SRI KRISHNA PHARMACEUTICALS LIMITEDenvironmentclearance.nic.in/writereaddata/Online/TOR/25_Oct_2016... · Sri Krishna Pharmaceuticals Limited a largest producer of Paracetamol in

PRE-FEASIBILITY REPORT

FOR TERMS OF REFERENCES

October, 2016

SRI KRISHNA PHARMACEUTICALS LIMITED PLOT NO. B-14/1,

MIDC CHINCHOLI,

TALUKA- MOHOL,

SOLAPUR DISTRICT

MAHARASTRA

Studies & Documentation By M/S Pridhvi Enviro Tech pvt. Ltd

Submitted by (MoE&F O.M – S.NO: 122, rev 46,

dated 5.10.2016) Sri Krishna pharmaceuticals Ltd, 184/C, Lawn House Plot No. B-14/1 Vengal Rao Nagar

MIDC, Chincholi Hyderabad-500038

Taluka Mohol Ph: 040-40179770

Solapur (D) Fax: 040-66730926

Maharastra E-Mail: [email protected]

SUBMITTED TO MINISTRY OF ENVIRONMENT & FORESTS, GOI

PARYAVARAN BHAWAN, CGO COMPLEX,

LODHI ROAD, NEW DELHI-110003

CONTENTS

S.No. Description Page No.

1 Introduction 1

2 Introduction of the project 2

Introduction of the company and the

proponent

3

3 Project Description 4

3.1 Production Capacity 4

3.2 Manufacturing Process 5

3.3 Raw materials 5

3.4 Water Requirement 5

3.5 Waste generation and control systems 6

3.5.1 Liquid effluents 6

3.5.2 Solid waste management 9

4 Site Analysis 10

4.1 Plant location 10

5 Planning in Brief 16

6 Resource requirement 16

6.1 Power requirement and Supply/ Source 16

6.2 Production facilities , Utilities and

effluent handling facilities

16

6.3 Land requirement 17

7 Air pollution 18

8 Bulk chemical storage 18

9 Base line data studies 19

10 Project financial 19

LIST OF TABLES

LIST OF FIGURES

LIST OF ANNEXURES

Table No. Description Page No.

1.0 Salient Features of the Project 2

2.0 List of Proposed Products 4

3.0 Water Balance Proposed 5

4.0 Solid Waste and Disposal 9

5.0 Utilities /ETP-Proposed 16

6.0 Land Statement 17

7.0 Emission Source Proposed 18

8.0 Storage facilities of bulk chemicals 18

Fig No Description Page No.

1.1 Schematic treatment scheme of high

TDS effluents

7

1.2 Low TDS Effluent Treatment System 8

1.3 Topo Map of the Study Area 12

1.4 Base Map of the Study Area 13

1.5 Photographs of current condition of the

site

14

1.6 Site layout plan 15

Annexure Description

I Typical Technical details of proposed products

II List of Raw materials

Pre-Feasibility Report Sri krishna Pharmaceuticals Limited, B-14/1

1

1. Introduction

Sri Krishna Pharmaceuticals Ltd., engaged in manufacturing of Active

Pharmaceutical Ingredients, and Intermediates was established in the

year 1975. Research and Development forms the backbone of the

organization with state of the art instrumentation facilities. They have

Five manufacturing sites in India four in Telangana manufacturing bulk

drugs & formulations and one in Maharastra manufacturing Drug

intermediates.

Sri Krishna Pharmaceuticals limited proposed to establish a new unit at

Plot. No. B-14/1, MIDC, Chincholi, Taluka- Mohol, Solapur District,

Maharastra state.

The unit obtained TOR for the proposed unit from SEAC, Maharastra and

submitted Draft EIA Report based on Model TOR’s on June 28th 2014.The

proposed unit is located in Notified industrial Area, MIDC, Chincholi, As

the unit is within 5 KM from the proposed eco sensitive zone of the Nanaj

Sanctuary Great Indian Bustard sanctuary.

