ISBN: 978-1-62748-128-1 ISSN: 1526-7547

Society for Biomaterials Annual Meeting and Exposition 2013 Biomaterials Revolution

Boston, Massachusetts, USA 10-13 April 2013

Volume 1 of 2

Transactions of the 37th Annual Meeting Volume XXXV

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Society For BiomaterialsTransactions of the 37th Annual MeetingVolume XXXV

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Table of Contents

Oral

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Cardiovascular Biomaterials

Long Term in vivo Study of Rapidly Degradable Synthetic Arterial GraftsR. A. Allen, University of Pittsburgh, Pittsburgh, PAW. Wu, Qindu Hospital, Fourth Military Medical University, Xi'an, ChinaM. Yao, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaD. Dutta, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PennsylvaniaX. Duan, University of Pittsburgh, Pittsburgh, PennsylvaniaT. N. Bachman, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaH. C. Champion, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaD. B. Stolz, University of Pittsburgh, Pittsburgh, PennsylvaniaA. M. Robertson, University of Pittsburgh, Pittsburgh, PennsylvaniaK. Kim, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PennsylvaniaJ. S. Isenberg, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaY. Wang, University of Pittsburgh, Pittsburgh, Pennsylvania

Bioactive anti-apoptotic coating: from 2D substrates to 3D commercial stent grafts for invivo testingP. Lequoy, Ecole de Technologie Superieure, Montreal, QC, CanadaM. Sbai, Ecole de Technologie Supérieure, Montreal, Québec, CanadaB. Saoudi, Ecole Polytechnique de Montreal, Montreal, Québec, CanadaA. Bertrand-Grenier, Universite de Montreal, Montreal, Québec, CanadaM. Wertheimer, Ecole polytechnique de Montreal, Montreal, Québec, CanadaG. Soulez, Universite de Montreal, Montreal, Québec, CanadaS. Lerouge, Ecole de technologie superieure, Montreal, Québec, Canada

Catheter-deliverable, Thermal and pH Responsive Hydrogels for Delivery of CardiacProgenitor Cells into Infarcted HeartsJ. Guan, The Ohio State University, Columbus, OH

Pro-angiogenic and Anti-inflammatory Biomaterial Therapies for Peripheral Artery DiseaseA. L. Zachman, Vanderbilt University, Nashville, TNJ. Ticker-Schwartz, Vanderbilt University, Nashville, TennesseeF. Shen, Vanderbilt University, Nashville, TennesseeS. Fitzpatrick, Vanderbilt University, Nashville, TennesseeM. Skala, Vanderbilt University, Nashville, TennesseeH. Sung, Vanderbilt University, Nashville, Tennessee

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Stacked collagen film enabled engineered small vascular graftY. Kim, University of Texas at Arlington, Arlington, TXS. Shah, University of Texas at Arlington, Arlington, TexasJ. Ahmed, University of Texas at Arlington, Arlington, Texas

Effects Of Electrical Stimulation and Insulin-like Growth Factor On Heart Cells Cultured OnA Microfabricated Degradable ElastomerH. Park, C.S. Draper Laboratory, Cambridge, MAB. L. Larson, MIT, Cambridge, MassachusettsM. E. Kolewe, MIT, Cambridge, MassachusettsG. Vunjak-Novakovic, Columbia University, New York, New YorkL. E. Freed, C.S. Draper Laboratory; MIT, Cambridge, Massachusetts

Mutli-Arm PEG Hydrogels Containing Collagen Sequence and Cell-Adhesive SequenceSupport Enzyme Mediated Degradation and Endothelial Cell ProliferationD. R. Jones, Case Western Reserve University, Cleveland Heights, OH

An Endothelium Simulating Multifunctional Nanomatrix for Drug Eluting StentsH. Jun, University of Alabama at Birmingham, Birmingham, ALA. Andukuri, University of Alabama at Birmingham, Birmingham, AlabamaY. Sohn, Emory University, Atlanta, GeorgiaY. Yoon, Emory University, Atlanta, GeorgiaB. Brott, University of Alabama at Birmingham, Birmingham, Alabama

Drug Delivery1

Injectable Scaffolds with Degradable Calcium Alginate Beads as a Cell Delivery System forTissue RepairR. Guo, Vanderbilt University, Nashville, TNC. L. Ward, United States Army Institute of Surgical Research, Fort Sam Houston, TexasS. A. Guelcher, Vanderbilt University, Nashville, Tennessee

Novel Sugar-Glass Nanoparticles system for Biomolecules Stabilization and Delivery inTissue Engineering Applicationsj. Giri, Parffenbarg Research Center,, Gaithersburg, MD

A pro-healing polyHEMA scaffold as an antibiotic-releasing insert for a scleral bandageA. Galperin, University of Washington, Seattle, WAK. Smith, University of Washington, Seattle, WashingtonJ. Bryers, University of Washington, Seattle, WashingtonT. Shen, University of Washington, Seattle, WashingtonB. Ratner, University of Washington, Seattle, Washington

Sequential drug delivery - in vitro and in vivoS. Sundararaj, University of Kentucky, Lexington, KYM. Thomas, University of Kentucky, Lexington, KentuckyM. Al-Sabbagh, University of Kentucky, Lexington, KentuckyT. Dziubla, University of Kentucky, Lexington, KentuckyD. Puleo, University of Kentucky, Lexington, Kentucky

Tunable Dual Growth Factor Delivery Using Multilayered Microparticles with ControllableDegradation Kinetics

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X. Yu, University of Wisconsin-Madison, Madison, WI

Development of a pH-responsive hydrogel network for the oral delivery of human growthhormoneS. D. Steichen, The University of Texas at Austin, Austin, TXN. Peppas, The University of Texas at Austin, Austin, Texas

Self-Assembled Micellar Complex Comprised of Green Tea Catechin Derivatives for ProteinDrug DeliveryS. Tan, Institute of Bioengineering and Nanotechnology, Singapore, Singapore

Controlled Protein Release from Layer-by-Layer Coated Hydrogel Scaffolds for Nerve RepairD. A. Lynam, Michigan State University, East Lansing, MID. Shahriari, Michigan State University, East Lansing, MichiganP. Angart, Michigan State University, East Lansing, MichiganK. Koffler, University of California-San Diego, La Jolla, CaliforniaC. Chan, Michigan State University, East Lansing, MichiganP. Walton, Michigan State University, East Lansing, MichiganM. Tuszynski, University of California-San Diego, La Jolla, CaliforniaJ. Sakamoto, Michigan State University, East Lansing, Michigan

Surface Characterization and Modification1

Nanofiber mediated osteoinduction through RhoA GTPase signalingT. Ozdemir, The Pennsylvania State University, University Park, PA

Nonfouling and Functionalizable Hydrogels based on Polyampholyte ChemistriesM. T. Bernards, University of Missouri, Columbia, MOM. Schroeder, University of Missouri, Columbia, MissouriD. E. McGrath, University of Missouri, Columbia, MissouriK. M. Zurick, University of Missouri, Columbia, Missouri

Studying the Synergistic Effect of Coatings and Nitric Oxide release on Platelet AdsorptionK. A. Amoako, University of Washington, Seattle, Seattle, WA

Surface Modification of a Poly(Glycolic-co-Lactic Acid) – Poly(DL-Lactide-co-Caprolactone)Small-Diameter Vascular Graft via CD34 Antibody Immobilization to Enhance CellAttachmentA. J. Melchiorri, University of Maryland, College Park, MDN. Hibino, Children's National Medical Center, District of Columbia, District of ColumbiaJ. P. Fisher, University of Maryland, College Park, Maryland

Migrating versus Stationary Applied Pressure Changes Lubricity of Hydrogel SurfacesA. C. Dunn, University of Florida, Gainesville, FLJ. Uruena, University of Florida, Gainesville, FloridaT. E. Angelini, University of Florida, Gainesville, FloridaW. Sawyer, University of Florida, Gainesville, Florida

Controlled End-functionality of Thermoresponsive Polymer Brushes for RegulatingThermally Induced Surface Cell Adhesion BehaviorN. MATSUZAKA, Tokyo University of Science, Chiba, JapanM. NAKAYAMA, Institure of Advanced Biomedical Engineering and Science, Tokyo Women's Medical

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University (TWIns), Tokyo, JapanH. TAKAHASHI, Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s MedicalUniversity (TWIns), Tokyo, JapanT. ASOH, Tokyo University of Science, Chiba, JapanA. KIKUCHI, Tokyo University of Science, Chiba, JapanT. OKANO, Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s MedicalUniversity (TWIns), Tokyo, Japan

Biofunctional Thermo-Responsive Polymeric Surface with Micropatterns for Controlling CellAttachment and DetachmentY. Kumashiro, Tokyo Women's Medical University, Tokyo, Japan

Silicone Elastomers with Intrinsic Control of Surface HydrophilicityJ. D. Goff, Gelest, Morrisville, PAB. Arkles, Gelest, Morrisville, Pennsylvania

Tissue Engineering1

Self-Assembly of Biomaterials for Bone Tissue MorphogenesisN. J. Shah, Massachusetts Institute of Technology, Cambridge, MAM. Hyder, Massachusetts Institute of Technology, Cambridge, MassachusettsM. Spector, Massachusetts Institute of Technology, VA Boston Healthcare System, Brigham andWomen's Hospital and Harvard Medical School, Boston, MassachusettsP. T. Hammond, Massachusetts Institute of Technology, Cambridge, Massachusetts

Biofabrication of Innervated Muscle Tissue for Accelerated Restoration of Muscle FunctionS. Lee, Wake Forest School of Medicine, Winston-Salem, NC

S1P Receptor Specific Drug Enhances Mandibular Defect Healing by Modulating LocalInflammation, Enhancing Neovascularization and Increasing Progenitor Cell Recruitment.A. Das, University of Virginia, Charlottesville, VAB. Hughley, University of Virginia, Charlottesville, VirginiaC. Segar, Gatech, Atlanta, GeorgiaE. Botchwey, Gatech, Atlanta, Georgia

Long-term static culture and fatigue testing of a bi-continuous hydrogel-elastomer scaffoldfor nucleus pulposus repairJ. W. S. Hayami, Queen's University, Kingston, ON, CanadaB. G. Amsden, Queen's University, Kingston, Ontario, CanadaS. D. Waldman, Queen's University, Kingston, Ontario, Canada

Co-culture Separation and Assembly by Nanotopographical Persuasion of CellsP. M. Reynolds, University of Glasgow, Glasgow, United Kingdom (Great Britain)R. H. Pedersen, University of Glasgow, Glasgow, United Kingdom (Great Britain)M. J. Dalby, University of Glasgow, Glasgow, United Kingdom (Great Britain)M. O. Riehle, University of Glasgow, Glasgow, United Kingdom (Great Britain)N. Gadegaard, University of Glasgow, Glasgow, United Kingdom (Great Britain)

3D Transdifferentiation of Human Mesenchymal Stem Cells into Hepatocyte-Like Cells UsingBioprinted ScaffoldsK. B. Chien, Northwestern University, Chicago, ILA. E. Jakus, Northwestern University, Chicago, Illinois

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R. N. Shah, Northwestern University, Chicago, Illinois

Human ECM Particles as an Injectable Bulking Agent for Adipose ReplacementA. Young, University of California, San Diego, La Jolla, CAT. McAllister, Cytograft, Inc, Novato, CaliforniaN. Dusserre, Cytograft, Inc, Novato, CaliforniaK. Christman, University of California, San Diego, La Jolla, CaliforniaN. L'Heureux, Cytograft, Inc., Novato, California

Fabrication of Vascularized 3D-Wound Healing Fibrous Tissues and Application for In VitroTumor Invasion ModelsA. Nishiguchi, Osaka University, Osaka, JapanM. Matsusaki, Osaka University, Osaka, JapanM. Akashi, Osaka University, Osaka, Japan

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Advances in Tissue Engineering Scaffolding

Spatial and Temporal Tuning of Synthetic Hydrogel Microenvironments for PromotingNeovascularizationG. Papavasiliou, Illinois Institute of Technology, Chicago, IL

Spatiotemporal Dissolved Oxygen Concentrations from a Nanofiber Cell Seeded ScaffoldD. T. Bowers, University of Virginia, Charlottesville, VAE. Botchwey, Georgia Tech, Atlanta, Georgia

Visible light-mediated multi-scale thiol-ene hydrogels for 3D cell cultureH. Shih, Indiana University-Purdue University Indianapolis, Indianapolis, INA. K. Fraser, Indiana University-Purdue University Indianapolis, Indianapolis, IndianaC. Lin, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana

Photodegradable Microspheres as Templates for Model Alveoli FormationK. J. R. Lewis, University of Colorado at Boulder, Boulder, COM. W. Tibbitt, University of Colorado at Boulder, Boulder, ColoradoK. S. Anseth, University of Colorado at Boulder, Boulder, Colorado

A Biomimetic PEG Hydrogel to Evaluate the Effects of a Vasculogenic Co-culture onHepatocyte BioactivityS. J. Higbee, Rice University, Houston, TXJ. L. West, Duke University, Houston, Texas

Aligned Conducting Polymer Nanotubes for On-Demand Release of Nerve Growth Factorand Contact Guidance of NeuronsM. R. Abidian, Pennsylvania State University, state College, PAG. Yang, Pennsylvania State University, State College, Pennsylvania

Design and Characterization of Porous Poly(Propylene Fumarate) Sleeve ScaffoldsM. O. Wang, University of Maryland College Park, College Park, MDC. E. Vorwald, University of Maryland, College Park, Maryland

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M. L. Dreher, Food and Drug Administration, Silver Spring, MD, MarylandE. J. Mott, Case Western Reserve University, Cleveland, OhioD. Dean, Case Western Reserve University, Cleveland, OhioJ. P. Fisher, University of Maryland, College Park, Maryland

Polycaprolactone Fumarate (PCLF) as a Backbone for Chondrocyte Attachment andProliferation Augmented by Platelet LysateD. Bravo, Mayo Clinic, Rochester, MNE. Wagner, Mayo Clinic, Rochester, MinnesotaD. Bravo, Mayo Clinic, Rochester, MinnesotaS. Chase, Mayo Clinic, Rochester, MinnesotaM. Dadsetan, Mayo Clinic, Rochester, MinnesotaS. Kakar, Mayo Clinic, Rochester, MinnesotaM. J. Yaszemski, Mayo Clinic, Rochester, Minnesota

Biomaterials for Modulating Immune and Inflammatory Processes

Modular B-cell and T-cell Epitope Assembly in a Peptide-based VaccineR. R. Pompano, University of Chicago, Chicago, ILJ. Chen, University of Chicago, Chicago, IllinoisE. A. Verbus, University of Chicago, Chicago, IllinoisA. S. Chong, University of Chicago, Chicago, IllinoisJ. H. Collier, University of Chicago, Chicago, Illinois

Tunable T cell immunity towards a protein antigen using polymersomes versus solid-corenanoparticlesE. Scott, Swiss Federal Institute of Technology (EPFL), Lausanne, SwitzerlandA. Stano, Ecole Polytechnique Federale de Lausanne, Lausanne, SwitzerlandK. Dane, Ecole Polytechnique Federale de Lausanne, Lausanne, SwitzerlandM. A. Swartz, Ecole Polytechnique Federale de Lausanne, Lausanne, SwitzerlandJ. A. Hubbell, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland

Finite Element Modeling of Strategies to Reduce the Foreign Body Response to NeuralElectrodes Chronically Implanted in Brain TissueN. F. Nolta, University of Utah, Salt Lake City, UTJ. L. Skousen, University of Utah, Salt Lake City, UtahM. B. Christensen, University of Utah, Salt Lake City, UtahP. A. Tresco, University of Utah, Salt Lake City, Utah

Long Term Survival of PEGylated Murine Allogenic Islets using Short CourseImmunomodulationJ. A. Giraldo, University of Miami, Miami, FLR. D. Molano, University of Miami, Miami, FloridaH. R. Rengifo, University of Miami, Miami, FloridaC. Fortino, University of Miami, Miami, FloridaC. Ricordi, University of Miami, Miami, FloridaA. Pileggi, University of Miami, Miami, FloridaC. L. Stabler, University of Miami, Miami, Florida

A dendritic cell-targeting microparticle vaccine for treatment of Type 1 DiabetesJ. S. Lewis, University of Florida, Gainesville, FLM. Carstens, University of Florida, Gainesville, Florida

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N. Dolgova, University of Florida, Gainesville, FloridaC. Xia, University of Florida, Gainesville, FloridaM. J. Clare-Salzler, University of Florida, Gainesville, FloridaB. G. Keselowsky, University of Florida, Gainesville, Florida

An Inflammation-responsive Hydrogel for Drug Delivery for Treatment of Ulcerative ColitisS. Zhang, Massachusetts Institute of Technology, Cambridge, MAS. Zhang, Massachusetts Institute of Technology, cambridge, MassachusettsJ. Ermann, Brigham and Women's Hospital, Boston, MassachusettsP. Vemula, Brigham and Women's Hospital, Cambridge, MassachusettsR. Langer, Massachusetts Institute of Technology, Cambridge, MassachusettsJ. M. Karp, Brigham and Women's Hospital, Cambridge, Massachusetts

Non-spherical Artificial Antigen Presenting Cells for Tumor ImmunotherapyJ. C. Sunshine, Johns Hopkins School of Medicine, Baltimore, MDK. Perica, Johns Hopkins School of Medicine, Baltimore, MarylandJ. P. Schneck, Johns Hopkins School of Medicine, Baltimore, MarylandJ. J. Green, Johns Hopkins School of Medicine, Baltimore, Maryland

Neutrophil extracellular traps on biomaterials?C. Sperling, Leibniz-Institute of Polymer Research Dresden, Dresden, GermanyM. Fischer, Leibniz-Institute of Polymer Research Dresden, Dresden, GermanyC. Werner, Leibniz-Institute of Polymer Research Dresden, Dresden, Germany

Ceramics and Composites in Bone Tissue Engineering and Drug Delivery

Effects of Hydroxyapatite-Coating vs. Hydrophilic Surface on Early Healing of DentalImplant in an Ovine ModelJ. Lee, Zimmer Dental Inc., Carlsbad, CAH. Wen, Zimmer Dental Inc., Carlsbad, CaliforniaJ. Bassett, Zimmer Dental Inc., Carlsbad, California

SiO2 and ZnO Dopants in 3D Printed TCP Scaffolds Enhances Osteogenesis andAngiogenesis in vivoS. Bose, Washington State University, Pullman, WAG. Fielding, Washington state university, Pullman, Washington

Fully Dense Nanocrystalline Hydroxyapatite as a Structural Material for Spinal InterbodyFusionA. K. MacMillan, Pioneer Surgical Technology, Woburn, MAL. Ferrara, Orthokinetic Technologies, Southport, North CarolinaT. J. Webster, Northeastern University, Boston, MassachusettsJ. Timothy, Spire Leeds Hosptial, Leeds, United Kingdom (Great Britain)E. Ahn, N/A, Dover, Massachusetts

Injectable Polymer/β-TCP Biocomposite Delivery Systems for rhBMP-2A. D. Talley, Vanderbilt University, Nashville, TNE. M. Prieto, Vanderbilt University, Nashville, TennesseeK. J. Zienkiewicz, Vanderbilt University, Nashville, TennesseeT. Guda, University of Texas at San Antonio, Fort Sam Houston, TexasP. Brown Baer, USAISR, Fort Sam Houston, TexasD. T. Silliman, USAISR, Fort Sam Houston, Texas

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S. A. Guelcher, Vanderbilt University, Nashville, Tennessee

Size Matters: Effects of PLGA-Microsphere Size in Injectable CPC/PLGA on Bone FormationJ. van den Beucken, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

Evaluation of a Gentamicin-Loaded Hydroxyapatite/Chitin Bone CementH. A. Doty, University of Memphis, Memphis, TNR. Hay, Singapore General Hospital, Singapore, SingaporeT. H. Ong, National Cancer Center, Singapore, SingaporeH. M. Kam, National Cancer Center, Singapore, SingaporeA. K. S. Yew, Singapore General Hospital, Singapore, SingaporeC. M. Guo, Singapore General Hospital, Singapore, Singapore

Strontium Doped Calcium Phosphate Coatings on Biodegradable Magnesium AlloysS. S. Singh, University of Pittsburgh, Pittsburgh, PAA. Roy, University of Pittsburgh, Pittsburgh, PennsylvaniaB. Lee, University of Pittsburgh, Pittsburgh, PennsylvaniaP. N. Kumta, University of Pittsburgh, Pittsburgh, Pennsylvania

Effect of Local Alendronate Delivery on In Vivo Osteogenesis From PCL Coated 3D PrintedTCP ScaffoldsS. Bose, Washington State University, Pullman, WAS. Tarafder, Washington State University, Pullman, Washington

Drug Delivery2-Cancer

Sodium Citrate Stabilized Calcium Phosphate Nanoparticles for the Sustained Delivery ofCisplatinE. E. Jacobs, University of Connecticut Health Center, Farmington, CTJ. L. Woodman, University of Connecticut Health Center, Farmington, ConnecticutL. T. Kuhn, University of Connecticut Health Center, Farmington, Connecticut

A Novel In-Situ Forming Calcium Polyphosphate System for Anti-Cancer Drug ReleaseA. Momeni, School of Biomedical Engineering, Dalhousie University, Halifax, NS, Canada

DEVELOPMENT OF A NOVEL TARGETED MICROPARTICLE DRUG DELIVERY SYSTEM FORCANCER MEDICATIONC. E. Clark, Villanova University, Bryn Mawr, PA

Mimicking Platelet-Cancer Cell Interactions for Targeted Drug Delivery in Metastatic BreastCancerC. Modery-Pawlowski, Case Western Reserve University, Cleveland, OHA. Master, Case Western Reserve University, Cleveland, OhioV. Pan, Case Western Reserve University, Cleveland, OhioG. P. Howard, Case Western Reserve University, Cleveland, OhioA. Sen Gupta, Case Western Reserve University, Cleveland, Ohio

Biomaterial-mediated cancer-specific DNA delivery to liver cell cultures using syntheticpoly(beta-amino esters)S. Y. Tzeng, Johns Hopkins University School of Medicine, Baltimore, MDL. J. Higgins, Johns Hopkins University School of Medicine, Baltimore, MarylandM. G. Pomper, Johns Hopkins University School of Medicine, Baltimore, Maryland

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J. J. Green, Johns Hopkins University School of Medicine, Baltimore, Maryland

Molecular Farming and Engineering of a Filamentous Platform Technology to DeliverTherapies to Breast CancerK. L. Lee, Case Western Reserve University, Cleveland Heights, OHS. Shukla, Case Western Reserve University, Cleveland, OhioK. L. Lozada, Case Western Reserve University, Cleveland, OhioR. A. Keri, Case Western Reserve University, Cleveland, OhioN. F. Steinmetz, Case Western Reserve University, Cleveland, Ohio

Design of a Drug Eluting Stent for treatment of pancreatic malignancyL. Indolfi, Massachusetts Institute of Technology, Cambridge, MAM. Ligorio, Massachusetts General Hospital, Boston, MassachusettsD. Ting, Massachusetts General Hospital, Charlestown, MassachusettsC. Ferrone, Massachusetts General Hospital, Boston, MassachusettsJ. W. Clark, Massachusetts General Hospital, Boston, MassachusettsR. Langer, Massachusetts Institute of Technology, Cambridge, MassachusettsE. R. Edelman, Massachusetts Institute of Technology, Cambridge, Massachusetts

Intrinsically radiopaque porous microspheres for improved transarterialchemoembolizationK. Saralidze, Maastricht University, Maastricht, Netherlands

Implant Pathology

Biocompatibility and degradation behavior of Mg-Sr alloy as temporary cardiovascularimplantsM. Bornapour, McGill University, Montreal, QC, CanadaM. Cerruti, McGill University, Montreal, Québec, CanadaD. Shum-Tim, McGill University, Montreal, Québec, CanadaM. Pekguleryuz, McGill University, Montreal, Québec, Canada

Evaluation of Failure Mechanisms of Utah Electrode Arrays in Rat CortexM. B. Christensen, University of Utah, Salt Lake City, UTN. F. Nolta, University of Utah, Salt Lake City, UtahJ. L. Skousen, University of Utah, Salt Lake City, UtahP. A. Tresco, University of Utah, Salt Lake City, Utah

Histological and Clinical Evaluation of Failed Shoulder Surface Replacement ImplantsS. Ajami, UCL, Stanmore , Middlesex, United Kingdom (Great Britain)M. Coathup, UCL, Stanmore, Middlesex, United Kingdom (Great Britain)R. Olley, UCL, Stanmore, Middlesex, United Kingdom (Great Britain)C. Wek, UCL, Stanmore, Middlesex, United Kingdom (Great Britain)B. Bonnaud, UCL, Stanmore, Middlesex, United Kingdom (Great Britain)S. Alexander, Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom (GreatBritain)S. Lambert, Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom (GreatBritain)C. Kelly, The Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, United Kingdom (GreatBritain)G. Blunn, UCL, Stanmore, Middlesex, United Kingdom (Great Britain)

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Metal Bearing Surfaces in Total Joint Arthroplasty: Do different joints display similardamage modes?F. Ansari, University of California, Berkeley, Berkeley, CAE. Alvarez, Clemson University, Greenville, South CarolinaM. Harman, Clemson University, Clemson, South CarolinaL. Pruitt, University of California, Berkeley, Berkeley, CaliforniaM. Mayor, Dartmouth College, Hanover, New HampshireD. W. Van Citters, Dartmouth College, Hanover, New Hampshire

Investigating Keratin as a Biomimetic Coating for Percutaneous Device ApplicationsS. Jeyapalina, University of Utah, Salt Lake City, UTM. Van Dyke, Virginia Polytechnic Institute and State University, Blacksburg, VirginiaA. Sampson, Virginia Polytechnic Institute and State University, Blacksburg, VirginiaD. H. Betz, University of Utah, Salt Lake City, UtahR. D. Bloebaum, University of Utah, Salt Lake City, Utah

In vivo evaluation of device-associated inflammation using Positron Emission TomographyImagingJ. ZHOU, University of Texas at Arlington, Arlington, TXG. Hao, University of Texas Southwestern Medical Center, Dallas, TexasH. Weng, University of Texas at Arlington, Arlington, TexasY. Tsai, University of Texas at Arlington, Arlington, TexasD. W. Baker, University of Texas at Arlington, Arlington, TexasX. Sun, University of Texas Southwestern Medical Center, Dallas, TexasL. Tang, University of Texas at Arlington, Arlington, Texas

Proteins and Cells at Interfaces

Atomic Force Microscopy Study of Coagulation Factor XII Interaction with Factor XIAutoactivation on Hydrophilic and Hydrophobic SurfacesL. Xu, Penn State College of Medicine, Hershey, PAC. Siedlecki, Penn State College of Medicine, Hershey, Pennsylvania

Adhesion o VM. Rusin, Clemson University, Clemson, SCY. Mei, Clemson University, Charleston, South CarolinaD. Dean, Clemson University, Clemson, South Carolina

Elastomer Crosslink Density Affects Protein Adsorption and ConformationM. C. Vyner, Queen's University, Kingston, ON, CanadaL. Liu, McMaster University, Hamilton, Ontario, CanadaH. D. Sheardown, McMaster University, Hamilton, Ontario, CanadaB. G. Amsden, Queen's University, Kingston, Ontario, Canada

Preparation and Characterization of Collagen Substrates for Protein Interactions StudiesD. G. Castner, University of Washington, Seattle, WAE. H. Tronic, University of Washington, Seattle, WashingtonR. Foster, University of Washington, Seattle, WashingtonP. Koelsch, University of Washington, Seattle, Washington

Poly(trimethylene carbonate) Molecular Weight Affects Enzymatic Adsorption andConformation, and Macrophage Behavior

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M. C. Vyner, Queen's University, Kingston, ON, CanadaA. Li, Queen's University, Kingston, Ontario, CanadaB. G. Amsden, Queen's University, Kingston, Ontario, Canada

Initial Cell Adhesion on RGD-immobilized Phospholipid Polymer Brush Layer with DifferentMolecular MobilityY. Inoue, The University of Tokyo, Tokyo, JapanY. Onodera, The University of Tokyo, Toyko, JapanK. Ishihara, The University of Tokyo, Tokyo, Japan

Endothelial Cell Selective Surface for Modifying ePTFE GraftsL. Dudash, Case Western Reserve University, Cleveland, OHF. Kligman, Cleveland Clinic, Cleveland, OhioK. Kapalka, Case Western Reserve University, Cleveland, OhioK. Kottke-Marchant, Cleveland Clinic, Cleveland, OhioR. Marchant, Case Western Reserve University, Cleveland, Ohio

Interactions of Escherichia coli HM22 Biofilm with Electrochemically Active CommerciallyPure Titanium SurfaceJ. Guo, Syracuse University, Syracuse, NYJ. L. Gilbert, Syracuse University, Syracus, New York

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Advances in Ophthalmic Biomaterials and Ocular Drug-Delivery1

Enhanced Coated Hydrogel Device for Controlled Release of Drugs for Cataract SurgeryF. B. Karp, University of Washington, Seattle, WAN. Geisler, University of Washington, Seattle, WashingtonS. Garty, University of Washington, Seattle, WashingtonT. T. Shen, University of Washington, Seattle, WashingtonB. D. Ratner, University of Washington, Seattle, Washington

Sustained Release of Bevacizumab Using an Injectable, Degradable and BiocompatibleReverse Thermal GelB. M. Rauck, University of Pittsburgh, Pittsburgh, PAC. Medina, University of Pittsburgh, Pittsburgh, PennsylvaniaT. R. Friberg, University of Pittsburgh, Pittsburgh, PennsylvaniaY. Wang, University of Pittsburgh, Pittsburgh, Pennsylvania

Optimized Properties of Collagen Vitrigel Membranes for Ocular Repair and RegenerationApplicationsX. Caldron-Colon, The Johns Hopkins University Applied Physics Laboratory, Laurel, MDZ. Xia, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandJ. L. Breidenich, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandD. Mulreany, The Whitaker Biomedical Engineering Institute at Johns Hopkins University School ofMedicine, Baltimore, MarylandQ. Guo, The Whitaker Biomedical Engineering Institute at Johns Hopkins University School ofMedicine, Baltimore, MarylandM. Uy, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

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J. Tiffany, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandD. E. Freund, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandR. L. McCally, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandO. Schein, The Wilmer Eye Institute Johns Hopkins Hospital, Baltimore, MarylandJ. H. Elisseeff, The Whitaker Biomedical Engineering Institute at Johns Hopkins University School ofMedicine, Baltimore, MarylandM. M. Trexler, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

The Monthly Eye Drop: Development of a Long-term, Noninvasive Glaucoma TreatmentSystemM. V. Fedorchak, University of Pittsburgh, Pittsburgh, PAA. Cugini, University of Pittsburgh, Pittsburgh, PennsylvaniaJ. S. Schuman, Unversity of Pittsburgh, Pittsburgh, PennsylvaniaS. R. Little, University of Pittsburgh, Pittsburgh, Pennsylvania

Extended Ocular Drug Delivery using Hyaluronic Acid-containing model Silicone HydrogelMaterialsM. Korogiannaki, McMaster University, Hamilton, ON, Canada

Evaluating the Relationship Between Transparent Hydrogel Chemistry and DexamethasoneDeliveryG. Guidi, McMaster University, Hamilton, ON, Canada

Nanogels for Sustained Ocular Delivery of Brimonidine for Treatment of GlaucomaD. R. Janagam, University of Tennessee Health Science Center, memphis, TNL. Wu, University of Tennessee Health Science Center, Memphis, TennesseeJ. Zhang, Henan Eye Institute, Zhengzhou, ChinaT. Lowe, University of Tennessee Health Science Center, Memphis, Tennessee

Hyaluronic Acid-Based Hydrogels as Scaffolds for Stem Cells to Differentiate Into NeuronalCellsK. Compton, University of Tennessee Health Science Center, Memphis, TNL. Wu, University of Tennessee Health Science Center, Memphis, TennesseeT. Lowe, University of Tennessee Health Science Center, Memphis, Tennessee

Advances in Polymeric Nano-/Microparticle Formulation Techniques

A New Green Route to Prepare Stimuli-responsive Hydrogel Particles: Integrating EpoxyChemistry with Thermal Induced Phase SeparationW. He, University of Tennessee, Knoxville, Knoxville, TNS. Tang, University of Tennessee, Knoxville, Knoxville, TennesseeZ. Shi, University of Tennessee, Knoxville, Knoxville, Tennessee

Hydrogel-Nanoshell Composite Materials for Therapeutic DeliveryL. E. Strong, Duke University, Durham, NCS. N. Dahotre, Duke University, Durham, North CarolinaJ. L. West, Duke University, Durham, North Carolina

Preparation of Micrcogels Using Thiol-Ene “Click” ChemistryA. K. Fraser, Indiana University Purdue University at Indianapolis, Indinapolis, INH. Shih, Indiana University Purdue University at Indianapolis, Indianapolis, IndianaC. Lin, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana

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A Cell-targeted Photodynamic Nanomedicine Strategy for Head & Neck CancersA. M. Master, Case Western Reserve University, Cleveland, OHA. Malamas, Case Western Reserve University, Cleveland, OhioR. Solanki, Case Western Reserve University, Cleveland, OhioD. M. Clausen, University of Pittsburgh Medical Center, Pittsburgh, PennsylvaniaJ. L. Eiseman, University of Pittsburgh Medical Center, Pittsburgh, PennsylvaniaA. Sen Gupta, Case Western Reserve University, Cleveland, Ohio

Study on the Novel Drug Vehicle for Encapsulation of Hydrophobic Agent and MR ImagingH. Chen, National Yang-Ming University, Taipei, TaiwanT. Liu, National Yang-Ming University, Taipei, Taiwan

