ISBN: 978-1-5108-8390-1

Society for Biomaterials Annual Meeting and Exposition 2019

Seattle, Washington, USA 3 - 6 April 2019

Part 1 of 2

The Pinnacle of Biomaterials Innovation and Excellence

Transactions of the 42nd Annual Meeting Volume XL

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TABLE OF CONTENTS

PART 1

NANOMATERIALS FOR THERAPEAUTIC DELIVERY DNA Caged-Micelle Erasable Labels for Multiplexed Immunohistochemistry.......................................................................................... 1

J. Winter, E. Jergens, Y. Cui

Genetically Encoded Photocleavable Linkers for Protein Release from Biomaterials ............................................................................... 2J. Shadish, A. Strange, C. Deforest

Using Click Chemistry to Target and Refill Drug-Eluting Depots ............................................................................................................... 3Y. Brudno

Designer Excipients Enable Oral Delivery of Poorly Soluble Drugs ............................................................................................................ 4J. Ting, F. Bates, T. Reineke

IR820-Loaded PLGA Nanoparticles for Photothermal Therapy of Triple-Negative Breast Cancer ....................................................... 5E. Day, D. Valcourt, M. Dang

Effects of Nanometal Incorporation on Platelet-like Particle Properties and Antimicrobial Activity ..................................................... 6E. Chee, S. Nandi, E. Sproul, A. Brown

The Role of Activation in Macrophage Phagocytosis and Exocytosis of Oligonucleotide Nanoformulations ......................................... 7E. Wayne, C. Long, A. Kabanov

ORTHOPEDIC BIOMATERIALS SIG1 Composite Hydrogels and Their Mechanisms to Inhibit Matrix Mineralization by Hypertrophic Chondrocytes................................. 8

J. Chen, A. Donius, J. Taboas

Compliant Interfaces and Fretting Corrosion in Modular Taper Junctions: The Micromechanics of Contact ..................................... 9S. Smith, J. Gilbert

Injectable Sulfonated Methylcellulose Hydrogels for Growth Factor Sequestration and Nucleus Pulposus Repair ........................... 10N. Haq-Siddiqi, K. Bunde, W. Nnadi, J. Iatridis, S. Nicoll

Design Considerations for Piezocomposite Materials for Electrical Stimulation in Orthopedic Implants - Torsion ........................... 11E. Krech, E. Haas, G. Tideman, B. Reinsch, E. Friis

Elastohydrodynamic Lubrication Model in 3D of Polycarbonate Polyurethane Acetabular Cups for Hip Implants.......................... 12A. Ford, S. Ferguson, L. Pruitt, L. Gao

Strontium-Coated Clay Nanoparticles for Bone Regeneration................................................................................................................... 13A. Elumulai, Y. Luo, A. Humayun, D. Mills

FROM BENCH-TO-BEDSIDE: TRANSLATING BIOMATERIALS RESEARCH *BTI* 1 Lab-on-a-Printer™ - 3D Bioprinting Technology Enabling Functional Human Tissues on Demand ................................................... 14

T. Mohamed, C. Dickman, V. Russo, K. Thain, S. Pan, M. K. Khan, E. Käpylä, S. Beyer, S. Wadsworth

Translational Focus Design for New Tissue Adhesive Technologies .......................................................................................................... 15G. Munoz Taboada, N. Artzi

Distribution and Retention of Neurotrophin-3 in Cochlea .......................................................................................................................... 16Q.-Y. Hu, R. Richardson, A. Wise, R. Stewart, J. Lee, F. Shi

Delivery of Bone-Binding Brain-Derived Neurotrophic Factor (BDNF) Analogue Ris-DHF Supports Hearing Recovery After Noise Damage in vivo ............................................................................................................................................................ 17

D. Jung, J. Kempfle, C. Hamadani, K. Nguyen, B. Kashemirov, A. Zhang, C. McKenna

Bioresorbable Poly(glycerol sebacate) Coated Polyglycolide Textile as a Regenerative Carotid Arterial Patch .................................. 18R. Smalley, S. Lu, A. Weber, A. Metzger, J. Harris, P. Gabriele

Bench to Bedside: Quantum Dot Probes for Clinical Flow Cytometry ...................................................................................................... 19J. Winter

CARDIOVASCULAR BIOMATERIALS AND BLOOD COMPATIBILITY Prevention of Acute Venous Stent-induced Thrombosis Using Inhibition of FXII................................................................................... 20

M. Hinds, K. Nguyen, M. Wallisch, J. Johnson, A. Gruber

In vitro Dynamic Thrombogenicity Testing of Biomaterials: Impact of Test Sample Length and Flow Loop Configuration .................................................................................................................................................................................................... 21

M. Jamiolkowski, M. Golding, R. Malinauskas, Q. Lu

Inorganic Polymerization for Crosslinking Porcine Pericardium as Bioprosthetic Heart Valves with Improved Extracellular Matrix Stability and Biocompatibility.................................................................................................................................... 22

G. Guo, L. Jin, W. Jin, Y. Lei, Y. Wang

Correlating Thrombus Constituents of Surface-Modified Vascular Graft Materials to Luminal Volume Using MicroCT to Better Quantify Clinical Functionality ..................................................................................................................................... 23

D. Anderson, A. Gupta, M. Hinds

Enhanced Biocompatibility of Stents via CD47 Surface Functionalization ............................................................................................... 24V. Inamdar, E. Fitzpatrick, I. Alferiev, C. Nagaswami, R. Levy, I. Fishbein, S. Stachelek

Biodegradable, Elastic Polyurethane with Enhanced Anti-Thrombogenicity as Blood-Contacting Biomaterials................................ 25C. Xu, A. E. Kuriakose, D. Truong, P. Punnakitikashem, K. T. Nguyen, Y. Hong

Engineering Ubx-based Materials to Promote and Guide Neovascularization ......................................................................................... 26G. Geraldo Mendes, D. Howell, S.-P. Tsai, K. Bayless, S. Bondos

Sustained Release of Synthetic Glycopolymers for Enhanced Endothelialization of Electrospun Scaffolds ......................................... 27S. Jiang, J. Wu, Y. Hang, Q. Liu, D. Li, H. Chen

ENGINEERED BIOMATERIALS FOR NEURAL APPLICATIONS 1 Nanoparticle Delivery Precision Based on Sex-dependent Opening of the Blood-brain Barrier after Brain Injury............................ 28

V. Bharadwaj, C. Copeland, T. Anderson, J. Lifshitz, V. Kodibagkar, S. Stabenfeldt

Transplantation of V2a Interneurons and Neural Progenitors after Cervical Spinal Cord Injury........................................................ 29S. Sakiyama-Elbert, R. Thompson, L. Zholudeva, M. Lane

Rapidly Assembling Pentapeptides for Injectable Delivery (RAPID) Hydrogels as Cytocompatible Cell Carriers ............................ 30J. Tang, K. Lampe

An Anti-Inflammatory Nanoscaffold for Enhanced Stem Cell Transplantation and Neuronal Differentiation Post-Spinal Cord Injury ........................................................................................................................................................................................... 31

L. Yang, S. Cerqueira, J. Lee, K.-B. Lee

3D Graphene Oxide Scaffolds as Pro-Regenerative Biomaterials in the Rat Injured Spinal Cord ........................................................ 32M. Serrano, A. Domínguez-Bajo, A. González-Mayorga, E. López-Dolado

Particle Hydrogels Lead to Decrease in Gliosis and Promote Axon and Vessel Formation After Stroke.............................................. 33E. Sideris, S. Carmichael, T. Segura

3D PRINTING AND BIOENGINEERED TISSUES FOR IN VITRO DISEASE MODELING AND PULMONARY APPLICATIONS 3D Printing of Cell Spheroids Within Self-healing Hydrogels .................................................................................................................... 34

A. Daly, M. Davidson, K. H. Song, J. Burdick

An Osteocyte 3D Culture System to Study Osteochondral Strains and Fluid Flow in an ex vivo Model .............................................. 35R. Wilmoth, A. Aziz, A. Uzcategui, V. Ferguson, S. Bryant

Multiscale Modeling of Vascular Pathophysiology Using 3D Bioprinting ................................................................................................. 36K. Gold, A. Gaharwar, A. Jain, R. Dedas, T. Snell, N. Pandian

3D Printing Unmodified Hydrogels Using Rail-Based Open Microfluidics............................................................................................... 37J. Day, U. Lee, A. Haack, W. Lu, A. Theberge, E. Berthier

Engineering an in vitro Model of Ductal Carcinoma In Situ Using FRESH 3D Bioprinting .................................................................. 38J. Tashman, T. Hinton, D. Brown, D. Shiwarski, A. Lee, A. Hudson, A. Lee, A. Feinberg

Lung Extracellular Matrix Hydrogels for Mesenchymal Stem Cells 3D Bioprinting .............................................................................. 39J. Otero, B. Falcones, E. Marhuenda, I. Almendros, D. Navajas, R. Farre

The Role of ECM Composition in Bioengineered Lung Barrier Formation ............................................................................................. 40R. Heise, B. Young, K. Shankar, R. Pouliot, D. Weiss

Bottom-up Strategies for Engineering Distal Lung Structure in vitro ....................................................................................................... 41N. Darling, T. D'Ovidio, C. Magin

BIOMATERIALS FOR THERAPEUTIC DRUG DELIVERY RAPID FIRE Nanoengineered DNA-based Injectable Hydrogels as Sustained Drug Delivery Platform for Cranial Defect Repair......................... 42

S. Basu, S. Pacelli, A. Paul, Y. Feng, Q. Lu, J. Wang

Design of Biocompatible Crosslinkers for Tuning Hydrolytic Degradation of Polyethylene Glycol Hydrogels ................................... 43S. Kroger, L. Hill, S. Zustiak

Biosensitive Hydrogel Depot with Rapid and Long-Term Drug Delivery Efficacy .................................................................................. 44P. Dosta Pons, N. Artzi, E. Zhang, J. Conde

Controlled Release of Anti-inflammatory and Pro-angiogenetic Agents via Microbeads Scaffolds....................................................... 45J. Liang, K. Jiang, R. Accolla, C. Stabler

Dual Release of Anti-Inflammatory and Anti-Microbial Drugs from Affinity Polymer Coated Sutures .............................................. 46R. Haley, V. Qian, G. Learn, H. Von Recum

Cellular Effects of Carbon Monoxide Releasing Poly(diol-citrate) Polymers ........................................................................................... 47A. Webb, D. Lichlyter, B. James

In Situ Integration of Electrospun Fibers with Microneedles ..................................................................................................................... 48R. Creighton, J. Phan, K. Woodrow

Design of an Affinity Based Cytokine Release System to Temporally Control Macrophage Behavior.................................................. 49E. Lurier, A. Smits, C. Bouten, K. Spiller

Mitigate Hydrophobicity-Induced Immunogenicity using Biocompatible Sugar Poly(orthoester) ........................................................ 50W. Du, S. Maiti, S. Manna, J. Shen, A. Esser-Kahn

Single Application Thixotropic Antibiotic Delivery Systems for Otitis Externa....................................................................................... 51M. Serban, B. Serban, J. Alverson, N. Priestley, E. Arrigali

Parallel Evaluation of Two Promising Immunoisolation Strategies for Beta Cell Replacement: Conformal Coating Versus Double Alginate Encapsulation .......................................................................................................................................................... 52

T. De Toni, A. Stock, S. Safley, C. Weber, O. Alcazar, P. Buchwald, A. Tomei

Islet-like Microtissues with Toroidal Geometry for Enhanced Cellular Viability .................................................................................... 53Y. Chen, D. Nguyen, Y. X. Wong, T. Dang

Thermosensitive Magnetic Liposomes for Dual Targeted Stimuli-Responsive Drug Delivery in Glioma Treatment.......................... 54J.-P. Chen, H.-L. Hsu, Y.-J. Lu

Controlled Cell Migration Within Cell Selective Hydrogels ....................................................................................................................... 55E. Pashuck, S. Fung, N. Joshi, J. Kohn

Local Delivery of Epigenetically Stimulating Folic Acid For Peripheral Nerve Regeneration ............................................................... 56J. Yang, G. Kim

NANOMATERIALS / DRUG DELIVERY RAPID FIRE Preparation of Injectable Thermogelling Nanoparticles for Chemokine Release and Cancer Cell Entrapment ................................. 57

M. K. Khang, A. Hakamivala, J. Zhou, Y. Huang, L. Tang

Development of a Nanomaterial-based Localized Immunomodulatory and Anti-inflammatory (LISAI) Regimen to Improve Pancreatic Islets Transplantation .................................................................................................................................................. 58

D. Velluto, T. De Toni, A. Tomei

H2O2-activatable Nanoparticles for Contrast-enhanced Photoacoustic Imaging and Therapy of Thrombosed Vessels ................................................................................................................................................................................................................ 59

D. Lee, E. Jung, L. Jeong

VCAM-1 Targeted Poly(β-Amino Ester) Nanoparticles for Gene Delivery Under Flow and to the Endothelium ............................... 60N. Distasio, S. Lehoux, M. Tabrizian

Injectable Dynamic Covalent Hydrogels of Boronic Acid Polymers Cross-Linked by Bioactive Plant-Derived Polyphenols........................................................................................................................................................................................................ 61

P. Delparastan, Z. Huang, P. Burch, J. Cheng, Y. Cao, P. Messersmith

A Predictive Analytics Approach for Rational Design of Nanomedicines with Programmable Drug Release...................................... 62A. Mullis, S. Broderick, A. Binnebose, N. Peroutka-Bigus, B. Bellaire, K. Rajan, B. Narasimhan

Cell Surface Vimentin as a Target for Liposome-based TRAIL Delivery to Metastatic Cancer Cells .................................................. 63M. Lopez Cavestany, Z. Zhang, M. King

Supramolecular Galectin Assemblies Modulate T Cell Function ............................................................................................................... 64M. Fettis, G. Hudalla

High Throughput Identification of Synthetic Polymers with Globular and Protein-Like Features ....................................................... 65R. Upadhya, N. S. Murthy, S. Kosuri, M. Tamasi, A. Gormley

Label-Free, Magnetic Nanocarrier based, Precision Combinatorial Chemotherapeutics Treatment Against Metastatic Cancer for Recurrence-Free Survival......................................................................................................................................... 66

P. Nallathamby, J. Hopf, M. Waters, P. Helquist, V. Jo Davisson

A Polymerization Friendly Dibenzoazacyclooctyne Monomer for Two-Step Bioconjugation ................................................................ 67S. Kosuri, A. Gormley

Fabrication and Characterization of Silk Fibroin Microneedle Meshes for Perivascular Drug Delivery ............................................. 68J. Lee, S. H. Park, E. H. Jang, J.-H. Kim, Y.-N. Youn, W. Ryu

Diffusion-Based Modeling and Drug Delivery of Gasotransmitters from Tissue Engineered Scaffolds ................................................ 69R. Jourdain, S. Rottman, K. Washington, N. Abeyrathna, Y. Liao, C. Bashur

Modular, Click Functionalized Hydrogels for Multilayered Tissue Engineering ..................................................................................... 70J. Guo, Y. S. Kim, V. Xie, J. Lam, P. Engel, A. Mikos

Design of Reductively Responsive Amphiphilic Gel Capsules for Protein Delivery System.................................................................... 71A. Kawamura, H. Nakaura, T. Miyata

DENTAL/CRANIOFACIAL BIOMATERIALS SIG RAPID FIRE Sustained Release of Bone Morphogenetic Protein-2 in Interpenetrating Composite Hydrogels for Promoting Skull Bone Regeneration............................................................................................................................................................................................ 72

S. Kim, J. Kim, B.-J. Kang, K. Kim

Identifying the Reproductive Toxicity of Biocompatible 3D-Printed Dental Resins ................................................................................ 73H. Rogers, E. Zaniker, L. Zhou, A. Kusuhara, F. Duncan, T. Woodruff

Rapidly Curing Chitosan Calcium Phosphate Composites as Dental Pulp Capping Agents .................................................................. 74M. Osmond, J. Newsom, T. Danis, M. Krebs

Integration of Decellularized Ligament and Artificial Material Through Recellularization for Periodontal Reconstruction .................................................................................................................................................................................................. 75

N. Nakamura, H. Harukaze, R. Ohira, M. Yamada, T. Fujisato, T. Kimura, A. Kishida

An Antimicrobial and Osteoinductive Bioadhesive Hydrogel for Treatment of Peri-Implant Diseases ................................................ 76E. Shirzaei Sani, R. Portillo Lara, Z. Aldawood, S. H. Bassir, G. Intini, N. Annabi

Hydroxyapatite (HA) Coating on Zirconia by Sol-gel Method for Dental Implant.................................................................................. 77J. Kim, I. Kang, K.-H. Cheon, S. Park, H.-E. Kim, S.-M. Kim, C.-M. Han

Osteogain™ Enhances the Osteoinductive Potential of Demineralized Bone Matrix .............................................................................. 78M. Harrington, D. Cohen, B. Boyan, Z. Schwartz

Killing of Caries-related Bacteria in vitro and in vivo with Quaternary Ammonium-Bioactive Restorative Materials ............................................................................................................................................................................................................ 79

M. A. Melo, M. Weir, V. Passos, J. Rolim, L. Cheng, C. Lynch, L. Rodrigues, H. Xu

Functionalizing a Dental Sealant with Nano-Amorphous Calcium Phosphate and Dimethylaminohexadecyl Methacrylate for Anticaries Response ........................................................................................................................................................... 80

M. Ibrahim, M. A. Melo, M. Weir, H. Xu

Ectopic and Orthotopic Bone Formation in Rats with Recombinant BMP-9 Incorporated Injectable Microparticles-Gel Composites....................................................................................................................................................................... 81

B. Gaihre, J. Unagolla, C. Jayasuriya

Antibacterial Magnesium Phosphate Micro-Platelets as Next-Generation Healthcare Biomaterials for Surgical Site Infection (SSI) treatment in Orthopedics ...................................................................................................................................................... 82

P. Sikder, S. Bhaduri

Geometric Effects of Open Hollow Hydroxyapatite Microspheres Influence Bone Repair and Regeneration in Sprague Dawley Rats ....................................................................................................................................................................................... 83

Y.-W. Huang, Y. Shen, M. Rahaman, Y. Liu

Horseradish Peroxidase-Catalyzed Hydrogel Accelerates Osteogenic Differentiation of Human Mesenchymal Stem Cells for Bone Regeneration ............................................................................................................................................................................ 84

P. Le, K. M. Park, K. D. Park

Tuning Hierarchal Pore Structure in Emulsion Electrospun Fibers for Estrogen Receptor Agonist Release ...................................... 85P. Johnson, A. Trofinoff, J. Lehtinen, J. Robinson

A Novel Silorane-Based Cement as a Carrier for Rifampin........................................................................................................................ 86G. Funk, E. Horn, K. Kilway, T. McIff

ORTHOPEDIC BIOMATERIALS SIG RAPID FIRE PLGA-Graphene Oxide Matrices for Bone Regenerative Engineering ..................................................................................................... 87

L. Daneshmandi, S. Sydlik, C. Laurencin

Addition of an E8 Domain to Bone Morphogenic Protein 2 Confers Binding to HA Materials to Induce Osteoblastic Signaling ...................................................................................................................................................................................... 88

A. Curry, N. Pensa, A. Barlow, D. McPherson, M. Reddy, S. Bellis

Differential Expression of Non-canonical Wnts During Osteoblast Differentiation on 3-Dimensional Additively Manufactured Constructs................................................................................................................................................................................ 89

M. Berger, K. Bosh, T. Jacobs, B. Boyan, Z. Schwartz

Quantification of Material Loss from the Femoral Taper of Modular Metal-on-Polyethylene Hips Tested in a Hip Simulator ........................................................................................................................................................................................................... 90

R. Bhalekar, S. Smith, D. Langton, T. Joyce

Bioinspired Mineral-Organic Bioresorbable Bone Adhesive ...................................................................................................................... 91A. Kirillova, C. Kelly, N. Von Windheim, K. Gall

Injectable, Statin-Based Body Heat-Activated Tough Biodegradable Nanocomposites for Bone Regeneration .................................. 92S. Huddleston, C. Duan, G. Ameer

Design Considerations for Piezocomposite Materials for Electrical Stimulation in Orthopedic Implants - Compression...................................................................................................................................................................................................... 93

E. Krech, E. Haas, G. Tideman, B. Reinsch, E. Friis

Silk Fibroin-Reinforced Composites for Resorbable Load-Bearing Fixation Devices ............................................................................. 94M. Wei, B. Heimbach

Mechanical Comparison of Double Network Hydrogel Articular Cartilage Substitutes and Natural Knee Joint Cartilage ............................................................................................................................................................................................................ 95

C. Young, M. Vaughn, D. Broughton

In vitro Wear and Metal Ions Release Analysis from Titanium Niobium Nitride Coated Total Knee Arthroplasty Implants ............................................................................................................................................................................................................. 96

A. Shivaram, E. Baker, G. Hines, S. Nambu

Nanofibrous Scaffolds Produced by Electrospinning, Rotary-Jet Spinning and Airbrush for Orthopedic Tissue Regeneration ..................................................................................................................................................................................................... 97

P. Ghannadian, J. Moxley Jr., T. Webster

Fabrication and Multiscale Structure of Silver-doped Bioactive Glass-Ceramic Scaffolds .................................................................... 98A. Marsh, N. Mellott, N. Pajares Chamorro, X. Chatzistavrou

Development of an in vivo Model for Polymethylmethacrylate Leakage During Vertebroplasty and Kyphoplasty............................ 99S. Boorman, Z. Zawacki, J. Slack, J. Engiles, T. Schaer

Spatially Organized 3D-Printed Scaffolds for Osteochondral Interface Regeneration..........................................................................100L. Chow, P. Camacho, A. Behre, K. Seims, H. Busari, P. Schwarzenberg, W. De Long, H. Dailey

Dynamic in vitro Stimulation and Vitamins to Promote Enthesis Regeneration ....................................................................................101J. Pearson, G. Gonzalez, K. Sanchez, J. Ong, T. Guda

IMMUNOMODULATORY BIOMATERIALS RAPID FIRE Immunomodulatory ECM-like Nanofibrous Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus .....................102

X. Liu, Z. Hu

Injectable Inflammation-Responsive Hydrogels Attenuate Symptoms of Load-Induced Osteoarthritis.............................................103T. Wheeler, D. Holyoak, M. Van Der Meulen, A. Singh

Single Dose, Combination Nanovaccine Provides Protection Against Influenza A Virus in Aged Animals ........................................104S. Senapati, K. Ross, R. Darling, J. Alley, D. Verhoven, M. Wannemuehler, M. Kohut, S. Mallapragada, B. Narasimhan

A Hydrogel Platform for Sustained Vaccine Exposure Enhances Humoral Immunity .........................................................................105G. Agmon, E. Gale, E. Axpe, A. Yu, E. Appel

Pathogen-like Particles with Combination Adjuvants Induce Synergistic or Broadened Immune Responses ...................................106R. Toy, P. Pradhan, M. Keenum, N. Jhita, E. Blanchard, N. Narang, M. Suthar, P. Santangelo, D. Shayakhmetov, K. Roy

Attenuating Multiple Sclerosis in Mice with an Antigen-Specific Vaccine ..............................................................................................107A. Kwiatkowski, J. Stewart, J. Cho, T. Drashansky, E. Helm, A. Zuniga, D. Avram, B. Keselowsky

An Antigen-specific Microparticle System Ameliorates Autoimmunity in Mouse Models of Type 1 Diabetes and Multiple Sclerosis............................................................................................................................................................................................108

J. Stewart, J. Lewis, A. Kwiatkowski, J. Cho, T. Drashansky, M. Clare-Salzler, C. Wasserfall, M. Atkinson, D. Avram, B. Keselowsky

Immunomodulation via Lentiviral Delivery from Microporous Scaffolds Alters Metastatic Tumor Cell Recruitment in vivo ........................................................................................................................................................................................109

G. Bushnell, S. Rao, R. Hartfield, Y. Zhang, R. Oakes, J. Jeruss, L. Shea

The Addition of the Amniotic Membrane to Mineralized Collagen Scaffolds for Immunomodulatory Bone Regeneration ...................................................................................................................................................................................................110

M. Dewey, E. Johnson, S. Slater, B. Harley

Near-Infrared-Irradiation-Induced Transformation of Surface Topography for Sequential Modulation of Macrophage Phenotypes to Match Tissue Healing Process .......................................................................................................................111

X. Zheng, L. Xin, Y. Luo, H. Yang, L. Ma, C. Gao

Modular Complement Assemblies as Defined Active Immunotherapies .................................................................................................112K. Hainline, M. Madhira, Z. Bernstein, Y. Wen, J. Collier

Immunomodulatory Stem Cells to Alleviate the Foreign Body Response Against Implanted Biomaterials .......................................113R. Mohammadi, G. Kim, R. Cao, S. Rodriguez, D. Tolsma, J. Lakey

Controlled Release of M2-derived Macrophage Signals to Investigate Role in Foreign Body Response .............................................114C. Witherel, K. Sao, B. Han, L. Han, R. Petrie, K. Spiller

Immunotheranostic Nanomaterials for Monitoring Immunotherapy Response.....................................................................................115A. Kulkarni, A. Nguyen, A. Ramesh

Versatile Assembly of Polymeric Bicontinuous Nanospheres via Flash Nanoprecipitation ..................................................................116S. Bobbala, S. Allen, N. Karabin, E. Scott

ENGINEERED MICROENVIRONMENTS IN HEALTH AND DISEASE RAPID FIRE Directing the Secretory Phenotype of Human Mesenchymal Stem Cells in Porous Assembled Microgel Networks .........................117

A. Caldwell, V. Rao, K. Anseth

Micromolded Gelatin Hydrogels Crosslinked with Laminin for Disease on a Chip Applications ........................................................118R. Besser, R. Maciel, M. Dvornik, D. Carbonero, I. Claure, E. Jones, J. Reda, M. Saporta, A. Agarwal

