Transporting Your Skin Through Time

Lori BushPresident of Nu Skin

Our Nu Skin Mission

We strive to be a distinctive resource for all who aspire to the physical, emotional, or financial rewards that derive from skin care product leadership.

Healthy, beautiful skin

On a journey through time

?

How will your skin travel through time?

Zoe Diana Draelos, M.D.

Evolution of Skin Care:The Beginning

• Affordable common soap– Increased hygiene and fewer skin

infections– Soap removed too much sebum and

yielded dry skin

Evolution of Skin Care:The Beginning

• Moisturizers needed to counteract the drying effect of soap– Original moisturizers were

petroleum, lanolin– Greasy substances prevented

moisture from evaporating from the skin

Evolution of Skin Care:The Present

• Refined cleansers that provide excellent hygiene, but do not overdry the skin

• Elegant moisturizers that hydrate and retard moisture loss

• Sunscreens that prevent sunburn and function to counteract the aging effects of UV exposure

Present Skin Care Philosophy

• Add to the skin what is missing

• Sophisticated cosmeceutical moisturizers to add vitamins and antioxidants (skin care maintenance)

• Sunscreens to add additional protection from aging (skin care prevention)

Future Skin Care Philosophy

• Adding and supplementing the skin for prevention and maintenance purposes is important

• The step beyond is removal of substances that retard optimal skin functioning

• Add the good, remove the bad

Critical Questions

• What should you add to the skin and what should you remove?

• How do you know what is good and what is bad?

• How do you remove substances from the skin that promote aging?

Skin Aging Concepts

• Skin ages due to UV damage, oxidation

• Oxidation by products accumulate

• Skin aging progresses as byproducts decrease optimal functioning

Satisfied Oxygen Atom

Crippled “Free Radical”

Free Radical Chain Reaction

Antioxidants lose an electron without initiating a chain reaction.

Antioxidants inhibit lipid bi-layer and cell membrane breakdown.

Future Skin Care: Adapting New Technology to Skin

• Rate of tissue aging is slowed in laboratory by placing tissue in special transport media

• Transport media contains substances to remove byproducts from the tissue

• Tissues age at a slower rate due to optimal functioning

Evolution of Skin Care:The Future

• Important active ingredient in transport media is lactobionic acid

• Minimize the damaging effects of:– Oxygen and other pro-oxidants– Transitional metals, such as

iron

Evolution of Skin Care:The Future

• New skin care products utilize transport media technology to aid in the prevention of aging

• Active ingredients placed in moisturizers to hydrate skin

• Adding the good and removing the bad

The Future is Now

• Add to the skin – sun protection– skin moisturizers– skin antioxidants

• Remove from the skin– sebum and environmental dirt– damaging byproducts

Barbara Green, R.Ph., M.S.

Evolution of Hydroxyacid Skin Care

AHAs (glycolic acid, lactic acid)

PHAs (gluconolactone)

Bionic PHAs (lactobionic acid)

New

AHA vs. PHA

glycolic acid

COOH

C OH

gluconolactone

H

H

OH

OH

H

OHH

OH

CH OH

HO

2

PHA: Gluconolactone

• Polyhydroxy AHA (PHA): full strength anti-aging benefits

• Natural component of skin; cell nutrient

• Natural antioxidant/chelator

• Highly moisturizing

• Strengthens skin barrier (published study)

• Non-stinging, non-burning

• Suitable for all skin types including sensitive skin

• No increase in sun sensitivity

Gluconolactone - Chelator

• Dairy - prevents milk stone

• Brewery - prevents beer stones

• Foodstuffs - coagulant for tofu

• Humans - acidify urine to allow exchange

of Mg++ for Ca++ in kidney stones

Lactobionic Acid(Bionic PHA)

• Anti-aging effects (it is an AHA)

• Gentle to skin

• Plumps the skin

• Provides unique skin feel attributes – gel/film forming property

• Suitable for all skin types, even sensitive skin• Moisturizing/water binding: 8 hydroxyl groups

Lactobionic Acid Gel

Weight (g) of water absorbed per mole of substance*

-5

5

15

25

35

45

55

65

75

lactobionic acidglycerolgluconolactonesorbitolglycolic acidcitric acidpropylene glycollactic acidcontrolsalicylic acid

*After exposure to 100 % relative humidity for four hours.

Lactobionic Acid – Skin Protector!

• Antioxidant – Medical use - preservative for organs during

transplantation procedures – it traps metals

• Inhibitor of metalloproteinase enzymes (MMPs)– MMPs degrade skin collagen

– Leads to wrinkles, laxity, visible capillaries

– UV and aging MMP activity

Cumulative Irritation Study 14 days

0

0.5

1

1.5

2

2.5

3

1 2 3 4 5 6 7 8 9 10 11 12 13 14Day

0.1% SLS

Lactobionic acid 4% +Gluconolactone 8%cream0.9% NaCl

MeanScores

n = 24

Nonirritating!

