INTRODUCTION

In July 2009, the 36th International Congress ofPhysiological Sciences (IUPS2009) was held inKyoto, Japan. Few years prior to the 36th IUPS con-gress, several Japanese physiologists, includingMasataka Murakami (National Institute for NaturalSciences, Okazaki) and I discussed the possibilityof holding an IUPS satellite symposium in the fieldregarding the “Exocrine Secretion.” We also talkedthis matter with scientists out of country ; i.e. , IreneSchulz (University of Konstanz, Konstanz), David I.Cook and Anuwat Dinudom (University of Sydney,Australia), and Ivana Novak (University of Copen-hagen, Denmark), and finally made decision to holdthe symposium under the name of “InternationalSymposium on Exocrine Secretion. (ISES).”

International Symposium on Exocrine Secretion(ISES) was the name given to the symposium byDr. John A. Young (the former IUPS Commissionfor Gastrointestinal Physiology), which he organ-ized in 1990 in Leura, Australia. He assigned theseries number “9” (thus designating this sympo-sium as 9th ISES) because 8 identical but vari-ously named conferences (1-8) had been held be-tween 1962 and 1988 before the one in Leura (9).Dr. Young hoped that these symposia on exocrine

secretion would continue to be held in the future,and it was for this reason that he called it the“ninth” (9). The 10th ISES was held in 1993 inFreiburg, Germany, having been organized by Dr.Rainer Greger (10). However, more than 15 yearshave passed since this last ISES. During this timea lot of knowledge has been accumulated and greatprogress has been made in this field. These situ-ations also prompted us to consider holding theISES as 11th meeting, and under the subtitle, “Exo-crine Secretion-Mechanism and Disease” in orderto emphasize our current understanding about themechanisms of exocrine secretion in a broad con-text, and to correlate the relevance of this basicknowledge with disease.

REPORT ON RESEARCH MEETING

The 11th International Symposium on ExocrineSecretion (ISES) was organized by a chairman,Kazuo Hosoi, (the University of Tokushima, Japan),and vice chairs, Masataka Murakami, (Institute forPhysiological Sciences, Japan) and Ivana Novak,(University of Copenhagen, Denmark). Other mem-bers of organizing committee are listed in Table 1.

The conference was held at Kuramoto Campus,the University of Tokushima during July 23-25,2009. The places for symposium and poster presen-tations were at Nagai Memorial Hall and Informa-tion Plaza of the Graduate School of Pharmaceuti-cal Sciences, respectively. In the opening ceremonyon the 1st day, Dr. Toshihiro Aono, the presidentof the University of Tokushima, and Dr. Yuji Sano

PREFACE

The report on the 11th International Symposium on Exo-crine Secretion

Kazuo Hosoi1, Masataka Murakami2, and Ivana Novak3

1Department of Molecular Oral Physiology, Institute of Health Biosciences, the University of

Tokushima Graduate School, Tokushima, Japan ; 2Nano-Structure Physiology, Center for Integrative

Bioscience, NIPS, National Institute for Natural Sciences, Okazaki, Japan ; and 3Department of Biology,

University of Copenhagen, Copenhagen, Denmark

Keywords : exocrine secretion, exocrine glandJ. Med. Invest. 56 Suppl. : 171-178, December, 2009

Received for publication December 24, 2009 ; accepted Decem-ber 30, 2009.

Address correspondence and reprint requests to Kazuo Hosoi,Department of Molecular Oral Physiology, Institute of HealthBiosciences, the University of Tokushima, Graduate School,Kuramoto-cho, Tokushima, 770-8504, Japan and Fax : +81-88-633-7324.

The Journal of Medical Investigation Vol. 56 Supplement 2009

171

Table 1 Organizing Committee

1. Advisory Committee Members

Barry E. Argent First Department of Medicine, Institute for Cell and Molecular Biosciences, University of Newcastle

upon Tyne,UK.

R. Maynard Case Faculty of Life Sciences, University of Manchester, UK.

Edward W. Gresik Faculty of Medicine, The City University of New York Medical School, USA.