Modulation of Polymer/DNA Release from Poly(lactic-co-glycolic acid) Microspheresthrough Poly(ethylenimine) Modification and Loading ConcentrationC. J. Needham, Rice University, Houston, TXS. Shah, Rice University, Houston, TexasF. Kasper, Rice University, Houston, TexasA. G. Mikos, Rice University, Houston, Texas

Array of Biodegradable Microelements for Isolation and Implantation of Living, AdherentCellsY. Wang, University of North Carolina, Chapel Hill, Chapel Hill, NC

Preparation of Chitosan-Coated Magnetite Nanoparticles and Application for Immobilizationof LaccaseE. Aksoy, Middle East Technical University, Ankara, TurkeyS. Aksoy, Gazi University, Ankara, TurkeyN. Kalkan, Gazi University, Ankara, TurkeyN. Hasirci, Middle East Technical University, Ankara, Turkey

Biologically Inspired Biomaterials Approaches for Cancer Research

A Biomimetic Hydrogel System to Study Tumor AngiogenesisL. C. Roudsari, Duke University, Durham, NCB. J. Gill, Rice University, Houston, TexasD. L. Gibbons, The University of Texas MD Anderson Cancer Center, Houston, TexasJ. M. Kurie, The University of Texas MD Anderson Cancer Center, Houston, TexasJ. L. West, Duke University, Durham, North Carolina

Cancer-activated adipocytes and their role in extracellular matrix remodeling andangiogenesisB. Seo, Cornell University, Ithaca, NYJ. Gonzalez, Cornell University, Ithaca, New YorkS. Moore, Cornell University, Ithaca, New YorkL. T. Vahdat, Weill Cornell Medical College, New York, New YorkC. Fischbach, Cornell University, Ithaca, New York

Elucidating the Role of Microenvironmental Cues on Melanoma Drug ResistanceE. Y. Tokuda, The BioFrontiers Institute and the Howard Hughes Medical Institute,University of Colorado, Boulder, COJ. L. Leight, The BioFrontiers Institute and the Howard Hughes Medical Institute, University of

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Colorado, Boulder, ColoradoK. S. Anseth, The BioFrontiers Institute and the Howard Hughes Medical Institute, University ofColorado, Boulder, Colorado

Engineering extracellular matrix constructs to modulate endothelial cell secretion and itsability to control cancer.J. L. Dreyfuss, Massachusetts Institute of Technology, Cambridge, MA

Combination of Pathogen-mimicking Polymer Particles and an Injectable, SyntheticImmune-Priming Center (sIPC) Significantly Enhances Cellular and Protective Immunity inMurine Models of CancerP. Pradhan, The University of Texas at Austin, Austin, TX

Engineered 3D matrices to study regulation of glioblastoma cell malignancyS. Pedron, University of Illinois at Urbana-Champaign, Urbana, ILE. Becka, University of Illinois at Urbana-Champaign, Urbana, IllinoisE. Roy, University of Illinois at Urbana-Champaign, Urbana, IllinoisB. Harley, University of Illinois at Urbana-Champaign, Urbana, Illinois

Biomaterials for Cardiac Repair

Extracellular matrix hydrogel as growth factor delivery system for prolonged release andenhanced effect of a novel engineered HGF mimic in a small animal model of myocardialinfarctionS. Sonnenberg, University of California, San Diego, San Diego, CA

Sustained Release of SDF-1α Polypeptide Analogue from Hyaluronic Acid Hydrogels forCardiac RepairB. P. Purcell, University of Pennsylvania, Philadelphia, PAJ. W. MacArthur, Jr., University of Pennsylvania, Philadelphia, PennsylvaniaJ. Y. Woo, University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Injectable Poly(Vinyl Alcohol) Hydrogels for Cardiovascular ApplicationsG. J. Braithwaite, Cambridge Polymer Group, Boston, MAT. Wilson-Hill, Cambridge Polymer Group, Boston, MassachusettsJ. Hung, Massachusetts General Hospital, Boston, Massachusetts

Examining the Influence of Injectable Hyaluronic Acid Hydrogels on Myocardial InfarctRepair using MRIS. M. Dorsey, University of Pennsylvania, Philadelphia, PAE. Tous, University of Pennsylvania, Philadelphia, PennsylvaniaJ. R. McGarvey, University of Pennsylvania, Glenolden, PennsylvaniaJ. F. Wenk, University of Kentucky, Lexington, KentuckyJ. H. Gorman, III, University of Pennsylvania, Glenolden, PennsylvaniaR. C. Gorman, University of Pennsylvania, Glenolden, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Integration of Cysteine-rich angiogenic inducer 61 (CYR61) into collagen biomaterialpromotes the therapeutic potential of circulating angiogenic cellsB. McNeill, University of Ottawa Heart Institute, Ottawa, ON, CanadaB. Vulesevic, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

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M. Ruel, University of Ottawa Heart Institute, Ottawa, Ontario, CanadaE. J. Suuronen, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Hydrogels Designed to Provide Sustained, Stimuli-Responsive Release of Pro-AngiogenicPeptidesA. H. Van Hove, University of Rochester, Rochester, NYD. Benoit, University of Rochester, Rochester, New York

Orthopaedic Biomaterials1

In Vivo Remodeling of 45S5 Bioactive Glass/Polyurethane Biocomposites with Initial Bone-like Mechanical PropertiesA. J. Harmata, Vanderbilt University, Nashville, TNC. L. Ward, United States Army Institute of Surgical Research, Fort Sam Houston, TexasK. J. Zienkiewicz, Vanderbilt University, Nashville, TennesseeJ. C. Wenke, United States Army Institute of Surgical Research, Fort Sam Houston, TexasS. A. Guelcher, Vanderbilt University, Nashville, Tennessee

Polyvinyl alcohol-polyacrylic acid (PVA-PAA) hydrogels for osteochondral defect repairD. Bichara, Massachusetts General Hospital, Boston, MAH. Bodugoz-Senturk, Massachusetts General Hospital, Boston, MassachusettsD. Ling, Massachusetts General Hospital, Boston, MassachusettsE. Malchau, Massachusetts General Hospital, Boston, MarylandC. Bragdon, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

One Year Evaluation of a PCL-TCP Putty in an Ovine Critical Sized Metaphyseal DefectModel.S. Woods, DePuy Synthes, West Chester, PAA. Petticoffer, DePuy Synthes, West Chester, PennsylvaniaP. Patel, DePuy Synthes, West Chester, PennsylvaniaD. Arens, AO Research Institute, Davos, Switzerland

Ultrasound As a Physical Force for Enhanced Scaffold-Based Bone RepairJ. Veronick, University of Connecticut, Farmington, CTY. Khan, University of Connecticut, Farmington, ConnecticutB. Huey, University of Connecticut, Storrs, ConnecticutY. Kutes, Institute of Materials Science, Storrs, Connecticut

Rapid vascularization and anastomosis of a large vascularized construct of collagen/β-TCPscaffold fabricated by template-casting and electrochemical detachment techniqueY. Kang, Stanford University, Stanford, CAN. Mochizuki, University of Tsukuba, Tsukuba, Ibaraki, JapanL. Ren, Lanzhou University, Lanzhou,Gansu, ChinaA. Khademhosseini, Harvard Medical School, Cambridge, MassachusettsJ. Fukuda, University of Tsukuba, Ibaraki, JapanY. Yang, Stanford University, Stanford, California

Biomechanical Evaluation of an Injectable and Biodegradable Copolymer P(PF-co-CL) in aCadaveric Vertebral Body Defect ModelZ. Fang, Mayo Clinic, Rochester, MN

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Novel Silk-Calcium Phosphate Ceramic Scaffolds for Bone Tissue EngineeringS. L. McNamara, Tufts University, Medford, MAD. L. Kaplan, Tufts University, Medford, MassachusettsT. J. Lo, Tufts University, Medford, Massachusetts

Investigation of Mesenchymal Stem Cell Phenotype and Function in an Allograft CellularBone MatrixL. S. Brown, Stryker, Corp., Malvern, PAM. M. Darmoc, Stryker, Corp., Malvern, PennsylvaniaT. D. Clineff, Stryker, Corp., Malvern, Pennsylvania

Patterning Microenvironments for Tissue Engineering and Morphogenesis

Micro-contact Printing of Viable Tissues via Geometrically Patterned Shape-ShiftingSupportsO. O. Akintewe, University Of South Florida, Tampa, FLS. J. DuPont, University Of South Florida, Tampa, FloridaR. G. Toomey, University Of South Florida, Tampa, FloridaN. D. Gallant, University Of South Florida, Tampa, Florida

Integrating Mechanical Cues and Biomolecular Patterns in a Collagen-GlycosaminoglycanScaffold for Tendon-Bone Junction RepairL. Mozdzen, University of Illinois at Champaign-Urbana, Champaign, IL

Development and Characterization of a High-Throughput Screening Surface CombiningGeometric and Nanotopographical Mechanical Cues to Investigate Cell-Surface InteractionsN. J. Steinmetz, University of Glasgow, Glasgow, United Kingdom (Great Britain)M. J. Dalby, University of Glasgow, Glasgow, United Kingdom (Great Britain)N. Gadegaard, University of Glasgow, Glasgow, United Kingdom (Great Britain)

Real-time Measurement of Intercellular Stresses in Cells Grown on MicropatternsK. Suffoletto, SUNY Buffalo, Buffalo, NY

Application of rapid prototyping to high throughput screening of 3D dynamic environmentsP. F. Costa, University of Minho, Guimarães, PortugalC. Vaquette, Queensland University of Technology, Brisbane, AustraliaC. Theodoropoulos, Queensland University of Technology, Brisbane, AustraliaM. E. Gomes, University of Minho, Guimarães, PortugalR. L. Reis, University of Minho, Guimarães, PortugalD. W. Hutmacher, Queensland University of Technology, Brisbane, Australia

A Novel Endothelial Cell Scaffold for Small-Diameter Vascular EngineeringK. J. McHugh, Boston University; Schepens Eye Research Institute; The Charles StarkDraper Laboratory, Inc., Boston, MAS. L. Tao, The Charles Stark Draper Laboratory, Inc.; CooperVision, Inc., Cambridge, MassachusettsM. Saint-Geniez, Schepens Eye Research Institute; Harvard Medical School, Boston, Massachusetts

Effect of PGS-PCL Electrospun Fibers Orientation on Alignment and Proliferation of HumanUmbilical Vein Endothelial CellsA. Gaharwar, Massachusetts Institute of Technology, Cambridge, MAM. Nikkhah, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsS. Sant, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, Massachusetts

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A. Patel, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsS. Mihaila, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsA. Khademhosseini, Brigham and Women’s Hospital, Harvard Medical School, Cambridge,Massachusetts

3D Patterned Microenvironments Created through Assembly of Discrete Collagen-ChitosanTissue ModulesD. J. Caldwell, University of Michigan, Ann Arbor, MID. J. Caldwell, University of Michigan, Ann Arbor, MichiganR. R. Rao, University of Michigan, Ann Arbor, MichiganJ. P. Stegemann, University of Michigan, Ann Arbor, Michigan

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Advances in Ophthalmic Biomaterials and Ocular Drug-Delivery2

Corneal Stromal Stem Cells Versus Corneal Fibroblasts in Generating StructurallyAppropriate Corneal Stromal TissueJ. Wu, University of Pittsburgh School of Medicine, Pittsburgh, PAY. Du, University of Pittsburgh School of Medicine, Pittsburgh, PA, PennsylvaniaJ. L. Funderburgh, University of Pittsburgh School of Medicine, Pittsburgh, PennsylvaniaW. R. Wagner, University of Pittsburgh, Pittsburgh, Pennsylvania

Engineered Basement Membranes for Regeneration of the Corneal EndotheliumA. W. Feinberg, Carnegie Mellon University, Pittsburgh, PAR. N. Palchesko, Carnegie Mellon University, Pittsburgh, PennsylvaniaO. Creasey, University of Pittsburgh, Pittsburgh, PennsylvaniaJ. L. Funerburgh, University of Pittsburgh, Pittsburgh, Pennsylvania

Chemical modification of hyaluronan: Improving hyaluronan as a wetting agent for contactlenses.S. Paterson, McMaster University, Hamilton, ON, Canada

Phenylboronic Acid Modified Mucoadhesive Hydrogel Materials for Ophthalmic Drug deliveryApplicationsL. Liu, McMaster University, Canada, Hamilton, ON, CanadaH. D. Sheardown, McMaster University, Canada, Hamilton, Ontario, Canada

Poly(Ethylene Glycol)-Hyaluronic Acid Antioxidant Hydrogels for Prevention of IatrogenicCataractsM. G. O'Toole, University of Louisville, Louisville, KYR. M. Rostosky, University of Louisville, Louisville, KentuckyT. H. Tezel, University of Louisville, Louisville, KentuckyA. S. Gobin, University of Louisville, Louisville, Kentucky

Effect of E-Beam Sterilization on Optical and Rheological Properties of Some ViscoelasticProductsC. B. Hu, Abbott Medical Optics, Santa Ana, CAH. Powell, Abbott Medical Optics, Santa Ana, California

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Advances in Tissue Engineering Scaffolding2

Gelatin methacrylate (GelMA) and agarose hydrogels as a smart platform for bioprintingbiomimetic vascular networks in 3D tissue engineering constructsL. E. Bertassoni, Center for Biomedical Engineering, Department of Medicine, Brigham andWomen’s Hospital, Harvard Medical School; Harvard-MIT Division of Health Sciences andTechnology, Massachusetts Institute of Technology; Faculty of Dentistry, University ofSydney, Aus, Cambridge, MAM. Cecconi, 1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women’sHospital, Harvard Medical School; 2. Harvard-MIT Division of Health Sciences and Technology,Massachusetts Institute of Technology;, Cambridge, MassachusettsP. H. Molin, 1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women’sHospital, Harvard Medical School; 2. Harvard-MIT Division of Health Sciences and Technology,Massachusetts Institute of Technology;, Cambridge, MassachusettsE. S. Martinez-Martinez, 1. Center for Biomedical Engineering, Department of Medicine, Brigham andWomen’s Hospital, Harvard Medical School; 2. Harvard-MIT Division of Health Sciences andTechnology, Massachusetts Institute of Technology, Cambridge, MassachusettsM. Nikkhah, 1. Center for Biomedical Engineering, Department of Medicine, Brigham and Women’sHospital, Harvard Medical School; 2. Harvard-MIT Division of Health Sciences and Technology,Massachusetts Institute of Technology, Cambridge, MassachusettsA. Khademhosseini, Center for Biomedical Engineering, Department of Medicine, Brigham andWomen’s Hospital, Harvard Medical School; Harvard-MIT Division of Health Sciences andTechnology, Massachusetts Institute of Technology; Wyss Institute for Biologically Inspired Engin,Cambridge, Massachusetts

Design and Analysis of Flexible Composite Scaffolds for Engineered EarT. M. Cervantes, Massachusetts General Hospital, Boston, MAE. K. Bassett, Massachusetts General Hospital, Boston, MassachusettsA. Tseng, Massachusetts General Hospital, Boston, MassachusettsA. Kimura, Massachusetts General Hospital, Boston, MassachusettsN. Roscioli, Kensey Nash Corporation, Exton, PennsylvaniaR. Gupta, Massachusetts General Hospital, Boston, MassachusettsM. A. Randolph, Massachusetts General Hospital, Boston, MassachusettsJ. P. Vacanti, Massachusetts General Hospital, Boston, MassachusettsI. Pomerantseva, Massachusetts General Hospital, Boston, MassachusettsC. A. Sundback, Massachusetts General Hospital, Boston, Massachusetts

Controllably degradable self-assembling peptide materials for tissue engineeringY. F. Tian, University of Chicago, Chicago, IL

Formation of Endothelial Cell Networks in Hydrogel Scaffolds Assembled from ModularCollagen-Fibrin MicroenvironmentsA. W. Peterson, University of Michigan, Ann Arbor, MIA. W. Peterson, University of Michigan, Ann Arbor, MichiganR. R. Rao, University of Michigan, Ann Arbor, MichiganA. Y. Rioja, University of Michigan, Ann Arbor, MichiganA. J. Putnam, University of Michigan, Ann Arbor, MichiganJ. P. Stegemann, University of Michigan, Ann Arbor, Michigan

Scaffold pore size controls chondrogenic differentiation of human mesenchymal stem cellsand cartilage formation in vitro and in vivoM. J. Gupte, University of Michigan, Ann Arbor, MI

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J. Hu, University of Michigan, Ann Arbor, MichiganH. Ma, University of Michigan, Ann Arbor, MichiganG. Feng, University of Michigan, Ann Arbor, MichiganK. Feng, University of Michigan, Ann Arbor, MichiganG. Xiao, University of Michigan, Ann Arbor, MichiganP. X. Ma, University of Michigan, Ann Arbor, Michigan

Novel Porous Polycaprolactone Fumarate (PCLF) Scaffold for Adipocyte DerivedMesenchymal Stem Cell Engineering and Platelet Lysate Enhanced Ligament DifferentiationS. Chase, Mayo Clinic, Rochester, MNE. R. Wagner, Mayo Clinic, Rochester, MinnesotaS. Chase, Mayo Clinic, Rochester, MinnesotaD. Bravo, Mayo Clinic, Rochester, MinnesotaM. Dadsetan, Mayo Clinic, Rochester, MinnesotaS. Kakar, Mayo Clinic, Rochester, MinnesotaM. Yaszemski, Mayo Clinic, Rochester, Minnesota

Benchtop Tissue Surrogates to Model Drug Uptake and Efficacy

Quantification of Ultrasound-Mediated Drug Delivery using an In Vitro Flow ChamberJ. L. Chen, University of Virginia, Charlottesville, VAA. J. Dixon, University of Virginia, Charlottesville, VirginiaA. H. Dhanaliwala, University of Virginia, Charlottesville, VirginiaJ. A. Hossack, University of Virginia, Charlottesville, Virginia

Engineering a Three-Dimensional In Vitro Model of Bone Sarcoma for Drug-TestingL. Fong, Rice University, Houston, TXS. Lamhamedi Cherradi, The University of Texas MD Anderson Cancer Center, Houston, TexasE. Burdett, Rice University, Houston, TexasV. Ramamoorthy, The University of Texas MD Anderson Cancer Center, Houston, TexasA. Lazar, The University of Texas MD Anderson Cancer Center, Houston, TexasK. Kasper, Rice University, Houston, TexasM. Farach-Carson, Rice University, Houston, TexasD. Vishwamitra, The University of Texas MD Anderson Cancer Center, Houston, TexasE. Demicco, Mount Sinai Medical Center, New York, New YorkB. Menegaz, The University of Texas MD Anderson Cancer Center, Houston, TexasH. Amin, The University of Texas MD Anderson Cancer Center, Houston, TexasJ. Ludwig, The University of Texas MD Anderson Cancer Center, Houston, TexasA. Mikos, Rice University, Houston, Texas

Electrospun Nanofiber-supported Collagen Films: in vitro Modeling of Epithelial andEndothelial TissuesC. M. Neville, Massachusetts General Hospital, Boston, MAK. M. Kulig, Massachusetts General Hospital, Boston, MassachusettsS. Lauterbach, Ludwig-Maximilians-University, Munich, GermanyJ. P. Vacanti, Massachusetts General Hospital, Boston, MassachusettsC. R. Wittmer, Massachusetts General Hospital, Boston, MassachusettsC. J. Neville, Stony Brook University, Stony Brook, New York

Decellularized Skeletal Muscle Extracellular Matrix as an in vitro Model for IntramuscularDrug DevelopmentJ. J. Wang, University of California, San Diego, La Jolla, CA

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K. L. Christman, University of California, San Diego, La Jolla, CaliforniaG. R. Boss, University of California, San Diego, La Jolla, California

Biomaterial Microenvironment for Stem Cell-Based Cartilage and Intervertebral DiscRegeneration

Tunable Electrospun Hyaluronic Acid Scaffolds to Mimic the Microenvironment of ArticularCartilageI. L. Kim, University of Pennsylvania, Philadelphia, PAS. Khetan, University of Pennsylvania, Philadelphia, PennsylvaniaB. M. Baker, University of Pennsylvania, Philadelphia, PennsylvaniaC. S. Chen, University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Striking The Balance Between Optimal Cell Response And Enhanced Tissue Repair In A 3DMulti-Layered Scaffold For Cartilage RepairV. Barron, National University of Ireland, Galway, Galway, IrelandM. Neary, National University of Ireland, Galway, Galway, IrelandG. O'Malley, National University of Ireland, Galway, Galway, IrelandN. Rooney, Proxy Biomedical, Galway, IrelandF. Barry, National University of Ireland, Galway, Galway, IrelandM. Murphy, National University of Ireland, Galway, Galway, Ireland

Covalently Tethered Transforming Growth Factor Beta-1 in PEG Hydrogels ExpeditesCartilage ECM Production of Encapsulated Primary Chondrocytes.B. V. Sridhar, University of Colorado, Denver, CO

Visible light inducible chitosan composite hydrogel containing collagen or chondroitinsulfate for cartilage tissue engineeringB. Choi, University of California, Los Angeles, Los Angeles, CA

Developing the Next Generation of Cardiovascular Devices - From Concept toImplantation (An Industry Perspective)

A Nanofibrous Self-Sealing Bioactive Hemodialysis Access GraftS. G. Pathan, BioSurfaces Inc., Ashland, MAD. W. Nelson, BioSurfaces Inc., Ashland, MassachusettsS. M. Ali, BioSurfaces Inc., Ashland, MassachusettsM. J. Bide, University of Rhode Island, Kingston, Rhode IslandL. M. Fitzgerald, BioSurfaces Inc., Ashland, MassachusettsJ. R. Araya, BioSurfaces Inc., Ashland, MassachusettsT. E. Phaneuf, BioSurfaces Inc., Ashland, MassachusettsM. A. Contreras, Beth Israel Deaconess Medical Center, Boston, MassachusettsT. Phaneuf, BioSurfaces Inc., Ashland, MassachusettsM. D. Phaneuf, BioSurfaces Inc., Ashland, Massachusetts

Novel polymer based Trans Catheter Aortic Valve Implant (TAVI)A. Perera, Direct Flow Medical, santa rosa, CA

Bioabsorbable Stents Made by Rapid Fabrication SystemG. Shi, 3D Biotek, LLC, North Brunswick, NJ

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Synthesis and Analysis of Electrospun Suture for Localized Infection PreventionD. W. Nelson, BioSurfaces, Inc., Ashland, MAS. G. Pathan, BioSurfaces, Inc., Ashland, MassachusettsM. J. Bide, University of Rhode Island, Kingston, Rhode IslandC. B. Meeks, BioSurfaces, Inc., Tufts University, Ashland, MassachusettsM. A. Contreras, Beth Israel Deaconess Medical Center, Boston, MassachusettsT. M. Phaneuf, BioSurfaces, Inc., Ashland, MassachusettsM. D. Phaneuf, BioSurfaces, Inc., Ashland, Massachusetts

The Development of In Vitro Abrasion Test Method for Textile and Metal Components ofEndovascular Stent GraftsT. Yao, North Carolina State University, Raleigh, NC

Effects of Coating Methods and Solvents on the Deposition of Paclitaxel on Self-AssembledMonolayers Coated StentsS. Lamichhane, The University of South Dakota, Sioux Falls, SDA. Gallo, The University of South Dakota, Sioux Falls, South DakotaG. Mani, The University of South Dakota, Sioux Falls, South Dakota

Translational Research in Nano-biomaterials

Combined Optical and Magnetic Resonance Imaging Enables Noninvasive Trafficking ofTissue RegenerationH. Choi, Harvard Medical School, Boston, MA

Clinically Translated, Thermoplastic Biomaterial as Absorbable Scaffold for FunctionalRegeneration of Vascular, Dermal and Other Tissues: Biocoacervation of PurifiedExtracellular Matrix (ECM) Protein and GlycosaminoglycanD. B. Masters, Gel-Del Technologies, Inc, St. Paul, MNL. K. Hansen, WuXi AppTec, St. Paul, MinnesotaR. A. Meyer, Gel-Del Technologies, Inc., St. Paul, Minnesota

Biocompatibility Evaluation of Poly(N-isopropylacrylamide)-based Hydrogels forCraniofacial Bone RegenerationT. N. Vo, Rice University, Houston, TXA. K. Ekenseair, Rice University, Houston, TexasP. Spicer, Rice University, Houston, TexasB. M. Watson, Rice University, Houston, TexasF. Kasper, Rice University, Houston, TexasA. G. Mikos, Rice University, Houston, Texas

Transdermal Gelation of Hyaluronic acid Hydrogels with Gold Nanorods and Near-InfraredLightW. M. Gramlich, University of Pennsylvania, Philadelphia, PAJ. L. Holloway, University of Pennsylvania, Philadelphia, PennsylvaniaR. Rai, University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

A Gold Nanoparticle-Based System to Monitor Mesenchymal Stem Cells Delivered via aPEGylated Fibrin Matrix for Ischemic RepairL. M. Ricles, The University of Texas at Austin, Austin, TX

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S. Nam, The University of Texas at Austin, Austin, TexasS. Y. Emelianov, The University of Texas at Austin, Austin, TexasL. J. Suggs, The University of Texas at Austin, Austin, Texas

Prevention of Peritendinous Adhesions with Electrospun Poly(caprolactone)-graft-chitosanNanofibrous MatsS. Chen, Department of Chemical and Materials Engineering Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan 333, ROC, Tao-Yuan, TaiwanC. Chen, Department of Chemical and Materials Engineering Chang Gung University, Kwei-Shan,Tao-Yuan, Taiwan 333, ROC., Tao-Yuan, TaiwanJ. Chen, Department of Chemical and Materials Engineering Chang Gung University, Kwei-Shan,Tao-Yuan, Taiwan 333, ROC, Tao-Yuan, Taiwan

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Animal Models for Biomaterial and Medical Device Testing

Animal Model of Open Femur-Fracture Infection Using Noninvasive In VivoBioluminescence ImagingB. Li, West Virginia University School of Medicine, Morgantown, WVP. Farjo, West Virginia University, Morgantown, West VirginiaT. Hamza, West Virginia University, Morgantown, West Virginia

Tissue Response to Hydrogel Scaffolds Delivering Bone Morphogenetic Protein-2 for BoneAugmentationL. A. Kinard, Rice University, Houston, TXR. L. Dahlin, Rice University, Houston, TexasA. M. Henslee, Rice University, Houston, TexasP. P. Spicer, Rice University, Houston, TexasC. Chu, Rice University, Houston, TexasF. K. Kasper, Rice University, Houston, TexasA. G. Mikos, Rice University, Houston, Texas

Projection Micro-StereoLithography (PmSL) Printed PDMS Substrates to Study FlapRevascularization in an Ischemic Mouse ModelK. N. Cicotte, University of New Mexico, Albuquerque, NMP. G. McGuire, Department of Cell Biology and Physiology, Albuquerque, New MexicoT. R. Howdieshell, University of New Mexico Health Science Center, Albuquerque, New MexicoE. L. Hedberg-Dirk, University of New Mexico, Albuquerque, New Mexico

Post-Surgical Pain Management using Long Lasting Analgesic Release from Sol Gel PowderT. Briggs, University of Pennsylvania, Philadelphia, PAP. Ducheyne, University of Pennsylvania, Philadelphia, PennsylvaniaJ. Garino, Orthopedic Surgery Lankenau Institute for Medical Research, Malvern, Pennsylvania

Staphylococcus epidermidis Vaccines against Biomaterial Associated InfectionsL. Yan, University of Washington, Seattle, WA

Towards Understanding the Skin-Percutaneous Implant Integration with the Host SoftTissue

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D. H. Betz, University of Utah, Salt Lake City, UTT. A. Ford, University of Utah, Salt Lake City, UtahB. M. Holt, University of Utah, Salt Lake City, UtahM. Van Dyke, Virginia Polytechnic Institute and State University, Blacksburg, VirginiaJ. P. Beck, University of Utah, Salt Lake City, UtahR. D. Bloebaum, University of utah, Salt Lake City, UtahS. Jeyapalina, University of Utah, Salt Lake City, Utah

Evaluation of an Absorbable Gentamicin Eluting Plate Sleeve in an Ovine Fracture ModelC. DePaula, DePuy Synthes - Biomaterials, West Chester, PA

Animal Models for Biomaterials Screening and Neo-Kidney Augment Prototype Evaluation inthe KidneyR. Payne, Tengion, Inc., Winston-Salem, NCT. Knight, Tengion, Inc., Winston-Salem, North CarolinaJ. Basu, Tengion, Inc., Winston-Salem, North CarolinaE. Rivera, Tengion, Inc, Winston-Salem, North CarolinaK. Mihalko, Carolinas Medical Center, Charlotte, North CarolinaN. Robbins, Tengion Inc., Winston-Salem, North CarolinaD. McCoy, Tengion Inc., Winston-Salem, North CarolinaC. Halberstadt, Tengion, Inc, Winston-Salem, North CarolinaD. Jain, Tengion Inc., Winston-Salem, North Carolina

Biomaterials Design and Tissue Engineering via Synthetic Biology

Bacterial Virulence Proteins as Tools to Rewire Kinase Pathways in Immune CellsW. W. Wong, Boston University, Boston, MA

Development of Synthetic Platelets for Hemostatic ApplicationsA. C. Brown, Georgia Institute of Technology, Atlanta, GAS. Stabenfeldt, Arizona State University, Tempe, ArizonaB. Ahn, Georgia Institute of Technology and Children’s Healthcare of Atlanta / Emory UniversitySchool of Medicine, Atlanta, GeorgiaR. Hannan, Georgia Institute of Technology, Atlanta, GeorgiaK. Dhada, Georgia Institute of Technology, Atlanta, GeorgiaW. Lam, Georgia Institute of Technology and Children’s Healthcare of Atlanta / Emory UniversitySchool of Medicine, Atlanta, GeorgiaA. Lyon, Georgia Institute of Technology, Atlanta, GeorgiaT. Barker, Georgia Institute of Technology and Emory University, Atlanta, Georgia

Synthetic Biology-inspired Biohybrid Materials for Tissue Engineering and Inducible DrugDeliveryW. Weber, University of Freiburg, Freiburg, Germany

Characterization of Modular Resilin-based Biomaterials with Tunable Mechanical Propertiesfor Cartilage EngineeringJ. C. Liu, Purdue University, West Lafayette, INJ. C. Liu, Purdue University, West Lafayette, IndianaR. Su, Purdue University, West lafayette, Indiana

Synthesis of thermo-responsive, protein reactive copolymer for cartilage tissue engineeringA. Fathi, Jr., The University of Sydney, Sydney, Australia

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Development of a novel microfabricated cell-laden bioelastomerN. Annabi, Harvard Medical School, Cambridge, MAM. Afshar, Harvard medical School, Cambridge, MassachusettsK. Tsang, Harvard Medical School, Cambridge, MassachusettsS. Mithieux, University of Sydney, Sydney, AustraliaM. Nikkhah, Harvard Medical School, Cambridge, MassachusettsA. S. Weiss, University of Sydney, Sydney, AustraliaA. Khademhosseini, Harvard Medical School, Cambridge, Massachusetts

Dental / Craniofacial Materials

Design and Optimization of a Cell-Instructive Hydrogel for Dental Pulp Tissue EngineeringS. Prateepchinda, Columbia University, New York, NYH. H. Lu, Columbia University, New York, New YorkG. B. Hasselgren, Columbia University, New York, New YorkD. Seliktar, Technion – Israel Institute of Technology, Haifa, Israel

Bone Regeneration using Bone Morphogenetic Protein-2 Loaded Tyrosine PolycarbonateScaffoldsT. Guda, University of Texas at San Antonio, San Antonio, TXP. Brown-Baer, United States Army Institute of Surgical Research, Fort Sam Houston, TexasT. Silliman, United States Army Institute of Surgical Research, Fort Sam Houston, TexasA. Darr, Rutgers, The State University of New Jersey, Piscataway, New JerseyJ. Kohn, Rutgers, The State University of New Jersey, Piscataway, New Jersey

In Vitro Evaluation of Inkjet 3D-Printed (3DP) Fe-Mn Biodegradable Metallic ScaffoldsD. Chou, University of Pittsburgh, Pittsburgh, PAD. Hong, University of Pittsburgh, Pittsburgh, PennsylvaniaH. A. Kuhn, University of Pittsburgh, Pittsburgh, PennsylvaniaP. N. Kumta, University of Pittsburgh, Pittsburgh, Pennsylvania

Effect of Nanofiber Alignment on Human Periodontal Ligament Fibroblast ResponseN. M. Lee, Columbia University, New York, NYS. Kuznetsov, Columbia University Dental School, New York, New YorkS. Eisig, Columbia University Dental School, NY, New YorkH. H. Lu, Columbia University, New York, New York

A novel air-based non-thermal plasma (NTP) approach for the enhancement of Ti-6Al-4Vdental implantsL. Witek, Oklahoma State University, Stillwater, OKN. Tovar, New York University, New York, New YorkC. Marin, UNIGRANRIO University-School of Health Sciences, Rio de Janeiro, BrazilE. A. Bonafante, UNIGRANRIO University-School of Health Sciences, Rio de Janeiro, BrazilR. Granato, UNIGRANRIO University-School of Health Sciences, Rio de Janeiro, BrazilM. Suzuki, Tufts University School of Dental Medicine, Boston, MassachusettsP. G. Coelho, New York University, New York, New York

Structure/Property of Model Dentin Adhesive Exposed to Wet EnvironmentsP. Spencer, University of Kansa, Lawrence, KSQ. Ye, University of Kansas, Lawrence, KansasR. Parthasarathy, University of Kansas, Lawrence, Kansas

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V. Singh, University of Kansas, Lawrence, KansasA. Misra, University of Kansas, Lawrence, KansasJ. S. Laurence, University of Kansas, Lawrence, Kansas

