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Volume 8, Number 1, January 2021 Neurology.org/NN A peer-reviewed clinical and translational neurology open access journal ARTICLE Seizure-related 6 Homolog Like 2 Autoimmunity e916 ARTICLE Overlapping Central and Peripheral Nervous System Syndromes in MOG Antibody–associated Disorders e924 VIEWS & REVIEWS Chitinases and Chitinase-like Proteins as Biomarkers in Neurologic Disorders e921 ARTICLE Overweight/Obesity in Young Adulthood Interacts With Aspects of EBV Infection in MS Etiology e912

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Page 1: With Aspects of EBV Infection in MS Etiology

Volume 8, Number 1, January 2021Neurology.org/NN

A peer-reviewed clinical and translational neurology open access journal

ARTICLE

Seizure-related 6 Homolog Like 2 Autoimmunity e916

ARTICLE

Overlapping Central and Peripheral Nervous System Syndromes in MOG Antibody–associated Disorders e924

VIEWS & REVIEWS

Chitinases and Chitinase-like Proteins as Biomarkers in Neurologic Disorders e921

ARTICLE

Overweight/Obesity in Young Adulthood Interacts With Aspects of EBV Infection in MS Etiology e912

Page 2: With Aspects of EBV Infection in MS Etiology

Academy OfficersJames C. Stevens, MD, FAAN, PresidentOrly Avitzur, MD, MBA, FAAN, President ElectAnn H. Tilton, MD, FAAN, Vice PresidentCarlayne E. Jackson, MD, FAAN, SecretaryJanis M. Miyasaki, MD, MEd, FRCPC, FAAN, TreasurerRalph L. Sacco, MD, MS, FAAN, Past President

CEO, American Academy of NeurologyMary E. Post, MBA, CAEChief Executive Officer201 Chicago AveMinneapolis, MN 55415Tel: 612-928-6100

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Adria Gottesman-Davis, PhD, Journal Editorial Manager

Morgan S. Sorenson, Managing EditorNeurology® Neuroimmunology & NeuroinflammationNeurology® Genetics

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Neurology® Neuroimmunology & Neuroinflammation (eISSN 2332-7812) is anopen access journal published online for the American Academy of Neurology,201 Chicago Ave, Minneapolis, MN 55415, by Wolters Kluwer Health, Inc. at14700 Citicorp Drive, Bldg 3, Hagerstown, MD 21742. Business offices arelocated at Two Commerce Square, 2001 Market St., Philadelphia, PA 19103.Production offices are located at 351 West Camden Street, Baltimore, MD21201-2436. © 2020 American Academy of Neurology.

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Page 3: With Aspects of EBV Infection in MS Etiology

A peer-reviewed clinical and translational neurology open access journal Neurology.org/NN

Neurology® Neuroimmunology & Neuroinflammation

EditorJosep O. Dalmau, MD, PhD

Deputy EditorScott S. Zamvil, MD, PhD, FAAN

Associate EditorsMarinos Dalakas, MD, FAANMichael Heneka, MDDennis Kolson, MD, PhDFriedmann Paul, MD

Editorial BoardSergio E. Baranzini, PhDSusanne Benseler, MDJeffrey L. Bennett, MD, PhD, FAANSeverine Boillee, PhDRiley M. Bove, MD, MMSCChiara Briani, MDFabienne Brilot, PhDMatthijs C. Brouwer, MD, PhDWolfgang Bruck, MDDavid B. Clifford, MD, FAANAnne Haney Cross, MDRussell C. Dale, MBChB, MRCP, PhDThomas G. Forsthuber, MDKazuo Fujihara, MDChristian Geis, MDJeffrey M. Gelfand, MD, MAS, FAANFrancesc Graus, MD, PhDKerstin Hellwig, MDMatilde Inglese, MD, PhDTakahiro Iizuka, MDLuisa Klotz, MD

