The Fine Chemical Benchmarking Service - Contents pages Fine Chemical...The Fine Chemical Benchmarking Service . Part 1 . The Pharmaceutical Fine Chemical Industry - Current Status

The Fine Chemical Benchmarking Service

Part 1

The Pharmaceutical Fine Chemical Industry

- Current Status and Trends -

June 2013

JR

Jan Ramakers Fine Chemical Consulting Group

JR


http://www.Jan-Ramakers.com

The Fine Chemical Benchmarking Service – Part 1

Jan Ramakers Fine Chemical Consulting Group June 2013

1

Contents 1. The pharmaceutical Product Life Cycle ..................................................................................3

1.1. The development phase ..................................................................................................4

Screening ............................................................................................................................4 Preclinical phase .................................................................................................................5 The clinical phase ...............................................................................................................6 Phase I ................................................................................................................................6 Phase II ...............................................................................................................................6 Phase III ..............................................................................................................................6 Registration .........................................................................................................................6 Phase IV .............................................................................................................................6

1.2. Success rate and cost of development ...........................................................................7 1.3. Commercial life ............................................................................................................. 13

The patented life .............................................................................................................. 13 The generic phase ........................................................................................................... 13

2. The pharmaceutical value chain .......................................................................................... 16

2.1. The chain ...................................................................................................................... 16 2.2. The value of the chain .................................................................................................. 18 2.3. Market breakdown ........................................................................................................ 20

3. Types of companies and organisations involved ................................................................. 21

3.1 Development .................................................................................................................. 21

Screening ......................................................................................................................... 21 Preclinical phase .............................................................................................................. 21 Clinical phase .................................................................................................................. 21

3.2 Commercial life .............................................................................................................. 22

The patented life .............................................................................................................. 22 The generic life ................................................................................................................ 23

4. Company and market characterisation ................................................................................ 24

4.1. Pharmaceuticals ........................................................................................................... 24

The market ....................................................................................................................... 24 The companies ................................................................................................................ 28 Trends .............................................................................................................................. 33

4.2. Drug discovery .............................................................................................................. 34



Jan Ramakers Fine Chemical Consulting Group June 2013

2

4.3. Computational modelling .............................................................................................. 36 The market ....................................................................................................................... 36 The companies ................................................................................................................ 36 Trends .............................................................................................................................. 38

4.4. Kilo shops ..................................................................................................................... 39


4.5. Fine chemicals .............................................................................................................. 41


4.6. Contract research ......................................................................................................... 50


4.7. Excipients ..................................................................................................................... 53


5. Structure and development of the business ........................................................................ 54

5.1. Pharma – characteristics & development ..................................................................... 56

Market development pharmaceuticals 1999 – 2017 ........................................................ 56 5.2. Drug Discovery – characteristics & development ......................................................... 58

Market development drug discovery 1999 – 2017 .......................................................... 58 5.3. Computational Modelling – characteristics & development .......................................... 59

Market development computational modelling 1999 – 2017 ........................................... 59 5.4. Kilo shops – characteristics & development ................................................................. 60

Market development kilo shops 1999 – 2017 .................................................................. 60 5.5. Fine Chemicals – characteristics & development ......................................................... 61

Market development fine chemicals 1999 – 2017 ........................................................... 62 5.6. CRO’s – characteristics & development ....................................................................... 63

Market development CRO’s 1999 – 2017 ....................................................................... 64 5.7. Excipients – characteristics & development ................................................................. 65

6. Opportunities and threats for the fine chemical industry ..................................................... 66

6.1. Opportunities ................................................................................................................ 66 6.2. Threats .......................................................................................................................... 67


Part 2

The leading manufacturers of

Fine Chemicals & Life Science Intermediates

May 2013

JR


JR



Jan Ramakers Fine Chemical Consulting Group May 2013

1

Contents A. Data for 2012 – full year .........................................................................................................2 1. Overview .................................................................................................................................2

1.1. The leading fine chemical companies in 2012 ................................................................3 1.2. Profitability in 2012 ....................................................................................................... 16 1.3. Technologies ................................................................................................................ 18 1.4. Grouping by technological breadth ............................................................................... 20

2. Company profiles - current .................................................................................................. 21