In the year 2014, Hon. Supreme Court had given directions to all State

Govts. to finalize the Eco Sensitive Zones(ESZ) for all the Protected Areas

coming under them. Further, directions were given by Hon. Supreme

Court that in absence of finalized ESZ or for a period till the ESZ gets

finalized, a distance of 10 Km from the boundary of PA would be treated

as ESZ.

Under such circumstances, as per the provisions in MoEF notification

dated 14.09.2006, any project in Cat. B coming in ESZ of a Protected

Area would be treated as Cat. A and hence the State Level EIA Authority

rejected the case and advised the company to approach MOEF in Delhi for

the clearance.


2

Hence this application is made for obtaining fresh TOR. As the unit is

located in IE, Chincholi which is notified industrial area established prior

to 2006 notification, Public hearing may be exempted for this unit.

2. Introduction of the Project

The proposed unit is to manufacture Bulk Drugs (APIs) to a tune of 1250

TPA. The salient features of the project are described in the table given

below

TABLE 1.0

Salient Features of the Project

Location B-14/1, MIDC, Chincholi (V), Mohol (Taluk), Solapur (D), Maharashtra.

Longitude and Latitude 17o44’39.8’’ N 75o 48’39.5’’ E

17o44’36.4’’ N 75o 48’47.4’’ E 17o44’32.4’’ N 75o 48’44.7’’ E

17o44’35.0’’ N 75o 48’37.7’’ E

Product Category 5(F) Bulk Drugs & Intermediates

Project Category as per EIA notification

Category A (located within 5 Km distance

from the proposed ESZ of GIB Nanaj

Sanctuary)

Proposed Activity Drugs & Drug intermediates- 1250 TPM

Total investment on the plant Rs. 95.0 Crores

Total Investment on Environmental

Infrastructure

Rs. 6.92 Crores

Total area of the plant 8.39 Acres

Total area of green belt 3.25 Acres

Water requirement Total water requirement for project will be 739 KLD. Fresh water will be 474 KLD and from water recycle 265 KLD

Source of water MIDC, Chincholi

Nearest habitation and distance

from the site

Kondi Village- 1.95 Km from the site (E)

Nearest surface water bodies Sina river is at a distance of 1.91 km

from the site

Nearest reserve forest There are no reserve forests in 10 km radius from the site

Environmentally sensitive areas within 10 km radius

None

Any national parks, wild life

sanctuaries within 10 km radius

GIB Nanaj Sanctuary is at a distance of

9.88 Kms from the site.


3

Proposed Eco Sensitive Zone of GIB

Nanaj Sanctuary- 0.6 Kms

Nearest air port and distance Solapur Airport-18.55 km

Nearest railway station and distance

Pakni Railway Station-3.95 km

National Highway NH-9 is at a distance of 0.52 Km from the site

i) Introduction of the company and proponent

The company has Headquarter in Hyderabad, India, and is catering to the

ever growing demand of Active Pharmaceutical Ingredients (API’s) from

single State-of-the-art manufacturing facility. Already established unit in

Chincholi MIDC (Maharashtra) and has built up a reputation for excellence

on the foundations of consistent high quality, a constantly expanding

product portfolio and timely launches of new API’s.

The in-house QC Laboratories are equipped with sophisticated

instruments to assure the quality of the raw materials, intermediates and

API’s. The company believes in quality by design and continuous

improvement in all aspects of its operations. By this endeavor, Sri Krishna

Pharma necessitates to recognize in the global market of Pharmaceuticals

as an important partner for API’s.

About Proponent

The management at Sri Krishna Pharmaceuticals Limited, consists of

highly qualified and richly experienced persons who have given the

company the edge in terms of quality, consistency, timely delivery and

ability.

The Group is headed by a technocrat with academic excellence. Dr. V.V.

Subba Reddy, Founder Chairman is a Post Graduate in Technology,

Doctorate in Science and a Post-Doctoral fellow from National Cancer

Institute, NIH, Maryland, USA. He also serves various trade associations,

Government bodies and Institutions as a representative of the

pharmaceutical industry in India.


