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Weight Management Clinic
Program Orientation
Amy Rothberg, MD, PhD, Andrew Kraftson, MD, Charles Burant, MD, PhD Christine Fowler, RD, MS and Gina Neshewat, MPH
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This is the UM Weight Management Clinic Schedule of Visits.
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The visits are more frequent during the first 3 months of the program. Thereafter, the visits to the physician are quarterly (every 12 weeks) and monthly to the dietician.
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Research Program Component
• There are research programs offered by UM
• These programs are separate from the clinical program, but can be helpful to add important information to help you manage your health
• Participation is voluntary
The Scope of Obesity
Obesity Rates: United States
Where is obesity most common in the US?
Obesity Rates: United States
Obesity is especially common in the South. It has 10 out of the 11 states with the highest obesity rates, including Mississippi along with Alabama and Tennessee, which tied for second place.
Obesity Rates: United States
Michigan is the only state in the top 11 that is not in the South.
The prevalence of overweight and obesity changed little between the early 1960s and 1980. Findings from the 1988-1994 and 1999-2004 National Health and Nutrition Examination Surveys, showed substantial increases in overweight among adults.
The upward trend in weight since 1980 reflects primarily an increase in the percentage of adults 20-74 years of age who are obese. In 2003-2004, 67% of adults in that age group were overweight (includes obese); 34% of adults 20-74 years of age were obese (age-adjusted).
Since 1960-1962, the percentage of adults who were overweight but not obese has remained steady at 32%-34% (age-adjusted). Criteria for overweight: BMI value of 27.8 or greater for men and 27.3 or greater for women. Criteria for obese is BMI greater than 30.
Energy Homeostasis
Energy Intake
Ingestion of:
Protein
Fat
Carbohydrate
Energy Expenditure
Physical Activity
Diet-Induced Thermogenesis
Basal Metabolic Rate
Body Weight
Increase Decrease
Body weight is determined by the balance between the calories we consume and the calories we expend (aka: “burn”).
Atherosclerosis
Hypercoagulability
CVDOver-Nutrition
PrimaryMetabolic
Disturbance
Intermediate Vascular Disease
Risk Factor Intravascular
PathologyClinicalEvent
Hypertension
Dyslipidemia
Hyperinsulinemia
Hyperglycemia
Inflammation
ImpairedFibrinolysis
Endothelial Dysfunction
• Coronary arteries• Carotid arteries• Cerebral arteries• Aorta• Peripheral arteries
Insulin Resistance
Modified from Despres JP, Lemieux I. Nature. 2006;444:881-7.
Overnutrition, Type 2 Diabetes and CVD
What are the consequences of too much weight? Overnutrition leads to a number of metabolic problems that lead to diseases such as diabetes and heart disease.
Growth in Caloric and CHO Intake
MMWR. 2005;53:80-82.
There has been a substantial growth in our intake with greater intake of carbohydrates. Between 1974 and 2000, men have increased their caloric consumption by 7% and women by as much as 22%.
Growth in Caloric and CHO IntakeCaloric Intake (kcal/day)
MMWR. 2005;53:80-82.
Years 1971 – 1974 1999 – 2000 Change
Men 2450 2618 (+) 168
Women 1542 1877 (+) 335
There has been a substantial growth in our intake with greater intake of carbohydrates. Between 1974 and 2000, men have increased their caloric consumption by 7% and women by as much as 22%.
Growth in Vehicle Miles TraveledGrowth in “Overweight”
Source: National Household Travel Survey.
(50% Overall Growth) (40% Overall Growth)
Growth Trend for Annual Household Vehicle Miles of Travel (VMT)
Growth Trend for Percentage of Americans “Overweight”
30
35
40
45
50
55
60
65
70
1969 1977 1983 1990 1995 2001
BMI >30 kg/m2
8000
10000
12000
14000
16000
18000
20000
1969 1977 1983 1990 1995 2001
VMT
These charts illustrate the parallel trend between growth in Vehicle Miles of Travel and the growth in the percent of overweight Americans. The majority of health problems associated with behavioral change caused by the built environment are, unfortunately, more extreme; they include obesity, early onset diabetes, heart failure, respiratory failure, and some forms of cancer.
But Other Things Are Changing as Well…
Keith SW, et al. Int J Obes. 2006;30:1585-1594.
But Other Things Are Changing as Well…
Keith SW, et al. Int J Obes. 2006;30:1585-1594.
Other factors in our environment have contributed to this rise in overweight/obesity. The light blue line is the Adult Obesity prevalence which has been rising, but steeply increased at the end of the 1970s.
But Other Things Are Changing as Well…
Keith SW, et al. Int J Obes. 2006;30:1585-1594.
