ISBN: 978-1-5108-6302-6

Society for Biomaterials Annual Meeting and Exposition 2018

Atlanta, Georgia, USA 11 - 14 April 2018

Part 1 of 2

Transactions of the 41st Annual Meeting Volume XXXIX

Exploring the Nexus of Research and Application

Copyright and Disclaimer

41stX

1120 Route 73 Suite 200

18

8

TABLE OF CONTENTS

PART 1

CONCURRENT SESSION 1 FABRICATION AND 3D PRINTING OF TISSUE ENGINEERING Nanoengineered Ionic-Covalent Entanglement Reinforced Bioinks for 3D Bioprinting ........................................................................... 1

D Chimene, C Peak, J Gentry, J Carrow, L Cross, E Mondragon, G Cardoso, R Kaunas, A Gaharwar

Stem Cell-laden Alginate Microgel Bioink for 3D Bio-printing .................................................................................................................... 2O. Jeon, T. Hinton, A. Fein-berg, E. Alsberg

3D-Painting Porosity: A New Approach to Creating Elevated Porosity Biomaterials via Rapid 3D-Printing........................................ 3A. Jakus, N. Geisendorfer, P. Lewis, R. Shah

Purified Collagen Bioink for 3D Bioprinting .................................................................................................................................................. 4B Bagley

Reverse Engineered Three Dimensional Nerve Construct ............................................................................................................................ 5R. Dhandapani, J. Radhakrishnan, S. Sethuraman, A. Subramanian

3D Bioprinting of Tissue Engineered Vascular Graft with Nanoengineered Colloidal Inks ..................................................................... 6K. Gold, R. Dedas, A. Jain, A. Gaharwar

Rapid Stereoli-thography Printing of Human-scale Vascularized Tissue ................................................................................................... 7N Anandakrishnan, H Ye, C Zhou, R Zhao

3D Printing a Collagen Heart Valve Using Freeform Reversible Embedding of Suspended Hydrogels.................................................. 8A Hudson, T Hinton, A Feinberg, A Lee

BIOMATERIALS FOR CARDIOVASCULAR REGENERATION Regulation of Endothelial Function and Fate by the Extracellular Matrix ............................................................................................ N/A

Ngan Huang

Predicting Cardiac Reprogramming Outcomes on Biomaterials via Systems Biology .............................................................................. 9Y. Kong, A. Rioja, X. Xue, Y. Sun, J. Fu, A. Putnam

Novel Peptide Combinations Support Dynamic Adhesion of Endothelial Colony Forming Cells .......................................................... 10Y Tian, W Seeto, E Lipke

Stretchable ECM Membrane Enhances Stem Cell Delivery for Post-mi Cardiovascular Repair .......................................................... 11K. Park, I. Kim, M. Hwang, D. Choi

Modulating Targeting to Ischemic Muscle with Enzyme-Responsive Nanoparticles ............................................................................... 12J. Ungerleider, J. Kammeyer, R. Braden, N. Gianneschi, K. Christman

Platelet-mimicking Therapeutic Nanoparticles for Enhanced Cardiac Repair After Ischemia-Reperfusion Injury ........................... 13T. Su, K. Huang, H. Ma, H. Liang, P. Erb, L. Qiao, D. Shen, M. Hensley, A. Young, T. Allen, A. Vandergriff, P. Dinh, J. Cores, J. Liu, L. Qian, F. Ligler, K. Cheng

ROS, pH and Temperature Responsive Hydrogels for Stem Cell Therapy............................................................................................... 14H. Niu, X. Hu, Z. Huang, Z. Fan, Y. Dang, C. Li, J. Guan

DRUG DELIVERY Visceral Adipose Tissue Macrophage-targeted Gene Delivery for Treating Obesity-induced Type Ii Diabetes .................................. 15

Y Song, S Yong, H Wee, J Chung, Y Kim

Tuning Hydro-phobe Density and Length in an Anionic Polymer for Enhanced In-tracellular Delivery of a CPP-based MAPKAP Kinase II Inhibitor .............................................................................................................................................................. 16

E. Dailing, K. Kilchrist, B. Evans, C. Duvall

Refilling Drug-Eluting Depots through Systemic Administration of Inert Prodrugs............................................................................... 17Y. Brudno, B. Kwee, N. Joshi, M. Aizenberg, D. Mooney

Influence of Formulation on Cyclodextrin Retention and Drug Delivery for Gastrointestinal Luminal Wound Healing ............................................................................................................................................................................................................... 18

N. Rohner, S. Merritt, S. Zuckerman, S. Schomisch, J. Marks, H. Von Recum

Evaluation of Bone Forming Potential of Simvastatin-containing Polymeric Prodrugs .......................................................................... 19N Venkatesan, A Liyanage, J Castro-Núñez, T Asafo-Adjei, T Dziubla, L Cunningham, D Puleo

RhoA Knockdown by PgP/siRhoA Polyplexes Reduces Secondary Injury in a Rat TBI model ............................................................. 20C Macks, S Gwak, D Jeong, M Lynn, J Lee

Engineered Controlled Macromolecular Delivery Scaffold for Rotator Cuff Repair .............................................................................. 21A. Prabhath, V. Vernekar, S. Kumbar, C. Laurencin

Development of a Novel Topical Controlled Re-lease System for Otic Drug Delivery ............................................................................. 22L Bruk, M Fedorchak

DENTAL/CRANIOFACIAL MATERIALS SIG Accelerated Degradation Evaluation of Methacrylate Dental Resins ........................................................................................................ 23

J. Sun, X. Wang

Evaluation of Surface Morphology, Antibacterial Efficacy, and Biocompatibility of Dental Cements in Simulated Oral Environment ............................................................................................................................................................................................ 24

S Gallegos, S Parsaei, J Marvin, D Rodrigues

Regeneration of Tubular Dentin Using Bio-inspired 3D Micropattern ..................................................................................................... 25C. Ma, X. Liu, B. Chang

Novel Hybrid Adhesive Designed with Buffering Capabilities and Autonomous Strengthening............................................................ 26P Spencer, L Song, Q Ye, X Ge, A Misra, C Tamerler

Efficacy of Nitric Oxide-Releasing Hyperbranched Polymers against Ex Vivo Multispecies Dental Biofilms ..................................... 27L. Yang, F. Teles, L. Martin, S. Dua, M. Schoenfisch

Reliability of Dental Zirconia: Effect of Thermal History and Grain Size ................................................................................................ 28I. Denry, M. Abdelaal, J. Holloway

Investigation of Titanium Oxide Characteristics on Healing Abutments: Retrieval Characterization and Soft Tissue Compatibility ........................................................................................................................................................................................ 29

S. Wheelis, A. Montaño, M. Quevedo-Lopez, T. Wilson, P. Valderrama, D. Rodrigues

Synthetic Morphogen Fields for Directed Differentiation of Dental Stem Cells ....................................................................................... 30P Arany, S Rahman

ENGINEERED MICROENVIRONMENTS TO MODEL DISEASE Recapitulating the 3D Microenvironment of the Human Neural Microinterface with the Blood Brain Barrier.................................. 31

S Ahn, J Yom, C Hovell, Y Sei, Y Kim

Electrospun Fibrillar Bioma-terial Platforms with Tunable Mechanics as Fibrosis Disease Models..................................................... 32M. Davidson, K. Song, M. Lee, J. Llewellyn, R. Wells, J. Burdick

Matrix Elasticity Defines Cell Migration Modes in Aligned Fibrous Microenvironments ...................................................................... 33W. Wang, C. Davidson, B. Baker

Non-Invasive Oxygen Monitoring Using Fluorescent Hydrogel Microparticles ....................................................................................... 34R. Wilson, K. Grande-Allen

On Chip Reconstitution of Atherogenic Microenvironment Reveals Frequency-Dependent Endothelial Response............................ 35Y. Sei, S. Ahn, T. Virtue, T. Kimg, Y. Kim

Engineering Cardiac Tissue Mimics as In Vitro Test Beds to Investigate Congenital Heart Disease .................................................... 36D. Bousalis, C. Lacko, R. Wachs, H. Kasahara, C. Schmidt

Biomimetic Microfluidic Networks in Synthetic and Natural Hydrogels for Vessel-on-a-Chip Applications....................................... 37K. Keller, J. Sperduto, J. Slater

Metabolically-Driven Maturation of iPS-Cell Derived Cardiomyocytes in Microphysiological Systems .............................................. 38N Huebsch, B Charrez, B Siemons, K Onishi, S Boggess, F Montiel, N Deveshwar, N Jeffries, A Stahl, E Miller, K Healy

CANCER NANOTECHNOLOGY Disrupting Physical Interactions Between Multiple Myeloma and the Bone Marrow Niche via Nanoparticle-Mediated RNAi ................................................................................................................................................................................................. 39

M Mitchell, R Langer

Targeted Combinatorial Drug Delivery Using Stimuli-Responsive Mesoporous Silica Nanoparticles for Pancreatic Ductal Adenocarcinoma Therapy................................................................................................................................................................... 40

M Tarannum, J Vivero-Escoto

Targeted Anti-Angiogenesis Therapy for Cancer Treatment ..................................................................................................................... 41Y Li, C Mao

T Cell-Engaging Self-Assembled Bispecific Antibody Nanoparticles Against Breast Cancer Cells ....................................................... 42W Lv, J Champion

Nanoparticles Coated with Frizzled7 Antibodies Enable Multivalent Binding for Enhanced Wnt Signaling Inhibition in Triple-Negative Breast Cancer ................................................................................................................................................. 43

R. Riley, E. Day

Using Nucleic Acids to Target Nanoparticles to Drug-Eluting Gels for Local Drug Release .................................................................. 44Y. Brudno, E. Silva, C. Kearney, S. Lewin, A. Miller, K. Martimick, M. Aizenberg, D. Mooney

Nano-Bio Interactions to Enhance the Systemic Circulation Time and Tumor Targeting Efficiency of Nanomedicine in Cancer.................................................................................................................................................................................. 45

S. Kesharwani, P. Muley, A. Ukidve, G. Bhat, S. Mitragotri, H. Tummala

TRAIL-coated Leukocytes to Kill Tumor Cells in the Blood of Prostate Cancer Patients ...................................................................... 46N. Ortiz-Otero, J. Marshall, E. M Messing, D. M. Sahasrabudhe, M. R. King

CONCURRENT SESSION 2 (RAPID FIRE SESSIONS) FABRICATION AND 3D PRINTING OF TISSUE ENGINEERING SCAFFOLDS Evaluation of Chitosan-based Hydrogel as a Bioprinting Material for Vocal Fold Tissue Engineering................................................ 47

G Bao, T Jiang, H Ravanbakhsh, H Wang, J Kinsella, L Mongeau

Response of Bioprinted Neuroblastoma to Electrical Stimulation.............................................................................................................. 48K. Roehm, S. Madihally

Orthogonally Programmable Stiffness and Geometry in 3D Hydrogel Microstructures by Digital Projection Stereolithography ............................................................................................................................................................................................. 49

Y Ding, H Yin, W Tan, X Yin

Stereolithographic 3D Printing of Mechanically Enhanced Constructs for the Treatment of Pediatric Physeal Injuries............................................................................................................................................................................................................... 50

A Uzcategui, Y Yu, A Muralidharan, K Payne, R McLeod, S Bryant

Development of New Binder Jetting Process for Fabricating Bone Regeneration Implants ................................................................... 51M. Watanabe, Y. Tsujimura, S. Oyama, K. Yamazawa, H. Yokota

Stem Cell Niche Generation through Shear Stress, Spatial Patterning of Proliferation, Differentiation, and Cocultures.......................................................................................................................................................................................................... 52

J. Lembong, M. Lerman, T. Kingsbury, C. Civin, J. Fisher

Shape-fitting Mineralized Collagen-PLA Composite for Cranio-Maxillofacial Bone Regeneration...................................................... 53M. Dewey, E. Johnson, M. Wheeler, B. Harley

Manipulating Bioink Chemistry and Mechanical Properties for Long-Term Cell Health After 3D Printing of Gel-Phase Bioinks .................................................................................................................................................................................................... 54

E. Gargus, A. Rutz, K. Hyland, P. Lewis, A. Setty, R. Shah

3D Printing Thermosensitive Polymers: The Development of Filament-Based Direct Writing Melt Electrospinning ........................ 55J. Steele, A. March, J. Molde, J. Kohn

Issues in Fabrication and 3D Printing of Tissue Engineering Scaffolds from Degradable Polymers..................................................... 56S Murthy, J Kohn

Alginate/Gelatin as a Bioprinting Ink to Tailor Tumor Spheroid Formation ........................................................................................... 57T Jiang, J Munguia-Lopez, S Flores Torres, J Kort Mascort, K Gu, M Bavoux, J Kinsella

3D-Printed Polylactic Acid Scaffold for Regenerative Implant Integration Applications ....................................................................... 58E Yenner, K Kumar, D Wetknight, A Neiman, N Wancio, M Frohbergh

Development and Mechanical Characterization of Composite ß-TCP Bioinks For Their Use in Biomedical Applications....................................................................................................................................................................................................... 59

S. Montelongo, G. Chiou, S. Miar, T. Guda

Dipyridamole Enhances Bone Regenerative Capacity of 3D Printed Scaffolds at the Upper Extremity in a Dose Dependent Manner ........................................................................................................................................................................................... 60

L. Witek, C. Lopez, N. Tovar, M. Bowers, B. Cronstein, P. Coelho

An Intrinsic Angiogenesis Approach and Varying Bioceramic Scaffold Architecture Affect Blood Vessel Formation in Bone Tissue Engineering in vivo ............................................................................................................................................. 61

C Knabe, M Kampschulte, B Peleska, R Gildenhaar, G Berger, C Gomes, U Linow, J Guenster, A Houshmand, M Stiller, K Abdel Ghaffar, A Gamal, M El-Mofty, D Adel-Khattab

BIOMATERIALS FOR REGNERATIVE ENGINEERING APPLICATIONS Probing Mechanisms of Matrix Remodeling During Capillary Morphogenesis using Protease-selective Hydrogels .......................... 62

B Juliar, J Beamish, A Putnam

Pre-vascularized Human Mesenchymal Stem Cell Sheets for Full Thickness Skin Wound Repair ....................................................... 63F Zhao, L Chen, Q Xing, M Tahtinen, S Qi

Engineering Patent Vasculature of Decellularized Liver Scaffolds for Transplantation......................................................................... 64F. Meng, F. Almohanna, A. Altuhami, A. Assiri, D. Broering

A Multiscale System for Injectable Co-delivery of EGF and Stem Cells to Treat Ischemic Diseases .................................................... 65H Wang, X He

Encapsulation of Endothelial Colony Forming Cells in Injectable Hydrogel Microspheres for Cell Delivery ..................................... 66Y Tian, W Seeto, R Winter, F Caldwell, A Wooldridge, E Lipke

Synthetic Bioadhesive Matrix Facilitates Satellite Cell Transplantation and Engraftment in Dystrophic Diaphragm....................... 67W. Han, S. Anderson, M. Mohiuddin, Y. Jang, A. García

Therapeutic Potential of Bioengineered Skeletal Muscle with Spatially Patterned Structure and Endothelial Support .............................................................................................................................................................................................................. 68

K Nakayama, M Quarta, P Paine, C Alcazar, V Garcia, O Abilez, N Calvo, C Simmons, T Rando, N Huang

Using Methacrylic Acid Based Biomaterials for Endogenous Repair of Skeletal Muscle........................................................................ 69M Carleton, R Mahou, M Sefton

Methacrylic Acid Based Biomaterials for Peripheral Nerve Regeneration ............................................................................................... 70A Androschuk, R Mahou, I Talior-Volodarsky, M Sefton

Poly(3-Hydroxybutyrate-Co-3-Hydroxy Valerate) Nanofibrous Scaffold for Skin Tissue Engineering................................................ 71A Loordhuswamy, D Sundaramoorthy, A Subramanian, U Krishnan, S Sethuraman

Regenerative Engineering of Bone: In Vivo Evaluation of Next Generation Inductive Graphene-Ceramics ....................................... 72L Daneshmandi, S Gohil, L Nair, A Arnold, B Holt, S Sydlik, C Laurencin

Immobilization of BMP-2 within a Poly(Ethylene Glycol) Hydrogel to Induce Osteogenesis in Serum-Free Conditions.......................................................................................................................................................................................................... 73

M Trombold, S Bryant

Prevascularization of Mesenchymal Stem Cell Sheets for Bone Tissue Regeneration ............................................................................. 74W. Jia, Q. Xing, M. Tahtinen, F. Zhao

Anterior Cruciate Ligament Matrix Inspired by Clinical Application: An In Vivo Assessment ............................................................ 75P. Mengsteab, P. Conroy, M. Badon, H. Kan, L. Nair, C. Laurencin

Ultrasmall Superparamagnetic Iron Oxide Nanoparticles as T1 MRI Contrast Agents in Articular Cartilage Imaging .............................................................................................................................................................................................................. 76

J. Wu, C. Wu, B. Lin, T. Shen, L. Yang, C. Xia, H. Ai

BIOMATERIALS AND SCAFFOLDS FOR INTERFACIAL TISSUE ENGINEERING Biomimetic Hydrogel Supports the Development of Murine Primary Ovarian Follicles Co-cultured with Human Adipose Derived Stem Cells ............................................................................................................................................................................ 77

C. Tomaszewski, H. Zhou, E. Constance, A. Shikanov

Micropatterned Graphene-Incorporated Conductive Hydrogels Produced by Femtosecond Laser Ablation for Potential Skeletal Muscle Tissue Engineering Applications ........................................................................................................................ 78

J. Park, J. Lee

3D Printed Bioactive Ceramic Scaffolds Coated with Dipyridamole Regenerate Vascularized Bone Without Suture Fusion in Alveolar Cleft Defects ..................................................................................................................................................................... 79

C. Lopez, F. Gendy, L. Witek, S. Maliha, R. Flores, L. Cavdar, A. Torroni, J. Bekisz, B. Cronstein, P. Coelho

MSC Spheroid Laden Amorphous Silica Fiber Matrix for Osteochondral Regeneration....................................................................... 80H Kim, M Hu, S Nukavarapu

Extracellular Matrix Paper (ECM-paper) for Construction of Multi-layered Blood Vessel Wall Tissues............................................ 81H. Nakatsuji, M. Matsusaki

Bioinspired Fibrin Microthreads Deliver FGF2 to Guide in vitro Skeletal Muscle and Endothelial Cell Function............................. 82M Carnes, K Castellano, G Pins

PCL-Chitosan-Magnesium Oxide Based Composite Nanofibers for Tissue Engineering Applications................................................. 83U. Adhikari, S. Saudi, S. Jun, N. Bhattarai

Electrospun Poly(ε -caprolactone) Nanofiber Shish Kebabs Mimic Mineralized Collagen Fibrils in Bone .......................................... 84T Yu, M Marcolongo, C Li

Opposing Mineral and Protein Gradients in a Nanofiber Scaffold Promotes Spatial Cellular Response ............................................. 85S Patel, K Schutt, D Qu, A Deymier, S Doty, S Thomopoulos, H Lu

Generation of Rapid In situ Forming Channels within Soft Biomaterials via Biodegradable Fiber Porogens ..................................... 86A Chen, D Puleo

Biologically Inspired Osteoinductive Scaffolds with Drug Eluting Spheres .............................................................................................. 87E. Mondragon, M. Cowdin, F. Taraballi, E. Tasciotti, R. Kaunas

A High-Throughput Microchannel Scaffold Fabrication Technique ......................................................................................................... 88D Shahriari, Y Fink, P Anikeeva

Electrochemical Manipulation of a Cell Monolayer Supported by a Biodegradable Polymeric Nanosheet for Cell Transplantation Therapy................................................................................................................................................................................. 89

H. Kaji, J. Suzuki, N. Nagai, T. Abe

Treatment of Osteoarthritis Using Macrophage-Targeting Hyaluronic Acid Microscaffolds ................................................................ 90S Li, J Zhou, A Hakamivala, Y Huang, W Cong, J Borrelli, L Tang

3D Printing Spatially Organized Scaffolds for Osteochondral Interface Regeneration........................................................................... 91H. Busari, P. Schwarzenberg, P. Camacho, K. Hudson, H. Dailey, L. Chow

DRUG DELIVERY Intestinal Organoids Containing PLGA Nanoparticles for the Treatment of Inflammatory Bowel Diseases....................................... 92

Z. Davoudi, N. Peroutka-Bigus, B. Bellaire, M. Wannemuehler, B. Narasimhan, Q. Wang

Modular Nanoparticle Scaffolds for Tunable Drug Delivery ...................................................................................................................... 93K. Peuler, C. Lin

Epitope-Functionalized Nanoparticles for Entrapment of Autism Auto-Antibody.................................................................................. 94A Bolandparvaz, E Edmiston, K Alvarez, J Van De Water, J Lewis

Tailoring Swelling pH of Poly(Sialic Acid) Micelles Based on Core Hydrophobicity .............................................................................. 95G Pawlish, N Comolli, K Spivack

Chitosan/Poly(lactide) Drug-Loaded Nanoparticles for Delivery of Therapeutic Compounds............................................................... 96S. Deveaux, C. Gomillion

Leukocytes as Mobile Carriers of Anti-Cancer Therapeutics via Bispecific Liposomes.......................................................................... 97Z Zhang, D Liu, N Ortiz-Otero, T Cao, M King

A Polyester-based Phase-separating Platform for Controlling the Kinetics of Combinatorial Therapeutics in Ovarian Cancer ................................................................................................................................................................................................ 98

S Arun Kumar, W Souery, Y Jhan, C Bishop

Folic Acid Modified Halloysite Nanotubes with Tumor Targeting Capability ......................................................................................... 99Y. Luo, D. Mills

Silk Carriers for Local Delivery of Cisplatin: In Vitro Release Kinetics.................................................................................................100B. Yavuz, K. Harrington, J. Coburn, B. Chiu, D. Kaplan

Methacrylation of Chondroitin Sulfate for Drug Delivery Applications .................................................................................................101K. Ornell, J. Coburn, N. Phan, W. Linthicum, D. Lozada

Biodegradable Simvastatin-Containing Polymeric Prodrugs with Improved Drug Release and Their Application as Porous Scaffolds For Tissue Engineering ....................................................................................................................................................102

A Liyanage, N Venkatesan, D Puleo

Synthesis and Characterization of Polyethylene (PEG) Incorporated Hyaluronic Acid Hydrogels for Tissue Engineering .....................................................................................................................................................................................................103

J Kim, J Kim

Sequential Delivery of Ketoprofen and Captopril from a Multilayered Poly(β -amino ester) System for Muscle Repair...............................................................................................................................................................................................................105

N Venkatesan, D Puleo

Multiple Growth Factor Loading Strategy Affects Spatiotemporal Release from Heparin Microparticles........................................106R. Subbiah, L. Krishnan, R. Guldberg

Development of a Bi-Modal, in situ Crosslinking Method to Achieve Multi-Factor Release from Electrospun Gelatin..............................................................................................................................................................................................................107

A Kishan, T Walker, N Sears, T Wilems, E Cosgriff-Hernandez

SUPRAMOLECULAR NANOMATERIALS FOR DRUG DELIVERY, IMAGING, AND IMMUNOENGINEERING Phenylboronic Acid-Grafted Polymer Architectures for Facile and Multifunctional Biomolecule Delivery Into Cancer Cells ....................................................................................................................................................................................................108

J Kim, W Kim

Quantitative Supramolecular Drug Loading for Precise Nanomedicine .................................................................................................109M. Webber

Sequential Release of Nanogels from Polymersomes for Dual Intracellular Delivery of Hydrophilic Cargos ....................................110F Du, E Scott

Bio-Adhesive Polymersome for Localized and Sustained Drug Delivery at Pathological Sites with Harsh Enzymatic and Fluidic Environment Via Supramolecular Host- Guest Complexation ............................................................................................111

M Zhu, K Wei, S Lin, G Li, L Bian

Functionalized Nanocellulose as Stable Supports for Crystallizing Small Molecule Pharmaceuticals ................................................112M Banerjee, L Willows, B Brettmann

CuS-Based Theranostic Micelles for NIR-Controlled Combination Chemotherapy and Photothermal Therapy, and Photoacoustic Imaging ...................................................................................................................................................................................113

