We Nourish Hope

INVESTIGATIONand RESEARCHMedical Solutionsfor Childhood Diseases

We Nourish Hope

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FUNDACIÓ PRIVADA A. BOSCHPla de Begudà · 17857 St. Joan les Fonts · GironaTel.: +34 972 293 142www.fundacioabosch.org

Anna Bosch Güell,president of the A. BOSCH FOUNDATION

We nourish the hope of improving people’s wellbeing throughout their lives.

Anna Bosch Güell, president of the A. BOSCH FOUNDATION and managing director of NOEL ALIMENTARIA S.A.U.

A. BOSCH FOUNDATIONPRESENTATION

In 2004, NOEL ALIMENTARIA S.A.U., convinced of the need to encourage values in society, decided to establish the A . BOSCH F OUNDATION t o support projects of children’s medical research.

The company management founded this insti-tution in memory of its chief instigator, Albert Bosch Sala, f ather o f the c urrent m anaging director o f NOEL ALIMENTARIA S.A.U., Anna Bosch Güell.

The core area in which the Foundation works on a daily basis is research.

The A. BOSCH FOUNDATION is a not-for-profit institution governed b y Law 49/2002, o f 23 December 2002, based i n Sant J oan l es F onts (Girona) and presided by Anna Bosch Güell.

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

OUR MISSION

COMMITMENT TO SOCIETY

The A. BOSCH FOUNDATION works to encou-rage investigation and research into medical, biomedical and surgical solutions for childhood diseases and, more generally, to contribute to the people’s wellbeing throughout their lives.

The Foundation aspires to become a benchmark in translational research so that improvements made can be quickly applied in patients.

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

SCIENTIFIC TEAM

The scien tific team is formed by resea rch professionals from d ifferent s ections and depa rt me nt s of Vall d’Hebr on H ospital, Barcelona:

• Paediatric Oncology and Haematology Service.

• Foetal Surgery and Congenital Malformations Research Group. Bioengineering, Paediatric Orthopaedics and Surgery and Rehabilitation.

• Department of Internal Medicine, specialised in the treatment of autoimmune diseases.

These departments are chiefly responsible for the research work performed by the A. BOSCH FOUNDATION.

Team of the Oncology Biomedical Research Unit, Vall d’Hebron Hospital, Barcelona, led by Dr. Josep Sánchez de Toledo

Experimental Foetal Surgery Team, led by Dr. Ampar CuxartL upus Erythematosus Research Team, led by Dr. Josep Ordi Ros

We Nourish Hope

COLLABORATION and EXCHANGES

Through the Vall d’Hebron Hospital in Barcelona, the A. BOSCH FOUNDATION is involved with other similar institutions and has established systems of collaboration and exchange with European hospitals and universities.

It operates by awarding grants and subsidies for projects to develop and train postgraduates, by establishing collaboration agreements with universities and public or private institutions and by cooperating with other foundations.

INTERNATIONAL COLLABORATION

COLLABORATION IN SPAIN

Azienda Ospedaliera Università di Padova (Italy)

Bambino Gesù Ospedale Pediatrico, Roma (Italy)

Universität Zürich (Switzerland)

Universiteit van Amsterdam (Netherlands)

Royal College of Surgeons in Ireland

Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne (France)

The Children’s Hospital at Westmead (Australia)

Institut d’Investigació Biomèdica de Bellvitge, Barcelona

Instituto Universitario de Oncología del Principado de Asturias (IUOPA)

Instituto de Salud Carlos III, Madrid

Hospital Virgen del Rocío, Sevilla

Universitat de València

Instituto de Biomedicina y Biotecnología de Cantabria

RCSI

Bambino GesùOSPEDALE PEDIATRICO

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

We Nourish Hope

COLLABORATION and EXCHANGES

Through the Vall d’Hebron Hospital in Barcelona, the A. BOSCH FOUNDATION is involved with other similar institutions and has established systems of collaboration and exchange with European hospitals and universities.

It operates by awarding grants and subsidies for projects to develop and train postgraduates, by establishing collaboration agreements with universities and public or private institutions and by cooperating with other foundations.