In parallel with that climb was the average rise in our home temperature setting (yellow), the number of prescriptions written in the millions for antidepressants (pink), and time spent awake (time at jobs) (green).
• Genes• Environmental setting• Experience
Short term regulation of feeding
Food intake is a complex process. The amount and type of food ingested is determined by:
Short term regulation of feeding
Short term regulation of feeding is governed by:
• Taste perception• Meal size, caloric density• Environmental setting• Signals emanating from
GI system and energy stores are received and integrated by diverse neuronal circuits in the hypothalamus and brainstem.
“Caloric density” as a concept
Fresh corn
490
Tortillas Tortilla chips
Think of foods in terms of calories per pound
2450
1000
“Caloric density” as a concept
Think of foods in terms of calories per pound
490
2450
1000
The volume of food consumed and its energy density affect intake through differential stimulation of gastric and post-gastric compartments. The stomach is sensitive to cues related to volume and that manipulation of gastric distension affects food intake.
“Caloric density” as a concept
Think of foods in terms of calories per pound
490
2450
1000
The lower in caloric density, the greater the volume and the fewer the number of calories. Fresh corn has far fewer calories than a similar serving size of tortillas (made from corn) and Tostito’s® (a product of corn).
Gut Peptides - Satiety Signals
Mountjoy, Kyiv 2003
Our sense of hunger and fullness are determined by complex interactions between a number of peptides (proteins) and hormones (such as leptin, PYY, CCK, ghrelin, and insulin) that relay signals from our gut to our brain . We are studying these signals and processes.
As you may know, our eating patterns are affected by more than the caloric and nutritional value of food. The emotional and pleasurable aspects of feeding affect food intake.
It will come as no surprise, then, that the brain (particularly parts of the brain called the hypothalamus and the brainstem) has a central role in coordinating the many nutrient, hormonal, and behavioral signals to regulate food intake, metabolism, and ultimately body weight.
These central circuits and neuro-peptides have a pivotal role in triggering hunger and food search, initiating satiety and generating responses to peripheral adiposity (fat) signals.
There are additional brain/central nervous system regions that participate in regulating appetitive behavior by mediating themotivational, cognitive, and emotional components of food intake. Gaining a better understanding of the brain’s role in weight is one of our goals.
Randomized, Clinical Trials to Prevent Diabetes by Lifestyle Modification
The UM Weight Management Clinic program has modeled itself after large epidemiological trials of lifestyle intervention. We have summarized data from some of these studies:
Randomized, Clinical Trials to Prevent Diabetes by Lifestyle Modification
Nature Clinical Practice 2008; 4:382-393
Study* # Patients Baseline BMI (kg/m2)
Duration of intervention (years)
Lifestyle goals
Weight loss at 1 year (kg)
Risk Reduction (95% CI)
DaQing Study (1997) 530 26 6
Weight loss + maintenance of a health diet + exercise
NR 42%
Finnish Diabetes Prevention Study (2001)
522 31 4
5% weight loss on low-fat, high-fiber diet + 30 min exercise per day
4 58%
Diabetes Prevention Program (2002)
2161 34 37% weight loss + 150 min exercise per week
7 58%
*All study populations had impaired glucose tolerance
Randomized, Clinical Trials to Prevent Diabetes by Lifestyle Modification
Nature Clinical Practice 2008; 4:382-393
Study* # Patients Baseline BMI (kg/m2)
Duration of intervention (years)
Lifestyle goals
Weight loss at 1 year (kg)
Risk Reduction (95% CI)
DaQing Study (1997) 530 26 6
Weight loss + maintenance of a health diet + exercise
NR 42%
Finnish Diabetes Prevention Study (2001)
522 31 4
5% weight loss on low-fat, high-fiber diet + 30 min exercise per day
4 58%
Diabetes Prevention Program (2002)
2161 34 37% weight loss + 150 min exercise per week
7 58%
*All study populations had impaired glucose tolerance
These two trials split a large group of individuals at high risk for diabetes into two groups: 1. usual care2. intensive lifestyle intervention = eating a low calorie diet of 1,500 calories per day and
exercising 150 minutes per week.
Randomized, Clinical Trials to Prevent Diabetes by Lifestyle Modification
Nature Clinical Practice 2008; 4:382-393
Study* # Patients Baseline BMI (kg/m2)
Duration of intervention (years)
Lifestyle goals
Weight loss at 1 year (kg)
Risk Reduction (95% CI)
DaQing Study (1997) 530 26 6
Weight loss + maintenance of a health diet + exercise
NR 42%
Finnish Diabetes Prevention Study (2001)
522 31 4
5% weight loss on low-fat, high-fiber diet + 30 min exercise per day
4 58%
Diabetes Prevention Program (2002)
2161 34 37% weight loss + 150 min exercise per week
7 58%
*All study populations had impaired glucose tolerance
Those that achieved a 5-7% weight loss from baseline weight reduced their risk of progression to diabetes by 58%. This is better than any study that used medications as the primary treatment.
