ISSN 0036-80755 JUNE 1992VOLUME 256NUMBER 5062

AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE

1 3969 1 402, =%1416 & 1420RNA makes peptlde bonds

and that s not all

NEWS & COMMENTFuror at Lyme Disease ConferenceCalifornia Rides Its Own Bi-Cycle

Mission Impossible: Saving AllEndangered Species

Errant HIV Strain Renders Test VirusStock Useless

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NASA Researchers Protest DOE Turnoff 1388

Panel Clears Needleman of Misconduct 1389

Institute of Medicine Elects New Members 1389

WS........

Scoring a Technical Knockout in Mice r 1392Researchers Wrestle With Concerns OverCost and Access

Did an Asteroid Leave Its Mark in 1395Montana Bones?

Finding RNA Makes Proteins Gives 1396'RNA World' a Big Boost

Gammas From Heaven 1397

1 392 Knockoutmice find

& favor with

1 448 biologists

PERSPECTIVESNew Horizons for RNA CatalysisN. R. Pace

On the Other Hand ...G. A. Petsko

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F 1403

ARTICLESCrust Formation and Plate Motion in theEarly ArcheanA. Kroner and P. W. Layer

Human Organ Transplantation:Background and Consequences

J. E. Murray

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DEPARTMENTSTHIS WEEK IN SCIENCE

EDITORIALEconomic Impact Report

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LETTERS 1378The Smithsonian and Sheep Hunting: R. S.Hoffmann; E. Marshall * European Science:H. W. Mewes, S. Oliver, A. Goffeau; A. Anderson;A. A. Travers, A. Anderson * NIH Leaks:J. Schneider * Fear of Butterflies: A. M. Shapiro -Math Teaching, K-12: Relevant Expertise:S. Mac Lane

SCIENCESCOPE 1383Needles shoot down ADAMHA reorganization, etc.

RANDOM SAMPLES 1390An OTA for Parliament * Parkinson's ProgresseBirth Control for Animals, etc.

BOOK REVIEWS 1464A Space for Science, reviewed by D. Serwer * SomeOther Books of Interest * Vignettes: Popular Images* Books Received

PRODUCTS & MATERIALS 1467

.AAAS Board of Directors- .:Board of Reviewing Editors.

Leon M. LedermanRetiring President,Chairman

F. Sherwood RowlandPresident

Eloise E. ClarkPresident-elect

Mary Ellen AveryFrancisco J. AyalaRobert A. Frosch

Florence P. HaseltineAlan SchriesheimJean'ne M. ShreeveChang-Lin TienWarren M. Washington

William T. GoldenTreasurer

Richard S. NicholsonExecutive Officer

John AbelsonFrederick W. AltDon L. AndersonStephen J. BenkovicDavid E. BloomFloyd E. BloomHenry R. BourneJames J. BullKathryn CalameC. Thomas CaskeyDennis W. Choi

John M. CoffinBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. FearonHarry A. FozzardVictor R. FuchsTheodore H. GeballeMargaret J. GellerJohn C. GerhartRoger 1. M. Glass

Stephen P. GoffCorey S. GoodmanStephen J. GouldIra HerskowitzEric F. JohnsonStephen M. KosslynMichael LaBarberaCharles S. Levings IllHarvey F. LodishRichard LosickAnthony R. Means

Mortimer MishkinRoger A. NicollWilliam H. Orme-Johnson IllStuart L. PimmYeshayau PockerDennis A. PowersRalph S. QuatranoV. RamanathanErkki RuoslahtiRonald H. SchwartzTerrence J. Sejnowski

Thomas A. SteitzRichard F. ThompsonRobert T. N. TjianEmil R. UnanueGeerat J. VermeijBert VogelsteinHarold WeintraubZena WerbGeorge M. WhitesidesOwen N. WitteKeith Yamamoto

SCIENCE * VOL. 256 * 5 JUNE 1992

ScIENCE

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