Photo-polymerization Kinetics of Hydrophilic-rich Phase Mimic in Dentin AdhesiveQ. Ye, University of Kansas, Lawrence, KSF. Abedin, University of Kansas, Lawrence, KansasP. Spencer, University of Kansas, Lawrence, KansasR. Parthasarathy, University of Kansas, Lawrence, KansasA. Misra, University of Kansas, Lawrence, KansasJ. S. Laurence, University of Kansas, Lawrence, Kansas

Combination Use of Autologous Periodontal Ligament-derived Cell Sheets and Beta-tricalcium Phosphate Granules in Periodontal Defects in HumansT. Iwata, Tokyo Women’s Medical University, Tokyo, Japan

Orthopaedic Biomaterials2

Non-Degradable Porous Poly(Vinyl Alcohol) Hydrogels for Cartilage Tissue EngineeringH. Bodugoz-Senturk, Massachusetts General Hospital, Boston, MAD. Bichara, Massachusetts General Hospital, Boston, MassachusettsD. Ling, Massachusetts General Hospital, Boston, MassachusettsC. Gupta, Massachusetts General Hospital, Boston, MassachusettsM. Randolph, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

The Influence of Cathodic Polarization and Simulated Inflammation on Titanium AlloyElectrochemistryE. K. Brooks, University at Buffalo, Buffalo, NYM. Ehrensberger, University at Buffalo, Buffalo, New YorkM. Tobias, University at Buffalo, Buffalo, New York

Development of biodegradable ZK40, WX11, and WX41: Novel Mg based alloys fororthopedic applicationsD. Hong, University of Pittsburgh, Pittsburgh, PAD. Chou, University of Pittsburgh, Pittsburgh, PennsylvaniaP. Saha, University of Pittsburgh, Pittsburgh, PennsylvaniaO. Velikokhatnyi, University of Pittsburgh, Pittsburgh, PennsylvaniaP. N. Kumta, University of Pittsburgh, Pittsburgh, Pennsylvania

The Effect of Micro-textured CoCrMo-carbide Surfaces on the Attachment and Viability ofOsteoblast-like MG63S. J. L. Sullivan, University of Maryland, Baltimore County, Baltimore, MDA. Au, Nutramax Laboratories, Inc., Edgewood, MarylandM. Grzanna, Nutramax Laboratories, Inc., Edgewood, MarylandT. Pham, University of Maryland, Baltimore County, Baltimore, MarylandC. Frondoza, Nutramax Laboratories, Inc., Edgewood, MarylandL. Topoleski, University of Maryland, Baltimore County, Baltimore, Maryland

The Effect of Processing Time, Temperature, and Methane Concentration on Micro-textured Ti6Al4V-carbide Surface Roughness ParametersS. J. L. Sullivan, University of Maryland, Baltimore County, Baltimore, MD

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L. Topoleski, University of Maryland, Baltimore County, Baltimore, Maryland

Reduced UHMWPE Wear Using Magnesia-Stabilized Zirconia Femoral Components in HighKinematics/High Load Knee Simulator TestsM. E. Roy, Missouri Bone & Joint Research Foundation, St. Louis, MOL. A. Whiteside, Missouri Bone & Joint Research Foundation; Signal Medical Corp., St. Louis, MO, St.Louis, MissouriO. F. Noel, IV, Missouri Bone & Joint Research Foundation; Rocky Vista University College ofOsteopathic Medicine, Parker, CO, St. Louis, Missouri

Vitamin E-Stabilized, Highly Cross-linked UHMWPE Implants: A Short-Term Retrieval StudyS. Rowell, Massachusetts General Hospital, Boston, MAK. Wannomae, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Confined and Unconfined Creep: A Comparative Study of Swine Cartilage and PVAHydrogelsD. Ling, Massachusetts General Hospital, Boston, MAH. Bodugoz-Senturk, Massachusetts General Hospital, Boston, MassachusettsC. Serrano, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Stem Cell-Biomaterial Interactions

A Comparative Study of the 2D versus 3D Presentation of Matrix Stiffness on Stem Cell FateM. Guvendiren, University of Pennsylvania, Philadelphia, PAK. Sudhir, University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Surface Properties Modulate Integrins, Pluripotent Markers, and Morphogens in Embryonicand Adult Stem CellsR. Olivares-Navarrete, Georgia Institute of Technology, Atlanta, GAC. A. Cundiff, Georgia Institute of Technology, Atlanta, GeorgiaS. L. Hyzy, Georgia Institute of Technology, Atlanta, GeorgiaM. T. Cook, Georgia Institute of Technology, Atlanta, GeorgiaS. L. Stice, University of Georgia, Athens, GeorgiaZ. Schwartz, Georgia Institute of Technology, Atlanta, GeorgiaT. McDevitt, Georgia Institute of Technology, Atlanta, GeorgiaB. D. Boyan, Georgia Institute of Technology, Atlanta, Georgia

Effect of Nanofiber Mineral Content on Human Mesenchymal Stem Cell OsteogenesisS. D. Subramony, Columbia University, New York, NYD. Qu, Columbia University, New York, New YorkA. Su, Columbia University, New York, New YorkJ. P. Heisler, Columbia University, New York, New YorkH. H. Lu, Columbia University, New York, New York

Comparative Evaluation of Hydrogels As a 3D Angiogenic Matrix for Adipose-Derived StemCellsE. Chung, The University of Texas at Austin, Austin, TXJ. A. Rytlewski, The University of Texas at Austin, Austin, TexasA. G. Merchant, The University of Texas at Austin, Austin, Texas

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E. W. Lewis, The University of Texas at Austin, Austin, TexasL. J. Suggs, The University of Texas at Austin, Austin, Texas

Direct reprograming of mouse fibroblasts to cardiomyocytes using Yamanaka factors onengineered hydrogelsD. L. Elbert, Washington University in St. Louis, St. Louis, MOA. Smith, Washington University in St. Louis, St. Louis, MissouriP. K. Nguyen, Washington University in St. Louis, St. Louis, MissouriI. Efimov, Washington University in St. Louis, St. Louis, Missouri

Protein-based Biomaterials Accelerate Osteogenic DifferentiationY. Kim, Purdue University, West Lafayette, INJ. Liu, Purdue University, West Lafayette, Indiana

Surface Modification Strategies for Antimicrobial Medical Devices

A Surface Modification Platform on Eluting Medical DevicesC. Loose, Semprus BioSciences, Cambridge, MAH. Wang, Semprus BioSciences, Cambridge, MassachusettsR. Smith, Semprus BioSciences, Cambridge, MassachusettsG. Brotske, Semprus BioSciences, Cambridge, MassachusettsA. Cook, Semprus BioSciences, Cambridge, MassachusettsZ. Zhang, Semprus BioSciences, Cambridge, Massachusetts

Local Delivery of D-Amino Acids Reduces Bacterial Burden in Contaminated Rat SegmentalDefectsE. M. Prieto, Vanderbilt University, Nashville, TNC. J. Sanchez, Jr., United States Army Institute of Surgical Research, Fort Sam Houston, TexasC. A. Kruger, United States Army Institute of Surgical Research, Fort Sam Houston, TexasK. J. Zienkiewicz, Vanderbilt University, Nashville, TennesseeD. R. Romano, United States Army Institute of Surgical Research, Fort Sam Houston, TexasK. S. Askers, United States Army Institute of Surgical Research, Fort Sam Houston, TexasS. K. Hardy, United States Army Institute of Surgical Research, Fort Sam Houston, TexasR. L. Woodburry, United States Army Institute of Surgical Research, Fort Sam Houston, TexasS. A. Guelcher, Vanderbilt University, Nashville, TennesseeJ. C. Wenke, United States Army Institute of Surgical Research, Fort Sam Houston, Texas

Proximity and Cell Density Effects on the Killing Ability of Mg and MgTi Microparticles In-VitroJ. Kim, Syracuse University, Syracuse, NYJ. L. Gilbert, Syracuse University, Syracuse, New York

Sol-gel silica controlled release thin film for inhibition of methicillin resistantstaphylococcus aureusS. Bhattacharyya, University of Pennsylvania, Philadelphia, PA

Nano-BaSO4 as a Novel Agent to Yield Antimicrobial Thermoplastics for Medical TubingG. E. Aninwene, II, Northeastern University, East Providence, RID. Stout, Brown University, Providence, Rhode IslandZ. Yan, Brown University, Providence, Rhode IslandT. J. Webster, Northeastern University, Boston, MassachusettsB. C. LaBrec, Foster Biomedical Polymers and Compounds, Putnam, Connecticut

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Silicone Based Nanocomposite for Treatment of HydrocephalusD. MISRA, UNIVERSITY OF LOUISIANA AT LAFAYETTE, LAFAYETTE, LAFAYETTE, NY

Long-term stability and effectiveness of antimicrobial coatings incorporating PSP-derivedpeptidesX. Chen, University of Minnesota, Minneapolis, MNH. Hirt, University of Minnesota, Minneapolis, MinnesotaK. V. Holmberg, University of Minnesota, Minneapolis, MinnesotaS. Gorr, University of Minnesota, Minneapolis, MinnesotaC. Aparicio, University of Minnesota, Minneapolis, Minnesota

PCL (Col)/PVA (HA) coaxial electrospun nanofibers for controllable and sustained drugreleaseW. Song, Wayne state university, Detroit, MI

CS6

Bioinspired Smart Materials for Regenerative Medicine Applications

Novel conduits for Schwann Cell Induced Spinal Cord RepairY. Lee, University of Miami, Miami, FLS. Wu, New Jersey Institute of Technology, Newark, New JerseyI. Sidhu, New Jersey Institute of Technology, Newark, New JerseyT. Livingston Arinzeh, New Jersey Institute of Technology, Newark, New JerseyM. B. Bunge, University of Miami, Miami, Florida

Superporous Extracellular Matrix Mimics for On-demand Release of Growth Factors Basedon Nucleic Acid Aptamers and Superporous HydrogelsM. R. Battig, University of Connecticut, Storrs, CTN. Chen, University of Connecticut, Storrs, ConnecticutY. Wang, University of Connecticut, Storrs, Connecticut

Thrombin-responsive hydrogels with varied cleavage kineticsC. Sperling, Leibniz-Institute of Polymer Research Dresden, Dresden, GermanyM. Rentsch, Leibniz-Institute of Polymer Research Dresden / Hochschule Zittau/Görlitz, Dresden,GermanyM. Tsurkan, Leibniz-Institute of Polymer Research Dresden, Dresden, GermanyU. Freudenberg, Leibniz-Institute of Polymer Research Dresden, Dresden, GermanyM. F. Maitz, Leibniz-Institute of Polymer Research Dresden, Dresden, GermanyC. Werner, Leibniz-Institute of Polymer Research Dresden, Dresden, Germany

Thermo-responsive citrate-based nanonets for tissue regeneration: effects of localizedSDF-1 releaseJ. Yang, Northwestern University, Evanston, ILJ. Yang, Northwestern University, Evanston, IllinoisR. Hoshi, Northwestern University, Evanston, IllinoisK. Baler, Northwestern University, Evanston, IllinoisG. Ameer, Northwestern University, Evanston, Illinois

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Novel Biomimetic Proteoglycans for Molecular Engineering of Degenerated TissueK. Prudnikova, Drexel University, Philadelphia, PAS. Lightfoot Vidal, Drexel University, Philadelphia, PennsylvaniaE. Vresilovic, Pennsylvania State College of Medicine, Hershey, PennsylvaniaM. Marcolongo, Drexel University, Philadelphia, Pennsylvania

Protease Triggered Release of Macromolecules from MMP-sensitive Hyaluronic AcidHydrogelsB. P. Purcell, University of Pennsylvania, Philadelphia, PAM. Charati, University of Pennsylvania, Philadelphia, PennsylvaniaR. Wade, University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Heparin functionalized thermoresponsive cell culture surfaces for regulating affinityinteraction with basic fibroblast growth factor and enhancing cell sheet formationJ. Kobayashi, Tokyo Women's Medical University, Tokyo, Japan

Biomimetic Calcium Carbonate Concentric Microgrooves for Promoting MC3T3-E1 CellFunctionsS. Wang, The University of Tennessee, Knoxville, TNX. Wu, The University of Tennessee, Knoxville, Tennessee

Biologically Derived Materials From Natural Resources

Cartilage Matrix Gels Promote Chondrogenesis of Human Mesenchymal Stem CellsO. A. Burnsed, Georgia Institute of Technology, Atlanta, GAR. Olivares-Navarrete, Georgia Institute of Technology, Atlanta, GeorgiaS. L. Hyzy, Georgia Institute of Technology, Atlanta, GeorgiaK. O. Marchand, Georgia Institute of Technology, Atlanta, GeorgiaB. D. Boyan, Georgia Institute of Technology, Atlanta, GeorgiaZ. Schwartz, Georgia Institute of Technology, Atlanta, Georgia

Engineering Vascularized Skin Flap with Decellularized Skin Flap Matrix ScaffoldL. Wang, UT MD Anderson Cancer Center, Houston, TXQ. Zhang, UT MD Anderson Cancer Center, Houston, TexasJ. A. Johnson, UT MD Anderson Cancer Center, Houston, TexasD. W. Chang, UT MD Anderson Cancer Center, Houston, Texas

Bioskiving: Bioinspired Fabrication of Nanostructures from Tissue SlicesQ. Xu, Tufts University, Medford, MA

Production of Recombinant Bacterial Collagens for Use as New Materials for BiomedicalApplicationsJ. A. M. Ramshaw, CSIRO - Materials Science and Engineering, Clayton, AustraliaY. Y. Peng, CSIRO - Materials Science and Engineering, Clayton, AustraliaV. Stoichevska, CSIRO - Materials Science and Engineering, Clayton, AustraliaL. Howell, CSIRO - Materials Science and Engineering, Clayton, AustraliaS. Madsen, CSIRO - Materials Science and Engineering, Clayton, AustraliaG. Dumsday, CSIRO - Materials Science and Engineering, Clayton, AustraliaJ. Werkmeister, CSIRO - Materials Science and Engineering, Clayton, Australia

In vivo potential of functionally graded platelet lysates scaffolds for osteochondral repair

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V. E. Santo, University of Minho - 3B's Research Group, Caldas das Taipas, PortugalA. R.C. Duarte, University of Minho - 3B's Research Group, Caldas das Taipas, PortugalP. P. Carvalho, University of Minho, 3B's Research Group, Caldas das Taipas, PortugalJ. F. Requicha, University of Minho, 3B's Research Group, Caldas das Taipas, PortugalC. A.A. Viegas, University of Trás-os-Montes e Alto Douro, Department of Veterinary Sciences, VilaReal, PortugalI. R. Dias, University of Trás-os-Montes e Alto Douro, Department of Veterinary Sciences, Vila Real,PortugalJ. F. Mano, University of Minho, 3B's Research Group, Caldas das Taipas, PortugalM. E. Gomes, University of Minho, 3B's Research Group, Caldas das Taipas, PortugalR. L. Reis, University of Minho, 3B's Research Group, Caldas das Taipas, Portugal

Hyaluronic acid Hydrogels Synthesized by Thiol-ene Step Growth PolymerizationW. M. Gramlich, University of Pennsylvania, Philadelphia, PAJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Biomaterial Strategies for Innervation, Nerve Repair and Integration

Chronic Blood Brain Barrier Breach Contributes to Intracortical Electrode Recording FailureT. Saxena, Georgia Institute of Technology, Atlanta, GAL. Karumbaiah, Georgia Institute of Technology, atlanta, GeorgiaE. Gaupp, Georgia Institute of Technology, Atlanta, GeorgiaK. Patil, garrett.stanley@bme.gatech.edu, Atlanta, GeorgiaR. Patkar, Georgia Institute of Technology, atlanta, GeorgiaM. Betancur, Georgia Institute of Technology, Atlanta, GeorgiaG. Stanley, Georgia Institute of Technology, Atlanta, GeorgiaR. Bellamkonda, Georgia Institute of Technology, Atlanta, Georgia

Mechanical Evaluation of an Ultrafast Degrading Polymer as a Temporary Coating for NeuralProbesJ. Kohn, Rutgers - The State University of New Jersey, Piscataway, NJS. Wang, Rutgers - The State University of New Jersey, Piscataway, New JerseyJ. Lo, Rutgers - The State University of New Jersey, Piscataway, New JerseyS. Singh, Rutgers - The State University of New Jersey, Piscataway, New JerseyJ. Zahn, Rutgers - The State University of New Jersey, Piscataway, New JerseyD. Shreiber, Rutgers - The State University of New Jersey, Piscataway, New Jersey

Biomaterials and Electrode Strategies in Regenerative Peripheral Nerve InterfacesN. B. Langhals, University of Michigan, Ann Arbor, MIJ. V. Larson, University of Michigan, Ann Arbor, MichiganT. A. Kung, University of Michigan, Ann Arbor, MichiganK. B. Sugg, University of Michigan, Ann Arbor, MichiganJ. D. Moon, University of Michigan, Ann Arbor, MichiganP. S. Cederna, University of Michigan, Ann Arbor, MichiganM. G. Urbanchek, University of Michigan, Ann Arbor, Michigan

Flexible and Kink-Resistant Braided Conduits for Peripheral Nerve RegenerationB. A. Clements, Rutgers - The State University of New Jersey, Piscataway, NJJ. Bushman, Rutgers - The State University of New Jersey, Piscataway, New JerseyS. Murthy, Rutgers - The State University of New Jersey, Piscataway, New JerseyJ. Kohn, Rutgers - The State University of New Jersey, Piscataway, New Jersey

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Microchannel Scaffolds as Regenerative Peripheral Nerve InterfacesA. Srinivasan, Georgia Institute of Technology, Atlanta, GAA. Haque, Georgia Institute of Technology, Atlanta, GeorgiaM. Tahilramani, Georgia Institute of Technology, Atlanta, GeorgiaR. V. Bellamkonda, Georgia Institute of Technology, Atlanta, GeorgiaG. B. Stanley, Georgia Institute of Technology, Atlanta, Georgia

SDF-1α-loaded Dextran Sulfate/Chitosan Nanoparticles As a Multi-pronged Approach toEnhance Neural Stem Cell Infiltration into Hydrogels for CNS ApplicationsT. Lim, Massachusetts Institute of Technology, Cambridge, MAS. Rokkappanavar, Brigham and Women's Hospital, Harvard Medical School, Boston, MassachusettsM. Kurisawa, Institute of Bioengineering and Nanotechnology, Singapore, SingaporeM. Spector, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts

Novel Rapidly-Gelling Injectable Chitosan Sponge to Promote Oligodendrocyte ProgenitorCells’ DifferentiationM. Mekhail, McGill, Montreal, QC, CanadaG. Almazan, McGill, Montreal, Québec, CanadaM. Tabrizian, McGill, Montreal, Québec, Canada

Enhancement of Astrocyte Migration Through Collagen-Genipin Gels in Response toFibroblast Growth Factor-2D. Macaya, Massachusetts Institute of Technology, brookline, MAK. Hayakawa, Massachusetts General Hospital, Charlestown, MassachusettsK. Arai, Massachusetts General Hospital, charlestown, MassachusettsM. Spector, VA Medical Center Boston, Massachusetts Institute of Technology, Jamaica Plain,Massachusetts

Drug Delivery for Inflammatory Diseases

Control of Mesenchymal Stem Cell Phenotype and Microenvironment through IntracellularParticlesJ. A. Ankrum, MIT, Cambridge, MAO. Faii, MIT, Cambridge, MassachusettsO. Levy, MIT, Cambridge, MassachusettsJ. Karp, MIT, Cambridge, Massachusetts

Dual stimuli-responsive antioxidant nanoparticles based on polymeric prodrugs of vanillinJ. Kim, Department of BIN Fusion Tech. Chonbuk National University, Jeonju-si, Republic ofKorea

Enhanced Intracellular Peptide Delivery with pH-responsive, Endosomolytic Nano-Polyplexes to Prevent Intimal Hyperplasia in Human Saphenous Vein GraftsB. C. Evans, Vanderbilt University, Nashville, TNK. M. Hocking, Vanderbilt University, Nashville, TennesseeC. M. Brophy, Vanderbilt Heart and Vascular Institute, Nashville, TennesseeC. L. Duvall, Vanderbilt University, Nashville, Tennessee

Amphiphilic Nanoparticles as Molecular Therapeutics for AtherosclerosisL. Petersen, Rutgers University, Piscataway, NJA. York, Rutgers Unviersity, Piscataway, New JerseyS. Ahuja, Rutgers University, Piscataway, New Jersey

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S. Gadamsetty, Rutgers University, Piscataway, New JerseyK. Uhrich, Rutgers University, Piscataway, New JerseyR. Prud’homme, Princeton University, Princeton, New JerseyP. Moghe, Rutgers University, Piscataway, New Jersey

Biocompatible polymeric nanoparticles degrade and release cargo in response tobiologically relevant levels of hydrogen peroxideA. Almutairi, University of California, San Diego, La Jolla, CAC. de Gracia Lux, University of California, San Diego, La Jolla, CaliforniaS. Joshi-Barr, University of California, San Diego, La Jolla, CaliforniaT. Nguyen, University of California, San Diego, La Jolla, CaliforniaE. Mahmoud, University of California, San Diego, La Jolla, CaliforniaN. Fomina, University of California, San Diego, La Jolla, California

Antioxidant nanoparticles for inhibition of inflammation-mediated rheumatoid arthritisD. Cochran, University of Kentucky, Lexington, KY

Development of a Poly(lactic acid) Poly(ethylene glycol) Nanoparticle for Delivery ofVitamin D3 for Severe AsthmaticsN. K. Comolli, Villanova University, Villanova, PAR. Lojek, Villanova University, Villanova, PennsylvaniaA. Banerjee, University of Pennsylvania, Philadelphia, PennsylvaniaR. Panettieri, Jr., University of Pennsylvania, Philadelphia, Pennsylvania

Antigen-Specific Immune Response of Microparticle Vaccine Containing CpG-ODN andProteinQ. Wang, Baylor College of Medicine, Houston, TXM. A. Barry, Baylor College of Medicine, Houston, TexasM. Knight, Southwest Electronic Medical Research Institute, Houston, TexasC. M. Beaumier, Baylor College of Medicine, Houston, TexasM. J. Heffernan, Baylor College of Medicine, Houston, Texas

Role of Biological Factors in Osteoconduction and Bone Engineering

Electrospun Osteoconductive and Osteoinductive Bicomponent Scaffolds: ControlledRelease of rhBMP-2 and Enhanced Biological Performance of ScaffoldsC. Wang, The University of Hong Kong, Hong Kong SAR, Hong KongM. Wang, The University of Hong Kong, Hong Kong SAR, Hong Kong

Bone Morphogenetic Protein 2 Induces an Inflammatory Profile in MSCs on MicrostructuredTitaniumS. L. Hyzy, Georgia Institute of Technology, Atlanta, GAR. Olivares-Navarrete, Georgia Institute of Technology, Atlanta, GeorgiaS. Ortman, Georgia Institute of Technology, Atlanta, GeorgiaB. D. Boyan, Georgia Institute of Technology, Atlanta, GeorgiaZ. Schwartz, Georgia Institute of Technology, Atlanta, Georgia

Polydopamine-Coated PDMS-PCL Shape Memory Polymer Foams for Bone RegenerationA. Jimenez-Vergara, Rensselaer Polytechnic Institute, Troy, NYD. J. Munoz-Pinto, Rensselaer Polytechnic Institute, Troy, New YorkD. Zhang, Texas A&M University, College Station, TexasM. Grunlan, Texas A&M University, College Station, Texas

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M. S. Hahn, Rensselaer Polytechnic Institute, Troy, New York

Sustained Bone Morphogenetic Protein 2 Delivery from Densified Titanium for the HardTissue EngineeeringH. Jung, Department of Materials Science and Engineering, Seoul National University,Seoul, Republic of KoreaT. Jang, Seoul National Univ., Seoul, Republic of KoreaM. Kang, Department of Materials Science and Engineering, Seoul National University, Seoul, Korea,Seoul, Republic of KoreaH. Park, Seoul National Univ., Seoul, Republic of KoreaH. Kim, Department of Materials Science and Engineering, Seoul National University, Seoul, Korea,Seoul, Republic of KoreaY. Estrin, Department of Materials Engineering, Monash University, Clayton, Australia, Clayton,AustraliaY. Koh, Korea Univ., Seoul, Republic of Korea

Molecule Release from Proteolytically Degradable Hyaluronic Acid Hydrogels for ImprovedOsteogenesisJ. L. Holloway, University of Pennsylvania, Philadelphia, PAB. Purcell, University of Pennsylvania, Philadelphia, PennsylvaniaS. Khetan, University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Enhanced Osteogenic Differentiation of Adipose-Derived Stem Cells in Growth FactorPresenting Gelatin HydrogelsJ. E. Samorezov, Case Western Reserve University, Cleveland, OHE. Alsberg, Case Western Reserve University, Cleveland, Ohio

Bone Regenerative Capacity of rhBMP-2 Loaded Carboxymethylchitosan Microspheres in aRat Calvarial DefectB. Reves, University of Memphis, Memphis, TNJ. A. Jennings, University of Memphis, Memphis, TennesseeP. Konofaos, University of Tennessee Health Science Center, Memphis, TennesseeD. Petersen, University of Tennessee Health Science Center, Memphis, TennesseeR. Wallace, University of Tennessee Health Science Center, Memphis, TennesseeR. Smith, University of Tennessee Health Science Center, Memphis, TennesseeT. Guda, University of Texas at San Antonio, San Antonio, TexasM. Appleford, University of Texas at San Antonio, San Antonio, TexasW. O. Haggard, University of Memphis, Memphis, TennesseeJ. D. Bumgardner, University of Memphis, Memphis, Tennessee

Controlling Secretion of VEGF from 3D Stem Cell Aggregates to Enhance OsteochondralBone RegenerationJ. O. Blanchette, University of South Carolina, Columbia, SCM. L. Skiles, University of South Carolina, Columbia, South CarolinaL. R. Rucker, University of South Carolina, Columbia, South CarolinaS. Sahai, University of South Carolina, Columbia, South Carolina

CS7

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Engineering Instructive Cues Biomaterials

Hydrogels that Mimic Developmentally Relevant N-Cadherin Interactions Enhance MSCChondrogenesisL. Bian, the Chinese University of Hong Kong, Shatin, Hong KongM. Guvendiren, the University of Pennsylvania, Philadelphia, PennsylvaniaR. Mauck, the University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, the University of Pennsylvania, Philadelphia, Pennsylvania

Multi-Compartment Collagen-Glycosaminoglycan Scaffolds for Engineering the Tendon-Bone JunctionS. R. Caliari, University of Illinois at Urbana-Champaign, Urbana, IL

Coil-tagging of Vascular Endothelial Growth Factor for Oriented and Tunable BiomaterialsFunctionalizationF. Murschel, Ecole Polytechnique de Montreal, Montreal, QC, CanadaB. Liberelle, Ecole Polytechnique de Montreal, Montreal, Québec, CanadaG. St-Laurent, Biotechnology Research Institute, Montreal, Québec, CanadaM. Jolicoeur, Ecole Polytechnique de Montreal, Montreal, Québec, CanadaY. Durocher, Biotechnology Research Institute, Montreal, Québec, CanadaR. S. Hodges, University of Colorado, School of Medicine, Aurora, ColoradoG. De Crescenzo, Ecole Polytechnique de Montreal, Montreal, Québec, Canada

Modulation of Endothelial Cell Response Through Surface Patterning of VEGFA. S. C. Soon, University of California, Los Angeles, Los Angeles, CAT. Segura, University of California, Los Angeles, Los Angeles, California

Designer growth factor gradients produced by microsphere-assembled scaffoldsD. L. Elbert, Washington University in St. Louis, St. Louis, MOJ. L. Roam, Washington University in St. Louis, St. Louis, MissouriP. K. Nguyen, Washington University in St. Louis, St. Louis, Missouri

Manipulation of Protein Sequence and Functionalization to Enhance Cell Interactions withBioactive HydrogelsM. Browning, Texas A&M University, College Station, TXB. Russell, Texas A&M Health Science Center, Houston, TexasJ. Rivera, Texas A&M Health Science Center, Houston, TexasP. T. Luong, Texas A&M University, College Station, TexasM. Hook, Texas A&M Health Science Center, Houston, TexasE. Cosgriff-Hernandez, Texas A&M University, College Station, Texas

Engineering functional microparticles to fabricate instructive cell microenvironmentsC. A. Custódio, 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics,Caldas das Taipas-Guimarães, PortugalV. E. Santo, 3B’s Research Group- Biomaterials, Biodegradables and Biomimetics, Caldas dasTaipas-Guimarães, PortugalM. M. E. Gomes, 3B's Research Group-Biomaterials, Biodegradables and Biomimetics, Caldas dasTaipas-Guimarães, PortugalR. L. Reis, 3B's Research Group- Biomaterials, Biodegradables and Biomimetics, Caldas das Taipas-Guimarães, PortugalJ. F. Mano, 3B´s Research Group-Biomaterials, Biodegradables and Biomimetics, Caldas das Taipas-Guimarães, Portugal

Biomimetic microenvironments for controlling morphogenesis of human pancreatic ductal

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epithelial cellsA. Raza, Indiana-University Purdue-University Indianapolis, Indianapolis, IN

Nanostructured Biomaterials and Porous Scaffolds

Synthetic Matrix Vesicles Modulate Mineralization Response of Human Osteoblast-like CellsP. J. Chuang, Columbia University, New York, NYT. O. Akinade, Columbia University, New York, New YorkL. C. Kam, Columbia University, New York, New YorkH. H. Lu, Columbia University, New York, New York

A bio-inspired hybrid nanosack for the delivery of pancreatic islets and FGF-2 to improveislet engraftment at the omentum siteH. Jun, University of Alabama at Birmingham, Birmingham, ALP. Hwang, University of Alabama at Birmingham, Birmingham, AlabamaD. Lim, University of Alabama at Birmingham, Birmingham,, AlabamaS. Gilbert, University of Alabama at Birmingham, Birmingham,, AlabamaW. Cui, University of Alabama at Birmingham, Birmingham, AlabamaJ. Corbett, Medical College of Wisconsin, Milwaukee, Wisconsin

Design of Short Synthetic β-sheet Forming Peptide Amphiphiles for AntimicrobialApplicationsZ. Ong, Institute of Bioengineering and Nanotechnology, Singapore, SingaporeY. Yang, Institute of Bioengineering and Nanotechnology, Singapore, Singapore

Biphasic Scaffolds for Bone Repair: Nanofiber-Permeated Pore Network for Enhanced CellPopulationC. S. Nelson, University of Connecticut Health Center, Farmington, CTY. Khan, University of Connecticut, Farmington, ConnecticutC. T. Laurencin, University Of Connecticut Health Center, Farmington, Connecticut

Polyethylene glycol-based Protein Nanocapsules for Functional Delivery of a DifferentiationTranscription FactorA. Biswas, University of California at Los Angeles, Los Angeles, CAY. Liu, University of California at Los Angeles, Los Angeles, CaliforniaG. Fan, University of California at Los Angeles, Los Angeles, CaliforniaY. Tang, University of California at Los Angeles, Los Angeles, California

Precisely integrating multiple different protein ligands into supramolecular assembliesG. A. Hudalla, University of Chicago, Chicago, ILT. Sun, University of Chicago, Chicago, IllinoisJ. H. Collier, University of Chicago, Chicago, Illinois

Orthopaedic Polymers

Thermoluminescence in UV- and X-Irradiated PEEKD. Adhikari, University of Memphis, Memphis, TNT. Riahinasab, University of Memphis, Memphis, TennesseeB. Walters, University of Memphis, Memphis, TennesseeR. Gnawali, University of Memphis, Memphis, Tennessee

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M. S. Jahan, University of Memphis, Memphis, Tennessee

Production and Characterization of Melt-Spun PEEK Fibers for Biomedical ApplicationsE. S. Ouellette, Syracuse University, Syracuse, NYJ. L. Gilbert, Syracuse University, Syracuse, New York

Injectable Lubricants for Prosthetic JointsS. Lee, Technical University of Denmark, Kgs. Lyngby, Denmark

Mechanical and biological analysis of compression molded polyetheretherketone-titanium(PEEK-Ti) compositesH. Park, Department of Materials Science and Engineering, Seoul National University,Seoul, Republic of KoreaH. Jung, Department of Materials Science and Engineering, Seoul National University, Seoul,Republic of KoreaS. Kim, Seoul National Univ., Seoul, Republic of KoreaM. Kang, Department of Materials Science and Engineering, Seoul National University, Seoul,Republic of KoreaH. Kim, Department of Materials Science and Engineering, Seoul National University, Seoul, Republicof KoreaY. Estrin, Department of Materials Engineering, Monash University, Clayton, Australia

Polymerized Biodegradable Cement to Replace Poly(Methyl Methacrylate) in VertebralCompression Fracture Augmentation – a Biomechanical EvaluationB. M. Schlossberg, Pioneer Surgical, Woburn, MA

Optimized Wear Resistance and Toughness of Vitamin E blended, High Temperature Meltedand Radiation Cross-linked UHMWPEB. Doshi, Massachusetts General Hospital, Boston, MAE. Oral, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Vitamin E Does Not Elute Out of Vitamin E-Grafted Ultra High Molecular WeightPolyethyleneM. Guo, Zimmer Inc, Warsaw, INA. Rufner, Zimmer Inc, warsaw, IndianaD. Pletcher, Zimmer Inc, Warsaw, IndianaO. Popoola, Zimmer Inc, Warsaw, IndianaD. Yakimicki, Zimmer Inc, Warsaw, IndianaJ. Rufner, Zimmer Inc., Warsaw, Indiana

Oxidative Analysis of Retrieved Moderately Cross-linked UHMWPE Acetabular BearingsAfter 10 Years In VivoC. Reyes, Massachusetts General Hospital, Boston, MAS. Rowell, Massachusetts General Hospital, Boston, MassachusettsC. A. Engh, Jr., AORI, Alexandria, VirginiaR. Hopper, AORI, Alexandria, VirginiaO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Physical Parameters in the Design of Drug Delivery Systems