G. Chen, B. Ma, Y. Wang, R. Xie, C. Li, K. Dou, S. Gong

Surface Engineered Cerium Oxide Nanoparticles Show Promise for Targeting CD44 Expressing Cancer Cells ..............................114M Lord, J Whitelock, K Sutradhar

Magnetic Nanoparticle Thermal Treatment Potentiates Paclitaxel Activity in Breast Cancer Cells ...................................................115A Rivera-Rodriguez, A Chiu-Lam, V Morozov, A Ishov, C Rinaldi

Leukocyte-based Biomimetic Nanoparticles As a Targeted Drug Delivery Vehicle for Triple-negative Breast Cancer ..............................................................................................................................................................................................................116

M Sushnitha, J Martinez, K Hartman, M Evangelopoulos, E Tasciotti

Supramolecular Nanotherapeutics for Preferential Immune Modulation of the Tumor Microenvironment .....................................117A. Kulkarni, S. Natarajan, V. Chandrasekar, S. Sengupta

Multiplexing Antibodies in vivo using Z15_EAK, an Fc-Binding Gelation Module...............................................................................118N. Pham, W. Liu, E. Gawalt, Y. Fan, W. Meng

HER2 – Mediated Targeting of an Intracellular Antibody Delivery System to Breast Cancer Cells...................................................119A. Dhankher, C. Lukianov, J. Champion

Development of Bone-Targeted Nanocarriers for Delivery of Gli-Inhibitor to the Bone Microenvironment .....................................120J. Vanderburgh, M. Gupta, S. Wang, A. Merkel, J. Sterling, C. Duvall, S. Guelcher

Guiding Nanomaterials to Tumors for Breast Cancer Precision Medicine: from Tumor-targeting Small Molecule Discovery to Targeted Nano-drug Delivery .................................................................................................................................................121

P Qiu, C Mao

Phage Enabled Ultrasensitive Direct Detection of Circulating Microrna Biomarker in Human Plasma ............................................122Y Zeng, C Mao

ENGINEERED BIOMATERIALS FOR NEURAL APPLICATIONS Perfusion Stabilizes Long-Term Barrier Function of iPSC-derived Brain Endothelial Cells in 3D Hydrogel Channels ..........................................................................................................................................................................................................123

S Faley, E Hollmann, J Wang, A Bosworth, C Weber, E Lippmann, L Bellan

Transient Blood Brain Barrier Disruption Extends Therapeutic Window for Nanoparticle After Brain Injury ..............................124V. Bharadwaj, T. Anderson, J. Lifshitz, V. Kodibagkar, S. Stabenfeldt

Electrospun Fibers for Application in Neural Tissue Engineering under Controlled Release..............................................................125J Xue, Y Xia

Mechanical Properties and PDGF-AA Release Kinetics of a 3D Hydrogel-Microparticle Drug Delivery System Guide Oligodendrocyte Precursor Cell Prolifera-tion and Differentiation .............................................................................................126

M. Pinezich, L. Russell, N. Murphy, K. Lampe

Drug Loaded Polymer Scaffolds for Treatment of Post-Surgical Glioblastoma .....................................................................................127E Graham-Gurysh, K Moore, E Bachelder, C Miller, S Hingtgen, K Ainslie

Subcutaneous Maturation of Adult NSC-Loaded Biomaterial Scaffolds to Spinal Cord Regionalized Neuroepithelium .............................................................................................................................................................................................128

M Farrag, N Leipzig

A Biomaterial for the Prevention of Epidural Fibrosis ..............................................................................................................................129S Ing, M Cooke, C Tator, M Shoichet

Sulfated Chondroitin Sulfate Glycosaminoglycan Hydrogel Carriers Improve Transplanted Cell Survival and Enhance Regeneration after Ischemic Stroke in Mice ............................................................................................................................... 130

M. McCrary, K. Jesson, G. Sethaputra, X. Gu, L. Karumbaiah, S. Yu, L. Wei

Polyvinylpyrrolidone (PVP) Dexamethasone Controlled Release for Treatment of Neural Inflammation After CNS Injury ...............................................................................................................................................................................................................131

J Johnson, T Zhao, R Saigal

Addressing the Effect of DNase Treatment on ECM Preservation and Cell Removal during Sodium Deoxycholate Based Chemical Decellular-ization of Peripheral Nerve ............................................................................................................................132

M. (Mertz) McCrary, N. Vaughn, Y. Song, C. Schmidt

Freeze-cast Core-shell Scaffolds for 10 mm Peripheral Nerve Repair in Rats Sciatic Model ...............................................................133K. Yin, P. Divakar, J. Hong, K. Moodie, J. Rosen, M. Matthew, U. Wegst

Optimizing Schwann Cell Migration Using Laminin Derived-peptides to Improve Nerve Regeneration ...........................................134C. Motta, R. Willits, M. Becker

Scaling Implants From in vivo Models to Clinical Relevance for Peripheral Nerve Repair .................................................................135K Pawelec, J Koffler, A Galvan, M Tuszynski, J Sakamoto

Preparation and Characterization of Magnetically Templated Hydrogels for Peripheral Nerve Injury Repair ...............................136I Singh, C Lacko, C Schmidt, C Rinaldi

Development of an Injectable Device for Peripheral Nerve Repair..........................................................................................................137T Prest, C Skillen, C Heisler, K Labelle, R Hartogs, B Brown

ORTHOPAEDIC BIOMATERIALS Metal-Protein Degradation Products Mediated Neural Cell Defects due to S-phase Arrest .................................................................138

D Bijukumar, A Segu, Y Mou, X Li, P Chastain, M Mathew

Direct Detection of Fluorescently-Tagged Reactive Oxygen Species on a Cathodically-Biased Metallic Surface ..............................139M. Wiegand, J. Gilbert

Local and Distant Organ Tissue Responses to Corrosion of Modular Head-Neck Junctions Retrieved Postmortem .......................140D Hall, R Pourzal, J Wright, S McCarthy, J Jacobs, R Urban

In Vitro and In Vivo Studies on Biomedical Magnesium Low-alloying with Elements Gadolinium and Zinc ...................................141Y Zheng

Development and Characterization of Metastable β-Ti Alloys for Biomedical Applications ................................................................142C Grandini, P Kuroda, M Lourenço, G Cardoso, B Pedroso, I Rodrigues, K Sousa, T Donato

Fabrication of a Free Radical Scavenging Nanocomposite Scaffold for Bone Tissue Regeneration ....................................................143K. Dulany, A. Kelley, J. Allen

In Vitro Evaluation of a UV-Cured Gelatin-Nano-Hydroxyapatite Composite System Using MG63 Cells ........................................144P. Comeau, P. Hamilton, S. Mohammadi, M. Gorbet, T. Willett

Hyaluronic Acid Silica Sol-gel Nano-hybrids by Biomimetic Approach..................................................................................................145H. Lee, H. Kim

Zero-current Growth of Bone-Like Mineral on Inert Substrates using Electric-Field-Induced Surface Charge ..............................146J Vincelli, I O’Donnell, A Alsasa, S Kennedy

Manipulation of Methacrylated Gelatin Viscosity, UV-Curing Depth and Swelling Behavior by the Controlled Addition of Calcium and Citrate Salts .........................................................................................................................................................147

P. Comeau, T. Willett

Conformity and Stability in Total Knee Replacements..............................................................................................................................148M. Bebler, L. Young, N. Meilinger, M. Harman

In Vitro Wear and Particle Analysis Evaluation of Highly Cross-Linked UHMWPE and Vitamin E UHWMPE Thin Acetabular Liners and its Biological Effects ......................................................................................................................................149

S Nambu, G Hines, D Chang

Friction and Lubricant Response of the Micro-Textured Carbide-Cocrmo Alloy Surface on Various Wear Couple Systems.............................................................................................................................................................................................................150

G Ettienne-Modeste

Rolled PCL/GelMA Composites as Scaffolds for ACL Repair .................................................................................................................151H Kenawy, M Earley, D Gadalla, A Goldstein

Use of Novel Collagen Yarns in a Woven Patch Graft for Rotator Cuff Repair.....................................................................................152Y. Xie, O. Akkus, E. Cadet, M. King

ENGINEERED MICROENVIRONMENTS TO MODEL DISEASE Development of a Three-Dimensional Collagen Model for the In Vitro Evaluation of Osteogenesis ...................................................153

R Yuan, K Memarzadeh, A Stephen, R Allaker, J Huang

A 3D in vitro Osteoarthritis Model to Evaluate the Therapeutic Potential of Human Mesenchymal Stem Cells ..............................154P Diaz-Rodriguez, H Chen, S Samavedi, M Hahn

The Role of Mechanotransduction on Myoblasts in Muscle Injury Using Dynamically Stiffening Polymers .....................................155J. Silver, T. Brown, T. Vogler, F. Delrio, A. McKay, B. Olwin, K. Anseth

Mimicking Paracrine Signals between Macrophages and Fibroblasts in a 3D Wound Healing Model in vitro .................................156F. Ullm, M. Ansorge, J. Sapudom, K. Franke, T. Pompe

Engineering of an In Vitro Model of Discogenic Low Back Pain..............................................................................................................157S. Romereim, E. Johnson, R. Wachs

Mechanobiologically-Modulated Microniches for Investigation of Angiogenesis Induced Liver Fibrosis and Drug Testing..............................................................................................................................................................................................................158

L. Liu, Z. You, H. Yu, L. Zhou, H. Zhao, X. Yan, D. Li, B. Li, B. Wang, L. Zhu, Y. Xu, T. Xia, Y. Shi, C. Huang, W. Hou, Y. Du

Matrix Adhesivity and Stiffness Regulate Metastatic Breast Cancer Dormancy ...................................................................................159S. Pradhan, M. Chatterjee, J. Slater

Fibrous Topography Promotes Cell Spreading and Migration In 3D......................................................................................................160D Matera, B Baker

Synthetic Hydrogels with Highly Bioactive Basement Membrane Functionality ...................................................................................161R. Wilson, G. Swaminathan, K. Grande-Allen

Decoupling the Impact of Hydrogel Stiffness and Mesh Size for Studying Matrix Metalloproteinase-Mediated Behavior of Metastatic Breast Cancer Cells ................................................................................................................................................162

A. Narkhede, S. Rao

Biomaterials Models of Glioblastoma Microenvironment.........................................................................................................................163W Xiao, A Sohrabi, Y Ghochani, A Ehsanipour, R Zhang, S Sun, L Ta, H Kornblum, D Nathanson, S Seidlits

Polymer Scaffolds for Early Detection and Vaccination Against Metastatic Breast Cancer ................................................................164Y. Zhang, K. Hughes, R. Oakes, G. Bushnell, R. Hartfield, M. Cascalho, J. Platt, J. Jeruss, L. Shea

In Vitro Bioengineered Prostate Tumor Model for Recapitulation of the Native Tumor Microenvironment ....................................165N. Habbit, B. Anbiah, I. Hassani, M. Eggert, S. Jasper, B. Prabhakarpandian, R. Arnold, E. Lipke

Three-Dimensional Engineered Tumor Tissues Using Patient-Derived Colorectal Cancer Xenografts ..............................................166I Hassani, B Anbiah, B Ahmed, N Habbit, M Greene, E Lipke

Effect of 3D Porous Chitosan-Alginate Scaffold Stiffness on Prostate Cancer Malignancy ..................................................................167K. Xu, K. Ganapathy, T. Andl, Z. Wang, J. Copland, R. Chakrabarti, S. Florczyk

CONCURRENT SESSION 3 BIOMATERIALS TECHNOLOGIES FOR PRECISION MEDICINE Leveraging Multifunctional (nano) Biomaterials for Precision Cancer Therapy .................................................................................. N/A

Natalie Artzi

Injectable, MMP-Responsive Hydrogels for On-Demand Sirna Delivery After Myocardial Infarction .............................................168L Wang, J Chung, S Uman, P Atluri, J Burdick

Biomaterial Scaffolds Recruit an Aggressive Population of Metastatic Tumor Cells in vivo................................................................169G. Bushnell, T. Hardas, R. Hartfield, Y. Zhang, R. Oakes, J. Jeruss, L. Shea

Smart Contact Lens for Real-Time Glucose Monitoring and Wirelessly-Controlled Drug Delivery...................................................170S Hahn

Development of a High Throughput 3D Biomaterials Platform to Measure Protease Activity in Breast Cancer Patients.............................................................................................................................................................................................................171

A. Fakhouri, J. Weist, A. Tomusko, L. Yee, J. Leight

Magnetically Responsive Hydrogels for Optimizing Anticancer Therpeutic Delivery Profiles ............................................................172T Emi, T Barnes, E Orton, A Reisch, Z Silveira, A Tolouei, S Kennedy

The Molecular Signature of a Synthetic Pre-Metastatic Niche for Prediction of Metastatic Potential ................................................173R. Oakes, G. Bushnell, J. Decker, Y. Zhang, R. Hartfield, P. Lafaire, P. Kandagatla, J. Jeruss, L. Shea

THE CONVERGENCE OF ADVANCED MATERIALS WITH DEVELOPMENTAL BIOLOGY Biomaterials to Support and Guide Vascularization................................................................................................................................. N/A

Jennifer West

Nonviral Direct Conversion of Fibroblasts to Neuronal Cells Using Polydopamine-coated Nanofibril Scaffold ...............................174H Kim, H Kim, K Leong

Controlling Osteogenic Differentiation of hMSCs Encapsulated in Thiol-Epoxy Crosslinked PEG-based Hydrogels......................175C Huynh, F Liu, Y Cheng, K Coughlin, E Alsberg

Biomedical Applications of Magnetic Nanoparticles for Regenerative Medicine ...................................................................................176J Dobson

Tissue Origami for Regenerative Engineering ............................................................................................................................................177G. Camci-Unal

Dynamic Transcription Factor Activity Networks in Response To Ovarian Follicle Culture Environments .....................................178H. Zhou, J. Decker, C. Tomaszewski, L. Shea, A. Shikanov

Tunable Synthetic PEG Hydrogels for Supporting Lymphangion Sprouting Lymphangiogenesis .....................................................179J Hooks, R Cruz-Acuña, A García, J Dixon

NANO DRUG DELIVERY S-nitrosated Poly(Propylene Sulfide) Nanoparticles for Enhanced Nitric Oxide Delivery to Lymphatic Tissues and Lymph Node-resident Cells ...........................................................................................................................................................................180

A Schudel, L Sestito, S Thomas

Supramolecular PEGylation as an Innovative Approach to Biopharmaceutical Formulation and Delivery......................................181E Appel, C Maikawa, G Agmon

Galectin-8 Imaging Demonstrates Endosomal Disruption by Nanocarrier and Predicts Biologic Drug Intracellular Bioavailability .................................................................................................................................................................................................182

K. Kilchrist, S. Dimobi, T. Werfel, E. Dailing, M. Jackson, C. Duvall

Efficient Gene Editing Using a Bioegradable Nanocapsule Containing Cas9 Ribonucleoprotein ........................................................183A. Abdeen, G. Chen, P. Shahi, R. Xie, B. Pattnaik, S. Gong, K. Saha

Optimization and Comparison of CD4-targeting Lipid-Polymer Hybrid Nanoparticles Using Different Binding Ligands.............................................................................................................................................................................................................184

S. Cao, Y. Jiang, C. Levy, S. Hughes, H. Zhang, F. Hladik

Engineered Extracellular Vesicles with Synthetic Lipids via Membrane Fusion to Establish Efficient and Targeted Drug and Gene Delivery ................................................................................................................................................................................185

Y. Jhan, D. Moore, S. Arun Kumar, C. Bishop

Development of Layer-by-Layer Assembled Nanoshells for Intracellular miR-34a Delivery ...............................................................186R. Goyal, E. Day

NIR Triggered Photodynamic/Chemotherapy in Combination with Immunotherapy by Using Cascade Upconversion Nanoparticles for Elimination of Primary Tumor and Remission of Metastasis ...........................................................187

J. Chen

RACING FOR THE SURFACE: RECENT DEVELOPMENT IN ANTIMICROBIAL AND OSTEOINDUCTIVE BIOMATERIALS In vitro Competition of Oral Mammalian Cells and Early Oral Colonizers On Titanium Substrates ................................................188

W. Huo, K. Palmer, S. Wheelis, D. Rodrigues

Antimicrobial Activities of Conventional and Novel Antimicrobial Agents against S. aureus Biofilms ..............................................189J. Kang, B. Li

Nanosilver Dopped Nanosilica and RGD Mimetic Hydrogel Repairing Infected Bone Defect .............................................................190M Xing, S Zhang, Q. Yuan

Nanopatterning of Bacterial Nanocellulose and Polydimethylsiloxane for Anti-biofouling Polymeric Interfaces .............................191S Arias, J Devorkin, M Cheng, C Jaramillo, A Civantos, J Allain

Evaluation of Two Different Neutralization Methods for Chitosan Coatings .........................................................................................192K. Patel, J. Bumgardner

Enhancing Design of Anti-Biofilm Drug Delivery Nanoparticles via High Throughput Screening .....................................................193K Sims, Y Liu, P Dunman, H Koo, D Benoit

BIOMATERIALS TISSUE INTERACTION SIG High Resolution Single-Cell Correlative Microscopy of Glial Cell Interactions with Artificial Axons................................................194

A. Merolli, Y. Mao, J. Steele, V. Manichev, S. Fung, D. Martin, M. Li, P. Moghe, L. Feldman, T. Gustaffson, C. Dreyfus, J. Kohn

Biological Responses and Mechanisms of Human Bone Marrow Mesenchymal Stem Cells to Zn and Mg Biomaterials ....................................................................................................................................................................................................195

D. Zhu, Y. Su, Y. Zheng, L. Tang

Foreign Body Response Mitigation and Tissue Integration in Morphologically Unique Bijel-Templated Hydrogel Implants ...........................................................................................................................................................................................................196

T Thorson, E Botvinick, A Mohraz

“How You Form it Matters”: Processing Techniques of Implant Polymers Differentially Impact Vascular Cell Behavior...........................................................................................................................................................................................................197

K Ammann, M Li, M Slepian

Immunostimulatory Microgels for Potential Immune Cells Recruitment and Activation ....................................................................198M. Rezaeeyazdi, T. Colombani, S. Bencherif

In Vivo Comparison of Polydioxanone and Polyhydroxyalkanoate Barbed Surgical Sutures in a Rat Model ...................................199H Cong, G Ruff, J Cole, D Tokarz, S Roe, W Liu, M King

Influence of Surface Charge On Host Response to Implanted Biomaterials ...........................................................................................200G. Kokil, D. Nguyen, A. Dao, T. Dang

Alternative Foaming Agents for Topical Treatment of Ulcerative Colitis ...............................................................................................201M. Asama, A. Hall, Y. Qi, B. Moreau, H. Walthier, M. Schaschwary, B. Bristow, Q. Wang

IMMUNE ENGINEERING Ex Vivo Immune Organoids to Model Epigenetics and Transcriptional Feed-back Loop in Humoral Immunity.............................202

A. Singh, W. Beguelin, A. Purwada, A. Melnick

Multi-Niche Human Bone Marrow-on-a-Chip for Studying Hematopoietic Stem Cell Dynamics .......................................................203M. Nelson, A. Krishnan, K. Roy

Biomaterial Nanoparticles Redistribute Therapeutic Antibodies to Lymph Node-Resident Cells to Enhance Cancer Immunotherapy Via Checkpoint Inhibition................................................................................................................................................204

D Francis, A Schudel, N Rohner, S Thomas

Combination Nanovaccine Induces Rapid and Long-lived Protective Immunity against Yersinia pestis ...........................................205S Kelly, D Wagner-Muniz, N Peroutka-Bigus, T Dubensky, B Bellaire, M Wannemuehler, B Narasimhan

An Antigen-Specific Microparticle System Blocks Experimental Autoimmune Encephalomyelitis ....................................................206J. Stewart, J. Cho, T. Drashansky, M. Brusko, A. Zuniga, K. Lorentsen, D. Avram, B. Keselowsky

Harnessing Long-Term Release to Produce Robust Long-term Immunity .............................................................................................207E Appel, G Agmon, A Yu

Targeted Extracellular Delivery of Indoleamine 2,3-Dioxygenase Via Fusion with Galectin 3 Ameliorates Inflammation in Vitro and in Vivo ...............................................................................................................................................................208

E Bracho-Sanchez, K Koenders, A Restuccia, M Fettis, M Wallet, F Rocha, S Wallet, G Hudalla, B Keselowsky

Characterization of the Immune Response to Biomaterial-Mediated Infection Following Trauma ....................................................209C. Vantucci, H. Ahn, M. Schenker, P. Pradhan, K. Roy, R. Guldberg, N. Willett

CONCURRENT SESSION 4 *BTI* FROM CONCEPTION TO CLINICAL TRIAL: EXAMPLES OF TECHNOLOGY DEVELOPMENT Development of a Sprayable Biopolymer Hydrogel for the Prevention of Postoperative Adhesions ...................................................210

L Costella, M Patterson, B Janet, P Cottler, C Tison

Translation of a Crosslinked Hyaluronic Acid Gel for Corneal Repair from the Bench to Veterinary and Human Medicine ..........................................................................................................................................................................................................211

B. Mann, S. Atzet, B. Wirostko

3D Bioprinting Personalized Neural Tissues For Drug Screening Applications .....................................................................................212M. Robinson, L. Abelseth, S. Singh, C. Blood, S. Wadsworth, S. Willerth

High Throughput Solution Deposited Hydroxyapatite Coatings for Orthopedic Implants ..................................................................213C. Ernsberger, S. Vass, B. Smith, J. Langhorn, H. Qu, D. Ettensohn, R. Kasinath

INTELLIGENT HYDROGELS FOR BIOMEDICAL APPLICATIONS JOINT SYMPOSIUM WITH KOREAN SOCIETY FOR BIOMATERIALS Hydrogen Peroxide-Controllable Hydrogels For Vascular Tissue Regeneration ...................................................................................214

Y Lee, J Son, J Kang, K Park

Covalently Tethering Transfection-Capable siRNA to Hydrogels for Sustained Release and Gene Silencing ...................................215C Huynh, M Nguyen, A Gilewski, S Wilner, K Maier, N Kwon, M Levy, E Alsberg

Spatiotemporal Control Over Intestinal Organoid Formation in Photodegradable Hydrogels............................................................216T. Brown, N. Gjorevski, M. Lutolf, K. Anseth

Self-folding of Multi-Layered Hydrogel Designed for Biological Machine..............................................................................................217S Cho, S Shin, H Kim, S Han, J Jeong

Molecular Modeling to Predict Peptide Accessibility for Peptide-Functionalized Hydrogels ...............................................................218X. Li, J. Jia, Y. Mei, R. Latour

THE PRECLINICAL AND CLINICAL EXPERIENCE WITH REGENERATIVE BIOMATERIALS Degradable, “Self-fitting” Shape Memory Polymer SMP Scaffolds for Cranial Bone Defect Repair..................................................219

M Grunlan, L Woodard, A Roth, K Kmetz, V Page

Stem Cell Seeded Biomimetic Nucleus Pulposus and Annulus Fibrosus Implants Promote Living Repair of Degenerative Intervertebral Discs in Sheep ................................................................................................................................................220

R. Borem, J. Walters, A. Madeline, L. Madeline, S. Gill, J. Mercuri

A Thermoresponsive, Citrate-based Macromolecule for Bone Regenerative Engineering ...................................................................221S. Morochnik, Y. Zhu, C. Duan, M. Cai, R. Reid, T. He, J. Koh, I. Szleifer, G. Ameer

Tetrazine Click-Mediated Functionalization and Assembly of Microgel-Based Scaffolds for Tissue Engineering ............................222F. Jivan, D. Alge

Bio-inspired Design of a Retrievable and Scalable Cell Encapsulation Device for Potential Treatment of Type 1 Diabetes............................................................................................................................................................................................................223

M. Ma

Decellularized Extracellular Matrix Microparticles Seeded With Bone Marrow Mesenchymal Stromal Cells For Treatment Of Full-Thickness Cutaneous Wounds .....................................................................................................................................224

A. Westman, R. Goldstein, G. Bradica, S. Goldman, M. Randolph, J. Gaut, J. Vacanti, D. Hoganson

IMPLANTABLE BIOELECTRONICS Biodegradable Piezoelectric Force Sensor For Monitoring Biological Pressures ...................................................................................225

