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1) Somatosensory System
2) Mechanoreceptors / Receptor Potentials
3) Muscle Spindles / GTOs
4) Central Somatosensory Processing
5) Deafferentation / Plasticity
Topic 5 – Somatosensory System
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 20000
Peripheral receptor
Dorsal root ganglion cell
Peripheral axonproximal axon
Spinal cord
"First-order" sensory afferents carry info from peripheral receptors to the spinal cord.
Source: Purves et al. Neuroscience, SinauerAssociates Inc: Massachusetts, 2001.
Vertebra
Dorsal Root Ganglion
White matter
Gray matter
Spinal nerve
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cerebrum
Primary somatic sensory cortex
Ventral posterior lateral nucleus of thalamus
midbrain
mid-pons
Rostral medulla
Caudal medulla
Cervical spinal cord
Lumbar spinal cord
Medial lemniscus
Medial lemniscus
Gracile nucleus (pathways from lower body)
Cuneate nucleus (pathways from upper body)
Internal arcuate fibers
Gracile tract
Cuneate tract
Mechanosensoryreceptors from upper body
Mechanosensoryreceptors from lower body
Afferent pathway for mechanosensoryinformation:
The dorsal column - medial lemniscus (DCML) pathway
Source: Purves et al. Neuroscience, Sinauer Associates Inc: Massachusetts, 2001.
- carries cutaneous and proprioceptive information to the brain
Dorsal root ganglion
cerebrum
Primary somatic sensory cortex
Ventral posterior lateral nucleus of thalamus
midbrain
mid-pons
Rostral medulla
Caudal medulla
Cervical spinal cord
Lumbar spinal cord
Medial lemniscus
Medial lemniscus
Gracile nucleus (pathways from lower body)
Cuneate nucleus (pathways from upper body)
Internal arcuate fibers
Gracile tract
Cuneate tract
Mechanosensoryreceptors from upper body
Mechanosensoryreceptors from lower body
Source: Purves et al. Neuroscience, Sinauer Associates Inc: Massachusetts, 2001.
Dorsal root ganglion
- afferents travel through dorsal column up to the medulla
cerebrum
Primary somatic sensory cortex
Ventral posterior lateral nucleus of thalamus
midbrain
mid-pons
Rostral medulla
Caudal medulla
Cervical spinal cord
Lumbar spinal cord
Medial lemniscus
Medial lemniscus
Gracile nucleus (pathways from lower body)
Cuneate nucleus (pathways from upper body)
Internal arcuate fibers
Gracile tract
Cuneate tract
Mechanosensoryreceptors from upper body
Mechanosensoryreceptors from lower body
Source: Purves et al. Neuroscience, Sinauer Associates Inc: Massachusetts, 2001.
Dorsal root ganglion
1st order afferents synapse with 2nd order neurons in dorsal column nuclei (gracile and cuneate)
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cerebrum
Primary somatic sensory cortex
Ventral posterior lateral nucleus of thalamus
midbrain
mid-pons
Rostral medulla
Caudal medulla
Cervical spinal cord
Lumbar spinal cord
Medial lemniscus
Medial lemniscus
Gracile nucleus (pathways from lower body)
Cuneate nucleus (pathways from upper body)
Internal arcuate fibers
Gracile tract
Cuneate tract
Mechanosensoryreceptors from upper body
Mechanosensoryreceptors from lower body
Source: Purves et al. Neuroscience, Sinauer Associates Inc: Massachusetts, 2001.
Dorsal root ganglion
2nd order neurons travel through internal arcuate and medial lemniscus tracts to the thalamus
cerebrum
Primary somatic sensory cortex
Ventral posterior lateral nucleus of thalamus
midbrain
mid-pons
Rostral medulla
Caudal medulla
Cervical spinal cord
Lumbar spinal cord
Medial lemniscus
Medial lemniscus
Gracile nucleus (pathways from lower body)
Cuneate nucleus (pathways from upper body)
Internal arcuate fibers
Gracile tract
Cuneate tract
Mechanosensoryreceptors from upper body
Mechanosensoryreceptors from lower body
Source: Purves et al. Neuroscience, Sinauer Associates Inc: Massachusetts, 2001.
Dorsal root ganglion
- 2nd order neurons synapse on 3rd order in VPL nucleus of thalamus
- 3rd order neurons travel to S1
Primary somatosensory cortex (S1)
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
Primary Somatosensory CortexPostcentralgyrus
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3a – proprioceptive inputs3b – cutaneous inputs1 – cutaneous inputs2 – proprioceptive inputs
S1 is comprised of sub-areas:
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
S1 - Connectivity
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
Central sulcus
Postcentral gyrus (S1)Postcentral sulcus
thalamus
Receptive Fields
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
S1 neurons have RFs
- smaller RFs in area 3 cells than area 1 and 2 cells
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Topographic Maps -
The arrangement of receptive fields in the somatosensory cortex forms a map of the entire body.
Topographic Maps
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
Each S1 region has its own map
Source: Purves et al. Neuroscience, Sinauer Associates Inc: Massachusetts, 2001.
The more important an area is for tactile discrimination, the larger the representation…
Sensory Homunculus
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Source: Haines, Fundamental Neuroscience, Churchill-Livingstone, 2002
• receptor groups are separated in representation in columns
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
Information in S1 is arranged by: 1. receptor type (columns)
2. location of origin (homunculus)
In general -The primary somatosensory cortex integrates info from somatosensory input
- Lesions affect position sense, ability to discriminate size, texture, shape etc…
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Somatosensory information is important in the control of movement -
• This can be demonstrated using muscimol…
A. Muscaria
Mushroom species.
Source of muscimol
GABA
Muscimol
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
Ipsilateral hand
Contralateral hand
muscimol injected into area 2
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Secondary Somatosensory Area
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
Secondary Somatosensory Area
- overall function is largely unknown
- large, bilateral receptive fields
- may have a role in integration of submodalities of somatosensation
Sensory Gating -
The ability to focus on relevant sensory information while disregarding less important information.
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Sensory Gating -- The CNS can control ascending pathways
- achieved by inhibition
- inhibition can occur along the DCML pathway
1) Somatosensory System
2) Mechanoreceptors / Receptor Potentials
3) Muscle Spindles / GTOs
4) Central Somatosensory Processing
5) Deafferentation / Plasticity
Topic 5 – Somatosensory System
Plasticity
- Sensory and motor maps are modifiable by training or use.
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Somatosensory maps are modifiable by training or use.
Monkeys trained to obtain food using only tips of middle 3 fingers 1 hour / day for 3 months.
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
Somatosensory maps are modifiable by training or use.
Training
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 2000
Representations of digits in area 3b before and after training.
Deafferentation and Plasticity
Peripheral lesions/ amputations result in modified somatosensory maps.
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Source: Ramachandran, PNAS, 1993, 90: 10413-10420.
Amputation
• referred sensations between body parts ("phantom limbs")
Source: Purves et al. Neuroscience, Sinauer Associates Inc: Massachusetts, 2001.
Re-mapping after amputation
Hand region
Face region
Arm region
Source: Haines, Fundamental Neuroscience, Churchill-Livingstone, 2002
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Peripheral Lesions
Source: Kandel et al., Principles of Neural Science, McGraw Hill, 20000
Other sources of sensory information (incl vision, vestibular and auditory) are also important for movement!