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Behcet's syndrome

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Behcet's syndrome

More common in Japan an d eastern Mediterrancountries where it has an association with HLA -

Characteristically targets enules.

ora1 ulcers are uniersal usually deep and mult

"or 1# - $# days.

%enital ulceration are less com mon & # ( )# *

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Skin lesions inform of erythema nodosum, acneifolesions, migratory thrombophlebitis and vasculitis

Pathergy reaction is hyper reactivity at the site minor trauma ( positive if a pustule develops withhrs. !.

"ccular involvement, anterior or posterior uveitisretinal vasculitis.

#eu rological involvement in $% cause hemiparesrecurrent thrombosis.

&enal involvement is rare.

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riteria for the diagnosis of Behcet 's syndrom

"ral ulceration ) minor aphthous , ma*or or heulceration at least + times in - month period.

Plus two of )

&ecurrent genital ulceration. /ye lesion.

Skin lesion.

Positive pathergy test.

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0reatment

0opical steroid for oral ulceration.

olchicine e1ective for erythema nodosum ,arthralgia and oral ulceration.

0halidomide for oral and genital ulceration.

"ral steroid in combination with otherimmunosuppressive

  drugs in systemic disease.

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