T Nguyen, E. Curry

Plug-and-Play Mesh Electronics with Nanowire Field-Effect Transistor Sensors for In Vivo Bio-Nano Interfacing ........................226T. Schuhmann, J. Yao, G. Hong, T. Fu, C. Lieber

Silk-Inspired Neurotechnology: Soft, Flexible and Conformal Silk Electrode Interfaces for The Peripheral Nerve.........................227A Patil, N Thakor

In Situ Polymerized Neural Interfaces for Peripheral Nerve Recording and Stimulation ....................................................................228J. Murbach, Y. Tong, V. Subramanian, S. Chhatre, B. Johnson, D. Martin, K. Otto

Neural Interfacing with a Microfluidic Ion Pump ......................................................................................................................................229C. Proctor, A. Slezia, A. Williamson, G. Malliaras

Melatonin Injection Improves Quality and Longevity of Chronic Neural Recording............................................................................230A. Golabchi, B. Wu, T. Kozai, X. Cui

BIOMATERIALS TECHNOLOGIES FOR HEMOSTATIS AND WOUND CARE SynthoPlateTM: An Intravenous Synthetic Hemostat for Pre-hospital Treatment of Traumatic Hemorrhage...................................231

C Pawlowski, D Hickman, N Luc, M Dyer, A Shevitz, A Kim, M Neal, V Kashyap, A Sen Gupta

Supplementing Coagulation Factor XIIIa and a Synthetic Polymeric Substrate of Factor XIIIa Recovers Clot Adhesion of Fibrin-Poor Blood .....................................................................................................................................................................232

K. Chan, C. Zhao, E. Siren, J. Chan, J. Boschman, J. Yeon, C. Kastrup

Wound Targeting Fibrinolytic Nanogels for Treating Disruptive Widespread Clot Activation...........................................................233E. Mihalko, N. Mininni, A. Brown

Laser-Activated Tissue Integrating Sutures LATIS for Rapid Wound Closure.....................................................................................234D. Ghosh, R. Urie, J. Kilbourne, J. Lee, K. Rege

Adipose Derived Stem Cells Combined with an Advanced Collagen Wound Matrix for Treatment of Chronic, Non-Healing Diabetic Skin Wounds.............................................................................................................................................................235

N. Edwards, W. Friedrichs, D. Feliers, R. Christy, R. Stone, Q. Zhao, X. Cheng

Silk Nanosealants for Laser-Activated Tissue Repair ................................................................................................................................236R Urie, D Ghosh, C Guo, J Kilbourne, J Lee, J Yarger, K Rege

NEXT GENERATION BIOMATERIALS FOR ISLET DELIVERY AND IMMUNE ACCEPTANCE FOR DIABETES Design of Degradable PEG Hydrogels to Deliver CCL21 and β Cell Autoantigens for the Induction of Peripheral Tolerance In Type 1 Diabetes........................................................................................................................................................................237

S Zustiak, A Tomei, D Velluto, M Abreu, A Stock

The Timing is Crucial for Adequate Blood Perfusion of an Artificial Subcutaneous Site for Pancreatic Islet Transplantation ..............................................................................................................................................................................................238

A. Patikova, L. Kosinova, A. Vojtiskova, E. Sticova, J. Kriz

Enzymatic Peptide Ligation for in situ Encapsulation and Delivery of Pancreatic Islets ......................................................................239M Arkenberg, C Lin

Clinically Translatable Immunomodulatory Cytokine Eluting Alginate Microbeads containing Neonatal Porcine Islet-like Clusters for the Treatment of Type 1 Diabetes ...........................................................................................................................240

P Varde, J Hutcheson, K Buac, J Cano, B Denney, K Grooms, C Seawell, R Rodriguez, M Poznansky, S McCormack, S Chavan

Subcutaneous Transplantation of Reconstituted Pseudo-Islets to Restore Normoglycemia in Diabetic SCID/bg Mice ..................................................................................................................................................................................................................241

A Vlahos, S Keshavjee, S Kinney, A Martyts, M Sefton

Microfluidic Polyethylene glycol-based Islet Encapsulation Enables Transplantation in Highly Vascularized Site..........................242J Weaver, D Headen, M Coronel, M Hunckler, A Garcia

CONCURRENT SESSION 5 *BTI* TESTING METHODS FOR EVALUATING TRANLATIONAL BIOMATERIALS Physiochemical Characterization and Biocompatibility of Ionic Dimethacrylates for Dental Restorations .......................................243

D. Bienek, S. Frukhtbeyn, U. Okeke, A. Giuseppetti, R. Pires, J. Antonucci, D. Skrtic

Multiscale Tuning and Classification of Biological Cell Confinement in Fibrous Microenvironments ...............................................244F. Tourlomousis, C. Jia, H. Wang, D. Kalyon, R. Chang

Sarcomeric Addition in an Aligned Myocyte Culture Model Visualized by SHG Confocal Microscopy ............................................245Z. Wang, A. Wei, X. Yang, S. Ma, B. Thomas, B. Gao

Application of Electrochemical Sensors to Study Dental Composites ......................................................................................................246D. Koley, G. Ummadi, S. Aponso, H. Davis, J. Ferracane

Novel Testing Methodology for Chemical Durability of Ceramics Used in the Oral Cavity .................................................................247J Esquivel-Upshaw, F Ren, S Hsu, F Dieng, D Neal, A Clark

Using Simultaneous Measurements During Photopolymerization to Measure Relaxation Time Growth and Connection to Network Clustering ...............................................................................................................................................................248

S. Sarkar, S. Lin-Gibson, M. Chiang

Biocompatibility and Suitability of FDM Additive Manufacturing Filaments for use in Tissue Engineering Scaffolds...........................................................................................................................................................................................................249

M. Taylor, B. Gaerke, B. Johns

Non Destructive Monitoring of 3D Cultures of MSC Based on Shifting Metabolism ............................................................................250V. Sikavitsas, A. Simmons

TRANSLATION OF NANOPARTICLE CONTRAST AGENTS FOR CLINICAL X-RAY IMAGING MODALITIES An all-in-one Nanoparticle (AION) Contrast Agent For Breast Cancer Screening With DEM-CT-MRI-NIRF Imaging ............................................................................................................................................................................................................251

J. Hsu, P. Naha, K. Lau, R. Hastings, P. Chhour, J. Stein, W. Witschey, A. Maidment, D. Cormode

A Spectral Library of Nanoparticle Contrast Agents for Molecular Imaging with Computed Tomography .....................................252T. Curtis, P. Nallathamby, R. Roeder

Dextran Coated Cerium Oxide Nanoparticles (Dex-Cenp): A Novel Blood Pool CT Contrast Agent .................................................253P. Naha, S. Singh, D. Cormode

Synthesis, Characterization and Pre-clinical Evaluation of Iodinated Polymer Nanoparticles as a Contrast Agent for Computed Tomography using a Spectral Photon Counting CT .........................................................................................................254

J. Balegamire, Y. Chevalier, H. Fessi, M. Vandamme, E. Chereul, S. Si-Mohamed, L. Boussel, P. Douek

In Vivo Detection of Cancer Stem Cells by Dual Mode CT/ Fluorescence Using Immunotargeted Nanoparticle Probes...............................................................................................................................................................................................................255

P Nallathamby, K Dahl, R Roeder

BIOMATERIALS AND SCAFFOLDS FOR INTERFACIAL TISSUE ENGINEERING Spatiotemporally Controlled Transgene Expression in Hydroxyapatite-Doped Fibrin Scaffolds Using High Intensity Focused Ultrasound .......................................................................................................................................................................256

A. Moncion, J. Harmon, Y. Li, O. Kripfgans, J. Stegemann, F. Martín-Saavedra, N. Vilaboa, R. Franceschi, M. Fabiilli

Direct Fabrication of Cell-Loaded Nanofibrous Hydrogel Scaffolds Using Reactive Electrospinning ................................................257F. Xu, M. Dodd, H. Sheardown, T. Hoare

A Continuous Pore Size Gradient PLLA Scaffold for Osteochondral Regeneration Tested in a Biphasic Bioreactor ......................258R. Gottardi, G. Conoscenti, P. Alexander, V. La Carrubba, V. Brucato, R. Tuan

Dynamic Biointerfaces Based On Sulfonated Polyrotaxanes for Enhancing Osteogenic Differentiation ............................................259Y. Arisaka, N. Yui

Manufacturing Gradient Fibers using Magnetically-Assisted Electrospinning for Interfacial Tissue Engineering ..........................260R. Tindell, M. Le, A. Gualtieri, J. Holloway

Triphasic Biomaterial for Enhanced Toughness and Regeneration of the Osteotendinous Junction ..................................................261R Sun Han Chang, C Lee, S Rogers, B Harley

SUPRAMOLECULAR NANOMATERIALS FOR DRUG DELIVERY, IMAGING, AND IMMUNOENGINEERING Protein Mimetic and Anticancer Properties of Monocyte-targeting Peptide Amphiphile Micelles......................................................262

C. Poon, S. Chowdhuri, C. Kuo, Y. Fang, F. Alenghat, D. Hyatt, K. Kani, M. Gross, E. Chung

Crosslinked Peptide Nanoclusters for Efficient Delivery of Cancer Antigen ..........................................................................................263A Tsoras, J Champion

H2O2-Activatable Contrast-Enhanced Photoacoustic Imaging and Antithrombotic Therapy using Molecularly Engineered Theranostic Nanoparticles ........................................................................................................................................................264

D Lee, E. Jung, C. Kang, D. Yoo

Multi-stage Lymphatic Delivery System Augments Lymphoma Immunotherapy .................................................................................265A. Schudel, C. Higginson, M. Yau, M. Finn, S. Thomas

Galectin-enzyme Fusion Nanoassemblies for Prolonged Injection Site Biocatalysis Via Local Glycan Binding ................................266S Farhadi, E Bracho-Sanchez, S Freeman, B Keselowsky, G Hudalla

Self-Assembling Nanoparticles with Enhanced Stability ...........................................................................................................................267H Acar, G Benuska, L Ludwig, J Labelle, M Tirrell

Amphiphilic Micelle-Mediated Silencing of MGMT in Glioblastoma Multiforme Tumor Cells In Vivo ............................................268A Alexander-Bryant, B Hourigan, M Lynn, J Lee

Nanoscale Peptide Self-assemblies Boost BCG-primed Cellular Immunity Against Mycobacterium Tuberculosis ..........................269C Chesson, R Nusbaum, M Huante, J Endsley, J Rudra

ORTHOPAEDIC BIOMATERIALS SIG Perfusion Driven 3D Bone Mineral Formation ...........................................................................................................................................270

S Sawyer, S Shridhar, K Zhang, L Albrecht, J Horton, P Soman

Assessing if Bone Ingrowth is Affected by Silicone as a Carrier to Deliver Antimicrobials for the Treatment of Periprosthetic Infections ................................................................................................................................................................................271

N Taylor, R Epperson, B Kawaguchi, D Williams

Silk Fibroin/ Elastin Bioinks for 3D Printing of Implants Respecting the Patient Intervertebral Disc Anatomy ..............................272J. Costa, J. Silva-Correia, V. Ribeiro, A. Da Silva Morais, J. Oliveira, R. Reis

Identification of Implant Wear and Corrosion Products within Joint Capsule Tissue by Means of FTIR Imaging..........................273S. Liu, D. Hall, S. McCarthy, J. Jacobs, R. Urban, R. Pourzal

Novel Injectable Newberyite Based Non-exothermic Orthopedic Cements with High Early Strength................................................274N. Rostami, E. Babaie, V. K. Goel, S. B. Bhaduri

Effect of Compliant Layers in Piezoelectric Composite Energy Harvester for Spinal Fusion Applications .......................................275E Krech, E Cadel, K Tong, K Coates, L Lapierre, E Friis

ENGINEERING CELLS AND THEIR MICROENVIRONMENTS Recapitulating Physical Changes in the Extracellular Matrix with Dynamic Hydrogels ......................................................................276

A. Rosales, S. Vega, F. Delrio, J. Burdick, K. Anseth

Fabrication of a Vascularized Tumor Microenvironment for Immunotherapy .....................................................................................277M Dey, E Karhan, C Tastan, D Unutmaz, I Ozbolat

A MMP7-Sensitive Photoclickable Biomimetic Hydrogel for MSC Encapsulation and Engineering Human Cartilage ..........................................................................................................................................................................................................278

E Aisenbrey, S Bryant

Dynamics of Autocrine And Paracrine Domains In Hematopoietic Stem Cell Culture .........................................................................279A. Gilchrist, B. Mahadik, S. Lee, Y. Hu, B. Harley

Measuring Three-Dimensional Shape of Bone Marrow Stromal Cells Cultured in Tissue Engineering Scaffolds ............................280C. Simon, M. Simon, D. Juba, P. Pine, S. Sarkar, D. Chen, P. Baker, S. Bodhak, A. Cardone, M. Brady, P. Bajcsy, B. Pazmino, J. Douglas, W. Keyrouz, C. Lee, S. Florczyk

Riboflavin as a Visible Light Photoinitiator for Dynamic Stiffening Of Cell-Laden Hydrogels ...........................................................281H Nguyen, H Liu, C Lin

Oxygenating Microparticles For Localized Oxygenation To 3D Tissue Environments .........................................................................283P Patil, N Leipzig

Anticancer Efficacy of Tannic Acid is Dependent on the Stiffness of the Underlying Matrix...............................................................284C. Bridgeman, T. Nguyen, V. Kishore

THERAPEUTIC STRATEGIES FOR THE TREATMENT OF INFECTIOUS DISEASES Multifunctional Polymeric Wound Dressing Materials: Combating Drug-Resistance ..........................................................................285

J. Lundin, C. McGann, L. Estrella, E. Cosgriff-Hernandez, J. Wynne

Lipid-Coated Mesoporous Silica Nanoparticles for Antiviral Delivery to Inhibit Encephalitic Alphavirus Infection.......................286T. Rinker, A. Labauve, A. Noureddine, C. Brinker, D. Sasaki, O. Negrete

Combating Fungal Infections Using Responsive Hydrogels for Drug Delivery ......................................................................................287N. Vera-Gonzalez, A. Shukla

Activity and Toxicity of Antibacterial Polyurethanes: A Delicate Balancing Act of Polymer Structural Features............................288A. Joy, S. Mankoci, X. Wang, X. Liu, H. Barton

Preventing S. aureus Biofilm Formation on Titanium Surfaces by the Release of Anti-microbial β peptides from Polyelectrolyte Multilayer Films ...................................................................................................................................................................289

A Rodríguez López, M Lee, D Lynn, S Palecek

Toward Creation of Poly(Methyl Methacrylate) Bone Cement Which Can Be Refilled with Antibiotics After Implantation....................................................................................................................................................................................................291

E. Cyphert, S. Hurley, C. Lu, G. Learn, H. Von Recum

Anti-Biofilm Efficacy of Nitric Oxide-Releasing Alginates against Respiratory Pathogens..................................................................292M Ahonen, M Schoenfisch

On-Demand Pressure-Driven Molecular Release for Active Anti-oxidization ........................................................................................293Y. Seo, J. Leong, J. Teo, J. Mitchell, M. Gillette, B. Han, J. Lee, H. Kong

CONCURRENT SESSION 6 3D BIOPRINTING FOR MEDICAL APPLICATIONS 3D Extrusion Bioprinting of Single- And Double-Network Hydrogels Containing Dynamic Covalent Crosslinks............................294

L Wang, C Highley, Y Yeh, J Galarraga, S Uman, J Burdick

3D Bioprinting Multi-Material Tissue Constructs that Modulate Cell-Driven Compaction.................................................................295T. Hinton, A. Feinberg, A. Lee, A. Hudson

3D Co-print of Epoxy Resin with Cell-laden Bioink for Custom Shaped Nipple-Areola Skin Grafts..................................................296S. Van Belleghem, Z. Mote, J. Fisher, P. Kim

Development of a Universal Bioink Platform Technology for Cross-Platform Compatibility Across Bioprinter Hardware and Support of Multiple Tissue Construct Types ....................................................................................................................297

R Huntwork, A Mazzocchi, H Sivakumar, C Clark, J Aleman, M Devarasetty, A Skardal

Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery ........................................................298H Wang, P Agarwal, X He

Cleft Alveolus Reconstruction Using a Three-dimensional Printed Bioresorbable Scaffold with Human Bone Marrow Cells...................................................................................................................................................................................................299

J Shim, G Ahn, J Lee, W Yun, U Lee

BIOMATERIALS AND SCAFFOLDS FOR ENGINEERING VASCULAR GRAFTS AND BLOOD VESSELS Enhanced Hemocompatibility of Ta-implanted ePTFE Vascular Grafts ................................................................................................300

C Park, E Song, H Lee, M Lee, H Kim

Spatially Patterned Atheroprotective Vascular Grafts for Enhanced Patency .......................................................................................301K Nakayama, M Kawamura, H Wang, J Woo, N Huang

Resorbable Vascular Grafts Show Early Smooth Muscle Formation in a Porcine Dialysis Access Model .........................................302C Stowell, D Celdran-Bonafonte, A Jarrouj, J Janda, Y Wang, P Roy-Chaudhury

An Elastomeric Scaffold Functionalized with SDF- 1α/CXCL12 Via Covalently Linked Syndecan-4 ................................................303H Warner, W Wagner

Multicellular Vascularized Engineered Tissues through User-Programmable Biomaterial Photodegradation .................................304C Arakawa, B Badeau, C Deforest, Y Zheng

Matrix Anisotropy in Cardiac Differentiation and Cell Sheeting.............................................................................................................305J Zoldan, A Allen, L Suggs

The Therapeutic Effect of Fetuin-A on the Calcified State of Smooth Muscle Cells ..............................................................................306J. Mosier, R. Hybart, A. Kay, J. Stewart, C. Simpson

Chitosan-TAM Ccomplex for Long-term Monitoring of Tissue Oxygen Content..................................................................................307C Li, Z Huang, N Gao, H Niu, J Guan

LOCAL DRUG, PROTEIN, AND GENE DELIVERY FROM IMPLANT SURFACES AND COATINGS Fluorescent Tagging of Interleukin-4 for Visualizing In-Vivo Release from Coated Polypropylene Mesh.........................................308

A Nolfi, D Hachim, A Iftikhar, B Brown

In Vitro and In Vivo mRNA Delivery Via Poly (2-Hydroxyethyl Methacrylate) Porous Scaffolds......................................................309R. Chen, H. Zhang, J. Bryers

Nitric Oxide Releasing Nanomatrix to Enhance Dialysis Fistula Maturation.........................................................................................310P Hwang, G Alexander, M Somarathna, R Milican, B Brott, J Pollock, T Lee, H Jun

Characterization of Carbon Monoxide Releasing Poly(diol-citrate) Polymer for Vascular Applications ...........................................311D Lichlyter, A Webb

Degradable Devices for Localized Delivery of Immunosuppressants to Prevent Transplant Rejection ..............................................312J. Molde, K. Dube, C. Iovine, A. Merolli, O. Ortiz, J. Steele, A. Lellouch, Z. Yang Ng, I. Schol, C. Cetrulo, J. Kohn

Controlled Delivery of Local Anesthetics from Novel Biocompatible Wound Dressings.......................................................................313P Alvarez-Urena, S Bhattacharyya, F Li, P Ducheyne

Bioactive Release of Doxycycline from Extracellular Matrix Protein Based Composites......................................................................314Q. Nguyen, A. Benton, M. Marquart, A. Janorkar

Applying Multi-detector GPC/SEC to Complex Characterization of Drug Delivery Polymers ...........................................................315M. Pothecary, C. Schindler, G. Zhang, H. Shen

ENGINEERED BIOMATERIALS FOR NEURAL APPLICATIONS Injectable and Spatially Patterned Particle Hydrogels for Tissue Repair ...............................................................................................316

E Sideris, N Darling, T Segura

pH Responsive Self-Assembling Pentapeptide Hydrogels With Tunable Properties For Neural Tissue Engineering .......................317J Tang, K Lampe

Adult Neural Stem Cell Differentiation In IFNγ Immobilized Chitosan Hydrogel Conduits ...............................................................318H. Baumann, L. Shriver, N. Leipzig, T. Ham

Nanofibrous Scaffold Mediated Gene Knockdown for Neuronal Differentiation of Human Neural Stem Cells ................................319W Chooi, W Ong, A Murray, D Nizetic, S Chew

Hyaluronic Acid-Astrocyte Extracellular Matrix Hydrogels Improve Histological Outcomes following Spinal Cord Injury and Support V2a Interneuron Transplantation .............................................................................................................................320

R. Thompson, J. Pardieck, L. Smith, M. Shoichet, S. Sakiyama-Elbert

The Effects of A Nanofiber-hydrogel Composite on Neuroprotection after Spinal Cord Injury..........................................................321X. Li, J. Yan, C. Zhang, M. Seu, Y. Nitobe, K. Yamane, A. Haggerty, I. Lasuncion, M. Marlow, M. Oudega, H. Mao

ADVANCES IN BIOACTIVE CALCIUM PHOSPHATE CERAMICS AND BIOGLASSES Physical and Histological Comparison of HAp, CO3Ap, and β-TCP Artificial Bone Substitutes .........................................................322

K Ishikawa, A Tsuchiya, K Hayashi, Y Miyamoto, K Tsuru

In Vivo Study of Stable Alpha-TCP Scaffolds Fabricated by Modified Binder Jetting .........................................................................323S. Oyama, M. Watanabe, Y. Tsujimura, K. Yamazawa, H. Yokota

Maturational Changes of Octacalcium Phosphate And Osteoblastic Differentiation ............................................................................324O. Suzuki, T. Anada, Y. Sai, Y. Shiwaku, K. Tsuchiya, T. Takahashi

Antimicrobial Effectiveness of Prosidyan FIBERGRAFT® Bone Graft Substitutes ..............................................................................325R. Batish, S. Bondre, C. Bagga

Porous Calcium Phosphate-Collagen Composite Microspheres for Bone Regeneration .......................................................................326Y Seong, S Jeong, J Kim, H Kim

Evaluation of the Nano-Crystalline Hydroxyapatite Forming ability of Novel Bioactive Glass Micro Fiber - Collagen Matrix ..............................................................................................................................................................................................327

C Bagga, S Bondre

The Morphology and Conversion of Bone Cement and Borate Bioactive Glass Composites into Magnesium-Substituted Hydroxyapatite...........................................................................................................................................................................328

K. Cole, G. Funk, T. McIff

In situ Synthesized Calcium Phosphate/Silk Fibroin Composites for Bone Repair Applications .........................................................329M. Nazeer, E. Yilgör, I. Yilgör

HARNESSING MATRIX BIOLOGY TO CONTROL CELL FATE: A GUEST SYMPOSIUM SPONSORED BY THE AMERICAN SOCIETY FOR MATRIX BIOLOGY Inflammation-Mediated Provisional Matrix Citrullination Leads to Altered Fibroblast Interactions ................................................330

V Stefanelli, D Chambers, V Yeh, K Pesson, S Choudhury, M Torres, T Barker

Breast Cancer Mechanical Background Controls Motility and Metastasis.............................................................................................331A Schwartz, C Hall, S Duquette, S Peyton

Boronate-Based Hydrogels with Fast Relaxation Dynamics for 3D Cell Culture...................................................................................332S. Tang, H. Ma, P. Lin, K. Anseth

Synthetic Hydrogels for Human Intestinal Organoid Generation and Colonic Wound Repair ...........................................................333R. Cruz-Acuña, M. Quirós, A. Farkas, P. Dedhia, S. Huang, D. Siuda, V. García-Hernández, A. Miller, J. Spence, A. Nusrat, A. García

Human Cardiomyocyte Ontogenic Responses to Tissue- and Cell-derived Cardiac Extracellular Matrices......................................334A Silva, A Kauss, J Perez-Bermejo, D Swaney, D Joy, T Hookway, D Nascimento, P Pinto-Do-O, T McDevitt

Force Propagation Through Fibrous Matrices Modulates Endothelial Cell Network Formation........................................................335C. Davidson, W. Wang, V. Chu, B. Baker

GLYCOMATERIALS Development of a Glycocalyx Mimetic .........................................................................................................................................................336

A Panitch, J Wodicka, V Morikis, A Chambers, G Sangha, C Goergen, S Simon

Intra-Articular TSG-6 Delivery from Heparin-based Microparticles Reduces Cartilage Damage in a Rat Model of Osteoarthritis ..................................................................................................................................................................................................337

