INTRODUCTION

METHODS

LITESSE® POLYDEXTROSE MODIFIES APPETITE AND REDUCES CALORIE INTAKE

1DuPont Nutrition & HealthActive NutritionSokeritehtaantie 2002460 KANTVIK, FINLANDE-mail: alvin.ibarra@dupont.com

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Litesse® polydextrose is a high-soluble and low-calorie dietary fibre, 1kcal/g. Several studies have reported that the consumption of Litesse® can suppress subjective feelings of appetite and reduce subsequent voluntary calorie intake levels. In a systematic review and meta-analysis we examined the effects of the consumption of Litesse® on these parameters[1,2].

The review followed the PRISMA methodology. A search for studies that investigated the effects of the consumption of polydextrose on subjective feelings of appetite and calorie intake at a subsequent meal was conducted. A new methodology was proposed to analyze subjective feelings of appetite during the Satiation and Satiety periods. The meta-analysis was expressed as Standardized Mean Difference (SMD, 95% CI). Linear regression was used to determine whether the model defined calorie intake as a function of the Litesse® dose.

Ibarra A1, Stenman L1, Astbury NM2, Olli K1, Alhoniemi E3, Tiihonen K1

RESULTS Figure 1. Litesse® polydextrose reduces the Desire to Eat during Satiation. Doses: [L], 6.3 g/d; [M], 12.5 g/d; [H] >25g/d.

CONCLUSIONSThe studies included in this meta-analysis support the notion that the consumption of Litesse® suppresses appetite and reduces voluntary calorie intake at a subsequent meal. Furthermore, the reduction in calorie intake occurs in a dose dependent manner.

2University of OxfordNuffield Department of Primary Care Health SciencesOxford, United Kingdom

Schwab et al. [18] (Week 12) (16.0 g)Schwab et al. [18] (Week 0) (16.0 g)

Olli et al. [11] (15.0 g)Astbury et al. [15] (6.3 g)Astbury et al. [15] (12.5 g)Astbury et al. [15] (25.0 g)Ranawana et al. [16] (12.0 g)Hull et al. [17] (6.25 g)Hull et al. [17] (12.5 g)Astbury et al. [12] (25.0 g)

Less Desire to Eat with Litesse®

Our new methodology for assessing subjective feelings of appetite allowed us to conduct a meta-analysis showing that Desire to Eat during the Satiation period favors Litesse® for the reduction of this subjective feeling of appetite (SMD=0.24, I2<0.01, P=0.018), Figure 1. In addition, Litesse® also tends to reduce Hunger and increase Satisfaction during the Satiety period.

The meta-analysis on the studies reporting levels of calorie intake indicate that the consumption of Litesse® was associated with a reduction in subsequent calorie intake (SMD=0.35, I2=0, P<0.01), Figure 2. Furthermore, the dose of Litesse® correlated significantly with the reduction in subsequent calorie intake (P<0.01), Figure 3.

Figure 3. The reduction in Calorie Intake is dose dependent. Subsequent Calorie Intake = -0.67 * Polydextrose dose (g/day) (P<0.01; R2=0.80).

Figure 2. Litesse® polydextrose reduces the Subsequent Calorie Intake. Doses: [L], 6.3 g/d; [M], 12.5 g/d; [H] >25g/d.

Random effects

−1.50 −1.00 −0.50 0.00 0.50 1.00 1.50 favors placebo favors polydextrose

King et al. 2005 (day 10) [H]King et al. 2005 (day 1) [H]Astbury et al. 2008 [H]Hull et al. 2012 [M]Hull et al. 2012 [L]Ranawana et al. 2013 [M]Astbury et al. 2013 [H]Astbury et al. 2013 [M]Astbury et al. 2013 [L]Astbury et al. 2014 [H]

0.52 [ −0.21 , 1.25 ]0.18 [ −0.54 , 0.89 ]0.39 [ −0.35 , 1.14 ]0.21 [ −0.27 , 0.68 ]0.14 [ −0.34 , 0.61 ]0.28 [ −0.26 , 0.83 ]0.80 [ 0.17 , 1.43 ]0.55 [ −0.07 , 1.16 ]0.38 [ −0.23 , 0.99 ]0.29 [ −0.59 , 1.17 ]

0.35 [ 0.16 , 0.54 ]

Study SMD [95% CI]

−25

−20

−15

−10

−5

low (6.25−6.3) medium (12−12.5) high (25) Polydextrose (g/day)

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Inta

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Less Calorie Intake with Litesse®

1. Ibarra et al. Effect of Polydextrose on Subjective Feelings of Appetite during the Satiation and Satiety Periods: A Systematic Review and Meta-Analysis. Nutrients 2016;8(1):45.2. Ibarra et al. Effects of Polydextrose on Different Levels of Energy Intake: A Systematic Review and Meta-Analysis. Appetite. 2015;87C:30-37.

3Avoltus OyTurku, Finland