Genome sequencing for animal health – input and impact
Gwenaelle DAUPHINAGAH – EMPRES
Lab Unit coordinator
Running PCR
Obtaining genetic sequence
Analysing and sharing
Monitoring virus distribution
Monitoring virus genetic evolution
Monitoring vaccine matching
More powerful molecular epidemiology
Better design of diagnostic assays
Improved veterinary vaccination
Molecular DIVA for CapripoxvirusesCapripoxvirus Genotyping
Whole genome phylogenetic analysis of Capripoxviruses
Whole genome sequencing
Outcomes and impact in Indonesia: Influenza Virus Monitoring Network
Informed Avian influenza control policies, including vaccination
Improved knowledge of circulating H5N1 viruses
Clear process to support decision making
Endemic with influenza H5N1 since 2004: -3,500 poultry H5N1 outbreaks reported-1,150 Egyptian influenza H5N1isolates from poultry which sequences = deposited to the public domain
Outcomes and impact in Egypt
Phylogenetic analysis of A(H5N1) in Egypt during 2006-2014
Conclusions• Sequence data: key component in the control and prevention of animal and zoonotic
diseases• Molecular biology used in all countries - use of sequencing is expanding – high
demand for training• Sharing of sequences of utmost importance
active in building capacities, assisting countries to apply sequencing and promoting the use and sharing of sequences