INTERNATIONAL COLLABORATION

COLLABORATION IN SPAIN

Azienda Ospedaliera Università di Padova (Italy)

Bambino Gesù Ospedale Pediatrico, Roma (Italy)

Universität Zürich (Switzerland)

Universiteit van Amsterdam (Netherlands)

Royal College of Surgeons in Ireland

Institut de Pharmacologie Moléculaire et Cellulaire, Valbonne (France)

The Children’s Hospital at Westmead (Australia)

Institut d’Investigació Biomèdica de Bellvitge, Barcelona

Instituto Universitario de Oncología del Principado de Asturias (IUOPA)

Instituto de Salud Carlos III, Madrid

Hospital Virgen del Rocío, Sevilla

Universitat de València

Instituto de Biomedicina y Biotecnología de Cantabria

RCSI

Bambino GesùOSPEDALE PEDIATRICO

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

We Nourish Hope

LINE OF RESEARCH RESEARCH INTO CHILDREN’S CANCER Cancer in children is, fortunately, not very common (it accounts for 2% of all cancers) and treatment has a high (80%), albeit insufficient, success rate. The impact of the disease on children and their families is significant. Many tumours in children, such as rhabdomyosarcoma, neuroblastoma and others, are highly resistant to conventional therapies (chemotherapy, radio-therapy and surgery).Our Foundation provides support for stem cell research into these tumour types, aimed at dis-covering what it is that makes them so resistant and, as a result, at designing new therapies to solve this serious problem.

EXPERIMENTAL FOETAL SURGERY

In 2004, the Foundation began research into foetal surgery (operating on the foetus inside the mother’s womb) in animals (gestating sheep). After five years’ work, research was transferred to people with considerable success, as solu-tions were found for congenital diseases such as diaphragmatic hernia, myelomeningocele (spina bifida) and other conditions. We are now embarking on a new project that complements foetal surgery with stem cell research to help treat such diseases with regenerative medicine.

LUPUS ERYTHEMATOSUS RESEARCH The work of A. BOSCH FOUNDATION includes support for medical research into increasingly common and hard-to-cure rare diseases. Such is the case of lupus erythematosus: this au-toimmune (the body creates antibodies that attack healthy cells), multisystemic (it affects different organs) and chronic disease is a real challenge that has prompted us to seek new methods of treatment to solve it. For the time being, lupus erythematosus is still a rare disea-se of unknown cause and uncertain prognosis.

CONTRIBUTE

One of the objectives of the managers of the A. BOSCH FOUNDATION is to find funding for its different projects. “The aim is to obtain funds from companies, individuals and institutions to help the Foundation undertake its projects”.

The A. BOSCH FOUNDATION centralises the collection of different donations with a view to optimising and distributing the resources obtained to suit the requirements of each project.

Having these funds not only speeds up and enhances the chances of success in finding solutions to children’s cancer and other hard-to-cure diseases, but also helps to fulfil the wish of NOEL ALIMENTARIA S.A.U. to establish a fairer and more balanced society.

HELP US GROW!

WHAT TYPE OF CONTRIBUTION WOULD YOU LIKE TO MAKE?

Given that research lies at the core of the work of the A. BOSCH FOUNDATION, its outlook is inevitably long-term and projects thus require funding over time. The institution there-fore suggests three ways in which to contribute:

· OCCASIONAL DONATION

· PERIODIC DONATION

· DONATION TO SPONSOR A SPECIFIC PROJECT (the term sponsorship refers to support for one specific area of research).

All donations should be paid into the current account with IBAN ES57 0182 5439 5202 0150 2313 of the “A. BOSCH FOUNDATION”.

FUNDACIÓ PRIVADA A. BOSCHPla de Begudà · 17857 St. Joan les Fonts · GironaTel.: +34 972 293 142www.fundacioabosch.org

We Nourish Hope

We Nourish Hope

INVESTIGATIONand RESEARCHMedical Solutionsfor Childhood Diseases

We Nourish Hope

gelis

.cat

- O

lot 0

4/15

FUNDACIÓ PRIVADA A. BOSCHPla de Begudà · 17857 St. Joan les Fonts · GironaTel.: +34 972 293 142www.fundacioabosch.org

Anna Bosch Güell,president of the A. BOSCH FOUNDATION

We nourish the hope of improving people’s wellbeing throughout their lives.