale, 6 Km from the Meeting Venue

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By PlaneVenezia Airport - Marco-Polo: 43 km (about 40 minutes by car)Treviso Airport- Canova: 63 km (about 50 minutes by car)

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