Kristen M. Krysko, MD, MASAnnette Langer-Gould, MD, PhDFrank Leypoldt, MDErin Longbrake, MD, PhDAndrew McKeon, MDAnne Louise Oaklander, MD PhD,

FAAN, FANAAnne-Katrin Probstel, MDRichard M. Ransohoff, MDAlbert Saiz, MD, PhDJens Schmidt, MD, FEAN, FAANChristine Stadelmann, MDIsrael Steiner, MDLawrence Steinman, MDSilvia N. Tenembaum, MDCharlotte E. Teunissen, PhDMaarten J. Titulaer, MD, PhDAri Waisman, PhDGregory F. Wu, MD, PhD

Neurology® Journals

Editor-in-ChiefJose G. Merino, MD, MPhil, FAAN

Deputy EditorOlga Ciccarelli, MD, PhD, FRCP

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Classification of Evidence EvaluationsGary S. Gronseth, MD, FAAN

Equity, Diversity, & InclusionRoy H. Hamilton, MD, MS, FAANHolly E. Hinson, MD, MCR, FAAN

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Classification of Evidence Review TeamMelissa J. Armstrong, MDRichard L. Barbano, MD, PhD, FAANRichard M. Dubinsky, MD, MPH, FAANJeffrey J. Fletcher, MD, MScGary M. Franklin, MD, MPH, FAANDavid S. Gloss II, MD, MPH&TMJohn J. Halperin, MD, FAANJason Lazarou, MSc, MDSteven R. Messe, MD, FAANPushpa Narayanaswami, MBBS, DM, FAANAlex Rae-Grant, MD

Vision Neurology® Neuroimmunology &Neuroinflammation will be the premierpeer-reviewed journal in the fields ofneuroimmunology and neuroinflammation.

Mission Neurology: Neuroimmunology &Neuroinflammation will provide neurologistsand clinical research scientists withoutstanding peer-reviewed articles, editorials,and reviews to enhance patient care andfacilitate basic and translational research.

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TABLE OF CONTENTS Volume 8, Number 1, January 2021 Neurology.org/NN

Editor’s Corner

e925 N2 Year in ReviewJ. Dalmau, M.C. Dalakas, D.L. Kolson, F. Paul, and S.S. Zamvil

Open Access

Editorial

e932 Obesity’s Role in MS: An Intervention Target WithPossible InteractionsK. C. Fitzgerald, and E. M. Mowry

Open Access

Articles

e906 Chitinase 3–Like 1 and Neurofilament Light Chain inCSF and CNS Atrophy in MSR. Schneider, B. Bellenberg, B. Gisevius, S. Hirschberg,R. Sankowski, M. Prinz, R. Gold, C. Lukas, and A. Haghikia

Open Access Class of Evidence

e904 Mild Progressive Multifocal LeukoencephalopathyAfter Switching FromNatalizumab to OcrelizumabA.A. Toorop, Z.Y.G. van Lierop, E.E.M. Strijbis, C.E. Teunissen,A. Petzold, M.P. Wattjes, F. Barkhof, B.A. de Jong,Z.L.E. van Kempen, and J. Killestein

Open Access

e907 Clostridium Bolteae Is Elevated in NeuromyelitisOptica Spectrum Disorder in India and SharesSequence Similarity With AQP4L. Pandit, L.M. Cox, C. Malli, A. D’Cunha, T. Rooney, H. Lokhande,V. Willocq, S. Saxena, and T. Chitnis

Open Access

e908 Laquinimod Dampens IL-1β Signaling andTh17-Polarizing Capacity ofMonocytes in PatientsWith MSS. Engel, V. Jolivel, S.H.-P. Kraus,M. Zayoud, K. Rosenfeld, H. Tumani,R. Furlan, F.C. Kurschus, A. Waisman, and F. Luessi