4

About the Unit

Sri Krishna Pharmaceuticals Limited a largest producer of Paracetamol in

India with a capacity of 6000 MT/year and largest producer of Folic Acid in

the world with a capacity of 250 MT/year.

Quality Management: Strict quality control measures, Good

Manufacturing Practices (GMP) are integrated throughout the

manufacturing process to ensure strict adherence to the quality

parameters for both in-process and finished products.

3. Project Description

3.1 Production Capacity

Sri Krishna Pharmaceuticals Limited, B-14/1 intends to manufacture 1250

TPM of API products (Bulk Drug & Intermediates) products. Product wise

capacity is given below:

TABLE 2.0

PROPOSED PRODUCTS & CAPACITY

S.No Name of the

Products Quantity in

TPM Remarks

1A Paracetamol- 4 stages

50

Starting from PNCB - 4 Stages,

1B Paracetamol- 2 stages

950 Starting from penultimate stage -2

Stages

2 Ibuprofen 200

3 Domperidone 10

4 Docosa Hexaenoic

Acid (DHA) 20

5 Lovastatin 20

Total 1250

By Product

1 Acetic Acid

1192.0

Generated in the process and sold to consumers

2 Soap 80.0


5

3.2 Manufacturing Process

Typical Brief process description and process flow charts are given at

Annexure I

3.3 Raw Materials

List of raw material product wise is given at Annexure II

3.4 Water Requirement

The water requirement for process, domestic, gardening, boiler feed & for

cooling water make up is about 739 KLD. The source of water is already

available from existing water works of MIDC and the same is adequate

and satisfactory. The water balance for daily consumption is presented

below.

TABLE 3.0

Water Balance–Proposed

S.

No

Stream Water

requirement in KLD

Waste

Water discharge

in KLD

Proposed Method

of Treatment and Disposal

1 Process 290.0 352.0 Stripper, MEE and

ATFD (Condensate to RO)

2 Washings

5.0 5.0

3 Laboratory

washings

1.0 1.0

4 Scrubbers 25.0 25.0

5 Boiler 100.00*

10.0 ETP followed by RO ( RO Reject to MEE)

4 DM/Softener 3.0 3.0

5 Cooling &

Regeneration

255.00 26.0

6 Domestic 50.00 40.00 Sewage Treatment

Plant & reused for gardening &

flushing’s

7 Gardening 10.00 -

Total 739.0 462.0 *includes 85 KL condensate recycle


6

3.5 Wastes generation and control systems

3.5.1 Liquid Effluents

As detailed in Table 3.0 waste water generation would be 462.0 KLD. It is

proposed to segregate effluents into high COD and High TDS stream and

Low COD and Low TDS streams.

High TDS and High COD stream would be treated in stripper followed by

MEE and ATFD. The resultant sludge would be disposed to TSDF,

Hyderabad. The Low TDS stream would be treated along with MEE/ATFD

condensates in biological ETP followed by RO. The RO rejects would be fed

back to MEE. The Permeate from RO would be used for cooling tower

make up. Domestic effluents are treated in sewage treatment plant. Thus

the treatment system proposed is based on “Zero Liquid Discharge” (ZLD)

Concept

The schematic diagrams of ETP proposed are given in Figure 1.1 and

Figure 1.2 below

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9

3.5.2 Solid wastes management

Hazardous and non - hazardous wastes generated from the proposed

project are detailed below. Mode of disposal are also identified and listed.

Adequate storage of hazardous waste is ensured at the site

TABLE 4.0

Solid Wastes and Disposal

S.No

Type of waste Schedule No.