2.1. Acros Organics ............................................................................................................. 22 2.2. Aesica ........................................................................................................................... 29 2.3. Albemarle ...................................................................................................................... 33 2.4. Ampac Fine Chemicals ................................................................................................. 46 2.5. Archimica ...................................................................................................................... 58 2.6. Arkema ......................................................................................................................... 72 2.7. Axyntis .......................................................................................................................... 81 2.8. BASF ............................................................................................................................ 89 2.9. Boehringer Ingelheim ................................................................................................. 105 2.10. Borregaard Synthesis ............................................................................................... 111 2.11. CABB ........................................................................................................................ 121 2.12. Cambrex ................................................................................................................... 130 2.13. Chemetall .................................................................................................................. 145 2.14. Dottikon ..................................................................................................................... 155 2.15. Dow ........................................................................................................................... 165 2.16. DSM .......................................................................................................................... 178 2.17. Evonik ...................................................................................................................... 201 2.18. Isochem .................................................................................................................... 221 2.19. Koei Chemical........................................................................................................... 230 2.20. Lonza ........................................................................................................................ 237 2.21. Nippon Soda ............................................................................................................. 268 2.22. Novasep .................................................................................................................... 274 2.23. Omnichem ................................................................................................................ 284 2.24. PCAS ........................................................................................................................ 289 2.25. PharmaZell ............................................................................................................... 300 2.26. SAFC ........................................................................................................................ 304 2.27. Saltigo (Lanxess) ...................................................................................................... 317 2.28. Shasun ...................................................................................................................... 334 2.29. Siegfried .................................................................................................................... 338 2.30. Sumitomo .................................................................................................................. 350 2.31. Tessenderlo .............................................................................................................. 360 2.32. Vertellus .................................................................................................................... 372 2.33. Wacker ...................................................................................................................... 380 2.34. WeylChem ................................................................................................................ 391 2.35. ZaCh System ............................................................................................................ 400

B. Historic Data ...................................................................................................................... 404

The Fine Chemical Benchmarking Service – Part 2 Historic data


404

B. Historic data

Contents B. Historic data ...................................................................................................................... 404 3. Historic data 1999 – 2012 – First half ................................................................................ 406

3.1. The leading fine chemical companies in 2012 – first half .......................................... 407 3.2. The leading fine chemical companies in 2011 – full year .......................................... 420 3.3. The leading fine chemical companies in 2011 – first half .......................................... 433 3.4. The leading fine chemical companies in 2010 – full year .......................................... 446 3.5. The leading fine chemical companies in 2010 – first half .......................................... 458 3.6. The leading fine chemical companies in 2009 – full year .......................................... 470 3.7. The leading fine chemical companies in 2009 – first half .......................................... 482 3.8. The leading fine chemical companies in 2008 – full year .......................................... 494 3.9. The leading fine chemical companies in 2007 – full year .......................................... 506 3.10. The leading fine chemical companies in 2007 – first half ......................................... 518 3.11. The leading fine chemical companies in 2006 – full year ......................................... 530 3.12. The leading fine chemical companies in 2006 – first half ......................................... 541 3.13. The leading fine chemical companies in 2005 – full year ......................................... 552 3.14. The leading fine chemical companies in 2005 – first half ......................................... 562 3.15. The leading fine chemical companies in 2004 – full year ......................................... 572 3.16. The leading fine chemical companies in 2004 – first half ......................................... 582 3.17. The leading fine chemical companies in 2003 – full year ......................................... 592 3.18. The leading fine chemical companies in 2003 – first half ......................................... 602 3.19. The leading fine chemical companies in 2002 – full year ......................................... 612 3.20. The leading fine chemical companies in 2002 – first half ......................................... 622 3.21. The leading fine chemical companies in 2001 – full year ......................................... 631 3.22. The leading fine chemical companies in 2001 – first half ......................................... 640 3.23. The leading fine chemical companies in 2000 – full year ......................................... 646 3.24. The leading fine chemical companies in 2000 – first half ......................................... 651 3.25. The leading fine chemical companies in 1999 – full year ......................................... 657 3.26. Profitability of the leading companies since 2000 .................................................... 662

3.26.1. Profitability in 2012 – first half ............................................................................ 662 3.26.2. Profitability in 2011 – full year ............................................................................ 664 3.26.3. Profitability in 2010 – full year ............................................................................ 666 3.26.4. Profitability in 2009 – full year ............................................................................ 668 3.26.5. Profitability in 2009 – first half ............................................................................ 670 3.26.6. Profitability in 2008 – full year ............................................................................ 672 3.26.7. Profitability in 2007 – full year ............................................................................ 674 3.26.8. Profitability in 2007 – first half ............................................................................ 676 3.26.9. Profitability in 2006 – full year ............................................................................ 678 3.26.10. Profitability in 2006 – first half .......................................................................... 680