L. Tellier, E. Treviño, A. Brimeyer, D. Reese, N. Willett, R. Guldberg, J. Temenoff

Hyaluronic Acid Modification Alters CD44 Binding in Soluble and Hydrogel Forms ..........................................................................338M. Kwon, C. Wang, L. Han, R. Mauck, J. Burdick

Viscoelastic Hyaluronic Acid (HA) Hydrogels to Study Hepatic Stellate Cell Mechanobiology ...........................................................339E. Hui, G. Guan, S. Caliari

Glycosylation-Dependent Hierarchical Assembly of Low-Fouling Supramolecular Hydrogels ...........................................................340A Restuccia, G Hudalla

Glyco-adjuvant Vaccines for Enhanced Cellular and Humoral Immunity .............................................................................................341D Wilson, M Raczy, M Swartz, J Hubbell

CONCURRENT SESSION 7 ENZYME-ASSISTED BIOMATERIAL FABRICATION AND MODIFICATION FOR BIOLOGICAL APPLICATIONS Synthetic B-cells for Fusion-Mediated Dynamic Insulin Secretion ..........................................................................................................342

G Chen, J Wang, Z Gu

Reversibly Stiffened Hydrogels Via Enzyme-Mediated Peptide Ligation ...............................................................................................343C. Lin, M. Arkenberg, D. Moore

Enzyme-Mediated Chemical Modifications of Silk Fibroin Towards Advanced Biofunctional Silk Hydrogels .................................344M. McGill, D. Kaplan

Sustained Release of Antimicrobial Drugs from Graphene Oxide Immobilized Titanium Surfaces for the Enhanced Anti-bacterial Activity .................................................................................................................................................................345

D. Tran, T. Hoang Thi, T. Le, K. Park

Engineering Highly Stable Enzyme-Polymer Conjugates: Molecular Dynamics Simulation Study ....................................................346S. Tu, C. Choudhury, S. Collins, N. Yadavalli, N. Borodinov, I. Luzinov, S. Minko, O. Kuksenok

Design of Enzymatically Triggered Shape Memory Polymers ..................................................................................................................347J Henderson, P Mather, S Buffington, C Lee

Hypoxia-Inducible Hydrogels via Enzyme-Immobilization ......................................................................................................................348B. Hudson, H. Liu, C. Dawes, C. Lin

Controlled Cell Migration within Cell Selective Hydrogels.......................................................................................................................349E Pashuck, N Joshi, S Fung, K Kim, J Kohn

CARDIOVASCULAR BIOMATERIALS Evaluation of Multi-Axial 3D Printed Bioresorbable Vascular Scaffolds for Peripheral Vascular Interventional Application ......................................................................................................................................................................................................350

H. Zhao, J. Zhang, Q. Liu, Z. Chen, X. Weng, N. Yu, B. Liu

In Vivo Sheep and Rabbit Models for Evaluating Low-fouling Zwitterionic Polymer Coatings in Artificial Lungs .........................351R. Ukita, K. Wu, X. Lin, N. Carleton, N. Naito, A. Lai, C. Do-Nguyen, C. Demarest, S. Jiang, K. Cook

Elucidating the Role of Graft Compliance Mismatch in Intimal Hyperplasia using an Ex Vivo Organ Culture Model ...............................................................................................................................................................................................................352

A. Post, P. Diaz-Rodriguez, S. Paulsen, J. Miller, M. Hahn, E. Cosgriff-Hernandez

Syndecan-1 in Mechanosensing of Nanotopological Cues..........................................................................................................................353V Le, J Lee, S Chaterji, A Spencer, Y Liu, P Kim, H Yeh, D Kim, A Baker

Transmembrane Stem Cell Factor Protein Therapy for Peripheral Vascular Disease using Novel Lipid Carriers ..........................354E. Takematsu, J. Auster, A. Singh, P. Chen, S. Canga, M. Sherman, A. Degroot, A. Dunn, A. Baker

Carbon Monoxide Releasing Molecules-Loaded Electrospun Scaffolds Impact Vascular Endothelial Cell Function.......................355K. Washington, M. Sameti, N. Abeyrathna, C. Martino, Y. Liao, C. Bashur

Direct Encapsulation of hiPSCs in Gelatin Methacryloyl to Produce Human Engineered Cardiac Tissues.......................................356M. Ellis, P. Kerscher, J. Kaczmarek, S. Head, W. Seeto, J. Kim, S. Bhattacharya, V. Suppiramaniam, E. Lipke

Self-Assembled Hydrogels for Local, Sustained Delivery of a Small Molecule MMP Inhibitor after Myocardial Infarction .........................................................................................................................................................................................................357

J Mealy, S Barlow, H Doviak, J Jacobs, W Torres, J Howard, F Spinale, J Burdick

SUPRAMOLECULAR NANOMATERIALS FOR DRUG DELIVERY, IMAGING, AND IMMUNOENGINEERING 2 Supramolecular Tools for Modulating the Morphology of Self-Assembled Helical Peptide Nanofibers .............................................358

C Fries, J Collier, Y Wu, M Wolf

Dynamic Light Scattering of Bottlebrush Polymers ...................................................................................................................................359A Kriete, K Prudnikova, M Marcolongo

Optimizing Mannose Conjugation to Polymeric Nanoparticles for Targeted Delivery to Tumor Associated Macrophages in Breast Cancer .....................................................................................................................................................................360

E. Glass, S. Masjedi, S. Dudzinski, T. Giorgio

Multiarm Avidin Nanoconstruct as a Cationic Carrier for Intra-cartilage Drug Delivery ...................................................................361A Vedadghavami, S Mehta, A Bajpayee, S Bhakta

Biomimetic Peptide Display from a Polymeric Nanoparticle Surface for Dual Functionality to Target and Treat Cancer ..............................................................................................................................................................................................................362

J. Green, J. Kim, E. Bressler, R. Shmueli, A. Mirando, H. Bazzazi, E. Lee, A. Popel, N. Pandey

Subconjunctival Delivery of Nanoparticles for Safe and Efficient Treatment of Corneal Allograft Rejection...................................363Q. Xu, M. Chen, Q. Pan, W. Stark, J. Hanes

Aggregation Behavior of Elastin-Like Polypeptide Copolymers ..............................................................................................................364A. Engel, J. Cobb, A. Janorkar

Immunomodulatory Vasoactive Intestinal Peptide Amphiphile Micelles................................................................................................365R. Zhang, C. Leeper, X. Wang, G. Seim, B. Ulery

PROTEIN AND CELLS INTERFACES Contact Activation by The Intrinsic Pathway of Blood Plasma Coagulation..........................................................................................366

L. Xu, Y. Yan, C. Siedlecki

A Visual Study of the SynB1-Elastin Like Polypeptide Agglomeration ...................................................................................................367A. Janorkar, J. Correia, V. Zai-Rose, J. Cobb

Toll-like Receptor 2-mediated Inflammatory Response to Polymeric Biomaterials ..............................................................................368L McKiel, L Fitzpatrick

Elucidating Valve Interstitial Cell-ECM Biomechanical Interactions Using Poly(ethylene glycol) Hydrogels...................................369A Khang, A Gonzalez Rodriguez, M Schroeder, K Anseth, M Sacks

Covalent Tethering of Signaling Proteins to Hydrogels Through a Reversible Thiol-Ene Bioconjugation.........................................370J Grim, B Aguado, T Brown, K Anseth

Engineered Microtopographies to Guide and Control Cellular Response of Fibroblasts and Schwann Cells: Sharklet® Versus Channels............................................................................................................................................................................371

S Mobini, C Kuliasha, N Bohmann, J Judy, K Otto, C Schmidt, A Brennan

Influence of Chitosan-Alginate Scaffold Stiffness on Bone Marrow Stromal Cell Differentiation .......................................................372I Arias, M Le, B Ding, K Xu, Z Wang, S Florczyk

Cellular Interactions and Bone Affinity of Poly(Ethylene Sodium Phosphate) ......................................................................................373Y Iwasaki, A. Yokota, A. Otaka, M. Neo

BIOMATERIAL-MEDIATED CONTROL OF IMMUNITY FOR REGNERATIVE MEDICINE Localizing Pro-Regenerative Inflammation Via Nanoscale Fiber Scaffolds Improves Volumetric Muscle Defect Healing .............................................................................................................................................................................................................374

E Botchwey, C San Emeterio, M Ogle

Sequential Cytokine Delivery for Modification of the Host Immune Response to Implants in the Context of Aging ........................375D Hachim, B Brown

Modulation of Leukocyte Infiltration into Biomaterial Scaffolds Engineered to Release Anti-Inflammatory Small Molecules .........................................................................................................................................................................................................376

K Murphy, M Gower

Novel Microparticle-based Strategy to Maintain Macrophage Phenotype at Sites of Injury................................................................377K Wofford, B Singh, K Cullen, K Spiller

A Novel “Anti-Vaccine” for the Treatment of Collagen-Induced Arthritis.............................................................................................378R Allen, S Chizari, J Lewis

Allogeneic Ovarian Tissue Encapsulated in Poly(Ethylene Glycol)-Vinyl Sulfone and TheraCyte Immunoisolates and Restores Endocrine Function in Adult Ovariectomized Mice ...........................................................................................................379

A David, J Day, A Lefferts, M Cascalho, A Shikanov

Anti-inflammatory Nanomolecules to Modulate Inflammation in a Mouse Model of Crohn’s Disease...............................................380M. Karver, A. Sharma, N. Fuller, M. Bury

Understanding the Role of Macrophages in the FBR-mediated Reduction of in vitro Osteogenic Capabilities of MC3T3-E1 Cells Encapsulated in a Biomimetic Poly(ethylene glycol) Hydrogel ...................................................................................381

L. Saleh, M. Carles-Carner, A. Frederickson, C. Vanderheyden, S. Bryant

CONCURRENT SESSION 8 SURFACE CHARACTERIZATION AND MODIFICATION Covalent Grafting of Antifouling Polyzwitterion with Antimicrobial Nitric Oxide Releasing Polymers to Enhance Infection-Resistant Properties.......................................................................................................................................................................382

P. Singha, Q. Liu, J. Locklin, H. Handa

Long Term Nitric Oxide Releasing Polydimethylsiloxane for Implantable Medical Device Applications ..........................................383S. Hopkins, J. Pant, M. Goudie, H. Handa

Surface Modification of Alkyne-Functionalized Poly(lactic-co-glycolic acid) Particles for Breast Cancer Stem Cell Targeting .........................................................................................................................................................................................................384

K. McEnnis, S. Rahmani, S. McDermott, S. Roghani Esfahani, J. Lahann

Surface Characterization of Ionic Liquid Coatings on Biomaterial Substrates......................................................................................385D Siddiqui, M Ammanamanchi, P Sandhu, I Gindri, D Rodrigues

Evaluation of S-nitroso-N-acetylpenicillamine (SNAP)- Based Polymer from a Translational Perspective .......................................386E. Brisbois, M. Goudie, J. Pant, H. Handa

Photocatalytic Activity and Osteoblast Viability of UV-Treated Titanium Oxides ................................................................................387H. Johnson, P. Pal, A. Janorkar, R. Williamson, M. Roach

Surface Modification of Polypropylene Surgical Meshes for Improving Adhesion with Poloxamine Hydrogel Adhesive...........................................................................................................................................................................................................388

X. Lu, A. Khanna, I. Luzinov, J. Nagatomi, M. Harman

Nanostructured Amorphous Magnesium Phosphate / Poly (lactic acid) Composite Coating for Enhanced Corrosion Resistance and Bioactivity of Biodegradable AZ31 Magnesium Alloy ..................................................................................389

Y Ren, E Babaie, S Bhaduri

NANO MATERIALS Multiple Functions of Cancer Targeting, Imaging and Photothermal Therapy by Au-based Theranostics Released from Advanced Tissue Engineering Scaffolds .............................................................................................................................................390

L. Guo, M. Wang

NIR-Induced Spatiotemporally Controlled Gene Silencing by Upconversion Nanoparticle-based siRNA Nanocarrier .....................................................................................................................................................................................................391

G. Chen, B. Ma, R. Xie, Y. Wang, K. Dou, S. Gong

Whole-Transcriptome Analysis of Human Stem Cells Treated with Two-Dimensional Nanosilicates ................................................392J Carrow, L Cross, R Reese, R Kaunas, I Singh, A Gaharwar

Manganese Dioxide Nanoparticles Protect Cytokine-Challenged Cartilage from Oxidative Stress.....................................................393S Kumar, I Adjei, B Sharma

Spherical Nucleic Acid Architecture Can Improve the Efficacy of Polycation-Mediated siRNA Delivery .........................................394J. Melamed, N. Kreuzberger, E. Day

Cell-Cell Anchor Molecules for 3D-Cell Micropatterning on Cell/Tissue Surfaces................................................................................395M. Matsusaki, K. Yanagisawa

Nanoparticle-based Molecular Beacon for Small RNA Detection by Gold Nanoparticles and Upconversion Nanoparticles ..................................................................................................................................................................................................396

Y Sun, C Mao

Site-Selective RNA Splicing Nanozyme: DNAzyme and RtcB Conjugates on a Gold Nanoparticle ....................................................397J. Petree, K. Yehl, K. Galior, R. Glazier, B. Deal, K. Salaita

SUPRAMOLECULAR DESIGN OF NETWORK BIOMATERIALS Adaptable Biomaterials for Expansion and Transplantation of Stem Cells ............................................................................................398

C. Madl, B. Lesavage, R. Dewi, S. Heilshorn

Tailoring Supramolecular Guest-Host Hydrogel Properties with Covalent Double Networks.............................................................399C. Loebel, A. Ayoub, J. Galarraga, O. Kossover, H. Simaan-Yameen, D. Seliktar, J. Burdick

Supramolecular Vesicles Transitioned from Coacervates Composed of Recombinant Fusion Protein Complexes ...........................400Y Jang, M Hsieh, S Guo, M Grover, J Champion

Genetically Encoded Lipid-Polypeptide Hybrid Biomaterials that Exhibit Temperature Triggered Hierarchical Self-Assembly ..................................................................................................................................................................................................401

D Mozhdehi, K Luginbuhl, A Chilkoti

Photolymerized Dynamic Hydrogels with Tunable Viscoelastic Properties Through Thioester Exchange ........................................402B. Carberry, T. Brown, B. Worrell, O. Dudaryeva, M. McBride, C. Bowman, K. Anseth

A Thermo-Responsive Citrate-based Macromolecule for Transarterial Embolotherapy .....................................................................403S. Ramachandra, J. Yang, S. Lee, G. Ameer, Y. Zhu, P. Pytel, A. Chang

Supramolecular Peptide and Protein Matrices for Prostate Cancer Organoid Culture ........................................................................404K Hainline, F Gu, D Vander Griend, J Collier

TISSUE ENGINEERING Improved hMSC Seeding and Surface Modification of 3D Printed Bone Grafts ...................................................................................405

P. Dhavalikar, M. Whitely, S. Cereceres, K. Kapilov-Buchman, T. Wilems, M. Silverstein, E. Cosgriff-Hernandez

An Injectable and Settable Poly(thioketal urethane) Autograft Extender for Grafting Open Fractures ............................................406M McGough, S Shiels, L Boller, J Wenke, S Guelcher

Linking the Cellular Microenvironment to Macroscopic Properties of Cell-Laden Photopolymerized Hydrogels ...........................407S Chu, K Calahan, P Bhusal, S Lalitha Sridhar, M Maples, F Vernerey, S Bryant

Controlling Cell Cluster Parameter for Improved Cartilage Tissue Engineering in Photoclickable PEG Hydrogels .......................408M. Schneider, S. Lalitha Sridhar, F. Vernerey, S. Bryant

Production of Cardiac Tissue Spheroids using a Novel Microfluidic System .........................................................................................409F. Finklea, Y. Tian, P. Kerscher, W. Seeto, E. Lipke

Two-dimensional Nanosilicates for Therapeutic Protein Delivery ...........................................................................................................410L. Cross, J. Carrow, M. Muscarello, A. Gaharwar

Biomimetic Elastin-Containing Bi-layered Scaffold for Vascular Tissue Engineering ..........................................................................411T. Nguyen, M. Shojaee, C. Bashur, V. Kishore

Theranostics-embedded and Growth Factor-incorporated Multifunctional Scaffolds for Post-surgery Cancer Patients.............................................................................................................................................................................................................412

L. Guo, M. Wang

MATERIALS FOR CARDIOVASCULAR DEVICES AND BLOOD COMPATIBILITY Bacteria and Blood Coagulation Responses to Textured/Nitric Oxide Releasing Biomaterial Surfaces..............................................413

L. Xu, D. Sun, T. Wood, M. Meyerhoff, C. Siedlecki

Thrombogenicity Evaluation of Medical Device Materials with an In Vitro Flow Loop System Under Vary-ing Flow Conditions ..............................................................................................................................................................................................414

M. Jamiolkowski, M. Golding, Z. Goddard, R. Malinauskas, Q. Lu

In Vitro Accelerated Fatigue Study of Chimney Stent-grafts Deployed in a Patient’s Aortic Aneurysm Phantom...........................415R Zhang, S Crawford, I Robertson, S Marks, M King

Design of a Shape Memory Polymer, Poly-Glycerol Dodecanoate, And Small Intestinal Submucosa (Cormatrix®) Composite Material For Atrial Septal Defect Occlusion In A Porcine Model ........................................................................................416

H Ramaraju, L Solorio, M Bocks, S Hollister

Heparin-Functionalized Polymer Graft Surface Eluting MK2 Inhibitory Peptide For Vascular Graft Applications .......................417Y Lee, P Le Thi, G Seon, C Brophy, Y Kim, J Park, K Park, J Cheung-Flynn, H Sung

Surface Fluorination of Polylactides for Enhanced Hemocompatibility..................................................................................................418R Khalifehzadeh, B D. Ratner

Nanomatrix Coated Stent Enhances Endothelialization but Reduces Platelet, Smooth Muscle Cell, and Monocyte Adhesion under Physiologic Conditions.......................................................................................................................................................419

G. Alexander, P. Hwang, J. Chen, J. Kim, B. Brott, Y. Yoon, H. Jun

In-vitro Oxidative Stability of High Strength Siloxane Poly(urethane-urea) Elastomers Developed for Heart Valve Application ......................................................................................................................................................................................................420

L Dandeniyage, P Gunatillake, R Adhikari, M Bown, R Shanks, B Adhikari

OPHTHALMIC BIOMATERIALS SIG Engineering a Regeneration Permissive Substrate as Therapeutics for Retinal Degeneration.............................................................421

J Kundu, P Baranov, S Kim, A Yandulskaya, J Monaghan, R Linhardt, M Young, R Carrier

Posterior Ocular Drug Delivery for Treatment of Wet- AMD using Injectable, Degradable POEGMA Hydrogels .........................422E Paron, B Muirhead, H Sheardown, T Hoare

ATRP Surface Modification of Contact Lenses for Improving Lens Comfort by Interacting of PolyAPBA and Polysaccharide Wetting Agents.....................................................................................................................................................................423

H Sheardown, L Liu

Preliminary, In Vitro Optimization of a Controlled Release Cysteamine Eye Drop ..............................................................................424J Jimenez, M Washington, M Fedorchak, K Nischal

Properties of IOLs after Gamma Radiation................................................................................................................................................425C. Hu, F. Chen, M. Lowery

Carboxymethylated Hyaluronic Acid-based Delivery of Small Molecule to Ocular Surface ................................................................426H. Lee, S. Luo, B. Wirostko, B. Mann

Polyethylene Glycol Methacrylate-Based Polymeric Micelles for Ocular Drug Delivery ......................................................................427H Sheardown, J Leung

Delivery of Stem Cells using Biomimetic Materials Designed for Ocular Surface Repair ....................................................................428B Janet, B Corliss, L Costella, R Redmond, A Eiseman, C Tison, K. Mangham

ORTHOPAEDIC BIOMATERIALS Decorin-Supplemented Collagen Scaffolds for Co-Delivery of Microvascular Fragments and Bone Morphogenetic Protein 2...........................................................................................................................................................................................................429

M. Ruehle, L. Krishnan, N. Willett, R. Guldberg

Bisphosphonates Inhibit Bone Marrow Recovery Following Injury ........................................................................................................430D Cohen, E Lotz, P Daire, I Nalic, V Patel, B Boyan, Z Schwartz

Mechanisms for Mechanically Assisted Electrochemical Degradation of Alumina-TiC Composite ....................................................431H Maharaja, G Zhang

Large-scale Fabrication of Highly Aligned and Mechanically Robust Nanofiber Scaffolds as Orthopaedic Biomaterials ....................................................................................................................................................................................................432

S. Zhang, B. Ding, B. Li

Does Macrophage Polarization Modulate Cell Induced Corrosion in CoCrMo alloy? ..........................................................................433S. Salunkhe, D. Bijukumar, G. Zheng, D. Hall, M. Mathew, R. Pourzal

Multi-Laminate, Angle-Ply Annulus Fibrosus Repair Implant Injected with Glycosaminoglycan Gel Demonstrates Increased Biaxial Impact Resistance and Restores Spinal Kinematics ....................................................................................................434

R. Borem, J. Walters, A. Madeline, R. Vela, S. Gill, J. Mercuri

ENGINEERED MICROENVIRONMENTS TO MODEL CANCER Tunable Biomaterials to Identify Mechanisms of ECM-Mediated Drug Resistance in Breast Cancer ...............................................435

A Schwartz, L Barney, L Jansen, T Nguyen, C Hall, A Meyer, S Peyton

3D in vitro Recapitulation of the Native Breast Tumor Microenvironment in a Vascularized Tumor Mimetic Microfluidic Chip ...........................................................................................................................................................................................436

B Anbiah, I Hassani, N Habbit, S Jasper, M Egghert, B Prabhakarpandian, R Arnold, E Lipke

Desmoplasia-mimetic Gels with Modular and Temporal Properties for Modeling Pancreatic Cancer Progression .........................437H. Liu, C. Lin

Mineralized Matrices to Model Malignant Microcalcification-Induced Breast Tumor Progression ...................................................438M Singh, A Patel, S Rangnathan, S Sant

Designer Tumor Microenvironments To Study B Cell Lymphoid Tumors and MALT1 Signaling .....................................................439S. Shah, E. Abeles, K. Lee, L. Fontan, A. Melnick, A. Singh

Perivascular Signals Alter Global Genomic Profile of Glioblastoma and Response to Temozolomide in an Engineered Tumor Microenvironment ........................................................................................................................................................440

M. Ngo, B. Harley

Glioblastoma Stem Cell Phenotype Regulation Via CD44 on Tumor Microenvironment Mimicking Hyaluronic Acid Hydrogel .................................................................................................................................................................................................441

S. Park, A. Narkhede, S. Rao, Y. Kim

Development of a 3D Scaffold for Modelling Aggressive Lymphoma ......................................................................................................442L. Bahlmann, A. Baker, R. Laister, M. Shoichet

POSTER PRESENTATIONS *BTI* ASSAYS TO EVALUATE CELL AND TISSUE INTERACTIONS WITH BIOMATERIALS Protein Nanoencapsulation-A Novel Platform to Overcome Challenges in the Preparation of Protein-Depot for Various Therapeutic Applications ................................................................................................................................................................443

P. Polley, V. Remya, J. Giri

Myocardial Extracellular Matrix Embedded with Synthetic Cardiac Stem Cells for Cardiac Regeneration.....................................444K. Huang, T. Su, J. Tang, E. Rrona, L. Qiao, M. Hensley, D. Freytes, K. Cheng

PART 2

Hydroxyapatite (HA) Patterning for Alignment of Endothelial Cells for Vascular Graft Application ...............................................446

I Kang, M Lee, H Lee, C Park, H Kim

Biologically Active Gelatin-based Scaffolds for Bone Tissue Engineering in Rat Calvarial and Rat Hip Defect Models ..............................................................................................................................................................................................................447

M Echave, P Sanchez, E Anitua, J Pedraz, G Orive

*BTI* BIOCOMPATIBILITY EVALUATIONS – RISK, TESTS AND NEW TECHNOLOGY Determining Worst-Case Ni Release in Benchtop Studies of Nitinol .......................................................................................................448