In vitro Model to Mimic Aggrecan Fragmentation Profiles After Spinal Cord Injury..........................................................................119M. McCrary, Y. H. Song, S. Porvasnik, R. Wachs, A. Fosang, C. Schmidt

The Role of Osteopontin and Sex-Specific Differences in Valvular Interstitial Cells and Their Response to Biochemical Cues ............................................................................................................................................................................................120

M. Schroeder, A. Gonzalez Rodriguez, K. Anseth

Using MicroRNA-122 Mimics or MicroRNA-451 Inhibitors to Prevent the Osteoarthritis Process....................................................121K. Scott, M. Hays, D. J. Cohen, Z. Schwartz, B. Boyan

Mesenchymal Stem Cell Behaviors on 3D Geometric µ-Cavities..............................................................................................................122R. Subbiah, M. Hunckler, A. García, R. Guldberg

Engineered Immune Neoplasms to Study BCR-TLR Cooperative Signaling .........................................................................................123S. Shah, K. Lee, C. York, A. Singh

Development of an Extracellular Matrix-Enriched Gelatin Sponge for Liver Wound Dressing ..........................................................124B. Wang, W. Li

Titanium with Nanotopography Induces Osteoblast Differentiation through Integrin β3 Signaling Pathway...................................125M. Beloti, H. Lopes, G. Freitas, C. Elias, C. Tye, J. Stein, J. Lian, G. Stein, A. Rosa

In vitro Tridimensional Model of the Blood-Brain Barrier by Capillary Self-Organization ................................................................126A. Figarol, Y. Naka, M. Matsusaki

Anthracene Based Dynamic Hydrogels to Probe Stiffness-Mediated Changes in Cardiac Fibroblasts ...............................................127K. Günay, T. Ceccato, J. Silver, K. Bannister, O. Bednarski, K. Anseth

Characterizing and Modeling the Effects of Extracellular Matrix and Fibroblasts on Vascular Cell Function ................................128E. Olszewski, M. Kirby, M. Regier, R. Wang, K. Stevens, J. Davis

Myofibril Remodeling of Human Stem Cell-Derived Cardiomyocytes Responding to Dynamic Surface Topography .....................129Z. Ma, S. Sun, S. Moore, C. Wang, A. Ash-Shakoor, J. Henderson

Using Scaffolded Neuroblastoma to Model Cell-Driven Hypoxia.............................................................................................................130K. Ornell, E. Newman, J. Coburn

The Effect of MSC Phenotype on Osteogenesis and Vasculogenesis in Engineered Multiphase Microenvironments .......................131N. Schott, R. Annamalai, B. Juliar, J. Stegemann

3D BIOPRINTING APPLICATIONS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE RAPID FIRE Digital Light Projection of Poly(Glycerol Sebacate): Rapid Prototyping of Vascular Grafts Microstructures ..................................132

Y.-L. Wu, R. Wang, A. Yan, C.-Y. Ke, X. Ding, Y. Wang

Bioprinting a Vascularized Multi-Tissue Platform for Organ Modeling in Vitro ..................................................................................133M. Tomov, A. Theus, A. Cetnar, V. Serpooshan

3D Printing of Tissue Scaffolds Using a Novel Biocompatible Photocurable Resin ...............................................................................134N. Chartrain, J. Cartwright, C. Williams, A. Whittington

In Situ Quantification of Local O2 Concentration in 3D Bioprinted Constructs Using Luminescent Nanoparticles .........................135M. Gelinsky, A. Akkineni, E. Trampe, K. Koren, A. Lode, F. Krujatz, M. Kuhl

Sustained Perfusion for Improved Long-Term Viability in Large Bioprinted Constructs ...................................................................136K. Willson, S.-J. Lee, J. Yoo, A. Atala

Bio-3D Printing and Near-Field Electrospinning of Bone-Ligament Tissue Engineering Scaffolds ....................................................137N. Elghazali, M. Rush, E. Garcia, C. Buksa, M. Perez, R. Trujillo, S. Lopez, C. Salas

Long-term Outcomes of 3D-Printed Bioactive Ceramic Scaffolds for Regeneration of the Pediatric Skeleton..................................138M. Wang, R. Rodriguez Colon, G. Kurgansky, L. Witek, A. Torroni, B. Cronstein, R. Flores, P. Coelho

3D-Printed Hyperelastic Bone Scaffolds Accelerate Bone Regeneration in Critical-Sized Calvarial Bone Defects ...........................139Y.-H. Huang, A. Jakus, S. Jordan, Z. Dumanian, K. Parker, L. Zhao, P. Patel, R. Shah

Development and Mechanical Characterization of Composite ß-TCP Bioinks for 3D Printing of Dentin Regeneration Scaffolds...................................................................................................................................................................................140

S. Montelongo, G. Chiou, S. Miar, T. Guda, J. Ong

Living Cell-Only Bioprinting for Regenerative Medicine..........................................................................................................................141Y. B. Lee, O. Jeon, S. J. Lee, H. Jeong, E. Alsberg

Cell-Degradable Thermoplastic Poly(thioketal-urethane) Elastomers for 3D Printing Applications ..................................................142D. Groff, P. Patil, C. Duvall, S. Guelcher

Hybrid Additive-Subtractive Laser Fabrication Platform for Shaping Hydrogels ................................................................................143P. Soman, P. Kunwar, Z. Xiong, Y. Zhu, H. Li, A. Filip, R. Ramos

I-Optimal Designed Experiment to Control the Porosity of 3D Scaffolds in Melt Extrusion Additive Manufacturing.....................144A. Yousefi, K. Wood, B. Smucker

3D Bioprinted Constructs Laden with Iron Oxide Nanoparticles for Diverse Tissue Engineering Applications ...............................145A. Theus, M. Hargita, H. Chen, A. Pourmorteza, S. Satola, V. Serpooshan

Heat-activated Spatial Patterning of Gene Expression in 3D Engineered Tissues .................................................................................146D. Corbett, B. Grigoryan, J. Miller, K. Stevens

BIOMATERIALS FOR REGENERATIVE ENGINEERING RAPID FIRE Biodegradable PCL-PLGA-beta TCP Scaffolds for Bone Tissue Engineering .......................................................................................147

A. Kumar, X. Yu

Human Amniotic Membrane Enhanced Allograft Bone Graft .................................................................................................................148R. Early, H. Aberman, C. Clokie

Sequestration of Biomolecules for Controlled Delivery in Mineralized Collagen Scaffolds ..................................................................149A. Tiffany, B. Harley

LIPUS-Derived Mechanical Stimulation of Alginate Hydrogels for Bone Repair: A Regenerative Engineering Approach .........................................................................................................................................................................................................150

F. Assanah, Y. Khan

Intrafibrillar Mineralized Collagen-Based Scaffolds for Bone Repair ....................................................................................................151L. Yu, M. Wei

Additive Manufacturing of Poly(methyl methacrylate) Space Maintainers for Improved Craniofacial Repair ................................152M. Bedell, A. Melchiorri, A. Mikos

Transcriptome Profiling of the Early Response to a Muscle Regenerative Biomaterial ........................................................................153K. Roberts, J. Kim, J. Wolchok

Controlling Heterogeneities in Crosslinking Towards Improving ECM Connectivity for Cartilage Tissue Engineering .....................................................................................................................................................................................................154

M. Maples, S. Chu, S. Lalitha Sridhar, F. Vernerey, S. Bryant

Degradation Rates of Alginate-Chitosan Polyelectrolyte Complexes Influence the Fate of Repair Tissue in Physeal Injuries.............................................................................................................................................................................................................155

J. Newsom, C. Erickson, F. Fontan, K. Payne, M. Krebs, N. Miller, N. Fletcher, Y. Yu, Z. Feuer

Hyaluronic Acid-based Cryogel Scaffolds for Cartilage Tissue Engineering..........................................................................................156B. Li, K. Navare, S. Mehta, S. Bencherif, A. Bajpayee

Cell Membrane-Derived Hydrogel Scaffolds ..............................................................................................................................................157H. Cheng, Z. FanJ. Deng, P. Li

Growth Factor Sequestering Hyaluronic Acid Hydrogel Promotes Network Formation by Human Vascular Cells ........................158S. Browne, S. Hossainy, K. Healy

Design and Evaluation of a Chitosan-based Dermal Filler ........................................................................................................................159C. Ceccaldi, E. Leroux, A. Guerry

Apoptosis-Mediated Decellularization Approaches for Lung Tissue Engineering .................................................................................160Y. H. Song, D. Visosevic, K. Daramola, S. Porvasnik, M. Maynes, C. Schmidt

Using Collagen Microfibers for the Reconstruction of a Vascularized Adipose Tissue Suitable for Breast Regeneration ...................................................................................................................................................................................................161

F. Louis, S. Kitano, M. Matsusaki

ORTHOPEDIC BIOMATERIALS SIG 2 An in vitro Chondro-Osteo-Vascular Triphasic Model Of The Osteochondral Complex .....................................................................162

R. Gottardi, A. Pirosa, P. Alexander, P. Manner, D. Puppi, F. Chiellini, R. Tuan

Rotator Cuff Enthesis Regeneration via Insulin-like Growth Factor-Mimic Delivery ..........................................................................163A. Prabhath, V. Vernekar, M. Badon, X. Tang, G. Dzidotor, J.-E. Avochinou, E. Weber, S. Kumbar, C. Laurencin

Controlling Fiber Alignment Using Magnetically-Assisted Electrospinning for Interfacial Tissue Repair ........................................164R. Tindell, J. Holloway

Biomimetic Triphasic Scaffolds for Osteotendinous Junction Regeneration ..........................................................................................165R. Sun Han Chang, C.-W. Lee, S. Rogers, B. Harley

Vertical Bone Augmentation Using Carbonate Apatite Bone Substitute.................................................................................................166K. Ishikawa, K. Hayashi, A. Tsuchiya, R. Kishida

Impact of Aging on Bioglass Foam Structure and Properties ...................................................................................................................167C. Charbonneau, P. F. Menci, A. Mari, L. De Nardo, F. Vanier, L.-P. Lefebvre

FROM BENCH-TO-BEDSIDE: TRANSLATING BIOMATERIALS RESEARCH *BTI* 2 Use of Nanomaterials to Develop Next Generation of Medical Devices ...................................................................................................168

M. Phaneuf, S. Pathan, M. Contreras, N. Long, R. Kassab, B. Martino, A. Martin, G. Wong, M. Bide, T. Phaneuf

From Bench-to-Bedside: Licensing and Development of a Mineral-Organic Bone Adhesive for Bone Repair ..................................169M. Brown, G. Kay, D. Cochran, J. Fiorellini, B. Hess

Bringing Restorative Heart Valves Towards Clinical Practice .................................................................................................................170M. Cox

The Impact of Regenerative Therapies in the Clinic with Supporting Evidence from the Lab ............................................................171R. Audet, R. Diller, D. Dominguez, R. Kellar

3D-Painted Biomaterials: Hyperelastic Bone™, 3D-Graphene, Fluffy-X™, Tissue Papers, and More for Tissue Repair, Regeneration, and Biofabrication ...................................................................................................................................................172

A. Jakus

ABC103 from Bench to Bedside: Development of a Drug-Eluting Polymer Implant Which Prevents Post-Surgical Lung Cancer Recurrence...............................................................................................................................................................................173

J. Schwartz

Sprayable Biopolymer Hydrogel for the Prevention of Postoperative Adhesions ..................................................................................174L. Costella, R. Villani, C. Tison

BIOMATERIALS FOR CARDIOVASCULAR REGENERATION Integrating Revascularization Therapy with Cardiac Tissue Engineering for Treating Myocardial Infarction................................175

F. Munarin, R. Kant, C. Rupert, A. Khoo, K. Coulombe

Correction of Heart Defects with a Polyurethane-Reinforced Hydrogel Patch in a Rat Model............................................................176Z.-W. Tao, E. Beck, D. Jarrell, E. Vanderslice, M. Lennon, D. Pool, S. Wu, E. Cosgriff-Hernandez, J. Jacot

A Soluble Extracellular Matrix Hydrogel Therapy for Intravascular Infusion......................................................................................177M. Spang, G. Sandoval, T. Lazerson, C. Luo, K. Osborn, P. Cabrales, F. Contijoch, R. Reeves, A. Demaria, K. Christman

A Bio-Hybrid Cardiac Patch Combining Poly(ester carbonate urethane)urea and Porcine Cardiac Extracellular Matrix Digest Induces Improved Ventricular Remodeling in a Model of Chronic Ischemia................................................................178

L. Silveira Filho, G. Coyan, A. D'Amore, S. Luketich, G. Menallo, A. Adamo, N. Kashiyama, Y. Matsumura, W. Wagner

HiPSC Encapsulation Geometry Impacts Engineered Cardiac Tissue Development and Function ....................................................179M. Ellis, B. Harris, E. Lipke

Adventitial Extracellular Matrix Hydrogel Improves Sprouting of Human Thoracic Aortic Aneurysm-Derived Pericytes...........................................................................................................................................................................................................180

B. Fisher, J. Hill, M. Billaud, T. Richards, T. Gleason, J. Phillippi

NANOMATERIALS SIG Nanofibrous Artificial Tissue Scaffold for Three Dimensional Epithelial Tissue Regeneration ...........................................................181

Y. J. Son, W. Mao, J. Shin, J. Lee, H. S. Yoo

Quantification of Lectin-Exosome Binding Affinity Using Lectin-conjugated Janus Nano particles for Detection of Pancreatic Cancer Exosome ..........................................................................................................................................................................182

U. Park, Y. Choi, J. Choi, K. Kim

Real-Time and Long-Time in vivo Imaging in the Shortwave Infrared Window of Perforator Vessels for More Precise Evaluation of Flap Perfusion ...........................................................................................................................................................183

J. Chen, Y. Li, S. Chen

Dual pH and Oxygen Luminescent Nanosensors for Extracellular Metabolism Monitoring................................................................184C. Yang, T. Pan, M. Chen, Y. Tian

Exosome-Polymer Hybrids ............................................................................................................................................................................185S. Yerneni, S. Lathwal, J. Cuthbert, S. Das, K. Matyjaszewski, P. Campbell

Determining Vaccination Status in the Developing World Using Microneedle-Delivered Fluorescent Microparticles .....................186K. McHugh, L. Jing, S. Severt, M. Cruz, H. S. Jayawardena, C. Perkinson, F. Larusson, S. Rose, R. Langer, A. Jaklenec

Differentially Branched Ester Amine Quadpolymers with Amphiphilic and pH Sensitive Properties for Efficient Nucleic Acid Delivery .....................................................................................................................................................................................187

D. Wilson, Y. Rui, K. Siddiq, D. Routkevitch, J. Green

Development of Polymeric Nanogels for Tear Biomarker Detection .......................................................................................................188M. Wechsler, J. Dang, S. Simmonds, N. Peppas

TARGETED AND STIMULI-RESPONSIVE BIOMATERIALS Protease-triggered Delivery of an Anti-Inflammatory Drug for Modulation of Macrophage Proliferation .......................................189

D. Nguyen, B. Soeranaya, T. Truong, T. Dang

Targeted Delivery of Peptide-based Matrix Metalloproteinase-2 (MMP-2) Inhibitor in Dual Sensitive Nanoparticles with Platelet Membrane Camouflage for Ischemic Limb Treatment .............................................................................190

Y. Dang, N. Gao, H. Niu, Y. Guan, J. Guan

A Novel Matrix for Endometrium Regeneration by the Recruitment and Selective Capture of Endogenous Mesenchymal Stem Cells ...............................................................................................................................................................................191

L. Ma, X. Zheng, X. Wang, L. Xin, C. Gao

Magnetoliposome-Integrated Hydrogels for Delayed and Triggered Deliveries.....................................................................................192S. Z. M. Madani, A. Reisch, E. Hughes, G. Bothun, S. Kennedy

Photo-Crosslinking of Recombinant Protein Vesicles via Incorporation of Unnatural Amino Acids ..................................................193Y. Li, J. Champion

Magnetic Nanostructure-loaded Bicontinuous Nanospheres for Magnetic Resonance Imaging and Drug Delivery .........................194M. Modak, V. Nandwana, V. Dravid, E. Scott

'Smart' Hydrogel for the Radiosensitization and Sustained Delivery of Therapeutics Triggered by X-Ray Irradiation .......................................................................................................................................................................................................195

M. Bouche, J. Hsu, D. Cormode

Biological Characterization of Intelligent Nanogels Synthesized by Inverse Emulsion Polymerization ..............................................196J. Clegg, J. Sun, E. Ander, A. Venkataraman, N. Peppas

PROTEIN AND CELLS AT INTERFACES SIG Secreted Factors from Macrophages Reduce Valvular Interstitial Cell Myofibroblast Activation......................................................197

J. Grim, B. Aguado, K. Anseth

Unfoldable Supramolecular Single Chain Nanogel-based Integrin Ligand Tether Regulates Mechanosensing of Stem Cells ........................................................................................................................................................................................................198

X. Chen, D. S. Wang, K. Wei, L. Bian

High Throughput Screening of Random Heteropolymers that Stabilize Enzymes ................................................................................199S. Kosuri, M. Tamasi, A. Gormley

Cyclodextrin Polymer Coatings Resist Protein Adsorption and Mammalian Cell Adhesion in vitro ..................................................200G. Learn, E. Lai, H. Von Recum

The Effect of Varying Serum Concentrations on Cell Motility in Wicking Fiber Systems ...................................................................201K. Burg, T. Ng, R. Marti

Structures Related Adsorption Behavior of Mussel Adhesive Protein (Mefp-5) on Different Biomaterial Surfaces .........................202Y. Wei, C.-F. Lin, K.-L. Chen, W.-Y. Su

Adsorption and Bioactivity of Bone Morphogenetic Protein-2 on Strontium-substituted Hydroxyapatite Surfaces.........................203B. Huang, Y. Lou, Y. Yuan, C. Liu

GUIDED TISSUE REGENERATION Chitosan Electrospun Membranes for Bone Regeneration – An in vivo Study in a Rat Calvarial Critical Sized Defect ...............................................................................................................................................................................................................204

F. Delbuque Guerra, N. Ghadri, H. Su, J. Bumgardner

Drug-loaded Elastin-like Polypeptide-Collagen Composites for Bone Tissue Engineering ...................................................................205P. Pal, Q. Nguyen, A. Janorkar

Evaluation of Poly(ε-caprolactone) Auxetic Knitted Scaffolds for Regeneration of Craniofacial Skeletal Muscle ............................206M. Deshpande, L. Katz, A. West, R. Shah, M. King

Hydrogels with Ultra-dynamic Network and Statically-tethered Ligands Enhance Mechanosensing-Dependent Activities of Encapsulated Stem Cells ..........................................................................................................................................................207

L. Bian, B. Yang, K. Wei

3D Hydrogel System to Promote Distinct Arterial-venous Specification of Endothelial Progenitor Cells for Tissue-engineered Vasculature..................................................................................................................................................................................208

B. Mahadik, R. Frayman, J. Fisher

Poly(Ethylene Glycol)-Crosslinked Gelatin Hydrogel Substrates with Conjugated Bioactive Peptides as a Basement Membrane Mimic for Endothelial Cell Culture........................................................................................................................209

J. Su, S. Satchell, J. Wertheim, R. Shah

NEXT-GENERATION BIOMATERIALS FOR TREATMENT OF TYPE 1 DIABETES Assembly of a Laminin-Nidogen Peri-Islet Matrix Improves Islet Function and Viability in PEG Hydrogels ..................................210

J. Simonovich, Y. Gonzalez-Vargas, N. Abuid, K. Ling, M. Becker, C. Stabler, E. Phelps

Engineering Transferrable Microvascular Meshes for a “Subcutaneous Pancreas” .............................................................................211M. Ma

Phase-Changing Antioxidant Scaffold Shows Promise for Omentum Islet Transplantation: A Non-Human Primate Case Study .......................................................................................................................................................................................................212

J. Burke, Y. Zhu, X. Zhang, J. Post, D. Kaufman, X. Luo, G. Ameer

Methacrylic-Acid Based Polymer Coating of Polypropylene Mesh Device Improves Subcutaneous Islet Engraftment ....................................................................................................................................................................................................213

V. Coindre, S. Kinney, M. Sefton

Preventing Cell Death and Dysfunction for Human-sourced Beta Cells via Oxygen-generating Disk ................................................214J. Liang, M. Coronel, C. Stabler

3D-Printed Vascularizing Device for Immunoisolation of Islets ...............................................................................................................215S. Parkhideh, D. Sazer, G. Calderon, I. Kintslinger, Y. Wang, J. Oberholzer, J. Miller, O. Veiseh

DENTAL/CRANIOFACIAL BIOMATERIALS SIG Novel Polymeric Dental Resins with Antibacterial Properties ..................................................................................................................216

D. Bienek, S. Frukhtbeyn, U. Okeke, A. Giuseppetti, S. Khajotia, F. Esteban Florez, R. Hiers, D. Skrtic

Oxidation-Responsive, Nanolayered Coatings for On-Demand Therapeutic Delivery to Craniofacial Bone Defects........................217J. Martin, M. Howard, S. Wang, P. Hammond

Novel Smart Dental Composite with Rechargeable Antimicrobial Capability .......................................................................................218S. Orrego, J. Londoño, W. Kosater, S. Correa

Biodegradable Shape Memory Polymer (SMP) Semi-Interpenetrating Networks (Semi-IPNs) with Highly Tunable Properties for Bone Regeneration ................................................................................................................................................................219

M. Pfau, K. McKinzey, A. Roth, M. Grunlan

In vivo Evaluation of Biocompatibility, Degradability, and Bone Regenerative Potential of Collagen-Elastin-like Polypeptide-Bioglass Composite Scaffolds ..................................................................................................................................................220

B. Gurumurthy, M. Tucci, L.-W. Fan, H. Benghuzzi, P. Pal, G. Bidwell, S. Salazar Marocho, Z. Cason, A. Janorkar

A Preliminary Electrochemical and Ion Release Assessment of the Essure® Medical Device ..............................................................221C. Aslan, J. Gilbert

Enhanced Osseointegration of Zn-Mg Composites by Tuning the Release of Zn Ions with Sacrificial Mg Rich Anode Design...................................................................................................................................................................................................222

Y. Zheng

Accelerated and Uniform Degradation of Pure Iron through Tantalum Incorporation for Medical implants ..................................223M. Lee, T.-S. Jang, H.-E. Kim, C. Park, H. Lee

RECENT ADVANCES IN ANTIMICROBIAL AND ANTIBIOFILM MATERIALS 1 Dual Antibacterial Drug Loaded Nanoparticles Synergistically Improve Anti-Oral Biofilm Treatments ..........................................224

K. Sims Jr., B. He, J. Maceren, Y. Liu, G. Hwang, H. Koo, D. Benoit

Optimization of PLGA Nanoparticles for Encapsulation of Enzyme for Elimination of Bacterial Biofilms.......................................225A. Doiron, C. Han, J. Goodwine, K. Sauer

Codelivery of Lysostaphin and BMP-2 to Eliminate Acute Infections and Heal Critical-sized Segmental Bone Defects ..............................................................................................................................................................................................................226

P. Kalelkar, C. Johnson, A. Garcia

Delivery of Bupivacaine and Tolfenamic Acid from Ultra-High Molecular Weight Polyethylene: Multimodal Pain Relief and Synergistic Antibacterial Properties from Total Joint Implants ............................................................................................227

S. Grindy, D. Gil, S. Hugard, O. Muratoglu, E. Oral

Investigating Antibiofilm Properties of IDR-1018 Peptide Loaded Hydrogels .......................................................................................228S. Shukla, A. Shukla

Biomimetic Phage Mimicking Antimicrobial Nanoparticles for Antibiotic Free, Bactericidal Action Against the ESKAPE Class of Pathogens .........................................................................................................................................................................229

J. Hopf, V. Kalwajtys, M. Waters, F. Fields, S. Lee, P. Nallathamby

IMMUNOMODULATORY BIOMATERIALS Nanomaterial Vaccines to Overcome Poor Immune Response in Gut Microbiome-mediated Metabolic Syndrome.........................230

A. Singh, M. Mosquera, S. Kim, H. Zhou, I. Brito

Bridging the Gap Between Systemic Vaccine and Mucosal Immunity to Fight Cancer ........................................................................231S. Ferber, U. Von Andrian, R. Langer, N. Artzi

Enhanced T-cell Immunity in vivo Using Cell-instructive Scaffolds ........................................................................................................232N. Shah, A. Mao, T.-Y. Shih, M. Kerr, D. Mooney, D. Scadden

The Biologic Scaffold Immune Microenvironment Inhibits Tumor Formation and Synergizes with Immunotherapy ..............................................................................................................................................................................................233

M. Wolf, J. Elisseeff, S. Ganguly, R. Narain, K. Sadtler, D. Pardoll

Combinatorial, Microparticle-based Delivery of Immune Modulators Reprograms Dendritic Cell Phenotype and Promotes Remission of Collagen-induced Arthritis in Mice .....................................................................................................................234

R. Allen, J. Lewis, S. Raychaudhuri, L. McKibbin, S. Chizari

Immunomodulatory Biomaterials to Improve Allogeneic Islet Graft Survival in a Murine Diabetic Model......................................235M. Coronel, J. Weaver, M. Hunckler, E. Yolcu, H. Shirwan, A. Garcia

Biomimetic Apoptotic Erythrocyte Membrane-Coated Microparticles for Enhanced Tolerance Induction ......................................236K. Rhodes, R. Meyer, C. State, J. Green

A Bacterial Membrane Coated Nanoparticle in Combination with Radiation Therapy for In Situ Tumor Vaccination......................................................................................................................................................................................................237

