Dear Friends,For the past 60 years we have proudly worked towards fulfilling the vision of our founder, Dr. William Hutchinson, to improve human health through medical research.Over the past six decades, PNRI’s researchers have pioneered scientific advances that led to improvements in open heart surgery, early detection of prostate

cancer, and the identification of genetic predispositions to diabetes in newborns, to name just a few. In the past year alone, our scientists have applied their expertise in a variety of areas including liver disease, personalized cancer treatments, and anti-fungal therapies. During 2016, we also saw success in helping promising companies get off to a good start though our Urban Innovation Center, as Glyostasis’ Smart Insulin technology was acquired by Eli Lilly & Co., and FenoLogica Biosciences, Inc. was founded based on discoveries in the Dudley lab.As we look to the future, we will continue to pursue new opportunities to apply our innovative approaches to address complex biological questions. We look forward to our continued success in scientific discovery for the next 60 years and beyond.Best wishes,John R. Wecker, Ph.D.PRESIDENT & CEO PACIFIC NORTHWEST RESEARCH INSTITUTE

Welcome to PNRI’s 2016 Annual Report

Pacific Northwest Research Institute I 2016 I Annual Report to the Community

Postdoctoral fellowship for Dr. Jesse Riordan

Patients suffering from liver disease acquired an outstanding ally this year when PNRI’s Dr. Jesse Riordan received a prestigious Ruth L. Kirschstein National Research Service Award from the National Institutes of Health. The award enables Dr. Riordan to investigate the mechanisms of the most common form of liver disease, Non-Alcoholic Fatty Liver Disease. He will explore the effects of a high fat diet on mice and seek to understand why some appear to be completely protected from the disease —an unexpected result that is challenging our current understanding.

The proprietary method for Big Data analysis developed by PNRI’s Dr. David Galas continues to draw international interest and collabor-ative opportunities. In 2016, Dr. Galas joined forces with the German research company Indivumed GmbH to scrutinize their enormous collection of biological data from cancer patients. The “extremely innovative analytical platform” will reveal connections between a patient’s biology and the complexity of cancer, leading re-searchers closer to the development of effective personalized cancer treatments.

Dr. Aimée Dudley is admired for taking unconventional approaches that often lead to unexpected discoveries. Her lab has been collecting wild yeasts for studies on metabolic diseases. Regular lab yeast grows in smooth, round colonies, while many wild yeasts form intricate, complex colonies that scientists describe as “fluffy.” The “fluffy” appearance is associated with drug-resistant fungal infections and contaminated medical equipment. The Dudley team has discovered chemicals that disrupt “fluffy,” path-ogenic fungi. This research opened new avenues of inquiry into drug therapies for human fungal infec-tions, treatments for white-nose syndrome in bats, and the develop-ment of safer medical devices.

OPERATING REVENUE 2016Grants and contracts from federal and $ 4,516,829 44% governmental agencies Private grants $ 2,192,906 22%Contributions $ 2,038,856 20%Investment Income $ 958,171 9%Other revenue $ 486,130 5%Total Revenue $ 10,192,892 100%

Fiscal Year from October 1 to September 30

BALANCE SHEET 2016 2015Total Assets $ 23,059,720 $ 22,209,328Total Liabilities $ 1,399,973 $ 1,614,346Net Assets $ 21,659,747 $ 20,594,982

Collaborative partnership promises cancer insights

Anomaly opens new avenues of research

FINANCIALS

With gratitude to our donors who share our pride and enthusiasm in sustaining an outstanding research program. Gifts made in fiscal year 2016 from October 1, 2015 to September 30, 2016.