E Sussman, S Sivan, V Chandrasekar, H Shin, J Weaver, M Di Prima, D Saylor

*BTI* FROM CONCEPTION TO CLINICAL TRIAL: EXAMPLES OF TECHNOLOGY DEVELOPMENT A Biomimetic Hydrogel Coating Platform to Improve Contact Lens Comfort ......................................................................................449

K Havenstrite, K. Mabry, M. Walters

X-Ray Diffraction and Rietveld Quantitative Analysis of Solution Deposited Hydroxyapatite Coatings on Orthopedic Implants ......................................................................................................................................................................................450

J Langhorn, R Kasinath

*BTI* TRANSLATING BIOMATERIALS FOR REGENERATIVE ENGINEERING Bioresorbable Composites: A Microscopic View of Structure-Property-Processing Effect(*BTI*) ....................................................451

B Prabhu, M Dadsetan, J Santiago, H Liedtke

Development of an Injectable Thermoresponsive Gel Matrix for Comprehensive Ocular Trauma Management ............................452M Washington, J Yu, M Fedorchak

Bacteriophage Encapsulation Reduces Pseudomonas Aeruginosa Colonization of Hydrogel Scaffold ...............................................453J Wroe, C Johnson, A Garcia

Preclinical in vitro and in vivo Assessment of Linear and Branched L-Valine Based Poly(ester urea)s for Soft-tissue Applications ..........................................................................................................................................................................................454

N Dreger, M Wandel, L Robinson, D Luong, C Sondergaard, M Hiles, C Premanandan, M Becker

Micronized Amnion/Chorion Delivery Promotes Mesenchymal Stem Cell Recruitment to the Supraspinatus Muscle After Rotator Cuff Injury ................................................................................................................................................................455

L Anderson, L Tellier, A Fallon, T Koob, J Temenoff

*BTI* TRANSLATIONAL BIOMATERIALS RESEARCH Textile Engineered Small Diameter Vessels for Vascular Tissue Regeneration......................................................................................456

S Lu, T Fukunishi, C Smoot, C Ong, P Gabriele, N Hibino, J Harris

A Clinically Relevant Rabbit Surgical Model of Pelvic Reconstruction to Evaluate the Immune Response to Novel Surgical Materials ..........................................................................................................................................................................................457

A. Iftikhar, A. Nolfi, P. Moalli, B. Brown

Aged Decellularized Muscle Matrix Negatively Impacts Myogenic Differentiation and Fusion...........................................................458L. Olson, M. McClure, M. Rashid, B. Boyan, Z. Schwartz

Engineering a Highly Elastic and Adhesive Naturally Derived Sealant...................................................................................................459N. Annabi, Y. Zhang, A. Assmann, E. Shirzaei Sani, A. Lassaletta, G. Cheng, B. Dehghani, A. Vegh, G. Ulises Ruiz-Esparza, X. Wang, S. Gangadharan, A. Weiss, A. Khademhosseini

3D AND MICROFLUIDIC TECHNOLOGIES FOR IMMUNOENGINEERING Functionalized Microcarriers for Enhanced CAR T Cell Manufacturing ..............................................................................................460

N. Dwarshuis, H. Wilson, A. Patel, K. Roy

Microfluidic System Integrated Contact Lens for Tear Sampling ...........................................................................................................461O Kim, Y Song, J Kim

3D BIOPRINTING FOR MEDICAL APPLICATIONS Printability Analysis Models .........................................................................................................................................................................462

P Thayer, E Rebholz, H Abushall

The Impact of Cells on 3D Printing in Cell-Laden Hydrogel Resins........................................................................................................463H. Baker, T. Jain, A. Gipsov, A. Joy, J. Fisher, D. Kaplan, I. Isayeva

Patient-Specific 3D Printed Elastomeric Wearable Medical Devices .......................................................................................................464S. Abdollahi, E. Markvicka, C. Majidi, A. Feinberg

Characterization of 3D Printed PEEK Lumbar Interbody Fusion Devices via Fused Filament Fabrication .....................................465C. Basgul, T. Yu, B. Dobson, D. Macdonald, R. Siskey, M. Marcolongo, S. Kurtz

Microchannels Generation Using a Rapid Subtractive 3D Printing System for Tissue Vascularization .............................................466M. Sameti, S. Burtch, R. Allado, R. Olmstead, C. Bashur

Effects of Pore Size in 3D Printed Tissue Scaffolds on Murine Fibroblast Proliferation.......................................................................467N. Chartrain, J. Cartwright, S. Eubanks, W. Surbey, C. Williams, A. Whittington

Bioprinting of 3D Vascular Networks within Cell-Laden Hydrogels .......................................................................................................468S Ji, E Almeida, M Guvendiren

Precise Stacking of 3D-printed Cell-laden Constructs Using a Decellularized Extracellular Matrix-based Bioink...........................469G Ahn, K Min, M Kim, C Kim, M Kim, W Yun, J Shim

Highly Elastic Biodegradable Hydrogel for Cell Printing .........................................................................................................................471C Xu, C Xu, W Lee, G Dai, Y Hong, Y Hong

Bioprinting of Gelatin Hydrogels Reinforced with Cellulose Nanocrystals for Tissue Engineering Applications..............................472S Piluso, W Thielemans, J Patterson

Bioink Development for 3D Bioprinting Aortic Heart Valves...................................................................................................................473A. Nachlas, S. Li, M. Davis

In Situ Bioprinting of Bone Tissue Constructs............................................................................................................................................474K Moncal, K Godzik, O Mrowczynski, E Rizk, S Tucker, A Do, A Salem, G Lewis, I Ozbolat

Novel Three-dimensional Bioprinting Systems Using Printable Bioinks .................................................................................................475G Ahn, K Min, M Kim, C Kim, S Jin, W Yun, J Shim

Immobilization of Fibronectin and Elastin protein Domains in 3D PEG Hydrogels .............................................................................476K Hyland, T Miao, R Agarwal, A Garcia, J Champion

Enhanced Cell Functions on Graphene Oxide Incorporated 3D Printed Polycaprolactone Scaffolds.................................................477N Jayatissa, A Jayasuriya, J Unagolla

3D Printed Gelatin Scaffold for Conjunctival Reconstruction..................................................................................................................478S. Dehghani, M. Rasoulian, S. Heidari, Z. Nozarian, M. Hashemian, M. Zare, G. Latifi, L. Tayebi, H. Ghassemi

Patient-specific 3D Models Providing a 21st Century Approach to Reconstructive Surgery.................................................................479H. Liss, S. Maliha, J. Bekisz, L. Witek, A. Humayun, K. Khouri, S. Raffaelli, P. Coelho, R. Flores

Haptic Assessment of Neurosurgical Model of the Brain and Nerves ......................................................................................................480M. Cavrak, E. Keating, V. Sama, M. Navarro, D. Dean, J. Rodriguez-Devora

Tissue Engineering Test System: Optimization of Bead and Gel Deposition for Layer by Layer Tissue Building with a Biofabricator .......................................................................................................................................................................................481

J Williams, R Ahn, N Robertson, K Burg, T Burg

Assessment of Bioglass Incorporated Collagen Bioinks for 3-D Bioprinting ..........................................................................................482N Kajave, B Bagley, D Bagley, V Kishore

In Vivo Evaluation of a Collagen-Based Bioink for 3D-Bioprinting of a Tissue-Engineered Aortic Heart Valve ..............................483E Maxson, B Heidari, D Morse, C Noble, F Franchi, R Khorramirouz, M Young, A Lerman

3D Printing of PEG Hydrogel Scaffolds Using Novel Low Toxicity Photoinitiator................................................................................484M Frishberg, M Lin, X Zhao, Z Wei

APPROACHES TO ACCELERATE DEVELOPMENT OF NOVEL DENTAL BIOMATERIALS: PREDICTIVE TOOLS TO CHARACTERIZE LONG-TERM DURABILITY, SAFETY AND EFFECTIVENESS Theaflavins, Tea Extract from Camellia Sinensis, Are Rapid and Effective Dentin Collagen Stabilizer ............................................485

H Liu, Y Wang

Biomimetic Design of Graded Ceramic Restorative Materials for Enhanced Performance .................................................................486Y Zhang

Lanthanides-Doped Upconversion and Downconversion Hydroxyapatite Nanoparticles for Biomedical Tracking..........................487X. Li, W. Li

Chitosan-Calcium Phosphate Composite Materials As Injectable Self Setting Regenerative Dental Materials .................................488M Osmond, J Harding, M Krebs

Investigation of Microbiota Composition and Surface Characteristics of Retrieved Implant Healing Abutments............................489S. Jain, S. Wheelis, W. Huo, D. Siddiqui, T. Wilson, P. Valderrama, D. Rodrigues

BIOACTIVE GLASSES AND CERAMICS In Vitro Evaluation of 34.12SiO2 -17.06MgO-7.94 P2O5-40.88 CaO Composition for Orthopedic Applications ................................490

P. Kaur, K. Singh, A. Yadav, R. Kaur

Mineralized Alginate Hydrogels using Marine Carbonates; Synthesis and Tissue Engineering Applications ...................................491P Diaz-Rodriguez, P Garcia-Triñanes, M Echezarreta-López, M Landin

BIOMATERIAL TECHNOLOGIES FOR HEMOSTASIS AND WOUND CARE Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy ................................................................492

Q Hu, W Sun, H Bomba, Z Gu

Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa........................................................................................................................................................................................................493

D Medina, T Webster

Acceleration of Wound Healing and Hemostasis Ability of New Chitosan-Silica Hybrid Dressing Material .....................................494J. Park, S. Jung, E. Song, B. Kim, S. Jung, I. Chung, H. Kim, S. Kim

Effects of Aging on Degradation of Shape Memory Polymer Foams for Aneurysm Treatment...........................................................495S Reine, M Monroe, K Grant, K Balakrishna, M Hasan, D Maitland

Heparin-chitosan Based Nanoparticles for Wound Healing Antibiotic Delivery....................................................................................496S. Fathollahipour, N. Leipzig

Fabrication and Characterization of Cellulose-Sodium Carboxymethyl Cellulose based Hydrogels for Biomedical Applications.....................................................................................................................................................................................................497

T. Bambharoliya, R. Vaid, S. Zia, A. Islam, A. Sabir, T. Jamil, M. King

Effect of Modulating Crosslink Density on Margination and Biodistribution of Platelet-like Particles ..............................................498J. Nicosia, D. Chambers, M. Harp, A. Fernandez-Nieves, W. Lam, A. Brown, T. Barker

Characterization of Biocompatible Hydrogel for Wound Healing Applications ....................................................................................499J. Kerley, J. Nagatomi, T. Konno, K. Fukazawa, K. Ishihara

Structure Related Hemostatic Property of Human Hair Extracted Keratins at Different Temperature ............................................500L. Huang, Y. Wei, K. Wang, Y. Chen

Designing an Antimicrobial Knitted Spacer Fabric with Chitosan for Vacuum Assisted Wound Closure .........................................501D. Zha, P. Nakod, T. He, A. El-Shafei, A. Brown

Development and Evaluation of Novel Smart Dressing Containing a Biosensor to Monitor Infected Wounds..................................502J Lee, T Yeo, Y Ko, O Kwon

Chitosan-based Injectable and Self-healing Hydrogels with High Strength for Hemostasis.................................................................503W Huang, L Chen

Comparing Polyhexanide and Gentamicin Release from Melt-spun Poly-l-lactide, Poly-ε-caprolactone, and Cellulose acetate butyrate Fibers as Potential Wound Healing Scaffolds................................................................................................504

E Gianino, J Gilmore

The Evaluation of the Duck’s Feet Collagen Sponge for Hemostatic Applications ................................................................................505O Lee, Y Seo, C Park

BIOMATERIAL TECHNOLOGIES FOR PRECISION MEDICINE Ultrasound Stimulation Mediates Microgel Deformation to Tune Drug Release Kinetics ....................................................................506

S. Nandi, A. Joshi, M. Muller, A. Brown

Polymer Scaffolds Protect Mice Against Diet Induced Obesity and Glucose Intolerance .....................................................................507M Hendley, P Annamalai, M Gower

Engineering Fibrin Nanoparticles to Enhance Wound Healing................................................................................................................508I Muhamed, E Sproul, F Ligler, A Brown

Biomechanical Evaluation of Injectable Biomaterials for Vocal Fold Augmentation ............................................................................509J Pearson, S Montelongo, T Guda, G Dion

Testing Wicking Fiber Capability: Developing a Microscope System to Observe Cell Movement in a Wicking Fiber .....................510L Estes, Q Jones, R Marti, T Burg, K Burg

Quantitative Prediction of Molecular Properties in a Nanopore Sensor .................................................................................................511S Bearden, T Abramyan, D Gil, J Johnson, D Mai, V Ivanov, V Reukov, G Zhang

Subcutaneous Nanodisc Vaccination with Dualadjuvants for Cancer Immunotherapy........................................................................512X Sun, R Kuai, A Schwendeman, J Moon

Covalent Functionalization of Poly(Glycerol Sebacate) .............................................................................................................................513B Nicholson, J Harris, S Lu, P Gabriele, C Smoot

Surfen, a Small Molecule Glycosaminoglycan Antagonist, Attenuates Glioma Stem Cell Infiltration in a Rodent Model of Glioma .............................................................................................................................................................................................514

M Logun, G Simchick, Q Zhao, L Karumbaiah

BIOMATERIAL-MEDIATED CONTROL OF IMMUNITY FOR REGENERATIVE MEDICINE Slower Degradation of Poly (DL-lactide) Particles Provides Better Amelioration of Experimental Autoimmune Encephalomyelitis...........................................................................................................................................................................................515

E Saito, R Kuo, K Kramer, N Gohel, B Cheung, N Kaushal, L Shea

Poly(Ethylene Glycol) Hydrogels Functionalized with RGD Adhesive Ligands Modify Myeloid Cell Motility, But Not Phenotype .................................................................................................................................................................................................516

C Olingy, M Ogle, J García, A García, E Botchwey

Hydrogel Delivery of IL-10 Modulates Myeloid Cell Recruitment and Induces the Differentiation of Tolerogenic Cell Phenotypes...............................................................................................................................................................................................517

M. Sok, C. Olingy, K. Srithar, A. Garcia, E. Botchwey

Expansion of T Cells Via Poly(Dimethyl Siloxane)-based Fibrous Meshes with Tunable Rigidities....................................................518A. Dang, D. Bogdanowicz, S. Fernandes, J. Brown, H. Lu, L. Kam

Matrix Regenerative Nanoparticles to Improve the Tumor Microenvironment in Non-Small-Cell Lung Cancers ...........................519D. Seshadri, A. Ramamurthi

Mesenchymal Stem Cell Exosome Coated Scaffolds: An Immune Responsive Transplant for Tissue Regeneration ........................520N Su, Y Luo, Y Hao

Engineering Immunomodulatory Adhesive Hydrogel for Inflammation Control in Diabetic Wounds ...............................................521B. Saleh, H. Dhaliwal, E. Shirzaei Sani, R. Portillo-Lara, M. Amiji, N. Annabi

Precision-engineered Porous Polyurethane Resists Foreign Body Capsule Formation and Promotes Vascularization by Modulating Macrophage Response.............................................................................................................................522

L Zhen, B Ratner

An Injectable Liposome to Direct Macrophage Phenotype in Muscle Injury .........................................................................................523C Kraynak, L Suggs

Direct Irradiation Synthesis of Nanostructured Biointerfaces to Enhance the Longevity and Osseointegration of Titanium Implant Materials in Hard Tissue ...............................................................................................................................................524

A Barnwell, A Civantos, A Shetty, J Allain

Delayed Delivery of Simvastatin Increases In Vitro Osteogenesis and Modulates Inflammatory Macrophages................................525J. Alhamdi, M. Hurley, K. Spiller, L. Kuhn

Two-compartment, Magnetically Active Biomaterial System for Sequential Recruitment and Instruction of Cells .........................526A Tolouei, T Emi, S Madani, N Dulger, S Kennedy

Assessing the Immunomodulatory Properties of a Polyurethane Hydrogel Microsphere Protein Delivery System ..........................527E. Tawagi, S. Zhao, H. Cheng, P. Santerre

Heparin/Poly-L-lysine-coated 3D-printed PLGA Scaffolds As Drug Carriers for Local Immune Modulation in Bone Regeneration..........................................................................................................................................................................................528

T Nguyen, H Kim, A Dang, L Kam, J Lee

Designer Immune Organoids with T Cell Signals for Selective Enrichment of Antigen-specific B cells..............................................529A. Purwada, S. Shah, W. Beguelin, A. August, A. Melnick, A. Singh

Shape Specific Cerium Oxide Nanoparticles Modulate Macrophage Phenotype ...................................................................................530V Rakshe, S Sant

Iron Oxide Nanoparticles Inhibit Osteogenic Differentiation of Mesenchymal Stem Cells by Inducing M1 Macrophage Polarization...............................................................................................................................................................................531

L. Liu, R. Jin, J. Duan, L. Yang, H. Ai

Engineered Hydrogels to Manipulate Inflammatory Th17 cells in a Murine Model of Hypersensitivity Pneumonitis .....................532J Elmore, C Carter, A Bennett, A Redko, M Mosquera, A August, A Singh

BIOMATERIALS AND MEDICAL PRODUCTS COMMERCIALIZATION SIG Green vs. Traditional Electrospinning: Matching Fiber Properties and Cell Response ........................................................................533

C. Mosher, Z. Gong, H. Lu

Fabrication of Antibacterial Foam Dressing Including Silver-Carbon Composite for Effective Wound Healing..............................534Y Ko, T Yeo, J Lee, W Park, D Cho, O Kwon

BIOMATERIALS AND SCAFFOLDS FOR INTERFACIAL TISSUE ENGINEERING Designing a Chitosan-Based Thermosensible Hydrogel with high Bioadhesive and Mechanical Properties, and Compatible with Cell Therapy ......................................................................................................................................................................535

C Guyot, S Samaei, M Cerruti, S Lerouge

Umbilical Cord Blood Derived Fibrin Net and Platelet-Rich-Plasma Have Potency in Osteogenic Regenerative Medicine ..........................................................................................................................................................................................................536

K Baba, Y Yamazaki, Y Sone, Y Sugimoto, K Moriyama, T Sugimoto, K Kumazawa, A Takeda

Gradient Immobilization of Platelet-Derived Growth Factor on a Nanofiber Surface by Controlled Dopamine Polymerization for Tendon-Bone Tissue Engineering................................................................................................................................537

M. Sanjeesh, J. Lee, S. Lee, H. Shin

Effects of Scaffold Geometry on Development of S. aureus Tolerance to Antibiotic Treatment ..........................................................538T Spoonmore, J Cassat, J Wenke, S Guelcher

Mineral-Based Approach for Modulation of Stem Cell Fate ....................................................................................................................539A. Brokesh, L. Cross, J. Carrow, B. Vonasek, A. Gaharwar

BMP-2 Modified Nano-Fibers for Soft Graft-Bone Integration During Ligament Reconstruction .....................................................540D Gadalla, A Goldstein

Abaca Cellulose-based Fibers for MSCs Culture .......................................................................................................................................541R De Guzman, H De Guzman

Surface Modification of Biodegradable Porous Magnesium-Based Bone Implant.................................................................................542V. Posada, A. Shetty, A. Civantos, P. Fernandez-Morales, J. Ramírez, J. Allain

Surface Nanomodification of Porous Titanium Scaffolds to Improve in vitro Bone Osseointegration ................................................543A. Civantos, A. Shetty, S. Arias, R. Pino, C. Dominguez, Y. Torres, J. Rodriguez, J. Allain

Effects of Copper on Physical, Mechanical, and Biological Properties of Brushite Cement .................................................................544H. Cummings, W. Han, K. Elkwae, S. Vahabzadeh, S. Elsawa

Development of N-Oxalylglycine-Conjugated Hyaluronic Acid for Therapeutic Angiogenesis............................................................545A DeMaria, K Webb, J Lee

Bone Tissue Engineering Scaffolds based on Polyampholyte Hydrogels with Conjugated SIBLING Proteins ..................................546M Bernards, C Qin, S Haag

Core-shell Nanofibers Modified by Cold Atmospheric Plasma (CAP) for Tissue Engineering Applications .....................................547Y Zhou, M Wang, T Webster, M Keidar

Fabrication of Cell Laden Fiber/Hydrogel Construct for Ligament Tissue Engineering ......................................................................548Y Jeong, C Park, J. Kim

BIOMATERIALS EDUCATION SIG Building Critical Skills in Biomaterials Applications and Medical Device Development: An Established Curriculum Linking Engineering, Commercialization and Clinical Adoption .......................................................................................549

F. Schoen, J. Reilly

Effect of Shot Peening on Stress Corrosion Behavior of Biodegradable Magnesium WE43.................................................................550T. Patil, M. Sealy, F. Bobaru

BIOMATERIALS FOR CARDIOVASCULAR REGENERATION Predicting Rupture Potential of Abdominal Aortic Aneurysms with Gold Nanoparticles Targeting to Degraded Elastin ..............................................................................................................................................................................................................551

X. Wang, S. Karamched, V. Parasaram, B. Lane, S. Lessner, J. Eberth, N. Vyavahare

Bioprinted Patch with Cardiac Extracellular Matrix and Human Cardiac Progenitor Cells for Heart Regeneration .....................552D Bejleri, M Davis

Polyethylene Glycol-Conjugated Peptide Promotes Therapeutic Angiogenesis in Diabetic Hindlimb Ischemia ................................553H Park, S Kim, Y Son, H Hong, S Cho

Delivery of Nitric Oxide and Antioxidant via Nanoparticles for the Treatment of Peripheral Artery Disease ..................................554D Le, A Kuriakose, T Nguyen, D Nguyen, K Nguyen, S Acharya

Methacrylated PGS-Gelatin 3D Honeycomb Patterned Scaffolds for Cardiomyocyte Delivery and Maturation ..............................555V. Morris, M. Huang, S. Bae, A. Andukuri, Y. Yoon

Nanofiber-hydrogel Composite Material for the Treatment of Acute Myocardial Infarction ..............................................................556C Chang, X Li, H Mao, T Fukunishi, D. Bedja, M. Seu, J. Cua, J. Yan, M. Yang, N. Hibino, H. Mao

C-Jun N-terminal Kinase Gene Silencing to Stimulate Elastic Matrix Regenerative Repair in a Proteolytic Disorders..........................................................................................................................................................................................................557

D. Ortiz-Serrano, A. Camardo, A. Ramamurthi

Mesenchymal Stem Cell Response on Acellular Porcine Pericardium in a Subcutaneous Rat Model.................................................558J. Go, R. Khorramirouz, C. Noble, S. Jana, D. Morse, E. Maxson, A. Lerman, M. Young

Biocompatible Nanofiber Yarns for Cardiac Muscle Tissue Regeneration .............................................................................................559N. Arthi, S. Jahnavi, R. Verma

Engineering Conductive Fibrous Patches for Cardiac Tissue Regeneration...........................................................................................560B. Walker, C. Hsiang Yu, R. Portillo-Lara, E. Shirzaei Sani, W. Kimball, N. Annabi

Engineering Blood Vessels through Dynamic Culture of Biomimetic Scaffolds .....................................................................................561A. Goins, J. Allen

Nano-spheres and -rods for Targeting Dysfunctional Endothelial Glycocalyx .......................................................................................562M Cheng, P Prabakaran, R Kumar, S Sridhar, E Ebong

Tissue Engineered Living Aortic Heart Valve Roots: In vitro Characterization and Revitalization ...................................................564M Casco, D Simionescu

Designing a Bilayer Small Diameter Vascular Prosthesis from Collagen and Tropoelastin Yarns in a Knitted and Electrospun Tissue Engineered Scaffold......................................................................................................................................................565

F. Zhang, Y. Xie, O. Akku, M. King

BIOMATERIALS FOR REGENERATIVE ENGINEERING APPLICATIONS Fabrication of Methylmethacrylamide and 2-hydroxyethyl methacrylate Hydrogel Injectable Filler for Soft Tissue Engineering .....................................................................................................................................................................................................566

C Heo, K Lee, J Shim, S Kim

Pathology-targeted Cell Delivery via Injectable Microscaffold Capsule Mediated by Endogenous TGase ........................................568C. Qi, Y. Du

Self-assembled Nanocomposite Hydrogels Driven by Bisphosphonate-Mg2+ Coordination Regulate the Differentiation of Encapsulated Stem Cells and Promote in-situ Bone Regeneration............................................................................569