Quantity in TPM

Disposal

Hazardous waste

1 ETP Sludge 34.3 30.0 CHWTSDF

2 MEE salts and inorganic residue

34.3 870.6

CHWTSDF

3 Spent carbon 28.2 308.4 CHWTSDF

4 Distillation bottom Residue/process sludge

20.3 775.6 Authorized cement Industries/ CHWTSDF

5 Spent solvents 28.5 40.0 CHWTSDF

6 Iron sludge 28.1 72.5 Authorized cement Industries

7 oil from process 5.1 20.0 Authorized recyclers/

CHWTSDF

8 Waste oil 5.1 0.2 Authorized recyclers/

CHWTSDF

9 E- Waste 31.1 As and when generated

Send to E- waste Recycler

10 Used Lead acid batteries

- As and when generated

Return to supplier for replacement in exchange

Biodegradable waste

1 ETP Bio sludge - 10.0

Composting and used as manure for

gardening


10

Non Biodegradable waste

1 Waste paper - 100.0

Kgs/month Sale

2 Corrugated boxes - 500.0

Kgs/month Sale

3 Broken glass - 100.0

Kgs/month Sale

4 Decontaminated

used drums -

500.0

Kgs/month Sale

5 Decontaminated HDPE Bags

- 500.0

Kgs/month Sale

6 Coal ash - 280.0 Sale

CHWTSDF facility at Ranjangaon which is at a distance of 200 Km from

the site has agreed to cater the solid waste from the proposed site.

Transport of Hazardous wastes to TSDF is done by the CHWTSDF. In case

other hazardous wastes, authorized recyclers will transport the wastes.

4. Site Analysis

4.1 Plant Location

M/S Sri Krishna Pharmaceuticals Limited, B-14/1, MIDC, Chincholi(V),

Mohol (T), Solapur(D), Maharastra state. The site is situated at the

following Latitudes and longitudes

17o44’39.8’’ N 75o 48’39.5’’ E

17o44’36.4’’ N 75o 48’47.4’’ E 17o44’32.4’’ N 75o 48’44.7’’ E 17o44’35.0’’ N 75o 48’37.7’’ E

The land area of the plant is 8.39 acres. The nearest habitation from the

site is Kondi (V) at a distance of 1.95 km. The nearest railway station

located at Pakni 3.95 KM from the Plant. Great Indian Bustard (GIB)

Nanaj Sanctuary which is ecologically sensitive area is at a distance of

9.88 Km from the site and the proposed Eco sensitive zone of the GIB


11

sanctuary is at a distance of 0.6 Km from the site. There are no reserve

forests in 10 Km radius.

Following are the surroundings of the site

North – Road followed by LHP Limited

East- Betul Oil company

South- Sri Krishna Pharmaceuticals unit -V

Topo graphic features of the site and 10 KM study area and base map are

given at Fig 1.3 & 1.4.

Plant & Green Belt Photographs are given at Fig. 1.5

Site lay out map is given at Fig 1.6

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16

5.0 Planning in Brief

The project is envisaged to be completed by November 2017, and the

production shall be initiated thereon. Consultants are identified for

preparing the detailed project report.

6. Resource requirements 6.1 Power Requirement and Supply/Source

The total power requirement for the proposed project is 4000 HP. It shall

be sourced from MSEDCL and D.G sets are proposed as alternative to

Power failure.

