VIROLOGY MCQ 1

8/10/2019 VIROLOGY MCQ 1

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1

Multiple Choice Questions - Paper 1

Instructions for candidates

The examination consists of 30 multiple choice questions, each divided into 5different parts. Each part contains a statement which could be true or false. Eachquestion will have at least one part which is true. For each part, you should indicatewhether you thin it is true !T", false !F", or don#t now !$%". &ou must fill in therelevant square with a blac pen. 'ne mar will be (iven for each correct answer andone mar deducted for each incorrect answer. &ou will not be mar ed for thosequestions for which you have indicated )don#t now).

1. Viruses

*ontain both $%+ and %+

-ay have an envelope

ave their own metabolism

-ay contain en/ymes for replication

*ell wall

2. The following are DN !iruses

erpesviruses

'rthomyxoviruses

Enteroviruses

epadnaviruses

arvoviruses

". The following are #N !iruses

icornaviruses

+denoviruses



2

apillomaviruses

habdoviruses

otaviruses

$. %i!e attenuated !accines are a!aila&le against the following !iruses

1nfluen/a + 2irus

epatitis 2irus

ubella 2irus

&ellow Fever 2irus

2aricella4 oster 2irus

'. The following anti!iral agents is acti!e against the following !irus

6amivudine and 12

6amivudine and 2

+mantidine and 1nfluen/a virus

ibavirin and 72

+cyclovir and 72

(. )erpes *i+ple, ncephalitis

*ommonly affect the temporal lobe

1s usually dia(nosed by culture of the *7F

-ay be dia(nosed by * of the *7F



3

7hould be treated with 12 (anciclovir

-ay be dia(nosed by the findin( of specific antibody in the *7F

. The following state+ents are true of Varicella-/oster Virus

*auses a maculopapular rash

espond to + T therapy

emains latent in sensory (an(lia followin( primary infection

ecurrent episodes of 7hin(les usually occur

atients with shin(les are not infectious

0. C to+egalo!irus CMV3

rimary infection is usually symptomatic

+n infectious mononucleosis4li e syndrome may occur durin( primary infection.

-ay cause severe infection in immunocompromised individuals

1s terato(enic

*auses 8awasa i9s $isease

4. pstein-5arr Virus 5V3 is associated with

1nfectious -ononucleosis

epatitis

ur itt9s lymphoma

%asopharyn(eal carcinoma

'ral leu opla ia

16. ))V-( is associated with



4

Fifth disease

oseala 1nfantum

8aposi9s 7arcoma

1nfectious -ononucleosis4li e illness

'ral leu opla ia

11. deno!iruses

+re associated with (enital cancers

-ay cause (astroenteritis

-ay cause con:unctivitis

-ay cause pneumonia

-ay cause warts

12. Papillo+a!iruses24; and 24<< are associated with (enital cancers

24<; and 24<= are associated with (enital cancers

>arts caused by papillomaviruses may respond to interferon therapy

apillomavirus infection is commonly dia(nosed by viral culture

+re associated with pro(ressive multifocal leucoencephalopathy ! -6"

1". Co,sac7ie 5 Virus is associated with the following

aralytic illness

-yocarditis



5

ornholm9s disease

7evere con(enital infection

-enin(itis

1$. Influen8a Virus

-ay under(o anti(enic shift and anti(enic drift

-ay cause pandemics

espond to rimantidine

espond to neuraminidase inhibitors

2accination confers lifelon( protection

1'. Para+ ,o!iruses +a cause

*roup

-aculopapular rash

neumonia

ronchiolitis

$iarrhoea

1(. #espirator * nc tial Virus #*V3

espond to +mantidine

-ay cause bronchiolitis

-ay cause croup

-ay cause pneumonia



6

-ay be prevented by vaccination

1 . Par!o!iruses

*auses oseola 1nfantum

*auses Erythema 1nfectiousum

1s terato(enic

-ay cause abortion

-ay cause aplastic crisis in persons with haemolytic anaemias

10. Measles Virus Infection

*auses a vesicular rash

-ay cause encephalitis

-ay respond to acyclovir

-ay be prevented by %1?

-ay be prevented by vaccination

14. #u&ella Virus

The rash of rubella is similar to that caused by parvo and enteroviruses

1s terato(enic

*on(enital rubella is charaterised by eye, ear and heart defects

*on(enital rubella is dia(nosed by the findin( of rubella4specific antibody in the cord blood of infants

1nfants with con(enital rubella poses a (reat infectious ris .