Geometry Matters: Cellular Uptake of Nanoscale Drug Carriers is Uniquely Dependent on

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Particle Size and ShapeR. Agarwal, University of Texas at Austin, Austin, TXV. Singh, University of Texas at Austin, Austin, TexasP. Jurney, University of Texas at Austin, Austin, TexasL. Shi, University of Texas at Austin, Austin, TexasS. Sreenivasan, University of Texas at Austin, Austin, TexasK. Roy, University of Texas at Austin, Austin, Texas

Mathematical Modeling of Bi-phasic Mixed Particle Drug Release from NanoparticlesS. S. Hossain, The University of Texas at Austin, Austin, TXS. Hossainy, Abbott Vascular, Santa Clara, CaliforniaD. Davalian, Abbott Vascular, Santa Clara, California

How Different Drugs Affect the Properties, Degradation, and Release Profiles of DrugDelivery FilmsC. L. Rabek, University of Kentucky, Lexington, KYT. D. Dziubla, University of Kentucky, Lexington, KentuckyD. A. Puleo, University of Kentucky, Lexington, Kentucky

Injectable Hydrogels with Controlled Release of Covalently Incorporated DexamethasoneD. Bezuidenhout, University of Cape Town, Cape Town, South AfricaN. H. Davies, University of Cape Town, Cape Town, South AfricaA. Oosthuysen, University of Cape Town, Cape Town, South AfricaP. Zilla, University of Cape Town, Cape Town, South Africa

Food-Associated Stimuli Enhance Barrier Properties of MucusH. Yildiz, Northeastern University, Boston, MAR. L. Carrier, Northeastern University, Boston, Massachusetts

Effect of Processing Temperature on the Morphology and Drug-Release Characteristics ofElastin-Like Polypeptide - Collagen Composite ScaffoldsA. Janorkar, University of Mississippi Medical Center, Jackson, MSN. Patel, University of Mississippi Medical Center, Jackson, Mississippi

The physical properties of particles dominate cellular uptake and subsequent influences oncell functionsZ. Mao, Zhejiang University, China, Hangzhou, China

Effect of Temperature and Size on Release of Calcein from eLiposomesM. Javadi, Brigham Young University, Provo, UT

Surface Modification of Biomaterials for Local Therapy and Diagnostics

Multifunctional Drug-Delivery Nanoparticles for Elastic Matrix Stabilization and Repair inAortic AneurysmsB. Sivaraman, Cleveland Clinic, Cleveland, OHA. Ramamurthi, Cleveland Clinic, Cleveland, Ohio

Magnetic Barcode Assay for Genetic Detection of PathogensM. Liong, Massachusetts General Hospital-Harvard Medical School, Charlestown, MA

Conducting Polymer Microcavities for Controlled Release of Antineoplastic Agents to Brain

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TumorsP. Fattahi, Pennsylvania State University, State College, PAM. R. Abidian, Pennsylvania State University, University Park, Pennsylvania

Co-Delivery of Paclitaxel and Nitric Oxide from Abluminal and Luminal Surfaces of aCoronary StentA. Gallo, The University of South Dakota, Sioux Falls, SD

Development of an in vitro Focal Neuronal Injury Platform With Simultaneous NeuralRecording and Conducting Polymer/Graphene Oxide Nanocomposite-mediatedElectrochemical SensingC. L. Weaver, University of Pittsburgh, Pittsburgh, PAN. R. Snyder, University of Pittsburgh, Pittsburgh, PennsylvaniaT. Cui, University of Pittsburgh, Pittsburgh, Pennsylvania

Bio-Inspired Assembly for Surface Localization of Gadolinium to Improve Relaxivity of anMRI Contrast-Enhancing LiposomeC. E. Smith, University of Illinois at Urbana-Champaign, Urbana, ILH. Kong, University of Illinois at Urbana-Champaign, Urbana, Illinois

CDK Inhibitor PD 0332991 Selectively Inhibits Lung Adenocarcinoma Cells WithoutSacrificing Matrix Embedded Endothelial Cells Regulatory Effect on Tumor ProliferationG. L. A. Cunha, Massachusetts Institute of Technology, Cambridge, MAA. Freiman, Massachusetts Institute of Technology, Cambridge, MassachusettsL. Indolfi, Massachusetts Institute of Technology, Cambridge, MassachusettsN. Artzi, Massachusetts Institute of Technology, Cambridge, MassachusettsJ. L. Dreyfuss, Universidade Federal de São Paulo, São Paulo, BrazilE. R. Edelman, Massachusetts Institute of Technology, Cambridge, Massachusetts

Use of Nanoparticles for Improving Enzyme Stability to Prolong Biosensor FunctionalityG. Zhang, Clemson University, Clemson, SC

Wound Dressings That Do More Than Covering the Wounds

Effectively Inducing and Monitoring Adipose-derived Stem Cells-mediated TissueRegeneration using a PEGylated Fibrin and Gold NanoparticlesE. Chung, The University of Texas at Austin, Austin, TXR. S. Stowers, The University of Texas at Austin, Austin, TexasS. Y. Nam, The University of Texas at Austin, Austin, TexasM. A. Samano, The University of Texas at Austin, Austin, TexasL. M. Ricles, The University of Texas at Austin, Austin, TexasS. Y. Emelianov, The University of Texas at Austin, Austin, TexasL. J. Suggs, The University of Texas at Austin, Austin, Texas

Accelerated Re-epithelialization of Skin Wounds Using Epidermal Growth Factor CoacervateN. Johnson, University of Pittsburgh, Pittsburgh, PAY. Wang, University of Pittsburgh, Pittsburgh, Pennsylvania

Multilayer films addressing bleeding and infectionB. B. Hsu, Massachusetts Institute of Technology, Cambridge, MAP. T. Hammond, Massachusetts Institute of Technology, Cambridge, Massachusetts

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Electrospun Ultralow-fouling Poly(Sulfobetaine Methacrylate) for Nonadherent,Superabsorbent, Antimicrobial, and Reusable Wound DressingsQ. Liu, University of Akron, Akron, OHR. Lalani, University of Akron, Akron, OhioD. Kontoveros, University of Akron, Akron, OhioL. Liu, University of Akron, Akron, Ohio

Disease State Affects Tissue Microenvironment and Material PerformanceN. Oliva, MIT, Cambridge, MA

Quick-Release Medical TapeB. Laulicht, Harvard-MIT Division of Health Sciences and Technology, Cambridge, MAR. Langer, MIT, Cambridge, MassachusettsJ. Karp, Harvard/MIT, Cambridge, Massachusetts

CS8

Biofunctional Polymers for Gene Delivery

Enhancement of colloidal stability of cell signal-responsive gene carriers for disease cell-specific deliveryY. Katayama, Faculty of Engineering, Kyushu University, Fukuoka, JapanS. Kushio, Kyushu University, Fukuoka, JapanC. Kim, Kyushu University, Fukuoka, JapanT. Niidome, Faculty of Engineering, Kyushu University, Fukuoka, JapanT. Mori, Faculty of Engineering, Kyushu University, Fukuoka, Japan

Novel Solution of Nucleic Acid Delivery for in-vivo Diagnosis: Self-assembled NanopiecesH. Yu, Warren Alpert Medical School, Brown University, Providence, RI

Design of Dendrimer-Based System for Delivery of Therapeutic SiRNA for Treating CardiacDiseaseJ. Liu, Georgia Institute of Technology, Atlanta, GAC. Gu, Georgia Institution of Techonology, Atlanta, GeorgiaB. Cabigas, Emory University, Atlanta, HawaiiK. Pendergrass, Emory University, Atlanta, GeorgiaM. Brown, Emory University, Atlanta, GeorgiaY. Luo, Peking University, Beijing, ChinaM. Davis, Georgia Institute of Technology and Emory University, Atlanta, Georgia

The Development of Safe and Effective Polymeric Carriers for SiRNA DeliveryA. R. Shrivats, Carnegie Mellon University, Pittsburgh, PAE. Hsu, Carnegie Mellon University, Pittsburgh, PennsylvaniaA. Watt, Carnegie Mellon University, Pittsburgh, PennsylvaniaS. McBride, Carnegie Mellon University, Pittsburgh, PennsylvaniaS. Liu, Carnegie Mellon University, Pittsburgh, PennsylvaniaP. Alvarez-Urena, Carnegie Mellon University, Pittsburgh, PennsylvaniaS. Averick, Carnegie Mellon University, Pitsburgh, PennsylvaniaH. Cho, Carnegie Mellon University, Pittsburgh, PennsylvaniaE. Paredes, Carnegie Mellon University, Pittsburgh, Pennsylvania

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S. R. Das, Carnegie Mellon University, Pittsburgh, PennsylvaniaK. Matyjaszewski, Carnegie Mellon University, Pittsburgh, PennsylvaniaJ. O. Hollinger, Carnegie Mellon University, Pittsburgh, Pennsylvania

A Versatile Coiled-coil Tethering System for the Biofunctionalization of Recharged GeneDelivery VectorsC. Fortier, Ecole Polytechnique de Montreal, Montreal, QC, CanadaB. Liberelle, Ecole Polytechnique de Montreal, Montreal, Québec, CanadaY. Durocher, CNRC-NRC Montreal-Royalmount, Montreal, Québec, CanadaG. De Crescenzo, Ecole Polytechnique de Montreal, Montreal, Québec, Canada

Polysialic Acid-N-Trimethyl Chitosan Nanoparticles for Oligonucleotide DeliveryP. R. Wardwell, Syracuse University, Syracuse, NYR. M. Iyer, Syracuse University, Syracuse, New YorkP. N. Borer, Syracuse University, Syracuse, New YorkM. McPike, Aptamatrix, Syracuse, New YorkM. B. Forstner, Syracuse University, Syracuse, New YorkR. A. Bader, Syracuse University, Syracuse, New York

Targeted Delivery of micro-RNA by Ephrin-A1 Conjugated Nanoliposomal Particles (NLP)for Malignant pleural MesotheliomaH. Lee, University of Florida, Gainesville, FL

MicroRNA 29a Inhibitor Loaded Gelatin Nanofibers for Localized Gene TherapyE. N. James, University of Connecticut Health Center, Middletown, CTA. M. Delany, University of Connecticut Health Center, Farmington, ConnecticutL. S. Nair, University of Connecticut Health Center, Farmington, Connecticut

Cardiovascular Biomaterials2

Peptide-grafted Poly(ethylene glycol) Hydrogels Support Endothelial Progenitor Cell Rollingand Adhesion Under ShearW. Seeto, Auburn University, Auburn, ALY. Tian, Polytechnic Institute of New York University, Auburn, AlabamaE. A. Lipke, Auburn University, Auburn, Alabama

A non-toxic additive to introduce X-ray contrast into poly(lactic acid). Implications fortransient medical implants such as bioresorbable coronary vascular scaffoldsY. Wang, Maastricht University, Maastricht, NetherlandsL. H. Koole, Maastricht University, Maastricht, Netherlands

MSCs Enhanced Endothelial Regeneration and Reduced Fibrosis on Bioengineered VascularGraftW. Tan, University of Colorado, Boulder, CO

Small-Diameter Biodegradable Vascular Grafts Mechanical Characterization and TissueInteractionsA. Melchiorri, University of Maryland, College Park, MDZ. R. Brandes, University of Maryland, College Park, MarylandN. Hibino, Children's National Medical Center, District of Columbia, District of ColumbiaJ. P. Fisher, University of Maryland, College Park, Maryland

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Degradable polar hydrophobic ionic polyurethane promotes endothelial and wound healingphenotype of circulating angiogenic cellsE. S. Mathieu, University of Ottawa Heart Institute, Ottawa, ON, Canada

Aortic tissue-stent mechanical interaction in transcatheter aortic valve replacementJ. Mummert, University of Connecticut, Storrs, CTE. Sirois, University of Connecticut, Storrs, ConnecticutW. Sun, University of Connecticut, Storrs, Connecticut

Introducing a polymeric device for the treatment of Abdominal Aortic Aneurysms: Designand in vitro performanceD. Cohn, The Hebrew University of Jerusalem, Jerusalem, IsraelA. Bloom, Hadassah University Medical Center, Jerusalem, Israel

Reconfigurable Biodegradable Shape-memory Elastomers using “click” ChemistryS. Ninh, Carnegie Mellon University, Pittsburgh, PAC. Bettinger, Carnegie Mellon University, Pittsburgh, Pennsylvania

Nanomaterials

Non-Invasive Diagnosis of Intracerebral Hemorrhage Using Iodinated LiposomalNanocarriersK. McNeeley, Georgia Institute of Technology, Atlanta, GAK. McNeeley, Georgia Institute of Technology, Atlanta, GeorgiaR. Bellamkonda, Georgia Institute of Technology, Atlanta, Georgia

Synthesis of Solid Lipid Nanoparticles and their Interaction with SkinX. Calderon-Colon, The Johns Hopkins University Applied Physics Laboratory, Laurel, MDM. W. Patchan, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandM. L. Theodore, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandH. T. Le, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandJ. L. Sample, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandJ. J. Benkoski, The Johns Hopkins University Applied Physics Laboratory, Laurel, MarylandJ. B. Patrone, The Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland

Intracellular dynamics of oligopeptide-modified phospholipid polymer nanoparticlesK. ISHIHARA, The University of Tokyo, Tokyo, Japan

Surface Characterization of Functionalized Gold NanoparticlesL. Gamble, University of Washington, Seattle, WAA. Rafati, University of Washington, Seattle, WashingtonS. D. Techane, University of Washington, Seattle, WashingtonD. G. Castner, University of Washington, Seattle, Washington

Composite Biomaterials Active against Opportunistic PathogensM. D. Leonida, Fairleigh Dickinson University, Teaneck, NJA. Benzecry, Fairleigh Dickinson University, Teaneck, New JerseyA. Suria, Fairleigh Dickinson University, Teaneck, New Jersey

Reduced Adhesion of Staphylococcus aureus to ZnO/PVC NanocompositesB. M. Geilich, Northeastern University, Brookline, MAT. J. Webster, Northeastern University, Boston, Massachusetts

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Cecropin-mellitin modified surfaces exhibit high antimicrobial activity and low cytotoxicityagainst human cellsM. B. Evangelista, BIOCANT - Technology Transfer Association and CNC - Center forNeuroscience and Cell Biology, Cantanhede, PortugalA. Rai, Biocant - Parque Tecnologico de Cantanhede and CNC - Center for Neuroscience and CellBiology, Cantanhede, PortugalM. B. Evangelista, Biocant - Parque de Tecnologico de Cantanhede and CNC - Center forNeuroscience and Cell Biology, Cantanhede, PortugalS. Pinto, CNC - Center for Neuroscience and Cell Biology, Cantanhede, PortugalL. S. Ferreira, Biocant - Parque Tecnologico de Cantanhede and CNC - Center for Neuroscience andCell Biology, Cantanhede, Portugal

Multivalent Gd-DOTA Decorated Starlike Amphiphilic Dextran Micelles as Sensitive MRIProbesH. Ai, Sichuan University, Chengdu, ChinaH. Su, Sichuan University, Chengdu, ChinaD. Li, Sichuan University, Chengdu, ChinaC. Wu, Sichuan University, Chengdu, ChinaC. Xia, Sichuan University, Chengdu, ChinaQ. Gong, Sichuan University, Chengdu, ChinaB. Song, Sichuan University, Chengdu, China

The Role of Antioxidants in Biomaterials

The Efficacy of Vitamin E and a Hindered Amine Light Stabilizer in stabilizing UHMWPE fromOxidationA. Bellare, Brigham & Women's Hospital, Harvard Medical School, Boston, MA

Collagen and Elastin Binding Polyphenols Protect Scaffolds and Stem Cells from Diabetes-Related ComplicationsJ. P. Chow, Clemson University, Clemson, SC

Extraction Analysis of Vitamin E-Grafted PolyethyleneS. Spiegelberg, Cambridge Polymer Group, Inc., Boston, MAN. Turner, Cambridge Polymer Group, Boston, MassachusettsT. Wilson-Hill, Cambridge Polymer Group, Boston, MassachusettsD. Pletcher, Zimmer, Inc., Warsaw, IndianaA. Rufner, Zimmer, Inc., Warsaw, Indiana

Antioxidant Cerium Oxide Nanoparticle Composite Hydrogels for Islet Encapsulation andProtectionJ. D. Weaver, University of Miami, Miami, FLC. L. Stabler, University of Miami, Miami, Florida

Reducing Lipid Absorption in Highly Crosslinked Grafted Vitamin E PolyethyleneD. Pletcher, Zimmer, Inc, Warsaw, INA. Rufner, Zimmer, Inc, Warsaw, Indiana

Microparticulate Formulations of Antioxidant Poly(β-Amino Ester) Polymers for WoundHealing ApplicationsN. M. Shah, University of Kentucky, Lexington, KY

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S. H. Deschamp, University of Kentucky, Lexington, KentuckyJ. Hilt, University of Kentucky, Lexington, KentuckyT. D. Dziubla, University of Kentucky, Lexington, Kentucky

Surface Characterization and Modification2

Development of new toxin-adsorbing and hemocompatible surfaces as a step towards aminiaturized artificial kidneyJ. H. Janssen, Maastricht University and INterface BIOmaterials BV, Geleen, Netherlands

Development of a Catheter-Deployable Device for the Capture of Rare Analytes in BloodJ. C. Sy, Massachusetts Institute of Technology, Cambridge, MAJ. Fernandez Esmerats, Massachusetts Institute of Technology, Cambridge, MassachusettsA. E. Wisniowska, Massachusetts Institute of Technology, Cambridge, MassachusettsJ. M. Milwid, Massachusetts Institute of Technology, Cambridge, MassachusettsM. J. Cima, Massachusetts Institute of Technology, Cambridge, Massachusetts

Bioactive coatings for vascular implants: a promising strategy using oriented tethering ofEGF on chondroitin sulfateP. Lequoy, Ecole de Technologie Supérieure, Montreal, QC, CanadaB. Liberelle, Ecole Polytechnique de Montreal, Montreal, Québec, CanadaC. Fortier, Ecole Polytechnique de Montreal, Montreal, Québec, CanadaG. De Crescenzo, Ecole Polytechnique de Montreal, Montreal, Québec, CanadaS. Lerouge, Ecole de Technologie Superieure, Montreal, Québec, Canada

Development of Viral Nanoparticle Networks and Hybrids for Enhanced Tumor Homing andPenetrationA. M. Wen, Case Western Reserve University, Cleveland, OHN. F. Steinmetz, Case Western Reserve University, Cleveland, Ohio

Precisely Designed Thermo-responsive Polymer Brush Surface for Cell SeparationK. Nagase, Tokyo Women's Medical University, Tokyo, JapanA. Kimura, Waseda University, Tokyo, JapanY. Hatakeyama, Waseda University, Tokyo, JapanT. Shimizu, Tokyo Women's Medical University, Tokyo, JapanK. Matsuura, Tokyo Women's Medical University, Tokyo, JapanM. Yamato, Tokyo Women's Medical University, Tokyo, JapanN. Takeda, Waseda University, Tokyo, JapanT. Okano, Tokyo Women's Medical University, Tokyo, Japan

Ultrathin Surface Coating of Thermoresponsive Block Copolymers for Fabricating CellSheetsM. Nakayama, Tokyo Women's Medical University, Tokyo, JapanY. Kimura, Keio University, Tokyo, JapanN. Yamada, Keio University, Tokyo, JapanH. Kanazawa, Keio University, Tokyo, JapanT. Okano, Tokyo Women’s Medical University, Tokyo, Japan

Robust Photolabile Physically Crosslinked Polymer NetworksC. Zhu, Carnegie Mellon University, Pittsburgh, PAC. Bettinger, Carnegie Mellon University, Pittsburgh, Pennsylvania

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Slippery When Wet: Gradient Surface Functionalization of Hydrogels for Lubricity ControlB. A. Krick, University of Florida, Gainesville, FLA. A. Pitenis, University of Florida, Gainesville, FloridaA. C. Dunn, University of Florida, Gainesville, FloridaW. Sawyer, University of Florida, Gainesville, Florida

Tissue Engineering 2

Dose Response to TGF-β3 of Co-Cultured Chondrocytes and Mesenchymal Stem Cells onPorous Polymer ScaffoldsR. L. Dahlin, Rice University, Houston, TXM. Ni, Rice University, Houston, TexasV. V. Meretoja, Rice University, Houston, TexasF. K. Kasper, Rice University, Houston, TexasA. G. Mikos, Rice University, Houston, Texas

Heparin-containing Hydrogels for Sustained Release of Cathepsin Inhibitors for Treatmentof Tendon DegenerationS. P. Seto, Georgia Institute of Technology, Atlanta, GAT. Miller, Georgia Institute of Technology, Atlanta, GeorgiaY. Qiu, Georgia Institute of Technology, Atlanta, GeorgiaM. O. Platt, Georgia Institute of Technology, Atlanta, GeorgiaJ. S. Temenoff, Georgia Institute of Technology, Atlanta, Georgia

Effects of Ceramic Structural Properties on Chondrocyte ResponseM. K. Boushell, Columbia University, New York, NYR. Z. LeGeros, New York University, New York, New YorkH. H. Lu, Columbia University, New York, New York

Cartilage Tissue Engineering with Silk Fibroin Scaffolds Fabricated by Indirect AdditiveManufacturing TechnologyV. Shyu, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine,Taoyuan, Taiwan, Tao-Yuan, Taiwan

Co-electrospun Scaffolds with Gradients in Fiber Alignment and Chemistry for theRegeneration of Ligament-Bone TransitionsA. R. Whittington, Virginia Polytechnic Institute and State University, Blacksburg, VAS. Samavedi, Virginia Polytechnic Institute and State University, Blacksburg, VirginiaP. Gaddam, Virginia Polytechnic Institute and State University, Blacksburg, VirginiaA. R. Whittington, Virginia Polytechnic Institute and State University, Blacksburg, VirginiaA. S. Goldstein, Virginia Polytechnic Institute and State University, Blacksburg, Virginia

Micropatterned co-cultures of endothelial cells and mesenchymal stem cells within gelatinmethacrylate hydrogelsM. Nikkhah, Harvard Medical School, Cambridge, MA

Electrospun Bilayered Vascular Scaffolds for Engineering Small Diameter Blood VesselsS. Lee, Wake Forest School of Medicine, Winston-Salem, NC

Novel Bioactive Coatings to Improve Allograft Incorporation Evaluated in eGFP ChimericRatsA. Das, University of Virginia, Charlottesville, VA

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Y. Lin, University of Virginia, Charlottesville, VirginiaQ. Cui, University of Virginia, Charlottesville, VirginiaE. Botchwey, Gatech, Atlanta, Georgia

Tribocorrosion of Metallic Biomaterials

Adverse Tissue Response to Corrosion and Products of Corrosion in CoCr Dual-ModularNeck Hip ProsthesesD. J. Hall, Rush University Medical Center, Chicago, ILR. M. Urban, Rush University Medical Center, Chicago, IllinoisH. J. Cooper, Rush University Medical Center, Chicago, IllinoisJ. L. Wright, Rush University Medical Center, Chicago, IllinoisE. L. Dahlmeier, Rush University Medical Center, Chicago, IllinoisJ. J. Jacobs, Rush University Medical Center, Chicago, Illinois

Prediction of Voltage Shifts During Fretting Corrosion of Titanium Alloy: Effect of Area,Impedance and MechanicsY. Liu, Biomedical and Chemical Engineering Department, Syracuse Biomaterials Institute,Syracuse University, Syracuse, NY,, Syracuse, NYS. Mali, Biomedical and Chemical Engineering Department, Syracuse Biomaterials Institute,SyracuseUniversity, Syracuse, New YorkJ. Gilbert, Biomedical and Chemical Engineering Department, Syracuse BiomaterialsInstitution,Syracuse University, Syracuse, New York

Wear-corrosion Synergism under Fretting and Sliding Contacts in Hip ProsthesisM. T. Mathew, Rush University Medical Center, Chicago, IL

Study of bio-tribocorrosion behavior of Ti6Al4V alloys colonized with osteoblastic-like cellsfor metal hip prosthesisM. J. C. Runa, University of Minho, Guimarães, PortugalM. H. R. Fernandes, University of Porto, Faculty of Dental Medicine, Porto, PortugalM. M. T. Mathew, Rush University Medical Center, Chicago, IllinoisL. A. S. Rocha, University of Minho, Guimaraes, Portugal

Fretting Corrosion Performance Test of Spinal Screw and Rod Constructs: Effect ofStainless Steel –Titanium CombinationS. A. MALI, SYRACUSE UNIVERSITY, Syracuse, NY

Tribocorrosion Behavior of Anodic Titanium Oxide Films and Assessment of Cell-MaterialsInteractionsS. A. Alves, University of Minho, Guimaraes, PortugalR. Bayón, Fundación IK4-Tekniker, Eibar, SpainV. S. de Viteri, Fundación IK4-Tekniker, Eibar, SpainM. P. Garcia, Faculty of Dental Medicine of Porto University, Porto, PortugalA. Igartua, Fundación IK4-Tekniker, Eibar, SpainM. H. Fernandes, Faculty of Dental Medicine of Porto University, Porto, PortugalL. A. Rocha, University of Minho, Guimaraes, Portugal

Quartz crystal mass monitoring to study tribofilm formation and retention in self-matingCoCrMo systemsR. Pourzal, Rush University Medical Center, Chicago, IL

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Hydroxyapatite Coated Porous Magnesium with for Biomedical ApplicationsM. Kang, Department of Materials Science and Engineering, Seoul National University,Seoul, Republic of Korea, Seoul, Republic of Korea

CS9

Biomaterial Strategies for Large-Area Bone Regeneration

Scaffold Optimization and Pre-Vascularization Strategies for Large-Area Bone RegenerationA. R. Amini, University of Connecticut Health Center, Farmington, CTC. T. Laurencin, University of Connecticut Health Center, Farmington, ConnecticutS. P. Nukavarapu, University of Connecticut Health Center, Farmington, Connecticut

Biomimetic Citrate-Presenting Osteoinductive CompositesR. T. Tran, The Pennsylvania State University, University Park, PAC. Zhang, The University of Texas at Arlington, Arlington, TexasB. Banik, The Pennsylvania State University, University Park, PennsylvaniaJ. L. Brown, The Pennsylvania State University, University Park, PennsylvaniaJ. Yang, The Pennsylvania State University, University Park, Pennsylvania

Development of Bioactive Glass Scaffolds for Segmental Bone RepairM. N. Rahaman, Missouri University of Science and Technology, Rolla, MO

A novel magnesium-based bone substitutes: An alternative to autologous bone grafting totreat large bone defectsK. W. K. Yeung, The University of Hong Kong, Hong Kong, Hong KongK. H. M. Wong, The University of Hong Kong, Hong Kong, Hong KongP. K. Chu, City University of Hong Kong, Hong Kong, Hong KongK. D. K. Luk, The University of Hong Kong, Hong Kong, Hong KongK. M. C. Cheung, The University of Hong Kong, Hong Kong, Hong Kong

Tethered Epidermal Growth Factor delivery for the repair of large segmental bone defectsJ. J. Rivera, Massachusetts Institute of Technology, Cambridge, MAM. Rodrigues, University of Pittsburgh, Pittsburgh, PennsylvaniaV. Raut, Cleveland Clinic, Cleveland, OhioL. M. Alvarez, Massachusetts Institute of Technology, Cambridge, MassachusettsL. Stockdale, Massachusetts Institute of Technology, Cambridge, MassachusettsA. Nuschke, University of Pittsburgh, Pittsburgh, PennsylvaniaC. Boehm, Cleveland Clinic, Cleveland, OhioD. Stolz, University of Pittsburgh, Pittsburgh, PennsylvaniaA. Wells, University of Pittsburgh, Pittsburgh, PennsylvaniaG. F. Muschler, Cleveland Clinic, Cleveland, OhioL. Griffith, Massachusetts Institute of Technology, Cambridge, Massachusetts

Integrin-Specific Hydrogels for the Delivery of Human Mesenchymal Stem Cells in BoneRepairA. Y. Cheng, Georgia Institute of Technology, Atlanta, GAA. Shekaran, Georgia Institute of Technology, Atlanta, GeorgiaA. J. Garcia, Georgia Institute of Technology, Atlanta, Georgia

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Biomaterial-Mediated Delivery of Uncultured Rat Bone Marrow Mononuclear Cells andCulture-Expanded Mesenchymal Stem Cells for Large Bone Defect HealingJ. K. Wise, University of Michigan, Ann Arbor, MIA. I. Alford, University of Michigan, Ann Arbor, MichiganJ. P. Stegemann, University of Michigan, Ann Arbor, Michigan

MSC Localization via Tissue Engineered Periosteum Mimetics Coordinates Remodeling ofBone AllograftsM. Hoffman, University of Rochester, Rochester, NYC. Xie, University of Rochester, Rochester, New YorkD. Benoit, University of Rochester, Rochester, New York

Biomaterials for Modulating Immune and Inflammatory Processes2

Development of novel imaging probes for the detection of polarized macrophage subsetsduring foreign body reactionsD. W. Baker, University of Texas at Arlington, Coppell, TXJ. Zhou, University of Texas at Arlington, Arlington, TexasY. Tsai, University of Texas at Arlington, Arlington, TexasK. Patty, University of Texas at Arlington, Arlington, TexasH. Weng, University of Texas at Arlington, Arlington, TexasE. N. Tang, University of Texas at Arlington, Arlington, TexasL. Tang, University of Texas at Arlington, Arlington, Texas

The Immune Response to Xenogeneic Acellular Biologic Scaffold MaterialsR. Londono, University of Pitttsburgh, Pittsburgh, PAT. J. Keane, University of Pittsburgh, Pittsburgh, PennsylvaniaB. M. Brown, University of Pittsburgh, Pittsburgh, PennsylvaniaM. T. Wolf, University of Pittsburgh, Pittsburgh, PennsylvaniaS. F. Badylak, University of Pittsburgh, Pittsburgh, Pennsylvania

Single dose polyanhydride nanoparticle-based vaccine safely induces both cellular andhumoral immunityS. Haughney, Iowa State University, Ames, IAY. Phanse, Iowa State University, Ames, IowaL. Petersen, Iowa State University, Ames, IowaA. Ramer-Tait, Iowa State University, Ames, IowaJ. Hostetter, Iowa State University, Ames, IowaB. Narasimhan, Iowa State University, Ames, IowaM. Wannemuehler, Iowa State University, Ames, Iowa

Sphingosine 1-phosphate receptor three regulates implant arteriogenesis by recruitmentand localization of anti-inflammatory monocytes to surrounding microvesselsA. O. Awojoodu, Georgia Institute of Technology, Atlanta, GA

Macrophage-Targeted Alginate Nanoparticles as a Non-Condensing Murine IL-10 GeneDelivery System for the Treatment of Experimental ArthritisS. Jain, Northeastern University, Boston, MAM. M. Amiji, Northeastern University, Boston, Massachusetts

The Influence of Keratin Biomaterial Treatment on Macrophage Phenotype in Spinal CordInjury

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B. Fearing, Wake Forest University Health Sciences, Winston-Salem, NC

Immunotherapy with Shear-thinning Injectable Hydrogels to Treat ObstructiveNephropathyD. E. Soranno, Children's Hospital of Philadelphia, Philadelphia, PAH. D. Lu, University of Pennsylvania, Philadelphia, PennsylvaniaH. M. Weber, University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Engineering Dendritic Cell Environments To Reduce Transplant Rejection By Induction OfImmune Tolerance.S. Srinivasan, Georgia Institute of Technology, Atlanta, GAG. Patel, Georgia Institute of Technology, Atlanta, GeorgiaU. (. Goh, Georgia Institute of Technology, Atlanta, GeorgiaJ. E. Babensee, Georgia Institute of Technology, Atlanta, Georgia

Biomaterials in the Fourth Dimension – Controlling Temporal Properties

Dynamic Cell Culture on Shape Changing MicropatternsK. A. Davis, Syracuse University, Syracuse, NYJ. H. Henderson, Syracuse University, Syracuse, New York

Shape-memory Cell Culture Surfaces with Dynamically Tunable NanopatternsM. Ebara, National Institute for Materials Science, Tsukuba, JapanT. Aoyagi, National Institute for Materials Science, Tsukuba, Japan

Sequential Growth Factor Delivery within Fibrin Loaded Porous Degradable HydrogelsB. Jiang, Illinois Institute of Technology, Chicago, ILB. Akar, Illinois Institute of Technology, Chicago, IllinoisT. Waller, Illinois Institute of Technology, Chicago, IllinoisJ. Larson, Illinois Institute of Technology, Chicago, IllinoisA. Appel, Illinois Institute of Technology, Chicago, IllinoisE. Brey, Illinois Institute of Technology, Chicago, Illinois

Fibrous Hyaluronic Acid Scaffolds with Engineered Degradation through MMP SensitivityR. Wade, University of Pennsylvania, Philadelphia, PAJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Facile preparation of phododegradable hydrogel by photo-mediated crosslinkingC. Ki, Indiana University-Purdue University Indianapolis, Indianapolis, INH. Shih, Indiana University-Purdue University Indianapolis, Indianapolis, IndianaC. Lin, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana

Clickable, Photodegradable Cell Culture Scaffolds to Modulate Valvular Interstitial CellPhenotype In SituC. M. Kirschner, University of Colorado, Boulder, COC. M. Kirschner, University of Colorado, Boulder, ColoradoD. L. Alge, University of Colorado, Boulder, ColoradoS. T. Gould, University of Colorado, Boulder, ColoradoK. S. Anseth, University of Colorado, Boulder, Colorado

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Biomimetic Surfaces: From Multi-scale Fabrication Methods to Diagnostic, Therapeuticand Clinical Applications

