The Physis: Fundamental Knowledge to a Fantastic Future through Research

February 7-9, 2018 / Hyatt Rosemont Hotel / Rosemont, IL Symposium Co-Chairs: Matthew Halanski, MD and Todd Milbrandt, MD

S Y M P O S I U M A G E N D A

Wednesday, February 7, 2018 6:00 – 7:00 PM Symposium Check In Rooms TBD 7:00 – 9:00 PM Networking Reception / Young Investigator Poster Session

Thursday, February 8, 2018 7:00 – 7:45 AM Breakfast

7:45 – 8:00 AM Symposium Welcome and Overview Matthew Halanski, MD University of Wisconsin

Session I: The Normal Physis Moderator: Michelle Caird, MD

8:00 – 8:05 AM Session Introductions Michelle Caird, MD University of Michigan

8:05 – 8:30 AM 1) Growth Plate Development and Closure From Embryo to Adult Ernestina Schipani, PhD University of Michigan

8:30 – 8:55 AM 2) Growth Plate Biology - Cells and Local Signaling Henry Kronenberg, MD Massachusetts General Hospital

8:55 – 9:20 AM 3) Growth Plate Biology - Mechanobiology Rosa Serra, PhD University of Alabama at Birmingham

9:20 – 9:45 AM

4) Growth Plate Biology - Endocrine System: Growth Plate and Hormones Ola Nilsson, MD Karolinska Institutet

9:45 – 10:05 AM Questions and Answers 10:05 – 10:15 AM BREAK -

Session II: The Abnormal Physis Moderator: William Mackenzie, MD

10:15 – 10:20 AM Session Introductions William Mackenzie, MD Alfred I. Dupont Hospital for Children

10:20 – 10:45 AM

5) Genotype to Phenotype: Understanding Molecular Cause and Clinical Picture in Skeletal Dysplasia I Matthew Warman, MD (TBD) Boston Children’s Hospital

10:45 – 11:10 AM

6) Genotype to Phenotype: Understanding Molecular Cause and Clinical Picture in Skeletal Dysplasia II Benjamin Alman, MD Duke University Medical Center

11:10 – 11:35 AM

7) Current Surgical Treatments to Address Physeal Abnormalities in Skeletal Dysplasia I William Mackenzie, MD Alfred I. Dupont Hospital for Children

11:35 AM – 12:00 PM

8) Current Surgical Treatments to Address Physeal Abnormalities in Skeletal Dysplasia I Klane White, MD Seattle Children’s Hospital

12:00 – 12:25 PM

9) Current and Future Approaches to Improve Physis in Skeletal Dysplasia Daniel Hoernschemeyer, MD University of Missouri

12:25 – 12:45 PM Questions and Answers

12:45 – 1:45 PM

Networking Lunch

Session III: The Mis-Regulated Physis Moderator: Benjamin Alman, MD

1:45 – 1:50 PM Session Introductions Benjamin Alman, MD Duke University Medical Center

1:50 – 2:15 PM 10) Global Mis-Regulation: Short Stature vs Gigantism Francesco De Luca, MD Drexel University

2:15 – 2:40 PM 11) Medical Treatments for global Physeal Mis-regulation Jan-Maarten Wit, MD, PhD Leiden University Medical Center, The Netherlands

2:40 – 3:05 PM 12) Focal Mis-Regulation: Hemihypertrophy/Hemiatrophy Benjamin Alman, MD Duke University Medical Center

3:05 – 3:30 PM 13) Evening Out Limbs: Epiphysiodesis and Distraction Osteogenesis Ken Noonan, MD University of Wisconsin

3:30 – 3:55 PM Questions and Answers

Session IV: Cutting Edge: Young Investigator Research Presentations Moderator: Matthew Halanski, MD

3:55 – 4:00 PM Session Introductions Matthew Halanski, MD University of Wisconsin

4:00 – 4:15 PM 14) Young Investigator Paper Presentation TBD

4:15 – 4:30 PM 15) Young Investigator Paper Presentation TBD

4:30 – 4:45 PM 16) Young Investigator Paper Presentation TBD

4:45 – 5:00 PM 17) Young Investigator Paper Presentation TBD

5:00 – 5:15 PM 18) Young Investigator Paper Presentation TBD

5:15 – 5:35 PM Questions and Answers 5:35 – 6:15 PM BREAK - 6:30 – 8:30 PM Group Dinner Outing TBD

Friday, February 9, 2018 7:30 – 8:00 AM Breakfast

8:00 – 8:05 AM Morning Welcome Todd Milbrandt, MD Mayo Clinic

Session V: The Sick Physis Moderator: Todd Milbrandt, MD

8:05 – 8:10 AM Session Introductions Todd Milbrandt, MD Mayo Clinic

8:10 – 8:35 AM 19) Abnormalities in Bone Mineralization (TBD)

8:35 – 9:00 AM 20) Medical Treatments of Abnormal Bone Mineralization David Deyle, MD Mayo Clinic

9:00 – 9:25 AM 21) Obesity and the Physis: Pathophysiology and Clinical Effects I Shawn Gilbert, MD University of Alabama Birmingham

9:25 – 9:50 AM 22) Obesity and the Physis: Pathophysiology and Clinical Effects II Sanjeev Sabharwal, MD, MPH Rutgers University

9:50 – 10:15 AM

23) Surgical Treatments for Angular Deformities - Guided Growth, Osteotomies Peter Stevens, MD University of Utah

10:15 – 10:40 AM Questions and Answers 10:40 – 10:55 AM BREAK -

Session VI: The Injured Physis Moderator: Jonathan Scheonecker, MD

10:55 – 11:00 AM Session Introductions Jonathan Scheonecker, MD Vanderbilt University

11:00 – 11:25 AM

24) Fractures and Overuse injuries to the Physis; Classification and Consequences to Growth Noelle Larson, MD (TBD) Mayo Clinic

11:25 – 11:50 AM

25) Infection, Neoplasm, and the Effects of Treatment on the Growth Plate Jonathan Scheonecker, MD Vanderbilt University

11:50 AM - 12:15 PM

26) Current and Future Treatments of the Injured Physis Todd Milbrandt, MD Mayo Clinic

12:15 – 12:40 PM 27) Bioengineering and the Physis - Role of Stem Cells and Scaffolds Wan-Ju Li, PhD University of Wisconsin

12:40 – 1:00 PM Questions and Answers

1:00 – 1:10 PM Future Research Directions / Next Steps Matthew Halanski, MD and Todd Milbrandt, MD

1:10 – 2:00 PM Lunch / Symposium Conclusion Symposium Participants are expected to stay for the duration of the symposium and should plan flights with

departures no earlier than 3:30 PM.