The AllergyEpidemic

Do you suffer from:

Weight Gain? 1 2 3 4

Fatigue? 5 6 7 8 9

Depression? 10 11 12

Headaches? 13 14 15 16

Insomnia? 17 18

Stomach Aches? 19 20

Brain Fog? 21

Allergiescould be

the culprit

1. Childhood overweight/obesity and asthma: is there a link? A systematic review of recent epidemiologic evidence. Papoutsakis C, Priftis KN, Drakouli M, Prifti S, Konstantaki E, Chondronikola M, Antonogeorgos G, Matziou V. J Acad Nutr Diet. 2013 Jan;113(1):77-105.

2. Mast cell stabilization: novel medication for obesity and diabetes. Wang J, Shi GP. Diabetes Metab Res Rev. 2011 Nov;27(8):919-24. Mice fed a Western diet were able to reduce obesity through treatment with anti-allergic drugs that stabilize mast cells (cromolyn and ketotifen).

3. Adipokines and their role in allergies. Ciprandi G, Caimmi D, Raschetti R, Miraglia Del Giudice M, Salpietro C, Caimmi S, Castellazzi AM. Int J Immunopathol Pharmacol. 2011 Oct;24(4 Suppl):136.

4. Asthma and obesity: common early-life influences in the inception of disease. Litonjua AA, Gold DR. J Allergy Clin Immunol. 2008 May;121(5):1075-84

5. Systemic manifestations due to allergy. Report of fifty patients and a review of the literature on the subject (sometimes referred to as allergic toxemia and the allergic tension-fatigue syndrome). CROOK WG, HARRISON WW, CRAWFORD SE, EMERSON BS.

6. Pediatrics. 1961 May;27:790-9.The allergic tension-fatigue syndrome. Young EJ. Calif Med. 1970 Jun;112(6):46.

7. Allergic tension-fatigue syndrome. Weinberg EG, Tuchinda M. Ann Allergy. 1973 Apr;31(4):209-11

8. In vitro response of lymphocytes in patients with allergic tension-fatigue syndrome. Valverde E, Vich JM, Garcia-Calderon JV, Garcia-Calderon PA. Ann Allergy. 1980 Sep;45(3):185-8

9. Proliferative responses of lymphocytes to food antigens are useful for detection of allergens in nonimmediate types of food allergy. Kondo N, Fukutomi O, Agata H, Yokoyama Y. J Investig Allergol Clin Immunol. 1997 Mar-Apr;7(2):122-6

10. Higher risk of developing major depression and bipolar disorder in later life among adolescents with asthma: a nationwide prospective study. Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, Chen TJ, Bai YM. J Psychiatr Res. 2014 Feb;49:25-30

11. Impact of allergy treatment on the association between allergies and mood and anxiety in a population sample. Goodwin RD, Galea S, Perzanowski M, Jacobi F. Clin Exp Allergy. 2012 Dec;42(12):1765-71.

12. Can allergic exposure provoke psychological symptoms? A double-blind test. King DS. Biol Psychiatry. 1981 Jan;16(1):3-19.

13. Food allergy and headache. Whom to evaluate and how to treat. Mansfield LE. Postgrad Med. 1988 May 15;83(7):46-51, 55.

14. Is food allergy giving me a headache? Alam R. Immunol Allergy Clin North Am. 2012 Feb;32(1):xiii-xiv.

15. Allergy and immunotherapy: are they related to migraine headache?Martin VT, Taylor F, Gebhardt B, Tomaszewski M, Ellison JS, Martin GV, Levin L, Al-Shaikh E, Nicolas J, Bernstein JA. Headache. 2011 Jan;51(1):8-20.

16. Nonmigrainous headache from food allergy. Stefanini GF, Marsigli L, Foschi FG, Emiliani F, Biselli M, Caputo F, Leefield GH, Castelli E, Gasbarrini G. Allergy. 1996 Sep;51(9):657-8.

17. Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA(2)LEN survey. Sundbom F, Lindberg E, Bjerg A, Forsberg B, Franklin K, Gunnbjörnsdottir M, Middelveld R, Torén K, Janson C. Allergy. 2013 Feb;68(2):213-9.

18. Increased sleep latency and reduced sleep duration in children with asthma. Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG. Sleep Breath. 2013 Mar;17(1):281-7.