M. Ye, R. Patel, P. Carlson, B. Ma, Y. Wang, L. Zangl, I. Arthur, P. Sondel, Z. Morris, S. Gong

NEXT-GEN TISSUE ADHESIVES AND CLINICAL APPLICATIONS Elastagen: Commercial Translation of a Biomaterial from Lab to Trade Sale ......................................................................................238

A. Weiss

In vivo Evaluation of Bioadhesive and Biodegradable Closure Device for Sealing of Femoral Artery Punctures .............................239M. Kim, E. Lih, S. Lee, D. Lee, Y. Choi, Y. Joung, S. Park, C. J. Yoon, H.-H. Jung

Novel Measurement Method for Cyanoacrylates Polymerization Thermal Properties .........................................................................240K. Garcia, J. Corbett, M. Taylor

Bioinspired Elastin-based Protein Adhesives ..............................................................................................................................................241J. Liu, S. Hollingshead, C.-Y. Lin, J. Wilker

An Effective Post-Operative Adhesion Barrier Utilizing Physical Hydrogels.........................................................................................242E. Appel, Y. J. Woo, L. Stapleton

BIOMATERIAL-TISSUE INTERACTION SIG Assessment of in vivo Degradation of Polypropylene Hernia Mesh .........................................................................................................243

X. Lu, B. Cotton, T. Heniford, V. Augenstein, M. Harman

Toll-like Receptor Activation by Adsorbed Damage-Associated Molecular Patterns on Polymeric Surfaces ....................................244L. McKiel, K. Woodhouse, L. Fitzpatrick

Neuronal Cell Adhesion Molecule L1 Improves Quality of Chronic Neural Recording in Mouse Visual Cortex ..............................245A. Golabchi, K. Woeppel, X. Cui

The Role of Toll-like Receptors 2 and 4 in the Foreign Body Response to Poly(ethylene glycol) Hydrogels.......................................246L. Saleh, D. Faulon Marruecos, S. Thomas, W. Janssen, S. Alper, D. Schwartz, J. Kaar, S. Bryant

Resveratrol Delivery from Porous Poly(lactide-co-glycolide) Scaffolds Promotes an Anti-inflammatory Environment within Visceral Adipose Tissue .............................................................................................................................................247

M. Gower, K. Murphy, M. Hendley, C. Isely, P. Annamalai

The Anti-PEG Immune Response: Fact, Fiction, or a Legitimate Concern for Biomaterials? .............................................................248A. Isaac, V. Winklepleck, D. Alge

Differential Degeneration Patterns of the Proximal and Distal Stumps in a Sciatic Gap-Injury Model in the Rabbit Highlight the Role of Gap-Length in Preventing Regeneration ................................................................................................................249

A. Merolli, W. Chang, J. Am. Steele, A. Pastino, J. Kohn

Interaction of a Secreted Disulfide Bond Catalyst with the Extracellular Matrix in Pancreatic Cancer ............................................250C. Millar-Haskell, J. Gleghorn

ENGINEERING CELLS AND THEIR MICROENVIRONMENTS SIG Understanding the Role and Timing of the Pericellular Matrix at the Cell-Hydrogel Interface ..........................................................251

M. Kwon, C. Loebel, T. Duan, R. Mauck, J. Burdick

Microgel Thin Film Loss Tangent and Substrate Elasticity Direct Cell Spreading and Migration Responses...................................252D. Chester, J. Nortey, R. Kathard, R. Lee, A. Brown

Interplay Between Degradability and Integrin Signaling on Mesenchymal Stem Cell Function within Porous Poly(ethylene glycol) Microgel Scaffolds .....................................................................................................................................................253

S. Xin, C. Gregory, D. Alge

Exploiting Biomaterial-modulated Secretome Production in Artificial Stem Cell Niches.....................................................................254A. Gilchrist, B. Harley

Mechanobiologically-Activated, Scaffold-free Transplantation of Stem cells to Repair Injured Cardiac Tissues .............................255A. Paul, A. Chakravarti, S. Pacelli, P. Alam, S. Modaresi, R. Ahmed

Hepatoblast Organoids Have Potential for Bipotential Differentiation in Engineered Liver Tissue ...................................................256S. Saxton, A. Ross, L. Vallier, K. Stevens

Fatty Acid Based Media Enhances Maturity and Ability to Predict Pharmacology in Human iPS-Cell Derived Cardiomyocyte Based Microphysiological Systems....................................................................................................................................257

N. Huebsch, B. Charrez, B. Siemons, S. Boggess, V. Charwat, N. Jeffreys, F. L. Montiel, A. Edwards, S. Wall, K. Healy

Valvular Myofibroblast Persistent Activation Requires Global Chromatin Condensation ..................................................................258C. Walker, A. Killaars, J. Grim, L. Leinwand, K. Anseth

DRUG DELIVERY SIG Synthetic Glycopolymer Prodrugs for Targeted Antimicrobial Delivery in the Lung ...........................................................................259

D. Ratner, J. Chen, F.-Y. Su, P. Stayton

Affinity-based Polymer Extends Drug Delivery and Retention for Wound Healing in the Esophagus ...............................................260N. Rohner, S. Schomisch, J. Marks, H. Von Recum

In Situ Sprayed Gel with Anti-CD47 for Post-Surgical Cancer Immunotherapy...................................................................................261Q. Chen, G. Chen, G. Dotti, Z. Gu

Sustained and Prolonged Delivery of Protein Therapeutics Using 2D Nanosilicates .............................................................................263A. Gaharwar, L. Cross, J. Carrow, K. A. Singh

Conductive Microneedles for Transdermal Delivery in Dentistry............................................................................................................264C. Xu, R. Z. Seeni, Y. Liu, B. T. Goh

Nanoparticle Dopants Enhance Electrically Controlled Drug Release from Conducting Polymer Coatings......................................265K. Woeppel, S. Zheng, T. Cui

CARDIOVASCULAR BIOMATERIALS SIG Transmembrane SCF Nanodiscs Enhance Revascularization in Ischemia and Induce CD34-/CD133+ Endothelial Progenitor Cells ..............................................................................................................................................................................................266

E. Takematsu, J. Auster, A. Singh, P.-C. Chen, S. Canga, A. Degroot, M. Sherman, J. Stachowiak, A. Dunn, A. Baker

Biophysical Characterization of Murine Hearts for Engineered Cardiac Tissue Mimics .....................................................................267D. Bousalis, C. Lacko, P. Lim, H. Kasahara, C. Schmidt

Composite Bioresorbable Cardiovascular Stents Braided from Poly(p-dioxanone) and Polycaprolactone Yarns ............................268F. Zhao, F. Wang, M. King, L. Wang

A Precision-Porous Polyurethane Material for In-situ Tissue-Engineered Vascular Grafts ................................................................269L. Zhen, F. Simonovsky, S. Creason, B. Ratner

Designing a Porous Hydrogel Pouch to Limit Adhesions During in vivo Vascular Graft Maturation ................................................270M. Sameti, M. Shojaee, K. Vuppuluri, M. Ziff, A. Carriero, C. Bashur

The Potential of Polyester Fibrous Leaflets for Transcatheter Heart Valves..........................................................................................271F. Heim, N. Chakfe, A. Yousefi, P. Lakshmi, A. Vaeksen

In Vitro Fatigue Evaluation of a Patient-specific Chimney Approach to Endovascular Aneurysm Repair........................................272M. King, R. Zhang, S. Crawford, T. Forbes, I. Robertson, J. Cole

The Impact of Electrically Conductive and Non-Conductive Nanocomposite Hydrogels on Functionalities of Engineered Cardiac Tissues ..........................................................................................................................................................................273

M. Nikkhah, A. Navaei

MULTIFUNCTIONAL BIOMATERIALS: RECENT DEVELOPMENTS AND FUTURE DIRECTIONS Functionalized Glycopolymer Materials for Improving Detection for Glycan Interactions .................................................................274

A. Michalak, K. Godula

A Membrane Logic Gate to Control Secretion from Vesicles ...................................................................................................................275N. Kamat, C. Hilburger, K. Lewis, M. Jacobs

Aza-Michael Addition Cross-Linking Strategy for Formation of Dendrimer Hydrogels, Micro/Nanogels, and Cryogels ...........................................................................................................................................................................................................276

J. Wang, H. Yang

New Textured Polyphosphazene Biomaterials with Improved Biocompatibility....................................................................................277L.-C. Xu, C. Chen, H. Allcock, C. Siedlecki

Multi-functional Conductive Self-Healing Hydrogels with Pressure Sensitivity, Stretchability, and 3D Printability .......................278M. Xing, M. Darabi

Extent and Type of Modification of Hyaluronic Acid Influence CD44 Binding in Soluble and Hydrogel Forms ..............................279M. Kwon, C. Wang, L. Han, J. Burdick

Capsule Integrated Polypeptide Multilayer Films for On-Demand Multiple Drug Co-Delivery..........................................................280S. Zhang, B. Li

Strain-induced Stiffening of Fibrous Biomaterials Through Dynamic Covalent Chemistry ................................................................281M. Davidson, A. Schoonen, M.-H. Lee, E. Bonnevie, R. Mauck, J. Burdick

ENGINEERING REPRODUCTION Rescuing the Primary: Lessons Learned from Inter-follicular Synergy ..................................................................................................282

A. Jones, H. Zhou, A. Shikanov

Reconstructing the Ovarian Microenvironment: Culturing Follicles in an ECM-Sequestering PEG Matrix ....................................283C. Tomaszewski, I. Kopyeva, A. Shikanov

Bovine Ovary-derived Extracellular Matrix Hydrogel Supports in vitro Growth of Bovine Early Antral Follicles .........................284E. Gargus, H. C. Lee, J. Zhang, T. Woodruff

Immunoisolating Poly(ethylene glycol)-Vinyl Sulfone Matrix Prevents Cancer Cells from Spreading Following Ovarian Tissue Autotransplantation............................................................................................................................................................285

A. David, J. Day, M. Hammersley, C. Long, A. Shikanov

Dual Phased Poly(ethylene glycol) Immunoisolating Capsule Supports Ovarian Tissue Development and Precludes Sensitization of the Host Immune Response................................................................................................................................................286

J. Day, A. David, M. Hammersley, M. Barbosa, M. Cascalho, A. Shikanov

Development of a Biomaterial Model of the Decidualized Endometrium................................................................................................287S. Zambuto, B. Harley

TISSUE ENGINEERING SIG Conductive Inks for 3D Printing from Jammed Hyaluronic Acid Microgels..........................................................................................288

M. Shin, K. H. Song, J. Burdick

3D Bioprinting with an Engineered Elastin Like Protein (ELP) ..............................................................................................................289K. Lampe, E. Meco, M. Azimi, A. Sharma, M. Hefferon, D. Meador, B. Corliss, M. Rikard, H. Shariff, S. Peirce

Evaluating the Effect of Elastin in the Angiogenic Response of Silk Fibroin 3D Printed Scaffolds .....................................................290J. Silva-Correia, L. Costa, J. Costa, J. Oliveira, R. Reis

Highly Elastic, Biodegradable Hydrogel with Shear-thinning Properties for Bioprinting ....................................................................291C. Xu, W. Lee, G. Dai, Y. Hong

Contractile Imbalance of Human Cardiac Microtissues on the Mechanical Hybrid Filamentous Matrices .......................................292Z. Ma, C. Wang, S. Koo, P. Hoang, C. Grigoropoulos, K. Healy

Engineered Liver Tissue as an in vivo Model to Probe the Dynamics of Human Liver Regeneration Over Time .............................293C. Fortin, S. Saxton, F. Johansson, K. Stevens

Rapid Encapsulation of Cells in Hydrogel Microspheres Using A Novel Microfluidic Platform .........................................................294Y. Tian, W. Seeto, S. Pradhan, P. Kerscher, E. Lipke

Proteome-wide Analysis of Cellular Response to Ultraviolet Light for Photoresponsive Biomaterials ...............................................295E. Ruskowitz, C. Deforest

NON-VIRAL DELIVERY FOR GENE THERAPY AND EDITING Dendrimer-based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I ..............................................................................................................296

D. Siegwart, Q. Cheng, T. Wei, Y. Jia, L. Farbiak, K. Zhou, S. Zhang, H. Zhu

Non-viral Intracellular mRNA Delivery in Human Primary Cytotoxic T Lymphocytes Using Synthetic Lipidoid Nanoparticles ..................................................................................................................................................................................................297

X. Zhao, Q. Xu

Carboxylated Branched Poly(B-amino ester) Nanoparticles Enable Robust Intracellular Protein Delivery and CRISPR/Cas9 Gene Editing ..........................................................................................................................................................................298

Y. Rui, D. Wilson, K. Sanders, J. Green

Polymer Nanoparticles for Secreted TRAIL Cancer Therapy..................................................................................................................299H. Vaughan, C. Zamboni, N. Radant, P. Bhardwaj, D. Francisco, J. Green

Combinatorial Therapy of siMDR1 and Doxorubicin to Overcome Drug Resistance in Breast Cancer Models ...............................300J. Lee, D. Oglesby, W. Cornett

Flash Nanocomplexation as a Scalable Production Method for Therapeutic pDNA/lPEI Nanoparticles............................................301H.-W. Liu, Y. Hu, I. Minn, H.-Q. Mao

Characterization of Long-term Stability of PgP/pGFP Polyplexes with Varying Cryoprotectants .....................................................302J. S. Lee, J. Woo, K.-T. Kim, C. Macks

Dendritic Lipopeptides for High Gene Transfection Efficiency with Structure Optimization by Molecular Dynamic Simulation........................................................................................................................................................................................................303

H. Liang, III, X. Chen, A. Hu, R. Jin, K. Wang, Y. Nie

RECENT ADVANCES IN ANTIMICROBIAL AND ANTIBIOFILM MATERIALS 2 Influence of Poly-L-Lysine Molecular Weight on Antibacterial Activity of Polyelectrolyte Multilayer Films ...................................304

A. Shukla, D. Alkekhia

Nano-patterned Bacterial Cellulose Hydrogel Exhibits Bactericidal Activity Against E. coli and K. pneumoniae............................305S. Arias, M. K. Cheng, A. Civantos, J. Devorkin, C. Jaramillo, J. P. Allain

Adhesive Antimicrobial Wraps to Treat Infection and Improve Bone Regeneration ............................................................................306T. Buie, J. McCune, E. Cosgriff-Hernandez

Biomimetic Recyclable Microgels for On-demand Generation of Hydrogen Peroxide and Antipathogenic Application ......................................................................................................................................................................................................307

R. Pinnaratip, H. Meng, P. Kord Forooshani, P. Joshi, J. Osborne, X. Mi, M. Frost, C. Heldt, B. Lee, C. Meingast

Evaluation of Blended Chitosan/Polyol injectable Paste in an in vitro Model of Osteomyelitis............................................................308L. Pace, Z. Harrison, J. A. Jennings

Bacteriophage Delivering Hydrogels Reduce Biofilm Formation in vitro and Infection in vivo...........................................................309J. Wroe, C. Johnson, A. García

BIOMATERIAL TECHNOLOGIES FOR HEMOSTASIS AND WOUND CARE Modular Amplification of Hemostatic Output with Platelet-inspired Particles using Clot-augmenting Nanomaterials .................................................................................................................................................................................................310

U. D. S. Sekhon, N. Luc, K. Swingle, A. Sen Gupta

Stiffness-dependent Toxicity of Platelet-like Particles ............................................................................................................................... 311J. Nicosia, D. Chambers, M. Fay, D. Abebayehu, M. Harp, S. Landes, A. Brown, W. Lam, T. Barker

Porcine Wound Healing Testing of ROS-degradable Poly(thioketal) Urethane Scaffold Variants ......................................................312P. Patil, J. Martin, A. Pollins, N. Cardwell, J. Davidson, S. Guelcher, L. Nanney, C. Duvall

Self-Healable and Sustained Release Zwitterionic Cryogels for Wound Healing ...................................................................................313J. Newsom, M. Krebs, G. Sener, S. Hilton, C. Zgheib, S. Singh, S. Seal, K. Liechty

Ultrasound Stimulation Enhances Platelet-like Particle Mediated Matrix Deformation to Improve Healing Outcomes .........................................................................................................................................................................................................314

S. Nandi, A. Joshi, K. Mohanty, E. Sproul, M. Muller, A. Brown

A Flexible Electronic/Smart Hydrogel Integrated System for Real-Time Infection Monitoring and Dynamic Treatment ........................................................................................................................................................................................................315

Q. Pang, D. Lou, C. Gao, M. Lie

Chromophore-free Tissue Sealing and Repair using Mid Infrared Lasers .............................................................................................316I. Ridha, A. Basiri, S. Gudesala, D. Gosh, J. Keun Lee, J. Kilbourne, Y. Yao, K. Rege

Noninvasive Photochemical Epithelial Tissue Bonding Using Upconversion Nanoparticles / Hyaluronate – Rose Bengal Conjugate Complex ...........................................................................................................................................................................317

S. K. Hahn

SURFACE CHARACTERIZATION AND MODIFICATION SIG ImageJ and Atomic Force Microscopy Characterization of Drug-stabilized Microtubules ..................................................................318

Y.-L. Chiang, J. Zhou, S. Wu, K. Richardson, D. Sackett, A. Jin

Surface Conjugation of Anti-fouling Polymers via Pyrogallol-based Chemistry....................................................................................319S.-L. Yeh, W.-B. Tsai

Synthetic Glycocalyx on Cell Surfaces for Enhancing Anti-tumor Responses of Immune Cells ..........................................................320H. Chen, Q. Liu, G. Chen

Analysis of Shear Forces Between Satellite Telemetry Tag and Whale Blubber in a Drag Force Simulation ....................................321E. Bloch, R. Jones, E. Johnson, J. Jiang, A. Zerbini, J. Robbins, R. Rajachar

Surface Modification Using Elastin-Like Polypeptide and Polyethyleneimine for Three-Dimensional Cell Cultures.......................322J. Cobb, P. Pal, A. Janorkar

Incorporation of Biochemical Stimuli by Surface Coating Fiber Based Scaffolds for Tissue Engineering a Tendon-Bone Junction..................................................................................................................................................................................................323

H. Ramakrishna, M. King

Synthesis and Characterization of a Novel Porous Bioactive SiC Tissue Engineering Scaffold ...........................................................324M. Greenier, I. Marriott, M. Johnson, A. El-Ghannam

Photocatalytic Activity and Antibacterial Efficacy of UVA-Treated Titanium Oxides .........................................................................325H. Johnson, A. Janorkar, M. Marquart, R. Williamson, M. Roach

BIOELECTRONICS AND BIOSENSORS Conformal Electrode Arrays to Enable in vivo Recordings of the Enteric Nervous System .................................................................326

M. Ecker, E. Guerrero, P. Rocha Flores, W. Voit

Integration of Micropillars in Human iPS-Cell Derived Cardiomyocyte Based Microphysiological Systems for Contraction Force Measurement Enables Precise Monitoring of Pharmacology and Maturation Studies.........................................327

B. Charrez, N. Huebsch, V. Charwat, B. Siemons, S. Boggess, N. Deweshwar, A. Stahl, E. Miller, K. Healy

Biodegradable Piezoelectric Force Sensor for Monitoring Biological Pressures ....................................................................................328T. Nguyen

Flexible Nanofiber-Based Materials for Material Property-Matched Neural Interfacing ....................................................................329J. D. Remer, M. Skoff, C. Tison, K. Yoshida, A. Joshi-Imre, L. Costella

A Flexible and Electrically Stable Conductive Polypyrrole Membrane for Biomedical Applications .................................................330Z. Zhang, J. Mao, S. Cui, M. Rouabhia

Immobilized Liquid Coatings for Implantable Neural Electronics ..........................................................................................................331A. Rutz, A. Carnicer-Lombarte, D. Barone, G. Malliaras

BIOMATERIALS FOR REGENERATIVE ENGINEERING 1 MicroRNA-200c Incorporated 3D-Printed Tricalcium Phosphate Enhances Bone Regeneration .......................................................332

M. Remy, A. Akkouch, L. He, M. Sweat, F. Qian, X. Song, B. Amendt, L. Hong

Biomolecule Delivery to Synergistically Mobilize and Locally Recruit Bone Marrow Cells Enhances Muscle Regeneration Following Rotator Cuff Tear.................................................................................................................................................333

L. Anderson, L. Tellier, A. Brimeyer, E. Botchwey, J. Temenoff

BMP-2 Modified Fiber Meshes to Facilitate Bone Integration for Ligament Reconstruction ..............................................................334A. Goldstein, D. Gadalla

Synthesis and Characterization of Osteoinductive Adhesive Composites with Antimicrobial Properties...........................................335N. Annabi, R. Portilo Lara, A. Moghanian, E. Shirzaei Sani, H. Konisky

Engineering 3D Skeletal Muscle Primed for Neuromuscular Regeneration Following Volumetric Muscle Loss ..............................336Jordana Gilbert-Honick, Shama R. Iyer, Sarah M. Somers, Richard M. Lovering, Kathryn R. Wagner, Hai-Quan Mao, Warren L. Grayson

Microporous Annealed Particle Hydrogel-based Muscle Repair in Rat Model of Volumetric Muscle Loss.......................................337A. Rodriguez Ayala, S. Shah, D. Griffin, G. Christ

BIOMATERIALS FOR THERAPEUTIC DRUG DELIVERY 1 Sustained Delivery of Glycogen Synthase Kinase Inhibitor AR28 Is Critical for Osteogenic Selectivity in MSCs ............................338

D. Benoit, M. Newman, M. Ackun-Farmmer, Y. Wang, B. Xiao, J. E. Puzas

Supramolecular PEGylation as an Innovative Approach to Biopharmaceutical Formulation and Delivery......................................339E. Appel, C. Maikawa, A. Smith

Logical Stimuli-Triggered Delivery of Small Molecules from Hydrogel Biomaterials...........................................................................340C. Deforest, E. Ruskowitz, M. Comerford, B. Badeau

Assessment of Antioxidant Copolymers for Improved ROS Scavenging in Post Traumatic Osteoarthritis .......................................341A. Miskalis, B. Dollinger, C. Dejulius, C. Duvall

Heparin-based IL-12 Complex Coacervate Inhibits B16F10 Melanoma Tumor Progression ..............................................................342M. Hwang, R. Fecek, T. Qin, W. Storkus, Y. Wang

Polybubble Depots Functioning as a Theranostic-enabling Anti-cancer Platform Technology............................................................343S. Arun Kumar, J. Good, D. Hendrix, W. Souery, Y.-Y. Jhan, C. Bishop

Design of Semi-Randomized Zwitterionic Peptides to Prevent Serum Aggregation of Polymeric Nanoparticles ..............................344C. Overby III, D. Benoit

Nanofiber-based Opioid Bandages for Localized Treatment of Burn Pain.............................................................................................345M. Skoff, M. Patterson, J. Mao, Z. You, C. Tison

SFB BUSINESS PLAN COMPETITION *BTI* SAPHTx: Injectable Hydrogel for Treating Neovascular Ocular Diseases .............................................................................................346

B. Sarkar, P. Nguyen, Z. Siddiqui, V. Kumar

Evoke Medical, LLC: PiezoNail -- Stimulating a Pathway to Better Fracture Healing........................................................................347Z. Pessia, C. Cunningham, E. Krech, E. Friis

HumeurVitrée : Revolutionizing Retinal Detachment Surgery ................................................................................................................348F. Lasowski, B. Muirhead, H. Sheardown

B-CULTURE...................................................................................................................................................................................................349R. Canadas, J. Oliveira, A. Marques, R. Reis

DEVELOPING BETTER BIOMATERIALS: ADVANCES IN TECHNOLOGIES AND UNDERSTANDING OF SURFACE MODIFICATION Enzyme-Mediated Peptide Decoration of Silk Fibroin-based Hydrogels.................................................................................................350

M. McGill, J. Grant, D. Kaplan

A Less-Explored Surface Property: The Electrical Double Layer and Its Molecular Interrogation Capability ................................351G. Zhang, Y. Zhao, S. Bearden

Catalyzed Nitric Oxide Release Via Cu Nanoparticles Leads to Increase in Antimicrobial Effects and Hemocompatibility for Short Term Extracorporeal Circulation .............................................................................................................352

M. Douglass, M. Goudie, J. Panta, P. Singha, S. Hopkins, H. Handa

Ultra-low Fouling Biocompatible Polycarboxybetaine Coatings ..............................................................................................................353K. Wu, H.-C. Hung, P. Zhang, S. Jiang

Effect of Bone Remodeling Coupling Factors on Osteogenic Differentiation of Human Mesenchymal Stem Cells Induced by Microstructured Titanium Surfaces ........................................................................................................................................354

J. Deng, D. Cohen, Z. Schwartz, B. Boyan

Promoted Osteoconductivity of Titanium with Chessboard-patterned Surface Nano Topography Fabricated by Femtosecond Laser Irradiation.....................................................................................................................................................................355

P. Chen, K. Takenaka, M. Tsukamoto, M. Ashida, Y. Tsutsumi, H. Doi, T. Hanawa

FUNCTIONAL BIOMATERIALS TO CONTROL AND DIRECT CELLULAR FUNCTION 1 Soft Hydrogel as Cell Culture Substrate to Direct MSCs Proangiogenic Potential through ROS-NRF2-HIF Signaling ..........................................................................................................................................................................................................356

H. Yang, C. Y. Tay, M. K. H. Lee

Hydrogel Surfaces Promote MSC Expansion and Proregenerative Priming for Rotator Cuff Muscle Healing.................................357M. Ogle, G. Doron, M. Levy, J. Temenoff

Hydrogel-based in vitro Glioblastoma Spheroid Models ...........................................................................................................................358L. Hill, M. Imaninezhad, J. Ortlund, J. Conley, S. Zustiak

Nascent Protein Secretion Directs Cell Mechanosensing and Function in Three-Dimensional Hydrogels..........................................359C. Claudia, R. Mauck, J. Burdick