Shmuel Muallem Department of Physiology, University of Texas Southwestern Medical Center,USA

*Ivana Novak Department of Biology, University of Copenhagen, Denmark

Paul M. Quinton Department of Pediatrics, School of Medicine, UCSD, USA

Irene Schulz Department of Biology, University of Konstanz, Konstanz,Germany

Jeffrey J. Wine Cystic Fibrosis Research Laboratory, Stanford University, USA

2. International Committee Members

Indu S. Ambudkar Secretory Physiology Section, Gene Therapy and Therapeutics Branch, National Institute of Dental

And Craniofacial Research, NIH, USA

David I. Cook Department of Physiology, School of Medical Sciences, University of Sydney, Australia

Mike A. Gray School of Cell & Molecular Biosciences, University Medical School,UK

Christoph Korbmacher Institut fur Zellulare und Molekulare Physiologie Universitat Erlangen-Nurnberg, Germany

Min Goo Lee Department of Pharmacology, Institute of Gastroenterology, Yonsei University College of Medicine,

Korea

Martin C. Steward Faculty of Life Sciences, University of Manchester Core Technology Facility, UK

3. Domestic Committee Members (Japan)

Chikara Hirono Department of Oral Physiology, Hiroshima University Graduate School of Biomedical Sciences

**Kazuo Hosoi Institute of Health Biosciences, the University of Tokushima Graduate School

Kiyotoshi Inenaga Department of Biosciences, Kyushu Dental College

Hiroshi Ishiguro Laboratory of Human Nutrition, Nagoya University Graduate School of Medicine

Toru Ishikawa Laboratory of Physiology, Department of Biomedical Sciences, Graduate School of Veterinary

Medicine, Hokkaido University

Hiroshi Kido Division of Enzyme Chemistry, The Institute for Enzyme Research, the University of Tokushima

Toshio Matumoto Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, the University of

Tokushima Graduate School

Ryuji Matsuo Department of Oral Physiology, Okayama University Graduate School of Medicine and Dentistry and

Pharmaceutical Sciences

*Masataka Murakami Nano-Structure Physiology, Center for Integrative Bioscience, NIPS, National Institute for Natural

Sciences

Tetsuji Nakamoto Department of Oral Functional Reconstruction, Kyushu Dental College

Hiroshi Shiota Department of Ophthalmology, Institute of Health Biosciences, the University of Tokushima

Graduate School

Saburo Sone Department of Respiratory Medicine and Rheumatology, Department of Medical Oncology, Institute of

Health Biosciences, the University of Tokushima Graduate School

Hiroshi Sugiya Department of Physiology and Research Institute of Oral Science, Nihon University School of

Dentistry at Matsudo

Taishin Takuma Department of Biochemistry, School of Dentistry, Health Sciences, University of Hokkaido

Masato Yasui Department of Pharmacology, Keio University School of Medicine

4. Local Acting Members (The host Department)

Tetsuya Akamatsu Institute of Health Biosciences, the University of Tokushima Graduate School

Takahiro Hasegawa Institute of Health Biosciences, the University of Tokushima Graduate School

Chenjuan Yao Institute of Health Biosciences, the University of Tokushima Graduate School

Shinsuke Matsuo Institute of Health Biosciences, the University of Tokushima Graduate School

** Chairman, * Vice Chair

K. Hosoi, et al. Report on the 11th ISES172

(as a representation of Kamon Iizumi, the governorof Tokushiama prefecture), a vice-director of theDepartment of Health Policy and Health Service,Tokushima Prefectural Government presented theirmessage to the ISES participants. Mr. Hideki Hara,the Mayor of Tokushima City also sent the messageof celebration via telegram.

The 11th ISES organizer planned to include 1plenary lecture, 2 keynote lectures, and sympo-sia and poster presentations in 6 relevant fields.The plenary lecture was delivered by professorAlan S. Verkman (University of California, San Fran-cisco, USA) under the title of “The many roles ofaquaporins in mammalian physiology,” while 2 key-note lectures entitled “Salivary gland and autoimmu-nity” and “The exocrine gland fluid secretion mecha-nism” were given by professor Yoshio Hayashi (theUniversity of Tokushima Graduate School, Japan)and professor James E. Melvin (University of Roch-ester Medical Center, USA), respectively.

All papers (oral and poster) were presented un-der following categories ; 1, Development, Regenera-tion, and Tissue Engineering of the Glandular Tissue,2, Response of the Glandular Tissue to EnvironmentalStress and Neural/Hormonal Control, 3, Aquaporin andIon Channel/Transporter : Physiology and Disease(Symposium : Part-I & Part-II), 4, Signal Transductionof the Glandular Tissue, 5, Membrane Trafficking andMolecular/Cellular Dynamics in the Exocrine Secretion,6. Regulation of Exocrine Glands by Taste Stimulation(Ajinomoto-sponsored Symposium).

