BioMicroLab

Sample Management Automation

Tube and Vial Handling

Volume

Verification

SampleScan 2D

barcode readers

About BioMicroLab

BioMicroLab’s parent company: CopyPro, Inc. 20-year track record in manufacturing material handling products

Modern CNC sheet metal/machined metal production systems

In-house engineering team

Focus: Industrial products with easy-to-use software

Holds several US Patents

BioMicroLab’s history 2001 - XL20 Tube Handling Instrument development begins

2003 - BioMicroLab incorporates

2004 - XL20 launched at Lab Automation Conference

2004 - Released 2D tube rack and single tube readers

2005 - XL9 Tube Handler introduced

2006 - Launched SampleScan HS and VolumeCheck at Lab

Automation 2006

2007 – Shipped 100th XL20 Tube Handling System

2008 – Released XL100 Vial Handling Instrument

2009 – Introduced the SampleScan Mini and SampleScan Plus

2010 – Released Decapper and Automated Capper for XL100

2011 – Added Liquid Handling to the XL100

Typical BioMicroLab Customers

• Compound Sample Management Laboratory

– Large Pharmaceutical Companies

• Bench top automation for central sample repositories

– Small and Large Biotech Companies

• Main robot for handling laboratory sample libraries

• Genomic Research Facilities

– Usually research departments at Hospitals and Universities

• Genomic Core Facilities

• Tissue Banks

• DNA Banks

• BioBanks

BioMicroLab Customers

Sample Management Automation

Tube Handling Instruments

– XL20 Tube Handling Instrument

– XL9 Tube Handling Instrument

– XL100 Vial Handling Instrument

– MX4 Sort and Scan

SampleScan 2D Readers

– SampleScan 96 – multi-rack reader

– SampleScan Plus – single tube reader

– SampleScan HS – camera based high speed reader

– SampleScan Mini – scanner based high speed reader

Volume Verification Instruments

– VolumeCheck – ultrasonic detection of sample in well plates

– XL20 Automated Balance – gravimetric volume tracking

– XL20 LevelCheck – sensor detects sample meniscus in capped vials

BioMicroLab Tube Handlers

XL20 Tube Handler

XL9 Tube Handler

XL100 Vial Handler

MX4 Sort and Scan

VolumeCheck

VolumeCheck – Volume Verification Instrument

SampleScan 2D Barcode Readers

SampleScan Plus Single Tube Reader

SampleScan Mini Single Rack Reader

SampleScan HS Single Rack

High Throughput

SampleScan Mini with1D reader Fully Automated Single Rack Reader

SampleScan 96 Entry-Level

Single Rack Scanner

XL20 Tube Handling Instrument

XL9 Tube Handling Instrument XL20 Tube Handling Instrument

XL20 Tube Handler Applications

Key XL20 applications

Automated analytical balance used to confirm sample volume

Automated tube sorter to manage handling of sample libraries

Typical applications

Cherry Picking tubes

Re-arraying sample libraries

Handling samples from combinational chemistry labs

Weighing tubes to calculate sample volume

LevelCheck tubes for fast volume data return

Workflow Application

XL20 Features & Benefits

Features

- Small bench top robot for 96 tube sample format

- Processes 0.3 ml to 1.4 ml tubes from Micronic, ABgene, Corning, & MATRIX

- Automates tube sorting, 2D scanning, and weighing

- Faster & less costly than competing automated balances

- Quick integration & deployment (operational the day of installation)

Benefits

- Saves time and resources

- Extend laboratory’s sample

tracking capabilities

- Leverages laboratory’s investment

in 2D tube storage systems

- Ease-of-use allows operation by a

wide variety of users

XL20 Hardware Options

XL20 Instrument Options

2D barcode reader module

Integrated single tube reader

Decodes 2D marked tubes while sorting

Analytical Balance module

captures tube weight

0.0001g readability

Software application specific to net weight capture of tube sample

LevelCheck module

Non-contact sensor detects sample meniscus and returns volume data

2D Camera Option

2D Camera Module

Scans and decodes 2D

barcoded vials

Captures 2D barcode while

processing tubes

Module does not use tube

rack nest

Analytical Balance Option

Analytical Balance

Weighing range 60g

Readability at the interface 0.0001g

Reproducibility = +/- 0.0001g

Linearity <= +/- .0002g

Response time average <= 2 sec

LevelCheck Option

LevelCheck Module for XL20/XL9 Non-Contact sample volume detection

Accuracy: +/- 10 – 15uL

Collects volume data while sorting, rearraying, and capturing 2D barcodes

LevelCheck one rack in about 15 minutes

Sample image and capture recall – store tube images with 2D barcode data

XL20 systems can be field upgraded with the LevelCheck system

No loss of sorting positions

when scale is present

LevelCheck uses tube rack position

#5 on XL20 sorting platform

XL9 Tube Handling Instrument

XL20 & XL9 robotics are identical

XL20 has 28.5” width and 20 rack positions

XL9 has 18” width and 9 rack positions

Workflow with BioMicroLab software

Work List Mode

LIMS (database)

Input .csv

XL20

Output .csv

1. Query for sample list

2. Create XL20 input

format (.csv)

3. XL20 imports and

sorts tubes

5. Import file for

LIMS database update

4. XL20 creates

output file for each

rack (.csv)

Workflow with ActiveX software

LIMS

(database) XL20

Query for sample list

XL20 sorts/weighs

tubes

Sorting data

automatically updates

LIMS

Note: ActiveX requires customer IT group provide database integration software support.