Injectable Composite Hydrogels for Bone Repair in a Sheep Bone Defect Model..................................................................................360M. Gionet-Gonzales, G. Ingavle, C. Vorwald, L. Bohannon, K. Clark, L. Galuppo, K. Leach

The Role of Substrate Stiffness in Stem Cell Transfection of Plasmid Dna Using Lipid-Based Nanocarriers....................................361S. Modaresi, S. Pacelli, J. Whitlow, A. Paul

OPHTHALMIC BIOMATERIALS SIG ECM Protein Shrink-Wrapped Cells Demonstrate Enhanced Integration into Corneal Endothelium ...............................................362

R. Palchesko, Y. Du, J. Funderburgh, A. Feinberg

An Antioxidant-Releasing Hydrogel Vitreous Substitute ..........................................................................................................................363N. Tram, K. Jacobs, K. Swindle-Reilly

Fabrication of Swellable Microneedle using Methacrylated Hyaluronic Acid for Extraction of Biomarkers in Ocular Fluids...................................................................................................................................................................................................364

S. H. Park, J. Lee, W. Ryu

Injectable Biodegradable Bi-layered Capsule for Sustainable Delivery of Protein Therapeutics ........................................................365P. Jiang, J. Lannutti, M. Ohr, K. Swindle-Reilly

Radiolabeling Biopolymers and Synthetic Polymers for Precise Quantification ....................................................................................366L. Liu, H. Sheardown, D. Yang

Isolation and Characterization of Inner Wall Endothelial Cells of the Schlemm’s Canal Using a Citrate-based Polymer ............................................................................................................................................................................................................367

S. Ramachandra, A. Vahabikashi, M. Johnson, G. Ameer

Mucoadhesive Micelles for the Treatment of Dry Eye Disease .................................................................................................................368F. Lasowski, B. Muirhead, E. A. Hicks, T. Rambarran, N. Yasin, H. Sheardown

Properties of Acrylate Materials Under Different Storage Environments ..............................................................................................369C. Hu, M. Lowery

BIOMATERIALS FOR REGENERATIVE ENGINEERING 2 Aligned and Conductive 3D Collagen Scaffolds for Skeletal Muscle Tissue Engineering .....................................................................370

I. Basurto, M. Mora, G. Christ, S. Caliari

Effect of a Degradable Methacrylic Acid-Based Hydrogel on Macrophage Phenotype in Skeletal Muscle ........................................371M. Carleton, M. Sefton

Wnt7a-Releasing Hydrogel for Enhancing Local Skeletal Muscle Regeneration ...................................................................................372W. Han, S. Anderson, M. Mohiuddin, A. Garcia, Y. Jang

Sulfated Alginate to Sequester Endogenous Growth Factors Secreted by Mesenchymal Stem Cell Spheroids..................................373M. Gionet-Gonzales, K. Leach

Precision-Porous Templated Scaffolds Induce Unique Pro-Healing Cell and Exosome Populations...................................................374J. Bryers, B. Hwang, M. Mulligan, B. Ratner

Paper-Based Biomaterials for Personalized Medicine and Regenerative Engineering ..........................................................................375G. Camci-Unal

Hyperbaric Oxygen-Generating Hydrogels for Enhanced Wound Healing ............................................................................................376K. M. Park

Developing an Economical Fibrous Gelatin-Polyurethane Scaffold for Skin Regeneration..................................................................377M. Sheikholeslam, M. Wright, N. Cheng, H. H. Oh, S. Amini-Nik, P. Santerre, M. Jeschke

BIOMATERIALS FOR THERAPEUTIC DRUG DELIVERY 2 Locally Anchoring Proteins to Target Tissues via Fusion to Galectin-3 ..................................................................................................378

S. Farhadi, E. Bracho-Sanchez, M. Fettis, D. Seroski, S. Freeman, B. Keselowsky, G. Hudalla

Pulmonary Nanoparticle Delivery to Ameliorate Neuroinflammation of Experimental Autoimmune Encephalomyelitis...........................................................................................................................................................................................379

E. Saito, S. Gurczynski, K. Kramer, C. Wilke, B. Moore, L. Shea

Affinity Based Release of Protein Therapeutics to Treat Retinitis Pigmentosa ......................................................................................380C. Teal, V. Delplace, A. Ortin-Martinez, S. En-Leh Tsai, V. Wallace, M. Shoichet

Liver Targeted Primaquine Drugamers for the Treatment of Malaria in High Risk Settings..............................................................381S. Srinivasan, J. Conner, R. Rochford, K. Montgomerry, C. Leguyader, F. Su, P. Stayton, A. Convertine

Non-Invasive, Epicortical Delivery of Brain-Derived Neurotrophic Factor for Recovery After Stroke ..............................................382E. Ho, J. Obermeyer, A. Tuladhar, S. Payne, C. Morshead, M. Shoichet

Compositional Control of pDNA/lPEI Nanoparticles Using Flash NanoComplexation to Improve in vivo Transfection Efficiency and Biocompatibility .............................................................................................................................................383

Y. Hu, H.-W. Liu, I. Minn, M. Pomper, H.-Q. Mao

Tuning the Presentation and Density of Targeting Peptides on Polymeric Nanoparticles to Improve Bone Localization .....................................................................................................................................................................................................384

M. Ackun-Farmmer, Y. Yan, D. Fraser, D. Benoit

Towards a Nanoparticle-based Prophylactic for Maternal Autoantibody-related Autism ...................................................................385A. Bolandparvaz, R. Harriman, N. Vapniarsky, K. Alvarez, Z. Zang, J. Van De Water, J. Lewis

IMMUNE ENGINEERING SIG Human Pancreas Organ Slices as a Platform for Investigating the Immunopathological Processes of Type 1 Diabetes............................................................................................................................................................................................................386

E. Phelps, C. Mathews

Apolipoproteins are a Mediator of Tissue-Specificity in the Foreign Body Response............................................................................387K. Sadtler, C. Macisaac, F. Zepeda, J. Doloff, R. Langer, D. Anderson

Delivery of STING Agonist for Augmenting Adoptive T Cell Therapy ...................................................................................................388C. Park, J. Moon

Depleting Myeloid-derived Suppressor Cells with Janus Synthetic Nanoparticle Antibodies As A Cancer Immunotherapy ..............................................................................................................................................................................................389

J. Liu, R. Toy, P. Pradhan, K. Roy

Self-Assembly of Immune Signals to Identify Tolerogenic Factors in a Multiple Sclerosis Model .......................................................390R. Oakes, L. Tostanoski, C. Jewell

Effects of Tunable Degradation on Humoral, Cellular, and Protective Immune Responses Generated by a Universal Flu Vaccine Formulated with Acetalated Dextran Microparticles .........................................................................................391

K. Ainslie, N. Chen, M. Collier, M. Gallovic, J. Ting, E. Bachelder

Local Anchoring of Indoleamine 2, 3-Dioxygenase Ameliorates Inflammation......................................................................................392S. Freeman, E. Bracho-Sanchez, F. Rocha, S. Farhadi, S. Wallet, G. Hudalla, B. Keselowsky

Polymeric Nanoparticles Improve Antibody Delivery to Tumors and Tumor Draining Lymph Nodes to Enhance Cancer Immunotherapy via Checkpoint Inhibition ...................................................................................................................................393

D. Francis, A. Schudel, N. Rohner, S. Thomas

FUNCTIONAL BIOMATERIALS TO CONTROL AND DIRECT CELLULAR FUNCTION 2 Hyaluronic Acid-Based Hydrogels for Patient-Derived Xenograft Culture in a High Throughput Microfluidic Plate..................................................................................................................................................................................................................394

D. Harrington, L. Sablatura, K. Bircsak, P. Shepherd, N. Navone, P. Constantinou, A. Saleh

Dissecting the Influences of Combinatorial Microenvironment on Hepatic Stellate Cell Behavior and Phenotype...........................395I. Jain, A. Brougham-Cook, D. Kukla, S. Khetani, G. Underhill

High-throughput Mapping of Nanotopographies-Regulated Cell Behaviors by Large-scale Combinatorial Nanoarrays ......................................................................................................................................................................................................396

L. Yang, K.-B. Lee

Microclot Array Elastometry for Integrated Measurement of Clot Biomechanics Under Fluid Shear ...............................................397R. Zhao, Z. Chen, J. Lu, C. Zhang, S. Neelamegham

Extracellular Matrix Enriched Spheroids for Enhanced Survival and Differentiation of Mesenchymal Stem Cells.........................398T. Gonzalez-Fernandez, A. Keown, A. Tenorio, K. Leach

A Microfluidic Method for Creating Poly(ethylene glycol) Gradient Microgel Scaffolds to Modulate Human Mesenchymal Stem Cell Behavior ................................................................................................................................................................399

S. Xin, J. Dai, A. Han, D. Alge

Photocrosslinked Bioglass Incorporated Methacrylated Collagen Hydrogels for Orthopedic Applications.......................................400N. Kajave, T.-U. Nguyen, T. Schmitt, M. Fenn, V. Kishore

Tendon Mimetic Magnetic Responsive Fibrous Scaffolds and Magneto-mechanical Stimulation Synergistically Promotes the Tenogenic Commitment of Human Adipose Derived Stem Cells......................................................................................401

R. Domingues, A. Tomás, A. Gonçalves, R. Reis, M. Gomes

ENGINEERED BIOMATERIALS FOR NEURAL APPLICATIONS 2 Probing Extracellular Matrix Structural Changes in Organotypic Rat Brain Slices Using Multiple Particle Tracking ..........................................................................................................................................................................................................402

M. McKenna, H. Pontes, E. Nance

Hyaluronic Acid-Based Hydrogels as a 3D Culture Platform for Neural Stem/Progenitor Cells.........................................................403S. Seidlits

Ile-Lys-Val-Ala-Val and Leu-Arg-Glu Peptide Signaling in Combination with Matrix Metalloprotease Cleavable Crosslinkers Alter Extracellular Matrix Degrading Enzyme Expression and Axon Extension in Encapsulated Human Induced Pluripotent Stem Cell Derived Neural Stem Cells .........................................................................................................404

L. Smith Callahan, T. H. Perera

Redesigning SDF-1 Delivery Strategies with in vitro, in vivo, and in silico Analyses.............................................................................405K. Hickey, S. Grassi, M. Caplan, S. Stabenfeldt

SilkBridge: A Novel Biomimetic and Biocompatible Silk-based Nerve Conduit ....................................................................................406G. Bassani, M. Biagiotti, L. Muratori, V. Vincoli, G. Ronchi, A. Alessandrino, S. Geuna, G. Freddi

Delivery of Neurotrophic Factors in a Silk-based Nerve Conduit for Peripheral Nerve Repair ..........................................................407C. De Carvalho, W. Chang, R. Reis, J. Oliveira, J. Kohn

Graphene-based Flexible Electronics Fabricated via Polymer Casting to Control Stem Cell Differentiation ....................................408M. Uz, K. Jackson, M. Donta, J. Jung, D. Sakaguchi, J. Claussen, S. Mallapragada

Fabrication of Nanofibrous Composite Meshes Incorporating Mg Metal particles for Nerve Repair Applications ..........................409N. Bhattarai, U. Adhikari, X. An, S. Pixley, J. Sankar

ENGINEERED MICROENVIRONMENTS IN HEALTH AND DISEASE 3D Engineered Patient-Derived Xenograft Tumors to Recapitulate the Obese Colorectal Cancer Tumor Microenvironment ..........................................................................................................................................................................................410

I. Hassani, B. Anbiah, B. Ahmed, N. Habbit, M. Greene, E. Lipke

Pulmonary Fibrotic Microtissue Array for Screening Anti-fibrosis Therapy.........................................................................................411R. Zhao, M. Asmani

Engineered Hydrogels to Induce Breast Cancer Dormancy and Reactivation .......................................................................................412J. Slater, S. Pradhan

Microfluidic Gradient Generator for Drug Testing on a Colorectal Tumor-on-a-Chip Disease Model ..............................................413M. Carvalho, D. Barata, L. Teixeira, S. Giselbrecht, R. Reis, M. Oliveira, P. Habibovic, R. Truckenmüller

Cancer Associated Fibroblasts (CAFs) Confer Shear Resistance to Circulating Tumor Cells .............................................................414A. Clinch, N. Ortiz Otero, J. Marshall, M. King

Microfluidic Prostate Tumor-on-a-Chip Model for in vitro Recapitulation of the Tumor Microenvironment ..................................415N. Habbit, B. Anbiah, L. Anderson, J. Suresh, I. Hassani, M. Eggert, S. Jasper, B. Prabhakarpandian, R. Arnold, E. Lipke

Development of a 3D Hydrogel Model of Glioblastoma Invasion .............................................................................................................416L. Smith, L. Bahlmann, L. Zhu, P. Dirks, M. Shoichet

Spatiotemporally Addressable Biomaterial Microenvironments for Modeling Pulmonary Fibrosis in vitro .....................................417C. Magin, T. D'Ovidio, N. Darling

3D BIOPRINTING APPLICATIONS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE Printing Therapeutics in 3D Using Nanoengineered Bioink......................................................................................................................418

A. Gaharwar, C. Peak, J. Chen, M. Adlouni, K. A. Singh

Combinatorial Screening of 3D Printable Bioinks for Cartilage Repair .................................................................................................419J. Galarraga, S. Vega, M. Kwon, J. Burdick

Development of Open Source 3D Bioprinters For Low-Cost and High-Fidelity Biofabrication...........................................................420J. Tashman, S. Sohn, T. Hinton, D. Shiwarski, A. Lee, A. Hudson, A. Feinberg

Engineering Cell Instructive DNA-Nanocomposites for Tissue Engineering, Bio-printing and Regenerative Medicine ..........................................................................................................................................................................................................421

A. Paul, S. Basu, S. Pacelli, J. Wang

3D Bioprinting of Biomimetic Constructs with Spatially Controlled Microenvironment for Rotator Cuff Augmentation..................................................................................................................................................................................................422

B. Duan, P. Streubel, M. Kuss, S. Wu

3D Printing of Microstructured Collagen Scaffolds to Guide 3D Muscle Organization ........................................................................423A. Lee, T. Hinton, A. Hudson, J. Bliley, A. Feinberg

Fast Stereolithographic Printing of Large-scale Vascularized Tissue......................................................................................................424R. Zhao, N. Anandakrishnan, H. Ye, C. Zhou

Tunable Oxygen-Releasing, 3D-printed Scaffolds Improve in vivo Osteogenesis...................................................................................425A. Farris, D. Lambrechts, N. Zhang, A. Rindone, E. Nyberg, A. O'Sullivan, S. Burris, K. Free, W. Grayson

BIOMATERIALS EDUCATION SIG An Exploration of Faculty Perceptions of Tissue Engineering and Regenerative Medicine to Inform Biomedical Engineering Curriculum Development ........................................................................................................................................................426

N. Friend, C. Woodcock, J. Stegemann, A. Huang-Saad

Biomaterials Experiential Learning: Integrating Research and Professional Development .................................................................427K. Burg, T. Burg

BIOMATERIAL-TISSUE INTERACTION SIG Assessment of the Osteopromotive Potential of a Novel Biocompatible Mineral-Organic Adhesive Bone Cement in the Microgravity of Space and on Earth......................................................................................................................................................428

J. Willoughby Sr., M. Brown, R. Jadia, B. Ebendick-Corpus, N. Hibbard, J. McKim, B. Hess

Keratin Nanomaterial Coating Limits Epithelial Downgrowth Around Percutaneous Devices ...........................................................429B. Bennett, S. Jeyapalina, J. Beck, K. Bachus, M. Van Dyke, A. Trent

Engineering Autoclavable and Injectable Hyaluronic Acid-Based Cryogel Scaffolds ...........................................................................430M. Rezaeeyazdi, T. Colombani, S. Bencherif

Using Feature Datasets of Nanoparticle Diffusion to Predict Parameters of the Brain Microenvironment........................................431C. Curtis, M. McKenna, E. Nance

The Effect of Annealing and Surface Texture Of 3D Printed PEEK on MC3T3 E1 Behavior .............................................................432C. Basgul, T. Yu, S. Escobedo, D. Macdonald, M. Marcolongo, S. Kurtz

Characterizing Tissue Deformation and Inflammation Due to Convection Enhanced Delivery in the Brain.....................................433M. Dessi, S. Kodamasimham, C. Wood, J. Sy

Designing Polymers for the Activation of, and Selective Resorption by, Osteoclasts for Bone Regeneration .....................................434S. Fung, D. Martin, A. Mahat, P. Mishra, J. Cohen, E. Pashuck, Y. Mao, P. Moghe, A. Merolli, J. Kohn

Contribution of Scaffold Crosslinking and Pro-inflammatory Signals to Vascularization in vivo.......................................................435A. Clark, K. Spiller

Interactions of Dermal Papilla Spheroid Array and Acellular Skin Dermis During Hair Follicle Regeneration...............................436Y.-Y. Huang, C.-H. Tsai

Increased Nanoparticle Uptake Under Disturbed Flow-Induced Degraded Glycocalyx Conditions ...................................................437N. Bal, M. Cheng, R. Kumar, S. Sridhar, E. Ebong

Cross-linked Electrospun Cartilage Acellular Matrix Film as an Anti-Adhesive Barrier.....................................................................438M. S. Kim, J. Y. Park, S. Park, B. Min

BIOMATERIALS FOR CARDIOVASCULAR REGENERATION Bioprinted Cardiac Patch Composed of Cardiac Progenitor Cells and Extracellular Matrix for Heart Repair and Regeneration ...................................................................................................................................................................................................439

D. Bejleri, B. Streeter, A. Nachlas, M. Brown, R. Gaetani, K. Christman, M. Davis

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic .....................................................................................................................................................................................440

E. Mihalko, K. Huang, E. Sproul, K. Cheng, A. Brown

ROS Scavenging Thermoresponsive Hydrogels Improves Contractility in Ovine Myocardium Adjacent to a Myocardial Infarction ....................................................................................................................................................................................441

Y. Zhu, K. Spaulding, A. Ramasubramanian, A. Badathala, D. Lovett, A. Baker, N. Ziats, K. Healy, M. Ratcliffe, H. Haraldsson

Polyhydroxyalkanoates, Ideal Materials for Cardiac Regeneration ........................................................................................................442I. Roy, P. Dubey, E. Humphrey, Q. Majid, C. Grigsby, M. Stevens, C. Terracciano, S. Harding

Substrate Stiffness Modulates Endothelial-to-Mesenchymal Transition .................................................................................................443N. Huang, M. Zamani, F. Charbonier

Evaluating Pre-vascularized Microtissues in a Mouse Model of Critical Limb Ischemia .....................................................................444N. Friend, J. Beamish, J. Stegemann, A. Putnam

Riboflavin Photocrosslinking Method for Improving Elastin Stability and Reducing Calcification in Bioprosthetic Heart Valves ....................................................................................................................................................................................................445

Y. Lei, W. Jin, G. Guo, M. Liu, Y. Wang

Autologous Vascular Regeneration for Peripheral Artery Disease with Induced Pluripotent Stem Cells ..........................................446B. Jiang, Y. Zhu, X. Wang, N. Rivera Bolanos, C. Duan, X. Zhang, G. Ameer

Hypoxia-sensitive Oxygen Release Microspheres to Improve Cell Survival under Ischemic Conditions ............................................447Y. Guan, N. Gao, H. Niu, Y. Dang, J. Guan

Cardiac Stromal Cell / Platelet-Inspired Nanoparticles for Targeted Heart Repair..............................................................................448T. Su, K. Huang, P.-U. Dinh, J. Cores, Z. Li, S. Hu, Q. Yin, F. Ligler, K. Cheng

An ECM-mimicking Bilayer Vascular Graft from Collagen Filaments and Nanofibers .......................................................................449F. Zhang, S. Bernacki, O. Okkus, M. King

Increasing Cardiomyocyte Alignment Through Micropatterning in the Tension-Culture Composite Cardiac Patch ......................450E. English, G. Pins

Antibody and Synthetic Peptide-Based Smart Targeting of Matrix Regenerative Nanoparticles for Aortal Wall Repair...............................................................................................................................................................................................................451

A. Camardo, A. Ramamurthi

Characteristics Required for Ultra Small-Diameter (0.6mmID) Acellular Blood Vessels: Differences from Small-Diameter (2mmID) Ones................................................................................................................................................................................452

T. Yamaoka, H. Yamanaka

Small Caliber Silk Fibroin Vascular Graft: from Design to in vitro and in vivo Tests ..........................................................................453U. Armato, A. Alessandrino, A. Chiarini, M. Biagiotti, G. Bassani, V. Vincoli, I. Dal Pra, G. Freddi

Injectable Decellularized Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction Model.........................................................................................................................................................454

M. Diaz, R. Gaetani, C. Luo, R. Braden, A. Demaria, K. Christman

Formation of Cardiac Tissues from Encapsulated hiPSCs through LAP-initiated Photocrosslinking ................................................455F. Finklea, G. Bradley, E. Lipke

A Transparent and Long-Lasting Fibrin Hydrogel for Dynamic Cell Culture and Tissue Engineering .............................................456D. Jarrell, E. Vanderslice, M. Lennon, J. Jacot

The Effect of Decellularization Method on Cell Behavior on the Decellularized Aorta.........................................................................457M. Kobayashi, M. Kondo, A. Tamura, Y. Hashimoto, T. Fujisato, T. Kimura, A. Kishida

Increasing Pore Size for Prevascularizing Electrospun Cardiac Patches ................................................................................................458E. Beck, A. Lyons, J. Jacot

Mechano-environment Modulates Matrix Hydrogel Induced Cardiomyocyte Cell Cycle Activity in Cardiac Explants ...........................................................................................................................................................................................................459

X. Wang, S. Senyo

Plasma-modification of PVDF Scaffolds improve Cardiomyocytes Viability and Morphology ...........................................................460M. Kitsara, T. Dufour, V. Humblot, M. Legris, A. Simon, G. Revet, O. Agbulut

Injectable Hydrogel Delivery of Extracellular Vesicles Isolated from Pre-Conditioned Cells to the Heart ........................................461M. Chen, E. Li, A. Gaffey, D. Goldberg, S. Kim, Z. Tran, P. Atluri, J. Burdick

CARDIOVASCULAR BIOMATERIALS AND BLOOD COMPATIBILITY Electrospun Bilayer Fibrous Membranes of Polycaprolactone (PCL)-Collagen/Silica for Small Diameter Vascular Prostheses ........................................................................................................................................................................................................462

S. Park, M. Lee, J. Kim, C. Hwang, H.-E. Kim, T.-S. Jang

Particular Ratios of Blended, Electrospun Scaffolds Impact Molecular Orientation and Reduce Collagen Thrombogenicity.............................................................................................................................................................................................463

K. Washington, P. Dewan, K. Clarke, M. Shojaee, C. Bashur

Synergistic Effects of Functional Additives on the Physico-Mechanical and Biological Properties of Poly(L-lactic acid) Composites for Cardiovascular Implant Applications .....................................................................................................................464

D. K. Han, E. Y. Kang, B. Choi, W. Park, I. H. Kim

Hemocompatibility of Superhydrophobic and Superhydrophilic Surfaces .............................................................................................465R. Maia Sabino, T. Kumar Jammu, H. Vahabi, S. Movafaghi, A. Kota, K. Popat

Plasma Treated TiO2 Nanotubular Surfaces as Stents - Interactions with Biological Materials ..........................................................466M. Bencina, I. Junkar, A. Iglic, K. Lakota, M. Mozetic, S. Sodin-Semrl

In situ Generation of Nitric Oxide from Heparinized Surfaces for Enhanced Cardiovascular Therapy ............................................467D. L. Tran, K. D. Park, P. L. Thi

A Coronary Drug-Eluting Stent Functionalized with Magnesium Hydroxide on Abluminal Layer for Improving Re-endothelialization with a Minimalized Inflammatory Response.........................................................................................................468

W. Park, D.-W. Jeong, D. K. Han

Thrombogenicity of Poly(vinyl) Alcohol Hydrogels is Dependent on the Crosslinking Agent ..............................................................469N. Bates, C. Puy, O. McCarty, M. Hinds

CARDIOVASCULAR BIOMATERIALS SIG Characterizing the Long Term Inflammatory Response to Zinc Stent Materials ..................................................................................470

A. Oliver, E. Earley, R. Guillory II, J. Drelich, J. Goldman

Corrosion Behavior of HF-treated Mg Alloy Scaffold After Expansion ..................................................................................................471X. Wei, Y. Kai, K. Yuki, S. Makoto, N. Takuro

Zn2+ Release from Intravascular Metallic Zinc Implants Promote Smooth Muscle Cells Apoptosis ...................................................472R. Guillory II, J. Goldman

A Paradigm-Shifting Stent Technology: Liquid Cast Arterial Stents ......................................................................................................473W. He, H. Kassam, M. Klein, N. Tsihlis, M. Kibbe

Long Term Biocompatibility of Zn and Zn Alloys in a Murine Arterial Model .....................................................................................474E. Earley, R. Guillory II, A. Oliver, J. Goldman, J. Drelich

Vessel Graft Fabricated by the Onsite Differentiation of Mesenchymal Stem Cells in the Vascular Extracellular Matrix Scaffold Under Mechanical Stimulation in Bioreactor .................................................................................................................475

Z. Hong, N. Li

Inexpensive Method for Measuring Mechanical Properties of Polymeric Biomaterials ........................................................................476S. Tasmim, N. Bodiford, J. Coffer, T. Tayag

Hydrogels with Self-healing Abilities As Injectable Carriers for Vasculogenesis...................................................................................477Z. Wei, S. Gerecht

A Biodegradable Knitted Heart Cap for the Delivery of Cardiosphere-Derived Cells (CDCs) to Induce Reverse Remodeling of a Failing Left Ventricle ........................................................................................................................................................478