Longitudinal Monitoring of Biomaterial-associated Inflammation and Bacterial Infection ina Minimally Invasive FashionS. Suri, Georgia Institute of Technology, Smyrna, GAS. Selvam, Georgia Institute of Technology, Trivandrum, IndiaS. M. Lehman, Georgia Institute of Technology, Atlanta, GeorgiaK. Reddie, Georgia Institute of Technology, Atlanta, GeorgiaN. Murthy, University of California Berkeley, Berkeley, CaliforniaA. J. Garcia, Georgia Institute of Technology, Atlanta, Georgia

Biomimetic Mineralization of Acid Polysaccharide-based Hydrogels: Inspiration from RecentFindings about Organic/mineral Interface in BoneC. Zhong, Sr., Cornell University, Ithaca NY, NYC. Chu, Cornell University, Ithaca, New York

Polar Opposite Functions of the North American Porcupine Quill and Quill-mimetic MedicalDevicesW. Cho, MIT, Cambridge, MAJ. Ankrum, MIT, Cambrisge, MassachusettsD. Guo, Brigham and Women's Hospital, Cambridge, MassachusettsS. Chester, MIT, Cambridge, MassachusettsS. Yang, Brigham and Women's Hospital, Cambridge, MassachusettsA. Kashyap, Brigham and Women's Hospital, Cambridge, MassachusettsG. Campbell, Brigham and Women's Hospital, Cambridge, MassachusettsR. Wood, Harvard University, Cambridge, MassachusettsR. Rijal, Brigham and Women's Hospital, Cambridge, MassachusettsR. Karnik, MIT, Cambridge, MassachusettsR. Langer, MIT, Cambridge, MassachusettsJ. Karp, Brigham and Women's Hospital, Cambridge, Massachusetts

Internal Stress in Biomimetic Coatings due to Cell-Material InteractionsL. Yang, The First Affiliated Hospital of Soochow University, Suzhou, ChinaL. Zhang, Brown University, Providence, Rhode IslandB. W. Sheldon, Brown University, Providence, Rhode IslandT. J. Webster, Brown University, Providence, Rhode Island

Specificity of Adsorption in a Prototype Whole Blood Affinity Therapy Device for Removal ofStaphylococcus aureusR. S. Ward, Exthera Medical Corporation, Berkeley, CA

Using Biomimetic Protein Micropatterns to Guide Mesenchymal Stem Cell DifferentiationA. Shukla, Rice University, Houston, TXJ. West, Duke University, Durham, North Carolina

Calcium Phosphate Composite as Stem Cells Delivery Vehicle for Bone RepairJ. Chang, ETEX Corporation, Cambridge, MA

Multifunctional Matrix Self-Assembled from Matrilin-3 and Rosette Nanotubes for CartilageRepairY. Chen, Rhode Island Hospital/Alpert Medical School, Brown University, Providence, RI

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Drug Delivery3

Hyaluronic Acid - Gold Nanoparticle/Interferon α Complex for Targeted Treatment ofHepatitis C Virus InfectionS. Hahn, Pohang University of Science and Technology (POSTECH), pohang, Republic ofKoreaM. Lee, POSTECH, Pohang, Republic of KoreaJ. Yang, POSTECH, pohang, Republic of KoreaH. Jung, POSTECH, pohang, Republic of KoreaW. Hur, The Catholic University, Seoul, Republic of KoreaS. Yoon, The Catholic University, Seoul, Republic of Korea

Evaluating Cellular Interactions of Polyanhydride Particles for Intracellular Delivery ofAntibioticsB. Narasimhan, Iowa State Univesrity, Ames, IAY. Phanse, Iowa State University, Ames, IowaP. A. Lueth, Iowa State University, Ames, IowaA. E. Ramer-Tait, University of Nebraska–Lincoln, Lincoln, NebraskaB. R. Carrillo-Conde, University of Texas Austin, Austin, TexasB. Narasimhan, Iowa State University, Ames, IowaM. J. Wannemuehler, Iowa State University, Ames, IowaB. H. Bellaire, Iowa State University, Ames, Iowa

Quantitative In vitro 3D Analysis of Nanomaterial Diffusion in a 3D-Atherosclerosis ModelP. Chetprayoon, Graduate School of Engineering, Osaka University, Osaka, JapanM. Matsusaki, Graduate School of Engineering, Osaka University, Osaka, JapanM. Akashi, Graduate School of Engineering, Osaka University, Osaka, Japan

Understanding the Influence of Stent Design on Arterial Drug Distribution and Effectthrough Computational ModelingR. A. Tzafriri, CBSET Inc, Lexington, MAE. R. Edelman, MIT, Cambridge, Massachusetts

Surface Modification of Red Blood Cells Using Novel Plasma Membrane AnchorsS. Pandya, University of Texas at San Antonio, san antonio, TXM. Salinas, University of Texas at San Antonio, San Antonio, TexasE. Abdelaziz, University of Texas at San Antonio, san antonio, TexasG. Negrete, University of Texas at San Antonio, san antonio, TexasC. Agrawal, University of Texas at San Antonio, san antonio, Texas

Polymeric Microparticles for Controlled Fibrolysis in Abdominal Aortic Aneurysms (AAAs)B. Sivaraman, Cleveland Clinic Foundation, Cleveland, OHA. Sylvester, Case Western Reserve University & Cleveland Clinic, Cleveland, OhioA. Ramamurthi, Cleveland Clinic, Cleveland, Ohio

Controlled release of novel anti-biofilm agents from a poly (2-hydroxyethyl methacrylate)Scaffold for the treatment of medical device associated bacterial biofilm infectionsh. ma, university of washington, Seattle, WA

Synthesis of Antimicrobial Monomers Using CiprofloxacinY. Delaviz, University of Toronto, Toronto, ON, CanadaM. W. Laschuk, University of Toronto, Toronto, Ontario, Canada

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M. Yang, University of Toronto, Toronto, Ontario, CanadaJ. Santerre, University of Toronto, Toronto, Ontario, Canada

Engineering Cells and Their Microenvironments

The Role of Cell Shape in Macrophage PolarizationF. Y. N. McWhorter, University of California, Irvine, Irvine, CA

Cell Interaction Distance Modulates Chondrocyte Responses on Co-Cultured ScaffoldsX. Zhang, Columbia University, New York, NYK. L. Moffat, Columbia University, New York, New YorkS. E. Gordon, Columbia University, New York, New YorkN. H. Goldhaber, Columbia Univeristy, New York, New YorkH. H. Lu, Columbia University, New York, New York

Microencapsulation of Beta Cell Spheroids for Treatment of Type 1 DiabetesX. Liu, Clemson University, Richmond, VAX. Wen, Virginia Commenwealth University, Richmond, Virginia

Integration of Microfabricated Channels and Self-assembled Microvasculature to SupportEngineered Hepatic TissueS. J. Higbee, Rice University, Houston, TXM. P. Cuchiara, Rice University, Houston, TexasJ. L. West, Duke University, Houston, Texas

Phosphorylating apatite-specific peptide inhibits osteoblast mineralizationJ. Ramaswamy, University of Michigan Ann Arbor, Ann Arbor, MIH. Nam, University of Michigan Ann Arbor, Ann Arbor, MichiganN. E. Hatch, University of Michigan Ann Arbor, Ann Arbor, MichiganD. H. Kohn, University of Michigan Ann Arbor, Ann Arbor, Michigan

Osteogenic differentiation of ASC and MSC in modular protein/ceramic microenvironmentsR. R. Rao, University of Michigan, Ann Arbor, MIR. R. Rao, University of Michigan, Ann Arbor, MichiganA. W. Peterson, University of Michigan, Ann Arbor, MichiganJ. P. Stegemann, University of Michigan, Ann Arbor, Michigan

Cell Cycle Unification Based on Tuning of Cellular Environments Using Cytocompatible andReversible Forming Phospholipid Polymeric HydrogelsH. Oda, The University of Tokyo, Tokyo, JapanT. Konno, The University of Tokyo, Tokyo, JapanK. Ishihara, The University of Tokyo, Tokyo, Japan

3D hydrogel fibers based system to design heterotypic bone vascularization approachesS. M. Mihaila, 3B's Research Group, Caldas das Taipas - Guimarães, PortugalE. G. Popa, 3B's Research Group, Caldas das Taipas - Guimarães, PortugalR. L. Reis, 3B's Research Group, Caldas das Taipas - Guimarães, PortugalA. P. Marques, 3B's Research Group, Caldas das Taipas - Guimarães, PortugalM. E. Gomes, 3B's Research Group, Caldas das Taipas - Guimarães, Portugal

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Surgical Meshes - Recent Development and Application

Polypropylene Surgical Mesh Coated with Extracellular Matrix Mitigates the Host ForeignBody ResponseM. T. Wolf, University of Pittsburgh, Pittsburgh, PAM. T. Wolf, University of Pittsburgh, Pittsburgh, PennsylvaniaC. A. Carruthers, University of Pittsburgh, Pittsburgh, PennsylvaniaC. L. Dearth, University of Pittsburgh, Pittsburgh, PennsylvaniaP. M. Crapo, University of Pittsburgh, Pittsburgh, PennsylvaniaA. Huber, University of Pittsburgh, Pittsburgh, PennsylvaniaO. A. Burnsed, University of Pittsburgh, Pittsburgh, PennsylvaniaR. Londono, University of Pittsburgh, Pittsburgh, PennsylvaniaS. A. Johnson, University of Pittsburgh, Pittsburgh, PennsylvaniaK. A. Daly, University of Pittsburgh, Pittsburgh, PennsylvaniaE. C. Stahl, University of Pittsburgh, Pittsburgh, PennsylvaniaJ. M. Freund, University of Pittsburgh, Pittsburgh, PennsylvaniaC. J. Medberry, University of Pittsburgh, Pittsburgh, PennsylvaniaL. E. Carey, University of Pittsburgh, Pittsburgh, PennsylvaniaA. Nieponice, University of Pittsburgh, Pittsburgh, PennsylvaniaN. J. Amoroso, University of Pittsburgh, Pittsburgh, PennsylvaniaS. F. Badylak, University of Pittsburgh, Pittsburgh, Pennsylvania

Development of Automated Loom for Woven Tissue Engineering Test SystemsJ. Gilmore, Clemson University, Clemson, SC

Histological Evaluation of Abdominal Wall Defect Repair with a Novel Warp-Knit MeshG. Hilas, Poly-Med, Inc., Anderson, SCS. Peniston, Poly-Med, Inc., Anderson, South CarolinaJ. Corbett, Poly-Med, Inc., Anderson, South Carolina

Evaluation of a Polyamide-Gelatin Mesh seeded with Human Endometrial MesenchymalStem Cells for the repair of Pelvic Organ ProlapseJ. A. M. Ramshaw, CSIRO - Materials Science and Engineering, Clayton, AustraliaD. Ulrich, Monash Institute of Medical Research, Clayton, AustraliaS. L. Edwards, CSIRO - Materials Science and Engineering, Clayton, AustraliaJ. F. White, CSIRO - Materials Science and Engineering, Clayton, AustraliaC. Su, CSIRO - Materials Science and Engineering, Clayton, AustraliaK. Tan, Monash Institute of Medical Research, Clayton, AustraliaA. Rosamilia, Monash University, Calyton, AustraliaC. E. Gargett, Monash Institute of Medical Research, Clayton, AustraliaJ. A. Werkmeister, CSIRO - Materials Science and Engineering, Clayton, Australia

In Vitro Cellular Response to Surgical Mesh Materials Derived from Dermal ECMK. M. Kulig, Massachusetts General Hospital, Boston, MAX. Luo, Massachusetts General Hospital, Boston, MassachusettsE. B. Finkelstein, Massachusetts General Hospital, Boston, MassachusettsX. Liu, Kensey Nash Corporation, Exton, PennsylvaniaJ. P. Vacanti, Massachusetts General Hospital, Boston, MassachusettsS. Goldman, Kensey Nash Corporation, Exton, PennsylvaniaC. A. Sundback, Massachusetts General Hospital, Boston, MassachusettsC. M. Neville, Massachusetts General Hospital, Boston, Massachusetts

Potential utility of woven flax fiber meshes in surgical repair of incisional herniasS. A. A. Michel, Maastricht University, Maastricht, Netherlands

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M. L. W. Knetsch, Maastricht University, Maastricht, NetherlandsD. G. Molin, Maastricht University, Maastricht, NetherlandsL. H. Koole, Maastricht University, Maastricht, Netherlands

Differentiation by FT-IR of Absorbable Polyesters Used in Production of Surgical MeshesK. D. Gray, Jr., Poly-Med, Inc., Anderson, SCC. Culbreath, Poly-Med, Inc., Anderson, South CarolinaJ. Corbett, Poly-Med, Inc., Anderson, South Carolina

In Vitro Degradation Property of Two Fully-Absorbable Poly(lactide-co-glycolide) MeshesM. Deng, Johnson & Johnson Global Surgey Group, Somerville, NJM. Deng, Johnson & Johnson, Somerville, New JerseyD. Burkley, Johnson & Johnson, Somerville, New JerseyM. Xu, Johnson & Johnson, Somerville, New JerseyS. Savidge, Johnson & Johnson, Somerville, New JerseyI. Koyfman, Johnson & Johnson, Somerville, New JerseyC. Yang, Johnson & Johnson, Somerville, New JerseyY. Li, Johnson & Johnson, Somerville, New Jersey

Poster

Advances in Ophthalmic Biomaterials and Ocular Drug-Delivery1

β-Cyclodextrin-poly(β-amino ester) Nanoparticles as Drug Carriers to TreatRetinoblastomaT. L. Lowe, University of Tennessee Health Science Center, Memphis, TNL. Wu, University of Tennessee Health Science Center, memphis, TennesseeD. R. Janagam, University of Tennessee Health Science Center, memphis, TennesseeS. Jiang, University of Tennessee Health Science Center, memphis, Tennessee

Advances in Ophthalmic Biomaterials and Ocular Drug-Delivery2

Development of a Biomimetic Vitreous SubstituteN. Ravi, V.A. Medical Center, St. Louis, MOP. D. Hamilton, VA Medical Center, St. Louis, Missouri

Advances in Polymeric Nano-/Microparticle Formulation Techniques

Encapsulation of Cells by Microfluidics and Diffusive Michael-type Gelation of SyntheticMicrogelsD. M. Headen, Georgia Institute of Technology, Atlanta, GAG. Aubry, Georgia Institute of Technology, Atlanta, GeorgiaH. Lu, Georgia Institute of Technology, Atlanta, GeorgiaA. Garcia, Georgia Institute of Technology, Atlanta, Georgia

Polyion Complex-Coated Polymeric Micelles with Highly Stability as Cell-Specific Drug

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Delivery VehiclesY. Ohya, Kansai University, Suita, Osaka, JapanY. Morimoto, Kansai University, Suita, JapanA. Takahashi, Kansai University, Suita, JapanA. Kuzuya, Kansai University, Suita, JapanA. Maruyama, Kyushu University, Fukuoka, Japan

Advances in Tissue Engineering Scaffolding

Core-Shell Hollow Microfibers by Triaxial ElectrospinningA. Khalf, Oklahoma State University, Stillwater, OKK. Singarapu, Oklahoma State Univeristy, Stillwater, OklahomaS. Madihally, Oklahoma State Univeristy, Stillwater, Oklahoma

Altering Fibrin Matrix Properties with pNIPAm Microgels for Wound Healing ApplicationsA. M. Douglas, Georgia Institute of Technology, Atlanta, GA

Composites of Elastin-Like Polypeptide, Collagen, and Bioglass: Mechanical and Cell CulturePropertiesA. Janorkar, University of Mississippi Medical Center, Jackson, MST. Wheeler, University of Mississippi Medical Center, Jackson, MississippiN. Sbravati, University of Mississippi Medical Center, Jackson, Mississippi

Fabrication of Continuous PDMSstar-PEG Gradients for Osteochondral RegenerationB. M. Bailey, Texas A&M University, College Station, TXL. N. Nail, Texas A&M University, College Station, TexasM. A. Grunlan, Texas A&M University, College Station, Texas

Novel (Poly)caprolactone (PCL) Scaffold Architecture for Tendon Tissue EngineeringApplicationsB. L. Banik, The Pennsylvania State University, State College, PAJ. L. Brown, The Pennsylvania State University, University Park, Pennsylvania

Dermal substitutes using electrospun silk fibroin nanofiber spongeC. Park, Nano-Bio Regenerative Medical Institute, Hallym University, Chuncheon, Republicof Korea

Models to Predict the Resorption Rate of Bioresorbable Textile ScaffoldsC. R. Gajjar, North Carolina State University, Raleigh, NCC. Li, North Carolina State University, Raleigh, North CarolinaS. Chung, Korea Institute of Science & Technology Evaluation & Planning, Seoul, Korea, DemocraticPeople's Republic ofR. Payne, Tengion Inc., Winston-Salem, North CarolinaM. W. King, North Carolina State University, Raleigh, North Carolina

Tricomponent Fibrous Scaffolds with Dual Delivery of rhVEGF and rhBMP-2 for Bone TissueEngineeringC. Wang, The University of Hong Kong, Hong Kong SAR, Hong KongM. Wang, The University of Hong Kong, Hong Kong SAR, Hong Kong

Bone Marrow Absorption and Retention using Capillary Action via Micro-Channel StructureD. S. Oh, Columbia University, New York, NY

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F. Y. Lee, Columbia University, New York, New YorkH. Tawfeek, Columbia University, New York, New YorkP. H. Lim, Columbia University, New York, New YorkD. Ganbat, Kyung Hee University, Yongin, Republic of KoreaY. Kim, Kyung Hee University, Yongin, Republic of Korea

Bioactive Shape Memory Polymer Scaffolds for Bone Defect RepairsD. Zhang, Texas A&M University, College Station, TXO. J. George, Texas A&M University, College Station, TexasK. M. Petersen, Texas A&M University, College Station, TexasM. A. Grunlan, Texas A&M University, College Station, Texas

Devitalized Cell Derived Polymer/Extracellular Matrix Composite Scaffolds for CartilageRegenerationE. J. Levorson, Rice University, Houston, TXO. Hu, Rice University, Houston, TexasF. Kasper, Rice University, Houston, TexasA. G. Mikos, Rice University, Houston, Texas

Self-assembling injectable peptide hydrogel for biomedical applicationsH. Huang, Kansas State University, Manhattan, KSX. Sun, Kansas State University, Manhattan, Kansas

Isolation of Electrophysiological Biosignal Utilizing Silicone and Xenogeneic ExtracellularMatrixJ. V. Larson, University of Michigan, Ann Arbor, MIT. A. Kung, University of Michigan, Ann Arbor, MichiganM. G. Urbanchek, University of Michigan, Ann Arbor, MichiganP. S. Cederna, University of Michigan, Ann Arbor, MichiganN. B. Langhals, University of Michigan, Ann Arbor, Michigan

Trilayered Design in Aortic Valve Tissue Engineering: A Polymeric ApproachJ. Liao, Mississippi State University, Mississippi State, MSJ. Guan, Ohio State University, Columbus, Ohio

Differentiation of Mesenchymal Stem Cells on Polymeric Ligament Fascicle SubstituteK. L. Lee, Rensselaer Polytechnic Institute, Troy, NYG. A. Ngai, Rensselaer Polytechnic Institute, Troy, New YorkS. C. Varghese, Rensselaer Polytechnic Institute, Troy, New YorkJ. A. Cooper, Jr., Rensselaer Polytechnic Institute, Troy, New York

The effect of different sterilization techniques on material characteristics of abiodegradable nanocomposite polymer for use in tissue engineering purposes and its in-vitro and in-vivo biocompatibilityL. Yildirimer, University College London, London, United Kingdom (Great Britain)

Shape-memory Activated Change in Scaffold Fiber Alignment Directs Stem Cell MorphologyL. Tseng, Syracuse University, Syracuse Biomaterials Institute, Syracuse, NY

In Vitro Osteoblastic Differentiation on Bioactive Glass and Glass-ceramic SurfacesO. C. Alves, Ribeirao Preto Dental School, University of Sao Paulo, Ribeirao Preto (SP),Brazil, Ribeirão Preto-SP, BrazilF. S. Oliveira, Ribeirao Preto Dental School, University of Sao Paulo, Ribeirao Preto (SP), Brazil,

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Ribeirão Preto, BrazilE. D. Zanotto, Federal University of Sao Carlos, Sao Carlos (SP), Brazil, São Carlos, BrazilO. Peitl, II, Federal University of Sao Carlos, Sao Carlos (SP), Brazil, São Carlos, BrazilM. M. Beloti, Ribeirao Preto Dental School, University of Sao Paulo, Ribeirao Preto (SP), Brazil,Ribeirão Preto, BrazilA. L. Rosa, Ribeirao Preto Dental School, University of Sao Paulo, Ribeirao Preto (SP), Brazil,Ribeirão Preto, BrazilP. T. Oliveira, Ribeirao Preto Dental School, University of Sao Paulo, Ribeirao Preto (SP), Brazil,Ribeirão Preto, Brazil

Modular Biomaterial Systems for Rapid and Functional VascularizationR. T. Annamalai, Wayne State University, Detroit, MID. R. Armant, Wayne State University, Detroit, MichiganH. W. T. Matthew, Wayne State University, Detroit, Michigan

Decellularized Liver Tissue Based Hydrogel for Repair and RegenerationR. E. Coronado, University of Texas Health Science Center San Antonio / University of Texasat San Antonio, San Antonio, TX

Poly(ε-caprolactone) Shape Memory Polymer for Filling Critical-Sized DefectsR. M. Baker, Syracuse University, Syracuse, NYJ. H. Henderson, Syracuse University, Syracuse, New YorkP. T. Mather, Syracuse University, Syracuse, New York

The Development of Synthetic Polypeptide-Based Hydrogel Systems for BiomaterialsS. M. Morey, Massachusetts Institute of Technology, Medford, MAA. M. Oelker, Massachusetts Institute of Technology, Cambridge, MassachusettsL. G. Griffith, Massachusetts Institute of Technology, Cambridge, MassachusettsP. T. Hammond, Massachusetts Institute of Technology, Cambridge, Massachusetts

Hyaluronan-Based Multi-Phasic Scaffolds for Osteochondral Tissue RegenerationS. L. Fenn, University of Vermont, Burlington, VTT. Miao, University of Vermont, Burlington, VermontR. A. Oldinski, University of Vermont, Burlington, Vermont

Comparison of Elastomeric Polymers for Bladder RegenerationS. Sivaraman, Clemson university, Clemson, SCN. Amoroso, University of Pittsburgh, Pittsburgh, PennsylvaniaW. Wagner, University of pittsburgh, Pittsburgh, PennsylvaniaS. Sant, University of Pittsburgh, Pittsburgh, PennsylvaniaJ. Nagatomi, Clemson University, Clemson, South Carolina

Development and Characterization of a Novel Polycaprolactone Fumarate (PCLF) ScaffoldManufactured through a Sacrificial Molding TechniqueS. C. Chase, Mayo Clinic, Rochester, MNE. Wagner, Mayo Clinic, Rochester, MinnesotaD. Bravo, Mayo Clinic, Rochester, MinnesotaM. Dadsetan, Mayo Clinic, Rochester, MinnesotaS. Kakar, Mayo Clinic, Rochester, MinnesotaM. Yaszemski, Mayo Clinic, Rochester, Minnesota

Spatial control of drug delivery in multilayered poly(vinyl alcohol) scaffold for tissueregeneration

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T. Miao, University of Vermont, Burlington, VTT. Miao, University of Vermont, Burlington, VermontR. A. Oldinski, University of Vermont, Burlington, Vermont

Novel Scaffold Design that Adds a Third Dimension to Engineering Complex TissuesT. He, North Carolina State University, Raleigh, NCK. Sippel, ITA, RWTH Aachen University, Raleigh, North CarolinaA. O. Inman, III, North Carolina State University, Raleigh, North CarolinaN. Monteiro-Riviere, North Carolina State University, Raleigh, North CarolinaS. Lee, Wake Forest Institute of Regenerative Medicine, Winston-Salem, North CarolinaM. W. King, College of Textiles, North Carolina University & College of Textiles, Donghua University,Raleigh, North Carolina

Is Interconnected Pore Volume Equal to Pore Size? Novel Technique to Evaluate InternalPore Volume of Tissue Engineering ScaffoldsT. He, North Carolina State University, Raleigh, NCJ. Liang, North Carolina State University, Raleigh, North CarolinaS. H. Bernacki, North Carolina State University, Raleigh, North CarolinaM. W. King, North Carolina State University, Raleigh, North Carolina

Inverse Opal Scaffolds for Regenerative Medicine: Fabrication, Advantages and ApplicationsY. Zhang, Georgia Institute of Technology, Atlanta, GAK. P. Regan, Bates College, Lewiston, MaineY. Xia, Georgia Institute of Technology, Atlanta, Georgia

Grooved PLGA Films Incorporated with RGD/YIGSR Peptides for Potential Application onSkeletal Muscle Tissue EngineeringP. WANG, Swinburne University of Technology, Melbourne, Australia

Self-assembling “smart” hydrogels with bioadhesive properties for tissue engineeringapplicatiJ. Vernengo, Rowan University, Glassboro, NJC. Wiltsey, Rowan University, Glassboro, New JerseyT. Christiani, Rowan University, Glassboro, New JerseyJ. Williams, Rowan University, Glassboro, New JerseyJ. Scaramazza, Rowan University, Glassboro, New JerseyC. Van Sciver, Rowan University, Glassboro, New JerseyK. Toomer, Rowan University, Glassboro, New JerseyJ. Sheehan, Rowan University, Glassboro, New JerseyA. Branda, Rowan University, Glassboro, New JerseyJ. Kadlowec, Rowan University, Glassboro, New JerseyC. Iftode, Rowan University, Glassboro, New Jersey

Novel Biointegrative Cross-linked Degradable Polyurethane Scaffold MatrixA. Datta, Biomerix Corporation, Somerset, NJD. Grande, Feinstein Institute for Medical Research, Manhasset, New York

Construction of a Collagen-Based, Split Thickness Cornea SubstituteV. N. HASIRCI, METU, Ankara, TurkeyA. ACUN, METU, Ankara, Turkey

A three-dimensional co-culture model of the aortic valve using magnetic levitationL. R. Balaoing, Rice University, Houston, TX

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H. Tseng, Rice University, Houston, TexasB. Grigoryan, Texas A&M University, College Station, TexasR. M. Raphael, Rice University, Houston, TexasT. C. Killian, Rice University, Houston, TexasG. R. Souza, Nano3D Biosciences, Houston, TexasK. J. Grande-Allen, Rice University, Houston, Texas

Synthesis of a Novel Injectable, ROS-degradable Tissue Engineering ScaffoldJ. R. Martin, Vanderbilt University, Nashville, TN

Animal Models for Biomaterial and Medical Device Testing

Injectable Poly(N-isopropylacrylamide)-grafted HA and Chitosan Hydrogel as a Barrier forPrevention of Postoperative Abdominal Adhesion in Laparoscopic SurgeryC. Chen, Chang Gung University, Taoyuan, Taiwan, ROC, Tao-Yuan, Taiwan

Development of Pre-Clinical In Vivo Models to Assess the Efficacy of Antimicrobial Productsto Reduce Device-Related InfectionsL. K. Hansen, WuXi AppTec, Inc., St. Paul, MND. Johnson, WuXi AppTec, Inc., St. Paul, MinnesotaK. Jenkins, WuXi AppTec, Inc., St. Paul, MinnesotaC. Bauer, WuXi AppTec, Inc., St. Paul, Minnesota

Platelet activation in juvenile ovines implanted with the PediaFlow® 4th generationpediatric ventricular assist deviceV. Shankarraman, University of Pittsburgh, Pittsburgh, PAS. Olia, University of Pittsburgh, Pittsburgh, PennsylvaniaE. Kocyildirim, University of Pittsburgh, Pittsburgh, PennsylvaniaT. M. Maul, University of Pittsburgh, Pittsburgh, PennsylvaniaM. V. Kameneva, University of Pittsburgh, Pittsburgh, PennsylvaniaS. Snyder, LaunchPoint Technologies, Goleta, CaliforniaP. D. Wearden, University of Pittsburgh, Pittsburgh, PennsylvaniaH. S. Borovetz, University of Pittsburgh, Pittsburgh, PennsylvaniaW. R. Wagner, University of Pittsburgh, Pittsburgh, Pennsylvania

Evaluation of Magnesium Alloys for Use as Degradable Stents in a Rat Trachea BypassModelT. Gilbert, ACell, Columbia, MD

Anatomical Effects in the Development of a Delayed Wound Healing ModelK. A. Kentner, ACell, Inc., Columbia, MDK. Stuart, ACell, Inc., Columbia, MarylandK. Lam, Bridge PTS, San Antonia, TexasC. Koeller, Bridge PTS, San Antonia, TexasD. Ochoa, Bridge PTS, San Antonia, TexasR. Patton, Bridge PTS, San Antonio, TexasT. Laufenberg, Bridge PTS, San Antonio, TexasC. Lewis, Bridge PTS, San Antonio, TexasP. Attar, Bridge PTS, San Antonio, TexasA. D. Janis, ACell, Inc., Columbia, Maryland

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Benchtop Tissue Surrogates to Model Drug Uptake and Efficacy

The Development of Hydrogel Microwells for Perfused 3D Culture of HepatocytesJ. Shepard, Massachusetts Institute of Technology, Cambridge, MAV. Chan, University of Illinois at Urbana-Champaign, Urbana, IllinoisM. Rhoads, Massachusetts Institute of Technology, Cambridge, MassachusettsM. Raredon, Massachusetts Institute of Technology, Cambridge, MassachusettsR. Dyer, Massachusetts Institute of Technology, Cambridge, MassachusettsP. Hammond, Massachusetts Institute of Technology, Cambridge, MassachusettsR. Bashir, University of Illinois at Urbana-Champaign, Urbana, IllinoisL. Griffith, Massachusetts Institute of Technology, Cambridge, Massachusetts

Biofunctional Polymers for Gene Delivery

Hemocompatible pH-responsive polymeric nanoparticle for intravenous siRNAC. E. Nelson, Vanderbilt University, Nashville, TNJ. R. Kintzing, Vanderbilt University, Nashville, TennesseeJ. M. Shannon, Vanderbilt Univeristy, Nashville, TennesseeM. K. Gupta, Vanderbilt University, Nashville, TennesseeC. L. Duvall, Vanderbilt Univeristy, Nashville, Tennessee

Lyophilized Poly(ethylene glycol-b-(dimethylaminoethyl methacrylate-co-butylmethacrylate))-DNA Nanoparticles for Nonviral Gene TherapyE. J. Adolph, Vanderbilt University, Nashville, TNC. E. Nelson, Vanderbilt University, Nashville, TennesseeJ. M. Shannon, Vanderbilt University, Nashville, TennesseeC. L. Duvall, Vanderbilt University, Nashville, TennesseeS. A. Guelcher, Vanderbilt University, Nashville, Tennessee

Transformation of Cationic Materials into Neutral Biocompatible Systems for siRNADelivery: Property and Function CharacterizationJ. Liu, Georgia Institute of Technology, Atlanta, GAJ. Zhou, Peking University, Beijing, ChinaY. Luo, Peking University, Beijing, China

Spider Silk Gene Delivery Systems for Intracellular Cell TargetingO. Tokareva, Tufts University, Medford, MAD. Glettig, Tufts University, Medford, MassachusettsR. Abbott, Tufts University, Medford, MassachusettsD. L. Kaplan, Tufts University, Medford, Massachusetts

Aptamer-Functionalized DNA Nanostructures for Targeted Antisense Delivery in CancerP. Charoenphol, University of Massachusetts - Amherst, Amherst, MAH. Bermudez, University of Massachusetts - Amherst, Amherst, Massachusetts

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Comb-shaped Cationic Polycarbonates for Gene Delivery and Antimicrobial ApplicationsZ. Ong, Institute of Bioengineering and Nanotechnology, Singapore, SingaporeD. J. Coady, IBM Almaden Research Centre, San Jose, CaliforniaJ. L. Hedrick, IBM Almaden Research Centre, San Jose, CaliforniaY. Yang, Institute of Bioengineering and Nanotechnology, Singapore, Singapore

Bioinspired Smart Materials for Regenerative Medicine Applications

Hyaluronic Acid-Catechol Hydrogel for Liver Tissue EngineeringJ. Lee, Yonsei University, Seoul, Republic of KoreaJ. Shin, Yonsei University, Seoul, Republic of KoreaC. Lee, Yonsei University, Seoul, Republic of KoreaS. Cho, Yonsei University, Seou, Republic of Korea

Theoretical Piezoelectric Composite Model for Use in a Spinal Fusion CageL. Friis, University of Kansas, Lawrence, KSN. E. Tobaben, University of Kansas, Lawrence, KansasJ. P. Domann, University of Kansas, Lawrence, Kansas

Enzymatic Stability of Novel Biomimetic Aggrecan for Treatment of Tissue DegenerationS. Lightfoot Vidal, Drexel University, Philadelphia, PA

Enzymatic surface erosion of high-moduli polycarbonates based on natural phenolsS. D. Sommerfeld, Rutgers - The State University of New Jersey, Piscataway, NJZ. Zhang, Rutgers - The State University of New Jersey, Piscataway, New JerseyM. Costache, Rutgers - The State University of New Jersey, Piscataway, New JerseyJ. Kohn, Rutgers - The State University of New Jersey, Piscataway, New Jersey

Growth Factor Delivery Systems that Mimic Natural Extracellular Matrix and SupplyBiological Molecules in Bone Tissue EngineeringW. Swieszkowski, Sr., Warsaw University of Technology, Warsaw, Poland