6.2 Production facilities, Utilities and effluent handling facilities

It is proposed to add additional production facilities, utilities and effluents

treatment infrastructure with an investment of Rs.95.0 Crores. The details

are outlined in the below table

TABLE 5.0

S.NO Details

Capacity/

No Proposed

Production facilities

1 Production Blocks Nos 6

2 Bio Tech Blocks Nos 2

3 Clean rooms Nos 1

4 Boiler (coal Fired) TPH 1 x20 & 1x10*

5 DG sets KVA 2 X 1000

6 Cooling tower TR 2500

7 Softner/DM plant M3/hour 2.5

8 Fresh water RO Plant M3/hour 2.0

Effluent handling & treatment facilities

9 Collection tanks-Storage

KL 500

10 Neutralisation tanks KL 10

11 Stripper, MEE, ATFD KLD 2 X 200

12 RO & Biological treatment

KLD 400

13 Sewage treatment plant KL 40

* 1 X 10 TPH Boiler is Stand by boiler


17

6.3 Land Requirement

The unit currently has 8.39 acres of land and out of which 3.25 acres of

green belt will be developed. The land requirement for proposed activities

will be 10052 Square meters (2.5 Acres) which can be met from existing

open area. Below table provides the land statement. Detailed site lay out

plan outlining proposed activities is given at Figure 1.6

Table 6.0 Land Statement

S. No Block Area in Sq. meters

1 Raw Material Stores-1 813.75

2 Raw Material Stores -2 813.75

3 Utility Block 273.0

4 Boiler House 273.0

5 Coal & Ash yard 126.0

6 Engineering work shop 126.0

7 ETP 199.5

8 Hazardous waste storage area 199.5

9 MEE 399.0

10 Production Block-I Para 494.0

11 Production Block-II Para 503.75

12 Production Block-I Dom 494.0

13 Production Block- II Dom 503.75

14 Production Block-I Ibu 503.75

15 Production Block-II Ibu 494.0

16 Biotech Block-I 503.75

17 Bio Tech Block- II 503.75

18 Above ground acid storage tank 494.0

19 Finished goods storage 494.0

20 Admn Office, QA, QC 503.75

21 U/G Storage tanks 1026.0

22 Transformer yard 120.0

23 Electrical room 40.0

24 Generator room 40.0

25 Water sump, Pump house 90.0

26 Security 20.0

Total 10052.0


18

7.0 Air Pollution

The Sources of air emissions from the plant are from 20 TPH coal fired

Boiler and stand by 10.0 TPH coal fired boiler and DG sets

The process emissions Contain Acetic acid fumes, CO2, H2 & HCl. Acetic

acid fumes and HCl are scrubbed with caustic and scrubbed waste send to

MEE. Below Table gives proposed emission sources from the plant

Table 7.0 Emission Source –Proposed

S.No

Parameter Capacity Fuel Anticipated emissions

Control system

1 Process --- -- HCl, Acetic acid fumes

Scrubber

2 Boiler Stack 20 TPH; 10

TPH stand by

Coal SPM, SO2,

NOx

Common stack

with height of 50 meters,

cyclone and dust collector

3 DG sets 2x1000 KVA Diesel SPM,SO2

&NOx

Stack Height 6.5 Mts,

Acoustic enclosures

8.0 Bulk Chemical Storages:

Following bulk chemical storage facilities are proposed

Table No 8.0

Storage facilities of bulk chemicals

S.No Name of the

raw material.

MOC Mode of

storage

No Of

Tanks

Storage

Quantity

1 Isopropyl alcohol

MS Below Ground

1 20KL

2 Isobutyl

Benzene

MS Below

Ground

1 20KL

3 Isobutyl

Acetophenone

MS Below

Ground

1 20KL

4 Isopropyl Chloro

MS Below Ground

1 20KL


19

acetate

5 Acetone MS Below Ground

1 20KL

6 O-Xylene MS Below

Ground

1 20KL

7 Toluene MS Below

Ground

2 40KL

8 Methanol MS Below Ground

1 20KL

9 MIBK MS Below Ground

1 20KL

10 Caustic Lye (48%)

MS Above Ground

1 25KL

11 Sulphuric Acid MS Above

Ground

2 50KL

12 Acetic

anhydride

Aluminu

m

Above

Ground

1 25KL

13 HCl PP-FRP Above Ground

2 50KL

14 Liquor ammonia

25%

MS Above Ground

1 25KL

15 Acetic acid SS Above Ground

2 50KL

16 Ammonia-LIQ cylinders Above Ground

1 25KL

9. Baseline data studies

We have a unit at B-14/2 in MIDC Chincholi which is in the same MIDC

of the proposed site for which baseline data has been collected during the

period of April 2016 to June 2016 so we request you to kindly allow us to

consider the same data for current study.


20

10. Project Financial

The estimated cost of the proposed project is approximately 95.0 Crores.

