Formulation of Kemangi Leaves Extract Lozenges (Ocimum sanctum L.) : The Effect of Carboxymethylcellulose Sodium As A Binder On The Tablet Physical Characteristic Created by : Catur Rahayu Graha Ayu Nina Rusmiyanti
Formulation of Kemangi Leaves Extract Lozenges (Ocimum sanctum
L.) : The Effect of Carboxymethylcellulose Sodium As A Binder On
The Tablet Physical CharacteristicCreated by:Catur RahayuGraha
AyuNina RusmiyantiBackground & PurposeP1Kemangi
leavesMaceration using ethanol 70% as solventThe lozenges were made
by wet granulation methodCMC-Na 0%CMC-Na 1,5%CMC-Na 3%CMC-Na
4,5%Granuled were produced by using machine of single punch table (
650 mg /tab )The granule & tablet were tested its physical
characteristic and analyzed theoretically & statistically by
analysis one way ( ANOVA) with the T testMethods of The
ResearchP2Result of The ResearchP3 3rd Formula ( CMC-Na 3%)5.40 kp
of Hardness0.098% of Friability7 minutes 30 seconds of Solubility
Time98.30% Extract Dissolute from The Tablets During 21
minutesResult of The ResearchP3Increase of binder
concentrationIncrease the hardness of lozengesReduce friability of
lozengesIncrease dissolve time of lozenges
