ISSN 0036-807531 JULY 1992VOLUME 257NUMBER 5070

AMERICANASSOCIATION FOR THEADVANCEMENT OFSCIENCE

NEWS & COMMENT

New Virus Reports Rile AIDS Meeting 604«j)~Progress on Other Fronts

Human SIV Infections Suspected 606

Germany: Astrophysics Institute at Risk 606

Bad News on Second-Hand Smoke 607

Frustrated EMBL Chief Resigns 607

A Scramble for Data on Arctic 608Radioactive Dumping

,eIAn NSF Survey Rattles Some Nerves 609

RESEARCH NEWSTrapping Particles of Darkness 610

A Match Made in Laser Heaven 611

The Earliest Mass Extinction? 612

Forcing the Evolution of an RNA r 613Enzyme in the Test Tube

Adhesion Protein Studies Provide New ° 614Clue to Metastasis

SPECIAL NEWS REPORTCONFLICTS OF INTEREST

Confusion on the Cutting Edge 616Joumal-istic Guidelines * Not Merely Academic

When Does Intellectual Passion Become 620Conflict of Interest?Sex on the Brain * The Perils of a Deeply HeldPoint ofView * Small Comets/Big Flap

NSF Deals With Conflicts Every Day 624

Intellectual Conflicts-Boon or Bust? 624

Conflicting Views: The Readers Respond 625

PERSPECTIVEThe Logic of Cell Division in the Life 626Cycle of YeastC. J. Gimeno and G. R. Fink

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Structural Processes at Slow-Spreading 627Ridges

J. C. Mutter and J. A. Karson

DRAAAS Board of Dire

Leon M. Lederman FlorenceRetiring President, Alan SchrChairman Jean'ne M

F. Sherwood Rowland Chang-LirPresident Warren M

Eloise E. ClarkPresident-elect William T.

Mary Ellen Avery TreasurFrancisco J. Ayala Richard SRobert A. Frosch Erecut

aCtors BmBP. Haseltineiriesheimd. Shreevein TenA. Washington

r.GoldenirerNicholson

tive Officer

John AbelsonFrederick W. AltDon L. AndersonStephen J. BenkovicDavid E BloomFloyd E. BloomHenry R. BoumeJames J. BullKathryn CalameC. Thomas CaskeyDennis W. Choi

John M. CoffinBruce F. EldridgePaul T. EnglundRichard G. FairbanksDouglas T. FearonHarry A. FozzardVictor R. FuchsTheodore H. GeballeMargaret J. GellerJohn C. GerhartRoger 1. M. Glass

oard of Reviewing Editorsii iiiiiiiiii

Stephen P. Goff Mortimer MishkinCorey S. Goodman Roger A. NicollStephen J. Gould William H. Orme-Johnson Ill

Ira Herskowitz Stuart L PimmEric F. Johnson Yeshayau PockerStephen M. Kosslyn Dennis A. PowersMichael LaBarbera Ralph S. QuatranoCharles S. Levings Ill V. RamanathanHarvey F. Lodish Erkki RuoslahtiRichard Losick Ronald H. SchwartzAnthony R. Means Terrence J. Sejnowski

Thomas A. SteitzRichard F. ThompsonRobert T. N. TjianEmil R. UnanueGeerat J. VermeijBert VogelsteinHarold WeintraubZena WerbGeorge M. WhitesidesOwen N. WitteKeith Yamamoto

SCIENCE * VOL. 257 * 31 JULY 1992

SCIENCE

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COVERCoral skeleton of the genus Favia. Scleractinian coralssecrete a hard skeleton composed of aragonite(CaCO3), which incorporates strontium along withcalcium in a ratio that depends on sea-surface tempera-ture. Recent findings suggest that for corals of the

genus Porites this dependence may be used to recoverrecords of Pleistocene and Holocene sea-surface tem-peratures with an apparent accuracy of better than O.50C.See page 644. [Photomicrograph: J. W. Beck]

RESEARCH ARTICLEDirected Evolution of an RNA Enzyme F 635A. A. Beaudry and G. F. Joyce

REPORTSTransfer of Biologically Derived 642Nanometer-Scale Patterns to Smooth SubstratesK. Douglas, G. Devaud, N. A. Clark

Sea-Surface Temperature from Coral 644Skeletal Strontium/Calcium Ratios

J. W. Beck, R. L. Edwards, E. Ito, F. W. Taylor,J. Recy, F. Rougerie, P. Joannot, C. Henin

Maintenance of Strong Rotational 647Winds in Venus' Middle Atmosphere byThermal TidesM. Newman and C. Leovy

Elasticity of a-Cristobalite: A Silicon 650Dioxide with a Negative Poisson's RatioA. Yeganeh-Haeri, D. J. Weidner, J. B. Parise

The Location of Bound Lipid in the 652Lipovitellin ComplexP. A. Timmins, B. Poliks, L. Banaszak

Vacuolar Chitinases of Tobacco: A New 655Class of Hydroxyproline-Containing ProteinsL. Sticher, J. Hofsteenge, A. Milani, J.-M. Neuhaus,F. Meins, Jr.

Calcium-Dependent Transmitter SecretionReconstituted in Xenopus Oocytes:Requirement for Synaptophysin

S. Alder, B. Lu, F. Valtorta, P. Greengard,M.-m. Poo

Functional Modulation of GABAAReceptors by cAMP-Dependent ProteinPhosphorylationS. J. Moss, T. G. Smart, C. D. Blackstone,R. L. Huganir

657

661

Neuronal Domains in DevelopingNeocortexR. Yuste, A. Peinado, L. C. Katz

Chloride-Dependent CationConductance Activated During CellularShrinkageH. C. Chan and D. J. Nelson

Mechanistic Aspects of SignalingThrough Ras in NIH 3T3 CellsK. Zhang, A. G. Papageorge, D. R. Lowy

665

669

671

Repression of the Insulin-Like Growth 674Factor II Gene by the Wilms TumorSuppressor WTl

I. A. Drummond, S. L. Madden, P. Rohwer-Nutter,G. I. Bell, V. P. Sukhatme, F. J. Rauscher III

Specialized Role for a MurineClass I-b MHC Molecule in ProkaryoticHost DefensesR. J. Kurlander, S. M. Shawar, M. L. Brown,R. R. Rich

A Protein Kinase Substrate Identified bythe Two-Hybrid SystemX. Yang, E. J. A. Hubbard, M. Carlson

678

680

Participation in Normal Immune ° 682Responses of a Metastasis-Inducing SpliceVariant of CD44R. Arch, K. Wirth, M. Hofmann, H. Ponta,S. Matzku, P. Herrlich, M. Zoller

Cl Indicates accompanying feature

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