26. )u+an T-l +photropic !irus 1 )T%V-13 is associated with

ur itt9s lymphoma

+dult T4cell lymphoma



7

Tropical 7pastic araparesis

-ultiple 7clerosis

od( in9s lymphoma

21. )IV Infection +a lead to

$ementia

*hronic $iarrhoea

*-2 retinitis

'esopha(eal candidiasis

%on4 od( in9s lymphoma

22. The following +a &e useful for prognostic purposes in )IV-infected indi!iduals

12 envelope antibody124p@A anti(en

*$A count

12 pro4viral $%+ in leucocytes

12 plasma %+

2". chronic carrier state +a occur in the following9

antavirus 1nfection

epatitis +

epatitis

epatitis *



8

7mallpox 1nfection

2$. The following +ar7ers are usuall present in a hepatitis 5 carrier with chronic acti!e hepat

be+(

+nti4 c 1(?

+nti4 c 1(-

24$%+

bs+(

2'. The following state+ents are true

*hronic 2 infection may respond to interferon therapy

*hronic *2 infection may respond to interferon therapy

*hronic *2 infection may respond to ribavirin therapy

epatitis $elta infection may be prevented by vaccination a(ainst 2

epatitis E 1nfection may be prevented by vaccination

2(. The following !iruses can &e trans+itted & &lood

epatitis +

12

T624<

2

*2

2 . #egarding !iral infection of the central ner!ous s ste+ CN*3



9

-enin(itis may occur to(ether with encephalitis

Enteroviruses are one of the commonest causes of *%7 infections in childhood

72 encephalitis is a postinfectious encephalomyelitis

-easles encephalitis is a postinfectious encephalomyelitis

The detection of antibody in the *7F is a useful dia(nostic mar er

20. The following !iruses are associated with gastroenteritis

+stroviruses

%orwal 4li e viruses

*aliviruses

+denoviruses

otaviruses

24. The following !iruses are trans+itted fro+ ani+als to hu+ans

abies 2irus

olioviruses

*-2

antaviruses

6assa Fever 2irus

"6. The following is true of ra&ies !irus

The ma:ority of cases worldwide result from bat bites

1nfection may be prevented by active and passive immunisation

abies vaccine is a live attenuated vaccine

The animal reservoir differ from country to country

-ay be dia(nosed by serolo(y



10

nswers to Mulitple Choice Questions - Paper 1

1. Viruses

*ontain both $%+ and %+

-ay have an envelope



11

ave their own metabolism

-ay contain en/ymes for replication

*ell wall

2iruses contain either $%+ or %+ but not both. 7ome may have an envelope. Bnli e bacteria, they do not have a celltheir own metabolism. They may contain en/ymes for replication.

2. The following are DN !iruses

erpesviruses

'rthomyxoviruses

Enteroviruses

epadnaviruses

arvoviruses

erpesvirus and epadnaviruses are double stranded $%+ viruses. arvovirus is a sin(le stranded $%+ virus. 'rthomyxand enteroviruses are sin(les stranded %+ viruses.

". The following are #N !iruses

icornaviruses+denoviruses

apillomaviruses

habdoviruses

otaviruses

+denoviruses and papillomaviruses are double standed $%+ viruses. icornaviruses and rhabdoviruses are sin(le strandeviruses. otaviruses are double stranded %+ viruses.

$. %i!e attenuated !accines are a!aila&le against the following !iruses

1nfluen/a + 2irus

epatitis 2irus



12

ubella 2irus

&ellow Fever 2irus

2aricella4 oster 2irus

6ive attenuated vaccines are available a(ainst rubella, yellow fever, and varicella4/oster viruses. 1nfluen/a + viral vaccineither inactivated split or subunit vaccines. The vaccines in current use a(ainst hepatitis are recombinant subunit vaccin

'. The following anti!iral agents is acti!e against the following !irus

6amivudine and 12

6amivudine and 2

+mantidine and influen/a virus

ibavirin and 72

+cyclovir and 72

6amivudine is a reverse transcriptase inhibitor active a(ainst both 12 and 2. +mantidine is active a(ainst influen/aibavirin is active a(ainst 72 and acyclovir a(ainst 72

(. )erpes *i+ple, ncephalitis

True *ommonly affect the temporal lobe

False 1s usually dia(nosed by culture of the *7F

True -ay be dia(nosed by * of the *7F

False 7hould be treated with 12 (anciclovir

True -ay be dia(nosed by the findin( of specific antibody in the *7F

*omments erpes 7implex Encephalitis commonly affect the temporal lobe. *ulture of the *7F is usually uis a much better choice. + dia(nosis can also be made by the detection of 724specific antibodiesEncephalitis should be treated with 12 acyclovir.