19. Recurrent abdominal pain, food allergy and endoscopy. Husby S, Høost A. Acta Paediatr. 2001 Jan;90(1):3-4.

20. Int Arch Allergy Immunol. 2006;140(4):334-41. Measurements of eosinophil activation before and after food challenges in adults with food hypersensitivity. van Odijk J1, Peterson CG, Ahlstedt S, Bengtsson U, Borres MP, Hulthén L, Magnusson J, Hansson T.

21. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. Skoner DP. J Allergy Clin Immunol. 2001 Jul;108(1 Suppl):S2-8.

We have entered

The Age of Allergies

Over 1 Billion PeopleSuffer from Allergies

European Academy of Allergy and Clinical Immunology, ClinTransl Allergy. 2012; 2: 21.

300 MillionPeople have asthma around the world

Ann Allergy Asthmaaaa IIImmmunol. 20144 Feb;112(2)):108-15

Asthma is at Highest RateEver in the U.S.

Natl Health Stat Report. 2011 Jan 12;(32):1-14.Nurs Clin North Am. 2013 Mar;48(1):1-10

2 of 3 asthma cases are not controlled by their meds “Adequate Control” means• No restriction of activity

• Not waking at night with asthma

• Not needing bronchodilators more than 3 times a week

• Not missing school or work because of asthma

• Not having severe acute asthmatic reactions.

Asthma:

Out of Control

Every 2 Hours Someone in the U.S. Dies Of Asthma

These Lives Could Be Saved

I’d like to change the way you think

about allergy.

3Levels of Environment

that Matter

1. The Outdoor Environment

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2. The Indoor Environment

Amm J Respir Crit Care Med. 2007 Oct 15; 176(8): 735–777777777774444444441111111. TThhee UUUssseeeeee ooooooofffffff HHHHHHHooooouuuussehhhhhooooollllllddddd Cleaning Sprays and Adult Asthma, An IInnternational Longitudinnaall SStudy, JJaan-Paauul Zoocckkkkk aaaannnnnddddd cccccoooolllllleeeeaaaagggguues.Allergy Asthma Immunol Res. 2014 Nov;6(6):47888-88888444444.. ddddoi: 11000..44444411111111666666668888888///aair.2014...6666666.6666.478. Epub 2014 Oct 15. The effeccttss ooff eennvviironmmeenntal toxins on allerrggic inflammmatioonn. Yannggg SSSSNNNN aand coolllleaggguuuuees

3. The Internal Environment

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Fatigue

Out of Control

RagweedComing soon to a city near you!

J Allergy ClinImmunol. 2003 Feb;111(2):290-5. Cities as harbingers of climate change: common ragweed, urbanization, and public health. Ziska LH, Gebhard DE, Frenz DA, Faulkner S, Singer BD, Straka JG.

Rhinitison the Brain

Ann Allergy Asthma Immunol. 2002 Oct;89(4):372-80.J Investig Allergol Clin Immunol. 2009;19Suppl 1:32-9.

J Bras Pneumol. 2010 Jan-Feb;36(1):124-33

Brain AllergyInsomnia 1 2 3

Anxiety 4 5 6

Depression 7 8 9 10

Brain fog 11

Migraine headaches 12 Fibromyalgia and chronic fatigue 14

Attention deficit disorder 15

Autism 16

1. Pediatrics. 1985 Dec;76(6):880-4. Insomnia and cow's milk allergy in infants.Kahn A, Mozin MJ, Casimir G, Montauk L, Blum D.Sleep. 1987 Apr;10(2):116-21. Difficulty in initiating and maintaining sleep associated with cow's milk allergy in infants. Kahn A, Rebuffat E, Blum D, Casimir G, Duchateau J, Mozin MJ, Jost R.Pediatrics. 1989 Oct;84(4):595-603. Milk intolerance in children with persistent sleeplessness: a prospective double-blind crossover evaluation. Kahn A1, Mozin MJ, Rebuffat E, Sottiaux M, Muller MF.

2. Asthma symptoms and nasal congestion as independent risk factors for insomnia in a general population: results from the GA(2)LEN survey. Sundbom F, Lindberg E, Bjerg A, Forsberg B, Franklin K, Gunnbjörnsdottir M, Middelveld R, Torén K, Janson C. Allergy. 2013 Feb;68(2):213-9.

3. Increased sleep latency and reduced sleep duration in children with asthma. Jensen ME, Gibson PG, Collins CE, Hilton JM, Latham-Smith F, Wood LG. Sleep Breath. 2013 Mar;17(1):281-7.