Atopic Dermatitis with PHA Regimen

Before After

Antioxidant Effects

Most Effective

Very Effective

ANTHRALIN HYDROQUINONE BANANA PEEL

oxalic acid oxalic acid oxalic acidascorbic acidcitric acidgluconolactone

ascorbic acid ascorbic acid lactobionic acid citric acid citric acid tartaric acid gluconolactone gluconolactone lactobionic acid lactobionic acid

Anti-oxidant effects on Banana Peel (72 hours)

Gluconolactone

Lactobionic AcidPHAs

prevent oxidativebrowning

AHAs vs. PHAsAnti-aging Effects

AHA vs. PHA Anti-Aging Study

Mean Relative % Improvement(compared to baseline)

0

10

20

30

40

50

Week 12PHA n=30Week 12AHA n=27

Note: All attributes significantly improved from baseline (p<0.05) X: AHA regimen significantly better than PHA regimen

X

PHA Regimen : 14% daily PHA AHA Regimen : 16% daily AHA

AHA vs. PHA Anti-Aging StudyIrritation Assessment

0

0.25

0.5

0.75

1Ery

them

a-A

HA

Eryth

ema-

PHA

Burni

ng-A

HA

Burni

ng-P

HA

Stin

ging

-AH

A

Stin

ging

-PH

A

Mea

ns (

0-3

Scal

e)

BaselineWeek 6Week 12

n=27 (AHA)n=27 (PHA)

* significant improvement from baseline (p<0.05)+ significant worsening from baseline (p<0.05)X burning, stinging significantly worse than PHA regimen

*

*

+ X

+ X+ X

+ X

*

*

(mild)

(none)

PHA SerumAnti-aging Effects

Facial Clinical Evaluation - PHA SerumMean Relative % Improvement

(compared to baseline)

0

20

40

60

80

100

Fine L

ines

Wrin

kles

Pore S

ize

Laxity

Rough

ness

Sallow

ness

Mot

tled P

igm

nt

Per

cent

% Week 6

Week 12

All attributes significantly improved at Weeks 6 and 12 from baseline (p<0.05)

Facial Clinical EvaluationMean Relative % Improvement

(compared to baseline)

200

220

240

260

280

Clarity

Per

cent

% Week 12PHAserum

Significantly improved at Weeks 6 and 12 from baseline (p<0.05)

Total Skin Thickness (Plumping) Mean Relative % Improvement

(compared to baseline)

0

3

6

9

12

Per

cent

%

PHASerum

Untreated

*Significantly increased skin thickness over untreated (p<0.05)

Before

After

Fine LinesSoftened

PHA RegimenStudy

12 weeks

Before After

Smoother, brighter

PHA Regimen Study – 12 weeks

PHA Benefits to Aging Skin

• Anti-aging effects– Smoother, brighter complexion, reduced

appearance of fine lines and wrinkles, increased clarity

• Anti-oxidant/chelator

• Moisturizing

• Gentle enough for sensitive skin

Jan LephartSenior Director of Nu SkinResearch and Development

Tru Targeted Treatments

Tru Targeted TreatmentsEnvironmental

Aging

BiologicalAging

Mechanical Aging

NEW!

Nu Skin

Tru Face Revealing Gel

Nu Skin Tru Face Revealing Gel

• Addresses biological and environmental aging

• Features patented polyhydroxy acid technology

•Lactobionic Acid AND Gluconolactone

• Extremely gentle yet powerful

Nu Skin Tru Face Revealing Gel

• Delivers powerful antioxidants

• Chelates excess iron, reducing potential oxidative damage

• Moisturizes, draws water to skin

• Minimizes appearance of pore size

• Reduces visible effects of photoaging

• Improves skin texture and radiance

• Helps restore youthful cell renewal

• Reveals a smoother, softer complexion

• Perfect for even sensitive, irritable skin

Nu Skin Tru Face Revealing Gel

• Treats mechanical aging

• Features pro-collagen peptide

• Softens and improves the appearance of moderate to deep lines and wrinkles

• Clinical study showed significant wrinkle improvement in 91% of participants

Nu Skin Tru Face Line Corrector

• Combats environmental aging

• Features Kelpadelie, a marine algae extract that is milder to skin than Retinol

• Improves and maintains skin clarity and restores skin radiance

Nu Skin Tru Face Skin Perfecting Gel

Tru Face Revealing Gel - Patented PHA Technology

Tru Face Line Corrector - Pro Collagen Peptide

Tru Face Skin Pefecting Gel - Kelpadelie Algae

Tru Targeted Treatments

Transporting Your Skin Through Time