The Fine Chemical Benchmarking Service – Part 2 Historic data


405

3.26.11. Profitability in 2005 – full year .......................................................................... 682 3.26.12. Profitability in 2005 – first half .......................................................................... 684 3.26.13. Profitability in 2004 – full year .......................................................................... 686 3.26.14. Profitability in 2004 – first half .......................................................................... 688 3.26.15. Profitability in 2003 – full year .......................................................................... 690 3.26.16. Profitability in 2003 – first half .......................................................................... 692 3.26.17. Profitability in 2002 – full year .......................................................................... 693 3.26.18. Profitability in 2002 – first half .......................................................................... 694 3.26.19. Profitability in 2001 – full year .......................................................................... 695 3.26.20. Profitability in 2001 – first half .......................................................................... 696 3.26.21. Profitability in 2000 – full year .......................................................................... 697 3.26.22. Profitability in 2000 – first half .......................................................................... 698

3.27. Profiles of acquired / previously listed companies .................................................... 699

3.27.1. Air Products and Chemicals .............................................................................. 700 3.27.2. Archimica (i.e. BTP’s fine chemicals) ................................................................ 707 3.27.3. Ascot plc ............................................................................................................ 709 3.27.4. Avecia ................................................................................................................ 713 3.27.5. C6 Solutions ...................................................................................................... 722 3.27.6. ChemFirst Fine Chemicals ................................................................................ 726 3.27.7. Chirex (Rhodia – ChiRex) .................................................................................. 729 2.27.8. CU Uetikon ........................................................................................................ 732 3.27.9. Eastman Chemical............................................................................................. 743 3.27.10. Finorga ............................................................................................................. 751 3.27.11. Great Lakes ..................................................................................................... 754 3.27.12. KemFine .......................................................................................................... 759 3.27.13. Laporte ............................................................................................................. 770 3.27.14. Orgasynth ........................................................................................................ 774 3.27.15. Oxychem .......................................................................................................... 781 3.27.16. PPG Fine Chemicals ....................................................................................... 782 3.27.17. Raschig ............................................................................................................ 790 3.27.18. Rhodia ............................................................................................................. 795 3.27.19. Rutherford Chemicals ...................................................................................... 812 3.27.20. SKW Trostberg ................................................................................................ 816 2.27.21. Yule Catto ........................................................................................................ 818


Part 3

The Fine Chemical Family Tree

November 2012

JR


JR



Jan Ramakers Fine Chemical Consulting Group November 2012

1

Contents 1. Introduction .......................................................................................................3 2. Major acquisition chains ....................................................................................4

2.1. Clariant ............................................................................................................................5 2.2. Cambrex ...........................................................................................................................6 2.3. Dow ..................................................................................................................................7 2.4. DSM .................................................................................................................................8 2.5. Evonik (Degussa) ..............................................................................................................9 2.6. Rhodia (now Solvay) ..................................................................................................... 10

3. Corporate activity per company ....................................................................... 11

3.1. Aesica ............................................................................................................................ 12 3.2. Air Products and Chemicals .......................................................................................... 14 3.3. Albemarle ..................................................................................................................... 15 3.4. Ampac Fine Chemicals .................................................................................................. 17 3.5. Archimica ...................................................................................................................... 19 3.6. Ascot ............................................................................................................................. 20 3.7. Arkema ......................................................................................................................... 21 3.8. Avecia Fine Chemicals .................................................................................................. 22 3.9. BASF .............................................................................................................................. 25 3.10. Borregaard Synthesis .................................................................................................. 28 3.11. BTP .............................................................................................................................. 30 3.12. C6 Solutions (formerly Hickson) ................................................................................. 31 3.13. CABB (formerly SF-Chem) ........................................................................................... 32 3.14. Cambrex ...................................................................................................................... 33 3.15. ChemFirst Fine Chemicals ........................................................................................... 37 3.16. Chemetall.................................................................................................................... 38 3.17. ChiRex (Rhodia – ChiRex) ............................................................................................ 39 3.18. Clariant ....................................................................................................................... 40 3.19. Contract Chemicals ..................................................................................................... 44 3.20. CU Chemie Uetikon .................................................................................................... 45 3.21. Dottikon ...................................................................................................................... 46 3.22. Dow ............................................................................................................................. 47 3.23. DSM ............................................................................................................................ 49 3.24. Eastman Chemical ...................................................................................................... 55 3.25. Evonik ......................................................................................................................... 56