Open Access

e913 Anti-CD20 Therapies and Pregnancy inNeuroimmunologic DisordersT. Kumpfel, S. Thiel, I. Meinl, A.I. Ciplea, A. Bayas, F. Hoffmann,U. Hofstadt-van Oy, M. Hoshi, J. Kluge, M. Ringelstein, O. Aktas,M. Stoppe, A. Walter, M.S. Weber, I. Ayzenberg, and K. Hellwig

Open Access

e915 Placental Transfer of NMDAR Antibodies CausesReversible Alterations in MiceA. Garcıa-Serra, M. Radosevic, A. Pupak, V. Brito, J. Rıos, E. Aguilar,E. Maudes, H. Ariño,M. Spatola, F. Mannara,M. Pedreño, B. Joubert,S. Gines, J. Planaguma, and J. Dalmau

Open Access

e916 Seizure-related 6 Homolog Like 2 Autoimmunity:Neurologic Syndrome and Antibody EffectsJ. Landa, M. Guasp, M. Petit-Pedrol, E. Martınez-Hernandez,J. Planaguma, A. Saiz, R. Ruiz-Garcıa, L. Garcıa-Fernandez,J. Verschuuren, R. Saunders-Pullman, L. Ramirez-Gomez,M.D. Geschwind, J. Dalmau, L. Sabater, and F. Graus

Open Access

e917 Eastern Equine Encephalitis and Use of IVImmunoglobulin Therapy and High-DoseSteroidsD.R. Wilcox, S.I. Collens, I.H. Solomon, F.J. Mateen, and S.S. Mukerji

Open Access

e911 Time Course of Dementia Following Sepsis inGerman Health Claims DataT. Fritze, G. Doblhammer, C.N. Widmann, andM.T. Heneka

Open Access

e920 Mendelian Randomization Study Shows No CausalEffects of Serum Urate Levels on the Risk of MSA. Harroud, J.B. Richards, and S.E. Baranzini

Open Access

e924 Overlapping Central and Peripheral NervousSystem Syndromes in MOG Antibody–associatedDisordersS. Rinaldi, A. Davies, J. Fehmi, H.N. Beadnall, J. Wang, T.A. Hardy,M.H. Barnett, S.A. Broadley, P. Waters, S.W. Reddel, S.R. Irani,F. Brilot, R.C. Dale, and S. Ramanathan,the Australian and New Zealand MOG Study Group

Open Access

Cover ImageIntrauterine exposure to patients’ IgG causes a transient increase ofdendritic complexity and decrease of spine density. Representativeimages by confocal microscopy of a DiI-stained CA1 hippocampalpyramidal neuron, and a secondary apical dendrite, with morphologicallyclassified dendritic spines. Stylized by Madeleine Sendek, MPH, DigitalMarketing Communications Coordinator.See page e915

Continued

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e926 High Serum Neurofilament Associates With DiffuseWhite Matter Damage in MSM. Saraste, S. Bezukladova, M. Matilainen, J. Tuisku, E. Rissanen,M. Sucksdorff, S. Laaksonen, A. Vuorimaa, J. Kuhle, D. Leppert, andL. Airas

Open Access

e928 Mesenchymal Stem Cell-Derived Neural ProgenitorsinProgressiveMS:Two-YearFollow-UpofaPhaseIStudyV.K. Harris, J.W. Stark, S. Yang, S. Zanker, J. Tuddenham, andS.A. Sadiq

Open Access

e931 Interleukin-15 Enhances Proinflammatory T-CellResponses in Patients With MS and EAEC. Laurent, G. Deblois, M.-L. Cleenet, A. C. Moratalla, N. Farzam-kia,M. Girard, P. Duquette, A. Prat, C. Larochelle, and N. Arbour

Open Access

e912 Overweight/Obesity in Young Adulthood InteractsWith Aspects of EBV Infection in MS EtiologyA. Karin Hedstrom, N. Brenner, J. Butt, J. Hillert, T. Waterboer,T. Olsson, and L. Alfredsson