4. Self-reported allergies and their relationship to several Axis I disorders in a community sample. Patten SB, Williams JV. Int J Psychiatry Med. 2007;37(1):11-22.NOTE: Although people with anxiety disorders are more likely to report a history of allergy, people with allergies are not more likely to report anxiety or psychological distress: Self-reported allergy-related symptoms and psychological morbidity in primary care. Euba R, Chalder T, Wallace P, Wright DJ, Wessely S. Int J Psychiatry Med. 1997;27(1):47-56.There are many ways to interpret this difference. One is that allergies contribute to psychological symptoms in some people( a sub-group of those who have psychological symptoms), but that people with allergies are not more prone to psychological symptoms in general.

5. Treatment-resistant depression: when antidepressant drug intolerance may indicate food intolerance. Parker G, Watkins T. Aust N Z J Psychiatry. 2002 Apr;36(2):263-5.

6. Self-reported allergies and their relationship to several Axis I disorders in a community sample. Patten SB, Williams JV. Int J Psychiatry Med. 2007;37(1):11-22.NOTE: Although people with anxiety disorders are more likely to report a history of allergy, people with allergies are not more likely to report anxiety or psychological distress: Self-reported allergy-related symptoms and psychological morbidity in primary care. Euba R, Chalder T, Wallace P, Wright DJ, Wessely S. Int J Psychiatry Med. 1997;27(1):47-56.There are many ways to interpret this difference. One is that allergies contribute to psychological symptoms in some people( a sub-group of those who have psychological symptoms), but that people with allergies are not more prone to psychological symptoms in general.

7. Treatment-resistant depression: when antidepressant drug intolerance may indicate food intolerance. Parker G, Watkins T. Aust N Z J Psychiatry. 2002 Apr;36(2):263-5.

8. Higher risk of developing major depression and bipolar disorder in later life among adolescents with asthma: a nationwide prospective study. Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, Chen TJ, Bai YM. J Psychiatr Res. 2014 Feb;49:25-30

9. Impact of allergy treatment on the association between allergies and mood and anxiety in a population sample. Goodwin RD, Galea S, Perzanowski M, Jacobi F.Clin Exp Allergy. 2012 Dec;42(12):1765-71.

10. Treatment-resistant depression: when antidepressant drug intolerance may indicate food intolerance. Parker G, Watkins T. Aust N Z J Psychiatry. 2002 Apr;36(2):263-5.

11. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis.Skoner DP. J Allergy Clin Immunol. 2001 Jul;108(1 Suppl):S2-8.

12. Randomised controlled trial of food elimination diet based on IgG antibodies for the prevention of migraine like headaches. Mitchell N, Hewitt CE, Jayakody S, Islam M, Adamson J, Watt I, Torgerson DJ. Nutr J. 2011 Aug 11;10:85. doi: 10.1186/1475-2891-10-85Diet restriction in migraine, based on IgG against foods: a clinical double-blind, randomised, cross-over trial. Alpay K, Ertas M, Orhan EK, Ustay DK, Lieners C, Baykan B. Cephalalgia. 2010 Jul;30(7):829-37Food allergy mediated by IgG antibodies associated with migraine in adults.Arroyave Hernández CM, Echavarría Pinto M, Hernández Montiel HL. Rev Alerg Mex. 2007 Sep-Oct;54(5):162-8.

13. [already cited] Are attention deficit hyperactivity disorder and chronic fatigue syndrome allergy related? what is fibromyalgia? Bellanti JA, Sabra A, Castro HJ, Chavez JR, Malka-Rais J, de Inocencio JM. Allergy Asthma Proc. 2005 Jan-Feb;26(1):19-28Functional bowel symptoms, fibromyalgia and fatigue: a food-induced triad?Berstad A, Undseth R, Lind R, Valeur J. Scand J Gastroenterol. 2012 Sep;47(8-9):914-9.

14. Allergy and the chronic fatigue syndrome.Straus SE, Dale JK, Wright R, Metcalfe DD. J Allergy Clin Immunol. 1988 May;81(5 Pt 1):791-5.Risk factors associated with chronic fatigue syndrome in a cluster of pediatric cases.Bell KM, Cookfair D, Bell DS, Reese P, Cooper L. Rev Infect Dis. 1991 Jan-Feb;13 Suppl 1:S32-8.