2

3.26. Finorga ........................................................................................................................ 63 3.27. Great Lakes ................................................................................................................. 64 3.28. Honeywell ................................................................................................................... 65 3.29. Inspec .......................................................................................................................... 67 3.30. Isochem ...................................................................................................................... 68 3.31. ISP ............................................................................................................................... 70 3.32. KemFine ...................................................................................................................... 71 3.33. Koei Chemical ............................................................................................................. 72 3.34. Laporte ....................................................................................................................... 73 3.35. Lonza ........................................................................................................................... 74 3.36. Novasep ...................................................................................................................... 82 3.37. Omnichem .................................................................................................................. 84 3.38. Orgamol ...................................................................................................................... 85 3.39. Orgasynth ................................................................................................................... 86 3.40. PCAS ............................................................................................................................ 88 3.41. PharmaZell .................................................................................................................. 90 3.42. PPG Fine Chemicals .................................................................................................... 91 3.43. Procos ......................................................................................................................... 92 3.44. Rhodia ......................................................................................................................... 93 3.45. Saltigo (Lanxess) ......................................................................................................... 98 3.46. Shasun ...................................................................................................................... 101 3.47. Siegfried .................................................................................................................... 102 3.48. Sigma-Aldrich (SAFC) ................................................................................................ 104 3.49. SKW Trostberg .......................................................................................................... 108 3.50. Sumitomo ................................................................................................................. 109 3.51. Tessenderlo .............................................................................................................. 110 3.52. Vertellus .................................................................................................................... 113 3.53. Wacker ...................................................................................................................... 115 3.54. WeylChem ................................................................................................................ 117 3.55. Yule Catto ................................................................................................................. 120 3.56. ZaCh System ............................................................................................................. 122

Index of all companies ....................................................................................... 123



123

Index of all companies

3

3i Group .................................................... 75

A

Abbott ...................................................... 12 Abbott Laboratories .................................... 26 ACF Chemie ............................................... 52 Acordis Fine Chemicals ............................. 114 Adrian Group ............................................. 90 Aerojet Fine Chemicals ............................... 17 Aesica ....................................................... 12 Agroferm ................................................... 63 Air Products and Chemicals ......................... 14 Akzo Nobel ........................................... 15, 49 Albemarle .....................15, 21, 39, 55, 98, 121 Albright & Wilson ....................................... 97 Algonomics ................................................ 83 All'Chem .................................................... 91 Allco ......................................................... 71 Allied Signal .......................................... 69, 71 Alpha Bioverfahrenstechnik ....................... 106 Alpha Drug India ........................................ 52 Altana ....................................................... 40 AlzChem .................................................... 66 AlzChem Trostberg ..................................... 65 American Pacific Corporation ....................... 17 Ampac Fine Chemicals ......................... 17, 126 Angus Chemical Company ........................... 49 Arch Chemicals ..................................... 24, 85 Archimica ................................. 19, 31, 42, 44 Archport .................................................... 47 Argos Soditic ............................................. 91 Ariel Research Corporation .......................... 58 ARK Scientific GmbH Biosystems ............... 108 Arkema ..................................................... 21 Armour Polymers Ltd ................................ 117 Arques Industries ....................................... 87 Arsenal Capital Partners ............................ 117 Ascot ............................................. 20, 49, 50 Ashland ..................................................... 64 Asta Medica ............................................... 60 AstraZeneca .............................................. 55 AstraZeneca Specialties .............................. 22 Atofina ......................................... 15, 21, 114 Auctus Capital Partners ............................... 94 Aurelius.......................................... 33, 73, 75 Avecia ............................................ 23, 54, 75 Avecia Fine Chemicals ................................ 22 Aventis ............................................... 92, 102 Avesta Biotherapeutics and Research ......... 106 AWD Pharma ............................................. 60

Axyntis ...................................................... 91 AZ Electronic Materials ................................ 44

B

Barclays Private Equity ............................... 47 BASF .............................................. 12, 26, 89 Bayer ................................................. 72, 102 Bayer CropScience AG .............................. 102 Beijing Albemarle Yanshan Fine Chemical

Company ............................................... 15 Bio Science Contract Production .................. 35 Bio*One Capital ......................................... 81 BioCatalytics .............................................. 74 Biocompatibles ........................................... 34 BioWhittaker .............................................. 34 Bitterfeld Wolfen ...................................... 123 bluO ......................................................... 66 BMS .......................................................... 52 Boehringer Ingelheim ................................. 34 Boehringer Ingelheim Bioprod Partnership .... 34 Boots Pharmaceuticals ................................ 12 Borregaard Synthesis .................................. 29 Borregaard Taicang Chemicals..................... 30 Borsodchem .............................................. 72 Boston BioSystems ..................................... 22 BP Antwerp ............................................... 71 BP Barry .................................................... 71 Bridgepoint ................................................ 33 BTP..................................................... 31, 42