J. Chen, K. Cheng, A. West, M. Daneshmand, M. King

Fibrotic and Calcific Roles of TNF-a on Valvular Interstitial Cells Encapsulated within 3D MMP-degradable Hydrogels.........................................................................................................................................................................................................479

A. Gonzalez Rodriguez, M. Schroeder, K. Anseth

Examining the Signaling Pathways Connecting Endothelial-Mesenchymal Transition (EndMT) and Smooth Muscle Cells in Vascular Calcification.........................................................................................................................................................480

C. Travis, C. Roach, C. L. Simpson

Design and Development of Stent Coated with Novel Cardiac Stem Cell-mimicking Regenerative Factors ......................................481M. King, T. Bambharoliya, S. Hu, K. Cheng

DENTAL/CRANIOFACIAL BIOMATERIALS SIG Si3N4 or UHMWPE a Potential Material for Fabricating TMJ Condylar Prosthesis? .........................................................................482

S. K. Mamidi, M. T Mathew, V. A R Barao, N. Gurram, L. G. Mercurie

A Pilot Study on the Structural Role of Water in Dental Tissues .............................................................................................................483E. Sobiesk, J. Livingston, Y. Duan, S. Yang

Relaxin as an Enhancer of BMP-2 Loaded Hydroxyapatite Microspheres in Bone Regeneration.......................................................484Y.-W. Huang, S. Injamuri, M. Rahaman, Y. Shen

Mineralized Short Nanofibers Coupled with BMP-2 Peptides for Alveolar Bone Regeneration..........................................................485J. Xie, H. Wang, S. Boda, D. Wang, R. Reinhardt

Determination of Phase Evolution of a Novel Mineral-Organic Bone Adhesive in vivo and in vitro ...................................................486R. Jadia, G. Kay, M. Brown, C. Cavaleri, R. Shea, B. Hess

Enhancing Vital Bone Growth With Growth Enhancers - L-PRF and Calcium Sulfate .......................................................................487R. Horowitz

Bioactive Materials for Dentoalveolar Reconstruction and Regeneration...............................................................................................490R. Horowitz

PART 2

Color Changes of Resins Applied in the Fabrication of 3D-Printed Orthodontic Brackets ..................................................................493

F. Kasper, A. Haynie, M. Abu Al Tamn, J. English, R. Paravina

Highly Efficient Labeling of Mesenchymal Stem Cells with Superparamagnetic MRI probes in Magnetic Field .............................494J. Duan, R. Jin, L. Liu, L. Yang, H. Ai

Silicon-Containing Shape Memory Polymer (SMP) Scaffolds for Cranial Bone Defect Repair ...........................................................495F. Beltran, M. Grunlan, C. Houk

Synthetic Morphogen Fields for Directed Dental Pulp Stem Cell Differentiation ..................................................................................496S. Rahman, M. Nagrath, S. Ponnusamy, P. Arany

Functionalization of Dental Prosthetic Interfaces Following Adaption of Dental Materials for 3D Printing .....................................497A. Sikora, M. Nagrath, J. Graca, S. Ur Rahman, P. Arany

Smart Dental Fillings with Ruthenium Nanoparticles-enhanced Photobiomodulation Therapy for Pulp-Dentin Regeneration ...................................................................................................................................................................................................498

N. Young, R. Mosca, P. Arany, C. Zeituni

GUIDED TISSUE REGENERATION A Modular Host-Gust Approach to Build up Glycopolymers for Cell Surface Engineering ................................................................499

Y. Gu, B. Liu, G. Chen, H. Chen

Electrospun Chitosan Guided Bone Regeneration Membranes for Delivery of Simvastatin to Stimulate Osteogenesis ....................................................................................................................................................................................................500

V. P. Murali, F. Guerra, T. Fujiwara, J. Bumgardner

Electrospun Chitosan Membranes Loaded with Raspberry Ketone for Guided Bone Regeneration Applications ...........................501P. Cameron, V. Murali, F. Delbuque Guerra, J. Bumgardner

Effect of a Polymer/Ceramic Membrane Associated with Mesenchymal Stem Cells on Bone Repair in Osteoporotic Rats...................................................................................................................................................................................................................502

A. Souza, A. Almeida, G. Freitas, H. Lopes, R. Gimenes, S. Siessere, L. Sousa, M. Beloti, A. Rosa

BIOMATERIALS FOR THERAPEUTIC DRUG DELIVERY Macrophage-Targeted Antibacterial Polymeric Prodrug for Controlled Drug Pharmacokinetics Against Alveolar Pulmonary Intracellular Infections ..............................................................................................................................................................503

D. Roy, F.-Y. Su, S. Srinivasan, B. Lee, T. West, D. Ratner, S. Skerrett, P. Stayton

Glomerular Disease Augments Kidney Accumulation of Synthetic Anionic Polymers..........................................................................504A. Prossnitz, G. Liu, D. Eng, Y. Cheng, J. Pippin, R. Lamm, C. Ngambenjawong, R. Jain, S. Shankland, S. Pun

Drug-Refillable In Situ Forming Implants for Recurrent Tumor Chemotherapy .................................................................................505A. Dogan, K. Young, H. Von Recum

Rm-loaded Polymeric Micelles Reduces Secondary Injury in a Rat TBI Model ....................................................................................506C. Macks, D. Jeong, M. Lynn, J. Lee

N-Oxalylglycine-Conjugated Hyaluronic Acid Stimulates Angiogenic Gene Expression ......................................................................507A. Demaria, K. Webb, J. S. Lee

Promotion of Accelerated Healing in a Mouse Wound Model with a Viral Immunomodulator Serp-1/chitosan Gel .......................508L. Zhang, J. Yaron, S. Wallace, M. Burgin, A. Tafoya, A. Lucas

Targeted Drug Delivery via Cell-Nanoparticle Hybridization for Enhanced Efficacy and Reduced Off-Target Toxicity ............................................................................................................................................................................................................509

R. Cooper, J. Wang, H. Yang

Localized Tacrolimus Delivery for Transplant Rejection Prevention via TyroSphere-loaded Rapidly Soluble Films ......................510J. Molde, A. Merolli, J. Steele, M. Lima, S. Pratts, A. Lellouch, C. Cetrulo Jr., J. Kohn

Antibiotic Extended Release Concentration Quantification By Semi-empirical Model For Insulin Delivery Catheters..........................................................................................................................................................................................................511

J. King, B. Ratner

Anti-VEGF Delivery from Alginate – Chitosan Polyelectrolyte Complexes Decreases Bony Bar Formation in Physeal Injuries ..............................................................................................................................................................................................512

J. Newsom, C. Erickson, N. Fletcher, Z. Feuer, Y. Yu, F. Fontan, N. Miller, K. Payne, M. Krebs

Hollow Microshell Through Layer-by-Layer Self-Assembly of Natural Polyelectrolytes on E. coli ....................................................513M. Yitayew, M. Tabrizian

Polyzwitterion Coated Peptide Dendritic Carbon Dots for Efficient Chemotherapy.............................................................................514Q. Yi, J. Ma, Z. Gu

Development of Coacervates Using mPEGylated Poly(Ethylene Arginylaspartate Diglyceride) Cationic Polymer for Protein Delivery ........................................................................................................................................................................................515

H. Jo, G. Mani, K. Kim

Implantable Peptide-Hydrogel Drug Delivery System for Treating Glioblastoma Multiforme............................................................516M. Elpers, A. Gregory, E. Miller, A. Alexander-Bryant

Sustained-released Platelet-Rich Plasma from Polyethylene Glycol Hydrogels Exerts Beneficial Effects on Chondrocytes ..................................................................................................................................................................................................517

A. Blanco, E. Jain, N. Chinzei, N. Case, S. Sell, M. Rai, S. Zustiak

3D Printed Degradable Microneedles for Controlled Drug Release in the Nervous System .................................................................518M. Walter, J. Johnson, R. Saigal

Sustained-Release Depots for HIV PrEP .....................................................................................................................................................519C. Leguyader, D. Roy, S. Srinivasan, P. Stayton

Polymeric Nanoparticles for Controlled and Systemic Delivery of an Anti-Cancer Chelator ..............................................................520C. Holley, S. Majd

Fluorescence Correlation Spectroscopy for the Measurement and Prediction of Drug Release from Degradable Hydrogels.........................................................................................................................................................................................................521

S. Sheth, E. Barnard, M. Rathinam, S. Zustiak

PLGA-Encapsulated Nanoceria and SOD as a Deliverable, Antioxidative Therapy .............................................................................522A. Mehta, B. Scammon, D. Ashley, B. Stewart, K. Jardim, K. Shrake, M. Bredikhin, V. Ivanov, V. Reukov

In situ Ethanol Depot Enhances Tumor Necrosis and Immune Activity in Breast Tumors ..................................................................523C. Nief, R. Morhard, B. Crouch, N. Ramanujam

pH-sensitive Liposomes as Drug Carriers for the Treatment of Brain Infection Diseases ....................................................................524C. Bartomeu Garcia, D. Shi, T. Webster

Target-switchable Modular Bacterial Toxin Delivery System ..................................................................................................................525S. Park, B. Choi, Y. Bae, S. Kang

Accelerated Arteriogenesis and Vessel Branching Using Dll4/VEGF Delivery System .........................................................................526H. Niu, N. Gao, Y. Dang, Y. Guan, J. Guan

Local Delivery of Hepatocyte Growth Factor Reduces Glial and Fibrotic Scar Formation After Spinal Cord Injury .....................527Y. Zhong, Z. Wang, M. Yang, J. Nong, R. Shultz, Y. Zhao, S. Hou

ROS-responsive Drug Carriers for Intracellular Delivery of Pro-Oxidant Drugs .................................................................................528M. S. Shim, Y.-S. Kim, S. Kim, D. G. Choi

Liquid Filled Multilayered Capsules for Oral Delivery .............................................................................................................................529Y. Kim, J. Kim, Y. Kim, J.-H. Jang

Targeted Delivery of Nanoparticles as a Treatment for Emphysema ......................................................................................................530V. Parasaram, X. Wang, N. Vyavahare

Engineering Poly(lactic-co-glycolic) Acid Nanoparticles to Target the Inflamed Peripheral Nerve ....................................................531K. Langert, E. Brey

Sustained Release Silk Foams for the Local Delivery of Monoclonal Antibodies ...................................................................................532B. Yavuz, K. Harrington, B. Perez-Ramirez, P. Liwang, D. Kaplan

Folate-PEG Modified Liposome Using Amphiphilic Doxorubicin for Tumor Targeting ......................................................................533J.-S. Choi, B.-K. Kim, J.-W. Park, D.-B. Jeong, Y.-B. Seu, J.-H. Nam, K.-O. Doh

Remodelling of the Protein Corona on Long Circulating Single Molecule Soft Polymer Nanoparticles in vivo.................................534L. Takeuchi, S. Abbina, A. Parambath, K. Yu, J. Kizhakkedathu

Ultrasound Mediated Release from Three Targeted Liposomes (Human Serum Albumin, Transferrin and RGD) .........................535G. Husseini, N. Awad, V. Paul, M. Mahmoud, N. Alsawaftah, P. Kawak, M. Al Sayah

Injectable Polyester Hydrogel-mediated Myeloid-derived Growth Factor Delivery for Improved Post Myocardial Infarction Heart Healing ...............................................................................................................................................................................536

Z. Li, X. Xu

Improved Micellar Nanoparticle Stabilization............................................................................................................................................537E. Green, H. Acar

The Efficiency of Cytosolic Delivery using pH-Responsive Endosomolytic Polymers does not Correlate with Activation of the NLRP3 Inflammasome .....................................................................................................................................................538

J. Baljon, A. Dandy, L. Wang-Bishop, M. Wehbe, M. Jacobson, J. Wilson

Design of a Dendrimeric Nanomedicine Platform for the Treatment of a Neuro-Degenerative Disease, X-ALD ..............................539O. Gok, C. Nemeth, K. Rangaramanujam, B. Turk, S. Kambhampati, F. Zhang, A. Sharma, S. Kannan, A. Fatemi

Magnetic Nanogel Delivery of Transcription Factor to Adipose-derived Stem Cell for Muscle Tissue Regeneration.......................540N. Kinoshita, Y. Sasaki, R. Kawasaki, E. Marukawa, H. Harada, K. Akiyoshi

Supramolecular PEGylation as an Innovative Approach to Biopharmaceutical Formulation and Delivery......................................541C. Maikawa, A. Smith, E. Appel

Implementing siRNA-Based Therapy of Chronic Myeloid Leukemia Ex Vivo by using Lipopolymeric Carriers............................542H. Uludag, J. Valencia-Serna, C. Kucharski, M. Chen, R. K. C., J. Brandwein, X. Jiang

Development of Magnetic Micelles As Anti-inflammation Drug Carrier for Coronary Atherosclerotic Treatment .........................543T.-R. Ger, Y.-C. Huang, C.-M. Su, T.-Y. Chen, F. Dong, C.-K. Tsou

RAGE Targeting Therapeutic Exosome for Drug Delivery ......................................................................................................................544G. Kim, M. Lee

Dual Aptamer-functionalized In Situ Injectable Fibrin Hydrogel for Promotion of Angiogenesis via Co-delivery of Growth Factors ...............................................................................................................................................................................................545

N. Zhao, A. Suzuki, X. Zhang, Y. Wang

Basic Amino Acids Modified Poly(amidoamine) Generation 2 for Delivery of Plasmid DNA ..............................................................546Y. K. Lee, L. T. Thuy, J. S. Choi, M. Lee

Using Machine Learning to Predict the Binding Dissociation of FDA Approved Drugs for Affinity-Based Drug Delivery Applications .....................................................................................................................................................................................547

E. Rivera Delgado, A. Xin, H. Von Recum

DRUG DELIVERY SIG Microneedle-Assisted Topical Drug Delivery for Combination Therapy of Deep-Seated Melanoma ..................................................548

Y. Zhao, H. P. Tham, T. G. S. Thng, S. Venkatraman, C. Xu

Blurring the Line Between Device and Drug by Targeting the Fibrin Blood Clot Niche ......................................................................549N. White, X. Wang, R. Lamm, L. Chan, S. Pun, Y. S. Wong, S. Venkatraman

The Effect of Halloysite Addition on Chitosan/HNTs Hydrogel Composites Material Properties .......................................................550Y. Luo, D. Mills

Investigation of Diclofenac Sodium Release from Electrospun Composite Nanofibers of Poly (ε-caprolactone) and Chitosan ...........................................................................................................................................................................................................551

S. Saudi, U. Adhikari, S. Aravamudhan, J. Sankar, N. Bhattarai

3D Printed Calcium Deficient Hydroxyapatite/Collagen/Platelet Rich Plasma Composite Scaffolds Functionalized with Sustained Release of Growth Factor for Bone Tissue Regeneration................................................................................................552

J. Lee, S. J. Chae, W. Kim, J. Lee, M. Yeo, G. H. Yang, H. Kim, Y. Choe, Y. Koo, G. Kim

Stem Cells-Derived Nano-Vesicles for Augmented Regenerative Repair of Vascular Elastic Matrix .................................................553S. Sajeesh, A. Ramamurthi

A Tumor-Specific Amplification of Oxidative Stress with Triggered Drug Release Nanoparticle for Cancer Therapy............................................................................................................................................................................................................554

L. Yang, W. Zhuang, G. Li, Y. Wang

Two-Photon AIE Probe Conjugated Theranostic Nanoparticles for Tumor Bioimaging and pH-Sensitive Drug Delivery ............................................................................................................................................................................................................555

G. Li, B. Ma, W. Zhuang, Y. Wang

Redox and pH Dual-Responsive Polymeric Micelle with Aggregation-Induced Emission Feature for Cellular Imaging and Chemotherapy..........................................................................................................................................................................557

W. Zhuang, L. Yang, G. Li, Y. Bing

Hyaluronic Acid-coated Gold Nanorods Enhancing Multivalent BMP2 Peptide Delivery for Chondrogenesis.................................558K. Sansanaphongpricha, P. Sonthithai, P. Kaewkong, S. Bamrungsap, W. Kosorn, N. Saengkrit

Antisense Oligonucleotides Delivery with Bioreducible Lipid-based Nanoparticles in vitro and in vivo ............................................559L. Yang, Q. Xu

Fine-tuning Lung Cancer Nanotherapy Using Closed Cardiopulmonary Circulation ..........................................................................560D. Bölükbas, C. Morrone, A. Doryab, S. Datz, D. Gössl, S. Van Rijt, T. Stöger, T. Bein, S. Meiners, D. Wagner

Engineering Anti-Cancer Extracellular Vesicles via Lipid Hybridization and Layer-by-Layer Approaches ....................................561Y.-Y. Jhan, G. Palou Zuniga, C. Bishop

Targeted Delivery of Kartogenin-Encapsulated Nanoparticles for Improved Uptake by Mesenchymal Stem Cells .........................562B. Almeida, Y. Wang, A. Shukla

Cellulose-based Biopolymers for Controlled Drug Delivery: A Mechanistic Investigation...................................................................563K. Odonnell, N. Comolli, G. Oporto

Multilayered Drug Delivery Sheet that Allows Minimally Invasive Delivery to the Eye .......................................................................564H. Kaji, Y. Sato, N. Nagai, T. Abe

Electrospun Pullulan Based Nanofibers for Medical Applications...........................................................................................................565A. Bossart, S. Shady, D. Kalyon

Single Injection Delivery System for Sabin Inactivated Polio Vaccine ....................................................................................................566X. Lu, K. McHugh, Z. Tochka, S. Rose, M. Taylor, T. Graf, E. Budina, R. Langer, A. Jaklenec

Targeted Drug Delivery System Using Core/Shell microgels Containing Magnetic Nanoparticles and conjugated with Specific Ligands .....................................................................................................................................................................................567

A. Jo, J. Yoon, J. W. Chung

Photo-crosslinked GelMA Hydrogel as Drug Carriers to Locally Applicate Abaloparatide in Promoting Bone Defect Regeneration .......................................................................................................................................................................................568

Z. Ning, W. Lu, B. Tan

Guided Bone Regeneration (GBR) Membrane with Embedded Hydroxyapatite (HA) Pattern for Drug Loading ...........................570I.-G. Kang, Y.-J. Seong, E.-H. Song, J.-Y. Kim, H.-E. Kim, C.-M. Han

DNA Delivery to Cells by Ultrabithorax Protein-Based Materials...........................................................................................................571R. Booth, K. Churion, A. Alvarez, S. Ramasamy, S. Bondos

NON-VIRAL DELIVERY FOR GENE THERAPY AND EDITING Blood Compatibility and Biodistribution of Various Therapeutic Nucleic Acid (TNA) polyplexes .....................................................572

K.-T. Kim, J. Halman, C. Macks, K. Afonin, J. S. Lee

IL-21 Vector-tethering Nanofibers for Cancer Treatment Including Osteosarcoma.............................................................................573S.-Y. Yang, X. Gong, J. Jiang, M. Ceylan, B. Dart, R. Asmatulu

Improving Poly(amidoamine) Dendrimer Gene Delivery via Physical Interaction with a Nuclear Localization Sequence Peptide ............................................................................................................................................................................................574

R. Cooper, H. Yang

A Universal Intracellular Delivery and Cell Releasing System via the Photoporation of Polydopamine and the Thermal-Responsiveness of Poly(N-isopropylacrylamide) ........................................................................................................................575

J. Wu, Q. Yu, H. Chen

Novel, Biodegradable, Sugar-based Gene Carriers for Cancer Therapy ................................................................................................576S. Hong, M. Ahn, R. Arote

Cationic Lipopolymers: Simple, Versatile Carriers for Gene Delivery....................................................................................................578H. Uludag, K. C. Remant, B. Thapa

Asialoglycoprotein Receptor Targeted Sugar-alcohol Derivatives As Gene Carriers for Cancer Treatment.....................................579M. Ahn, S. Hong, R. Arote

Nucleobase-Modified Polyamidoamine-Mediated miR-23b Delivery to Inhibit the Proliferation and Migration of Lung Cancer....................................................................................................................................................................................................581

H. Han, Q. Li

SYNTHETIC NANOMATERIALS FOR THERAPEUTIC DELIVERY Biodegradable Nanoparticles for Enhanced Lymph Node Trafficking and Paracortex Penetration for Malaria Transmission Blocking Vaccines...................................................................................................................................................................582

G. Howard, G. Verma, P. Khare, X. Ke, R. Dinglasan, H.-Q. Mao

Selective Protection of Proteins in Polymeric Biomaterials to Understand the Effect of Gastrointestinal Digestion on Oral Tolerance...........................................................................................................................................................................................583

H. Frizzell, K. Woodrow

Enhancing the Stability and Potency of the Adjuvant Poly(I:C) through Nanoparticle Encapsulation ..............................................584E. Gale, G. Agmon, A. Smith, E. Appel, C. Maikawa, E. Appel

The Establishment of a 4T1 Breast Cancer Model for TRAIL Immunotherapy Studies ......................................................................585J. Dombroski, N. Jyotsana, Z. Zhang, M. King

Engineered Polymeric Micelles for Combinational Oxidation Anticancer Therapy Through Concurrent HO-1 Inhibition and ROS Generation....................................................................................................................................................................586

H. Hyun, E. Jung, S. Hong, D. Lee

Intravenous Application of Bispecific Antibody for Cardiac Regenerative Therapy After Heart Ischemia/Reperfusion Injury ........................................................................................................................................................................587

K. Huang, Z. Li, T. Su, S. Hu, K. Cheng

Internalization of Folate Receptor Targeting Nanoparticles into Ovarian Cancer Cell Lines..............................................................589H. Acar, K. Haddad, T. Le

Effect of Heparin-Coated Magnetic Nanoparticles on Human Vascular Cells .......................................................................................590N. Ghobrial, B. Fellows, O. Mefford, D. Dean

Combinational Effects of EPR, Folate Targeting and Shapes for Cancer Theranostic Nanocarriers .................................................591A. Rad, W. Aresh, M.-P. Nieh, P.-S. Lai

Superparamagnetic Iron Oxide Nanoparticles Functionalized with Aggregation-Induced Emission Materials for Dual-Modal Fluorescence/MRI Imaging .....................................................................................................................................................592

S. Fu, R. Jin, Z. Cai, H. Ai

BIOMATERIAL TECHNOLOGIES FOR HEMOSTASIS AND WOUND CARE A Hydrogel-based Smart Bandage for Wound Monitoring and Treatment............................................................................................593

M. Akbari, B. Mirani, E. Pagan, A. Ghahary

Silk-ECM Composite 3D Printed Constructs for Burn Wound Healing .................................................................................................594D. Chouhan, B. Mandal

Enhanced Angiogenesis with Nitric Oxide Releasing Chitosan-PVA Hydrogel for Wound Healing ...................................................595A. Hasan, A. A. Zahid, R. Ahmed, R. U. R. Syed, R. Augustine

Coacervate-mediated Exogenous Growth Factor Delivery for Scarless Skin Regeneration .................................................................596U. Park, M. S. Lee, H. S. Yang, K. Kim

Human-based Nanocomposite Cryogels for Hemostatic and Wound Healing Applications .................................................................597B. Mendes, M. Gómez-Florit, L. Randall, P. Babo, R. Almeida, M. Detamore, R. Domingues, R. Reis, M. Gomes

Melanogenesis Potential of EGF-Loaded Nano-Pillared Chitosan-Gelatin Films ..................................................................................598S. Altuntas, H. Dhaliwal, A. Eid Radwan, F. Buyukserin, M. Amiji

Antimicrobial Hydrogel Foam Dressings for Improved Chronic Wound Healing .................................................................................600Z. Lan, R. Kar, J. Yoon, T. Wilems, T. Buie, C. Whitfield, N. Cohen, E. Cosgriff-Hernandez

Hydrogen Bonding-Driven Self-coacervation of Mussel Foot Protein Mimics (MPMs) as Wet Biological Tissue Adhesives .........................................................................................................................................................................................................601

P. Zhao, B. Yang, L. Bian

Developing a Knitted, Antibacterial Wound Dressing Contact Layer for Infection Management.......................................................602E. Gianino, D. Pham, J. Gilmore

Designing an Antimicrobial Knitted Wound Dressing for Vacuum Assisted Wound Closure..............................................................603D. Zha, P. Nakod, A. El-Shafei, M. King, T. He, A. Brown, S. Hudson

Fabrication of Photocurable Hemostatic Agent with Wound Healing and Rapid Hemostatic Effect ..................................................604C. H. Park, Y. J. Lee, S. H. Kim, M. T. Sultan, O. J. Lee, H. S. Park

Reduced Graphene Oxide Impregnated GelMA hydrogel Promotes Angiogenic Activity in Chick Embryo Model .........................605A. Hasan, S. Rehman, R. Augustine, A. A. Zahid, R. Ahmed

Gelatin-Graphene Oxide Aerogels Loaded with Natural Extracts for Hemostatic Applications .........................................................606S. Guajardo, T. Figueroa, J. Borges, M. Meléndrez, K. Fernández

Human MSCs Delivery Via Extracellular Matrix-embedded Hydrogel Patch for Skin Wound Repair .............................................607K. Park, J. H. Lee, S. S. Ha

Integrating Plant Structures and Systems for Wound Healing: Decellularized Spinach Leaves as a Multifunctional Platform for Tissue Engineered Skin ...........................................................................................................................................................608

E. English, J. Gershlak, D. Dolivo, J. Goverman, G. Gaudette, T. Dominko, G. Pins

Artificial Skin Characterization Using Galvanic Skin Response Data.....................................................................................................609T. P. Ashok, U. Pamidigantam, S. Sadhu, A. Shrirao

BIOMATERIALS TECHNOLOGIES FOR PRECISION MEDICINE Tissue-on-a-Chip Platform for Mesenchymal Stem Cell Potency.............................................................................................................610