Biological Responses to Surface Modification of Biomaterials

SLIPS Surface Treatment of Medical Devices that Prevents Blood Clot Formation in theAbsence of AnticoagulantsD. C. Leslie, Harvard University, Boston, MAA. Waterhouse, Harvard University, Boston, MassachusettsA. L. Watters, Harvard University, Boston, MassachusettsJ. B. Berthet, Harvard University, Boston, MassachusettsT. M. Valentin, Harvard University, Boston, MassachusettsA. Hansen, Children's Hospital Boston, Boston, MassachusettsA. Nedder, Children's Hospital Boston, Boston, MassachusettsT. Wong, Harvard University, Cambridge, MassachusettsP. Kim, Harvard University, Cambridge, MassachusettsM. Super, Harvard University, Boston, MassachusettsJ. Aizenberg, Harvard University, Cambridge, MassachusettsD. E. Ingber, Harvard University, Boston, Massachusetts

Mechanically-Stimulated Co-cultured Tissue-Specific Scaffolds for Tendon/Bone Interface

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EngineeringJ. O. Cooper, The University of Memphis, Memphis, TNM. Goodhart, The University of Memphis, Memphis, TennesseeJ. D. Bumgardner, The University of Memphis, Memphis, TennesseeW. O. Haggard, The University of Memphis, Memphis, TennesseeJ. A. Jennings, The University of Memphis, Memphis, Tennessee

In vivo Evaluation of an Endothelial Cell-Specific Biomimetic Peptide FluorosurfactantPolymer Coating for Expanded Poly(tetrafluoroethylene) Vascular GraftsJ. Bastijanic, Case Western Reserve University, Cleveland, OHL. Dudash, Case Western Reserve University, Cleveland, OhioF. Kligman, Cleveland Clinic Foundation, Cleveland, OhioM. T. Allemang, University Hospitals, Cleveland, OhioR. O. Lakin, University Hospitals, Cleveland, OhioB. A. Eslahpazir, University Hospitals, Cleveland, OhioV. S. Kashyap, University Hospitals, Cleveland, OhioK. Kottke-Marchant, Cleveland Clinic Foundation, Cleveland, OhioR. Marchant, Case Western Reserve University, Cleveland, Ohio

Innovative Injury versus Non-Injury Migration AssaysK. R. Ammann, University of Arizona, Tucson, AZK. J. DeCook, University of Arizona, Tucson, ArizonaP. L. Tran, University of Arizona, Tucson, ArizonaM. J. Slepian, University of Arizona, Tucson, Arizona

In Vitro Behavior of Human Osteoblastic Cells Cultured on Titanium Surfaces Modified byOxidative NanopatterningK. F. B. Prado, Dental School of Ribeirão Preto, University of São Paulo, Ribeirão Preto,BrazilF. Variola, University of Ottawa, Ottawa, CanadaM. R. W. Ferreira, Dental School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilR. R. Fernandes, Dental School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilF. G. Azevedo, Dental School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

Improved Osteoblast Response to UV-Irradiated Superhydrophilic PMMA/TiO2NanocompositesM. Shayan, University of Pittsburgh, Pittsburgh, PA

Macrophage Interactions with Nanoporous Titanium SurfacesM. B. Ariganello, Université de Montréal, Ottawa, ON, Canada

Surface Chemistry Modulation of Valvular Interstitial CellsM. N. Rush, University of New Mexico, Albuquerque, NME. Esquivel, University of New Mexico, Albuquerque, New MexicoE. L. Hedberg-Dirk, University of New Mexico, Albuquerque, New Mexico

Anti-fouling Medical Coatings Prepared with Amphiphilic PEG-SilanesM. A. Grunlan, Texas A&M University, College Station, TXM. L. Hawkins, Texas A&M University, College Station, TexasM. A. Rufin, Texas A&M University, College Station, TexasJ. A. Gruetzner, Texas A&M University, College Station, Texas

The use of a library of industrial materials to determine the nature of substrate-dependent

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performance of primary adherent human cellsM. Ni, Institute of Bioengineering and Nanotechnology, Singapore, Singapore

Decreasing bacterial colonization around the Intraosseous Transcutaneous AmputationProsthesis without inducing cytotoxicity to fibroblasts using hydroxyapatite, silver andfibronectinM. Chimutengwende-Gordon, Institute of Orthopaedics and Musculoskeletal Science,University College London, London, United Kingdom (Great Britain)C. Pendegrass, Institute of Orthopaedics and Musculoskeletal Science, UCL, Stanmore, UnitedKingdom (Great Britain)G. Blunn, Institute of Orthopaedics and Musculoskeletal Science, Stanmore, United Kingdom (GreatBritain)

Octacalcium phosphate/gelatin composite: the effect of synthesis and crystal elongation onrabbit tibia bone repairO. Suzuki, Tohoku University Graduate School of Dentistry, Sendai, Japan

Osteopontin Expression by Osteogenic Cells Cultured on Nanoporous TiataniumP. Adachi, Jr., University of Sao Paulo, Ribeirao Preto, BrazilW. M. A. Maximiano, Jr., School of Dentistry of Ribeirao Preto, Ribeirao Preto, BrazilA. L. Rosa, School of Dentistry of Ribeirao Preto, Ribeirao Preto, BrazilA. Nanci, Université de Montréal, Montréal, Québec, CanadaP. T. Oliveira, School of Dentistry of Ribeirao Preto, Ribeirao Preto, Brazil

Amino Acid - Based Antifouling Poly (serine methacrylate)Q. Liu, University of Akron, Akron, OHA. Singh, University of Akron, Akron, OhioL. Liu, University of Akron, Akron, Ohio

Effect of protein adsorption on human osteoblast response to porous ferritic fibre networksR. L. Spear, University of Cambridge, Cambridge, United Kingdom (Great Britain)B. Srigengan, University of Cambridge, Cambridge, United Kingdom (Great Britain)A. E. Markaki, University of Cambridge, Cambridge, United Kingdom (Great Britain)

Interaction of Endothelial and Smooth Muscle Cells with Paclitaxel-Immobilized SelfAssembled MonolayersS. Lamichhane, The University of South Dakota, Sioux Falls, SDS. Lancaster, South Dakota Innovation Partners, Sioux Falls, South DakotaE. Thiruppathi, The University of South Dakota, Sioux Falls, South DakotaG. Mani, The University of South Dakota, Sioux Falls, South Dakota

Limits to the utilization of polydopamine coating with the example of flax fibers as asubstrateS. A. A. Michel, Maastricht University, Maastricht, NetherlandsM. L. W. Knetsch, Maastricht University, Maastricht, NetherlandsL. H. Koole, Maastricht University, Maastricht, Netherlands

Combined Treatment of a Tendon Gap with a Biomimetic Electrospun Scaffold, Stromal Cellsand GDF5R. James, University of Connecticut Health Center, Farmington, CT

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Biologically Derived Materials From Natural Resources

Basic Properties of Starfish Bone and Its Phase Transformation Reaction in Phosphate SaltSolutionA. Takeuchi, Shinshu University, Matsumoto, JapanD. Honda, Shinshu University, Matsumoto, JapanK. Ishikawa, Kyushu University, Fukuoka, Japan

Material Screening for Skeletal Muscle RegenerationB. E. Pollot, University of Texas at San Antonio, San Antonio, TXC. R. Rathbone, United States Army Institute of Surgical Research, Fort Sam Houston, TexasJ. C. Wenke, US Army Institute of Surgical Research, Fort Sam Houston, TexasT. Guda, University of Texas at San Antonio, San Antonio, Texas

Comparison of Mechanical Response of Intact Artery and Isolated Arterial ElastinB. Stephen, University of Maryland Baltimore County, Baltimore, MDL. Topoleski, University of Maryland Baltimore County, Baltimore, Maryland

Guest-Host Assembly of Shear-Thinning Hyaluronic Acid HydrogelsC. B. Rodell, University of Pennsylvania, Philadelphia, PAJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Magnetically guided alignment of bio-nanofibers into ordered structures for controllingstem cell behaviorsC. Mao, University of Oklahoma, Norman, OK

Design and Synthesis of an Adherent Artificial Pulmonary PleuraD. E. Wagner, University of Vermont, Burlington, VTR. A. Oldinski, University of Vermont, Burlington, VermontN. R. Bonenfant, University of Vermont, Burlington, VermontD. J. Weiss, University of Vermont, Burlington, Vermont

Promoting Chondrogenesis and Maintaining the Bioactivity of Proteins using a BiomimeticMaterialG. Portocarrero, New Jersey Institute of Technology, Hillside, NJA. Molina, New Jersey Institute of Technology, Newark, New JerseyG. Collins, New Jersey Institute of Technology, Newark, New JerseyT. Arinzeh, New Jersey Institute of Technology, Newark, New Jersey

Thermally stable polylactide stereocomplex conjugated by bio-based compound at bothinitiating and terminal groupsH. Ajiro, Osaka University, Suita, JapanT. H. Thi, Viet Tri University of Industry, Phu Tho, Viet NamT. Fujiwara, The University of Memphis, Memphis, TennesseeM. Akashi, Osaka University, Suita, Japan

Biomimetic apatite-coated chitosan based scaffolds for bone regenerationH. Park, University of California, Los Angeles, Los Angeles, CA

Three-Dimensional Biomolecular Architectures for Characterizing BacterialSociomicrobiologyJ. B. Shear, University of Texas at Austin, Austin, TXJ. Connell, University of Texas at Austin, Austin, Texas

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M. Fitzpatrick, University of Texas at Austin, Austin, TexasE. T. Ritschdorff, University of Texas at Austin, Austin, TexasE. C. Spivey, University of Texas at Austin, Austin, TexasM. Whiteley, University of Texas at Austin, Austin, Texas

DMSO Resistance of Hyaluronic Acid-Based Hydrophilic CoatingsJ. Rosenman, Biocoat, Inc., Horsham, PAE. Pervin, Biocoat, Inc., Horsham, PennsylvaniaJ. Simon, Biocoat, Inc., Horsham, Pennsylvania

Chitosan Source Evaluation by Two Degradation Assessment Methods for a Local DeliveryDeviceK. Smith, The University of Memphis, Memphis, TNA. Parker, The University of Memphis, Memphis, TennesseeA. Jennings, The University of Memphis, Memphis, TennesseeW. Haggard, The University of Memphis, Memphis, Tennessee

Naturally Derived Fatty Acid Biomaterials for Local Drug DeliveryK. M. Faucher, Atrium Medical Corporation, MAQUET GETINGE Group, Hudson, NHN. Artzi, MIT, Cambridge, MassachusettsT. Albergo, Atrium Medical Corporation, MAQUET GETINGE Group, Hudson, New HampshireJ. Bienkiewicz, Atrium Medical Corporation, MAQUET GETINGE Group, Hudson, New HampshireS. Conroy, Atrium Medical Corporation, MAQUET GETINGE Group, Hudson, New HampshireA. Dale, Atrium Medical Corporation, MAQUET GETINGE Group, Hudson, New HampshireI. Kozlova, Atrium Medical Corporation, MAQUET GETINGE Group, Hudson, New HampshireE. R. Edelman, MIT, Cambridge, MassachusettsP. Martakos, Atrium Medical Corporation, MAQUET GETINGE Group, Hudson, New Hampshire

Fabrication of a Bioinspired Cellulose-based Composite with Biocompatible Surface as aPotential Scaffold in Vascular Tissue EngineeringP. Pooyan, Georgia Institute of Technology, Atlanta, GAL. P. Brewster, 1) Emory University School of Medicine; 2) Georgia Institute of Technology, Atlanta,GeorgiaR. Tannenbaum, 1) University of Alabama at Birmingham; 2) Georgia Institute of Technology,Atlanta, GeorgiaH. Garmestani, Georgia Institute of Technology, Atlanta, Georgia

Fabrication of Silk/Chitosan-based Hydrogels by Gamma IrradiationP. Uttayarat, Thailand Institute of Nuclear Technology (Public Organization), Nakornnayok,Thailand

Crosslinked Hyaluronic Acid Hydrogel Networks Designed as Mechano-stimulatorsP. S. Varde, Syracuse University, Syracuse, NYJ. M. Hasenwinkel, Syracuse University, Syracuse, New York

Peptide block copolymers to improve silk biomaterial/hard-tissue interfacesR. Calabrese, Tufts University, Medford, MAG. Qin, Tufts University, Medford, MassachusettsD. L. Kaplan, Tufts University, Medford, Massachusetts

Two-layer silk tubular scaffolds for small diameter blood vessel regenerationV. Catto, Politecnico di Milano, Milano, ItalyR. Elia, Tufts University, Medford, Massachusetts

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M. Tanzi, Politecnico di Milano, Milano, ItalyG. Freddi, INNOVHUB - Stazioni Sperimentali per l'Industria - Divisione Stazione Sperimentale per laSeta, Milano, ItalyS. Farè, Politecnico di Milano, Milano, ItalyD. L. Kaplan, Tufts University, Medford, Massachusetts

A Comparative Study of Decellularized Extracellular Matrix Biomaterials from DifferentSourcesx. luo, Tongji Hospital, Huazhong University of Science and Technology,Wuhan, People'sRepublic of China, Wuhan,Hubei, China

Self-Deployable Current Source Fabricated From Edible MaterialsY. Kim, Carnegie Mellon University, Pittsburgh, PAC. J. Bettinger, Carnegie Mellon University, Pittsburgh, PennsylvaniaS. Chun, Carnegie Mellon University, Pittsburgh, PennsylvaniaJ. Whitacre, Carnegie Mellon University, Pittsburgh, Pennsylvania

Investigating the osteogenic potential of decellularized extracellular matrices derived fromdifferent tissues of originV. Z. Beachley, Johns Hopkins University, Baltimore, MDM. Gibson, Johns Hopkins University, Baltimore, MarylandJ. Elisseeff, Johns Hopkins University, Baltimore, Maryland

Solution Structure of Poly-amido-saccharidesS. E. Stidham, Boston University, Boston, MAS. L. Chin, Boston University, Boston, MassachusettsE. L. Dane, Boston University, Boston, MassachusettsM. W. Grinstaff, Boston University, Boston, Massachusetts

Biologically Inspired Biomaterials Approaches for Cancer Research

Biphasic Cell Responses on Laterally Mobile FilmsA. P. Kourouklis, Umass, Amherst, Amherst, MAR. V. Lerum, Umass, Amherst, Amherst, MassachusettsH. Bermudez, Umass, Amherst, Amherst, Massachusetts

Synergy of matrix stiffness and EGFR inhibition in apoptosis of pancreatic tumor cells in 3DC. Lin, Indiana University-Purdue University at Indianapolis, Indianapolis, INC. Ki, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana

Stem cells as a photosensitizer carrier to attack cancer cells for photodynamic therapy ofbreast cancerC. Mao, University of Oklahoma, Norman, OK

Matrix Rigidity Regulates Osteolytic Gene Expression in Oral Squamous Cell CarcinomasJ. M. Page, Vanderbilt University, Nashville, TN

Hyaluronic Acid Based Hydrogels with Tunable Properties for the Study of Breast CancerS. A. Fisher, University of Toronto, Toronto, ON, CanadaS. C. Owen, University of Toronto, Toronto, Ontario, CanadaM. S. Shoichet, University of Toronto, Toronto, Ontario, Canada

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Fibronectin and Type I Collagen Synergy in Tumor ProgressionK. Wang, Cornell University, Ithaca, NYR. Andresen-Eguiluz, Cornell University, Ithaca, New YorkB. Seo, Cornell University, Ithaca, New YorkS. Hu, Cornell University, Ithaca, New YorkC. Fischbach, Cornell University, Ithaca, New YorkD. Gourdon, Cornell University, Ithaca, New York

Biomaterial Strategies for Innervation, Nerve Repair and Integration

Multifunctional Alginate Scaffolds for Spinal Cord RepairD. Shahriari, Michigan State University, East Lansing, MID. Lynam, Michigan State University, East Lansing, MichiganK. Koffler, University of California, San Diego, La Jolla, CaliforniaC. Chan, Michigan State University, East Lansing, MichiganM. Tuszynski, University of California, San Diego, La Jolla, CaliforniaJ. Sakamoto, Michigan State University, East Lansing, Michigan

Potential Neural Interface Material Printed via Projection Micro-StereoLithography (PmSL)K. N. Cicotte, University of New Mexico Sandia National Laboratories, Albuquerque, NMS. Buerger, Sandia National Laboratories, Albuquerque, New MexicoP. P. Lin, MD Anderson Cancer Center, Houston, TexasG. Reece, MD Anderson Cancer Center, Houston, TexasE. L. Hedberg-Dirk, University of New Mexico, Albuquerque, New MexicoS. M. Dirk, Sandia National Laboratories, Albuquerque, New Mexico

Intracortical Electrodes of Different Material, Shape, Size and Tethering Induce DifferentialInflammatory Responses that Significantly Impact Chronic Electrode Function.L. Karumbaiah, Georgia Institute of Technology, Atlanta, GAT. Saxena, Georgia Institute of Technology, Atlanta, GeorgiaK. Patil, Georgia Institute of Technology, Atlanta, GeorgiaR. Patkar, Georgia Institute of Technology, Atlanta, GeorgiaM. Betancur, Georgia Institute of Technology, Atlanta, GeorgiaG. B. Stanley, Georgia Institute of Technology, Atlanta, GeorgiaR. V. Bellamkonda, Georgia Institute of Technology, Atlanta, Georgia

Controlled release of Chondroitinase ABC to the injured spinal cordM. Pakulska, University of Toronto, Toronto, ON, Canada

Decellularized Equine Sciatic Nerve Hydrogel for Peripheral Nerve RepairS. T. LoPresti, University of Pittsburgh, Pittsburgh, PA

Basement Membrane-Polycaprolactone Blend Nanofibers as a Scaffold for TissueEngineeringS. Lenz, University of Virginia, Charlottesville, VAR. Neal, University of Virginia, Charlottesville, VirginiaD. Abebayehu, University of Virginia, Charlottesville, VirginiaB. Brooks, University of Virginia, Charlottesville, VirginiaR. C. Ogle, LifeNet Institute of Regenerative Medicine, Norfolk, VirginiaE. Botchwey, Georgia Institute of Technology, Atlanta, Georgia

Microspheres for sustained delivery of NEP1-40 and chondroitinase ABC for treatment of

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spinal cord injuryT. Wilems, Washington University, St. Louis, MOD. McCreedy, Washington University, St.Louis, MissouriL. Marquardt, Washington University, St. Louis, MissouriS. E. Sakiyama-Elbert, Washington University, St. Louis, Missouri

Decellularized Equine Sciatic Nerve as a Scaffold for Peripheral Nerve RepairT. Prest, University of Pittsburgh, Pittsburgh, PA

Electrically Conductive Nerve Guidance ChannelZ. Zhang, Laval University, Quebec, QC, CanadaZ. Du, Laval University, Quebec, Québec, Canada

Photoreactive Interpenetrating Network with Tunable Stiffness as a Scaffold for NeuriteGrowthP. Khoshakhlagh, Tulane University, New orleans, LAE. L. Horn-Ranney, Tulane University, New Orleans, LouisianaM. J. Moore, Tulane University, New Orleans, Louisiana

Biomaterial Strategies for Large-Area Bone Regeneration

Effect of novel putty-like resorbable calcium alkali orthophosphate bone substitutecements designed for restoring contours in craniofacial surgery on bone formation andosteoblastic phenotype expression in vivoC. Knabe, Philipps University Marburg, Marburg, GermanyG. Berger, Federal Institute for Materials Research and Testing, Berlin, GermanyR. Gildenharr, Federal Institute for Materials Research and Testing, Berlin, GermanyF. Dombrowski, Federal Institute for Materials Research and Testing, Berlin, GermanyK. Reiter, Philipps University Marburg, Marburg, GermanyA. Houshmand, Philipps University Marburg, Marburg, GermanyM. Stiller, Philipps University Marburg, Marburg, Germany

Vascular endothelial growth factor expression in posterolateral rabbit fusion: Anevaluation of bone graft materialsF. V. Lamberti, Pioneer Surgical, Greenville, NCW. R. Walsh, University of New South Wales, Syndey, AustraliaR. A. Oliver, University of New South Wales, Sydney, AustraliaY. Yu, University of New South Wales, Sydney, AustraliaB. Schlossberg, Pioneer Surgical, Woburn, Massachusetts

Fabrication of Customized Porous Hydroxyapatite (HA) implants for Bone ReconstructionH. Jung, Department of Materials Science and Engineering, Seoul National University,Seoul, Republic of KoreaT. Jang, Department of Materials Science and Engineering, Seoul National University, Seoul,Republic of KoreaM. Kang, Department of Materials Science and Engineering, Seoul National University, Seoul,Republic of KoreaH. Kim, Department of Materials Science and Engineering, Seoul National University, Seoul, Republicof KoreaY. Koh, Dental Laboratory Science and Engineering, Korea University, Seoul, Republic of KoreaY. Estrin, Department of Materials Engineering, Monash University, Clayton, Australia

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Sustained Bone Morphogenetic Protein 2 Delivery from Densified Titanium for the BoneRegenerationH. Jung, Department of Materials Science and Engineering, Seoul National University,Seoul, Korea, Seoul, Republic of KoreaM. Kang, Department of Materials Science and Engineering, Seoul National University, Seoul, Korea,Seoul, Republic of KoreaH. Kim, Department of Materials Science and Engineering, Seoul National University, Seoul, Korea,Seoul, Republic of KoreaY. Estrin, Department of Materials Engineering, Monash University, Clayton, Australia, Clayton,Republic of Korea

Developing Polymer/Ceramic Scaffolds using a Factorial Design of Experiments andResponse-surface AnalysisJ. A. Minton, Miami University, Hamilton, OHC. Janney, Miami University, Oxford, OhioC. Focke, Miami University, Oxford, OhioP. James, Miami University, Oxford, OhioA. Yousefi, Miami University, Oxford, Ohio

Comparison of beta-tricalcium phosphate foam made using Mg stabilizer and by heattreatmentK. Ishikawa, Kyushu University, Fukuoka, JapanT. Nikaido, Kyushu University, Fukuoka, JapanK. Tsuru, Kyushu University, Fukuoka, Japan

Effect of Calcium Phosphate Coatings and Bone Morphogenetic Protein (BMP)-2 on In VivoBone Regeneration using 3-dimensional Poly (propylene fumarate) Scaffolds in RabbitCalvarial ModelM. Dadsetan, Mayo Clinic, Rochester, MN

Testing of a Bioactive, Moldable Bone Graft Substitute in an Infected, Critically-Sized DefectModelM. Brown, University of Kentucky, Lexington, KYY. Zou, University of Kentucky, Lexington, KentuckyR. Peyyala, University of Kentucky, Lexington, KentuckyT. Milbrandt, University of Kentucky, Lexington, KentuckyL. Cunningham, University of Kentucky, Lexington, KentuckyT. Dziubla, University of Kentucky, Lexington, KentuckyD. Puleo, University of Kentucky, Lexington, Kentucky

Performance of polymer + OCP composite scaffolds in the CSD rabbit calvaria modelO. Ortiz, Rutgers - The State University of New Jersey, Piscataway, NJR. Z. LeGeros, New York University, New York, New YorkJ. Kohn, Rutgers - The State University of New Jersey, Piscataway, New Jersey

Improving Transport Limitations of Tissue Engineered Bone ScaffoldsS. Tabbaa, Clemson University, Clemson, SC

The Effect of Wicking Fibers on Transport Properties of Tissue Engineered ScaffoldsS. Tabbaa, Clemson University, Clemson, SC

A Novel Approach to Engineer Vascularized Osteon-like Constructs for Cortical Bone TissueEngineering

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X. Chen, Stevens Institute of Technology, Hoboken, NJH. Wang, Stevens Institute of Technology, Hoboken, New Jersey

Surface Modified Chitosan Tissue Engineering Scaffolds for Biomimetic Periosteum onCortical Bone AllograftsR. Romero, Colorado State University, Fort Collins, COM. J. Kipper, Colorado State University, Fort Collins, Colorado

Biomaterials and Medical Product Commercialization

A novel technique for micromotion measurement of unicompartmental tibial trays fordesign comparisonG. Yildirim, Pipeline Orthopedics, Cedar Knolls, NJ

From Bench to Business: What Every Academic Should Consider Before Launching a StartupM. Van Dyke, Virginia Polytechnic Institute and State University, Blacksburg, VA

Fabrication and Tissue Anchoring performance of Nylon and Polypropylene Barbed SurgicalSuturesH. Cong, North Carolina State University, Raleigh, NCS. Roe, North Carolina State University, Raleigh, North CarolinaM. King, North Carolina State University, Raleigh, North CarolinaP. Mente, North Carolina State University, Raleigh, North CarolinaG. Ruff, 4Vilcom Circle, Chapel Hill, Raleigh, North Carolina

Reduction of Absorption Time for a Polydioxanone Homopolymer Using Polyethylene glycolD. R. Ingram, Poly-Med, Inc., Anderson, SC, SC

Biomaterials Design and Tissue Engineering via Synthetic Biology

Multiscale Organization of Nanofiber-based Structures: Nature Design, Bio-inspiredEngineering and Future DirectionsC. Zhong, Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MAT. K. Lu, Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge,Massachusetts

Biomaterials Education

Motivational Differences Between Bioengineering and Mechanical Engineering StudentsA. N. Kirn, Clemson University, Clemson, SCL. Benson, Clemson University, Clemson, South Carolina

Biomaterial Implant Design Competition for High School StudentsA. C. Parker, The University of Memphis, Memphis, TNJ. M. Goodhart, The University of Memphis, Memphis, TennesseeT. Phung, The University of Memphis, Memphis, TennesseeJ. Williams, The University of Memphis, Memphis, TennesseeJ. D. Bumgardner, The University of Memphis, Memphis, Tennessee

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Alternative Methods to Determine Extractable Monomer Content of Polydioxanone (PDO)C. Culbreath, Poly-Med, Inc., Anderson, SCJ. Olbrich, Poly-Med, Inc., Anderson, South CarolinaJ. Corbett, Poly-Med, Inc., Anderson, South Carolina

Integrating creative thinking into biomaterials education: A first year bioengineeringseminar module to teach how to design musculoskelatal bioengineering systems forregenerative purposesT. Ozdemir, The Pennsylvania State University, University Park, PA

Biomaterials for Cardiac Repair

Development of Electrospun Hyaluronic Acid Scaffolds Containing Multivalent PeptideConjugatesN. A. Rode, UC Berkeley, Oakland, CAN. C. Marks, UC Berkeley, Berkeley, CaliforniaK. E. Healy, UC Berkeley, Berkeley, California

Stem Cell Therapy in Heart Failure: Application Strategies for the CardioCel® MatrixJ. A. M. Ramshaw, CSIRO, Clayton, AustraliaA. Vashi, CSIRO, Clayton, AustraliaJ. F. White, CSIRO, Clayton, AustraliaK. M. McLean, CSIRO, Clayton, AustraliaW. M. L. Neethling, University of Western Australia, Fremantle, AustraliaJ. A. Werkmeister, CSIRO, Clayton, Australia

Biomaterials for Modulating Immune and Inflammatory Processes

Distinct Local Macrophage Phenotypes Are Associated With Divergent Tissue RemodelingOutcomes Following Implantation of Biologic ScaffoldsB. N. Brown, McGowan Institute for Regenerative Medicine, Pittsburgh, PAK. A. Kukla, Carnegie Mellon University, Pittsburgh, PennsylvaniaB. M. Sicari, McGowan Institute for Regenerative Medicine, Pittsburgh, PennsylvaniaN. J. Turner, McGowan Institute for Regenerative Medicine, Pittsburgh, PennsylvaniaL. Zhang, McGowan Institute for Regenerative Medicine, Pittsburgh, PennsylvaniaS. F. Badylak, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania

How Estrogen Receptor Signaling Modulates the Response of Human Macrophages to WearParticlesC. Li, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford,CAC. Nich, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford,CaliforniaJ. K. Antonios, Department of Orthopaedic Surgery, Stanford University School of Medicine,Stanford, CaliforniaZ. Yao, Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford,CaliforniaK. Kealoha-Steck, Department of Pathology, Stanford University School of Medicine, Stanford,CaliforniaM. Fontaine, Department of Pathology, Stanford University School of Medicine, Stanford, California

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S. B. Goodman, Department of Orthopaedic Surgery, Stanford University School of Medicine,Stanford, California

Composition of Intraperitoneal Electrospun Conduits Influence Recruited Cell Phenotypeand Matrix SynthesisC. A. Bashur, Cleveland Clinic, Cleveland, OHM. J. Eagleton, Cleveland Clinic, Cleveland, OhioA. Ramamurthi, Cleveland Clinic, Cleveland, Ohio

Bliateral regulation of human monocytes and matrix-encapsulated mesenchymalstromal/stem cells in vitro and in full-thickness cutaneous woundsD. A. Cantu, University of Wisconsin-Madison, Madison, WI

Chitosan Particles Induce Human U937 Macrophages to Release Anti-Inflammatory Factorsand Mesenchymal Stem Cell Chemokines Through Pathways Involving STAT-1D. Fong, École Polytechnique de Montréal, Montréal, QC, CanadaM. B. Ariganello, École Polytechnique de Montréal, Montréal, Québec, CanadaJ. Girard-Lauzière, École Polytechnique de Montréal, Montréal, Québec, CanadaC. D. Hoemann, École Polytechnique de Montréal, Montréal, Québec, Canada

Modulation of in vitro nitric oxide production in murine macrophages by immobilized andsoluble glycosaminoglycansG. Tan, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, JapanY. Tabata, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

Development of Controlled Drug-Releasing Constructs to Mediate Inflammation in an IsletTransplant SiteJ. D. Weaver, University of Miami, Miami, FLY. Song, University of Miami, Miami, FloridaA. Pileggi, University of Miami, Miami, FloridaP. Buchwald, University of Miami, Miami, FloridaC. L. Stabler, University of Miami, Miami, Florida

Time Course of Macrophage Polarization in Response to Wear Particles in vitroJ. K. Antonios, Stanford University School of Medicine, Stanford, CAC. Li, Stanford University School of Medicine, Stanford, CaliforniaZ. Yao, Stanford University School of Medicine, Stanford, CaliforniaA. J. Rao, Stanford University School of Medicine, Stanford, CaliforniaS. B. Goodman, Stanford University School of Medicine, Stanford, California

Vascularization for Bone Tissue Engineering through Modulation of Macrophage BehaviorK. L. Spiller, Columbia University, New York, NYR. Anfang, Columbia University, New York, New YorkJ. Ng, Columbia University, New York, New YorkK. Nakazawa, Columbia University, New York, New YorkG. Vunjak-Novakovic, Columbia University, New York, New York

Polyanhydride particle vaccine platform enhances antigen-specific cytotoxic T cellresponsesK. Ross, Iowa State University, Ames, IAL. Huntimer, Iowa State University, Ames, IowaR. Darling, Iowa State University, Ames, IowaA. Ramer-Tait, Iowa State University, Amesq, Iowa

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B. Narasimhan, Iowa State University, Ames, IowaM. Wannemuehler, Iowa State University, Ames, Iowa

Deposition and Persistence of Polyanhydride Nanoparticle Vaccines upon IntranasalAdministrationK. Ross, Iowa State University, Ames, IAS. Haughney, Iowa State University, Ames, IowaT. Brenza, Iowa State University, Ames, IowaL. Huntimer, Iowa State University, Ames, IowaP. Boggiatto, Iowa State University, Ames, IowaM. Wannemuehler, Iowa State University, Ames, IowaB. Narasimhan, Iowa State University, Ames, Iowa

Humoral responses elicited by polyanhydride nanoparticle formulations are facilitated byenhanced CD4+ T cell helper cellsK. Ross, Iowa State University, Ames, IAL. Huntimer, Iowa State University, Ames, IowaR. Darling, Iowa State University, Ames, IowaA. Ramer-Tait, Iowa State University, Ames, IowaB. Narasimhan, Iowa State University, Ames, IowaM. Wannemuehler, Iowa State University, Ames, Iowa

Polyanhydride Nanoparticle-based Influenza Vaccine Elicits Viral Neutralizing Titers andEnhances Cell-Mediated ImmunityK. Ross, Iowa State University, Ames, IAL. Huntimer, Iowa State University, Ames, IowaW. Wu, Iowa State University, Ames, IowaS. Carpenter, Iowa State University, Ames, IowaB. Narasimhan, Iowa State University, Ames, IowaM. Wannemuehler, Iowa State University, Ames, Iowa

Enhancing Mechanical Properties of Fibrin Matrices for Wound Healing Applications throughOptimized B-knob EngagementK. C. Clause, Georgia Institute of Technology, Atlanta, GA

Investigation of interaction between the dynamic polymer surfaces and collagen moleculesK. Nam, Tokyo Medical and Dental University, Tokyo, JapanJ. Seo, Tokyo Medical and Dental University, Tokyo, JapanT. Kimura, Tokyo Medical and Dental University, Tokyo, JapanN. Yui, Tokyo Medical and Dental University, Tokyo, JapanA. Kishida, Tokyo Medical and Dental University, Tokyo, Japan

Specific cytokines released by monocytes cultured on a degradable polyurethane (D-PHI)influence VSMC responseK. Battiston, University of Toronto, Toronto, ON, CanadaB. Ouyang, University of Toronto, Toronto, Ontario, CanadaR. Labow, University of Ottawa Heart Institute, Ottawa, Ontario, CanadaC. Simmons, University of Toronto, Toronto, Ontario, CanadaJ. Santerre, University of Toronto, Toronto, Ontario, Canada

Cell-Specific ECM Down-Regulates the Inflammatory Response to Nervous System ImplantsM. B. Christensen, University of Utah, Salt Lake City, UTJ. L. Skousen, University of Utah, Salt Lake City, Utah

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N. Khan, University of Utah, Salt Lake City, UtahP. A. Tresco, University of Utah, Salt Lake City, Utah