C

C6 Solutions .............................................. 32 CABB ........................................................ 33 CABB OY ................................................... 75 CalaChem ............................................ 33, 75 Calaire .................................................... 115 California Peptide Research ......................... 84 Cambrex ................................ 34, 36, 81, 122 Cambrex Zenara ........................................ 37 Camlin Fine Chemicals ................................ 30 Capvis ....................................................... 33 CarboTech ............................................... 121 CasChem ................................................... 35 Catalytica Pharmaceuticals .......................... 52 Cauldron ................................................... 41 CBC Group................................................. 96 Celanese ................................................... 14 Celanese AG .............................................. 42 Celgene ..................................................... 34 Celltech ..................................................... 79 Celltech Biologics ....................................... 78



124

Central Romana ......................................... 68 Chelsea Building Products ......................... 115 Chemetall .................................................. 40 ChemFirst Fine Chemicals ...................... 15, 39 Chemie Linz ............................................... 52 Chemiesynth Group .................................. 124 Chiragene ................................................. 34 Chiralix ..................................................... 54 ChiRex ................................................. 41, 97 Chirosep.................................................... 91 ChiroTech ............................................. 20, 50 Chloralp .................................................... 99 Ciba .......................................................... 27 Cinven ...................................................... 22 Clariant ............................. 19, 31, 33, 42, 124 Clariant Acetyl Building Blocks ................ 33, 44 Clariant Pharmaceutical Fine Chemicals ........ 44 Clariant’s Custom Manufacturing Business ... 45,

122 CoEBio3 .................................................... 27 Cognis ...................................................... 28 Colour-Chem ............................................. 43 Conti BPC .................................................. 34 Contract Chemicals .................................... 46 Corden Pharma ........................................ 116 Cosan Chemical Corporation ....................... 35 Creapharm ................................................ 92 CU Chemie Uetikon .................................... 47 Cyanamid .................................................. 26 Cyprus Foote ............................................. 40 Cytec ........................................................ 77

D

Dalton Pharma Services .............................. 84 DanChem .................................................. 32 Danisco ................................................ 58, 99 Degussa ....................................... 60, 61, 117 Degussa Sanzheng (Yingkou) Fine Chemicals 64 Degussa-Hüls ..................................... 60, 112 Dentsply International ................................ 60 Deretil ....................................................... 52 Dipharma .................................................. 77 Diversa Corporation.................................... 49 dmc2 ........................................................ 61 Dottikon .................................................... 48 Dow Chemical ................................. 20, 49, 72 Dowpharma ............................................... 50 Dr Reddy’s ................................................ 50 DSM .................................................... 24, 52 DSM Agro .................................................. 56 DSM Anti-infectives .................................... 55 DSM Anti-Infectives .................................... 57 DSM Biologics ....................................... 52, 56 DSM Catalytica Pharmaceuticals .................. 52 DSM Deretil ............................................... 56 DSM Elastomers ......................................... 57 DSM Melamine ........................................... 56 DSM Minera ............................................... 55

DSM Pharma Products ................................ 54 DSM Pharmaceutical Products ..................... 16 DSM Sinochem Pharmaceuticals .................. 57 DSM Special Products ................................. 56 DuPont Crop Protection ............................ 115 Durate Pharmaceutica .............................. 124 Dynamic Synthesis ..................................... 86 Dynamit Nobel ................................ 40, 67, 86 DyStar ....................................... 27, 103, 123

E

E.On ......................................................... 60 Eastman Chemical ...................................... 58 Eastman Peboc .................................... 58, 59 Elf Atochem ............................................... 21 EMS Dottikon ............................................. 48 Enichem .................................................. 114 Epichem Group ........................................ 109 Equateq .................................................... 28 Ergon Capital Partners ................................ 94 Erie Chem ............................................... 124 Erredue SpA .............................................. 19 Euticals ............................................... 19, 42 Evonik ................................................. 60, 65 Evonik Energy ............................................ 66 Evonik Rexim ............................................. 66 Excelsyn Molecular Development ................. 68 Expansia ................................................... 92

F

Farmabios ................................................. 94 Feralco ...................................................... 99 Fine Organics Ltd ....................................... 65 Finorga ............................................... 67, 86 Floressence ............................................... 90 FMC's bioproducts business ......................... 34 Framochem ......................................... 72, 73 Francis ...................................................... 77