R. Schneider, E. K. Williams, J. García, R. Mannino, W. Lam, A. García

Gelatin-based Thiol/Disulfide Degradable Hydrogels to Encapsulate Cells ............................................................................................611J. Serrano, A. Gilchrist, B. Harley, A. García

Identification of IL-27 as Potent Regulator of Osteolysis Triggered by of Orthopaedic Implants Debris...........................................612D. Takahashi, M. A. Terkawi, G. Matsumae, Y. Tian, H. Alhasan, N. Iwasaki

Analysis of Ultrasound Sensitive Polyurethane-Glass Composites...........................................................................................................613J. Contreras, A. Stimpson, I. Ahmed, D. Irvine, A. Whittington

Engineered Biomaterials for Neural Applications Porous Hydrogels for Neural Implants: Effect of Pore Size on Glial Encapsulation .............................................................................614

I. Dryg, L. Crawford, S. Perlmutter, J. Bryers, B. Ratner

Comparison of Hydrogel Encasement Strategies for Implantable Micro-Tissue Engineered Nerve Grafts .......................................615J. Burrell, S. Das, K. Katiyar, F. Laimo, Z. Ali, D. K. Cullen

Engineered Dopaminergic Axonal Tracts within a Tubular Hydrogel Encasement for Living Deep Brain Stimulation in Parkinson’s Disease ..............................................................................................................................................................616

W. Gordián Vélez, L. Struzyna, K. Browne, J. Burrell, J. Wolf, J. Duda, H. I. Chen, D. K. Cullen

Self-Assembled Aligned Glial Cells as "Living Scaffold" for Nervous System Repair ..........................................................................617J. Burrell, J. O'Donnell, K. Panzer, K. Helm, K. Katiyar, K. Browne, W. Gordian-Velez, D. K. Cullen

A Surgical Approach for Spinal Cord Regeneration Based on a 3d Printable Device Able to Provide a Defined Protective Environment .................................................................................................................................................................................618

A. Merolli, B. Varghese, Y. Mao, J. Kohn

Effects of Microarchitecture on Schwann Cell Migration and Proliferation in Magnetically Templated Hydrogels in vitro..............................................................................................................................................................................................................619

I. Singh, M. Kasper, C. Lacko, C. Schmidt, C. Rinaldi

Development of an in vitro Traumatic Brain Injury Model Using 3D Cultured Neural Stem Cells and 3D Printed Device ...............................................................................................................................................................................................................620

W. Shi, M. Kuss, P. Dong, L. Gu, H. J. Kim, B. Duan

A Sequential Double Non-Flourescent Immunostaining for the Easy Identification of the Motor Component in the in vivo Study of Biomaterials for Peripheral Nerve Regeneration ...........................................................................................................621

A. Merolli, P. Louro, J. Kohn

The Fabrication of Melanin Containing Electrospun Scaffolds for Neural Cell Applications ..............................................................622N. Iwakoshi, V. Krivoruk, J. McKenzie, B. Snow

PLA-HPG Nanoparticles as a Therapeutic Carrier for Spinal Cord in Adult Mice ..............................................................................623M. Khang, A. Lynn, H. W. Suh, Y. E. Seo, R. Bindra, M. Saltzman

A Novel Bioactive System Based on Surface-functionalized Plasmonic Nanosystems for Tunable Biological Surfaces............................................................................................................................................................................................................624

K. Alghazali, S. Newby, Z. Nima, R. Hamzah, F. Watanabe, T. Masi, S. Stephenson, D. Anderson, M. Dhar, A. Biris

Effect of Microbial Metabolites on in vitro Enteric Nervous System Tissue Model ...............................................................................625E. Manousiouthakis, N. Alden, M. Dente, O. Hofheinz, K. Lee, D. Kaplan

Self-assembled Human Induced Pluripotent Stem Cell-derived Brain Organoids on PEG Hydrogels for Modeling Melanoma Metastasis .....................................................................................................................................................................................626

E. Aisenbrey, E. Torr, V. Harms, W. Murphy

ENGINEERED MICROENVIRONMENTS IN HEALTH AND DISEASE Developing a Spatially-Defined Biomaterial Model of the Glioblastoma Perivascular Niche ...............................................................627

C. Hunter, M. Ngo, B. Harley

Development of the CellWell™ - A Novel Micropatterned Biphasic Nanocomposite Platform for Chondrocyte Cell Culture .............................................................................................................................................................................................................628

R. Saraswat, W. Schutz, Z. Zhu, P. Ahrenkiel, S. Wood

Versatile Core-Shell Microgels for Cell Encapsulation in Three-Dimensional Cell Culture.................................................................629H. Chen, L. P. Tan

An in vitro Disease Model for Aggressive Hodgkin's Lymphoma ............................................................................................................630L. Bahlmann, M. Shoichet, A. Baker, R. Laister

Controlling Fibrosis Stage of iPS-derived Myocardial Models by Micro-Scaffold Technique .............................................................631M. Matsusaki, K. Nishi, J.-K. Lee, S. Miyagawa, Y. Sawa

Chondrogenesis of Mesenchymal Stromal Cells Modulated by Cell-Cell and Cell-Matrix Interactions .............................................632Y. Xiao, Y. Wang, D. Huang, X. Zhang

Studying the Effects of Pro-inflammatory Cytokines on Breast Cancer Metastasis in a Three-Dimensional Model.........................633M. Williams, J. Alsaleh, C. Gomillion

Printable Cell Culture Platform ...................................................................................................................................................................634D. Soto Veliz, M. Toivakka

Engineering the in vitro Microenvironment of Human Schwann Cells by Providing Electrical Firing Artificial Axons................................................................................................................................................................................................................635

A. Merolli, Y. Mao, G. Voronin, J. Am. Steele, J. Kohn

Engineering A Biomimetic Environment To Pre-Condition Stem Cells For Efficacious Cardiovascular Repair ..............................636A. Raghavachar Chakravarti, S. Pacelli, S. Bagchi, P. Alam, S. Modaresi, A. Czirock, R. P. H. Ahmed, A. Paul

Fabrication of 3D Lymph Node Mimetic and Its Potential for Cancer Diagnosis ..................................................................................637A. Hakamivala, J.-T. Hsieh, L. Tang

Hyperosmolar Potassium Depolarization Suppresses Pro-inflammatory Macrophage Activation ......................................................638H. Chen, J. Enrdt-Marino, M. Hahn

Fibrotic Cytokine TGF-B1 Increases Pericyte Migration in a 3-D Microvascular Model.....................................................................639T. Chung, A. Pellowe, A. Gonzalez

Targeting Adult Stem Cell-Derived Smooth Muscle Cells to the Aortal Wall for Augmented ECM Repair......................................640S. Dahal, A. Ramamurthi

Engineered Nanoclay Based Bone-Mimetic 3D in vitro Test-Bed for Bone Metastasis of Breast Cancer ...........................................641S. Kar, K. Katti, D. Katti

Engineering Hydrogel Based Cancer Microenvironments for in Vitro Breast Cancer Cell Culture and Therapeutics Screening..................................................................................................................................................................................642

W. Shi, M. Kuss, B. Mohapatra, S. Mirza, H. Band, V. Band, B. Duan

Porous Chitosan-Chondroitin Sulfate Scaffolds To Mimic The Prostate Cancer Microenvironment .................................................643K. Xu, S. Florczyk, Z. Wang, J. Copland, R. Chakrabarti, K. Ganapathy

A Microfluidic Platform to Generate 3D in vitro Blood Vessels for the Study of Biofilm Dispersion ..................................................644J. Li, V. Trantow, B. Pernsteiner, A. Mandepally, X. He

Investigation into Soft Tissue Micro-Tearing and Repair Mechanisms as it Relates to Sports Injuries..............................................645A. Seilkop, M. Maggio, M. Judge, O. Newkirk, D. Dean, K. Lindsey, A. Santore, M. Hermanns, E. Caruso

Effect of Low Intensity Ultrasound on the Differentiation of Liver Cancer Stem-like Cells.................................................................646I-Chi Lee, S. Fadera, H.-L. Liu

Inhibition of Extratumoral Chondroitin Sulfate Glycosaminoglycans Stems Glioma Cell Invasion ...................................................647M. Logun, G. Simchick, W. Zhao, L. Mao, Q. Zhao, S. Mukherjee, D. Brat, L. Karumbaiah

Tumor Invasion through Hyaluronic Acid Matrices is Mediated by CD44-Dependent Microtentacles ..............................................648K. Wolf, S. Kenny, S. Lee, P. Shukla, C. Choy, K. Xu, S. Kumar

Hypoxia and Matrix Viscoelasticity Sequentially Regulate Endothelial Progenitor Cluster-Based Vasculogenesis ..........................649M. Blatchley, F. Hall, S. Wang, H. Pruitt, S. Gerecht

A Decoupled Multi-Stimulus Bioreactor for Studying Complex Chemo-Mechanical Microenvironments In Vitro..........................650B. James, N. Montoya, W. Ruddick, J. Allen

ENGINEERING CELLS AND THEIR MICROENVIRONMENTS SIG A Chem-Bio Approach for Stable Display of Synthetic Glycopolymers on Cell Surfaces .....................................................................651

Q. Liu, G. Chen, H. Chen

Patient Derived Glioblastoma Cells Activate Microglia in a Three-Dimensional Gelatin Hydrogel ....................................................652J. W. Chen, J. Lumibao, H. R. Gaskins, B. Harley

Hypoxia-Inducing Cryogels for Preclinical Anticancer Drug Screening .................................................................................................653T. Colombani, J. Sinoimeri, S. Bencherif

Morphological Adaptations in Breast Cancer Cells as a Function of Prolonged Passaging on Compliant Substrates ......................654S. Syed, A. Blanco, J. Schober, S. Zustiak

Bioengineered 3D Interpenetrating Collagen-Alginate Network to Examine the Effects of Matrix-Mechanics on Cancer-associated Fibroblasts (CAFs) Behaviour ......................................................................................................................................655

H. Cao, M. Lee, H. Yang, S. Sze, N. Tan, C. Tay

Using Hydrogel Composite Models to Study Extracellular Matrix Induced Morphology and Migration Changes in Brian Cancer Cells .........................................................................................................................................................................................656

Y. Cui, S. Cole, J. Winter

Human HER2- Positive Breast Cancer Cell Redirection In Vitro ............................................................................................................657A. Frank-Kamenetskii, J. Mook, B. Booth

Surface Modification of PCL Scaffold using Collagen Fibrillation for Muscle Tissue Regeneration ..................................................658S. J. Chae, J. Lee, M. Yeo, J. Lee, G. Kim, W. Kim

Phospholipid Polymer Multilayered Hydrogels Containing Cells for Cancer Drug Screening ............................................................659K. Ishihara, B. Gao, T. Konno

Surface Engineering of Macrophages with Nucleic Acid Aptamers for Capture of Tumor Cells ........................................................660Y. Iwasaki, S. Sugimoto

Alginate Based Hydrogel Platform for Cell Encapsulation .......................................................................................................................661S. Khanal, S. Tatum, J. Sankar, N. Bhattarai

The Effect of Migration on MSC Differentiation Through Activating Wnt Signal Pathway ................................................................662R. Yao, J. He, F. Wu

Understanding Structure-Property Relationships in Biological Tissues and Bioinspired Materials Using Non-Destructive Characterization Techniques ...................................................................................................................................................663

P. Labroo, J. Irvin, M. Petney, J. Johnson, N. Sopko

Single Cell Analysis Reveals the Instructive Role of 2D and 3D Engineered Microenvironments on Driving Stem Cell Behavior...................................................................................................................................................................................................664

A. Muniz, M. Brooks, D. Neale, T. Topal, A. Sze, M. Wicha, J. Lahann

Development of Vascularized 3D-Tissues with High ECM Density by Collagen Microfibers ..............................................................665Y. Naka II, K. Nishi II, M. Matsusaki

Extracellular Matrix Functionalized Multi-Cell Aggregate for Wound Repair .....................................................................................666P. Labroo, J. Irvin, N. Baetz, I. Robinson, J. Meiss, M. Sieverts, D. Miller, N. Sopko

Effect of Local Injection of Osteoblastic Cells Differentiated from Bone Marrow or Adipose Tissue-Mesenchymal Stromal Cells on Bone Repair .......................................................................................................................................................................667

G. Pereira Freitas, H. Bacha Lopes, A. T. Portilho De Souza, P. G. Faciola Pessôa De Oliveira, A. L. Gonçalves De Almeida, P. G. Coelho, M. M. Beloti, A. L. Rosa

Construction of Ceramic-polymeric Materials to Generate Neo Bone Tissue ........................................................................................668G. Flores, R. Olayo, J. Morales, A. Raya, D. Esquiliano, P. Ontiveros

FUNCTIONAL BIOMATERIALS TO CONTROL AND DIRECT CELLULAR FUNCTION Novel TiO2 Hemisphere Surface Matrices Determine the Osteogenic Differentiation and Mineralization of Pre-Osteoblastic Cells ............................................................................................................................................................................................669

Z. Yizhou, S. Wu, K. Yeung

Extended Exposure to Stiff Microenvironments Leads to Persistent Chromatin Remodeling in Human Mesenchymal Stem Cells ...............................................................................................................................................................................670

A. Killaars, J. Grim, C. Walker, E. Hushka, T. Brown, K. Anseth

Human Dermal Fibroblast Spheroids Combined with Platelets Rich Plasma Promote Skin Remodeling in a Skin Wrinkle Model of Aged Nude Mice ..............................................................................................................................................................671

S. Hu, Z. Li, K. Huang, T. Su, K. Cheng

Extracellular Matrix Derived from Chondrocytes Promotes Rapid Expansion of Human Primary Chondrocytes in vitro with Reduced Dedifferentiation...........................................................................................................................................................672

Y. Mao, T. Block, A. Singh-Varma, A. Sheldrake, R. Leeth, S. Griffey, J. Kohn

Temperature-dependent Binding of Growth Factors and Cells to a Heparin-Immobilized Thermoresponsive Surface .............................................................................................................................................................................................................673

J. Kobayashi, Y. Akiyama, M. Yamato, T. Okano

Photopatterned Protein Immobilization in Natural-based Hydrogels .....................................................................................................674I. Batalov, C. Deforest, K. Stevens

In vitro and in vivo Evaluation of Amorphous Silica Osteochondral Matrix..........................................................................................675H. Kim, S. Nukavarapu

Varying HRP Crosslinking Strategy Enables Tunable Fibrin Microthread Mechanical Properties ...................................................676M. Carnes, R. Mooney, C. Gonyea, J. Coburn, G. Pins

Vascularization is Mediated by Scaffold Pore Size to Direct Bone Marrow Stromal Cell Fate ............................................................677B. Swanson, P. Ma, M. Gupte, J. Hu, X. Jin, H. Ma, Z. Zhang, Z. Liu, K. Feng, G. Feng, G. Xiao, N. Hatch, Y. Mishina

A Cell Glue: Inducing Cell Adhesion Using Surface Modification with Cell-Penetrating Peptide-PEG-Lipid for 3D Cell Structures ................................................................................................................................................................................................678

Y. Teramura, S. Asif, E. Gustafson, K. Ekdahl, B. Nilsson

Modified Biomimetic Nanofibrous Scaffold Modulates Phenamil-Induced Stem Cell Differentation .................................................679Y. Liu, H. Sun

Enzymatically Triggered Shape Memory Polymers Direct Cell Alignment ............................................................................................680S. Buffington, M. Ali, P. Mather, J. Henderson

Reversible Dynamic Mechanics of Hydrogels for Regulation of Cell Behaviors.....................................................................................681O. Jeon, T.-H. Kim, E. Alsberg

Dynamic PEG-Peptide Hydrogels via Visible Light-Induced Tyrosine Dimerization............................................................................682C.-C. Lin, H.-Y. Liu

Iron Oxide Nanoparticles Suppress RANKL-induced Osteoclastogenesis through Regulating NF-κB and MAPK Signaling Pathways.........................................................................................................................................................................................683

L. Liu, J. Duan, L. Yang, R. Jin, H. Ai

Effect of Poly(Sophorolipid) Functionalization on Human Mesenchymal Stem Cell Osteogenesis and Immunomodulation ........................................................................................................................................................................................684

A. Arabiyat, P. Diaz Rodriguez, J. Erndt-Marino, F. Totsingan, S. Mekala, R. Gross, M. Hahn

Priming via Three-Dimensional Culture in Hydrogels Accelerates Retroviral Gene Transduction of Human Mesenchymal Stem Cells ...............................................................................................................................................................................685

B. Choi, Y. Lee, D. K. Han, S.-H. Lee

Bivalent Metal Ions Modulate Human Mesenchymal Stem Cell Osteogenic Differentiation ................................................................686A. Brokesh, A. Kersey, L. Cross, A. Gaharwar

Particle Based Hydrogel Heterogeneity for Controlled Cellular Infiltration ..........................................................................................687L. Pruett, D. Griffin

Visible-Light Triggered Shape Memory Polymers to Direct Cell Morphology ......................................................................................688S. Buffington, J. Henderson, J. Waimin, J. Apyapong, P. Mather

Glycosaminoglycans and Scaffold Morphology Influence Trabecular Meshwork Cell Behavior ........................................................689M. Osmond, M. Pantcheva, M. Krebs

Valence State of Cerium Oxide Nanoparticles Manipulate the Fate of Macrophages and Mesenchymal Stem Cells and Subsequent Bone Formation..................................................................................................................................................................690

K. Yeung, J. Li, J. Wei, W. Li, W. Qiao, J. Shen, W. Jin, X. Jiang, P. Chu, B. Li

Functionalized Polyurethane Foams as Tissue Scaffolds with Enhanced Cellular Response................................................................691M. C. Tanzi, D. Gantz, S. Bertoldi, N. Contessi Negrini, H. J. Haugen

Reversible Thermosensitivity of Completely Natural Mammalian Collagen Gels by Microfiberization.............................................692Y. Yukawa, H. Nakatsuji, S. Irie, M. Matsusaki

Modulation of Stem Cell Morphology and Differentiation Using a Mussel-Inspired Gelatin-Based Hydrogels ................................693S. Pacelli, S. Modaresi, A. R. Chakravarti, F. Elmi Vergel, C. Kurlbaum, M. Fang, F. Castanho, S. Basu, A. Paul

A Synthetic Replica Having Surface Morphology of Decellularized Tissue Regulated Orientation and Shape of Cells ..................................................................................................................................................................................................................694

T. Kimura, M. Kobayashi, Y. Hashimoto, T. Fujisato, N. Nakamura, A. Kishida

Multi-layered Films of Self-Assembled Capillary Alginate Hydrogel (CapgelTM) Induces Preferential Orientation of Human Foreskin Fibroblasts ....................................................................................................................................................................695

B. Willenberg, M. Kwan, C. Wheeless, M. Mathews, K. Crawford

Stimuli-responsive Sol-Gel Transition Polymers with Dynamic Crosslinks for Cell Culture ...............................................................696T. Miyata, Y. Natsume, A. Matsuda, K. Okuma, C. Norioka, K. Okita, A. Kawamura

Synthetic Hydrogel Culture Sequesters Extracellular Matrix Proteins and Promotes Fibroblast Proliferation................................697I. Kopyeva, C. Tomaszewski, A. Shikanov

Agarose for Mechanical Control of Self-Assembling Peptide Systems ....................................................................................................698K. Firipis, M. Boyd-Moss, A. Quigley, D. Nisbet, R. Williams

Effect of Freeze-Thaw Cycling on the Mechanics of Poly(Vinyl Alcohol)-Gelatin Cryo-Theta-Gels ...................................................699P. Charron, R. Oldinski

Dynamic Modulation of Gelatin Methacrylate Hydrogel Stiffness for Functional Maturation of Human Stem Cell-Derived Cardiac Tissues ................................................................................................................................................................................700

G. Tansik, A. Alassaf, V. Mayo, D. Velluto, A. Agarwal

Influence of Nuclear Morphology on Differentiation of Mesenchymal Stem Cells ................................................................................701X. Wang, V. Agrawal, C. Duan, B. Jiang, V. Backman, G. Ameer

Biorthogonal Shear Thinning Hydrogels to Generate Macroscale Cellular Organization and Spatially Patterned Microenvironmental Physiochemical Cues .................................................................................................................................................702

A. Dang, J. Gleghorn

Multicomponent Assembly of Biomaterial Scaffolds as Instructive Cellular Environments ................................................................703R. Williams, D. Nisbet, M. Boyd-Moss, K. Firipis

Porosity Effects on the Biocompatibility of PEEK and Titanium-6Aluminum-4Vanadium .................................................................704K. Nobles, P. Pal, A. Janorkar, R. Williamson

Pumpless Platform for High-throughput Dynamic Multicellular Culture and Chemosensitivity Evaluation ....................................705Z. Chen, S. He, W. Lee, J. Zilberberg

Application of Chemically Defined Polymer to Existing Cell Culture Materials for hMSC Expansion ..............................................706J. Krutty, K. Koesser, S. Schwartz, A. Dias, W. Murphy, P. Gopalan

IMMUNE ENGINEERING SIG Nanoparticle-mediated Knockdown of TGFBR2 Improves Natural Killer Cell Cytotoxicity ..............................................................707

I. Adjei, J. Jordan, N. Tu, T. L. Trinh, S. Wei, B. Sharma

Developing a 3D -Spatially Patterned Lymph Node Lobule on Chip .......................................................................................................708J. Ortiz-Cárdenas, R. Pompano, A. Montalbine

IMMUNOMODULATORY BIOMATERIALS Bioresponsive Microspheres for On-demand Delivery of Anti-inflammatory Cytokines for Inflammatory Arthritis ......................709

R. T. Annamalai, E. Park, M. Hart, B. Rolauffs, J. Stegemann

Targeting Infiltrating Immune Cells to Improve Articular Cartilage Regeneration .............................................................................710F. Taraballi, G. Bauza, L. Francis, A. Zhang, M. Hopson, S. Shaikh, F. Cabrera, X. Wang, A. Shi, D. Hamilton, P. Mcculloch, E. Tasciotti

Altering Metabolism Repolarizes Proinflammatory Human Macrophages ............................................................................................711B. Singh, K. Wofford, K. Spiller

Engineering PEG-4MAL Hydrogels for Tolerogenic Dendritic Cells ......................................................................................................712N. Beskid, A. García, J. Babensee

Identification of CD137-Exosomes and Exploration of Their Immunomodulatory Capacity...............................................................713Y. Zhou, H. Schwarz

Modulation of Macrophage Phenotype via Phagocytosis of Drug-Loaded Microparticles ...................................................................714K. Wofford, D Cullen, K. Spiller

Design of Rapidly Eroding Polyanhydride Nanoparticles for Drug and Vaccine Delivery ...................................................................715S. Kelly, A. Mullis, S. Jacobson, A. Mitra, B. Narasimhan

Crosslinking of Ovalbumin Nanoparticles Affects Cellular and Humoral Immune Responses............................................................716S. Christau, N. Habibi, L. Ochyl, M. Kuehnhammer, R. Von Klitzing, J. Moon, J. Lahann

Environment-Responsive Two-Fluorophore Reporter System: A Potential Tool to Monitor Particulate Vomocytosis.....................................................................................................................................................................................................717

N. Pacifici, A. Bolandparvaz, S. Shams, R. Stilhano, E. Silva, J. Lewis

An Improved Isolation Method of Tolerogenic Polysaccharides via High Performance Chromatography ........................................718R. Harriman, K. Alvarez, L. McKibbin, B. Noorafkan, J. Lewis

Biphasic Response of T Cell Activation to Substrate Rigidity...................................................................................................................719D. Yuan, L. Kam

Supplementing Cell Membrane-coated PLGA Nanoparticles with Exogenous Phosphatidylserine Reduces Inflammatory Cytokine Production in Macrophages ................................................................................................................................720

C. Kraynak, L. Suggs

NEXT-GENERATION BIOMATERIALS FOR TREATMENT OF TYPE 1 DIABETES Functionalization of Alginate with Rgd Peptide to Enhance Viability and Function of Encapsulated Islets ......................................721

J. Medina, A. Garcia, P. De Vos

Conformal Coating Process Refinement and Materials Optimization Improves the Insulin Secretion of Encapsulated Islets .........................................................................................................................................................................................722

A. Stock, D. Velluto, A. Tomei

Prototype Development of Macroencapsulation Device with Oxygen Generating Materials................................................................723M. Maruyama, T. Sasaki, M. Matsumori

BIOELECTRONICS AND BIOSENSORS Light-Controlled Engineered Axonal Tracts as “Living Electrodes” for Synaptic-Based Neuromodulation and Monitoring.......................................................................................................................................................................................................724

D. Adewole, L. Struzyna, J. Burrell, K. Browne, J. Wolf, H.-C. Chen, D. Cullen

Porous, Conductive Hydrogel Electrodes Designed to Improve the Recording Longevity of Neuroelectronic Interfaces .........................................................................................................................................................................................................725

L. Crawford, I. Dryg, N. Beeman, S. Perlmutter, B. Ratner

3D Printed Polypyrrole Microneedle Arrays for Electronically Controlled Drug Release ...................................................................726J. Huang, J. Johnson, R. Saigal

Organic, Flexible, and Biodegradable Silk Microstructures for Bioinspired Devices ............................................................................727V. Yadavalli, M. Xu, S. Pradhan

Mechanically Compliant Implants as a Strategy to Decrease Foreign Body Reaction to Nerve Interfaces.........................................728A. Carnicer-Lombarte, D. Barone, G. Malliaras, J. Fawcett, K. Franze

Localized Resveratrol Delivery Improves Recording Quality from Intracortical Microelectrodes .....................................................729Y. Kim, E. Ereifej, S. Meade, K. Chen, W. Schwartzman, H. Feng, J. Rayyan, J. Capadona

Developing a Mobile Health Solution for Treatment of Plantar Fasciitis................................................................................................730J. Johnson, J. McGreevey, L. Schenk, E. Bear, B. Shumpert, M. Bayer, V. Reukov

