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Tooth Regeneration
Kaitlin Bramhall
American alligators have similar tooth structure to humans
They can regrow teeth up to 50 times! How can scientists mimic this for humans?
Background
Dr. Rena D’Souza has studied using stem cells from wisdom and baby teeth to regrow teeth pulp
Ping Wu and his team are trying to replicate how alligators regrow their teeth
Studies…
PNAS Journal - Ping Wu
Regenerating tooth pulp can put an end to root canal procedures
Possible full tooth replacement, ending dental implants
Could lead to more bone and tissue regeneration
Benefits
50% of Americans have a cavity that can lead to a root canal by the age of 15
Root Canals
Pain LevelAge
Mild Severe Intense Unbearable
18-20 11.8% 18.2% 50.0% 0%
21-30 29.4% 18.2% 33.3% 33.3%
31-40 29.4% 31.8% 16.7% 66.7%
41-50 17.6% 31.8% 0% 0%
51-60 5.9% 0% 0% 0%
Dental Implants: Painful Expensive Lots of risks
Tooth Replacement
Cosmetic Dentistry of SD
The possibilities are endless!!
D’Souza, Dr. Rena. The Wall Street Journal. 2 July 2013. University of Utah’s School of Dental Medicine. http://www.foxnews.com/health/2013/07/02/no-more-root- canals-scientists-aim-to-regrow-teeth-using-stem-cells/ (10 Nov. 2013).
Jafarzadeh, Hamid and Christopher Udoye. “Pain during root canal treatment: an Investigation of Patient Modifying Factors.” The Journal of Contemporary Dental Practice. July 2011. 302-304.
Wu, Ping. “Specialized stem cell niche enables repetitive renewal of alligator teeth.” Proceedings of the National Academy of Science of the United States of America.28 March 2013.
Works Cited