Out of this Rs. 6.92 Crores will be for effluents treatment facilities and

rest for other process equipment and safety equipment

Project cost

Rs. In

Crores

Plant& machinery 50.0

Civil & Structural 15.0

Total 65.0

Pipe lines & insulation

20% on plant &

machinery 10.0

Electricals & instrumentation 10% on plant & machinery 5.0

Erection & commissioning & painting

8% on plant &

machinery and structures 4.0

Safety & Environment 10.0

Furniture, fixtures, computers, lighting etc 0.5

Total 94.5

Contingencies & pre-operative

expenses 0.5

Project cost say 95.0 Crores

Annexure I

Typical technical details of the proposed products

PARACETAMOL

Process description and flow sheets

Brief manufacturing process of Paracetamol

Stage-1 (Hydrolysis)

Para Nitro Chloro Benzene is treated with aqueous sodium hydoexide at a temperature of 135-

140oC in an autoclave and neutralized with sulphuric acid to get Para Nito Phenol.

Stage- 2 (Reduction)

Para Nitro Phenol is reduced in boiling water under mild acidic condition with iron poweder

and acetic acid to get Para Amino Phenol,

Stage -3 (Acetylation)

Para Amino Phenol is condensed with Acetic Anhydride in aqueous medium to get

paracetamol and acetic acid.

Stage-4 (Purification)

Paracetamol technical is dissolved in hot water, treated with carbon, crystallized to get

Paracetamol with is dred, milled and packed in LDPE lined HDPE bags.

CHEMICAL PATHWAY OF PARACETAMOL SYSNTHESIS

Stage I -P-Nitro Phenol:

Cl

+ 2NaOH + NaCl + H2O

ONa

NO2

161

NO2

PNCB

157.5

Step 2.

ONa

NO2

161

+ 0.5 H2SO4

OH

NO2

+ 0.5 Na2SO4

0.5 x 142

139

Step 1.

2 x 40 58.5 18

Para Nitro Phenol

(PNP)

OH

NO2

+ 18 Fe + 7H2O+ 9FeO + 3Fe3O4+ xCH3COONa + xH2O

82

7 x 139

18x55.84 7x18xCH3COOH + xNaOH

OH

NH2

7 x 109

60 40 6Fe3O3.5(Av)

6 x 223.52

7

Stage -II - P-Amino phenol:

PNP Para Amino Phenol

(PAP)

18

O

O

S T A G E I II - P a ra c e ta m o l T e c h n ic a l

O H

N H 2

+C H 3 C

O

CC H 3

O H

N H C O C H 3

+ C H 3C O O H

6 0

1 5 11 0 21 0 9

P A P A c e tic A n h yd r id e P a ra c e ta m o l

S ta g e - IV - P a ra c e ta m o l P h a rm a

O H

N H C O C H 3

O H

N H C O C H 3

+ S pen t ca rbonA ctiv e C a rbon

Ph a rm a M L

PARACETAMOL

PROCESS FLOW DIAGRAM

4-Nitrochlorobenzene

Caustic soda Lye

Water

Stage I

Sulphuric acid

Aq layer

PNP

PAP ML / Water

Dilute Acetic acid

Iron powder

Caustic soda Lye

Stage II

Iron sludge

Hydros

SMBS Aq layer

PAP PAP ML

Pharma ML

Acetic anhydride

Soda ash

EDTA

Hydros

SMBS

Stage III

Hydrolysis

Conversion of PNCB to Nitrophenol

(PNP)

Neutralisation

Reduction

Conversion of PNP to

Aminophenol (PAP)

Filtration

candle filter

Cooling and Filtration

Pusher Centrifuge

Acetylation

Conversion of 4-Aminophenol

(PAP) to Paracetamol technical

Filtration

Pusher Centrifuge

Process water/Pharma ML

Soda ash

Activated carbon

Hydros

SMBS

Stage IV

Hydros Pharma ML

DM Water

Acetaminophen (Paracetamol) pharma (wet)

Carbon treatment

Filtration through Leaf

filter and Polishing filter

Recrystallisation

(cooling)

Filtration through

Agitated Nutsche Filter

Acetaminophen Technical

Annexure II

List of Raw Materials

List of Raw Materials of Paracetamol (Starting

from PNCB)