Development of Bipolar Electrochemical Nano-Bioelectronic Systems ...................................................................................................731A. Shaw, R. Rahman, R. Hague, F. Rawson

ENGINEERING BIOMATERIALS FOR TRANSLATIONAL PULMONARY RESEARCH Clickable, Hybrid Hydrogels as Tissue Culture Platforms for Modeling Chronic Pulmonary Diseases in vitro ...............................732

C. Petrou, N. Darling, D. Bölükbas, D. Wagner, C. Magin

Co-Culture of Lung Fibroblasts and Breast Cancer Cells in Boronic Acid-Based Hydrogels ..............................................................733S. Cassel, M. Smithmyer, C. Deng, P. Levalley, B. Sumerlin, A. Kloxin

FROM BENCH-TO-BEDSIDE: TRANSLATING BIOMATERIALS RESEARCH *BTI* Manufacturing Considerations for Producing and Assessing Decellularized Extracellular Matrix Hydrogels..................................734

M. Hernandez, G. Yakutis, K. Christman

Crystallinity and Reversibility in Injectable PVA/PEG Hydrogels ..........................................................................................................735V. Lamastro, E. Brewer, A. Lowman

Microplate Agar (MPA) - A Promising Miniaturized Protocol of the Ames Test...................................................................................736G. Umbuzeiro, D. Morales, F. Vacchi, A. Albuquerque, H. Freeman

Soft Tissue Reinforcement with Poly-4-hydroxybutyrate Mesh Scaffolds for Urogynecology Applications.......................................737D. Martin, B. Shah, D. Antonuccio, K. Guo, J. Scott, I. Toponarski, A. Ganatra, S. Rizk

In vitro Experimentation Elucidates Mechanisms of Reported Wound Healing Clinical Outcomes Using Amnion-Derived Fluid and Membrane Products ......................................................................................................................................................738

D. Dominguez, R. Audet, R. Diller, T. Bardsley, R. Kellar

Lubricant-Infused Urinary Catheters Prevent Bacterial Colonization in A Rat Model ........................................................................739M. Badv, F. Sayed, J. Faugeroux, D. Behr-Roussel, M. Rottman, T. Didar

New Technology to Reduce Complications and Procedure Time in Cranial and Spinal Surgery ........................................................740P. Modak, M. Nadig, W. Hammond, M. Jaffe, R. Russo

Development of Dual-Action Topical Therapeutics for Cytomegalovirus-Induced Hearing Loss .......................................................741M. Serban, E. Arrigali, E. Johnston, B. Serban

Development of an Implantable Inner Ear Corticosteroid Delivery System ...........................................................................................742E. Pierstorff, W.-W. Yang, Y.-J. A. Chen, F. Kalinec, W. Slattery

Does Annealing Improve the Interlayer Adhesion and Structural Integrity of FFF 3D printed PEEK Lumbar Spinal Cages? ..................................................................................................................................................................................................743

C. Basgul, T. Yu, D. Macdonald, R. Siskey, M. Marcolongo, S. Kurtz

Evaluation of Printing Parameters for Additive Manufacturing of Bioresorbable Devices ..................................................................744C. Culbreath, S. Taylor, S. McCullen, O. Mefford

Novel Technique for Creating Aligned Microfibers within 3D Printed Structures: A Preliminary Report........................................745M. S. Taylor, B. Gaerke

Biocompatibility of Fused Deposition Modeling 3D Printed Biomedical Devices ...................................................................................746S. Lyu, C. Bakken, S. Tuominen, G. Lyu, V. Bhatia, R. Lahm, E. Rankin, M. Bucheger

GASOTRANSMITTER DELIVERY FROM BIOMATERIALS Reduction of Biofouling and Infection of Indwelling Medical Devices via Combined Nitric Oxide (NO) Release and Antifouling Polymer Interfaces .....................................................................................................................................................................747

E. Brisbois, M. Chug, S. Hopkins, J. Pant, M. Douglass, C. Feit, H. Handa

Polymeric Micelle-Based Hydrogen Sulfide Donors...................................................................................................................................748U. Hasegawa, A. Van Der Vlies

Antibacterial and Cellular Response Towards a Gasotransmitter Based Wound Dressing..................................................................749J. Pant, S. Hopkins, M. Goudie, M. Douglass, H. Handa

MULTIFUNCTIONAL BIOMATERIALS: RECENT DEVELOPMENTS AND FUTURE DIRECTIONS Synthesis of Glycopolymers with Specificity for Bacterial Strains via Bacteria-Guided Polymerization ............................................750

Y. Luo, Y. Gu, R. Feng, G. Chen, H. Chen

Glycosylated Hydrogels for Tunable Capture and Release of Carbohydrate-Binding Proteins...........................................................751J. Olguin, M. Molinaro, G. Hudalla, A. Restuccia

Glycosaminoglycans-mimicking Polymers Conjugated Gold Nanoparticles for Promoting Neural Differentiation of Embryonic Stem Cells ....................................................................................................................................................................................752

L. Wang, S. Zhang, H. Chen

Co-assembling Tags for Modular Assembly of Glycosylated Peptide Nanomaterials............................................................................753D. Seroski, T. Roland, L. Astrab, G. Hudalla

Carbohydrate-based Biomaterial from Seafood Waste for Biomedical Applications ............................................................................754J. Chakravarty, M. F. Rabbi, V. Chalivendra, C.-L. Yang, T. Ferreira, C. Brigham

Identifying Small Colony Variants and Related Antimicrobial Treatments ...........................................................................................755B. Li, J. Kang, K. Cochran

Molecular Engineering Strategies for Designer Polyelectrolyte Nanocomplexes....................................................................................756J. Ting, H. Wu, S. Meng, A. Herzog-Arbeitman, M. Tirrell

Efficient Capture and Release of Rare Tumor Cells Using Microfiber Fabrics Modified with Multi-functional Peptide .............................................................................................................................................................................................................757

A. Yoshihara, R. Sekine, Y. Yamada, M. Takai

Thermoresponsive Hydrogels with Comb-Type Architecture for "Self-Cleaning" Glucose Biosensor Membranes .........................758P. Dong, A. Means, B. Schott, G. Coté, M. Grunlan

HDACs-targeting pH Probe for Intraoperative Detection of Metastatic Tumors and Chemotherapy ................................................759Y. Yang, J. Ling, Y. Ling, Y. Luo

Polyhydroxyalkanoates: A Family of Natural Polymers, for Medical Implant Development and Disease Modelling .......................760P. Basnett, R. Nigmatullin, F. Rodríguez, X. Mendibil, R. Ortiz, I. Quintana, J. Salber, P. Onganer, J. Knowles, I. Roy

Wet Spinning of Poly (4-hydroxybutyrate) to Produce Drug-loaded Fibers for Controlled Drug Delivery........................................761B. Singhi, E. Ford, M. King

Photoreactive Peptides for Micropatterning by Two Photon Photolysis .................................................................................................762K. Michael

Combination of Molecular Mobility of Sulfonated-Polyrotaxane and Growth Factors for Improving Hepatocyte Functions .........................................................................................................................................................................................................763

Y. Arisaka, N. Yui

In vivo Degradation and Host Response to Aliphatic Polycarbonates Degradable By Intra-Molecular Cyclization .........................764B. Amsden, S. Mohajeri

Filament Wound Collagen Sling for Treatment of Urinary Incontinence: in vivo Ovine Model..........................................................765I. Isali, A. Khalifa, H. Celik, C. Gillespie, R. Colbrunn, S. Shankar, K. Derwin, A. Hijaz, O. Akkus

Orthogonal Photochemistry for Wavelength-Selective Modulation of Dynamic Biomaterials .............................................................766S. Adelmund, K. Uto, P. Farahani, J. Wolfe, C. Deforest

Matrices from Genetically Engineered Plant Cell Lines as Three-Dimensional Scaffolds for Cell Growth........................................767J. Coburn, N. Phan, T. Wright, J. Xu

Thermo-responsive Copolymers for Enzyme-triggered Drug Delivery and Bioresorbable Scaffolds..................................................768K. Rosas Gomez, B. Vernon, A. Pal, K. Lein

Novel Crosslinkers Enabling Reversal of Crosslinking with Light ..........................................................................................................769H. Del Castillo, K. Michael

Isolation of CAR-T Cells with Modified Poly(vinyl) Alcohol Membranes...............................................................................................770B. Austin-Carter, E. Harris, N. Comolli, J. Elmer

Adaptation of Liquid Handling Robotics for High Throughput Customizable RAFT-Polymerization...............................................771M. Tamasi, S. Kosuri, R. Upadhya, A. Gormley

Engineering Liquid Crystalline Polymers for Biological Applications ....................................................................................................772J. Boothby, C. Ambulo, M. Saed, T. Ware

Regulation of Hydrogen Peroxide Generation from Mussel-inspired Adhesive via Silica Particle Incorporation .............................773R. Pinnaratip, R. Rajachar, B. Lee

RECENT ADVANCES IN ANTIMICROBIAL AND ANTIBIOFILM MATERIALS Engineering a Zinc Phosphate Coating on Zinc for Enhanced Biocompatibility and Antibacterial Property ...................................774

D. Zhu, Y. Su, Y. Zheng, Y.-X. Qin

Development of Small Animal Infection Model for Evaluating Barrier Properties of the Epidermal Seal against Infection Around the Percutaneous Implant Systems – A Pilot Study.....................................................................................................775

S. Jeyapalina, Z. Tiang, K. Bachus, J. Beck, M. Van Dyke, B. Bennett

An Alternative, Quantitative Method for Measurement of Bacterial Cell Coverage on Flat Samples Using SEM Image Analysis ................................................................................................................................................................................................776

M. Zurawski, C. Scotchford, S. Atkinson, D. Grant

Silver-Doped Titania Nanotubes; Processing, Characterization, and in vitro Cellular Interaction .....................................................777S. Vahabzadeh, M. K. Duvvuru

2-Heptylcyclopropane -1-carboxylic Acid Loaded Acylated Chitosan Membranes Inhibit Bacterial Biofilms ..................................778R. Awais, Z. Harrison, B. Raji, V. Murali, J. Bumgardner, D. Baker, J. Jennings

Development of a Polydopamine Antimicrobial Coating for Marine Applications ................................................................................779A. Tyo, S. Welch, P. Forooshani, R. Ping, B. Lee, A. Zerbini, J. Robbins, R. Rajachar

Zinc-oxide Nanoparticles Act Catalytically and Synergistically with Nitric Oxide Donors to Enhance Antimicrobial Efficacy ............................................................................................................................................................................................................780

P. Singha, C. Workman, J. Pant, S. Hopkins, H. Handa

Local Delivery of Diflunisal Protects Host Bone Tissue from S. Aureus Biofilm-Induced Bone Destruction .....................................781T. Spoonmore, A. Hendrix, J. Cassat, S. Guelcher

Fabrication of Cytocompatible Self-Assembling Antimicrobial Nanofibers Via Peptide Self-assembly..............................................782H. Dong, D. Xu, W. Chen, W. Qiang

Mannose Conjugated Polymer Binding in the P. Aeruginosa Biofilm .....................................................................................................783E. Limqueco, D. Passos Da Silva, F.-Y. Su, C. Reichhardt, J. Chen, D. Das, M. Parsek, P. Stayton, D. Ratner

Smart Antibacterial Surfaces Fabricated via Layer-By-Layer Deposition and Host-Guest Interaction .............................................784T. Wei, W. Zhan, Q. Yu, H. Chen

Quantifying the Natural Antimicrobial Properties of N-halamine-based Cotton Against MRSA........................................................785T. Hoekstra, Y. Deng, Y. Sun

A Novel Highly-Adherent Polymer Coating to Prevent Orthopedic Pin-site Infections. .......................................................................786M. Bredikhin, C. Gross, I. Luzinov, A. Vertegel

Polymer-Nanoparticle Interaction as a Design Principle in the Development of a Durable Ultra-Thin Universal Binary Anti-Biofilm Coating with Long-Term Activity.............................................................................................................................787

Y. Mei, K. Yu, D. Lange, J. Kizhakkedathu

Metallic Implant Surface Modification Process for Enhanced Biofilm Resistance ................................................................................788J. Desjardins, C. Bales, S. Helms, L. O'Neill

A Substrate-Independent Smart Antibacterial Surface for the Rapid and Effective Killing and Release of Adherent Bacteria ............................................................................................................................................................................................................789

Y. Qu, T. Wei, J. Zhao, S. Jiang, P. Yang, Q. Yu, H. Chen

Addressing the Challenges of Bioactive and Antibacterial Thin Film Formation Using the Spin Coating Technique ......................790L. Soule, X. Chatzistavrou

A Murine Model of Cutaneous Aspergillosis for Evaluation of Biomaterials-based Local Delivery Therapies .................................791A. Tatara, E. Watson, N. Albert, P. Kontoyiannis, D. Kontoyiannis, A. Mikos

TARGETED AND STIMULI-RESPONSIVE BIOMATERIALS Fucoidan-coated Fibrous Mesh as a Skin Patch to Treat Melanoma .......................................................................................................792

C. Oliveira, N. Neves, R. Reis, T. Silva, A. Martins

Neutralization of Pro-inflammatory Cytokines by Intra-articular Injection of Biofunctionalized Nanoparticles as an Advanced Treatment for Osteoarthritis .................................................................................................................................................793

A. Lima, D. Amorim, I. Laranjeira, A. Almeida, H. Ferreira, F. Pinto-Ribeiro, N. Neves

Stimulus-Responsive Drug Delivery from PEGylated Polyvinylidene Fluoride- Polypyrrole Core-Shell Fibers ...............................794S. Miar, F. Acosta, T. Guda

Redox-Active Layer-by-Layer Coatings Containing Cerium Oxide Nanoparticles for the Encapsulation of Cellular Spheroids .........................................................................................................................................................................................................795

N. Abuid, K. Gattas-Asfura, C. Stabler

Light-Induced, Surface Mediated Gene Transfection on TiO2 Nanorods / Collagen / Au Composite Coatings ................................796K. Cheng, W. Weng, X. He

Chondrogenic Inductive Nanofibrous Mesh Biofunctionalized with Human Fibronectin ....................................................................797M. Casanova, R. Reis, A. Martins, N. Neves

Effect of CAD/CAM Dental Materials Composition on the Adhesion to the Cement Interface ...........................................................798H. G. Deery, E. Teixeira, S. Armstrong, C. Vidal

Graphene Oxide-bone Morphogenic Protein2 Complex Coating by Facile In-situ Deposition.............................................................799E.-J. Lee, J.-S. Oh

A Novel Chromogenic β-Lactamase Substrate for Diagnostic Biomaterials ...........................................................................................800H. Safford, D. Alkekhia, S. Shukla, A. Shukla

Tailoring Gelation and Mechanical Properties of Fibrin-Based Extracellular Matrix Using Stimulus-Responsive Poly(Lactic-co-Glycolic Acid) Microgelator ................................................................................................................................................801

Y.-T. Hong, H. Kong

An Avidin-Biotin Nanoparticle System for Detecting and Treating Inflammatory Diseases ................................................................802M. K. Khang, J. Zhou, L. Tang, Y. Huang, A. Hakamivala

Reactive Oxygen Species Sensitive Polymeric Micelles for Anti-Cancer Drug Delivery........................................................................803E. Radaha, A. Van Der Vlies, U. Haegawa

Direct Removal of Circulating Leukemia Cells by Magnetic Hyperthermia ..........................................................................................804H. Al Faruque, E.-S. Choi, J.-H. Kim, E. Kim

Evaluation of the Properties of Mechanically Stretched Poly (N-isopropylacrylamide) Gel Grafted Polydimethylsiloxane Surfaces ......................................................................................................................................................................805

Y. Akiyama, N. Takeda, M. Yamato, T. Okano

In situ Formation of Fluorescent Extracellular Vesicles (EVs) .................................................................................................................806M. Chen, Y. Xiang, A. Waspe, C. Heyn, J. Rutka, J. Drake, N. Matsuura

pH-Responsive Polymeric Nanoparticles for the Oral Delivery of High Isoelectric Point Therapeutic Proteins ...............................807H. Oldenkamp, M. Koetting, N. Peppas

Removal of Trimethylamine N-oxide During Hemodialysis Using Molecularly Imprinted Polymers .................................................808R. Tang, B. Ratner

NANOMATERIALS SIG Improved Neural Differentiation of Stem Cells via Magnetic Iron Oxide Nanoparticles under Magnetic Field................................809

R. Dai, Y. Pan, H. Chen

Enhancement of Antimicrobial Activity of Silver Nanoplates by Gold Coating and Control of the Activity by Light Irradiation .......................................................................................................................................................................................................810

T. Niidome, K. Kyaw, H. Ichimaru, A. Harada, Y. Miyazawa, M. Daigou

Research of the Role of MicroRNAs in Cytotoxicity Induced by Silver Nanoparticles..........................................................................811Y. Huang, X. Lü

Effect of Laser Pulse Width on Bioactivity of Titania Nanofibrous Structures Deposited on Glass Substrate via High Intensity Laser Induced Reverse Transfer Method (HILIRT) ........................................................................................................812

A. Kiani, N. Safaie, M.-H. Beigi, M.-H. Nasr-Esfahani

Engineering Antibacterial Nanosurfaces for Clinical Implementation....................................................................................................813J. Moxley, P. Ghannadian, T. Webster

Mass Production of Biocompatible Graphene Using Silk Nanofibers ......................................................................................................814X. Zhang, Q. Lu

Green Synthesis of a Synergetic Structure of Tellurium Nanowires and Metallic Nanoparticles for Biomedical Applications.....................................................................................................................................................................................................815

A. V. Crua, D. Medina, B. Zhang, T. Webster

Group Distribution: An Ignored Determinant for Silk Chemical Modification .....................................................................................816Y. Hang, Q. Lu, H. Chen

Influences of Material Factors on the Anti-Melanoma Effects of Hydroxyapatite Nanoparticle .........................................................817X. Zhu, H. Wu, X. Yang, X. Zhang, Z. Li, L. Wang

Engineering TiO2 Nanotube Growth on Titanium Implant to Enhance its Biotribological Performance & Biocorrosion-resistance..................................................................................................................................................................................818

J. Luo, S. Ma, S. Ajami, F. Zhou, C. Liu

NIR-mediated Spatiotemporal Control of Stem Cell Fate Using Multifunctional Upconversion Nanoparticles ................................819Y. Zhang, K.-B. Lee

SEEING MORE CLEARLY: NANOPARTICLE IMAGING PROBES IN BIOMEDICINE Predicting Rupture Potential of Abdominal Aortic Aneurysms with Gold Nanoparticles Targeting to Degraded Elastin in an Angiotensin II Induced Mouse Model ...................................................................................................................................820

X. Wang, B. Lane, J. Eberth, S. Lessner, N. Vyavahare

Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography .............................................821Y. Dong, M. Hajfathalian, J. Hsu, P. Naha, J. Kim, P. Chhour, P. Maidment, H. Litt, D. Cormode

Material Decomposition of Elemental Ca and P Using Photon-Counting Spectral Computed Tomography .....................................822T. Curtis, R. Roeder

The Intracellular Interaction of HA-based Nanocrystals with Uniform Shape and Traceable Fluorescence .....................................823X. Li, H. Chen, W. Li

Biodistribution of Cancer Stem Cells Targeting Nanoparticle Image Contrast Agents and It’s Implications in Early Diagnosis ...............................................................................................................................................................................................824

P. Nallathamby, K. Cowden Dahl, R. Roeder

Tumor Targetable High-field MRI T1 Contrast Conjugates With Gd(III)-chelate Complexes and Protein Cage Nanoparticles ..................................................................................................................................................................................................825

H. Kim, S. Jin, H. Choi, Y. Bae, M. Kang, H. Cho, S. Kang

Optimization of Energy Thresholds for Multi-Contrast Imaging in Photon-Counting Spectral Computed Tomography ....................................................................................................................................................................................................826

T. Curtis, R. Roeder

Contrast-Enhanced Mammographic Detection of Breast Microcalcifications Using Targeted Gold Nanoparticles..........................827T. Finamore, E. Gies, T. Vargo-Gogola, R. Roeder

Radiographic Detection Limits for HER2+ Breast Cancer Cells Immunotargeted by Gold Nanoparticles........................................828T. McGinnity, T. Curtis, T. Vargo-Gogola, R. Roeder

Evaluation of Quantum Dots as Marker for Her2-Positive Breast Cancer Cells....................................................................................829A. Frank-Kamenetskii, A. Thomson, L. Pasig, M. Kouame, M. Hedge, R. Abdel-Tawab, W. Ashley, V. Reukov

SUPRAMOLECULAR NANOMATERIALS FOR DRUG DELIVERY, IMAGING, AND IMMUNOENGINEERING Liquid Crystalline Biomaterials with Shape Memory Properties Synthesized using Click Chemistry................................................830

K. Burke, Y. Wang, S. Wimberley

Poly(ethylene glycol) Click Hydrogels with Embedded Sensing Microdomains for a Long-term, Implantable Biosensor..........................................................................................................................................................................................................831

V. Baldock, F. Jivan, D. Alge, M. McShane

Supramolecular Hydrogels Fabricated from Co-assembling Peptides as Locally-injectable Biomaterials .........................................832B. Soto-Morales, G. Hudalla

Supramolecular Assembly of Electrospun Hydrogel Nanofibers for Mimicking Fibrous Tissue Architecture ..................................833B. Miller, O. Nicholas, A. Jackson, C. Highley, S. Caliari

Development of Therapeutic Vaccine by Antigen Presenting Cells Targeting Self-Assembled Nanogel .............................................834R. Miura, S.-I. Sawada, Y. Sasaki, K. Akiyoshi

Relating Chemical and Physical Properties of Oligonucleotide Polyelectrolyte Complex Micelles......................................................835A. Marras, J. Vieregg, J. Ting, M. Tirrell

Size, Charge, and Adjuvant Incorporation Impact Peptide Amphiphile Micelles Vaccine Bioactivity ...............................................836R. Zhang, B. Rygelski, J. Smith, X. Wang, B. Allen, J. Kramer, B. Ulery

Applications of Self-assembling Ultrashort Peptides in Bionanotechnology ...........................................................................................837M. Ni, S. Zhuo

OPHTHALMIC BIOMATERIALS SIG Characterization of Silk-hyaluronic Acid Hydrogels as Vitreous Humor Substitutes ...........................................................................839

N. Raia, C. Ghezzi, D. Kaplan

Nanofiber-Reinforced Hydrogels for the Stabilization of Open Globe Injuries......................................................................................840L. Costella, L. Woodard, K. Broderick, A. Eiseman, C. Tison

Development of a Benchtop Corneal Puncture Model Suitable for Testing Biomaterial Therapeutics ...............................................841E. Snider, J. Acevedo, P. Edsall, B. Lund, D. Zamora

Evaluation of Semi-Interpenetrating Network for Treating Traumatic Optic Neuropathy..................................................................842A. Soltisz, S. Thobe, M. Ruzga, M. Reilly, K. Swindle-Reilly

Study on Contact Lens for Blocking Blue Light .........................................................................................................................................843J. Lee, S. An, H. Choi, J. K. Kim

New Routes to Mucoadhesive Block Copolymer Micelles for Ocular Drug Delivery.............................................................................844T. Rambarran, H. Sheardown

Effect of Multipurpose Care Solutions Upon Physical Dimensions of Silicone Hydrogel Contact Lenses ..........................................845D. Zhu, S. Smith, D. Pierre, J. Gilbert, J. Chinn

Engineering Injectable Synthetic ECM-Based Hydrogel as Vehicles for Retinal Progenitor Cells Transplantation.........................846J. Kundu, P. Zhao, A. Desai, M. Rezaeeyazdi, S. Bencherif, M. Young, J. Monaghan, S.-Y. Kim, R. Linhardt, R. Carrier

ORTHOPEDIC BIOMATERIALS SIG High Adhesiveness and Hardness Hydroxyapatite .....................................................................................................................................847

Y. Kushiki, S. Minami, Y. Tsumura, A. Bando, N. Kitamura

Advanced Control of Hydroxyapatite/β-TCP Ratio in Fiber ....................................................................................................................848Y. Kushiki, Y. Konishi, D. Miyagi, Y. Tsumura, N. Kitamura

Titanium Anodization; Effects of Chemistry and in vitro Interaction with Bone Marrow Stromal Cells...........................................849W. Han, M. K. Duvvuru, S. Vahabzadeh, S. Elsawa

Glycosaminoglycan Incorporation into Particle-Based Hydrogels for Enhanced Articular Cartilage Regeneration ........................850B. Pfaff, N. Cornell, P. Cottler, C. Schaeffer, B. Degeorge, D. Griffin

Modeling and Characterization of Porous Tantalum (Ta) Scaffolds .......................................................................................................851B. Golla, S. Mamidi, V. Raja, M. Ali, A. Yadav, S. Chandra, K. Shivkumar, M. Mathew

Collagen Hydrogel Models for Investigating Macrophage Inflammatory Response to Wear Particles...............................................852P. Turner, E. Sussman, J. Stegemann

Injectable Gelatin Microcarriers for Osteogenic Induction of MSCs for Bone Regeneration ..............................................................853C. Nweke, R. T. Annamalai, J. Stegemann

Engineered Bio-composite Scaffold with Controlled Magnesium Ion Release for Bone Defect Repairing .........................................854J. Shen, K. W. K. Yeung

Biological and Corrosion Behavior of 3D Printed Titanium Alloy for Biomedical Application ...........................................................855D. Morris, D. Bijukumar, E. Ceppi, P. Tsai, M. Wu, A. Orias, M. Mathew

Analgesic-Eluting UHMWPE Promises Antimicrobial Prophylaxis After Primary Arthroplasty.......................................................856D. Gil, S. Grindy, O. Muratoglu, H. Bedair, E. Oral