Microstructured Immunoregulatory Scaffolds for Controlling Host-Biomaterial InteractionsN. Washburn, Carnegie Mellon University, Pittsburgh, PAM. Ramadan, Carnegie Mellon University, Pittsburgh, PennsylvaniaT. Hinton, Carnegie Mellon University, Pittsburgh, PennsylvaniaA. Feinberg, Carnegie Mellon University, Pittsburgh, Pennsylvania

Polyanhydride nanoparticle vaccine platform delays tumor growth in an antigen specificmodelR. Darling, Iowa State University, Ames, IA

Ultra Strong, Thermoresponsive Double-Network HydrogelsR. Fei, Texas A&M University, Bryan, TXM. A. Grunlan, Texas A&M University, College Station, Texas

Controlled Nitric Oxide Releasing Dendronized Poly(vinyl chloride) for ImprovingBiocompatibility of Implantable DevicesS. P. Hopkins, Michigan Technological University, Houghton, MI

Novel h9e Peptide Sequence for Medical UsesT. L. Carter, Kansas State University, Manhattan, KS

Modulation of Host Response by Anti-inflammatory Drugs to Improve the Efficacy ofImmuno-isolated Islets in Diabetes TherapyT. T. Dang, Massachusetts Institute of Technology, Cambridge, MAA. V. Thai, Massachusetts Institute of Technology, Cambridge, MassachusettsJ. Cohen, Joslin Diabetes Center, Boston, MassachusettsJ. E. Slosberg, Massachusetts Institute of Technology, Cambridge, MassachusettsK. Siniakowicz, Joslin Diabetes Center, Boston, MassachusettsJ. C. Doloff, Massachusetts Institute of Technology, Cambridge, MassachusettsM. Ma, Massachusetts Institute of Technology, Cambridge, MassachusettsJ. Hollister-Lock, Joslin Diabetes Center, Cambridge, MassachusettsK. Tang, Massachusetts Institute of Technology, Cambridge, MassachusettsZ. Gu, Massachusetts Institute of Technology, Cambridge, MassachusettsH. Cheng, Massachusetts Institute of Technology, Cambridge, MassachusettsG. C. Weir, Joslin Diabetes Center, Boston, MassachusettsR. Langer, Massachusetts Institute of Technology, Cambridge, MassachusettsD. G. Anderson, Massachusetts Institute of Technology, Cambridge, Massachusetts

Magnetic Resonance Imaging Tracking of Dendritic Cells Homing to the Draining LymphNodes in MiceY. Xu, Sichuan University, Chengdu, ChinaD. Wang, Sichuan University, Chengdu, ChinaY. Liu, Sichuan University, Chengdu, ChinaC. Xia, West China Hospital, Sichun University, Chengdu, ChinaQ. Gong, West China Hospital, Sichuan University, Chengdu, ChinaB. Song, West China Hospital, Sichuan University, Chengdu, ChinaC. Wu, Sichuan University, Chengdu, ChinaG. Lin, Sichuan University, Chengdu, ChinaD. Li, Sichuan University, Chengdu, ChinaH. Ai, Sichuan University, Chengdu, China

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Encapsulation of antigen in chitosan particles enhances activation and antigen specificresponse by antigen presenting cellsB. Koppolu, University of Arkansas, Fayetteville, ARD. A. Zaharoff, University of Arkansas, Fayetteville, Arkansas

Transplantable Matrix Permits T Cell and Dendritic-Fusion Cell InteractionK. M. Charoen, Boston University, Boston, MAT. Konry, Shriners Childrens Hospitals, Boston, MassachusettsS. Cohen, Ben Gurion University, Negev, IsraelD. Avigan, Beth Israel/Deaconess Medical Center, Boston, MassachusettsM. Yarmush, Shriners Hospitals for Children, Boston, MassachusettsM. W. Grinstaff, Boston University, Boston, Massachusetts

Biomaterials for Modulating Immune and Inflammatory Processes2

Thermally stable self-adjuvanting vaccines via self-assembling peptidesT. Sun, University of Chicago, Chicago, IL

Biomaterials for Triggered Delivery to the Cytosol

Polycationic Hydrogel Nanoparticles for siRNA DeliveryD. C. Forbes, The University of Texas at Austin, Austin, TXD. C. Forbes, The University of Texas at Austin, Austin, TexasH. Frizzell, The University of Texas at Austin, Austin, TexasB. Carrillo-Conde, The University of Texas at Austin, Austin, TexasN. A. Peppas, The University of Texas at Austin, Austin, Texas

Redox Responsive Polymeric Nanocapsules for Protein DeliveryM. Zhao, University of California, Los Angeles, Los Angeles, CAY. Tang, University of California Los Angeles, Los Angeles, California

Ultrasonically Activated Delivery to the Cytosol using Acoustic Droplet VaporizationW. G. Pitt, Brigham Young University, Provo, UTJ. R. Lattin, Brigham Young University, Provo, UtahM. J. McRae, Brigham Young University, Provo, UtahK. Moake, Brigham Young University, Provo, Utah

Biomaterials in Medical Device Recycling and Reprocessing

Toward a heat-curling polymeric needle designed for safe disposalP. Yang, Syracuse University, Syracuse, NYP. T. Mather, Syracuse University, Syracuse, New York

Study on the Antimicrobial Properties of a High Copper Content Zr-based Bulk MetallicGlassW. He, The University of Tennessee, Knoxville, TNL. Huang, The University of Tennessee, Knoxville, TennesseeE. Fozo, The University of Tennessee, Knoxville, Tennessee

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Biomaterials in the Fourth Dimension – Controlling Temporal Properties

Fabrication of a Light-Emitting Shape Memory Polymeric WebA. H. Torbati, Syracuse University, Jamesville, NY

Controlled Guidance of Spinal Motor Axons through Synthetic Click HydrogelsD. D. McKinnon, University of Colorado at Boulder, Boulder, CO

Characterization of Dynamic Shape-Memory (Meth)Acrylate Networks for TissueEngineering ApplicationsE. Hewett, Georgia Institute of Technology, Atlanta, GAK. Smith, MedShape Solutions, Inc., Atlanta, GeorgiaK. Gall, Georgia Institute of Technology, Atlanta, GeorgiaZ. Schwartz, Georgia Institute of Technology, Atlanta, GeorgiaB. D. Boyan, Georgia Institute of Technology, Atlanta, Georgia

Smart Supramolecular Hydrogels encapsulated Bioengineered Stem Cells for CancerTherapyJ. Yeom, POSTECH, Pohang, Republic of KoreaS. Kim, POSTECH, Pohang, Republic of KoreaH. Jung, POSTECH, Pohang, Republic of KoreaH. Namgung, POSTECH, Pohang, Republic of KoreaJ. Yang, POSTECH, Pohang, Republic of KoreaK. Kim, POSTECH, Pohang, Republic of KoreaY. Sung, POSTECH, Pohang, Republic of KoreaS. Hahn, POSTECH, Pohang, Republic of Korea

Signal-processing BiomaterialsK. Jakobus, University of Freiburg, Freiburg, GermanyW. Weber, University of Freiburg, Freiburg, Germany

Gellan gum-based Spongy-like Hydrogels depict improved Cellular PerformanceL. P. da Silva, University of Minho (Portugal), Guimarães, PortugalM. T. Cerqueira, University of Minho, Guimarães, PortugalR. A. Sousa, University of Minho, Guimarães, PortugalA. P. Marques, University of Minho, Guimarães, PortugalV. M. Correlo, University of Minho, Guimarães, PortugalR. L. Reis, University of Minho, Guimarães, Portugal

Smart Nanofiber Webs for “On-off” Release of Cells and DrugsM. Ebara, National Institute for Materials Science, Tsukuba, JapanT. Aoyagi, National Institute for Materials Science, Tsukuba, Japan

A Novel Platform for On Demand Delivery of Multiple ProteinsN. Mokarram, Georgia Institute of Technology and Emory University, Atlanta, GAA. Merchant, Georgia Institute of Technology and Emory University, Atlanta, GeorgiaR. Bellamkonda, Georgia Institute of Technology and Emory University, Atlanta, Georgia

Dynamic Photo-Tunable Gels to Modulate Matrix StiffnessR. S. Stowers, The University of Texas at Austin, Austin, TX

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C. L. Davis, The University of Texas at Austin, Austin, TexasB. Han, The University of Texas at Austin, Austin, TexasL. J. Suggs, The University of Texas at Austin, Austin, Texas

Shape-memory Surfaces facilitate Time-dependent Observation of Cell FunctionsK. Uto, National Institute for Materials Science (NIMS), Tsukuba, JapanM. Ebara, National Institute for Materials Science (NIMS), Tsukuba, JapanT. Aoyagi, National Institute for Materials Science (NIMS), Tsukuba, Japan

Biomaterials to Decode Cell-Cell Signaling

Hydrogel-based Platforms for Co-Culture and On-Demand Cell Retrieval of HumanMesenchymal Stem CellsT. E. Rinker, Georgia Institute of Technology and Emory University, Atlanta, GAT. M. Hammoudi, Georgia Institute of Technology and Emory University, Atlanta, GeorgiaH. Lu, Georgia Institute of Technology, Atlanta, GeorgiaJ. S. Temenoff, Georgia Institute of Technology and Emory University, Atlanta, Georgia

Biomimetic Surfaces: From Multi-scale Fabrication Methods to Diagnostic, Therapeuticand Clinical Applications

Vascularized Biomaterials for Rapid Soft-Stiff Transitions in Medical DevicesA. Balasubramanian, Carnegie Mellon University, Pittsburgh, PAC. Bettinger, Carnegie Mellon University, Pittsburgh, Pennsylvania

Reinforcement of Calcium Phosphate Cement Using Silk Fibroin (SF) and Self-assembledSF-Hydroxyapatite ComplexB. Li, Soochow University, Suzhou, Jiangsu Province, China

Clickable PEG nanogel coatings compared to PEG/BSA nanogels: synergy between PEG andBSA contributes to ultralow protein adsorption as assessed by single molecule fluorescenceD. L. Elbert, Washington University in St. Louis, St. Louis, MOC. D. Donahoe, Washington University in St. Louis, St. Louis, Missouri

Mucin Layers as Biomimetic Coating for Polymeric BiomaterialsS. Lee, Technical University of Denmark, Kgs. Lyngby, Denmark

Cardiovascular Biomaterials

Design, Preparation and in vitro Assay of a Novel Endothelial Progenitor Cell CapturingVascular ProsthesisB. Li, Laval University, Quebec City, QC, CanadaZ. Zhang, Laval University, Quebec, Québec, CanadaX. Xie, Sichuan University, Chengdu, ChinaY. Zhong, Sichuan University, Chengdu, ChinaR. Guidoin, Laval University, Quebec, Québec, CanadaY. Douville, Laval University, Québec, Québec, Canada

pH neutralization and inflammation prevention by RA and PLLA-grafted magnesium

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hydroxide nanoparticlesD. Han, Korea Institute of Science and technology, Seoul, Republic of Korea

Improvement of Interfacial Adhesion by ATRP and Stereocomplex for Drug-Eluting StentsD. Han, Korea Institute of Science and Technology, Seoul, Republic of Korea

Optimization and characterization of a new injectable radiopaque chitosan-basedembolizing hydrogel for endovascular therapiesF. Zehtabi, École de technologie supérieure, Montreal, QC, Canada

Characterization and Optimization of Nanoliposomes to Deliver 17β-EstradiolK. Bowey, McGill University, Montreal, QC, CanadaI. Cloutier, Montreal Heart Institute, Montreal, Québec, CanadaJ. Tanguay, Montreal Heart Institute, Montreal, Québec, CanadaM. Tabrizian, McGill University, Montreal, Québec, Canada

Superior in vivo biocompatibility of a hydrophilic polymer coated prosthetic vascular graftM. L. W. Knetsch, Maastricht University, Maastricht, Netherlands

Hyaluronic Acid Enhancement of Polyethylene for Cardiovascular ApplicationsN. Lewis, Colorado State University, Fort Collins, CO

Functionalization of Nonwoven Poly(Ethylene Terephthalate) Structures Designed asCompliant Small-Diameter Vascular GraftsS. Noel, Ecole Polytechnique de Montreal, Montréal, QC, CanadaB. Liberelle, Ecole Polytechnique de Montréal, Montréal, Québec, CanadaA. Yogi, National Research Council Canada, Ottawa, Ontario, CanadaM. J. Moreno, National Research Council Canada, Ottawa, Ontario, CanadaM. N. Bureau, National Research Council Canada, Boucherville, Québec, CanadaL. Robitaille, National Research Council Canada, Boucherville, Québec, CanadaG. De Crescenzo, Ecole Polytechnique de Montréal, Montréal, Québec, Canada

Functional macromolecules for simple surface modification of a biodegradable magnesiumalloy to reduce thrombogenicity and improve corrosion resistanceS. Ye, University of Pittsburgh, Pittsburgh, PAV. Shankarraman, University of Pittsburgh, Pittsburgh, PennsylvaniaY. Jang, North Carolina A&T State University, Greensboro, North CarolinaH. Sakaguchi, Toray Co LtD, Pittsburgh, PennsylvaniaY. Yun, North Carolina A&T State University, Greensboro, North CarolinaW. R. Wagner, University of Pittsburgh, Pittsburgh, Pennsylvania

Impact of Age on Bovine Pericardial Composition and MechanicsT. J. Tod, Edwards Lifesciences, Irvine, CAJ. R. Yamada, Edwards Lifesciences, Irvine, CaliforniaJ. A. Benton, Edwards Lifesciences, Irvine, California

Fabrication and Mechanical Evaluation of Bicomponent PET/Silk Small Diameter ArterialProsthesesX. Yang, Key Lab of Textile Science and Technology, College of Textiles, DonghuaUniversity, Shanghai, 201620, ChinaCollege of Textiles, North Carolina State University,Raleigh 27695, USA, Raleigh, NCL. Wang, Key Lab of Textile Science and Technology, College of Textiles, Donghua University,Shanghai, 201620, China, Shanghai, China

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M. W. King, Key Lab of Textile Science and Technology, College of Textiles, Donghua University,Shanghai, 201620, China, Raleigh, North CarolinaG. Guan, Key Lab of Textile Science and Technology, College of Textiles, Donghua University,Shanghai, 201620, China, Shanghai, ChinaY. Guan, Key Lab of Textile Science and Technology, College of Textiles, Donghua University,Shanghai, 201620, China, Shanghai, China

Synthesis of Polycarbonate Urethanes with Functional Poly(ethylene glycol) Side ChainsIntended for BioconjugationX. Xie, Sichuan University, Chengdu, ChinaQ. Fu, Sichuan University, Chengdu, ChinaY. Zhong, Sichuan University, Chengdu, ChinaZ. Zhang, Université Laval, Quebec City, Québec, CanadaY. Xu, Sichuan University, Chengdu, China

Development of a Shape Memory Patch for Minimally Invasive Repair of Vascular RuptureT. Boire, Vanderbilt University, Nashville, TN

Cardiac Lead Retrieval Analysis: Insulation Degradation Hinders Long Term PerformanceM. Tohfafarosh, Drexel University, Philadelphia, PAA. Sevit, Drexel University, Philadelphia, PennsylvaniaJ. Patel, Exponent Inc., Phialdelphia, PennsylvaniaA. Greenspon, Thomas Jefferson University Hospital, Philadelphia, PennsylvaniaJ. M. Prutkin, University of Washington, Seattle, WashingtonS. Kurtz, Drexel University, Philadelphia, Pennsylvania

Ceramics and Composites in Bone Tissue Engineering and Drug Delivery

Bilayered Calcium Sulfate Space-Making Composites with Multiple Drug DeliveryCapabilitiesB. R. Orellana, University of Kentucky, Lexington, KYM. V. Thomas, University of Kentucky, Lexington, KentuckyJ. Z. Hilt, University of Kentucky, Lexington, KentuckyD. Puleo, University of Kentucky, Lexington, Kentucky

Fabrication of Customized Porous Hydroxyapatite (HA) implants for OsteotomyH. Jung, Department of Materials Science and Engineering, Seoul National University,Seoul, Republic of KoreaT. Jang, Department of Materials Science and Engineering, Seoul National University, Department ofMaterials Science and Engineering, Seoul National University, Republic of KoreaM. Kang, Department of Materials Science and Engineering, Seoul National University, Departmentof Materials Science and Engineering, Seoul National University, Republic of KoreaS. Kim, Seoul National Univ., seoul, Republic of KoreaH. Kim, Department of Materials Science and Engineering, Seoul National University, Department ofMaterials Science and Engineering, Seoul National University, Republic of KoreaY. Koh, Department of Materials Science and Engineering, Seoul National University, bDepartment ofDental Laboratory Science and Engineering, Korea University, Republic of KoreaY. Estrin, Department of Materials Engineering, Monash University, Clayton, Australia, cDepartmentof Materials Engineering, Monash University, Clayton, Australia, Republic of Korea

Cell Growth on a Gradient Calcium Polyphosphate Scaffold in a Perfusion BioreactorL. Chen, Wayne State University, Detroit, MI

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Injectable pectin- hydroxyapatite biocomposites for minimally-invasive bone surgeryM. Tanzi, Politecnico di Milano, Milano, Italy

Synthesis and Characterization of Amorphous Magnesium Phosphate: A Novel Bone CementPrecursorN. Ostrowski, University of Pittsburgh, Pittsburgh, PAB. Lee, University of Pittsburgh, Pittsburgh, PennsylvaniaN. Enick, University of Pittsburgh, Pittsburgh, PennsylvaniaA. Roy, University of Pittsburgh, Pittsburgh, PennsylvaniaP. N. Kumta, University of Pittsburgh, Pittsburgh, Pennsylvania

Comparative Properties of Gelatin/Synthetic Bone Mineral Composite and Bovine BoneR. Z. LeGeros, New York University, New York, NYS. Saraswat, New York University, New York, New YorkP. Khanna, New York University, New York, New YorkD. Mijares, New York University, New York, New YorkJ. Dai, New York University, New York, New York

Effect of silica doping on microstructral and biological properties of brushite cementsS. Bose, Washington State University, Pullman, WAS. Vahabzadeh, Washington State University, Pullman, WashingtonM. Roy, Washington state university, Pull, WashingtonA. Bandyopadhyay, Washington state university, Pullman, Washington

A Biomimetic Collagen-apatite Scaffold with Unique Multi-level Lamellar Structure for BoneTissue EngineeringZ. Xia, University of Connecticut, Coventry, CTM. Wei, University of Connecticut, Storrs, Connecticut

Dental / Craniofacial Materials

Antimicrobial and Mechanical Properties of Bioactive Glass Reinforced Dental CompositesD. Khvostenko, Oregon State University, Corvallis, ORJ. Kruzic, Oregon State University, Corvallis, OregonJ. Ferracane, Oregon Health and Science University, Portland, OregonJ. Mitchell, Oregon Health and Science University, Portland, Oregon

Development of mandibular reconstruction device made of titanium fiber scaffoldM. Hirota, Yokohama City University Graduate School of Medicine, Yokohama, Japan

Effect of Seeding Density on Human Dental Pulp Cell Response in Polyethylene Glycol-Fibrinogen HydrogelS. Prateepchinda, Columbia University, New York, NYH. H. Lu, Columbia University, New York, New YorkG. B. Hasselgren, Columbia University, New York, New YorkD. Seliktar, Technion – Israel Institute of Technology, Haifa, Israel

Antibiotic-loaded Porous Poly(methyl methacrylate) for Space Maintenance and Local DrugDeliveryS. R. Shah, Rice University, Houston, TXS. Shah, Rice University, Houston, Texas

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N. Raindel, Rice University, Houston, TexasA. Henslee, Rice University, Houston, TexasP. Spicer, Rice University, Houston, TexasF. Kasper, Rice University, Houston, TexasA. G. Mikos, Rice University, Houston, Texas

Three-Dimensionally Printed b-Tri-Calcium Phosphate/Hydroxyapatite-Bone MorphogenicProtein Scaffolds for Long Bone RegenerationN. M. Tovar, New York University College of Dentistry, New York, NYM. Sobieraj, Hospital for Joint Diseases, New York University Langone Medical Center, New York,New YorkL. Witek, Oklahoma State University, Stillwater, OklahomaJ. Smay, Oklahoma State University, Stillwater, OklahomaP. G. Coelho, New York University College of Dentistry, New York, New York

Developing the Next Generation of Cardiovascular Devices - From Concept toImplantation (An Industry Perspective)

Factors Affecting Distal Tip Stiffness of Pacemaker and Defibrillator LeadsD. Walsh, U.S. Food and Drug Administration, Silver Spring, MDB. Stephen, U.S. Food and Drug Administration, Silver Spring, MarylandL. Topoleski, University of Maryland Baltimore County, Baltimore, MarylandO. Vesnovsky, U.S. Food and Drug Administration, Silver Spring, MarylandN. Duraiswamy, U.S. Food and Drug Administration, Silver Spring, MD, Maryland

Delivery of Vitamin-C (L-Ascorbic Acid) from Coronary Stent Material SurfacesE. Thiruppathi, The University of South Dakota, Sioux Falls, SDS. Kakade, The university of South Dakota, Sioux Falls, South DakotaG. Mani, The university of South Dakota, Sioux Falls, South Dakota

A Nanofibrous Bioactive Vascular Graft for Small Vessel ReconstructionM. D. Phaneuf, BioSurfaces, Inc., Ashland, MAS. G. Pathan, BioSurfaces, Inc., Ashland, MassachusettsS. M. Ali, BioSurfaces, Inc., Ashland, MassachusettsM. J. Bide, University of Rhode Island, Kingston, Rhode IslandD. W. Nelson, BioSurfaces, Inc., Ashland, MassachusettsJ. R. Araya, Northeastern University, Boston, MassachusettsT. E. Phaneuf, BioSurfaces, Inc., Ashland, MassachusettsT. M. Phaneuf, BioSurfaces, Inc., Ashland, MassachusettsF. W. LoGerfo, Beth Israel Deaconess Medical Center, Boston, MassachusettsM. A. Contreras, Beth Israel Deacones Medical, Boston, Massachusetts

A Novel Nitric Oxide-eluting Nanocomposite Polymer for Cardiovascular ApplicationsN. Naghavi, University College London (UCL), London, United Kingdom (Great Britain)

Evaluation of Various Materials for Tip Penetration of Pacemaker and Defibrillator LeadsD. Walsh, U.S. Food and Drug Administration, Silver Spring, MDB. Stephen, U.S. Food and Drug Administration, Silver Spring, MarylandN. Duraiswamy, U.S. Food and Drug Administration, Silver Spring, MarylandO. Vesnovsky, U.S. Food and Drug Administration, Silver Spring, MarylandL. Topoleski, University of Maryland, Baltimore County, Baltimore, Maryland

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Development, Analysis, and Design of Heart Valve Biomaterials - The State of The Art

Cell Injection Initiates the Recellularization Process in Decellularized Porcine Aortic ValveScaffoldsD. B. Spoon, Mayo Clinic, Rochester, MNB. J. Tefft, Mayo Clinic, Rochester, MinnesotaK. Coffman, Mayo Clinic, Rochester, MinnesotaS. Pan, Mayo Clinic, Rochester, MinnesotaD. Taylor, Texas Heart Institute, Houston, TexasA. Lerman, Mayo Clinic, Rochester, MinnesotaR. D. Simari, Mayo Clinic, Rochester, Minnesota

Textile Heart Valve Prosthesis: Early In Vitro Fatigue PerformancesF. HEIM, Laboratoire de Physique et Mecanique Textiles, MULHOUSE, France

Valve Epithelial-to-Mesenchymal Transition is Enhanced on Composite Collagen-HyaluronicAcid HydrogelsM. Sewell-Loftin, Vanderbilt University, Nashville, TND. DeLaughter, Vanderbilt University, nashville, TennesseeJ. Barnett, Vanderbilt, Nashville, TennesseeW. Merryman, Vanderbilt, nashville, Tennessee

A NOVEL MODEL FOR HEART VALVE BIOMATERIAL FATIGUE RESPONSEM. S. Sacks, University of Texas at Austin, Austin, TXW. Zhang, University of Texas at Austin, Austin, Texas

Fabrication of Advanced Poly(ethylene glycol) Diacrylate Hydrogels for Heart Valve TissueEngineeringX. Zhang, Rice University, Houston, TXB. Xu, Rice University, Houston, TexasH. Tseng, Rice University, Houston, TexasM. L. Cuchiara, Duke University, Durham, North CarolinaJ. L. West, Duke University, Durham, North CarolinaJ. K. Grande-Allen, Rice University, Houston, Texas

Drug Delivery

Nanoparticle-based Platform Enables Increased Intracellular Antibiotic Delivery and Killingof BrucellaB. H. Bellaire, Iowa State University, Ames, IAY. Phanse, Iowa State University, Ames, IowaP. Lueth, Iowa State University, Ames, IowaB. Narasimhan, Iowa State University, Ames, Iowa

Liposomal Delivery of FTY720 Modulates Inflammatory Response in MacrophagesC. E. Segar, Georgia Institute of Technology and Emory University, Atlanta, GAE. Botchwey, Georgia Institute of Technology and Emory University, Atlanta, Georgia

Antimicrobial Effectiveness of a Triclosan Coated Warp-Knit MeshG. Hilas, Poly-Med, Inc., Anderson, SCK. Nichter, Poly-Med, Inc., Anderson, South Carolina

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S. Peniston, Poly-Med, Inc., Anderson, South CarolinaS. Nagatomi, Poly-Med, Inc., Anderson, South Carolina

In vitro Studies of Silica Xerogels for Controlled, Sustained Gene DeliveryH. Qu, University of Pennsylvania, Philadelphia, PA

Effects of Ionic Dissolution Products of Bioceramics on the Structure and Bioactivity ofDoxorubicinH. Pacheco, University of North Carolina at Charlotte, Charlotte, NCI. Nesmelova, University of North Carolina at Charlotte, Charlotte, North CarolinaD. Dréau, UNC Charlotte, Charlotte, North CarolinaA. El-Ghannam, UNC Charlotte, Charlotte, North Carolina

Administration Methods for Injectable Systems Involving Precipitation MechanicsJ. Olbrich, Poly-Med, Inc., Anderson, SCK. Gray, Poly-Med, Inc., Anderson, South CarolinaD. Ingram, Poly-Med, Inc., Anderson, South CarolinaS. Taylor, Poly-Med, Inc., Anderson, South CarolinaJ. Corbett, Poly-Med, Inc., Anderson, South Carolina

Increased Efficacy of Doxorubicin Delivery with Phytosterol NanoassembliesK. R. Fath, Queens College - City University of New York, Flushing, NYS. H. Frayne, Fordham University, Bronx, New YorkN. Nakatsuka, Fordham University, Bronx, New YorkI. Kandinov, Queens College -- City University of New York, Flushing, New YorkB. J. Cohen, Queens College -- City University of New York, Flushing, New YorkI. A. Banerjee, Fordham University, Bronx, New York

MaSp2 based recombinant spider silk particles: processing of a new drug delivery vesiclesK. Kazmierska, Adam Micwiekicz University, Poznan, PolandE. Felcyn, Greater Poland Cancer Centre, Poznan, PolandA. Florczak, Adam Mickiewicz University, Poznan, PolandM. Nowacka, Poznan University of Technology, Poznan, PolandA. Mackiewicz, Poznan University of Medical Sciences, Poznan, PolandH. Dams-Kozlowska, Greater Poland Cancer Centre, Poznan, Poland

Smart Transdermal Vaccine Delivery Systems Using Hyaluronic Acid DerivativesK. Kim, Massachusetts General Hospital, Cambridge, MAH. Kim, Pohang University of Science and Technology, Pohang, Republic of KoreaS. Yun, Massachusetts General Hospital, Cambridge, MassachusettsS. Hahn, Pohang University of Science and Technology, Pohang, Republic of Korea

Heteromultivalent Ligand Modification to Enhance Specific Bioactivity of VascularNanomedicine PlatformsL. L. Tian, Case Western Reserve University, Cleveland, OHC. Modery, Case Western University Reserve, Cleveland, OhioG. Kaur, Case Western Reserve University, Cleveland, OhioV. Pan, Case Western Reserve University, Cleveland, OhioT. Wong, Case Western Reserve University, Cleveland, OhioM. Ravikumar, Case Western Reserve University, Cleveland, OhioA. Sen Gupta, Case Western Reserve University, Cleveland, Ohio

Surface Hybridization of Macrophages with Dendrimer via Copper-Free Click Chemistry

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L. Xu, Virginia Commonwealth University, RICHMOND, VA

Correlating Akt Signaling Molecule Activation to Cytocompatibility of PhotoinitiatorsL. Xu, Virginia Commonwealth University, RICHMOND, VA

Doped Hallyosite Nanotubes as a Drug Delivery Tool for Anti-Cancer TreatmentL. Sun, Louisiana Tech University, Ruston, LAD. Mills, Louisiana Tech University, Ruston, Louisiana

Drug delivery system by micro-encapsulation of a radio-protective inclusion complexL. A. Heinrich, Sr., marcotech oHG, Muenster, GermanyB. Pajaziti, Jr., Westphalian Wilhelms University Muenster, Muenster, GermanyR. Roziev, Sr., medbiopharm Ltd., Obninsk, Kaluga Region, Russian Federation

Effectiveness of Anti-biofilm Agents against Staphylococcus aureus biofilmsM. Brown, University of Kentucky, Lexington, KYG. Huerta, University of Kentucky, Lexington, KentuckyT. Fields, University of Kentucky, Lexington, KentuckyR. Peyyala, University of Kentucky, Lexington, KentuckyT. Milbrandt, University of Kentucky, Lexington, KentuckyT. Dziubla, University of Kentucky, Lexington, KentuckyD. Puleo, University of Kentucky, Lexington, Kentucky

Drug-Eluting MicroarraysM. R. Carstens, University of Florida, Gainesville, FLB. G. Keselowsky, University of Florida, Gainesville, Florida

Controlled Release of Antimicrobial Surrogate Can Be Imaged Over 7 Days In Vivo.M. Giers, Arizona State University, Tempe, AZ

Soybean based Absorbable Polymers for Cancer PreventionN. Srivastava, Bezwada Biomedical, LLC, Hillsborough, NJ

In Situ Forming Drug Delivery Scaffold for Treating Avascular Necrosis of the Femoral HeadP. Fisher, University of Kentucky, Lexington, KYD. A. Puleo, University of Kentucky, Lexington, KentuckyJ. Z. Hilt, University of Kentucky, Lexington, KentuckyT. A. Milbrandt, University of Kentucky, Lexington, Kentucky

Structural Analysis of Unimer Nanoparticles Composed of Hydrophobized Poly(amino acid)sand Their Potential Application as Drug CarriersP. Piyapakorn, Graduate School of Engineering, Osaka University, Japan, Osaka, JapanT. Akagi, Graduate School of Engineering, Osaka University, Osaka, JapanM. Akashi, Graduate School of Engineering, Osaka University, Osaka, Japan

Combinatorial Cationic Lipid-like Nanoparticles for Efficient Intracellular Cytotoxic ProteinDeliveryQ. Xu, Tufts University, Medford, MA

Resorbable Temperature-Responsive Hydrogels Are Biocompatible Controlled ReleaseVehiclesR. McLemore, Banner Good Samaritan Medical Center, Phoenix, AZ

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Acid-responsive micelle-forming polymers as new anticancer theraperuticsS. Park, Department of BIN Fusion Technology, Jeonju, Republic of Korea

Photo-cross-linkable chitosan-lactide hydrogels for growth factor delivery: Developmentand in vitro characterizationS. Kim, Stanford University, Palo Alto, CAY. Kang, Stanford University, Stanford, CaliforniaA. Mercado-Pagan, Stanford University, Stanford, CaliforniaY. Yang, Stanford University, Stanford, California

Analysis of Molecular Weight Growth and Degradation of a Simvastatin Polymeric ProdrugT. Asafo-Adjei, University of Kentucky, Lexington, KYD. A. Puleo, University of Kentucky, lexington, KentuckyT. D. Dziubla, University of Kentucky, Lexington, Kentucky

Modulation of microRNAs for Treatment of Glioblastoma MultiformeY. Yin, Worcester Polytechnic Institute, Worcester, MAD. Rassias, Worcester Polytechnic Institute, Worcester, MassachusettsA. Jain, Worcester Polytechnic Institute, Worcester, Massachusetts

Co-delivery of chemo drug and siRNA using layer-by-layer nanoparticles for triple negativebreast cancer treatmentZ. Deng, MIT, cambridge, MAS. Morton, MIT, cambridge, MassachusettsP. Hammond, MIT, cambridge, Massachusetts

Hyperbranched Polyester Hydrogels with Controlled Drug Release and Cell AdhesionPropertiesA. K. Gaharwar, Massachusetts Institute of Technology, Cambridge, MAH. Zhang, Brigham and Women’s Hospital, Harvard Medical School,, Cambridge, MassachusettsA. Patel, Brigham and Women’s Hospital, Harvard Medical School,, Cambridge, MassachusettsS. Mihaila, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsG. Iviglia, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsS. Mukundan, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsH. Bae, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsH. Yang, University of Science and Technology, Anhui, China, ChinaA. Khademhosseini, Brigham and Women’s Hospital, Harvard Medical School, Cambridge,Massachusetts

An injectable nanodelivery system for prolonged release of the local anesthetic lidocaineI. K. Yazdi, The Methodist Hospital Research Institute, Houston, TXS. Khaled, The Methodist Hospital Research Institute, Houston, TexasJ. Van Eps, The Methodist Hospital, Houston, TexasJ. Fernandez-Moure, The Methodist Hospital, Houston, TexasN. Taghipour, The Methodist Hospital Research Institute, Houston, TexasJ. Martinez, The Methodist Hospital Research Institute, Houston, TexasS. Haddix, The Methodist Hospital Research Institute, Houston, TexasE. Tasciotti, The Methodist Hospital Research Institute, Houston, Texas