. The following state+ents are true of Varicella-/oster Virus



13

False *auses a maculopapular rash

False espond to + T therapy

True emains latent in sensory (an(lia followin( primary infection

False ecurrent episodes of 7hin(les usually occur

False atients with shin(les are not infectious

*omments 2 2 causes a vesicular rash. 1t does not respond to + T as it does not possess reverse transcriptasensory (an(lia followin( primary infection. 1t is rare for more than one episode of shin(les to ocinfectious.

0. C to+egalo!irus CMV3

True rimary infection is usually symptomatic

True +n infectious mononucleosis4li e syndrome may occur durin( primary infection.

True -ay cause severe infection in immunocompromised individuals

False 1s terato(enic

False *auses 8awasa i9s $isease

*omments rimary *-2 infection is usually asymptomatic. 'ccasionally, an infectious mononucleosis4li e primary infection. *-2 is well nown to cause severe disease in immunocompromised individua

recipients and patients with +1$7. +lthou(h it may cause severe con(enital infection, it is not teraformed fetal or(ans. 1t is not associated with 8awas i9s disease.

4. pstein-5arr Virus 5V3 is associated with

True 1nfectious -ononucleosis

True epatitis

True ur itt9s lymphoma

True %asopharyn(eal carcinoma

True 'ral leu opla ia

*omments +ll the above



14

16. ))V-( is associated with

False Fifth disease !erythema infectiosum"

True oseala 1nfantum

False 8aposi9s 7arcoma

True 1nfectious -ononucleosis4li e illness

False 'ral leu opla ia

*omments arvovirus is associated with Fifth disease !erythema infectiosum". 24; is associated with 7ixt24= is associated with 8aposi9s sarcoma. arely, in adults, primary 24; infection may resul

mononucleosis4li e illness. E 2 is associated with oral leu opla ia

11. deno!iruses

False +re associated with (enital cancers

True -ay cause (astroenteritis

True -ay cause con:unctivitis

True -ay cause pneumoniaFalse -ay cause warts

*omments uman papillomaviruses are associated with (enital cancers. +denoviruses type A0 and A< are as+denoviruses may also cause con:unctivitis and pneumonia. uman papillomaviruses are associa

12. )u+an Papillo+a!iruses

False 24; and 24<< are associated with (enital cancers

True 24<; and 24<= are associated with (enital cancers

True >arts caused by papillomaviruses may respond to interferon therapy

False apillomavirus infection is commonly dia(nosed by viral culture

False +re associated with pro(ressive multifocal leucoencephalopathy ! -6"



15

*omments 24<; and 24<= are associated with (enital cancers. >arts caused by papillomaviruses mayalthou(h it is rarely used. uamn apillomaviruses cannot be (rown in cell culture. olyomavirus

1". Co,sac7ie 5 Virus is associated with the followingTrue aralytic illness

True -yocarditis

True ornholm9s disease

True 7evere con(enital infection

True -enin(itis


1$. Influen8a Virus

True -ay under(o anti(enic shift and anti(enic drift

True -ay cause pandemics

True espond to rimantidine

True espond to neuraminidase inhibitors

False 2accination confers lifelon( protection

*omments 1nfluen/a + 2irus may under(o anti(enic shift and anti(enic drift. +nti(enic shifts result in panderespond to rimantidine, which is a similar compound to amantidine. 1t will also respond to newlyinhibitors. ecause of constant anti(enic chan(es, vaccination will not confer lifelon( immunityD i

1'. Para+ ,o!iruses +a cause

True *roup

False -aculopapular rash

True neumonia

True ronchiolitis

False $iarrhoea



16

*omments aramyxoviruses most commonly cause croup. They may occasionally cause bronchiolitis and p

1(. #espirator * nc tial Virus #*V3

False espond to +mantidine

True -ay cause bronchiolitis

True -ay cause croup

True -ay cause pneumonia

False -ay be prevented by vaccination

*omments 72 will not respond to amantidine. 1t most commonly cause bronchiolitis and pneumonia. 'ccaThere is no vaccine available.

1 . Par!o!iruses

False *auses oseola 1nfantum

True *auses Erythema 1nfectiousum

False 1s terato(enic

True -ay cause abortion

True -ay cause aplastic crisis in persons with haemolytic anaemias

*omments arvovirus causes erythema infectiousum. +lthou(h it may cause abortion and stillbirths, it is notaplastic crisis in persons with haemolytic anaemias

10. Measles Virus Infection

False *auses a vesicular rash

True -ay cause encephalitis

False -ay respond to acyclovir

True -ay be prevented by %1?