K Zhang, S Lin, Q Feng, G Li, L Bian

Novel Tannic Acid Implant Material for Tissue Regeneration and Anti-Cancer Activity following Breast Cancer Treatment ........................................................................................................................................................................................................570

A. Baldwin, K. Williams, B. Booth

Cell Sheet on Electrospun Fibrous Mesh for Tissue Regeneration...........................................................................................................571L. Jin, Z. Ren, Q. Cai, X. Yang

An Ice-Templated Chitosan-based Ureteral Stent ......................................................................................................................................572P. Divakar, K. Yin, U. Wegst

Growth Factor-free Bioactive Nanocomposite Promotes Bone Regeneration in vivo ............................................................................573A Patel, S Zaky, E Beniash, C Sfeir, H Li, S Velankar, Y Wang, D Stolz, S Sant

Design, Structure, Material Strength and Release Profile of Dissolvable Microneedle Patches ...........................................................574M Mofidfar, M Prausnitz

Biomimetic Mesh Scaffold Containing Human Lung Fibroblast-Derived Extracellular Matrix and Inorganic Minerals for Bone Regeneration ...................................................................................................................................................................575

J. Lee, K. Park

Nanosilver and Apatite Mounted Biodegradable Microspheres for Bone Regeneration .......................................................................576P. Wei, Q. Cai, X. Yang

Bio-inspired Cell Culture Platforms for Improved Epidermal Regeneration in vitro ...........................................................................577D. Davis-Hall, V. Nguyen, T. D’Ovidio, E. Tsai, G. Bilousova, C. Magin

Characterization and 3D Printing of Gelatin Methacrylate Resin ...........................................................................................................578W Surbey, N Chartrain, C Williams, A Whittington

Tailorable PEGDMA Scaffold to Improve Cell-Based Regenerative Therapies.....................................................................................579H. Barnett, A. Whitehead, J. Newman, M. Caldorera-Moore

Targeted Delivery of Nanoparticles to Emphysematous Lungs: Systemic versus Local Therapy ........................................................580V Parasaram, X Wang, N Vyavahare

Novel 3D Hybrid Nanofiber Aerogels for Cranial Bone Regeneration ....................................................................................................581J Xie, S Kumar, H Wang

Preventing Hypoxia-induced Beta Cell Death and Dysfunction via Oxygen-generating Microbeads..................................................582J. Liang, M. Coronel, M. Dang, C. Stabler

Precise Control Delivery of Magnesium Ions thru Sponge-Like Monodispersed PLGA/nano-MgOAlginate Core-Shell Microsphere Device to Enable in-situ Bone Regeneration ...............................................................................................................583

Z. Lin, J. Wu, Y. Zhao, K. Cheung, F. Leung, P. Chu, K. Yeung

An Innovative Laboratory Procedure to Expand Chondrocytes with Reduced Dedifferentiation.......................................................584Y Mao, T Hoffman, A Wu, J Kohn

Osteogenic and Adipogenic Differentiation of Human Mesenchymal Stem Cells on Tailorable Hydrogel Scaffolds ........................585R. Eddy, I. Pursell, H. Barnett, A. Whitehead, M. Caldorera-Moore, J. Newman

Investigation of the Cell-loading and Differentiation Potential of Keratin-based Microparticles ........................................................586M. Thompson, M. Van Dyke

Induce BMSCs Differentiate into Neural Cells with Synergistic Multiple Factors.................................................................................587W. Jing, Q. Cai, X. Yang

A Pro-Angiogenic Peptide-Tethering Platform Using Biotinylated Tyrosine-Derived Polymeric Fiber Mats....................................588A. Pastino, M. Guvendiren, R. Goyal, O. Freeman, Y. Mao, K. Dube, J. Kohn

The Biological Effect on Physical Modified Chitosan Nanofiber Scaffolds .............................................................................................589B Gu, S Park, C Kim

Integrating Experiments and MD Simulations to Determine the Degradation of poly-4-hydroxybutyrate for Surgical Suture Applications.........................................................................................................................................................................590

R Vaid, M Pasquinelli, M King

Ultrasound-Derived Mechanical Loading with Cell Therapy for Bone Repair ......................................................................................591F. Assanah, J. Veronick, P. Maye, Y. Khan

Vascular Endothelial Growth Factor Delivery from Functionalized Bone Allografts to Enhance Bone Repair ................................592K. Grassie, F. Assanah, Y. Assanah

3D Aligned Fibrous Scaffold on a Small Diameter Vascular Format ......................................................................................................593F. Ng, Y. Ong, H. Gustafianto, L. Tan

A General Method for Assembling Cells into Macroscopic Scaffold-free Tissues ..................................................................................594L Yang, K Lee

Preparation and In Vitro Characterization of an Integrated Graft System for Regenerative Engineering ........................................595M Barajaa, L Nair, C Laurencin

Dynamic 3D Hydrogel Scaffolds for Tissue Regeneration Applications ..................................................................................................596R Hegab, H Barnett, M Caldorera-Moore, A Heimbuck, J Newman

Raman Spectroscopic Analysis of Plant Cell Wall in Normal and Diseased Sunflower.........................................................................597M Roy, B Kontz, F Mathew, A Prasad

Synthesis and Evaluation of Poly(octamethylene citrate β-glycerophosphate) (POC-βGP) for Bone Regeneration ..........................598Q Li, J Guo, J Chen, J Yang, Y. Zhu

BIOMATERIALS PLATFORMS FOR SCAFFOLD-FREE TISSUE ENGINEERING Effect of Polyelectrolyte Molecular Weight on Adipocyte Spheroid Maturation and Retention atop Amphiphilic Coatings ...........................................................................................................................................................................................................599

S. Fitzgerald, J. Cobb, A. Janorkar

ECM Protein Shrink-Wrapped Cells Demonstrate Enhanced Integration into Corneal Endothelium ...............................................600R. Palchesko, A. Feinberg

Microstructure of Gelatin Colloidal Gel Controls Endothelial Cell Organization .................................................................................601S. Nair, D. Sarkar

Study of Cellular Self-Assembly Behaviors on Hydrocarbon Fluidic Substrates ...................................................................................602M Maruyama, Y Tada

Formation of Stem Cell Aggregates via Surface-Mediated Self-Assembly ..............................................................................................603K Barteau, A Xie, W Murphy

BIOMATERIAL-TISSUE INTERACTION SIG Copper Doped Tricalcium Phosphate; Phase Composition and In Vitro Interaction with Osteoblast Cells ......................................604

W. Han, H. Cummings, S. Fleck, S. Vahabzadeh, S. Elsawa

Histological Changes in Swine Subcutaneous Tissue Surrounding Commercial Continuous Subcutaneous Insulin Infusion (CSII) Catheters with a PTFE Cannula .......................................................................................................................................605

A. Khalf, D. Diaz, A. Dinesen, G. Eisler, C. Loeum, M. Torjman, P. McCue, P. Strasma, J. Joseph

“Ruffled Border” Formation on a CaP-free Substrate: a First Step towards Osteoclast-Recruiting Bone-Grafts Materials able to Re-Establish Bone Turn-Over ........................................................................................................................................606

S Fung, A Merolli, S Murthy, E Pashuck, Y Mao, X Wu, J Steele, D Martin, P Moghe, T Bromage, J Kohn

Development of an Easy-to-use Microneedle Patch for Collection of Dermal Interstitial Fluid ...........................................................607C Kolluru, M Williams, M Prausnitz

CANCER NANOTECHNOLOGY Microvesicles Contribute to Matrix Remodeling and Cancer Heterogeneity .........................................................................................608

S Schwager, L Hapach, F Bordeleau, M Antonyak, R Cerione, C Reinhart-King

Natural Killer Cell Engineering for Therapeutic Targeting of Metastases in the Tumor Draining Lymph Nodes............................609Z Zhang, D Liu, J Greenlee, F Yu, N Ortiz-Otero, T Cao, M King

A Mechanistic Study of Anti-HIV Activity and Cancer Registry Match Investigation in Laboratory Drug 2- Indolinones Show Record Linkage Among Them Many Interesting Leads Evaluation ........................................................................610

R. Hajare, R. Paranjape

Hydrophobic Core, pH-responsive ABC Triblock Copolymers for Formulation of Stabilized siRNA Polyplexes.............................611M Stokan, M Jackson, S Bedingfield, T Werfel, C Duvall

Development of a Histotrpisy Agent using Host-Guest Interaction..........................................................................................................612T Rehman, E Vlaisavljevich, Y Yuksel Durmaz

Influence of Gold Nanoparticle Size on Uptake into Different Ovarian Cancer Cell Lines measured by Spectral Photon-counting CT .......................................................................................................................................................................................613

M Moghiseh, D Kumar, R Aamir, P Sykes, C Low, A Butler, N Anderson

Synthesis and Characterization of Lipid Nanoparticle Formulation of a Poorly Soluble, Highly Potent, Novel Synthetic Analog of Curcumin for Cancer Therapy ..................................................................................................................................614

A. Pradhan, S. Mishra, A. Surolia, R. Srivastava, D. Panda

IR820-Loaded Poly(lactic-co-glycolic acid) Nanoparticles for Photothermal Cancer Therapy ............................................................615D. Valcourt, S. Peden, E. Day

Glutathione-sensitive Nanoparticles for Lung Cancer Treatment ...........................................................................................................616R Iyer, D Padanilam, D Zhukova, C Xu, K Nguyen, Y Hong

In vivo Assessment of Toxicity of Gold Nantheranostic Agent .................................................................................................................617N El-Baz, K James, R Chauhan, D Malik, B Nunn, A Switala, A El-Baz, R Keynton, P Bates, T Malik, M O’Toole

Magnetically Triggered Drug Release from Nanoparticles .......................................................................................................................618E Fuller, H Sun, B Sumerlin, C Rinaldi

Spectral Photon-Counting CT imaging of Gold Labelled Monoclonal Antibody Drug Delivery to Raji and HER2 Positive Beast Cancer Cells – A Phantom Study.........................................................................................................................................619

C. Lowe, A. Raja, M. Moghiseh, J. Lewis, A. Butler, N. Anderson

Cancer-exosome-mimetic Nanovesicles for Homotypic Cell Recognition................................................................................................620G Abbott, C Mao

Ultrasound Enhanced Release of a Model Drug from Transferrin-Coupled Liposomes .......................................................................621N Alsawaftah, P Kawak, G Husseini

Acoustically Activated Accumulation and Release from Estrone-Targeted Liposomes in the Treatment of Breast Cancer ..............................................................................................................................................................................................................622

N Salkho, R Vitor, A Martins, M Al Sayah, G Husseini

Novel Synthesis of Iron-based Metal-Organic Framework for Site-specific Doxorubicin Delivery .....................................................624M Ibrahim, R Sabouni, G Husseini

Ultrasound Enhanced Release of Albumin Coupled Liposomes Used for Breast Cancer Treatment ..................................................625G Husseini, N Awad, V Paul, M Al-Sayah

End-to-end Clicking of Gold Nanorods for Controlling Cellular Uptake................................................................................................626Y Son, H Yoo

Targeted Immunomodulation of CD8+ T Cells with F(ab’)2-conjugated Liposomes ............................................................................627C Park, J Moon

CARDIOVASCULAR BIOMATERIALS SIG Tissue-engineered Atherosclerosis Model in a Physiological Bioreactor .................................................................................................628

J Chen, G Alexander, C Bae, P Hwang, C Zhang, Y Yoon, P Sethu, B Brott, J Kim, H Jun

A Fluoroscopic, Mechanically Tunable, Bioresorbable Synthetic Polymer for Cardiovascular Applications ....................................629J Wright, A Nguyen, J Wang, R Jaquiss, T Welch

How to Keep the Native Structure and Bioactivity of the Acellular Biological Scaffolds for Tissue Regeneration............................630T. Yamaoka, H. Yamanaka, A. Mahara, N. Morimoto

Proangiogenic Peptide Scaffolds for Myocardium Regeneration .............................................................................................................631P. Nguyen, A. Chirayath, B. Sarkar, V. Kumar

Crosslinked Poly(acrylic acid)-Erythrocruorin Nanoparticles: A Highly Stable Blood Substitute ......................................................632K. Spivack, N. Comolli, J. Elmer

The Effect of Thermal Treatment on the Local Compressive Strength of a Polydioxanone Braided Stent ........................................633F. Zhao, L. Wang, F. Wang, M. King

Schwann Cell Monolayers Naturally Enhance Cardiomyocyte Maturation ...........................................................................................634J Soucy, D Diaz, A Koppes, N Annabi, R Koppes

Natural Polymers of Bacterial Origin for Cardiac Regeneration .............................................................................................................635P Dubey, E Humphrey, M Stevens, C Terracciano, S Harding, I Roy

Superhemophobic Titania Nanotube Array Surfaces for Blood Contacting Medical Devices ..............................................................636K Popat, K Bartlett, S Movafaghi, A Kota

CURRENT APPROACHES TO TREAT CARDIOVASCULAR CALCIFICATION Examining Cellular Mechanics In Vascular Calcification.........................................................................................................................637

N Nguyen, C Simpson

Alginate Hydrogels as an Injectable Cell Delivery System ........................................................................................................................638V. Mullins, C. Simpson

Regulating the Phenotypic Switch of Smooth Muscle Cells in Vascular Calcification Using a Protein- Based Inhibitor...........................................................................................................................................................................................................639

K Parker, K McArthur, J Mosier, A Kay, J Stewart, C Simpson

Nanoparticle Targeting to Reverse Aortic Calcification in a Modified Mouse Model of Adenine-Induced Chronic Kidney Diease..................................................................................................................................................................................................640

S Karamched, X Wang, N Vyavahare

AGE/RAGE Signaling in Diabetes-Mediated Vascular Calcification in Vascular Smooth Muscle Cells ............................................641A Kay, B Rushing, L Simpson, J Stewart

DENTAL/CRANIOFACIAL BIOMATERIALS SIG Methylcellulose Based Injectable Gel Scaffolds Incorporating BMP-9 coated Chitosan Microparticles for Bone Regeneration Applications.............................................................................................................................................................................642

B Gaihre, C Jayasuriya

Understanding the Surface Performance of Titanium Dental Implants: A Comprehensive in-vivo and in-vitro Study ................................................................................................................................................................................................................643

D Rodrigues, K Palmer, T Wilson, P Valderrama, F Wang, S Sridhar

Mineralized E1001(1k) Scaffolds for Bone Tissue Regeneration: The Effect of Dicalcium Phosphate Dihydrate Composition on Human Dental Pulp Stem Cells ........................................................................................................................................644

W Chang, S Saxena, A Fakhrzadeh, E Pashuck, J Kohn

Incorporation of Iron to Titanium Nanotube; Processing, Characterization, and In Vitro Cellular Interaction...............................645M Duvvuru, S Vahabzadeh

Additive Effects of Biomolecular Supplementation in Mineralized Collagen Scaffolds for Bone Regeneration ................................646A Tiffany, B Harley

PEEK Composites Embedding Natural Silica Fibers and Lithium Zirconium Silicates .......................................................................647J Souza, R Curtarelli, P Monich, M Fredel, B Henriques, F Silva

Osteogenic Potential of Machined, Resorbable Blast-Textured, and Laser-Etched Titanium Dental Implant Surfaces............................................................................................................................................................................................................648

A. Nelson, T. Wick

Effect of Hot Isostatic Pressure Treatment of Ti6Al4V Laser Sintered Constructs on Osteogenic Differentiation of Mesenchymal Stem Cells Varies with 3D Geometry ..................................................................................................................................649

M Berger, T Jacobs, B Boyan, Z Schwartz

Porcine Collagen Anorganic Bone Composite for Guided Bone Regeneration in a Canine Intrabony Defect Model .......................650H Chen, S Li

Novel Resorbable Reinforced Collagen Membrane in Ridge Augmentation ..........................................................................................651M Hu, N Lee, H Chen, S Li

A Pre-hydrated Bovine Collagen-Based Tissue Membrane for Guided Bone Regeneration: In Vitro and In Vivo Characterization Studies ...............................................................................................................................................................................652

S Li, N Lee, H. Chen

Effects of Dynamic Loading on Orthodontic Tooth Movement ................................................................................................................653Q Li, Z. Liao, J. Grove, O. Dalci, J. Chen, K. Zheng, J. Zhong, M. Derendeliler, M. Swain

Peptide-Modified Hydrogels to Enable Salivary Cell Co-Cultures ..........................................................................................................654M Martinez, S Pradhan-Bhatt, R Witt, M Farach-Carson, D Harrington

DEVELOPMENT AND MANUFACTURE OF SILK-BASED TISSUE ENGINEERED DEVICES: FROM BASIC SYSTEMS TO CLINICAL USE Comparative Study of Formic Acid Fabricated Silk Materials ................................................................................................................655

X. Hu

Biomimetic Spider Silk Spinning ..................................................................................................................................................................656J Johansson, A Rising

Reinforcement Effect of Mono- and Multi-Filament 3D Silk Fabric Structures within the Hydrogel Matrix....................................657K. Lee, C. Ki, J. Kim

DRUG DELIVERY SIG Microneedle Patches for Sustained Release of Contraceptive Hormones................................................................................................658

R. Terry, W. Li, M. Prausnitz

Nanofiber-Based Analgesic Bandages for Localized Treatment of Neuropathic Pain ...........................................................................659M Patterson, B Janet, M Skoff, C Tison

A Cell Membrane-Based Nano Device for Intravascular Targeting of Leukocytes and Therapeutic Delivery to Inflammation...................................................................................................................................................................................................660

Y Luo, F Wang, C. Liu, W. Hou, Y. Zhang, J. Pang, J. Xie, J. Xiong, D. Liu, L. Zheng

Chemical Modification of Alginate for Targeted Drug Delivery ..............................................................................................................661K Enck, S Banks, H Yadav, M Welker, E Opara

Thiol Grafted Biodegradable Polyurethane Membrane for Sustain and Stable Drug Delivery System ..............................................663E Song, Y Seong, H Kim, S Jeong, J. Kim

Development of a Multi-functional Wrap for Bone Allograft Revitalization ..........................................................................................664T. Walker, A. Kishan, E. Cosgriff-Hernandez, T. Wilems

In Vitro Evaluation of Thermally Induced Chitosan Gel-paste Use for Local Antibiotic Delivery ......................................................665L Pace, J Jennings

Highly Efficient Non-viral VEGF Gene Delivery to Human Mesenchymal Stem Cells by Lipid Based Nanoparticles .....................666M. Zhai, C. Mao

Ultrasound- and Protein-Receptor-Targeting in Cancer Treatment .......................................................................................................667R Turki, R Vitor, A Martins, M Al-Sayah, G Husseini

Development of the pH-Induced Secondary Structure Conversion Mixed Micelles in Anticancer Therapy ......................................668F Shih, Y. Huang, C. Chen, Y. Chiang

Stretchable, Anti-Bacterial Hydrogel Activated by Large Mechanical Deformation.............................................................................669W Ballance, Y Seo, K Baek, M Chalifoux, D Kim, H Kong

ROS-Triggered Degradable Iron-Chelating Nanogels: Safely Improving Iron Elimination in Vivo ...................................................670Z Liu, M Xiong

ENGINEERED BIOMATERIALS FOR NEURAL APPLICATIONS Mechanical and Architectural Characterization of Novel Peripheral Nerve Injury Repair Scaffolds ................................................671

M Wall, C Lacko, I Singh, C Rinaldi, C Schmidt

Topical Nucleophilic Gel Prevents Pesticide Induced Excitotoxicity and Neural Dysfunction .............................................................672K Thorat, S Pandey, S Chandrashekharappa, V. Nikitha, P Vemula

Fabrication and Characterization of Multi Interpenetrating Networks as a Potential 3D Model for the in vitro Study of Human Astrocytes...........................................................................................................................................................................673

R. Van Drunen, E. Tsai, A. Jimenez-Vergara, D. Munoz-Pinto

Nanoparticle Crosslinkers: Increasing the Efficacy of Surface Modification for Neural Implants......................................................674K. Woeppel, X. Cui

Reducing Microelectrode Shaft Size and Including a Soft, Permeable Base Coating Improves UEA Biocompatibility..............................................................................................................................................................................................675

B Velagapudi, M Polei, P Tresco

Hyaluronic Acid Carbon Nanotube Composite Nanofibers Increase Neurite Growth in vitro ............................................................676E. Steel, J Azar, M Taleb, H Sundararaghavan

A Modular Approach to Construct Multi-Biofunctional and Electrically Conductive Surface............................................................677J Mao, Z Zhang

Development and Biodegradability Evaluation of Poly (L-lactic acid) and Poly (ε-caprolcatone) Blends as Self-Expanding Surgical Patches to Advance Prenatal Fetoscopic Myelomeningocele Repair.....................................................................678

R Tatu, M Oria, J Peiro, C Lin

Three-Dimensional Culture Systems to Link Brain Development to Behavior ......................................................................................679A. Magarinos, S. Pedron, B. Harley, D. Pfaff

A Comparison of the FBR of Tethered and Untethered UEAs in Rat Cortex ........................................................................................680M Polei, B Velagapudi, P Tresco

Electrospun Collagen Scaffold for Peripheric Nerve Regeneration .........................................................................................................681C. Rivera Martinez, J. Mendez, J. Almodovar

Implantable Peptide-Hydrogel Drug Delivery System for Treating Glioblastoma Multiforme............................................................682A Gregory, A Alexander-Bryant, E Miller

Nanomaterials for Immunotherapy Against Multiple Sclerosis/Experimental Autoimmune Encephalomyelitis (EAE) ...............................................................................................................................................................................................................683

A Hassani Najafabadi, R Kuai, A Schwendeman, J Moon

Fabrication of Functional Nanocomposites from Natural Biomaterials including Nanocellulose, Conductive Melanin, and Photosynthetic Complexes .....................................................................................................................................................684

B Shim, T Eom, S Seunghyeon Lee, J Heo

Synthetic Aligned Nanofibers Functionalized with GYIGSR Increase the Rate of Neural Differentiation of Mouse Embryonic Stem Cells ....................................................................................................................................................................................685

E Silantyeva, W Nasir, J Carpenter, O Manahan, M Becker, R Willits

ENGINEERED MICROENVIRONMENTS TO MODEL DISEASE Fabrication of Vascularized 3D-Cancer Models with Dense Stroma Using Collagen Microfibers.......................................................686

K. Natsuko, M. Komeda, M. Matsusaki

Protease-Degradable Polyethylene Glycol Maleimide Microgels for Studying Lymphoid Tumor Growth and Survival............................................................................................................................................................................................................687

R. Stephenson, K. Lai, A. Singh

Collagen Amount Modulates Cardiac Function: iPSderived Myocardial Fibrosis Models by Sedimentary Culture using Collagen Microfibers............................................................................................................................................................................688

K. Nishi, M. Komeda, J. Lee, S. Miyagawa, Y. Sawa, M. Matsusaki

Reconstituting Microvascularized Muscle Satellite Cell Niche on a Chip ...............................................................................................689Y Lee, S Ahn, J Yom, E Shin, J Choi, Y Jang, Y Kim

Processing of Chitosan-Hyaluronic Acid Scaffolds to Produce an Optimized Breast Cancer Tumor Microenvironment ..........................................................................................................................................................................................690

Z. Wang, K. Xu, I. Arias, M. Le, A. Khaled, S. Florczyk

Influence of Biomaterial Scaffold Properties on Breast Cancer Cell Morphology and Proliferation ..................................................691M Le, Z Wang, B Ding, K Ellett, S Florczyk

Influence of Material Selection on Tumor-Macrophage Interactions in a Tissue Engineered Breast Cancer Model ........................692S. Holt, D. Alge

Characterization of Laminin and Fibronectin-Driven Matrix Remodeling Kinetics in Liver Models.................................................693A. Mazzocchi, R. Huntwork, S. Soker, A. Skardal

Engineered Matrices for Studying the Effects of Tissue Stiffness on Breast Cancer Metastasis ..........................................................694J. Al-Saleh, C. Gomillion

3D Multiple Cell Spheroids in Silica Coated Fungi Network Scaffolds ...................................................................................................695X Qu, C Mao

Redirection of Human HER2-positive Breast Cancer Cells ......................................................................................................................696A Frank-Kamenetskii, B Booth, L. Staccioli, J. Park

Long-term Ex-vivo Survivability of Bone Tissue for Tissue Experimentation Platform .......................................................................697A Chakraborty, A Prasad