XL20 Work List Manager Software

XL Tube Handler Processing Modes

Tube Handler modes of operation • Work List Based – rearray applications

1. Sequential

• Racks are processed in work list order

only

2. Random

• Racks are processed in random order

• No Work List Required – pick and place vial from same

location

1. Tare/Gross Weigh

• Tare and gross weight of vials

• Streamlined weighing mode

2. Data Collection Mode

• Typically used to collect linear barcodes

or vial weight with XL100

XL20 Tube Handler Input Work List

Work list example

Source Rack ID

Source Tube Location

Expected Tube 2D bar

code (optional)

Target Rack ID

Target Tube Location

XL20 Tube Handler Software Features

Main Processing Screen

– Work list controlled movement of

tubes

– Confirms tube ID from work list

with captured 2D data

– Captures image of 2D barcode for

error handling

– Sample weight capture displayed

– Software generates Job ID for

tracking in your LIMS system

– Start, Stop, and Pause

Click to import

work list

Input File Settings

Input Files Settings

Provides flexibility for importing

work lists with header files or extra

characters

XL20 Tube Handler Tray Setup

Work List Software

– Assignment of racks to XL20

platform locations

– Color coded interface guides user

through tube rack loading process

– Supports input from hand held bar

code scanner

XL9 Tube Handling System displayed

XL20 Tube Rack Loading Process

Scanning the tube rack position

on XL20/XL9 platform

Scanning the barcode ID

label on the tube rack

XL9 Tube Handling System displayed

XL20 Tube Handler Software Features

To Start - press job

initiator button

Can view live video vs.

captured bitmap

Barcode Read

Returns decoded

barcode

Status column

OK

Bar code mismatch

Weight column

Returns weight

Captures data

while processing

tubes

XL20 Work List Mode Output File

Generates LIMS output file for use

by sample tracking systems

Operator can pre-determine content of

output file

Output file can be placed in folder on a

network

Example of Work List Processing

Mode Output

Example of Work List Mode Output File

LevelCheck Output

LevelCheck Output

Volume data output in .csv output file

Volume data associated with 2D barcode

via output file

Tube images output .JPEG

LevelCheck output file example LevelCheck visual inspection

XL20 Tube Handler Tare/Gross Weigh

Tare Gross Weighing Mode

Data Collection mode

Interactive selection of tube

positions during the weighing mode

set up

Provides full flexibility for a wide

variety of weighing applications

Tare/Gross Weigh Output File Options

Output File Options for

Tare/Gross Weigh Mode

Operator can pre-determine content

of output file

Output file can be placed in folder on

a network

Example of Work List Processing

Mode Output

Example of Tare/Gross Weigh Output File

XL20 Tube Handler Error Handling

Error handling for operations

Tube Movement:

Picking Tube

Placing Tube

Bar Code Decoding:

Barcode Miss-match

Decode failure

Error handling features selectable

by the operator

Audible Alarms

XL20 Tube Handler Robot Control

Manual control of robot via

loader control panel

Troubleshooting

Individual tube movements

Calibrate Scale

Calibrate Camera Option

XL20 Product Specifications

Operating Requirements:

Electrical: 110-220 VAC 60Hz

Environment: Ambient Room Model: 4 C to 40 C, 10-90% RH

Cold Room Model: -4 C to 40 C, 10-90% RH

Machine Specifications:

Weight: XL20 : 42 lbs

XL9: 22 lbs

Dimensions: XL20: 28.25" W x 21" L x 16" H

XL9: 18.00” W x 17” L x 16” H

XL20 Product Specifications

PC System Requirements:

Windows XP/Vista/7

2.2+ GHz computer processor

512MB RAM (1GB recommended)

Standard Serial and USB Ports

BioMicroLab Service and Support

BioMicroLab Service Support Center

– Concord, CA, USA

Service Offering

– Service Agreements

– Phone

– Email

– Library of technical data sheets

– Preventative Maintenance Service Program

Onsite Support

– BioMicroLab Direct

– Reseller support network

Contact Information

BioMicroLab, Inc.

Web: www.biomicrolab.com

Email: info@biomicrolab.com

Tel: (925) 689-1200 or Fax: (925) 689-1263

Mail: 2500-A Dean Lesher Drive

Concord, CA 94520 USA