Open Access Editorial, p. e932

Clinical/Scientific Notes

e905 LGI1 Encephalitis With Squamous Lung-CellCarcinoma: Resolution After Tumor ResectionA. Virupakshaiah, M.C. Dalakas, N. Desai, S. Mintzer, and J. Ratliff

Open Access

e910 A Case of Neonatal Onset Multisystem InflammatoryDisease Supporting a Role of Interleukin-1β inMoyamoya SyndromeF. Wohlrab, C. Bauknecht, C. Meisel, and J.P. Dreier

Open Access

e922 Tumefactive Inflammatory Lesions in JuvenileMetachromatic LeukodystrophyK. Meier, J. Gartner, and P. Huppke

Open Access

e927 Combination of Teriflunomide and Interferon asFollow-UpTherapyAfter Fingolimod-Associated PMLB. Fischer-Barnicol, J. Oechtering, J. Kuhle, J. Lorscheider,L. Kappos, and T. Derfuss

Open Access

Views & Reviews

e909 Intermediate Uveitis Associated With MS: Diagnosis,Clinical Features, Pathogenic Mechanisms, andRecommendations for ManagementA. Abraham, L. Nicholson, A. Dick, C. Rice, and D. Atan

Open Access

e914 IsMSAffecting theCNSOnly? Lessons FromClinic toMyelin PathophysiologyE. Oudejans, A. Luchicchi, E.M.M. Strijbis, J.J.G. Geurts, andA.-M. van Dam

Open Access

e918 Targeting B Cells to Modify MS, NMOSD, andMOGAD: Part 1J. Graf, J. Mares, M. Barnett, O. Aktas, P. Albrecht, S.S. Zamvil, andH.-P. Hartung

Open Access

e919 Targeting B cells to Modify MS, NMOSD, andMOGAD: Part 2J. Graf, J. Mares, M. Barnett, O. Aktas, P. Albrecht, S.S. Zamvil, andH.-P. Hartung

Open Access

e921 Chitinases and Chitinase-Like Proteins as Biomarkersin Neurologic DisordersR. Pinteac, X. Montalban, and M. Comabella

Open Access

e923 Presentations and Mechanisms of CNS DisordersRelated to COVID-19M. Bodro, Y. Compta, and R. Sanchez-Valle

Open Access

Diagnostic and Treatment Challenges

e929 Treating MS After Surviving PML: DiscreteStrategies For Rescue, Remission, andRecovery Patient 1: From the NationalMultiple Sclerosis Society Case ConferenceProceedingsN. Anadani, M. Hyland, R. Alejandro Cruz, R. Lisak, K. Costello,E.O. Major, Y. Jassam, E. Meltzer, T.C. Varkey, M.S. Parsons,A.D. Goodman, J.S. Graves, S. Newsome, S.S. Zamvil, E.M. Frohman,and T.C. Frohman

Open Access

e930 Treating MS After Surviving PML: DiscreteStrategies for Rescue, Remission, andRecovery Patient 2: From the NationalMultiple Sclerosis Society Case ConferenceProceedingsR. Alejandro Cruz, N. Hogan, J. Sconzert, M. Sconzert, E.O. Major,R.P. Lisak, E. Melamed, T.C. Varkey, E. Meltzer, A. Goodman,O. Komogortsev, M.S. Parsons, K. Costello, J.S. Graves, S. Newsome,S.S. Zamvil, E.M. Frohman, and T.C. Frohman

Open Access

Correction

e934 Monitoring of Radiologic Disease Activity by SerumNeurofilaments in MS

Open Access

e938 Identification of Circulating MOG-Specific B Cells inPatients With MOG Antibodies

Open Access

e949 Acute Disseminated Encephalomyelitis AfterSARS-CoV-2 Infection

Open Access

TABLE OF CONTENTS Volume 8, Number 1, January 2021 Neurology.org/NN

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2021;8; Neurol Neuroimmunol Neuroinflamm 8 (1)

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is an official journal of the American Academy of Neurology. Published since AprilNeurol Neuroimmunol Neuroinflamm