15. Association of childhood attention-deficit/hyperactivity disorder with atopic diseases and skin infections? A matched case-control study using the General Practice Research Database.Hak E, de Vries TW, Hoekstra PJ, Jick SS. Ann Allergy Asthma Immunol. 2013 Aug;111(2):102-106.e2Association between atopic diseases and attention-deficit/hyperactivity disorder in childhood: a population-based case-control study. Tsai JD, Chang SN, Mou CH, Sung FC, Lue KH. Ann Epidemiol. 2013 Apr;23(4):185-8.Association of atopic eczema and attention-deficit/hyperactivity disorder - meta-analysis of epidemiologic studies. Schmitt J, Apfelbacher C, Heinrich J, Weidinger S, Romanos M. Z Kinder Jugendpsychiatr Psychother. 2013 Jan;41(1):35-42Mental health comorbidity in patients with atopic dermatitis. Yaghmaie P, Koudelka CW, Simpson EL. J Allergy Clin Immunol. 2013 Feb;131(2):428-33Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study. Chen MH, Su TP, Chen YS, Hsu JW, Huang KL, Chang WH, Bai YM. J Child Psychol Psychiatry. 2013 May;54(5):545-51.

16. Am J Clin Dermatol. 2015 Oct;16(5):371-88. Association Between Atopic Dermatitis and Autism Spectrum Disorders: A Systematic Review. Billeci L1, Tonacci A1, Tartarisco G2, Ruta L2,3, Pioggia G4, Gangemi S5.J Psychosom Res. 2014 Oct;77(4):316-21. Is atopy in early childhood a risk factor for ADHD and ASD? a longitudinal study.Chen MH1, Su TP2, Chen YS1, Hsu JW1, Huang KL1, Chang WH1, Chen TJ3, Pan TL4, Bai YM5.

Pollen exposure impairs driving performance to the same extent as a blood alcohol level of 0.05 %, the same as having two alcoholic drinks.

Treatment of symptoms with antihistamines or nasal sprays partially—but not completely—blocks the impairment.Allergy. 2014 Jul;69(7):906-12

Driving under the influence of

Allergies

RhinitisRunaway

Affects 60 million people in the US and 500 million worldwide

Allergy Asthma Proc. 2010 ;31:365-9, Lancet. 2011 Dec 17;378(9809):2112-22

4Game-Changing Truths

About Allergies

1. Nutrition has a profound effect

2. Allergy is a great mimic

3. Detective work is needed to uncover hidden allergies

4. Your microbiome influences your immunity

When was the last time you

felt really well?

+

Office work exposures and adult-onset asthma.Jaakkola MS, Jaakkola JJ. Environ Health Perspect. 2007 Jul;115(7):1007-11Environ SciPollut Res Int. 2015 Apr;22(7):5241-52. Measurements of chlorinated volatile organic compounds emitted from office printers and photocopiers.Kowalska J1, Szewczyńska M, Pośniak M.

Do fast foods cause asthma, rhinoconjunctivitis and eczema? Global findings from the International Study of Asthma and Allergies in Childhood (ISAAC) phase three. Ellwood P, Asher MI, García-Marcos L, Williams H, Keil U,Robertson C, Nagel G; ISAAC Phase III Study Group. Thorax. 2013 Apr;68(4):351-60.

NutritionCan Help Balance Immunity

Fruits and Vegetablesvs.

Asthma

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Antioxidants play an important role

in asthmaAltern Med Rev. 2012 Mar;17(1):42-56.

Br J Nutr. 2010 Mar;103(5):735-4411.

Dietary flavonoid consumption is inversely associated with asthma incidence.

7 servings per day of vegetables and fruit can improve asthma

Am J Clin Nutr. 2002 Sep;76(3):560-8.Clinical trial (Am J Clin Nutr. 2012 Sep;96(3):534-43):

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Increased body fat is associated with increased prevalence of asthma, allergic rhinitis and eczema.

People with chronic allergic sinusitis are two and a half times more likely to be overweight than a control population without allergies.

EurRespir J. 2005 Feb;25(2):282-8; J Asthma. 2013 May;50(4):395-402; J Allergy ClinI mmunol. 2014 May;133(5):1308-14; Respir Med. 2006 Sep;100(9):1518-25; Br J Dermatol. 2012 Mar;166(3):498-504.Laryngoscope. 2014 Jul;124(7):1536-41.

