The skin cohesiondesigner

SqisandrylTM

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Overview

Efficacy

Plant origin–

Ecocertcertified

Regulatory

Extraction process

Scientificstory

Sqisandryl™ concept&

Efficacy

Our value proposition

Technicaldata

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Sqisandryl™ concept&

Efficacy

Our value proposition

Technicaldata

Overview

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Sqisandryl™ concept

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With Sqisandryl™

Dermal-Epidermal

Junction

FOCUS on

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With Sqisandryl™

Collagen XVIILadinin-1

Stimulation of collagen XVII and ladinin-1 synthesis

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Collagen XVII and Ladinin-1

Ladinin-1

Play a major role in cohesion & tensionbetween dermis & epidermis,Involved in deseases when severely lacking.

Collagen XVIISynthesized by

EpidermalKeratinocytes

2 “tension molecules”

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Definition: structural component of the dermo-epidermal anchoring complex

Location: DEJ (Lumina lucida)

Main function: cell-matrix adhesion molecule throughstabilization of the hemidesmosome complex.

Collagen XVII: collagenous transmembrane protein

Powell AM, et al., 2005, Collagen XVII/BP180: a collagenous transmembrane protein and component of the dermo-epidermal anchoring complex, Exp. Dermatol., 30:682-687

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Definition: anchoring filament that is a component of basement membranes

Location: synthesized and secreted by epidermal keratinocytes DEJ (Lumina lucida)

Main function: may contribute to the stability of the association of the epithelial layers with the underlying connective tissue

Ladinin-1: component of basement membranes

El Ghalbzouri A, et al.: Basement membrane reconstruction in human skin equivalents is regulated by fibroblasts and/or exogen activated keratinocytes, JID., 124:79-86, 2005

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As we aged…

Keratinocytes metabolism slows down

1

Coll. XVII and Ladinin-1

proportions are expected to decrease

2

SKIN SLACKENING,

LOSS OF FIRMNESS

No more dermal-epidermal tension,

DEJ deformation

3

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With Sqisandryl™…

Stimulates Collagen XVII and Ladinin-1 synthesis

Dermal-epidermal dynamic cohesion is

recoveredNEW

Consumer Benefits

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NEW CLAIMS related to DEJ on the market

Beyond wrinkles or firmness correction and moisturization…

…Sqisandryl™ improves

simultaneous

ELASTICITYRESILIENCE

FIRMNESS

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Sqisandryl™

Efficacy

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Sqisandryl™

In vitro results

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Collagen XVII stimulation

In vitro

On keratinocytes culture

Expression of the COL17A1 gene detected and quantified by qRT-PCR

The collagen XVII protein is detected by immunocytochemistry

+67%

6×

SqisandrylTM increases

Collagen XVII synthesis up to 6 times

Col17A1 mRNA expression by 67%

Mean of 4 assays – U test of Mann and Whitney – *: p<0.05 Mean of 3 assays – U test of Mann and Whitney – **: p<0.01

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Control SQISANDRYL™ at 0.006% SQISANDRYL™ at 0.01%

In vitro

On keratinocytes culture The collagen XVII protein is quantified by image analysis

Collagen XVII stimulation

Image analysis

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In vitro

On keratinocytes culture Expression of the LAD-1 gene detectedand quantified by qRT-PCRThe ladinin-1 protein is detected by immunocytochemistry.

LAD-1 mRNA expression by 68%

+68%

Ladinin-1 stimulation

Sqisandryl™ increases

3.5×

Ladinin-1 synthesis up to 3.5 times

Mean of 5 assays – U test of Mann and Whitney – **: p<0.01 Mean of 3 assays – U test of Mann and Whitney – **: p<0.01

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In vitro

On keratinocytes culture The ladinin-1 protein is quantified by image analysis

Control SQISANDRYL™ at 0.006% SQISANDRYL™ at 0.01%

Ladinin-1 stimulation

Image analysis

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Sqisandryl™

The clinical study

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1 group of 17 subjects women over 60 with a slackening of elasticity and firmness on the face. 8 weeks of treatment, half face application twice a day.

Evaluation of Skin biomechanical properties measurements over time with Cutometer® at D0, D56.

Protocol

Sqisandryl™ at 0.3%*

Placebo*

* Hydrogel formulation

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Skin elasticity

After 56 days,skin elasticity is

improved by 28%

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Skin resilience

After 56 days,resilience is

improved by 8%

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Skin firmness

After 56 days, skin firmness is improved

by 25%

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Overview

Efficacy

Plant origin–

Ecocertcertified

Regulatory

Extraction process

Scientificstory

Sqisandryl™ concept&

Efficacy

Our value proposition

Technicaldata

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Our value proposition

Efficacy

Plant origin–

Ecocertcertified

Regulatory

Extraction process

Scientificstory

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26

Our value proposition

Northern China RussiaKorea

Geographic

origin

“five-flavor berries”běi wǔ wèi zi (Mandarin)Omicha (Korean)Magnolia vine

Com

mon nam

esPlant

origin

–

Ecocert

certified

Schisandra chinensisberry

For 2000 years, one of the 50 important Chinese herbal

medecineHis

tory

Help to beautify the skinMaintain the body’s tonicity

Improve concentration and attentionIncrease physical and mental performance

Prevent and treate heart diseases

Trad

ition

al u

ses

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Our value proposition

Extraction process

Supercritical CO2extraction advantages:

- safe and clean,

- allows the complete elimination of solvent,

- remarkable solvent properties, non-destructive,

- confers a unique phytochemical profile on Sqisandryl™

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Our value proposition

RegulatoryAll the raw materials comprising the INCI name SqisandrylTM are listed on the "International Cosmetic Ingredient Standard Chinese Name"(2007 version)

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Our value proposition

Scientificstory

Efficacy

Identification of 2 “tension molecules” of the DEJ:

- collagenXVII,- ladinin-1.

Create a NEW s c i e n t i f i c s t o r y about the DEJ.No cosmetic active ingredient on the market with these targets.

Sqisandryl™ reinforces the dynamic cohesionbetween the dermis and the epidermis.

The skin is more elastic, more resilient and firmerin appearance in only 8 weeks.

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Overview

Sqisandryl™ concept&

Efficacy

Our value proposition

Technicaldata

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Process: Supercritical CO2 extraction (innovating and eco friendly process)

Aspect: yellow to orange oily liquid, with characteristic odor

Dose of use: 0.1 – 0.5% (recommended 0.3%, skin care applications)

Solubility: soluble in oils and fats

Preservatives: none

Ecocert: Raw material certified by Ecocert Greenlife according to the Ecocert Standard for Natural and Organic Cosmetics available at http://cosmetics.ecocert.com: 100% of the total ingredients are from natural origin, 100% of the total ingredients are from Organic Farming.

SqisandrylTM LS 9905Technical data

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INCI Name (EU/US): Schizandra Chinensis Fruit Extract

CAS number: 223748-53-6

Patent application WO 2005/044289 A2: EP (DE, FR, ES, IT, GB), US, JP

Japanese regulation: Cannot be used for cosmetic product in Japan

Chinese regulation:

SqisandrylTM LS 9905Regulatory data

MOH 2003 (1) INCI 2007 (2) INCI 2010 (3)

(1) INCI name/plant name whether or not listed in 'MOH Approved Used Cosmetic Ingredients (2003)(2) INCI name whether or not listed in "International Cosmetic ingredient standard Chinese name"(2007 version)(3) INCI name whether or not listed in "International Cosmetic ingredient standard Chinese name"(2010)

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SqisandrylTM LS 9905Toxicological/Safety data

EPISKIN: skin irritation in vitro

BCOP: eye irritation in vitro

IMDS: the modified Local Lymph Node Assay (sensibilization on animal)

AMES: Salmonella typhimurium Reverse Mutation Assay (in vitro mutagenicity )

Phototoxicity: in vitro

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Oil solubleSuitable pH: 4-8

Hydrogel formulation with 0.3%

Sqisandryl™

O/W cream formulation with 0.3% Sqisandryl™

SqisandrylTM LS 9905Formulation

Easy to formulate in all types of formulation

Low impact (color/odor)

in formulation at 0.3%

The active ingredient Sqisandryl™

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From traditional use… 3 NEW consumer benefits:ELASTICITYRESILIENCEFIRMNESS

…to NEW cosmetic application.

Sqisandryl™The Skin Cohesion Designer

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Sqisandryl™The Skin Cohesion Designer

Reinforcement of the dynamic cohesions between the dermis

and the epidermis.

Stimulation of collagen XVII and ladinin-1 synthesis,

two “tension molecules” of the DEJ

Remodeling face care

Skin restructuring treatments

Skin repair elixir

Make-up (foundation, lipstick)

PRO

PERT

IES

APP

LICA

TIO

NS

Men and women + 45 yo

TARG

ETED

CO

NSU

MER

S

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Disclaimer

“Although all statements and information in this publication are believed to be accurateand reliable, they are presented gratis and for guidance only, and risks and liability forresults obtained by use of the products or application of the suggestions described areassumed by the user. SELLER MAKES NO WARRANTY OF ANY KIND, EITHEREXPRESS OR IMPLIED, BY FACT OR LAW, INCLUDING WARRANTIES OFMERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Statements orsuggestions concerning possible use of the products are made without representationor warranty that any such use is free of patent infringement and are notrecommendations to infringe any patent. The user should not assume that toxicity dataand safety measures are indicated or that other measures may not be required. Theclaims and supporting data provided in this publication have not been evaluated forcompliance with any jurisdiction’s regulatory requirements and the results reportedmay not be generally true under other conditions or in other matrices. Users mustevaluate what claims and information are appropriate and comply with a jurisdiction’sregulatory requirements. Recipient of this publication agrees to (i) indemnify and holdharmless each entity of the BASF organization for any and all regulatory action arisingfrom recipient’s use of any claims or information in this publication, including, but notlimited to, use in advertising and finished product label claims, and (ii) not present thispublication as evidence of finished product claim substantiation to any regulatoryauthority.”