G

Ganes ..................................................... 106 GEA Pharmaceutical ................................... 94 Gencorp .................................................... 17 Genencor .................................................. 58 Genencor International ............................... 98 Genentech ........................................... 79, 81 General Electric .......................................... 69 Genolife .................................................... 36 Genzyme Transgenics ................................. 78 Gilead ....................................................... 65 Gist Brocades ............................................. 52 Glaxo Wellcome ......................................... 41 Granules India ........................................... 88



125

Granules OmniChem .................................. 88 Great Lakes ............................................... 68 Gulf Bayport Chemicals ............................... 79

H

Haltermann .......................................... 20, 49 Hampshire Chemical Corp ........................... 49 Harlow Chemical Company (Harco) ............ 124 Heico Chemicals ......................................... 35 Henogen ................................................... 87 Heubach ................................................... 23 Hexachimie ............................................... 31 Hexal Synthese .......................................... 63 Hickson International ................................. 32 Hickson PharmaChem ................................. 32 Hoechst .................................................. 119 Hoechst Fine Chemicals .............................. 42 Holland Sweetener Company....................... 55 Holliday Chemical Holdings ....................... 124 Holliday Dyes & Chemicals ........................ 124 Honeywell ................................................. 69 Honeywell Research & Life Science Solutions 69 Huntsman Corporation ............................... 97 Hybridon ................................................... 22

I

Ian Shott Development ............................... 68 IBC Advanced Technologies ........................ 23 ICI ............................................................ 14 ICIG ........................ 16, 36, 45, 116, 121, 122 IEP GmbH ................................................. 37 Ilypsa ..................................................... 103 Imitech ..................................................... 71 INEOS Chlor .............................................. 99 INEOS ChlorVinyls .................................... 115 Inspec ................................................. 71, 77 Inspec Mining Chemicals ............................. 77 Intergreen ................................................. 29 International Chemical Investors Group ..... 116 Investcorp ................................................. 22 Iropharm ............................................ 69, 109 Irotec ....................................................... 34 Isochem ......................................... 72, 73, 75 Isola ....................................................... 121 ISP ........................................................... 74

J

James Robinson India .............................. 124 Janssen Pharmaceutica ............................. 122 Jayhawk Fine Chemicals ........................ 61, 71 Johnson Matthey ................................... 43, 69 Jordan Bromine Company ........................... 15 Jordan Dead Sea Industries Company .......... 15

JRH Biosciences ....................................... 108 Jülich Fine Chemicals ................................ 119

K

Kemetyl ..................................................... 29 KemFine ......................................... 25, 33, 75 KemFine Finland ........................................ 75 KemFine UK ......................................... 73, 75 Kemira ......................................... 75, 98, 103 Kerling UK ............................................... 115 Knoll ......................................................... 26 Koei Chemical ............................................ 76 Kyowa Hakko ............................................. 63

L

Laboratorios Julián de México .................... 124 Lancaster Synthesis .................................... 43 Lanxess .............................................. 57, 102 Laporte .................................... 60, 61, 71, 77 Leiras Fine Chemicals ................................. 92 Lenzing ..................................................... 71 Lonza .................................................. 37, 78 Lonza Biotec .............................................. 79 Lubrizol Corporation ................................... 24 LumiTech .................................................. 34 Lynchem ................................................... 64

M

Marathon Biopharmaceuticals ...................... 35 McLaughlin Gormley King Company ........... 118 Merck ............................................. 25, 27, 90 Merck Sharp & Dohme ................................ 12 MG Technologies .................................. 40, 86 Microbia .................................................... 57 Mitchell Cotts ....................................... 20, 50 Miteni...................................................... 122 Mitovie Pharma .......................................... 13 Mitsui ...................................................... 113 Molecular Medicine BioServices .................. 109 Monsanto ............................................ 68, 75

N

Nactis ..................................................... 114 Nanosyn .................................................... 93 Nantong Acetic Acid Chemical Corporation .. 118 Nantong Reilly Chemical Corporation .......... 118 NeoMPS .................................................... 73 NeoResins ................................................. 54 Nepera ................................................ 34, 35 NETDA .................................................... 107 NextPharma Technologies ........................... 17



126

Nicholas Piramal ........................................ 99 Nobel Explosifs .......................................... 73 North China Pharmaceutical Corporation ...... 55 Novacap .................................................. 101 Novartis .................................................... 83 Novasep ............................................... 86, 99 Noveon ..................................................... 94 Novochem ............................................... 102 NSC Technologies ...................................... 68 Nufarm ..................................................... 27 Nutrinova .................................................. 80 Nylstar .................................................... 100