Randomized, Clinical Trials to Prevent Diabetes by Lifestyle Modification
Nature Clinical Practice 2008; 4:382-393
Study* # Patients Baseline BMI (kg/m2)
Duration of intervention (years)
Lifestyle goals
Weight loss at 1 year (kg)
Risk Reduction (95% CI)
DaQing Study (1997) 530 26 6
Weight loss + maintenance of a health diet + exercise
NR 42%
Finnish Diabetes Prevention Study (2001)
522 31 4
5% weight loss on low-fat, high-fiber diet + 30 min exercise per day
4 58%
Diabetes Prevention Program (2002)
2161 34 37% weight loss + 150 min exercise per week
7 58%
*All study populations had impaired glucose tolerance
Lifestyle change continues to be reasonable, rational and feasible approach to weight management and risk reduction of chronic diseases.
Weight Management Clinic→Goal: Identify strategies that will result
in long-term weight management for obese individuals, using the latest research and clinical strategies.
→We are dedicated to educating, motivating, and empowering individuals to make healthy lifestyle choices!
Comprehensive Adult Weight Management Clinic
Personalized Weight Management Program• Multidisciplinary approach to weight loss and weight
maintenance• Intensive induction phase• Advice regarding activity/exercise/conditioning• Individual one-on-one sessions• Focus on prevention of weight regain
– Behavioral– Nutritional– Pharmacological
Stepped Obesity
Treatment Regimen
What happens at the first visit to the physician? • Your health and weight history is reviewed.• A physical exam is performed.• Your current medication list is examined.• The research is reviewed and your consent
to participate is obtained (if you are interested).
Change medication regimen
• Eliminate ‘weight positive’ medications
• Substitute weight neutral or weight negative medications1
Initiate caloric restriction
• Initial very-low-calorie diet (VLCD )(800 cals/day) or low-calorie-diet (LCD) (1000-1200 cals/day):
• Meal substitution/replacement
• Dietary counseling: One-on-one with RD
• Initial emphasis on calories and caloric density, not fuel
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The meal replacement diet will not start until you meet formally with the program’s dietician.
Exercise prescription
• Individual preference/Get moving
• Bouts of activity v. all at once 3
Research Component(“phenotyping”)
• Integral to the understanding of obesity • Examination of gene-gene interactions and gene-
environmental interactions- a systems biology approach• Identifying the factors that predict success for weight loss and
maintenance of weight loss – key to changing our treatment paradigms
• Examining potential novel therapeutic targets• Participation is VOLUNTARY
Procedures
Mixed Meal Tolerance Testing: 3 hour dynamic test examining hormone excursions (insulin, glucose, and fat hormones) in response to nutrients.
• Metabolomics is the analysis of metabolites performed to generate a specific fingerprint of a current metabolic state at any given time point. It allows characterization of the dynamic changes of the metabolic pattern of person in response to nutrients.
• Genetic Analysis identifying obesity and obesity-related genes
Oral Glucose Tolerance Test: 2 hour test to diagnose diabetes*.
Resting and exercise tests to determine your resting metabolic rate and exercise capacity/fit-ness
Questionnaires regarding overall health and impact of weight on emotional and physical well-being
*1/3rd of the participants in the program have undiagnosed Type 2 diabetes mellitus.
DXA-measures body composition including fat free mass, fat mass and bone density
Bod Pod-alternative method to measure fat free mass and fat mass
Resting Energy Expenditure-measures the fuel the body burns at rest (the number of calories burned at rest)
V02 max-Exercise capacity is highly predictive of disease risk, longevity and may predict the ability to lose weight. Graded exercise test done on a treadmill.
SenseWear Triaxial AccelerometerMovement/motion sensor Worn for 7 days at intervals:Baseline (prior to diet)5% weight loss from baseline10% weight loss from baseline15% weight loss from baseline6 months, 12 months and 24 months
Products for Medical Professionals
Re-Phenotyping:You will have the option to repeat the testing after the initial 15% weight loss goal is achieved.
Sweet Taste Study II
• Procedure– Questionnaire– Tasting sugar water at various concentrations– Medical record review and linkage to your research data– Compensation: $16 gift card for each research clinic visit– Location: Clinics at Domino’s Farms
• Contact – Keiko Asao, Phone 734-232-8270, E-mail
• Please find the information in your package. You can turn in the completed response sheet now or mail it.