Analgesic-Loaded UHMWPE Can Improve the Efficacy of Antibacterial Therapy for Prosthetic Joint Infections .........................857D. Gil, S. Grindy, K. Laplante, K. Daffinee, O. Muratoglu, H. Bedair, E. Oral

Establishing a Periprosthetic Infection Model in Rats ............................................................................................................................... 858E. Oral, Y. Xiao, W. Sabuhi, C. Leape, Y. Fan, D. Gil, O. Muratoglu, J. Collins, M. Randolph

Injectable Chemokine Loaded Fibrin Gel for Glenoid Labrum Tear Repair and Regeneration .........................................................859L. Tang, S. Li, J. Zhou, J. Borrelli

Mechanical Compression Improves Decellularization of Intact Intervertebral Disc Xenografts .........................................................860V. Casler, A. Garon, M. Krussig, M. Namiranian, J. Walters, J. Mercuri

3D Printing of Poly Lactic Acid (PLA)/nano-hydroxyapatite (HA) Composites for Bone Tissue Engineering ..................................861H.-D. Jung, J. Lee, T.-S. Jang

Mechanical Evaluation of Woven Collagen Patch for Rotator Cuff Tendon Repair .............................................................................862Y. Huang, Y. Xie, M. King

The Effect of Autoclaving on Rheological and Mechanical Properties of Thermogelling Chitosan-Based Nanocomposite Hydrogel...............................................................................................................................................................................863

S. M. Latifi, C. Tang, H. J. Donahue

Injectable Biodegradable Elastomer to Aid in Healing of Bone Fractures..............................................................................................864J. Sanabria, S. Huddleston, G. Ameer

Investigation into Soft Tissue Micro-Tearing and Repair Mechanisms as it Relates to Sports Injuries..............................................865O. Newkirk, M. Maggio, M. Judge, A. Seilkop, K. Lindsey, A. Santore, M. Hermanns, E. Caruso, D. Dean

Serioss: A Bone Graft Substitute with Autograft like Properties .............................................................................................................866S. Shukla, A. Nisal, R. Deshpande, S. Salunke

Impacts of Bone Scaffold Architecture on Vascular Network Development...........................................................................................867C. Perez, A. Boehme, F. Acosta, S. Montelongo, C. Rathbone, J. Ong, T. Guda

PROTEIN AND CELLS AT INTERFACES SIG PAMA-Arg Brush-Functionalized Magnetic Nanocomposites for Phosphorylated Biomolecule Enrichment ...................................868

F. Lan, B. Luo, Y. Wu

Antibody-Armed Platelets for Regenerative Targeting of Endogenous Stem Cells................................................................................870Z. Li, S. Hu, K. Huang, T. Su, K. Cheng

DEVELOPING BETTER BIOMATERIALS: ADVANCES IN TECHNOLOGIES AND UNDERSTANDING OF SURFACE MODIFICATION Titanium with Nanotopography Induces Osteoblast and Inhibits Osteoclast Differentiation ..............................................................871

H. Lopes, R. Bighetti, B. Poker, L. Castro-Raucci, E. Ferraz, A. Souza, G. Freitas, A. Rosa, M. Beloti

Switching Biological Functionalities of PDMS-based Microfluidic Systems ...........................................................................................872S. Li, X. Liu, H. Chen

Resistance to Protein Adsorption and Cell Adhesion on the Surface Immobilized with Oligo-Peptide Mimicking Collagen Backbone Structure .......................................................................................................................................................................873

S. Kakinoki, Y. Noguchi, Y. Hirano

Sol-gel Based Hyaluronic Acid-Silica Nanocomposite with Lubricative Performance for Intravascular Guidewire ........................874C. Hwang, J. Kim, S. Park, H.-E. Kim, S.-H. Jeong

Evaluation of Immune Response of Macrophages Using Bioactive Nanotopography Surfaces on Titanium Alloy (Ti6Al4V) Designed by Directed Irradiation Synthesis..............................................................................................................................875

A. Civantos, A. Mesa, C. Jaramillo, A. Barnwell, A. Shetty, J. P. Allain

Anodized/etched and DIS Treated Ti Surfaces to Promote Bone Formation..........................................................................................876A. Mesa, R. Montes, E. Patiño, J. F. Alzate, A. Civantos, N. Balcázar, J. J. Pavón, J. P. Allain

SURFACE CHARACTERIZATION AND MODIFICATION SIG A Novel Zwitterionic Polymer for Surface Modification of Polypropylene: Synthesis, Surface Characterization, Antimicrobial Adhesion and Hemocompatibility .......................................................................................................................................877

J.-C. Lin, C.-S. Hung, C.-H. Cheng

A Quaternary Ammonium Bromide-Containing Polymer for Polyurethane Surface Modification ....................................................878R. Almousa, L. Howard, D. Xie

Improvement of Surface Adhesion of Electrosprayed Chitosan Coatings to Titanium Substrates ......................................................879B. Watson, R. Gopalakrishnan, T. Fujiwara, J. Bumgardner

Surface Energy of Albumins and the Effect of Relative Humidity ...........................................................................................................880D. Burnett, V. Karde, J. Heng

Characterization of Bioglass Deposited on Porous TiO2 Produced by Plasma Electrolytic Oxidation ................................................881P. Soares, L. Bemben, D. Weiss, R. Sabino, K. Popat

Label-free 3D Imaging Surface Modifications within Biomaterial Scaffolds using Time-of-Flight Secondary Ion Mass Spectrometry .........................................................................................................................................................................................882

M. Taylor, D. Graham, L. Gamble

3D BIOPRINTING APPLICATIONS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE An Innovative Cell-laden a-TCP/collagen Scaffold Fabricated Using a Two-step Printing Process for Potential Application in Regenerating Hard Tissues ..................................................................................................................................................883

W. Kim, J. Lee, M. Yeo, J. Lee, S. Chae, J. Kim, H.-S. Yun, G. Kim

Cell-laden Prionace Glauca Skin Collagen-based 3D Printed Scaffolds for the Engineering of Mineralized Tissues .......................884G. Diogo, C. Marques, R. Pérez-Martin, R. Pirraco, C. Sotelo, R. Reis, T. Silva

Novel 3D Printed Poly(ethylene glycol) Dimethacrylate Based Photocurable Scaffolds for Bone Regeneration: in vitro and in vivo Evaluation ..........................................................................................................................................................................885

J. Unagolla, B. Gaihre, C. Jayasuriya

Fabrication of M13-Bacteriophage-Conjugated Alginate Scaffold for Hard Tissue Engineering ........................................................886J. Lee, S. Chae, W. Kim, M. Yeo, G. Kim

Aligned Microfibrous Bundle Structure Fabricated Using Electrohydrodynamic Jet Printing and Cell Printing Process for Muscle Regeneration..................................................................................................................................................................887

M. Yeo, W. Kim, J. Lee, S. J. Chae, G. H. Kim

A Bioengineered 3D Printed Calciumalkaliorthophosphate-based Bone Graft Facilitates Repair of Critical-Size Segmental Discontinuity Bone Defects in vivo ............................................................................................................................................888

C. Knabe, M. Stiller, M. Kampschulte, B. Peleska, R. Gildenhaar, G. Berger, A. Rack, C. Gomes, J. Gunster, U. Linow, D. Adel-Khattab, A. Houshmand, K. Ghaffar, A. Gamal, M. El-Mofty

Hierarchical 3D Scaffolds for Bone Tissue Engineering: Full Factorial Design and Dynamic Cell Culture.......................................889A. Yousefi, S. Koo, J. Powers, J. Liu, K. Sampson, B. Marks, K. Wood, P. Franz, O. Koury, P. James, J. Zhang

Rheological Characterization of Bioinks for Cell-based 3D Bioprinting .................................................................................................890M. Elizondo, G. Gillispie, S. Lee, J. Yoo, A. Atala

Bioprinting of Three-Dimensional Microtissues to Evaluate Adipocyte-Breast Cancer Cell Interactions ..........................................891S. Chaji, J. Alsaleh, C. Gomillion

3D Printing Technique to Produce Biomaterial Scaffolds with Tailored Hierarchical Porosity ..........................................................892Z. Wang, S. Florczyk

Thermal Inkjet Printed Endothelial Cells Cause Microvasculature Formation in Host Tissues via Heat shock Protein Induced VGEF Release ....................................................................................................................................................................893

T. Boland, B. Oropeza, L. Solis, M. Yanez

3D-Printing Patterned Biocompatible Hydrogels to Promote Angiogenic Sprouting ............................................................................894C. Pan, G. Calderon, S. Paulsen, D. Sazer, B. Grigoryan, J. Miller

Development and Evaluation of a Perfusable Dual Hydrogel System for Prevascularization in Tissue Engineering........................895S. Kim, C.-C. Pan, Y. Yang

Three-dimensional Extrusion Bioprinting of Self-healing Hydrogel for Tissue Regeneration..............................................................896K. Y. Lee, S. W. Kim, H. H. Roh, H. S. Kim

Architectures of 3D Printed, Sintered β –TCP Scaffolds Optimized for Strength and Permeability ...................................................897G. Chiou, S. Montelongo, S. Miar, J. Ong, T. Guda

3D PRINTING AND BIOENGINEERED TISSUES FOR IN VITRO MODELING OF DISEASE PROCESS AND DRUG SCREENING Cancer Extracellular Vesicles Derived Supported Lipid Bilayer as a Platform for Cell Culture to Understand Interactions between Adipose Stem Cells and Oncogenic Extracellular Vesicles ...................................................................................898

J. Uribe, H.-Y. Liu, C. Fischbach, S. Daniel

Digitization and Solid Deposition for Layer-By-Layer 3D Biofabrication of Varying Bone Densities.................................................899T. Burg, K. Burg, J. Williams, N. Morris

Comparison of Human and Porcine Pancreatic Decellularized Extracellular Matrix Bioink Using Proteomic Approaches......................................................................................................................................................................................................900

M. Kim, J. Kim, I. K. Shim, S. C. Kim, J. Jang

3D Printable Polydimethylsiloxane for Hybridized Scaffolding in Building Biomimetic Tissue ..........................................................901M. Heon, D. Aks, M. He

Fabrication of Artificial Skin Model Using Decellular Extracellular Matrix Bioink .............................................................................902M.-J. Kim, I. Jang, J.-H. Shim, W.-S. Yun, S. Jin

Printing Mechanically Tunable Cardiac Decellularized Extracellular Matrix Bioinks for Modeling Cardiac Fibrosis.............................................................................................................................................................................................................903

Y. J. Shin, R. Shafranek, J. Tsui, A. Nelson, D.-H. Kim

ADVANCED FABRICATION APPROACHES FOR MULTISCALE TISSUE ENGINEERING High and Low Perfusion Microvascular Breast Tumor Mimetic Chip for Anti-Cancer Drug Screening ...........................................904

B. Anbiah, I. Hassani, N. Habbit, R. Arnold, B. Prabhakarpandian, E. Lipke

A Scalable Xeno-Free Microcarrier-based Suspension Bioreactor System for Biomanufacturing of Human Mesenchymal Stem Cells (hMSCs) for Regenerative Medicine ................................................................................................................905

J. Lembong, R. Kirian, D. Wang, J. Rowley, T. Ahsan

Three-Dimensional Printable Hydrogel Precursor Bioinks as Growth Factor Delivery Vehicles ........................................................906S. Li, S. Yerneni, A. Feinberg, P. Campbell

Intentional Positioning of Cells in a Decellularized Heart .........................................................................................................................907B. Berron, C. Li, M. Montalvo, A. Abdel-Latif

Printing Colloidal Microgel Particles for Modular Tissue Engineering ..................................................................................................908D. Chester, T. Ngobili, M. Daniele, A. Brown

Preparation of Electrospun Nanofibers with Desired Microstructures Using a Programmed 3D Nanofiber Collector ..........................................................................................................................................................................................................909

W. Ren, L. Chen, A. Al-Shawk, X. Wu, C. Rea, W. Chen, D. Markel

Programming via Printing: Printing of Ready-to-Trigger, Biocompatible, Shape-Memory Polymers ...............................................910K. Pieri, P. Chando, P. Soman, J. Henderson

BIOMATERIALS FOR REGENERATIVE ENGINEERING Cellular Response of MC3T3 E1 Cells on Nanofiber Shish Kebab Periodicity and Size .......................................................................911

T. Yu, M. Marcolongo, C. Li

Co-Culture of Osteoblasts and Endothelial Cells in a Chitosan/ GDP Scaffold to Improve Angiogenesis and Osteogenesis for the Treatment of Critical Size Bone Defects...................................................................................................................912

C. Agnes, T. Baudequin, M. Tabrizian

Compaction and Crosslinking of Nucleus Pulposus Replacement Improves Repair Efficacy in Spinal Kinematic Model ...............................................................................................................................................................................................................913

A. Garon, R. Borem, J. Walters, J. Mercuri

Impact of Fibrin Microparticle Crosslinking Density on Physical and Rheological Properties of Composite Polyethylene Glycol-Fibrin Microparticle Hydrogels for use in Tendon Repair ....................................................................................914

K. Caspers, K. Meyers, M. Kwesiga, B. Lee, R. Rajachar

PLLA-PEG-PLLA Triblock Copolymers as Biodegradable Thermoplastic Elastomers for Nerve Guidance Channels ..........................................................................................................................................................................................................915

Y. Hu, W. Wu, A. Ekenseair

Integrating Experiments and MD Simulations to Determine Hydrolytic Degradation of Aliphatic Polyesters for Surgical Suture Applications.........................................................................................................................................................................916

R. Vaid, M. King, M. Pasquinelli

Nanofiber-Hydrogel Composite Microparticles as a Stem Cell Delivery and Pro-Regenerative Material for Soft Tissue Defects ..................................................................................................................................................................................................917

C. Chang, C. Zhang, J. Chua, Z. Yao, R. Martin, K. Colbert, H. Mao

Characterization of Detachable Gelatin/Chitosan Hydrogel for Tissue Engineering Applications......................................................918K. Kret, A. Campbell Ritchie, C. Scotchford

Physical and Chemical Characterization of Synthetic Bone Mineral Ink for Robocasting Applications ............................................919L. Witek, D. Eckstein, C. Rivera, D. Mijares, P. Coelho

Nanofibers with Controlled Deformation ....................................................................................................................................................920Y. H. Jeong, J. Kim, C. Park

Silk Biomaterials with Multiple Cues for Vascularization Capacity ........................................................................................................921Q. Lu, Z. Ding, D. Kaplan

Comparative in vitro Study of 3D Robocasting Scaffolds Using Beta Tricalcium Phosphate and Synthetic Bone Mineral.............................................................................................................................................................................................................922

C. Rivera, L. Witek, D. Mijares, A. Larranaga-Vega, B. Cronstein, P. Coelho

Oriented Immobilization of Basic Fibroblast Growth Factor: a Novel Bioengineered Surface Design for the Expansion of Mesenchymal Stem Cells........................................................................................................................................................923

A. Shakya, E. Imado, N. K. Phuong, T. Matsuyama, K. Horimoto, I. Hirata, K. Kato

Mis-concepts About Collagen in Regenerative Biomaterial Matrices ......................................................................................................924S. Gunasekaran, C. Cox

Collagen Type I and II Blend Hydrogels with Mesenchymal Stem Cells as a Scaffold for Articular Cartilage Defect Repair...............................................................................................................................................................................................................925

J. Liu, C. Kilmer, A. Durkes, G. Breur, A. Panitch

A Hybrid Dendrimer Hydrogel as Bone Tuberculosis Defect Scaffold for Regeneration and Chemotherapy ...................................926J. Wang, R. Cooper, B. Li, H. Yang

Nanofiber Microspheres for Cell Delivery...................................................................................................................................................927J. Xie, J. John, S. Boda

Defect Driven Gelation of 2D Nano-assemblies and Polymeric Binder for Bone Tissue Engineering..................................................928K. Deo, M. Jaisawal, S. Bhunia, A. Gaharwar

Cryogenic Formation of Multi-Layered Hydrogel Scaffolds with Tunable Interfaces ..........................................................................929A. Najarzadeh, E. Pyles, D. Puleo

2D Nanomaterials Functionalized 3D Nanofibrous Scaffolds for Bone Regeneration ...........................................................................930H. Sun, Q. Yao

β-Tricalcium Phosphate (β-TCP) Scaffold Promote Cell Infiltration in vitro.........................................................................................931X. Wang, M. Lin, Y. Kang

Performance of an Octacalcium Phosphate Biomaterial in a Long Bone Defect in Ovariectomized Rat ............................................932O. Suzuki, K. Baba, Y. Shiwaku, T. Anada, Y. Mori, K. Tsuchiya, E. Itoi

Wound Healing Evaluation of Equine Amniotic Membrane Compared to Commercially Available Porcine Xenografts .......................................................................................................................................................................................................933

R. Early, H. Hewitt, H. Aberman

Synthesis and Characterization of an Elastic and Biodegradable Poly(Xylitol-Dodecanedioic Acid) for Biomedical Engineering Applications...............................................................................................................................................................................934

N. Firoozi, Y. Kang

In Vitro Model of Schwann Cell Migration in Multilayered Clickable Microsphere-Based Scaffolds with Tunable Degradation Rates ..........................................................................................................................................................................................935

H. Meng, D. Elbert

Immunodeficiency Potentiates the Ability of Decellularized Muscle Matrix to Regenerate a Volumetric Muscle Injury ...............................................................................................................................................................................................................936

L. Olson, D. Cohen, B. Boyan, Z. Schwartz, M. McClure

Decellularized Materials Derived from Genetically Engineered Mice with Enhanced Regenerative Potential ..................................937T. Kyriakides, A. Morris

Identifying the Cell-Cell Communication Network Driving Methacrylic Acid (MAA)-Based Biomaterial Nerve Growth .............................................................................................................................................................................................................938

A. Androschuk, I. Talior-Volodarsky, R. Mahou, M. Sefton

Biomimetic Modification of Thermoresponsive Hydrogel Scaffolds for Enhanced Mucoadhesion .....................................................939N. Kanetkar, A. Ekenseair

Oxygen-generating Polycaprolactone/Calcium Peroxide Microparticles to Support Cell Survival in Hypoxic Environment....................................................................................................................................................................................................940

T. Kiratiwongwan, M. Zhang, W. Shen

Development and Optimization of Modular Self-Assembling Nucleopeptide-Based Scaffolds for Tissue Engineering Applications...............................................................................................................................................................................941

A. Noblett, K. Baek, L. Suggs

In vitro and in vivo Evaluation of Commercially Available Acellular Human Amniotic Membrane and Porcine Xenografts .......................................................................................................................................................................................................942

R. Early, H. Hewitt, H. Aberman

Gene Silencing Therapy for In Situ Elastic Matrix Regenerative Repair................................................................................................943S. Carney, T. Broekelmann, R. Mecham, A. Ramamurthi

Adipose Derived Mesenchymal Stem Cells Seeded on Biomimetic Polymer Scaffolds Induce Rapid Bone Regeneration Across a Large Segmental Bone Defect................................................................................................................................944

D. Margolis, D. Gonzales, J. Smith, J. Szivek

Proteoglycan/Gelatin Hydrogel via Enzymatic Gelation for Tissue Engineering Applications ............................................................945W.-B. Tsai, S. C. Ng, E. Bernotiene, A. Sobolev

The Differentiation Potential of Human Mesenchymal Stem Cell in Three-Dimensional Cues-integrated-biomaterials .....................................................................................................................................................................................................946

M. H. Park, R. Subbiah, K. Park, K. Lee

Design of Tissue-specific Extracellular Matrix Composite Hydrogels for Adipose-derived Stem/Stromal Cell Delivery ............................................................................................................................................................................................................947

A. Shridhar, B. Amsden, E. Gillies, L. Flynn

A Gradient Hierarchical Scaffold Induces in vivo Regeneration of Two Kinds of Tissues ...................................................................948S. Zhang, Y. Du, J. Wang

Novel Hybrid Hydrogels with Tunable Properties by Incorporating Polyethylene Glycol (PEG)-based Hydrogels for Tissue Engineering ...................................................................................................................................................................................949

J. Kim, B. Kim

3D Reconstruction through Two-Layered Tubular Scaffold and Bioreactor Cultivation in Circumferential Esophageal Defect...........................................................................................................................................................................................950

I. G. Kim, Y. Wu, H. Cho, J.-W. Shin, E.-J. Chung

Transfection of Dexamethasone-conjugated PEI Nanoparticles Complexed with pDNA and Shrna Controls Multilineage Differentiation of hMSCs ........................................................................................................................................................951

H. J. Kim, J. S. Park, K. H. Park, J. M. Park

Development of a Photocurable Shape Memory Polymer via Acrylation of Poly(glycerol dodecanoate)............................................952R. Akman, H. Ramaraju, S. Hollister

Predicting Vascularization in Porous Hydroxyapatite Scaffolds using a Computational Model..........................................................953E. Jui, S. Montelongo, T. Guda

Crosslinked Hyaluronan Hydrogels in Hyaluronan-Chitosan Capsules Synergize with Collagen I to Retain Secreted ECM and Promote MSC Chondrogenesis ...................................................................................................................................954

T. Alamin, C. Gabrion, H. Matthew

BIOPRINTABLE HYDROGELS FOR 3D TISSUE FABRICATION Mask Projection Microstereolithography (3D Printing) of Gelatin Methacrylate .................................................................................955

W. Surbey, N. Chartrain, A. Whittington

Shear-thinning, Thermally Responsive Poly(N-isopropylacrylamide)-based Bioink for 3D Bioprinting Applications .....................956Y. S. Kim, A. Navara, A. Chien, A. Mikos

Novel Enzymatically Cross-linked Silk Fibroin Bioink for Bioprinting of Patient-Specific Memory-Shape Implants for Meniscus Regeneration ............................................................................................................................................................................957

J. Costa, J. Silva-Correia, R. Reis, J. Oliveira

A Bioadhesive Hydrogel for Sealing and Treatment of Corneal Lacerations .........................................................................................958E. Shirzaei Sani, C. Jumelle, A. Kheirkhah, Y. Taketani, Z. Sun, R. Dana, N. Annabi

3D Printing Environmentally Responsive Medical Devices.......................................................................................................................959D. Cohn

Dual Crosslinking Strategy to Enhance the Mechanical Properties and Stability of Methacrylated Collagen Hydrogels.........................................................................................................................................................................................................960

N. Kajave, T.-U. Nguyen, V. Kishore

Development of Self-Assembling Peptide inspired Bioinks for Neural Tissue Engineering Applications ...........................................961M. Boyd-Moss, A. Quigley, K. Firipis, B. Long, D. Nisbet, R. Williams

3D Printing of Decellularised Porcine Lung ECM .....................................................................................................................................962S. Tas, D. A. Bölükbas, H. Alsafadi, D. E. Wagner

Polymers for Additive Manufacturing .........................................................................................................................................................963E. Alam, B. Treiber, G. Brokaw, B. Sewell, I. Lipe, B. Scammon, V. Reukov

Effect of a Cryogenic Build Platform on 3D Printed Hydrogel.................................................................................................................964L. Schultheis

The Tailored 3D-bioprinted Gelatin Scaffold Fabricated by Physical Cross-linked Without Chemical Cross-linking Agents...............................................................................................................................................................................................................965

C.-H. Kim, D. J. Choi, S. J. Park, S. Chung, C.-H. Kim

TISSUE ENGINEERING SIG Pre-differentiated Human Bone Marrow Stromal Cells and Platelet-rich Plasma Pretreated PLGA Scaffold for Meniscal Regeneration...................................................................................................................................................................................966

J. J. Yoo, H. J. Kim

Widespread Changes in Transcriptome Profile of Human Mesenchymal Stem Cells Induced by 2D Nanosilicates .........................967A. Gaharwar, J. Carrow, L. Cross, R. Reese, M. Jaiswal, C. Gregory, R. Kaunas, I. Singh

Recombinant Human Bone Morphogenetic Protein 2 Delivery from Tunable Keratin Biomaterials in a Critically-Sized Rat Femur Defect Model .....................................................................................................................................................................968

J. Saul, J. Bohnert, M. O'Brien, T. Carnwath, S. Alnuaimi, T. Smith

Developing A 3D Niche Microenvironment To Improve Stem Cell-Derived β-Cell Maturation For Treatment of Type 1 Diabetes ...............................................................................................................................................................................................969

R. Youngblood, D. Clough, C. Cras-Meneur, L. Shea

Development of Spiral Scaffolds with 3D Printing-based Combinatorial Technologies for Bone Tissue Engineering ......................970A. Kumar, X. Yu

X-ray Phase Contrast Imaging of Soft Biomaterials in a Whole-Animal Model ....................................................................................971J. Brown, S. Somo, F. Brooks, S. Komarov, W. Zhou, M. Anastasio, E. Brey

Vitamin C and B3 as New Biomaterials to Alter Intestinal Stem Cells.....................................................................................................972Y. Qi, J. Lohman, N. Peroutka-Bigus, B. Bellaire, M. Wannemuehler, Q. Wang, K.-J. Yoon, T. Barrett

Evaluation of Schwann Cells Proliferation on Heparin-collagen Layer-by-Layer Coatings.................................................................973L. C. Pinzon Herrera, J. Almodovar

Osteoinductive PolyHIPE Scaffolds as Improved Bone Void Fillers........................................................................................................974P. Dhavalikar, K. Salhadar, T. Wilems, D. Stahl, B. Saunder, E. Cosgriff-Hernandez

Engineering Vascularized Adipose Tissue Using Microvascular Fragments in Fibrin Hydrogels .......................................................975F. Acosta, K. Stojkova, E. Brey, C. Rathbone

ADDITIONAL PAPER Genetically Guided Engineering of Human Liver Tissue from Pluripotent Stem Cells.........................................................................976

M. Ebrahimkhani, J. Kilbourne, S. Kiani

Author Index