O

OM Group ................................................. 61 Omnichem ................................................. 88 Orascom Construction Industries ................. 56 Orelis ........................................................ 99 Orgachim .................................................. 91 Orgamol ............................................... 27, 89 Orgapharm ........................................... 90, 91 Orgasynth ................................................. 90 Orkla ........................................................ 29 Otsuka Chemical ........................................ 30 Oxon ........................................................ 60 Oxxynova ............................................. 60, 65

P

Palmer Research ........................................ 68 PCAS ........................................................ 92 PCAS Biosolution ........................................ 93 PCAS-Nanosyn ........................................... 93 PCR .......................................................... 31 Pemco ...................................................... 29 Penick ..................................................... 106 Penn Specialty Chemicals ............................ 68 Pentagon Chemicals ................................... 68 Perstorp .................................................... 82 Pharmaceutical Fine Chemicals .................... 69 Pharmaceutical Fine Chemicals Sarl ............. 69 Pharmaceutical Resources........................... 74 PharmaChem Technologies ......................... 87 Pharmacie Centrale de France ..................... 92 PharmaZell ................................................ 94 Pharmophix ............................................. 110 Pharmorphix ............................................ 109 Phillips Petroleum....................................... 49 Phoenix Chemicals ................................... 105 Pliva ......................................................... 60 Polaroid’s fine chemicals ............................. 74 PolyCarbon Industries ................................ 29 Polynt ....................................................... 81 Polynt SpA................................................. 82 PolyOrganics ............................................. 29 PolyPeptide ............................................... 73 PPG ........................................................ 126

PPG Fine Chemicals .................................... 95 PPG-Sipsy ................................................ 126 ProBioSint ................................................. 42 Procos ....................................................... 96 Prokaria .................................................. 119 Proligo ......................................... 62, 63, 109 ProSyntest ................................................. 37 Protéus ..................................................... 93 Puragen .................................................... 23 Pyrion ..................................................... 122

Q

Quality Chemicals ....................................... 39

R

R5 Pharmaceuticals .................................... 12 RAG .......................................................... 65 Raschig ..................................................... 62 Raylo ........................................................ 65 Raylo Chemicals ......................................... 61 Reilly.................................................. 62, 117 Rescom ..................................................... 54 Rexim ....................................................... 66 Rhodia ........................................... 41, 46, 97 Rhodia – ChiRex ......................................... 41 Rhodia Pharma Solutions .......................... 105 Rhône-Poulenc ........................................... 97 Rhône-Poulenc Rorer .................................. 97 Riedel de Haen .......................................... 69 Roche ................................................. 31, 53 Rohm and Haas ......................................... 51 Rohm and Haas Advanced Biosciences ......... 86 Rohner ................................................ 86, 87 Rutger’s Speciality Surfactants ................... 121 Rutgers Organics...................................... 121 Rütgers Organics...................................... 121 Rutherford Chemicals .................... 35, 36, 117

S

Sabic ......................................................... 53 Sachem ..................................................... 61 SAFC ........................................ 108, 109, 110 Salsbury .................................................... 34 Saltigo ............................................. 102, 103 Sandoz ................................................ 42, 94 Sanofi ................................................. 67, 77 Sanofi-Aventis .......................................... 107 Sanofi-Synthélabo ................................ 67, 86 Säurefabrik Schweizerhall ........................... 33 Schenectady .............................................. 77 Schering .................................................... 92 Schwarz Pharma ........................................ 92 Seal Sands Chemicals ................................. 35



127

Seibu Kasei Co ......................................... 113 Seloc France .............................................. 92 Sentrachem ............................................... 49 Seres ........................................................ 93 SF-Chem .............................................. 33, 44 Shanghai SNPE Chemicals ........................... 72 Shasun.................................................... 105 Shasun Chemicals & Drugs ....................... 100 Shell Fine Chemicals ................................... 71 Shin-Etsu Chemical .................................... 43 Shire Pharmaceutical .................................. 56 Shuangling Chemical Industry ................... 114 Sidroga ................................................... 106 Siegfried ................................................. 106 Sigma-Aldrich ..................................... 70, 108 Sinochem .................................................. 57 Sipsy......................................................... 95 Sisas ......................................................... 26 Sissa ......................................................... 73 SKW Trostberg ................................... 60, 112 Snecma ..................................................... 72 SNPE ...................................... 49, 72, 75, 114 Société Béarnaise de Synthèse .................... 92 Solvay ................................................ 10, 101 Stahl ......................................................... 23 Sumika Fine Chemicals ............................. 113 Sumika-Takeda Agro Manufacturing Co ...... 113 Sumitomo ............................................... 113 Suven Life Sciences .................................... 29 Symyx Technologies ................................... 49 Syncom ..................................................... 54 Syngenta ...................................... 33, 44, 104 Synopharm .............................................. 106 Syntex Agribusiness ................................... 31 Syntex Pharmaceuticals .............................. 87 Synthélabo ................................................ 67 Synthetics International AG ....................... 125 Synthetics-Uquifa AG ................................ 125 Synthexim ................................................. 91 Synthon Chiragenics ................................... 34 Synthon Chiragenics Corporation ................. 23

