Spring 2016 Principles of Neurophysiology (BIONB/BME/ECE 4910) Lecture: 106 Comstock Hall; Lab: B150 Comstock Hall

Web Site: http://courses.cit.cornell.edu/bionb4910/index.html *Blackboard *

Instructors: Dr. Bruce Johnson, Yi-Yun Ho, Joannalyn Delacruz

Teaching Assistant: Irwin Tendler

1. Gain an intuitive understanding for important concepts in Cellular Neurobiology. 2. Gain experience and competence in electrophysiological techniques (Job Skills!) 3. Understand and appreciate the experimental paradigms of the field. 4. Polish your scientific thinking and writing. 5. Appreciate the personal excitement of a research physiologist interacting with a living system. What’s a Model System? What are the main research model systems?

4910 Course Objectives

Fab 4 Research Model Systems (not to scale!)

Why are invertebrate animals used as model systems to teachsignal transmission in human nervous systems?

Reasons to use invertebrates for teaching neuroscience

1. Evolutionary conservation of excitability and synaptic transmission2. Inexpensive to buy and maintain3. No animal protocols (no IAUCUC)4. Hardy nervous systems5. Often cultured for food

500 million

Neuronal excitability and synaptic trans-mission changed little in a half-billion years

Hille, 2001

"Never the less, all living things are about the same" C. Darwin

Spring 2016 Schedule

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Time (ms)

Ampl

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(mV)

Telson stimulated

4910 Schedule (cont)

Required “Texts”

Wyttenbach, R.A., Johnson, B.R. and R.R. Hoy (2014) Crawdad: An Online LabManual for Neurophysiology. Sinauer Associates, Inc. Sunderland, MA.

http://www.sinauer.com/crawdad-an-online-lab-manual-for-neurophysiology.html

Moore, J.W. and A.E. Stuart (2007) Neurons in Action, Vers. 2, Sinauer Associates, Inc., Sunderland, MA (http://www.sinauer.com/catalog/neuroscience/neurons-

in-action-2-tutorials-and-simulations-using-neuron.html )“Order from the website for a 15% discount from the suggested list price as reflectedin “price to individuals” and free standard shipping to US addresses on orders over $40.00.*

A.   35%- Lab Reports

B.   15%- Problem Sets and Other Assignments

C.   20%- Midterm Paper

D.   30%- Final Paper (25%) and Presentation (5%)

Submit to BLACKBOARD!

4910 Grading

Lab exercise

Results Due

ReportDue

A.  35%- Lab Reports

B.   15%- Problem Sets and Other Assignments

C.  20%- Midterm Paper

D.   30%- Final Paper (25%) and Presentation (5%)

4910 Grading

Blackboard; Neuronal Simulation Assignments

Tutorial Assignment Page Due DateAssignment 1: Introduction to NIA 1 January 30

The Membrane Tutorial 9

A.  35%- Lab Reports B.  15%- Problem Sets and Other Assignments C.  20%- Midterm Paper D. 30%- Final Paper (25%) and Presentation (5%)

4910 Grading

A.  35%- Lab Reports B.  15%- Problem Sets and Other Assignments C.  20%- Midterm Paper D.  30%- Final Paper (25%) and Presentation (5%)

4910 Grading

Extra  credit  for  helping  lead  lab  exercises  for  an  Engineering  class!

10 s

20 mVSnail neuron

Next weekFirst Lab: Model Neuronmembrane resistance, time constant, oscilloscope.LabChart software tutorial