The ISES office received 35 symposium papers(oral presentation) and 45 papers for poster pres-entations besides a plenary and keynote lectures.Thirty three scientists from oversea and 117 fromwithin the country attended the ISES. The partici-pating countries were USA, Canada, England, Ger-many, Denmark, China, Korea, Australia, Russia,and Japan. During the period of the symposium, thecommittee members evaluated the posters. Five ex-cellent posters, including the best one, were se-lected by the strict evaluation by committee mem-bers ; the poster awards were given to these pre-senters at the farewell party on the 3rd day. In the3rd day afternoon the strong shower was fallen, butweather on the first and second days was very nice.The group photograph was taken on the 2nd day infront of the Nagai Memorial Hall (Fig. 1) and at theTokushima Washington Hotel Plaza (Fig. 2). OnJuly 26th, the ISES served the “After-ConventionTour,” and those who want to attend the IUPS meet-ing visited several spots in Tokushima before leaving

for Kyoto. The bus brought these participants toKyoto after this excursion.

The organizing committee agreed to publish theproceedings of the 11th ISES. Fortunately, quitemany participants approved to submit the proceed-ings, and we received 61 papers out of 83 presen-tations. We, the organizer, believe that this interna-tional symposium and its proceedings match expec-tations for presentations of the highest scientificmerit and contribute to the development of newmedical cures and the promotion of public health.We also hope that the tradition of this InternationalSymposium series promoted by Dr. Young will becontinued by coming generations.

REFERENCES

1. Sreebney LM, Meyer J (eds) : Salivary Glandsand their Secretions. Pergamon Press, Oxford,1964

2. Schneyer LM, Schneyer CA (eds) : SecretaryMechanism of Salivary Glands. Academic Press,New York, 1967

3. Botelho SY, Brooks FP, Shelley, WB (eds) :The Exocrine Glands. University of Pennsylva-nia Press, Philadelphia, 1969

4. Thorn, NA, Petersen OH (eds) : SecretoryMechanisms of Exocrine Glands. Munksgaard,Copenhagen, 1974

5. Zelles, T (eds) : Saliva and Salivation (Advancesin Physiological Sciences Vol 28). AcademiaiKiado and Pergamon Press, Budapest and Ox-ford, 1981

6. Case RM, Garner A, Turnberg LA, Young JA(eds) : Electrolyte and Water Transport AcrossGastrointestinal Epithelia. Raven Press, NewYork, 1982

7. Case RM, Lindgard JM, Young JA (eds) : Se-cretion : Mechanisms and Control. ManchesterUniversity Press, Manchester, 1984

8. Wong PYD, Young JA (eds) : Exocrine Secre-tion. University of Hong Kong Press, HongKong, 1988

9. Wong PYD, Young JA (eds) : 9th InternationalSymposium on Exocrine Secretion-ExocrineSecretion II. United League Graphic & PrintingCo. Ltd., Hong Kong, 1990

10. Frömter E, Greger R, Petersen OH : Interna-tional Symposium on Exocrine Secretion, Ab-stract book, Freiburg, Germany, 1993

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ACKNOWLEDGMENT

The organizers of the ISES appreciate the follow-ing associations/companies for their support of thesymposium.

1. All programs and activities of this symposiumwere financially supported by Setsuro Fujii Memo-rial : The Osaka Foundation for Promotion of Funda-mental Medical Research, Sankyo Foundation of LifeScience, The Novartis Foundation (Japan) for the Pro-motion of Science, Federation of Pharmaceutical Manu-facturers’ Association of Japan*, Tokushima MedicalAssociation, Tokushima Pharmaceutical Association,Tokushima Dental Association, Sony Corporation, HoyaCorporation, Tokushima Prefecture Tourist Association,and Ajinomoto Co., Inc.

2. We express our appreciation to the organiza-tions described below for their partnership with the11th ISES ; Tokushima Prefecture, Tokushima City,The Molecular Biology Society of Japan, Japan Societyfor Cell Biology, The Zoological Society of Japan, TheJapanese Association of Anatomists, Japan SalivaryGland Society, Physiological Society of Japan, TheJapanese Biochemical Society, and Japanese Associa-tion for Oral Biology.