17

True -ay be prevented by vaccination

*omments -easles causes a maculopapular rash. 1t may cause encephalitis. 1t does not respond to acyclovir. be protected by %1?. + live attenuated vaccine is now (iven as part of universal vaccination in

14. #u&ella Virus

True The rash of rubella is similar to that caused by parvo and enteroviruses

True 1s terato(enic

True *on(enital rubella is charaterised by eye, ear and heart defects

True *on(enital rubella is dia(nosed by the findin( of rubella4specific antibody in the cord blood of in

True 1nfants with con(enital rubella poses a (reat infectious ris .

*omments The rash of rubella is similar to that caused by parvo and enteroviruses. 1t is terato(enic, the classrubella consists of eye, ear and heart defects. *on(enital rubella can be dia(nosed by the findin( othe cord blood of infants.1nfants with con(enital rubella poses a (reat infectious ris since they m< year.

26. )u+an T-l +photropic !irus 1 )T%V-13 is associated with

False ur itt9s lymphoma

True +dult T4cell lymphoma

True Tropical 7pastic araparesis

False -ultiple 7clerosis

False od( in9s lymphoma

*omments uman T4lymphotropic virus < ! T624<" is associated with +dult T4cell lymphoma and Tropical

21. )IV Infection +a lead to

True $ementia

True *hronic $iarrhoea



18

True *-2 retinitis

True 'esopha(eal candidiasis

True %on4 od( in9s lymphoma


22. The following +a &e useful for prognostic purposes in )IV-infected indi!idu

False 12 envelope antibody level

True 124p@A anti(en

True *$A count

False 12 pro4viral $%+ in leucocytes

True 12 plasma %+

*omments 12 envelope antibody remains hi(h at a constant level throu(hout the period of infection and ismar er. 124p@A anti(en had been widely used as a pro(nostic mar er in the past but has now be

%+ !viral load". The *$A count provides important information on the sta(e of the disease.

2". chronic carrier state +a occur in the following9

False antavirus 1nfectionFalse epatitis +

True epatitis

True epatitis *

False 7mallpox 1nfection

*omments + chronic carrier state may occur with 2 and *2 infection.

2$. The following +ar7ers are usuall present in a hepatitis 5 carrier with chroni

True be+(

True +nti4 c 1(?

False +nti4 c 1(-



19

True 24$%+

True bs+(

*omments 1n patients with chronic active hepatitis, 2 replication is present and hence 24$%+ and b

bc1(- is normally absent althou(h it may occasionally be detected durin( periods of exacerbati

2'. The following state+ents are true

True *hronic 2 infection may respond to interferon therapy

True *hronic *2 infection may respond to interferon therapy

True *hronic *2 infection may respond to ribavirin therapy

True epatitis $elta infection may be prevented by vaccination a(ainst 2

False epatitis E 1nfection may be prevented by vaccination

*omments *hronic 2 and *2 infection may respond to interferon therapy. *hronic *2 infection mayhowever ribavirin is usually (iven with interferon. epatitis $elta infection may be prevented byThere is no vaccine available a(ainst E2.

2(. The following !iruses can &e trans+itted & &lood

True epatitis +

True 12

True T624<

True 2

True *2

*omments +ll the above viruses may be transmitted by blood

2 . #egarding !iral infection of the central ner!ous s ste+ CN*3

True -enin(itis may occur to(ether with encephalitis



20

True Enteroviruses are one of the commonest causes of *%7 infections in childhood

False 72 encephalitis is a postinfectious encephalomyelitis

True -easles encephalitis is a postinfectious encephalomyelitis

True The detection of antibody in the *7F is a useful dia(nostic mar er

*omments -enin(itis usually occurs with encephalitis. Enteroviruses are one of the commonest causes of *72 encephalitis result from invasion of the virus rather than an aller(ic postinfectious event as i

detection of antibody in the *7F is a useful dia(nostic mar er

20. The following !iruses are associated with gastroenteritis

True +stroviruses

True %orwal 4li e viruses

False icornviruses

True +denoviruses

True otaviruses

*omments +lthou(h enteroviruses may be found in faeces, they are not associated with (astroenteritis

24. The following !iruses are trans+itted fro+ ani+als to hu+ansTrue abies 2irus

False olioviruses

False *-2

True antaviruses

True 6assa Fever 2irus

*omments abies may be transmitted to humans from a variety of mammals. antaviruses and 6assa Feverhumans by rodents.

"6. The following is true of ra&ies !irus

False The ma:ority of cases world4wide result from bat bites



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VIROLOGY MCQ 1