LIFETIME PLATINUM LAUREATESLifetime Giving of $1,000,000 or moreAnonymous-2Clairmont & Evelyn Egtvedt Charitable TrustHugh McCall TrustThe Josephine Stedem Scripps FoundationWilliam R. KlaischeByron & Alice Lockwood FoundationEduard O. Schreiner and Helen E. SchreinerIngrid SmithArthur C. and Ellen A. Waters

LIFETIME LAUREATESLifetime Giving of $500,000- $999,999Donald A. and Gladys F. Meyer

LIFETIME BENEFACTORSLifetime Giving of $100,000- $499,999Anonymous-4Gene AnthonyThe Biomembrane InstituteNorman Davis TrustMunro and Eleanor DennisJack and Matilda Dow FoundationKarl H. and Ruth S. EllerbeckOlive W. GlossopFrances C. HunterJohn P. Hussman, Ph.D.Malone O. and Kathleen L. HutchinsArdythe*and Ray JohnsonLucy H Zavadil Henry TrustStephan R. Martinez* and Kortney A. SaupeDouglas H. and Daryl McCallVirginia W. McConkeyMcKinstry Company Charitable FoundationM.J. Murdock Charitable TrustQuest for Truth FoundationRaymond and Vivian RenshawThe Scheetz FamilyGilliat* and Sherrill SchroederThe Seattle FoundationSilas A. Brainard TrustArnold N. and Hilda G. SmailesAmigo and Mildred SorianoSwedish Medical CenterTrysk Print Solutions

LIFETIME INNOVATORSLifetime Giving of $50,000-$99,999Anonymous-3Karl* and Anne AschenbachRobert* and Claire BrineMonte E. BrownJuanita Garrison* and Henry HoltCassius E.* and Rosella GatesCyrus K. Gates EstateCynthia Haba* and Joost van Haaren Carol* and Bill HeimkesClaude K. and Jennie B. KoetjeHarry D. LawsonRichard J. Omata* and Carol MoodyQuality Food CentersR. Paul** and Peggy RobertsonHelen Seaborn Trust

DISCOVERY SOCIETYDonors remembering PNRI in their wills, trusts, and estate plansAnonymous - 4Donald and Jane AbelMrs. Susan A. AdamsRobert M. ArnoldSilas A. Brainard TrustMonte E. BrownJane B. ClappNorman Davis TrustMunro and Eleanor Dennis

Jack and Matilda Dow FoundationClairmont & Evelyn Egtvedt Charitable TrustKarl H. and Ruth S. EllerbeckVirginia G. Eshelman TrustCassius E. and Rosella GatesCyrus K. Gates EstateOlive W. GlossopFrances C. HunterMalone O. and Kathleen L. HutchinsMary Jane L. JonesWilliam R. KlaischeClaude K. and Jennie B. KoetjeHarry D. LawsonHugh McCall TrustDouglas H.and Daryl McCallVirginia W. McConkeyHelen McCueKaren McGarrigle ReedDonald A. and Gladys F. MeyerMary Nuckols Evelyn M. PlantBernadine W. PleisArthur and Betty J. ReichertLouis W. SackettKirk SalvatoreEduard O. Schreiner and Helen E. SchreinerGilliat* and Sherrill SchroederArnold N. and Hilda G. SmailesIngrid SmithThe Josephine Stedem Scripps FoundationMargaret M. SwansonArthur C. and Ellen A. WatersRobert M. Winslow and Diane M. WinslowLucy H. Zavadil Henry Trust

ANNUAL DONORSLAUREATESGifts of $1,000,000 +Anonymous

INNOVATORSGifts of $50,000-$99,999Clairmont & Evelyn Egtvedt Charitable Trust

PIONEERSGifts of $10,000- $49,999Gene AnthonyMike Boyle*Stephan R. Martinez* and Kortney A. SaupeZak Martinkosky and Stefanie HarrisMicrosoft Corporation (Matching)The Scheetz FamilySwedish Medical CenterTrysk Print Solutions

INVESTIGATORSGifts of $5,000-$9,999Odin and Evie AndersonJoel and Sandy AslanianLinda Breneman and Eric StrandJuanita Garrison* and Henry HoltCynthia L. Haba* and Joost van HaarenKeyBank FoundationDerek Rothgeb and Ghost Star MorganR. Paul** and Peggy Robertson

EXPLORERSGifts of $1,000- $4,999Anonymous-2Alliant Employee BenefitsAdrian and Lindsay BagleyJeff and Carol Sue BarkerWilliam Barnard and Elizabeth

