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THE NEW APPROACH
Introduction
For a long period of time it was state of the art to design drugs displaying one definedpharmacological mode of action.
These drugs failed in the approach to curecomplex diseases!
Recently the medical community postulated the need for drugs displaying a mode of action resulting in pleiotropic effects for treatment of complex diseases like CNS injury or neurodegeneration.
Introduction
The mature central nervous system has limited capacity for self-
renewal and repair after injury or neurodegeneration, therefore
therapeutic strategies with effects similar to neurotrophic factors
resulting in pleiotropic effects are required.
Cerebrolysin acts similar to neurotrophic factors and is
therefore an optimal treatment strategy after CNS injury or
neurodegeneration.
Cerebrolysin
NEUROTROPHIC MECHANISM
neur
onal
sur
viva
l
neur
opro
tect
ion
neur
opla
stic
ity
neur
ogen
esis
Cerebrolysin – Indications
DEMENTIASTROKE
TBI
Protein powder
Cerebrolysin Concentrate
Starting material
Active Pharmaceutical Ingredient
Enzymatic hydrolysis
Molecular weight cut-off filtration
Addition of amino acids
Ethanol precipitation
Cerebrolysin – Characterisation
Cerebrolysin – Mode of action
Cerebrolysin, a balanced peptide preparation acting
like neurotrophic factors.
General Pharmacodynamics (PD)
Special Pharmacodynamics (PD)
The neurotrophic mechanism of Cerebrolysin results in
pleiotropic effects:
• neuronal survival
• neuroprotection
• neuroplasticity
• neurogenesis
Cerebrolysin – General PD
Cerebrolysin – General PD
Neuronal survival
Neurotrophic factors exert survival-promoting and trophic actions on neuronal cells to avoid neuronal atrophy, hypofunction and cell death.
Cerebrolysin – General PD
Neuroprotection
Neurotrophic factors limit neuronal dysfunction and attempt to maintain the highest possible integrity of cellular interactions in the brain under detrimental conditions.
Cerebrolysin – General PD
Neuroplasticity
Neurotrophic factors enable neuroplasticity, a process which allows the brain to adapt by "re-wiring" in response to changes in the environment and which allows the regrowth of damaged neuronal processes.
Cerebrolysin – General PD
Neurogenesis
Neurotrophic factors induce differentiation of progenitor cells to form neurons, which become functionally integrated into the surrounding brain tissue during pre-natal development but also throughout adulthood.
Cerebrolysin – General PD
Cerebrolysin – General PD
Cerebrolysin – Special PD
Efficacy of Cerebrolysin has been proven in several in-
vitro and in-vivo experiments with model systems for
• Dementia
• Stroke
• TBI
Cerebrolysin – Special PD
Model systems for diseases:
DEMENTIA
STROKE
TBI
Cerebrolysin – Special PD
Findings in Dementia Models:
- Cerebrolysin decreases A deposition by regulating APP maturation.
- Cerebrolysin acts as a synaptic modulator to promote integrity of neuronal
circuits.
- Cerebrolysin restores neuronal cytoarchitecture resulting in improved
behavioral performance.
- Cerebrolysin stimulates neurogenesis in the dendate gyrus, which might
provide a basis for neuronal replacement therapy in neurodegenerative
diseases.
Cerebrolysin – Special PD
Findings in Stroke Models:
- Cerebrolysin stabilizes cytoskeleton by inhibition of calpain.
- Cerebrolysin stimulates neurogenesis to promote integrity of neuronal
circuits, a potential mechanisms for self-repair after stroke.
- Cerebrolysin decreases infarct volume.
- Cerebrolysin limits edema formation.
- Cerebrolysin promotes functional recovery.
Cerebrolysin – Special PD
Findings in TBI Models:
- Cerebrolysin prevents apoptosis of lesioned motoneurons.
- Cerebrolysin promotes functional recovery.
Cerebrolysin – Summary
Cerebrolysin, a balanced peptide preparation acting like
neurotrophic factors.
The neurotrophic mechanism of Cerebrolysin results in
pleiotropic effects:
• neuronal survival
• neuroprotection
• neuroplasticity
• neurogenesis
Cerebrolysin – Summary
Efficacy of Cerebrolysin has been proven in several in-
vitro and in-vivo experiments with model systems for
• Dementia
• Stroke
• TBI
Cerebrolysin – Summary
Cerebrolysin is an optimal treatment strategy after
CNS injury or neurodegeneration.
Cerebrolysin – Conclusion