T

Taile ....................................................... 114 Taile Chemical Industry ............................ 114 Takeda’s vitamin business ........................... 26 Tallin University of Technology .................... 37 Taminco .................................................... 14 Tennants ................................................. 115 Tessenderlo .................................. 21, 73, 114 Tessenderlo Fine Chemicals Limited ........... 115 Tessenderlo Kerley ................................... 115 Tetrionics ................................................ 108 Teva .................................................... 19, 83 Teva Pharmaceuticals ................................. 69 Th.Goldschmidt ........................................ 112 Tillotts Pharma .......................................... 38 Topigen Pharmaceuticals ............................ 50

Torcan ...................................................... 22 Tosoh Corporatio ....................................... 55 TotalFinaElf ............................................... 21 Towerbrook Capital Partners ................. 19, 44

U

UCB .................................................... 13, 80 UCB-Bioproducts ........................................ 81 Ultrafine .................................................. 108 Union Carbide ............................................ 49 Uquifa ..................................................... 124

V

VanDeMark Chemical .................................. 73 Vapi Products Industries ........................... 118 Veba ......................................................... 60 Velsicol...................................................... 56 Vertellus .................................................. 117 Vertellus Specialty Materials (India) ........... 118 Viag ................................................... 60, 112 Vivante GMP Solutions ................................ 84 VLG Chem ................................................. 92 Voridian Company ...................................... 58

W

Wacker ................................................... 119 Wacker Fine Chemicals ............................. 120 Warner-Lambert ......................................... 32 Weifang Yaxing Chemical Company ........... 103 Weyl ....................................................... 121 WeylChem ............................. 16, 36, 116, 121 Wind Point Partners .................................. 117

Y

Yule Catto ............................................... 124

Z

Zach System .............................................. 17 ZaCh System ...................................... 95, 126 Zaltbommel ............................................... 61 Zambon .................................................... 95 Zeeland Chemicals ..................................... 35 ZellBios ..................................................... 94 Zenara Pharma .......................................... 37 Zeneca .................................................... 117 Zeneca LSM ............................................... 22 Zentiva .................................................... 107 Zeria Pharmaceutical .................................. 38


Part 4

The non-pharma Fine Chemical Industry

- Current Status and Trends -

August 2012

JR


JR


The Fine Chemical Benchmarking Service Part 4 – non-pharma markets

Jan Ramakers Fine Chemical Consulting Group August 2012

3

Contents

1. The chemical industry .............................................................................................................4

1.1. Industry structure .............................................................................................................4 1.2. Fine Chemicals & performance chemicals ......................................................................4 1.3. Non-pharma fine chemical market segments ..................................................................7

2. Detail information for each non-pharma segment ............................................................... 11

2.1. Agrochemicals .............................................................................................................. 11 2.2. Antioxidants .................................................................................................................. 16 2.3. Biocides ........................................................................................................................ 17 2.4. Cosmeceuticals ............................................................................................................ 20 2.5. Cosmetics & Toiletries (C&T) ....................................................................................... 21 2.6. Electronic chemicals ..................................................................................................... 24 2.7. Flavours & Fragrances (F&F) ....................................................................................... 27 2.8. Food additives .............................................................................................................. 29 2.9. Nutraceuticals ............................................................................................................... 31 2.10. Photographic chemicals ............................................................................................. 32 2.11. Organic Pigments and Dyes ....................................................................................... 33 2.12. Plastics additives ........................................................................................................ 34 2.13. Rubber processing chemicals .................................................................................... 36

Documents

The Fine Chemical Benchmarking Service - Contents pages Fine Chemical...The Fine Chemical Benchmarking Service . Part 1 . The Pharmaceutical Fine Chemical Industry - Current Status