High-throughput Miniaturized Fibrotic Micro-niches for Anti-fibrotic Drug Screening Targeting Collagen Fiber-mediated Mechanotransduction....................................................................................................................................................................698

Z You, L Zhou, L Liu

Micromolded Gelatin Hydrogels Crosslinked with Laminin for Disease on a Chip Applications ........................................................699I. Claure, E. Jones, J. Reda, R. Besser, M. Ishahak, A. Agarwal

Shape-Specific Nanoceria Effectively Mitigate Oxidative Stress-Induced Calcification of Patient-Derived Valvular Interstitial Cells ..............................................................................................................................................................................................700

Y Xue, V Sant, S Sant

Using 3D Material Cytometry (3DMaC) to Assay Cell Behavior in Microhydrogels.............................................................................701K Parratt, J Jeong, P Qiu, K Roy

Development of a Multi-Layer Microvascular Airwayon-a-Chip Microfluidic Device..........................................................................702J Mejías, M Nelson, K Roy

ENGINEERING CELLS AND THEIR MICROENVIRONMENTS SIG Bioactive Ovarian Hydrogels Provide a Novel Biomaterial for In Vitro Follicle Maturation...............................................................703

M Buckenmeyer, Z Xian, M Sukhwani, K Orwig, B Brown

Mesoporous Silicate Nanoparticles/3D Nanofibrous Scaffold-based Dual-drug Delivery for Bone Tissue Engineering .....................................................................................................................................................................................................704

H. Sun, Q. Yao, Y. Liu

Engineering Hydrogels to Maintain Differentiation Phenotype of Mesenchymal Stem Cell Spheroids ..............................................705K Leach, B Hung, S Ho

The Delivery of Electrical Stimulation through Conductive Membrane Induces Human Keratinocyte Proliferation and Increases the Production of Keratins 5 and 14 ....................................................................................................................................706

Z Zhang, H Park, Y Douville, M Rouabhia

Cell Traction Force Generated by Macrophages is Affected by Polarization Status and Polyacrylamide Gel Stiffness ............................................................................................................................................................................................................707

P. Sharma, E. Harmon, J. Lee, K. Egland, D. Engebretson, E. Gnimpieba

Toward Development of the CellWell - A Novel Micropatterned Semi-3D Cell Culture Scaffold. ......................................................708T Ryther, R Saraswat, Z Zhu, S Wood

Optimization of Silk Substrate and Fibronectin Coating for Salivary Niche Regeneration ..................................................................709J Pearson, H Wang, T Guda, D Dean, X Chen, J Ong, C Yeh

ENZYME-ASSISTED BIOMATERIALS FABRICATION AND MODIFICATION FOR BIOLOGICAL APPLICATIONS In-Gel Fluorescent Peptide Zymography for the Analysis of Cell Secreted Proteases ...........................................................................710

A. Deshmukh, J. Weist, J. Leight

Tailorable Regenerating Hyaluronan Polymer Brushes: A Novel Class of Biointerfaces Generated By Hyaluronan Synthase ...........................................................................................................................................................................................................711

J Curtis, J Faubel, W Wei, H Selvakumar, N Greenwald, J Washburn, P Weigel

Examination of Exosome Purification Method Derived from Culture Supernatant of the Mesenchymal Cells from Human Ilium Bone(hBMCs) Which We Chose, and Its Bone Differentiation Inducibility ...................................................................712

Y Sugimoto, Y Yamazaki, K Moriyama, K Baba, Y Sone, T Sugimoto, K Kumazawa, A Takeda

FABRICATION AND 3D PRINTING OF TISSUE ENGINEERING SCAFFOLDS Optimizing 3D Printability in Hydrogel Bioinks Through Compositional and Rheological Analysis..................................................713

L Miller, D Chimene, A Gaharwar

Three-dimensional Biodegradable Scaffolds: A Novel Approach for Tissue-Engineered Reconstruction of Complex Maxillary Defects ............................................................................................................................................................................................714

J Shim, H Han, J Lee, W Yun, C Baek, J Rhie, D Cho

Direct 3D-Printing of Thiol-ene Crosslinked HA Hydrogels with Tunable Mechanics for Tissue Repair ..........................................715J. Galarraga, L. Ouyang, C. Highley, J. Burdick

Assessment of Integration Between 3D Printed Stiff Hydrogels via Stereolithography and Infilled Soft Hydrogels.........................716A. Muralidharan, R. McLeod, S. Bryant

Full Factorial Design of Hierarchical 3D Scaffolds for Bone Tissue Engineering ..................................................................................717A. Yousefi, J. Liu, S. Koo, M. Duley, J. Zhang, P. James

Phage-selected Osteogenesis-inducing Peptides ..........................................................................................................................................718K. Sunderland, C. Mao

3D Printed Scaffolds Based on Calcium Phosphate and Hydroxypropyl Methylcellulose Ink for Bone Tissue Regeneration ...................................................................................................................................................................................................719

F Guastaldi, J Rodriguez-Chanfrau, T Pelizaro, M Silva, E Pizoni, J Carvalho, A Guastaldi

Cell-laden Hydrogel Microspheres Using 3D Printed Microfluidics ........................................................................................................720R Ramos, S Suvarnapathaki, S McLoughlin, S Sawyer, P Soman

Yield Stress as a Critical Material Attribute in Extrusion Bioprinting ...................................................................................................721T Jiang, J Kinsella

Proliferation of HDFs on Gelatin Based Three-Dimensional Scaffolds by 3D Bioprinting ...................................................................722D Choi, S Park, B Gu, S Chung, C Kim

Effective Bone Tissue Regeneration Using Silk Fibroin Nanofiber/PGA Hybrid Scaffolds Fabricated by Electrospinning and 3D Printing Techniques .............................................................................................................................................723

T Yeo, O Kwon, Y Ko, J Lee

GLYCOMATERIALS Composite Glycopeptide Nanofiber-Poly(Ethylene Glycol) Hydrogels to Probe Extracellular Lectin-Glycan Interactions......................................................................................................................................................................................................724

A Restuccia, I Baek, M Molinaro, G Hudalla

Chondroitin Sulfate Glycosaminoglycan “Click” Hydrogel for Neural Stem Cell Maintenance and Differentiation .......................725M. Sun, P. Chopra, G. Boons, L. Karumbaiah

Biomimetic Proteoglycans Enhance Type I Collagen Fibrillogenesis Mediated by Chondroitin Sulfate ‘Bristles’............................726C Moorehead, K Prudnikova, M Marcolongo

Engineering Sugar Polymers as Highly pH-responsive Nanoscopic Assemblies.....................................................................................727W. Du, S. Maiti

Development of Cell Surface Mucin Mimetic Glycopolymers...................................................................................................................728D. Honigfort, M. Zhang, K. Godula

Comparison of MRSA Biofilm Inhibitory Properties of Commercially Available Veterinary Wound Sprays and Hydrogels.........................................................................................................................................................................................................729

R. Awais, B. Barr, J. Jennings

Characterization of Poly-Amido-Saccharide Secondary Structure by Molecular Dynamics Simulations ..........................................730A Balijepalli, S Chin, Q Lu, C McKnight, J Straub, M Grinstaff

HARNESSING MATRIX BIOLOGY TO CONTROL CELL FATE The Impact of Free Protein Extracted From BM-HPME® on Bone Marrow Cell Proliferation and Differentiation .......................731

S. Miar, S. Griffey, T. Guda

Mapping 3D Mechanical Strains During Tissue Formation with a Novel Fibronectin-based Nanomechanical Biosensor..........................................................................................................................................................................................................732

D Shiwarski, A Tsamis, Q Jallerat, J Tashman, M Blundon, J Szymanksi, B McCartney, A Feinberg

In vitro Formation of Three Dimensional Biliary Trees within Decellularized Liver Extracellular Matrix Hydrogels.........................................................................................................................................................................................................733

P Lewis, J Su, R Green, G Alpini, B Sosa-Pineda, R Shah

Matrix Diameter Controls Migration Speed Through Focal Adhesion Molecular Arrangement ........................................................734D Bowers, J Brown

Cell-Generated, Out-of-Plane Normal Forces Strongly Correlate to In-Plane Shear Forces................................................................735O. Banda, R. Taitano, J. Slater

Long Term Maintenance of Primary Mature Adipocytes in 3D Collagen Microfibers Tissues............................................................736F. Louis, S. Kitano, S. Irie, M. Matsusaki

Elastic Bending and Stretching Contributions in the Mechanics of 3D Fibrillar Collagen-based Networks Determine Cancer Cell Phenotype................................................................................................................................................................737

J. Sapudom, L. Kalbitzer, R. Chin, S. Martin, T. Pompe

Evaluating Elastic Matrix Regenerative Potential of MSC-derived Smooth Muscle Cells in a 3-D Elastin-Deficient Tissue Milieu ...................................................................................................................................................................................................738

S. Dahal, A. Ramamurthi

Assembly of PEG Microgels into Porous Cell-Instructive 3D Scaffolds via Thiol-Ene Click Chemistry ............................................739S. Xin, D. Alge

Photoreversible Patterning of Site-Specifically Modified Proteins within Gel Biomaterials.................................................................740J Shadish, C Deforest, G Benuska

Characterizing the Effect of Cell-Matrix Interactions on the Differentiation and Subsequent Vasculogenesis of iPSC-Derived Vascular Progenitor Cells .....................................................................................................................................................741

C Crosby, D Shu, J Zoldan

Biophysical Analysis of the Self-Assembly and Matrix Mechanical Properties of Oligomeric Collagen .............................................742D. Sohutskay, S. Voytik-Harbin

IMMUNE ENGINEERING SIG Novel Pentablock Copolymer Micelle-Based Nanoadjuvants ...................................................................................................................743

S Senapati, D Loh, I Schneider, M Wannemuehler, B Narasimhan, S Mallapragada

Enzyme Retention via Galectin-3 for In Vivo Administration of Therapeutics ......................................................................................744S. Freeman, E. Bracho-Sanchez, S. Farhadi, A. Restuccia, M. Fettis, G. Hudalla, B. Keselowsky

Modulating Immune Responses with Optimized Galectin-1 Therapies...................................................................................................745G Hudalla, M Fettis

Tumor Angiogenesis and Lymphangiogenesis Effects on Size-Regulated Profiles of Tumor-derived Molecular Dissemination to Draining Lymph Node-resident Immune Cells .............................................................................................................746

N. Rohner, M. O’Melia, A. Schudel, S. Thomas

DNA Netosis Engineered to Ensnare and Kill Tumor Cells ......................................................................................................................747T Cao, M. King

A Melanin-Mediated Cancer Immunotherapy Patch.................................................................................................................................748Y Ye, Z Gu, C. Wang, X. Zhang, Q. Hu, Y. Zhang, Q. Liu, D. Wen, J. Milligan, A. Bellotti, L. Huang, G. Dotti

Fc-functionalized Microparticles to Modulate the Physical Extent of Complement Activity ...............................................................749T Sulchek, B. Holt

Isolation of Antigen-Specific Plasma Cells using Janus Particles .............................................................................................................750K. Ramirez, T. Sulchek

Cryogel-supported ex vivo Engineering of the Tumor Microenvironment in 3D ...................................................................................751S Bencherif, T Colombani, M Rezaeeyazdi

TRAIL-Conjugated Liposomes to Kill Chemoresistant Cancer Cells in the Lymph Nodes..................................................................752J Greenlee, Z Zhang, F Yu, D Liu, M King

Proteome Analysis of Human Monocyte and Monocyte-Derived Macrophage Secretions Post Exposure to Biomaterials: Generation of Immuno-modulatory Molecules...................................................................................................................753

S. Shrestha, M. McFadden, A. Gramolini, P. Santerre

Effect of PEG-4MAL Hydrogel Encapsulation Parameters on Dendritic Cells......................................................................................754N. Beskid, A. García, J. Babensee

A ‘Smart’ Reporter System for the Study of Particulate Vomocytosis ....................................................................................................755N Pacifici, A Bolandparvaz, R Stilhano, E Silva, J Lewis

Synthetic Nanoparticle Antibodies Targeting Myeloid Derived Suppressor Cell for Cancer Treatment............................................756K Roy, R Toy, P Pradhan, J Liu

IMPLANTABLE BIOELECTRONICS Advancing Mesh Electronics Designs for Stable Early through Long-Term Chronic Neural Circuit Interrogation.........................757

R Viveros, T Fu, G Hong, T Zhou, C Lieber

Evaluation of Iridium Oxide – Silicone Composite Electrode Coatings for Neural Stimulation ..........................................................758X Kang, G Schiavone, N Vachicouras, F Fallegger, S Lacour

Characterization and Application of Quantum Dots for Organic Light-Emitting Diodes (OLED) .....................................................759A Frank-Kamenetskii, D Gil, E Brophy, G McNamara, M Newell, B Scammon, J Smiddy, A Thomas, V Reukov

Soft, Hydrogel-Based Electrodes with Conductive and Compressible Attributes for Use in Neuroprosthetics..................................760R Ghatee, A Tolouei, J Fijalkowski, W Besio, S Kennedy

Three-dimensional Mapping of ‘Neuron-Like’ Mesh Electronics/Brain Interfaces ...............................................................................761X. Yang, T. Zhou, G. Hong, T. Fu, T. Zwang, C. Lieber

Microfabrication and in vitro Assessment of Tissue-Engineered Electronic Neural Interfaces (TEENI) ...........................................762C Kuliasha, J Graham, S Mobini, B Spearman, E Atkinson, E Nunamaker, K Otto, C Schmidt, J Judy

Gold Nanoparticle Wires Exhibit Greater Flexibility and Conductivity than Polymer Wires for Bioelectrodes ...............................763S Thourson, A Finlay, C Landry, C Forest

Neural Electrode with Artificial Conduit for Chronic Signal Recording ................................................................................................764W Jung, S Jung, O Kim, H Park, W Choi, D Son, J Kim

INTELLIGENT HYDROGELS FOR BIOMEDICAL APPLICATIONS Hyperbaric Oxygen-Generating Hydrogels for Tissue Regenerative Medicine ......................................................................................765

S Park, K Park

Development of Size-controlled Extracellular Matrix Rich Spheroid Fabricating System by Re-assembling Micro-patterned Stem Cell Patches..........................................................................................................................................................................766

H. Byun, E. Kim, S. Kim, H. Shin

Enhanced Therapeutic Efficacy and Performance of Mesenchymal Stem Cell Loaded Injectable Gelatin Hydrogels for the Treatment of Myocardial Infarction in vivo ...................................................................................................................................767

S Ryu, Y Lee, E Park, K Chang, K Park

Injectable Biodegradable Chitosan-Alginate Hydrogels for Gene Delivery ............................................................................................769J Yan, R Chen, H Zhang, J Bryers

Clicking Mesenchymal Stem Cells on Hydrogel Surfaces: Towards Applications in Wound Healing ................................................770A. Battigelli, B. Almeida, A. Shukla

Stimulating Tumor Cell Clusters by an Environmental Stimuli-responsive Self-folding ......................................................................771J Lim, H Kim, S Shin, S Ban, W Jung, J Jeong

Injectable Gelatin Hydrogels with Reactive Oxygen Species-Scavenging Properties for Therapeutic Delivery.................................772P. Le, K. Park

Evaluation of Gellan Hydrogel Microstructure and Drug Release Kinetics ...........................................................................................774S. Shukla, J. Favata, A. Tripathi, S. Shahbazmohamadi, A. Shukla

Biomimetic Self-assembly of Porphyrin-conjugated Polyaspartamide for Molecular Ultrasound Imaging .......................................775Y Cho, S Oh, S Han, N Jung, B Han, J Jeong

Biodegradable, “Clickable” Poly(Glycolic Acid) Macromers for Hydrogel Functionalization.............................................................776J. Guo, Y. Kim, P. Engel, A. Mikos

Biodegradable Injectable Thermo-gelling Polymer Systems with Longer and Controllable Duration Time of Gel State..................................................................................................................................................................................................................777

Y. Ohya, Y. Yoshida, K. Kawahara, K. Takada, T. Nagata, H. Takai, Y. Yoshizaki, A. Kuzuya

Long-lasting and Bioactive Hyaluronic Acidhydroxyapatite Composite Hydrogels for Injectable Dermal Fillers............................778B Kim, J Park, S Jeong, Y Fan, J Baek, J Song, T Choi, H Kim, S Kim

Injectable Hyaluronic Acid Gel Microspheres for Dermal Filler Applications ......................................................................................779Y Seong, S Jeong, E Song, H Kim

A Tunable 3D Agarose-Well for Reconstructed Human Tissue ...............................................................................................................780H Kim, D Min, S Lee, J Lim, H Ryu, J Jeong

Characterization of Blue Light Crosslinked Poly(β-amino ester)s ...........................................................................................................781N Kohrs, D Puleo

Tuning the Toughness of an Alginate Microgel for Cell-Instructed Delivery .........................................................................................782S Oh, H Kim, S Cho, S Shin, J Jeong

Microscale 4D Programed Hydrogel Designed for Biomimetic Intestinal Platform ..............................................................................783S Shin, W Song, Y Kim, J Jeong

Thermoresponsive Hydrogels for ‘Self-cleaning’ Glucose Biosensor Membranes .................................................................................784P Dong, A Means, F Clubb, L Colvin, G Coté, M Grunlan

Tunable Poly((methacrylic acid)-co-acrylamide) Nanoparticles through Inverse Emulsion Polymerization .....................................785J Zhong, J Clegg, E Ander, N Peppas

Spatiotemporally Modifiable Cellulose Derived Hydrogels as Three Dimensional Scaffolds for Explants .........................................786W Gramlich

Thixotropic and Cytocompatible Hydrogels Formed from a Self-Assembling Bis-Urea Low Molecular Weight Gelator ............................................................................................................................................................................................................ N/A

L Rutgeerts, A Soultan, B Toprkahisar, R Subramani, H Ramon, P Moldenaers, W De Borggraeve, J Patterson

Electroconductive Hydrogel: Hyaluronic Acid-Based Hydrogel Decorated with Electroconductive Nanomaterials for Human Neural Stem Cell Engineering...................................................................................................................................................787

J Shin, Y Choi, E Choi, C Song, S Cho

LOCAL DRUG DELIVERY TO CARDIOVASCULAR TARGETS Fabrication and Characterization of Electrospun Anti-Proliferative Yarns for Vascular Suture Applications.................................788

E Beal, J Lee, S Bae, G Korneva, R Brown

Aligned Nanofibrillar Scaffolds for Controlled Delivery of Modified mRNA.........................................................................................789M. Zamani, C. Alcazar, L. Hou, T. Zaitseva, E. Yakubov, M. Paukshto, N. Huang

LOCAL DRUG, PROTEIN, AND GENE DELIVERY FROM IMPLANT SURFACES AND COATINGS Local Delivery of 1,25-dihydroxyvitamin D3 for Endogenous Antimicrobial Peptide Induction .........................................................790

J Xie, J Jiang, H Wang

Nanocomposite of PLGA/TiO2 Nanotube Film for Controllable Drug Delivery.....................................................................................791H Jia, L Kerr

MATERIALS FOR CARDIOVASCULAR DEVICES, AND BLOOD COMPATIBILITY Evaluation of Dextran Polyelectrolyte Complex-coated Stent in a Porcine Coronary Restenosis Model ............................................792

I Bae, M Jeong, K Lim, D Park, J Park

Effect of a Polymer Free Tacrolimus Eluting Stent by Titanium Dioxide Film Deposition in a Porcine Coronary Restenosis Model ............................................................................................................................................................................................793

D Park, I Bae, M Jeong, K Lim, J Shim, S Lee, J Park

Reduced Platelet Adhesion and Activation on Plasma Treated TiO2 Nanotubes ...................................................................................794M Bencina, I Junkar, M Kulkarni, T Lampe, J Kovac, K Mrak Poljšak, S Sodin Šemrl, M Mozetic, M Valant, V Kralj Iglic, A Iglic

NANOMATERIALS SIG Modulation of Schlemm’s Canal Endothelial Cell Stiffness via Latrunculin Loaded Block Copolymer Micelles..............................795

T. Stack, A. Vahabikashi, M. Johnson, E. Scott

The Two Faces of Titanium Dioxide Nanoparticles Bio-Camouflage in 3D Bone Spheroids ................................................................796A Ribeiro, W Souza, S Piperni, R Borojevic, L Rocha, T Shokuhfar, R Klie, J Granjeiro

Bifunctional Peptides Induced Formation of Gold Nanoflowers with Variable Functionality for Combination Therapy............................................................................................................................................................................................................797

L Wang, C Mao

Carbohydrate-modified Nanofibers as Tools to Study Galectin-3 Binding to Multivalent Glycans.....................................................798A Restuccia, S Farhadi, G Hudalla

pH-responsive Charge Conversional Polymer based Gene Delivery Carriers for Cancer Treatment.................................................799K Ryu, M Lee, H Kang, T Kim

Defect-rich Nanoassemblies of Two-dimensional (2D) MoS2 for Biomedical Applications ...................................................................800K. Singh, J. Carrow, M. Jaiswal, A. Gaharwar

Electrospinning Structured Nanofibers Using Particle Suspensions ........................................................................................................801R Patel, E Ewaldz, B Brettmann

Development of a Novel Gelatin Nanoparticle Delivery System ...............................................................................................................802F Pierson, J Cary, A Whittington

Applying Characterization and Regression Modeling to Obtain Consistent Gelatin Nanoparticle Properties ..................................803A Stevenson, D Jankus, M Tarshis, A Whittington

Thermal Stability and Antioxidant Activity of SOD Conjugated with Nanocrystalline Cerium Dioxide............................................804B Skelton, B Ward, M Bredikhin, D Gil, V Ivanov, V Reukov

Zirconium-based Metal-organic Frameworks Mediate RNAi Gene Knockdown and Extend Small Molecule Release Time ...................................................................................................................................................................................................805

M Teplensky, M Fantham, C Poudel, C Hockings, M Lu, P Li, O Farha, G Kaminski Schierle, C Kaminski, D Fairen-Jimenez

Surface Charge Controlled Selective Staining of Nucleoli with Carbon Dots .........................................................................................806Q Li, A Su, Z Zhu, M Su

NEXT-GENERATION BIOMATERIALS FOR ISLET DELIVERY AND IMMUNE ACCEPTANCE FOR DIABETES A Bio-inspired Hybrid Nanosack for Islet Transplantation in the Omentum .........................................................................................807

P Hwang, D Lim, G Alexander, D Shah, J Garcia, A Shalev, W Cui, D Cooper, S Gilbert, H Jun

Local Presentation of the Immunomodulatory Molecule PD-L1 via Synthetic Microgels for Islet Transplantation .........................808M Coronel, J Weaver, M Hunckler, E Yolcu, H Shirwan, A Garcia

Thermoresponsive Antioxidant Hydrogels for Islet Transplantation ......................................................................................................809Y Zhu, X Zhang, X Luo, G Ameer

Re-vascularization of Pancreatic Islets with Selfassembled Endothelial Network .................................................................................810W. Song, A. Chiu, M. Ma

Local Delivery of Immunomodulatory Drugs to Improve the Outcome of Islets Transplantation in Type 1 Diabetes .....................811D Velluto, T De Toni, V Manzoli, A Tomei

Vascular Regenerative Biomaterials for Cell Transplantation Device.....................................................................................................812V Coindre, M Sefton

Development of Polyurethane - Zwitterionic Acrylate Double Network Hydrogels as Membranes for Macro-Device Based Cell Encapsulation ..............................................................................................................................................................................813

A. Garle, Y. Kudva, J. Tonne, Z. Resch, Y. Ikeda, D. Wigle, M. Yaszemski

Multicomponent Polyelectrolyte Microcapsule for Islet Encapsulation: Process, Characterization, in Vivo Performance ....................................................................................................................................................................................................815

D Trelová, L Uhelská, Z Kroneková, V Némethová, A Heydari, L Klešcíková, P Mazancová, F Rázga, V Raus, J McGarrigle, J Oberholzer, A Rokstad, I Lacík

Gellan Gum-Poly-L-Lysine Complexes: A New Biomaterial Platform for Cell Encapsulation ............................................................816S Vieira, E Garet, A Morais, R Reis, Á González-Fernández, J Oliveira