Weight loss by itself improves asthma control among overweight

adults and children.

Clin Exp Allergy. 2001133 Jul;43(7))::7777555-88844.; Clin Exp Allergy. 2013 Jan;433(((1111))):36-49.

The hormone that fights

inflammation and allergies…

Adiponectin is an anti-inflammatory hormone produced by fat cells, but the larger the fat cells, the less adiponectin they make. Weight loss increases adiponectin.

Adiponectin has direct anti-allergic effects and reduces eosinophil activation.J Asthma. 2014 Jun;51(5):459-66. J Asthma. 2013 Oct;50(8):828-35.

AdiponectinParsley Enhances

J Agric Food Chem. 2014 Oct 29;62(43):10468-74; J Nutr Biochem. 2013 Aug;24(8):1547-54.

AdiponectinFood and Tea Flavonoids Boost

:202-8; Eur J Endocrinol. 2008 Oct;159(4):R5-10; Br J Nutr. 2013 Nov;110(10):1885-94. J Nutr. 2014 Feb;144(2):192-7. Rocz Panstw Zakl Hig. 2013;64(1):61-6. Obesity (Silver Spring). 2010 Aug;18(8):Nutrition. 2014 Feb;30(2):1

1632-7. Eur J Clin Nutr. 2010 Jun;64(6):614-21. Nutr Res. 2013 Dec;33(12):1012-8.

AdiponectinStrawberries Enhance

J Agric Food Chem. 2014 Oct 29;62(43):10468-74; J Nutr Biochem. 2013 Aug;24(8):1547-54.

Allergies &Weight Gain

A Vicious Cycle

Am J Physiol Cell Physiol. 2011 Dec;301(6):C1360-7.BMC Pulm Med. 2013 Jun 18;13:39.

ImpossibleAllergies to the foods you eat every day can make weight loss almost

AllergyEcologyNutrition

Protect Yourself from Mold:• Investigate and correct any sign of moisture accumulation,

in the basement, attic or living space, and leaks from any source.

• Do not carpet areas that are damp, like bathrooms

• Remove any material that harbors fungal growth –rotten food, old wood, furnishings have been damaged by water.

• Clean surfaces where mold regularly grows, especially shower stalls and curtains, with a non-toxic solution like hydrogen peroxide and water.

• Maintain a relative humidity of less than 50% in each room of your home, using a dehumidifier if necessary.

An unregulated antibacterial used in soaps, gels, toothpaste, clothing, cleaning solutions and medical equipment.

Higher levels of nasal triclosan are associated with greater Staph colonization.

Triclosan

MBio. 2014 Apr 8;5(2):e01015.

The Tangled Web ofChronic Rhinosinusitis

CRS affects 12.5% of people in the U.S. and is strongly associated with nasal polyps

Food allergy occurs in 70-80% of people with CRS-P

CRS-P is associated with heavy growth of Staph bacteria

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Ceellll Mol Immuunoll. 22001133;10((11):788--883

Superantigens from Staph Bacteria

Harm Immunity

Staph bacteria produce toxic superantigens that dysregulate immune responses and promote allergic sensitivity.

Swallowing Staph toxins increases your risk of developing allergies to the foods you eat.

Dietary flavonoids bind to and inhibit Staph toxins.J Immunol. 2014 Sep 15;193(6):2919-30; J Allergy ClinImmunol. 2004 Apr;113(4):756-63.Arch Dermatol Res. 2003 Sep;295(5):183-9; Cell Immunol. 2005 Sep;237(1):7-16; . J Agric Food Chem. 2010 May 12;58(9):5421-6; Food Chem Toxicol. 2014 Dec;74:1-8

Two thirdsof your immune system is located

in the lining of your intestines

Your Body is Like a Movable Rain

Forest

Eat RightFruits and vegetables, fermented foods, raw foods

OrganicEighty percent of the antibiotics used in this country are added to animal feed

They just encourage the growth of resistant organisms and impact negatively on healthy bacteria

Avoid Antibacterials

I recommend that you consult a doctor or nutritionist who’s experienced in their use

Probiotics

Your own health is closely connected to the world

around you.

Drill down into the science of allergy, immunity, nutrition, inflammation,

environmental health and the microbiome at:

down into the science of allnto the scienceity, nutrition, inflammrition,

mental healthobiom

DrGalland.com