Corbett-BarnardJack BennettoChris and Brandy BoedigheimerAndrew and Brenda Bor

Bill and Ann BurstinerJames Cartales and Shannon PitschBill CrosettoDamien DreisDavid and Deena EasternStephanie EdwardsMark and Meredith England-MarkunEnwaveKen and Catherine* FisherNorma Fuentes** and Gary KirkMatthew and Alayna GagnierTom and Tina GrohmanAllison* and Jim HandyThomas* and Sara HaywardWarren and Kathryn HeylmanMark and Meghan HoganTyler and Senta HowrenGretchen S. HullIlluminaErik* and Jennifer IversonLen and Linda JohnsonKeyBankKibble & PrenticeK&L Gates LLPKnobbe MartensLee & Hayes, PLLCLincoln Financial GroupJudy Lytle** and Shamyl ZakariyaAnn* and David MartinCharles and Linda* MauzyMark and Kimberly McAlpinSusan* and Glenn McConnellMargaret McCormick*Marjorie McDonaldJohn Mulligan** and Philippa WebsterRebecca NelsonNintendo of AmericaEd NoonanKen and Pearl NoreenThe Norton FamilyScott and Jennifer OxleyRachel and Robert PerlmutterKeenan PiperJoe* and Lisa PiperBrian and Lacey PuhlRegence BlueShieldStanley and Lori RiddellKerry ShielsCynthia StroumThe Stroum Family FoundationJohn** and Margaret WeckerJolene WellerRachal Winger

VISIONARIESGifts of $500-$999Gary and Mary BaldridgeColby and Erin CavinRobb DaleLorraine del Prado and Thomas DonohueTom ElliottVaughan and Shannon EllmersBryon** and Carrina EppLeslie J. Garrison and Rodolfo FierroJoe FugereRobert and Janice GerthScott Haggerty and Elizabeth

Warren HaggertySusan and Steve HillDonald and Cathy HofferberRobert and Lynn* KernSean** and Rebecca MacLeodHeather McDonaldJoe** and Diane NadeauPaul Neal

James Papageorge and Rebecca** BruhnGareth Roe and Amy BruhnMario Shaunette and Gail E. MautnerDan and Anne SullivanJohn WeissJon Gores and Janet WelcherMark and Robin WhippleHerje and Carolyn Wikegard

INQUIRERSGifts of $100- $499AnonymousAmazonSmilesHeidi AndersonJulie** and Taylor AndersonElizabeth AylwardMary BargaDon and Tracie BrownNatalia BrownChad Carstens and LeiAnn ImbienBig John and Kimberly CaudillPaul and Laurie ClarkMark and Susan ClippingerDavid and Daniela ColterMark DavisTyson and Stephanie DickmanJeff and Terri DrayerAnn EidsonCynthia EllisRenske ErionVicki FabreFidelity Charitable Gift FundPhelps and Christel FisherDavid Forrester and Aimée Dudley**Patricia GaillardRick Gersbach and Elizabeth BreakstoneglassybabyJanine GreenJames GowinWilliam Hagopian**and Karen BensonSen-itiroh** and Mitsuko HakomoriCarol* and Bill HeimkesBarbara HerseyTyler HillThomas and Cheryl HobanJohn and Bonnie HutchinsonJim JacksonMary Jane JonesDave and Andrea KearnsKevin and Hannah KellyJean-Marie KentKing County Employee Giving ProgramKaaren KirkpatrickGary Kocher and Kristy HarlanDennis KroftDuane and Kelly LeonardGregg LewisBrandon LooMichael and Diana LudwigThomas MacBriarBrent MalesichCharlie and Heather MorrissMichael and Susie MurphyAndrew OverElizabeth PapageorgeChristopher Patano and Emily TrittschuhDave Patneaude and Ashley BushDavid and Jane PekaskySteve and Sue PetipasNicholas Peyton and Alexandra AdameRoland PlymillTy and Sally PollardCarol Postell

Continued

Please consider including PNRI in your

estate plans.