Capillary Alginate Gel (Capgel) for the Delivery and Maintenance of Supportive Mesenchymal Stem Cells ....................................817M. Kwan, A. Bosak, B. Willenberg, N. Giel, N. Echeng

Linkage Groups within Thiol-Ene Photoclickable PEG Hydrogels Affect In Vivo Stability ................................................................818M Hunckler, J Medina, M Coronel, A García

OPHTHALMIC BIOMATERIALS SIG Development of Therapeutic Hydrogels for Traumatic Optic Neuropathy.............................................................................................819

K. Swindle-Reilly, S. Thobe, P. Jiang, A. Soltisz, N. Tram, M. Reilly

Degradation Assessment of Crosslinked CMHA-S Polymer Gel Using Gel Electrophoresis ................................................................820D. Stirland, C. Pompoco, B. Mann

Sustained Release Anti-VEGF by Microparticles for Treating Wet Age-Related Macular Degeneration ..........................................821P Jiang, M Ohr, K Swindle-Reilly

Halloysite Nanotubes as a Potential Chemotactic Agent for Bone Repair...............................................................................................822Y Li, D. Mills

Self-Assembled Peptide Nanorods Embedded in Layer-By-Layer Multilayer Films as Antibacterial Coatings for Hydrogel Contact Lenses ...............................................................................................................................................................................823

R Chang, T Webster

ORTHOPAEDIC BIOMATERIALS SIG Protease Characterization Informs Design of Sustained Release Vehicles for Inhibitors following Rotator Cuff Tear ..................................................................................................................................................................................................................824

E. Trevino, J. McFaline-Figueroa, J. Shah, R. Guldberg, M. Platt, J. Temenoff

The Variations in the Electrochemical kinetics of CoCrMo based Hip Implant: Alloy Microstructure and Orientation ......................................................................................................................................................................................................825

D Bijukumar, S Salunkhe, J Ehrich, S McCarthy, D Hall, H Lundberg, R Pourzal, M Mathew

Understanding Systemic Immune Dysregulation in Severe Trauma and the Effects of Biomaterial-based Interventions ...................................................................................................................................................................................................826

C. Vantucci, L. Krishnan, A. Cheng, K. Roy, R. Guldberg

Generation and Characterization of Wear Debris from Load-Bearing Polymeric Materials ...............................................................827P Turner, P Dean, M McDermott, E Sussman, J Stegemann

Continuous Fabrication of Collagen Fibers Comprised of Uniaxially Aligned Fibrils: The Second Step for Mimicking Hierarchical Collagen Structure of Tendon ............................................................................................................................828

S Yunoki, M Ebisawa, H Hatayama, E Kondo, K Yasuda

Osseointegration of Titanium Implants in a Post-Menopausal Osteoporotic Rat Model Treated with Ibandronate ........................829E Lotz, I Nalic, R Ellis, D Cohen, Z Schwartz, B Boyan

Preliminary Evaluation of Polyethylene Glycol Diacrylate Chitosan for Degradable Antimicrobial Delivery...................................830L. Boles, W. Haggard, J. Jennings

Early Diffusion of Biomimetic Proteoglycans Results in Pericellular Augmentation.............................................................................831E Phillips, B Haislup, J Sincavage, K Prudnikova, M Mulcahey, M Marcolongo

Effect of Covalent Crosslinker Content on Chitosan / Cellulose Nanocrystals Hydrogel Properties ...................................................832S Aliakbarighavimi, A Josselet, E Lungren, Y Sun, T Faulkner, Y Wu, F Pfieffer, C Goldstein, C Wan, B Ulery

Mechanical Properties of Ossedensification Drilling as Compared to Regular Drilling........................................................................833F. Gendy, G. Kurgansky, L. Cavdar, C. Lopez, L. Witek, P. Coelho, A. Torroni

Improved Bone Stability with the Use of Nitinol Implants in Mid-Foot Applications ...........................................................................834L. Actis, D. Petersen, J. Ritz, E. Marcano, D. Castillo, K. Ellington

A Bioengineered Collagen Meniscus Scaffold .............................................................................................................................................835S. Li, N. Lee, H. Chen

Direct Contact Cytotoxicity Evaluation of CoCrFeNi-based High Entropy Alloys................................................................................836R. Newell, I. Arias, A. Mehta, Y. Sohn, S. Florczyk

Investigations of Crystallographic Structure, Antibacterial Efficacy and Bioactivity of Hydroxyapatite Co-Substituted with Selenium and Strontium...................................................................................................................................................837

M. Maqbool, M. Cresswell, P. Jackson, P. Basnett, I. Roy, X. Zhang, A. Boccaccini

Controlled Pore Characteristics and Enhanced Pore Interconnectivity of the Porous Titanium (Ti) Scaffolds by Dynamic Freeze Casting via HF/HNO3 Treatment ....................................................................................................................................838

H Jung, H Lee, H Kim, T Jang

Evaluation of a Composite of Bioglass, Collagen, Anorganic Bone and Autograft in a Rabbit Spinal Fusion Model .......................839H Chen, S Li

3D Bioprintable Conductive Nanoinks for Orthopaedic and Spine Applications...................................................................................840T Shokuhfar

Engineering Optimally Charged Drug Carriers for Targeting Negatively Charged Tissues ................................................................841A Vedadghavami, E Wagner, S Bhakta, S Mehta, D Kim, A Bajpayee

Corrosion Response of Cobalt Chrome – Titanium 6Aluminum 4Vanadium Modular Taper Connections in Revision Constrained Condylar Knee Femoral Constructs ......................................................................................................................842

L Gazza, S Nambu, R Obert

Ultrasound Stimulation of Piezoelectric Composite Harvester with Compliant Layers for Bone Healing .........................................843K Coates, E Friis, E Krech, E Cadel, K Tong, L Lapierre, X Yang

Ascorbic Acid and Calcitriol Effects on Stem Cell Differentiation and Collagen Type on Silk ............................................................844J Pearson, G Gonzalez, K Sanchez, J Ong, T Guda

Evaluation of Cytotoxicity and Wettability Profile of Bacterial Cellulose-Based Materials Associated with Hydroxyapatite and Anti-BMP-2 Antibodies ..............................................................................................................................................845

T. Capote, F. Coelho, M. Cavicchioli, S. Specian, R. Caminaga, A. Medeiros, S. Ribeiro

Improving Stiffness & Strength of Double Network Hydrogels towards Synthetic Cartilage ..............................................................846A. Means, L. Whitney, C. Shrode, M. Grunlan

Evaluation of the Bone Repair Potential of Bacterial Cellulose-Based Materials Associated with Hydroxyapatite and Anti-BMP-2 Antibodies ..........................................................................................................................................................................847

F. Coelho, M. Cavicchioli, S. Specian, R. Caminaga, S. Ribeiro, T. Capote

POLYMERIC DEVICES IN ORTHOPAEDIC APPLICATIONS Polymerization Inhibition of Poly(Methyl Methacrylate) by Rifampin through a Radical Scavenging Mechanism .........................848

G. Funk, K. Cole, E. Horn, K. Kilway, T. McIff

Injectable Body Heat-Activated Tough Biodegradable Nanocomposites for Regeneration ..................................................................849S. Huddleston, H. Kim, C. Duan, G. Ameer

Comparison of Polyvinylidene Fluoride and Polypropylene Barbed Sutures in Patellar Tendon Repair ...........................................850Y. Huang, E. Cadet, J. Cole, M. King

Enhanced Bone Regeneration with Tyrosine-Derived Polycarbonate/Beta-Tricalcium Phosphate Scaffolds in a Critical Size Sheep Tibial Model...................................................................................................................................................................851

X Wu, M Shah Mohammadi, A Pastino, G Pluhar, O Ortiz, A Merolli, J Kohn

In Vitro Wear and Wear Particle Analysis of Conventional Polyethylene Tibial Inserts for Revision Condylar Constrained Knee Systems ............................................................................................................................................................................852

A Shivaram, I Timmerman, S Nambu

Evaluation of Polyvinyl Alcohol Hydrogel Viscoelasticity or Poroelasticity and Resulting Relative Coefficient of Friction.............................................................................................................................................................................................................853

M Vaughn, K Burg, J Corbett

Long-Term Effects of Vitamin E on the Free Radicals and Luminescence Properties of Medical-Grade UHMWPE ......................854S. Gomrok, B. Walters, M. Jahan

Biodegradable Piezoelectric Force Sensor ...................................................................................................................................................855E Curry, T Nguyen

Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity...........................856D Luong, Y Xu, J Walker, D Dean, M Becker

MgO-loading of Poly(glycerol sebacate) to Improve Thermoset Toughness and Mechanical Properties............................................857J Ely, P Gabriele, B Nicholson, J Harris

PROTEIN AND CELLS AT INTERFACES SIG Multi-factor Analysis of Initial Synthetic/Protein Content and Remodeling in Engineered Constructs with Raman Spectroscopy....................................................................................................................................................................................................858

A Theus, K Kerney, J Spano, M Fenn, C Bashur

Investigation of Covalently Tethered Interferon-γ Receptor-Ligand Signaling .....................................................................................859T. Ham, S. Christie, A. Smith, N. Leipzig

Involvement of HMGB1/CD14/MyD88 Axis in the Inflammatory Immune and Healing Response to a Bone Extracellular/Acellular Matrix Collagen Membrane .................................................................................................................................860

E. Silveira, A. Araujo-Pires, C. Biguetti, A. Fonseca, G. Assis, A. Garlet, G. Garlet

Cell Responses on Polyelectrolyte-grafted PEEK Substrates Prepared by a Self-Initiated Photoinduced Polymerization ................................................................................................................................................................................................861

Y Inoue, K Fukazawa, S Yanokuchi, K Ishihara

Effect of Integrin Alpha V Silencing on Osteoblastic Differentiation Induced by Titanium with Nanotopography ..........................863M Beloti, H Lopes, G Freitas, P Oliveira, A Rosa

Elucidating Independent and Combinatorial Effects of Gel Diameter and Hydrophobicity on Protein Adsorption.........................864J Clegg, J Gu, J Sun, M Roy, A Venkataraman, N Peppas

RACING FOR THE SURFACE: RECENT DEVELOPMENT IN ANTIMICROBIAL AND OSTEOINDUCTIVE BIOMATERIALS Innovative Treatments of Intra- and Extra-Cellular Bacteria using Silver Nanoparticles....................................................................865

B. Li, J. Kang, K. Hughes

Hydrogel Delivery of Lysostaphin Eliminates Orthopaedic Hardware Infection by Staphylococcus aureus and Supports Fracture Healing ............................................................................................................................................................................866

C Johnson, J Wroe, R Agarwal, K Martin, R Guldberg, R Donlan, L Westblade, A García

Inhibition of Bacterial Adhesion on Nano-Textured Stainless Steel 316L by Electrochemical Etching ..............................................867Y Jang, W Choi, C Johnson, A García, P Singh, V Breedveld, D Hess, J Champion

Collagen-Elastin-like Polypeptide-Bioglass Composite Scaffolds for Bone Tissue Engineering ...........................................................868B. Gurumurthy, P. Pal, A. Janorkar

Antibacterial Tri-Magnesium Phosphate Pentahydrate Coatings on polyetheretherketone (PEEK) Implants by Rapid Microwave Irradiation Technique ....................................................................................................................................................869

P. Sikder, S. Bhaduri

Multifunctional Titanium Oxide Nanotubular Structures for Osseointegrated Implants .....................................................................870L Rocha, S Alves, S Patel, A Rossi, A Ribeiro, C Sukotjo, M Mathew, P Lisboa Filho, J Celis, T Shokuhfar

SMART HYDROGELS FOR CARDIOVASCULAR THERAPY The 3D Functional Biomechanical Impact of Injecting Dual-crosslinking Hydrogels into Myocardium ............................................871

D Li, R Avaz, C Rodell, J Burdick, J Gorman, R Gorman, M Sacks

A Polyester Based Hydrogel as Medical Material with Degradable and Photoluminescent Properties...............................................872Y Tsou, X Xu

Targeted Three-Layered Micelles and Injectable Hydrogels for Systemic and Local Gene Delivery Systems ...................................873T Fujiwara, O Merkel, D. Abebe, R. Kandil, M. Mohammad, Y. Li

Chitosan-collagen Thermosensitive Hydrogels with Tunable Mechanical Properties for Cell Therapy .............................................874E Hui, S Lerouge

SUPRAMOLECULAR DESIGN OF NETWORK BIOMATERIALS Cross-linked Cellulose Nanofibril (CNF) Hydrogels via Thiol-ene Click Reaction as Extracellular Matrix Mimics.........................875

N Dadoo, W Gramlich

The Impact of Inverse Double Networks on Swelling Behavior and Drug Release in Polyvinyl Alcohol- Poly Acrylic Acid Hydrogels................................................................................................................................................................................................876

T. Guda, S. Miar

A Computational and Experimental Approach for Designing Co-Assembling Peptides As Recombinant Fusion Tags ..................................................................................................................................................................................................................877

D. Seroski, Q. Shao, K. Wong, A. Paravastu, C. Hall, G. Hudalla

Spatial Guidance of Microstructured Colloidal Aggregates Controls Endothelial Cells Behavior ......................................................879Y. Yuan, D. Sarkar

Fibroblast Proliferation Enhanced by Hydrogel Substrate Made from Charge Attraction of Recombinant Spider Silk Protein and Natural Polysaccharides ...................................................................................................................................................880

C Peng, E Drennon, K Hafner, D Dean, W Marcotte Jr.

SUPRAMOLECULAR NANOMATERIALS FOR DRUG DELIVERY, IMAGING, AND IMMUNOENGINEERING Multifactorial Design of Modular Peptide Nanofiber Active Immunotherapy to Overcome Self-Tolerance......................................881

L. Shores, J. Collier

Tunable Self-assembly of Resilin-Like/Elastin-Like Block Copolypeptides As Sequence-defined Drug Delivery Carriers............................................................................................................................................................................................................882

S. Xiong, M. Dzuricky, I. Weitzhandler, A. Chilkoti

Near Infrared Dye-Conjugated Oxidative Stress Amplifying Polymer Micelles for Dual Imaging and Synergistic Anticancer Phototherapy...............................................................................................................................................................................883

D Lee, J. Noh, E. Jung, S. Hong, S. Sun, H. Kim

Temperature-Responsive Particles from Self-Assembly of Polysaccharides and Elastin-Like Polypeptide Mixtures .......................884J Tang, S Caliari, K Lampe

An α-helical Peptide Nanofibers Vaccine for Anti-Tumor Humoral Response ......................................................................................885Y Wu, J Collier

Therapeutic and Diagnostic Applications of HDLMimetic Nanoparticles Engineered in Microfluidics .............................................886Y. Sei, J. Ahn, E. Shin, A. Santiago-Lopez, N. Jeon, Y. Jang, Y. Kim

Janus Gold Nanoplates: Dual Coated Amphiphilic Gold Nanoplates for Supramolecular Assembly .................................................887E Chowdhury, R Keynton, M O’Toole

Self-assembly Polymer-protein Nanogels Modulate Immune Response through Polymer-mediated Adjuvant Effects...............................................................................................................................................................................................................888

M Mosquera, T Jing, S Kim, A Singh

Drug Release Mechanisms from Nanospheres Investigated using Quartz Crystal Microbalance ........................................................889A Patel, M Lima, S Murthy, J Kohn

In Vitro Cellular Interactions of Multimodal Cellulose Nanocrystal and Lignin Nanoparticles for Drug Delivery Applications.....................................................................................................................................................................................................890

S. Imlimthan, A. Correia, V. Balasubramanian, P. Figueiredo, K. Lintinen, A. Airaksinen, M. Kostiainen, H. Santos, M. Sarparanta

Thixotropic Hydrogels of PEGylated Dendrimer and Alpha-Cyclodextrin for Gene and Drug Delivery ...........................................891G Williamson, J Wang, H Yang

Novel Nanoparticle Capable of Imaging Stem Cell Viability ....................................................................................................................892K Dhada, L Suggs

Fabrication of Blue-Fluorescent Nanodiamonds Conjugated with Alkyl Isocyanate for Cellular Bioimaging...................................893R Kang, S. Choi

Synthetic High-density Lipoprotein Nanodiscs for Personalized Vaccination Against Glioblastoma Multiforme.............................894A Schwendeman, J Moon, L Scheetz, X Sun

Phase Change Material Nanospheres with Nanodiamonds and Chlorin e6 for Photodynamic and Photothermal Tumor Therapy ..............................................................................................................................................................................................895

S. Baek, S. Choi

Polymeric Micelles for Controlled Delivery of Hydrogen Sulfide.............................................................................................................896U Hasegawa, A Van Der Vlies, I Nakase, T Takatani-Nakase

SURFACE CHARACTERIZATION AND MODIFICATION SIG Fast Imaging and Nanomechanical Charaterization of Cells and Biomaterials by Atomic Force Microscopy ..................................897

S Kaemmer, M Thompson, T Mueller

Copper Nanoparticles Assisted Nitric Oxide Releasing Antithrombic and Antibacterial Biomaterial................................................898J Pant, M Goudie, S Hopkins, E Brisbois, H Handa

Biodegradable Chitosan/Tannic Acid Polyelectrolyte Coatings with Antibacterial Activity ................................................................899M Kumorek, I Minisy, M Voršiláková, D Kubies

Photoreactive Surface Coating on the Implantable Porous Biomaterials using a Block-Type 2-Methacryloyloxyethyl Phosphorylcholine (MPC) Polymer .......................................................................................................................900

S Chen, K Fukazawa, Y Inoue, K Ishihara

Functionalization of Titanium Surfaces in a Protein Rich Medium .........................................................................................................901S Rao, M Mathew, C Takoudis, F Silva, S Hashemiastaneh, J Souza

Super-Reactive Bromoester Surface Initiator for ATRP Prepared by Glow-Discharge RF Plasma ...................................................902M Mecwan, B Ratner

Osteoblast Viability and Differentiation on Calcium Soaked Titanium Oxides .....................................................................................903P. Pal, H. Johnson, J. Nelson, A. Janorkar, R. Williamson, M. Roach

Prevention of Occlusion and Cell Adhesion in 3D-Printed, Liquid-Infused Tympanostomy Tubes ....................................................904M Le, N Black, I Pavlichenko, E Kozin, A Remenschneider, J Aizenberg, J Lewis

Fast Calcium Phosphate Deposition on Polyetheretherketone through Simple Chemistry...................................................................905A. Wen, H. Wen, Y. Kang

Anodic Growth of Microporous Oxide on Ti6Al4V Using a Fluoride Free Electrolyte .........................................................................907B. Ercan, M. Izmir

QAC-Dendrimer and Chitosan Antimicrobial Finishing of Hernia Mesh...............................................................................................908J Wang, A Brown, W Krause, M King

Quantification of Hydroxyl Ion Concentration in Hydroxyapatite ..........................................................................................................909L Pluduma, K Gross, C Rey

Polymer Brush Modified Capillary Microfluidics for Efficient Capture of Circulating Tumor Cells .................................................910Y Zheng, J. Xia, M. Su

Surface Modification of Electrospun Polymer Tubular Conduits using Low Temperature Reduced Pressure Plasma ..............................................................................................................................................................................................................911

B Tucker, P Baker, Y Vohra, V Thomas

THEREPEUTIC STRATEGIES FOR THE TREATMENT OF INFECTIOUS DISEASES In Vitro Testing of a First-in-class Antibiotic used in an Anti-biofilm Coating ......................................................................................912

N Ashton, G Allyn, R Epperson, T Haussener, H Reddy, R Looper, D Williams

Peptide-Enriched Nanocarriers for the Growth Inhibition of Antibiotic-Resistant Bacteria ...............................................................913N Bassous, T Webster

Broad Spectrum Antibiotic Self-Assembling Peptides ............................................................................................................................... 914B. Sarkar, S. Jaisinghani, P. Nguyen, V. Kumar

Evaluation of the Antimicrobial and Potentiation Activity of Cationic Polyrotaxanes Against Escherichia Coli ..............................915J Qiao, Z Liu, M Xiong

TISSUE ENGINEERING SIG Growth Factor-encapsulated and Cell-laden Nanofibrous Bilayer Scaffolds for Vascular Regeneration ...........................................916

Y Zhou, H Sun, M Wang

3D Alginate Hydrogel Matrix for Cell Encapsulation and Long-Term Preservation ............................................................................917S. Khanal, S. Tatum, E. Johnson, N. Bhattarai

Bijels-derived Hybrid Hydrogel Membranes and Growth Factor Delivery ............................................................................................918H Sun, J Li, M Wang

Biphasic Calcium Phosphate Bioceramics for Facial Recontour: in vitro, in vivo and Clinical Outcomes .........................................919S. Lobo, O. Moreira Filho, F. Wykrota

Immunoisolating poly(ethylene glycol) Based Capsules Support Ovarian Tissue Survival to Restore Endocrine Function ...........................................................................................................................................................................................................920

J Day, A David, A Cichon, T Kulkarni, M Cascalho, A. Shikanov

Effect of Raspberry Ketone-Loaded Chitosan Membranes on Saos-2 Cell Growth ..............................................................................921P. Cameron, H. Su, V. Murali, F. Delbuque Guerra, J. Bumgardner

Evaluation of Heparin-Collagen Layer-by-Layer films as Nerve Growth Factor Reservoirs...............................................................922L Pinzon, A Mulero, J Almodovar

Biological Differences of Human Mesenchymal Cells Derived from Different Bone Tissues and Comprehensive Gene Expression Analysis..............................................................................................................................................................................923

Y. Yamazaki, Y. Sugimoto, K. Moriyama, K. Baba, Y. Sone, T. Sugimoto, T. Iwata, S. Onizuka, A. Takeda

Histological Evaluations of the Effects of Diabetes on Renal Vasculature ..............................................................................................924D Pollard, A. Simionescu

TRANSLATION OF NANOPARTICLE CONTRAST AGENTS FOR CLINICAL X-RAY IMAGING MODALITIES Labelling Low Density Lipoprotein with Gold Nanoparticles or Iodine Prevents Uptake in U937 Cells ............................................925

H. Prebble, E. Searle, R. Aamir, N. Anderson, A. Butler, S. Gieseg

Hydrothermal Synthesis and Characterization of Hafnium Oxide Nanoparticles for Biomedical Applications ................................926T. McGinnity, V. Sokolova, O. Prymak, M. Epple, R. Roeder

Radiographic Phantom Mimicking Varying Levels Breast Tissue Density for Translational Investigation of Contrast-Enhanced Detection of Breast Microcalcifications.....................................................................................................................927

T Finamore, L Irimata, E Gies, T Vargo-Gogola, R Roeder

Engineered T-cell Cancer Immunotherapy Tracking with X-Ray Computed Tomography ................................................................928J. Kim, P. Chhour, A. Silva, H. Shin, A. Posey, D. Cormode

Cytocompatibility of Hafnium Oxide Nanoparticle Imaging Probes Prepared Using a Novel Templated Synthesis.........................929P Nallathamby, V Sokolova, O Prymak, M Epple, R Roeder

Development of Spectral Photon-Counting CT Specific Contrast Agents and Ultra-Small Tantalum Oxide Nanoparticles ..................................................................................................................................................................................................930

J. Kim, D. Bar-Ness, S. Si-Mohamed, P. Douek, D. Cormode

Non-Invasive, Longitudinal Measurement of Collagen Scaffold Degradation Using Computed Tomography and Gold Nanoparticles .........................................................................................................................................................................................931

T Finamore, T Curtis, J Tedesco, K Grandfield, R Roeder

Ultrasmall Glutathione-Coated Silver Sulfide Nanoparticles for Breast Cancer Screening with Dual-Energy Mammography or Computed Tomography ................................................................................................................................................932

J. Hsu, K. Lau, E. Cruz, A. Maidment, D. Cormode

Quantification of Mixed Contrast Agents and Material Compositions Using Photon-Counting Spectral CT ....................................933T. Curtis, R. Roeder

Wulff in a Cage Gold Nanoparticles as Contrast Agents for Computed Tomography and Photoacoustic Imaging ..........................934M. Hajfathalian, A. Amirshaghaghi, P. Chhour, P. Naha, J. Hsu, S. Neretina, D. Cormode

Effect of Antibody Density on Immunotargeting and Radiographic Detection of HER2+ Breast Cancer Cells with Au@SiO2 NPs..................................................................................................................................................................................................935

T. McGinnity, T. Vargo-Gogola, R. Roeder

Author Index