Weight Maintenance by Sex
Baseline Week 2 Week 4 Week 8 Week 12 Week 18 Week 24 Week 28 Week 32 Week 36 Week 40 Week 44 Week 48 Week 52 Week 56 Week 6085
95
105
115
125
129
125
120
114
110
106105
104 104106 106
103 103 103 103 103
111
107
104
100
97
9492
9091
93 93
9092 92
93
90
Male Female
Number of Weeks in Program
Wei
ght (
kg)
The University of Michigan’s Weight Management Clinic
(WMC) Program:Overview
• Highly structured to make weight loss easier and more successful.
• Shakes and soups replace meals and snacks.
• Support provided through individual appointments with physician and dietitians.
• Daily physical activity aids in weight loss.
Program Design
12 weeks…
• Initial 12 weeks: 800 calories per day• Foods Allowed:
HMR 800 Shakes HMR 70+ Shakes if Lactose
Intolerant HMR Chicken Soup
Very Low Calorie Diet (VLCD) Phase
• Personalized for you
• Average prescription: 4 - 5 HMR Shakes + 1 HMR Chicken Soup
• Concept: “More is Better” but “Stay in the Box”
Meal Replacement Prescription
Why use a Very-Low Calorie Diet (VLCD)?• Short term only: initial 12 weeks • Medically supervised, guaranteed
weight loss • Divorce yourself from unhealthy food
habits by making meals “decision free”• Learn nutrition information, lifestyle and
behavioral skills
15
10
5
0
Time (mo)
Phase 2 Phase 1*
MR-2
0 2 4 6 8 10 12 18 24 30 36 45 51
MR-1
Perc
enta
ge W
eigh
t Los
s
CF
Meal Replacements Enhance Initial and Long-term Weight Loss
*1200–1500 kcal/d diet prescription.CF=conventional foods.MR-2=replacements for 2 meals, 2 snacks daily.MR-1=replacements for 1 meal, 1 snack daily.
.
Ditschuneit et al. Am J Clin Nutr 1999;69:198.Fletchner-Mors et al. Obes Res 2000;8:399
Why VLCD with HMR?
• HMR is a national healthcare company specializing in weight loss and weight management.
• HMR is a leading provider of meal replacement system in clinics and hospitals throughout the country.
• Following 15% weight loss, food is reintroduced.
• An individualized diet plan is designed and implemented.
• Maintenance calorie amount is calculated and personalized.
Weight Maintenance Phase
Can people with diabetes use HMR shakes?
• Yes. HMR is frequently recommended by doctors for their patients with diabetes because of the foods' nutritional formulation and low calories.
• Your medication(s) will be monitored by our physicians, and dosage may change throughout the program.
Can I use HMR shakes if I have food allergies?
• HMR products are generally well tolerated by most people. Some of our products, however, contain common allergens such as dairy, eggs, wheat, soy and peanuts.
• Please let us know if you have any allergies prior to beginning the shake regime, or if any GI discomfort occurs.
I’m lactose intolerant. Is there lactose in HMR?• Most of the HMR Shakes contain lactose. However, people who are lactose-intolerant can use HMR shakes by taking a Lactaid® tablet.
• -or- HMR 70 Plus shakes are lactose-free
+ or
Blender Instructions:1. Pour 6 oz. cold water into a blender.
Begin mixing on lowest speed.2. While blender is on, add 1 packet
HMR shake mix and blend for 10 seconds.
3. Add 2 ice cubes, 1 at a time (replace blender cover in between)
4. Continue to blend on low speed for 1 – 1 ½ mins. until ice is crushed & shake is smooth
Shake Preparation
Add non-caloric flavorings for variety:• Spices or seasonings• Extracts• Diet soda• Sugar free pudding or Jell-O mix• Sugar free Crystal light • Sugar free coffee syrup
Meal Replacement Prescription:
You are responsible for purchasing the product (~$2-3 per shake or ~$12/day.)
Costs of HMR:
Some easy ways to find HMR are:• Saint Joseph Mercy Health System:
Ellen Thompson Women’s Health Center 5320 Elliot Drive, Ypsilanti, MI 48197Phone: 734-712-5540Fax: 734-712-2722
• HMR program website: http://www.hmrprogram.com/ and follow instructions from “order online” link
Ordering HMR:
Physical Activity• Daily exercise is
tracked• Active lifestyle is
encouraged• Further
recommendations will be based on the individual
Questions or concerns?Please contact:
• Christine Fowler, RD: [email protected]• Gina Neshewat, MPH: [email protected]• Andrew Kraftson, MD: [email protected]• Amy Rothberg, MD, PhD: [email protected]
When sending an email, please “cc” everyone so the whole team is able to assist. Thank you!
Need to set up your first nutrition visit or reschedule? Please call: 734-647-5871
Thank you!