720 Broadway Seattle, WA 98122

(206) 726-1200 (800) 745-1527 www.pnri.org

For more information, contact:

Norma Fuentes Chief Development Officer

nfuentes@pnri.org (206) 568-1459

Elizabeth RaetzMike RalphNorman J. Reed and

Karen J. McGarrigle ReedAaron and Leah ReganBrendan RevilleRandy and Christina RiffleSarah RivardMelanie RobertsKeith RosemaSam and Ivy RosenthalDeb SabottaThe Seattle FoundationBrian and Andrea SeitzJoseph Simmons and Gina Barone SimmonsElaine Skeffington**Dan and Renee SommerStokes Auction Group, Inc.Steve and Jeanette StrandJulie TobiassenUBS Financial Services Inc.Jordon and Stephanie ValenteBanks* and Valerie WardenWashington State Combined Fund DriveJohn WatsonGreg WilliamsPaul and Dori YangMohamed and Sally Zakariya

IN KIND GIFTSGifts valued at $100 +Gene AnthonyACTRobert and Pauline BachBarone CrystalBelltown BrideButler Wine Tours

Big John and Kimberly CaudillChateau Ste. MichelleCorks And Canvas EventsCorliss EstatesCote BonnevilleCourtyard by Mariott Walla WAllaDunham CellarsRichard DuvalEl Gaucho HospitalityMark and Meredith England-MarkunExperience Music ProjectGarageCynthia L. Haba* and Joost van HaarenSherry HabaHey Jude CateringSteve and Susan HillHotel SorrentoJohn Howie RestaurantsJubilee Event EngineersRichard and Sharon MaliaStephan R. Martinez* and Kortney A. SaupeMark and Kimberly McAlpinElaine and David MeachamPacific Science CenterSony Playstation Reininger WineryRobert Ramsay CellarsSasha Reiko PhotographySass WinerySeattle MetSeattle Repertory TheatreSheraton Seattle Hotel & TowersSheridan VineyardSpace Needle LLCSugar MountainTranche

Va Piano VineyardsVito’sWalla Faces InnThe Weinhard Hotel

TRIBUTE GIFTSIN HONORGeorgina Bayley: gift in honor of

Ian and Mathew McNivenDavid and Cheryll Blair: gift in honor

of Marla Kay MorrowBill and Ann Burstiner: gift in honor

of Ruth BurstinerDonald and Cathy Hofferber: gift in honor

of Stephan R. MartinezMichael and Sara Matarese: gift in honor

of David and Ann MartinMichael and Sara Matarese: gift in honor

of David Martin’s BirthdayMichael and Sara Matarese: gift in honor

of Ann Martin’s BirthdayEvan Johnson: gift in honor of the

Kern FamilySusan and Duane Locknane: gift in honor

of Carol HeimkesHeather McDonald: gift in honor

of David, Ann and Michael MartinMarjorie McDonald: gift in honor

of Ann and Mike MartinRonald and Patricia Nelson: gift in honor

of Danielle Whipple and Michael NelsonRachel and Robert Perlmutter: gift in

honor of Elliot PerlmutterDavid and Barbara Schmedding:

gift in honor of Daniel Schmedding and Jennifer Kelson

Chris Taylor: gift in honor of Debbie Foell’s Birthday

IN MEMORYGerald and Virginia Anderson:

gift in memory of Dick NaubertAndrew Chanez: gift in memory of

Corazon PizarroBill Crosetto: gift in memory of

Dr. William Hutchinson, Sr.Vicki Fabre: gift in memory of

Ross GilesHelen Hagopian: gifts in memory of

Arthur HagopianHelen Hagopian: gift in memory of

Regina SommerHelen Hagopian: gift in memory of

Cecelia MelloCarol and Bill Heimkes: gift in memory

of Robert GallagherGregg Lewis: gift in memory of Dylan TrippAlex Pizarro: gift in memory of

Corazon PizarroThe Scheetz Family: gift in memory of

Elizabeth M. Scheetz* Indicates former or current PNRI Trustee** Indicates PNRI Staff