S.No Name of raw material

Qty

(Kgs/day)

1 PNCB 2008.7

2 Caustic Lye (48%) 8486.6

3 Sulphuric Acid 750.2

4 Iron Powder 1810.4

5 Acetic Acid (20%) 841.8

6 Acetic anhydride 1273.6

7 EDTA 1.7

8 Hydros 3.3

9 SMBS 1.7

10 Activated Corbon 15.0

11 Sodium Hydro Sulphite(Hydros)

1.7

12 Sodium Meta Bisulphite(SMBS) 1.7

13 Caustic flakes 11.7

List of Raw Materials of Paracetamol

(Starting from PAP)


Qty

(Kgs/day)

1 PAP (1% ) moisture) 25237.8

2 Acetic anhydride 24192.8

3 EDTA 31.7

4 Hydros 63.3

5 SMBS 31.7

6 Activated Corbon 285.0

7

Sodium Hydro

Sulphite(Hydros) 31.7

8

Sodium Meta

Bisulphite(SMBS) 31.7

9 Caustic flakes 221.7

List of Raw Materials of Ibuprofen


Qty

(Kgs/day)

1 Mono Chloro acetic acid 4572.9

2 Iso propyl alcohol 3352.8

3 Sulphuric acid 1668.0

4 Sodium bi carbonate 328.9

5 Sodium carbonate 82.2

6 Isobutyl benzene 5154.0

7 Acetyl chloride 3412.2

8 Aluminum chloride 5856.8

9 Conc. Hcl 30% 509.3

10 Liq Ammonia 25 % 509.3

11 Sodium metal 1265.6

12 Isopropyl alcohol 16718.0

13 CS Lye 48% 5872.6

14 Sodium dichromate dehydrate 3518.7

15 Sulphuric acid 6481.8

16 Acetone 16297.1

17 N- Hexane 9074.5

List of Raw Materials of Domperidone S.No Name of raw material Qty (Kgs/day)

1 Orthophenylene di amine(OPDA) 186.0

2 Methyl Aceto acetate(MAA) 199.7

3 Xylene 797.3

4 Caustic lye 48 % 165.0

5 Carbon 12.3

6 Conc. HCl 30 % 245.7

7 1- bromo-3-chloro-propane 223.3

8 Toluene 796.7

9 Potassium carbonate 210.0

10 Conc. HCl 30 % 213.3


12 N- Methyl Piperidone 240.0

13 Ethyl chloro formate 320.0

14 CS Flakes 193.3

15 Toluene 863.3

16 Methanol 336.7

17 Raney Nickel 6.7

18 Ammonia gas 50.0

19 Hydrogen 3.3

20 DCNB 343.3

21 K2 CO3 200.0

22 Toluene 573.3

23 Potassium carbonate 100.0

24 Potssium chloride 106.7

25 Toluene 956.7

26 Methanol 573.3

27 Raney Nickel 23.3

28 Hydrogen 10.0

29 Urea 170.0


31 Ammonium chloride 383.3

32 Carbon 3.3

33 Conc. HCl 30 % 140.0

34 Ammonia 30% 286.7

35 Soda ash 123.3

36 MIBK 1190.0

37 Methanol 3176.6

38 Carbon 13.3

39 Acetic acid 116.7

40 Ammonia 33.3

List of Raw Materials of Omega-3


Qty

(Kgs/day)

1 Sea water 32016.0

2 Dextrose 17342.0

3 Toluene 6670.0

4 Crude oil 2668.0

5 Alkali Solution 1334.0

List of Raw Materials of Lovastatin


Qty

(Kgs/day)

1 Mixed material 5467.4

2 Dextrose 19400.4

3 Seed 1657.8

4 Toluene 49911.9

5 Iso propyl alcohol 1410.9

6 Activated carbon 9347.5

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SRI KRISHNA PHARMACEUTICALS LIMITEDenvironmentclearance.nic.in/writereaddata/Online/TOR/25_Oct_2016... · Sri Krishna Pharmaceuticals Limited a largest producer of Paracetamol in