3. We express our appreciation to the associationsand companies described below for their additionalfinancial support ; Otobe Co., Ltd. ; Calpis Co., Ltd. ;Gakkenshoin Ltd. ; Nankodo Co., Ltd. ; Med ShirotoriCo., Ltd. ; Sakurakai Medical corporation ; Ipsen Ltd. ;Takacho Ltd. ; Awa Kasei Ltd. ; Daiichikikai Co., Ltd. ;Japan SLC, Inc. ; Nihon Denshi Kiki Co. Ltd. ; MoritaCorporation ; Yakukensha Co., Ltd. ; Osawa ShokaiCo., Ltd.

4. This symposium was hosted by The Departmentof Molecular Oral Physiology, Institute of Health Bi-osciences, the University of Tokushima Graduate School,and co-hosted by Institute of Health Biosciences, the

University of Tokushima Graduate School, and the Uni-versity of Tokushima Graduate School of Oral Sciences.

* The following members in the Association sponsoredthe present symposium : Asahi Kasei Corporation ; ASKAPharmaceutical Co., Ltd. ; Astellas Pharma Inc. ;AstraZeneca K.K. ; Alfresa Pharma Corporation ; EikenChemical Co., Ltd. ; Eisai Co., Ltd. ; SSP Co., Ltd. ;Elmed Eisai Co., Ltd. ; Otsuka Pharmaceutical Co., Ltd. ;Otsuka Pharmaceutical Factory, Inc. Ono PharmaceuticalCo., Ltd. ; Kaken Herbal Medicine Ltd. ; KakenPharmaceutical Co., Ltd. ; Kissei Pharmaceutical Co.,Ltd. ; Kyorin Pharmaceutical Co., Ltd. ; Kyowa HakkoKirin Co., Ltd. ; GlaxoSmithKline K.K. ; KracieHoldings, Ltd. ; Kowa Co., Ltd. ; Sato Pharmaceutical Co.,Ltd. ; Sanofi-Aventis K.K. ; Sawai Pharmaceutical Co.,Ltd. ; Santen Pharmaceutical Co., Ltd. ; Sanwa KagakuKenkyusho Co., Ltd. ; Schering-Plough K.K. ; Shionogi &Co., Ltd. ; Zeria Pharmaceutical Co., Ltd. ; Daiichi SankyoCo., Ltd. ; Taisho Pharmaceutical Co., Ltd. ; DainipponSumitomo Pharma Co., Ltd. ; Taiho Pharmaceutical Co.,Ltd. ; Takeda Bio Development Center Limited ; TakedaPharmaceutical Co., Ltd. ; Mitsubishi Tanabe PharmaCorporation ; Chugai Pharmaceutical Co., Ltd. ;Tsumura & Co. ; Teijin Pharma Limited ; TerumoCorporation ; Toa Eiyo Ltd. ; Towa Pharmaceutical Co.,Ltd. ; Toyoma Chemical Co., Ltd. ; Torii PharmaceuticalCo., Ltd. ; Eli Lilly Japan K.K. ; Nippon Kayaku Co., Ltd. ;Nippon Pharmaceutical Co., Ltd. ; Nippon Shinyaku Co.,Ltd. ; Nihon Pharmaceutical Co., Ltd. ; Nippon ZokiPharmaceutical Co., Ltd. ; Japan Tobacco Inc. ; NipponBoehringer Ingelheim Co., Ltd. ; Nipro PharmaCorporation ; Novartis Pharma K.K. ; Bayer AG Ltd. ;Banyu Pharmaceutical Co., Ltd. ; Pfizer Japan Inc. ; FusoPharmaceutical Industries, Ltd. ; Bristol-Myers SquibbCompany ; Mylan Inc. ; Maruishi Pharmaceutical Co.,Ltd. ; Maruho Co.,Ltd. ; Minophagen Pharmaceutical Co.,Ltd. ; Meiji Seika Kaisha, Ltd. ; Mochida PharmaceuticalCo., Ltd. ; Yakult Honsha Co., Ltd. ; Rohto PharmaceuticalCo., Ltd. ; Wyeth K.K. ; Wakamoto Pharmaceutical Co.,Ltd.

K. Hosoi, et al. Report on the 11th ISES178