Controlled sequential release of multi-agents from layer-by-layer films for surface deliveryapplicationsJ. Min, Massachusetts Institute of Technology, Cambridge, MA

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A Novel HA-based Micelle Material as a Potent Delivery SystemT. Teng, Industrial Technology Research Institute, Hsinchu, Taiwan

Polymer Nanoparticles for Delivery of Multiple Therapeutic Agents and their Effects onGlioma GrowthA. S. Ediriwickrema, Yale University, New Haven, CTJ. Zhou, Yale University, New Haven, ConnecticutM. Saltzman, Yale University, New Haven, Connecticut

Highly efficient siRNA delivery method by self-assembled RNA microspongesD. Han, University of Seoul, Seoul, Republic of KoreaJ. Lee, University of Seoul, Seoul, Republic of Korea

Characterization of UV-Responsive Expansile NanoparticlesA. Colby, Boston University, Boston, MA

Cisplatin-Loaded Biodegradable Nanofiber Meshes for Treating Malignant PleuralMesotheliomaJ. A. Kaplan, Boston University, Newton, MAR. Yonekura, Boston University, Boston, MassachusettsY. L. Colson, Brigham and Women's Hospital, Boston, MassachusettsM. W. Grinstaff, Boston University, Boston, Massachusetts

Sustained Release of Functional Antibiotics From a Keratin HydrogelS. Tomblyn, KeraNetics, LLC, Winston-Salem, NCH. Meng, Miami University, Oxford, OhioM. Ellenburg, KeraNetics, LLC, Winston-Salem, North CarolinaL. Burnett, KeraNetics, LLC, Winston-Salem, North CarolinaJ. Saul, Miami University, Oxford, Ohio

An Implantable Intraperitoneal Drug Delivery Device for the Treatment of AdvancedOvarian CancerH. Ye, Massachusetts Institute of Technology, Cambridge, MAL. Tanenbaum, Massachusetts Institute of Technology, Cambridge, MassachusettsM. Del Carmen, Massachusetts General Hospital, Boston, MassachusettsM. Birrer, Massachusetts General Hospital, Harvard Medical School, Boston, MassachusettsM. J. Cima, Massachusetts Institute of Technology, Cambridge, Massachusetts

Drug Delivery for Inflammatory Diseases

Delivery of acetylsalicylic acid to dendritic cells using degradable micropaticlesE. Bracho-Sanchez, University of Florida, Gainesville, FLJ. L. Lewis, Univeristy of Florida, Gainesville, FloridaB. G. Keselowsky, University of Florida, Gainesville, Florida

Anti-inflammatory biocompatible dexamethasone-loaded porous microparticles for acutelung injuryD. Jeong, Departiment of BIN Fusion Chonbuk national University ,, Jeongu, Republic ofKorea

Hyaluronic Acid-Gold Nanoparticle-Tocilizumab Complex for the Treatment of RheumatoidArthritis

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H. Lee, POSTECH, San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, Republic of KoreaM. Lee, POSTECH, San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, Republic of KoreaK. Kim, POSTECH, San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, Republic of KoreaS. Hahn, POSTECH, San 31, Hyoja-dong, Nam-gu, Pohang, Kyungbuk, Republic of Korea

Efficacy of Three Antibiotic Loaded Polymer Coatings for Bone ScrewsZ. Hartsell, University of Memphis, Memphis, TNA. Hoban, University of Memphis, Memphis, TennesseeJ. Bumgardner, University of Memphis, Memphis, TennesseeH. Courtney, Veterans Affairs Medical Center and University of Tennessee Health Science Center,Memphis, TennesseeM. Gosney, Smith & Nephew, Memphis, TennesseeW. Haggard, University of Memphis, Memphis, Tennessee

Antimicrobial and Bioactive Composite Scaffolds for Bone Tissue EngineeringN. HASIRCI, Middle East Technical University, ANKARA, TurkeyA. E. Aksoy, Middle East Technical University, Ankara, TurkeyV. HASIRCI, Middle East Technical University, Ankara, Turkey

Drug Delivery2-Cancer

Targeting and Treating Bone Metastases Using Layer-by-Layer FunctionalizedNanoparticlesS. Morton, Massachusetts Institute of Technology, Cambridge, MA

Engineering Cells and Their Microenvironments

Directing Stem Cell Fate in 3D through Cell Inert and Adhesive Diblock Copolymer DomainsA. J. Engler, UC San Diego, La Jolla, CAP. Viswanathan, The University of Sheffield, Sheffield, United Kingdom (Great Britain)S. Chirasatitsin, UC San Diego, La Jolla, CaliforniaK. Ngamkham, The University of Sheffield, Sheffield, United Kingdom (Great Britain)G. Battaglia, The University of Sheffield, Sheffield, United Kingdom (Great Britain)

A Multicellular 3D Heterospheroid Liver Tumor Model for Anti-Cancer Drug TestingD. S. Yip, New Jersey Institute of Technology (NJIT), Newark, NJ

Effect of Cell Ratio on Osteoclast and Osteoblast Differentiation in a Ceramic BoneSubstitute SystemD. T. Nguyen, Clemson University, Central, SCK. J. L. Burg, Clemson University, Clemson, South Carolina

Ischemic Preconditioning to Enhance Osteogenic-Angiogenic CouplingJ. Blanchette, University of South Carolina, Columbia, SCS. Sahai, University of South Carolina, Columbia, South CarolinaA. Williams, University of South Carolina, Columbia, South CarolinaM. Skiles, University of South Carolina, Columbia, South CarolinaB. Hanna, University of South Carolina, Columbia, South Carolina

Bioactivity of a multivalent cell membrane binder in 3D spheroid culture: effects of RGD-

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dendrimer conjugate on cell proliferation, expression and aggregationL. Jiang, College of Engineering, Peking University, China, Beijing, ChinaY. Luo, College of Engineering, Peking University, China, Beijing, China

Immobilization of ephrinB2 in an orientation-regulated manner on the surface of hydrogelswith different elasticitiesM. Yamamoto, Kyoto University, Kyoto, JapanH. Toda, Kyoto University, Kyoto, JapanY. Tabata, Kyoto University, Kyoto, Japan

Protection and Functionalization of Cell Surfaces Using Nano-Barrier FilmsM. Matsusaki, Osaka University, Osaka, JapanT. Yoshikai, Osaka University, Osaka, JapanA. Matsuzawa, Mitsubishi Paper Mills Limited, Kyoto, JapanM. Akashi, Osaka University, Osaka, Japan

"Co-endocytic" delivery of proteins via artificial receptor/ligand interaction on cell surfaceT. Mori, Kyushu University, Fukuoka, Japan

Time Course, Spatial Distribution, and Patterns of Spontaneous Spiking Activity of ChickForebrain Neuronal Network Cultured on Microelectrode Array PlatformZ. Gao, Clemson University, Clemson, SC

Synthetic extracellular matrix for investigating 3D vascular network formationM. P. Schwartz, University of Wisconsin-Madison, Madison, WIJ. Zhang, Morgridge Institute for Research, Madison, WisconsinZ. Hou, Morgridge Institute for Research, Madison, WisconsinD. G. Belair, University of Wisconsin-Madison, Madison, WisconsinA. W. Xie, University of Wisconsin-Madison, Madison, WisconsinM. R. Zanotelli, University of Wisconsin-Madison, Madison, WisconsinE. H. Nguyen, University of Wisconsin-Madison, Madison, WisconsinJ. A. Thomson, Morgridge Institute for Research, University of Wisconsin-Madison, University ofCalifornia-Santa Barbara, Madison, WisconsinW. L. Murphy, University of Wisconsin-Madison, Madison, Wisconsin

Transient Expression of Neurogenin-2 through Nanoparticles Enhances NeuronalDifferentiation of Human Embryonic Stem Cell-Derived Neural ProgenitorsX. Li, Johns Hopkins University, Baltimore, MD

Directing Neural Stem Cell Recruitment: Crosstalk Signaling Between ECM and SDF-1αS. Stabenfeldt, Arizona State University, Tempe, AZC. P. Addington, Arizona State University, Tempe, ArizonaC. Pauken, Arizona State University, Tempe, ArizonaM. R. Caplan, Arizona State University, Tempe, Arizona

Engineering Instructive Cues Biomaterials

Expression of Sonic Hedgehog in Non-Diabetic Wounds Treated with Poly(Methacrylic Acid-co-Methyl Methacrylate)A. Lisovsky, University of Toronto, Toronto, ON, CanadaM. V. Sefton, University of Toronto, Toronto, Ontario, Canada

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Synergistic Effect of Silicon and Calcium Ions on Osteogenic Differentiation of HumanAdipose Stem CellsA. I. Rodrigues, 3Bs Research Group, University of Minho, Portugal, Caldas das Taipas -Guimarães, PortugalM. B. Oliveira, 3Bs Research Group, Caldas das Taipas - Guimarães, PortugalJ. F. Mano, 3Bs Research Group, Caldas das Taipas - Guimarães, PortugalM. E. Gomes, 3Bs Research Group, Caldas das Taipas - Guimarães, PortugalI. B. Leonor, 3Bs Research Group, Caldas das Taipas - Guimarães, PortugalR. L. Reis, 3Bs Research Group, Caldas das Taipas - Guimarães, Portugal

Vesicle Trafficking as a Mechanism to Sense and Respond to Nanofiber ArchitectureA. M. Higgins, The Pennsylvania State University, University Park, PA

Developing Grafted Poly(γ-propargyl L-glutamate) as a Platform to Present Nano-ClusteredExtracellular CuesC. M. Chopko, Massachusetts Institute of Technology, Cambridge, MAJ. Valdez, Massachusetts Institute of Technology, Cambridge, MassachusettsP. Hammond, Massachusetts Institute of Technology, Cambridge, MassachusettsL. Griffith, Massachusetts Institute of Technology, Cambridge, Massachusetts

Heterogeneous polymer surfaces with organized collagen layers influence preosteoblastsbehaviorC. Dupont-Gillain, Université catholique de Louvain, Louvain-la-Neuve, BelgiumE. Zuyderhoff, Université catholique de Louvain, Louvain-la-Neuve, Belgium

Cellular Orientation Control Using Microcontact Printing and Mechanical Conditioning forTissue Engineered Blood Vessels for AtherosclerosisE. L. Lee, Boston University, Boston, MAH. H. Bendre, Boston University, Boston, MassachusettsJ. Y. Wong, Boston University, Boston, Massachusetts

Combinatorial Screening of Cell Response to Surface Chemistry Gradient on a SoftBiomaterialG. Mohan, University of South Florida, Tampa, FLN. D. Gallant, University of South Florida, Tampa, Florida

Development of hydrogels functionalized with cell adhesive peptide and growth factors forcontrol of endothelial cell activities for therapeutic angiogenesisH. Shin, Hanyang University, Seoul, Republic of Korea

Microengineered Hydrogels for Directing Mesenchymal Stem Cell FateK. A. Kilian, University of Illinois at Urbana-Champaign, Urbana, IL

Isotropic and Directed hMSCs Migration Within a Three-dimensional, Peptide-Functionalized PEG HydrogelK. A. Kyburz, BioFrontiers Institute, University of Colorado, Boulder, COJ. A. Young, University of Colorado, Boulder, ColoradoK. S. Anseth, BioFrontiers Institute and the Howard Hughes Medical Institute, University ofColorado, Boulder, Colorado

Films of varying methacrylic acid content modulate gene expression in dTHP1 andendothelial cellsL. A. Wells, University of Toronto, Toronto, ON, Canada

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M. S. Valic, University of Toronto, Toronto, Ontario, CanadaM. V. Sefton, University of Toronto, Toronto, Ontario, Canada

Epithelial cyst phenotype is modulated by synthetic hydrogel elastic properties andadhesive ligand densityN. O. Enemchukwu, Georgia Institute of Technology, Atlanta, GAA. J. Garcia, Georgia Institute of Technology, Atlanta, Georgia

Functionalized fibronectin and RGD Titanium alloy surfaces used for IntraosseousTranscutaneous Amputation Prostheses in vitroR. P. Dowling, University College London, Stanmore, United Kingdom (Great Britain)C. J. Pendegrass, University College London, Stanmore, United Kingdom (Great Britain)G. W. Blunn, University College London, Stanmore, United Kingdom (Great Britain)

Development of In Situ Crosslinked Electrospun Gelatin ScaffoldsR. M. Nezarati, Texas A&M University, College Station, TXC. M. Radzicki, Texas A&M University, College Station, TexasE. Cosgriff-Hernandez, Texas A&M University, College Station, Texas

An Engineered Inert Matrix for In-Vitro Maintenance of Cancer Stem CellsS. K. Sarvestani, University of South Carolina, Columbia, SCX. Yang, University of South Carolina, Columbia, South CarolinaE. Jabbari, University of South Carolina, Columbia, South Carolina

Design and Characterization of Porous MMP-sensitive Synthetic Hydrogels by GelatinLeaching for Neovascularization ApplicationsS. Sokic, Illinois Institute of Technology, Chicago, ILM. Christenson, Illinois Institute of Technology, Chicago, IllinoisJ. Larson, Illinois Institute of Technology, Chicago, IllinoisG. Papavasiliou, Illinois Institute of Technology, Chicago, Illinois

Decellularized Tissue Extracellular Matrices: a Potential Source of Biomaterials for TissueEngineeringY. S. Takeda, Tufts University, Medford, MAQ. Xu, Tufts University, Medford, Massachusetts

Top-Down Synthesis of Versatile Polyaspartamide Linkers for Single-step ProteinConjugation to MaterialsC. Cha, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MAJ. Jeong, University of Illinois, Urbana, IllinoisH. Kong, University of Illinois, Urbana, Illinois

How Do Polymeric Implants Fail?

Clinical Implications of Crosslinked UHMWPE Implants with Stress Concentrations: ARetrievals AnalysisF. Ansari, University of California, Berkeley, Berkeley, CAE. Patten, University of California, Berkeley, Berkeley, CaliforniaJ. Chang, University of California, Berkeley, Berkeley, CaliforniaS. Chou, University of California, Berkeley, Berkeley, CaliforniaA. Mehdizadeh, University of California, Berkeley, Berkeley, CaliforniaM. Kury, University of California, Berkeley, Berkeley, California

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J. I. Huddleston III, Stanford University Medical Center, Redwood City, CaliforniaB. A. Jewett, Slocum Center for Orthopedics & Sports Medicine, Eugene, OregonD. Mickelson, University of Washington, Seattle, WashingtonH. Kim, University of California, San Francisco, San Francisco, CaliforniaM. Ries, University of California, San Francisco, San Francisco, CaliforniaL. Pruitt, University of California, Berkeley, Berkeley, California

Bearing Surface Damage Analysis of Coupled Total Shoulder Replacement RetrievalsL. Malito, University of California, Berkeley, Berkeley, CAF. Ansari, University of California, Berkeley, Berkeley, CaliforniaA. Mehdizadeh, University of California, Berkeley, Berkeley, CaliforniaJ. Koller, University of California, Berkeley, Berkeley, CaliforniaS. G. Gunther, Martha Jefferson Hospital, Charlottesville, VirginiaT. Norris, San Francisco Shoulder, Elbow & Hand Clinic, San Francisco, CaliforniaM. Ries, University of California, San Francisco, San Francisco, CaliforniaL. Pruitt, University of California, Berkeley, Berkeley, California

Load Dependent Creep Behavior & Its Relationship to Crystallinity in Absorbable MaterialsM. L. Dreher, FDA/CDRH, Silver Spring, MD

Hydrogels for Cellular Transplantation in the Central Nervous System

Cell-Seeded Injectable Gelatin-Hydroxyphenylpropionic Acid Hydrogel for the Regenerationof RetinaS. Rokkappanavar, Harvard Medical School, Jamaica Plain, MAT. Lim, Harvard-MIT Division of Health Sciences and Technology, Jamaica Plain, MassachusettsJ. Chen, Massachusetts Eye and Ear Infirmary, Boston, MassachusettsM. Kurisawa, Institute of Bioengineering and Nanotechnology, Singapore, SingaporeM. Spector, Harvard Medical School, Jamaica Plain, Massachusetts

Image Analysis in Implant Pathology Investigation

X-ray Phase Contrast Imaging of Hydrogels for Tissue EngineeringA. A. Appel, Illinois Institute of Technology, Chicago, ILJ. C. Larson, Illinois Institute of Technology, Chicago, IllinoisA. B. Garson, III, Washington University in St. Louis, St. Louis, MissouriB. Jiang, Illinois Institute of Technology, Chicago, IllinoisA. Zysk, Illinois Institute of Technology, Chicago, IllinoisM. O. Wang, University of Maryland, College Park, MarylandB. B. Nguyen, University of Maryland, College Park, MarylandE. C. Opara, Wake Forest Institute for Regenerative Medicine, Winston-Salem, North CarolinaJ. Fisher, University of Maryland, College Park, MarylandM. A. Anastasio, Washington University in St. Louis, St. Louis, MissouriE. Brey, Illinois Institute of Technology, Chicago, Illinois

Long-Term Wear Analysis of Retrieved Medially-Pivoting TKA InsertsW. C. Clem, Wright Medical Technology, Inc., Arlington, TN

Implant Pathology

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Decoy Protein Delivery from Titanium ImplantsM. Keeney, Stanford University, Stanford, CAZ. Yao, Stanford University, Stanford, CaliforniaK. Egashira, Kyushu University, Fukuoka, JapanS. B. Goodman, Stanford University, Stanford, CaliforniaF. Yang, Stanford University, Stanford, California

Orthopaedic Wear Particle Disease and NFκB SignalingZ. Yao, Stanford University School of Medicine, Stanford, CAM. Keeney, Stanford University School of Medicine, Stanford, CaliforniaJ. K. Antonios, Stanford University School of Medicine, Stanford, CaliforniaC. Li, Stanford University School of Medicine, Stanford, CaliforniaR. L. Smith, Stanford University School of Medicine, Stanford, CaliforniaF. Yang, Stanford University School of Medicine, Stanford, CaliforniaK. Egashira, Kyushu University, Fukuoka, JapanS. B. Goodman, Stanford University School of Medicine, Stanford, California

Magnetic Capture of Endothelial Cells to Vascular Stents Within An Externally AppliedMagnetic FieldB. J. Tefft, Mayo Clinic, Rochester, MNS. Uthamaraj, Mayo Clinic, Rochester, MinnesotaJ. Y. Gooden, Mayo Clinic, Rochester, MinnesotaJ. J. Harburn, Durham University, Stockton, United Kingdom (Great Britain)M. Klabusay, St. Anne's University Hospital, Brno, Czech RepublicD. R. Holmes, Jr., Mayo Clinic, Rochester, MinnesotaR. D. Simari, Mayo Clinic, Rochester, MinnesotaD. Dragomir-Daescu, Mayo Clinic, Rochester, MinnesotaG. S. Sandhu, Mayo Clinic, Rochester, Minnesota

Longevity of Implant-Associated Infectious BiofilmsA. M. Tatara, Rice University, Houston, TXF. K. Kasper, Rice University, Houston, TexasA. G. Mikos, Rice University, Houston, Texas

Hippocampal Neurogenesis is Down-Regulated in Animals with Small-Scale NervousSystem ImplantsM. B. Christensen, University of Utah, Salt Lake City, UTB. D. Winslow, University of Utah, Salt Lake City, UtahA. E. Higgins, University of Utah, Salt Lake City, UtahP. A. Tresco, University of Utah, Salt Lake City, Utah

Nanomaterials

Intracellular Behavior of Biodegradable Dextran-graft-oligo(lactide) Nanogels Collapsingunder Reductive Condition in Cytosol for Efficient Cellular Drug DeliveryA. Takahashi, Kansai University, Suita, Osaka, JapanA. Kuzuya, Kansai University, Suita, Osaka, JapanY. OHYA, Kansai University, Suita, Osaka, Japan

Graphene coated substrates for cell attachment and proliferationA. Aryaei, university of Toledo, Toledo, OH

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A. Jayatissa, University of Toledo, Toledo, OhioM. Gautam, University of Toledo, Toledo, OhioA. Jayasuriya, University of Toledo, Toledo, Ohio

Engineering thermo-responsive nano-shellsD. Cohn, The Hebrew University of Jerusalem, Jerusalem, Israel

Nanotechnology-derived catheters for reduced inflammation and infectionL. Liu, Northeastern University, Boston, MA, Boston, MA

Brazilian Spider Silk Protein Masp2 Production in E.coli System with Synthetic BiologyV. A. Michalczechen-Lacerda, University of Brasília, Brasilia, BrazilV. A. Michalczechen-Lacerda, University of Brasília, Brasília, BrazilO. Tokareva, Tufts University, Medford, MassachusettsG. R. Vianna, Embrapa Genetics Resources and Biotechnology, Brasilia, BrazilA. M. Murad, Embrapa Genetics Resources and Biotechnology, Brasilia, BrazilD. L. Kaplan, Tufts University, Medford, MassachusettsE. L. Rech, Embrapa Genetics Resources and Biotechnology, Brasília, Brazil

Preparation of Positively and Negatively Charged Nanogels Using Oligolactide-graftedPolysaccharides and Their Polyion Complex FormationY. Yano, Kansai university, Suita, Osaka, JapanA. Furuhata, Kansai University, Suita, JapanA. Takahashi, Kansai University, Suita, JapanA. Kuzuya, Kansai University, Suita, JapanY. Ohya, Kansai University, Suita, Japan

The micro/nano-sized bioactive glasses and their cytological behavioursC. Mao, South China University of Technology, Gainesville, FL

Efficacy of Novel Active Targeting Dendrimer for Paclitaxel Delivery to Breast Cancer CellsA. Satsangi, University of Texas at San Antonio, Helotes, TXJ. L. Ong, University of Texas at San Antonio, San Antonio, TexasS. Roy, University of Texas Health Science Center at San Antonio, San Antonio, TexasR. Vadlamudi, University of Texas Health Science Center at San Antonio, San Antonio, Texas

Nanostructured Biomaterials and Porous Scaffolds

Micro- to Nano-patterned Titanium Improves and Guides In Vitro Adhesion of Bone MarrowStromal CellsA. F. Cipriano, University of California, Riverside, Riverside, CAN. De Howitt, University of California, Riverside, Riverside, CaliforniaS. C. Gott, University of California, Riverside, Riverside, CaliforniaM. P. Rao, University of California, Riverside, Riverside, CaliforniaH. H. Liu, University of California, Riverside, Riverside, California

Posterolateral Fusion in a New Zealand White Rabbit ModelB. M. Schlossberg, Pioneer Surgical, woburn, MA

Design of surfaces with mechanical nanoheterogeneities for a better control of cell-material interactionsC. Dupont-Gillain, Université catholique de Louvain, Louvain-la-Neuve, Belgium

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S. Degand, Université catholique de Louvain, Louvain-la-Neuve, Belgium

Synthesis and Characterization of Antiepileptic Nanomedicine for Transbuccal DeliveryD. C. Aduba, Jr., Virginia Commonwealth University, Richmond, VAO. Y. Zolotarskaya, Virginia Commonwealth University, Richmond, VirginiaG. Bowlin, Virginia Commonwealth University, Richmond, VirginiaH. Yang, Virginia Commonwealth University, Richmond, Virginia

Microfabricated Nanoporous Gold Electrodes for Triggered Drug ReleaseE. Seker, University of California, Davis, Davis, CAC. A. R. Chapman, University of California, Davis, Davis, California

Composite Chitosan/Silk Fibroin Nanofibers for Osteogenic Differentiation of HumanMesenchymal Stem CellsG. Lai, Department of Chemical and Materials Engineering, Chang Gung University, Tao-Yuan, TaiwanJ. Chen, Department of Chemical and Materials Engineering, Chang Gung University, Tao-Yuan,Taiwan

Injectable Nano-hybrid Scaffold for Biopharmaceuticals Delivery and Tissue EngineeringH. Tan, Nanjing University of Science and Technology, Nanjing, China

Controlling the porosity of electrospun PCL scaffold by Simultaneous Salt releasing MethodJ. Lee, Nano-Bio Regenerative Medical Institute, Hallym University, Chuncheon, Republic ofKorea

Bioskiving: Fabrication of Tendon-derived Collagen Nerve Guidance MaterialsK. A. Alberti, Tufts University, Medford, MAQ. Xu, Tufts University, Medford, Massachusetts

Rosette nanotube composites for cartilage applicationsL. Sun, Northeastern University, Boston, MA

Femtosecond Laser-Patterned Nanopore Arrays for Spatio-Temporal Control of BioactiveMolecule ReleaseL. H. Hofmeister, Vanderbilt University, Nashville, TNA. Zachman, Vanderbilt University, Nashville, TennesseeL. Costa, University of Tennessee Space Institute, Tullahoma, TennesseeT. Boire, Vanderbilt, Nashville, TennesseeW. Hofmeister, University of Tennessee Space Institute, Tullahoma, TennesseeH. Sung, Vanderbilt University, Nashville, Tennessee

Poly (ethylene glycol)-poly(3,4- ethylenedioxythiophene):poly (styrenesulfonate) HydrogelNanofibers for Sensitive Detection of GlucoseM. Abidian, Pennsylvania State University, University Park, PAG. B. Kim, Pennsylvania State University, State College, Pennsylvania

Response of chitosan/PCL nanofibers with airway epithelial cellsN. Bhattarai, North Carolina A&T State University, Greensboro, NC

On the Use of Dexamethasone Loaded Liposomes to Induce the Osteogenic Differentiationof Human Mesenchymal Stem CellsN. S. Monteiro, 3B´s Research Group – Biomaterials, Biodegradables and Biomimetics,

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Release of Bioactive Agent from Liposomes Immobilized on Electrospun NanofibersTargeting Tissue Engineering ApplicationsN. S. Monteiro, 3B´s Research Group – Biomaterials, Biodegradables and Biomimetics,Guimaraes, Portugal

Directional Cell Migration Induced by Electrospun Silk NanofibersP. Uttayarat, Thailand Institute of Nuclear Technology (Public Organization), Nakornnayok,Thailand

Nanofiber-based Wound Dressings for Controlled Release of Hydrophilic DrugsV. Leung, University of British Columbia, Richmond, BC, Canada

Hydrogel Composites Containing Carbon Nanobrushes as an Effective Biomaterial for TissueRegenerationW. H. Marks, Harvard University, Cambridge, MAS. C. Yang, University of Rhode Island, Kingston, Rhode IslandG. W. Dombi, University of Rhode Island, Kingston, Rhode IslandS. K. Bhatia, Harvard University, Cambridge, Massachusetts

Multi-drug delivery system based on injectable hyaluronic acid-liposome hybrid hydrogelX. Yang, Uppsala University, Uppsala, Sweden

Bundle Structure Gel Formation Using the Co-flow Microfluidic DeviceY. Takahashi, The University of Tokyo., Tokyo, JapanN. Kato, Utsunomiya University, Utsunomiya, JapanY. T. Matsunaga, The University of Tokyo, Tokyo, Japan

Structural, Mechanical and In Vitro Characterization of Plasma-Coated ElectrospunNanofiber Scaffolds for Vascular Graft ApplicationsH. Savoji, 1- École Polytechnique de Montréal, 2- Laboratory of Endovascular Biomaterials(LBeV), Research Centre, Centre Hospitalier de l’Université de Montreal (CRCHUM),Montreal, QC, CanadaA. Hadjizadeh, École Polytechnique de Montréal, Montreal, Québec, CanadaM. Maire, Laboratory of Endovascular Biomaterials (LBeV), Research Centre, Centre Hospitalier del’Université de Montreal (CRCHUM), Montreal, Montreal, Québec, CanadaS. Lerouge, 1- École de Technologie Supérieure, 2- Laboratory of Endovascular Biomaterials(LBeV), Research Centre, Centre Hospitalier de l’Université de Montreal (CRCHUM), Montreal,Québec, CanadaA. Ajji, École Polytechnique de Montréal, Montreal, Québec, CanadaM. R. Wertheimer, École Polytechnique de Montréal, Montreal, Québec, Canada

Degradation of Ultrasound Contrast Agents Embedded in a Tissue PhantomS. Gleeson, Case Western Reserve University, Cleveland, OHL. Solorio, Case Western Reserve University, Cleveland, OhioA. A. Exner, Case Western Reserve University, Cleveland, Ohio

New and Improved Biomaterials Used in Ophthalmology

Ocular Biocompatibility of a SIBS-based Glaucoma Drainage TubeY. P. Kato, InnFocus Inc, Miami, FL

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Surface-Modified Silicone Contact Lenses from Interfacial Design to Clinical EvaluationZ. Zhang, Semprus BioSciences, Cambridge, MAJ. Li, Semprus BioSciences, Cambridge, MassachusettsH. Wang, Semprus BioSciences, Cambridge, MassachusettsD. Donahue, Semprus BioSciences, Cambridge, MassachusettsC. Loose, Semprus BioSciences, Cambridge, MassachusettsA. Cook, Semprus BioSciences, Cambridge, Massachusetts

Poly(ethylene glycol) based Diels-Alder hydrogels for biomedical applicationsA. Goepferich, University of Regensburg, Regensburg, Germany

Orthopaedic Biomaterials

Nanoclay Enriched Electrospun Polycaprolactone Scaffolds for Bone Tissue EngineeringA. Gaharwar, Massachusetts Institute of Technology, Cambridge, MAS. Mukundan, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsA. Patel, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsS. Mihaila, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsA. Dolatshahi-Pirouz, Brigham and Women’s Hospital, Harvard Medical School, Cambridge,MassachusettsE. Karaca, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsK. Ragaranjan, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MassachusettsA. Khademhosseini, Brigham and Women’s Hospital, Harvard Medical School, Cambridge,Massachusetts

Clinical Relevance of ISO 18192-1 Spinal Disc Wear Parameters to the PCM Cervical DiscSystemA. W. L. Turner, NuVasive, Inc., San Diego, CA

Fretting Corrosion Analysis of Ti-Mo-Zr-Fe (TMZF) and Gas Atomized DispersionStrengthened Co-Cr-Mo (GADS) Alloys Under Shot Peened, and Shot Peened, Cleaned andPassive ConditionsA. J. Ferrel, Syracuse University, Syracuse, NY

Surface Cross-linking of Vitamin E Blended UHMWPE by Low Energy IrradiationA. Neils, Massachusetts General Hospital, Boston, MAJ. Ward, Massachusetts General Hospital, Boston, MassachusettsB. Doshi, Massachusetts General Hospital, Boston, MassachusettsE. Oral, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

The initial concentration of vitamin E in irradiated UHMWPE affects vitamin E graftingA. Neils, Massachusetts General Hospital, Boston, MAE. Oral, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Fabrication of Crosslinked Carboxymethylchitosan Microspheres and Their IncorporationInto Composite Scaffolds for Enhanced Bone RegenerationB. Reves, University of Memphis, Germantown, TNJ. A. Jennings, University of Memphis, Memphis, TennesseeJ. D. Bumgardner, University of Memphis, Memphis, Tennessee

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W. O. Haggard, University of Memphis, Memphis, Tennessee

Strength and Friction Characteristics of a Porous Structured Titanium BiomaterialB. S. Mitchell, Pipeline Orthopedics, cedar knolls, NJD. F. Swarts, Pipeline Orthopedics, cedar knolls, New Jersey

Diffusion of Vitamin E in Radiation Cross-linked UHMWPE using Homogenization underPressureB. Doshi, Massachusetts General Hospital, Boston, MAE. Oral, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Bioactivity of Amorphous Bioactive Glass and Glass-Ceramic in Simulated Body FluidC. S. Lewis, Bio2 Technologies, Woburn, MAJ. Krevolin, Bio2 Technologies, Woburn, Massachusetts

0243-000037107Novel Porous Titanium Implants Demonstrate Bone Ingrowth In A RabbitModelC. Ngo, Stryker Orthopaedics, Mahwah, NJR. Zhang, Stryker Orthopedics, Mahwah, New JerseyM. Poggie, Stryker Orthopaedics, Mahwah, New JerseyG. Kulesha, Stryker Orthopaedics, Mahwah, New JerseyJ. Muth, Stryker Orthopaedics, Mahwah, New JerseyC. Aponte, Stryker Orthopaedics, Mahwah, New JerseyS. Coyle, Stryker Orthopaedics, Mahwah, New JerseyN. Dong, Stryker Orthopaedics, Mahwah, New Jersey

Surface Crosslinking of Vitamin E Blended UHMWPE via Spatial Extraction of Vitamin EThrough High Temperature ProcessingC. Gupta, Massachusetts General Hospital, Boston, MAE. Oral, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Poly(vinyl alcohol)-poly(2-acrylamido-2-methyl-1-propane sulfonic acid) hydrogels as asynthetic cartilage materialC. Serrano, Massachusetts General Hospital, Boston, MAH. Bodugoz-Senturk, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Physical and Mechanical Characteristics of a Porous Structured Titanium BiomaterialD. F. Swarts, Pipeline Orthopedics, Cedar Knolls, NJ

Osseointegration Effect of BMP-2 on Dental Implants: A 3-6 Week In Vivo StudyD. Y. Yoo, New York University College of Dentistry, New York, NYC. Marin, Universidade Federal de Santa Catarina, Florianopolis, BrazilR. Jimbo, Malmo University, Malmo, SwedenR. Anchieta, New York University College of Dentistry, New York, New YorkL. Machado, New York University College of Dentistry, New York, New YorkF. Guastaldi, New York University College of Dentistry, New York, New YorkN. Tovar, New York University College of Dentistry, New York, New YorkP. G. Coelho, New York University College of Dentistry, New York, New York

Vitamin-E highly crosslinked UHMWPE wear particles induce less osteolysis compared tovirgin UHMWPE in murine calvarial bone model

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D. Bichara, Massachusetts General Hospital, Boston, MAE. Malchau, Massachusetts General Hospital, Boston, MassachusettsN. Sillesen Hylleholt, Massachusetts General Hospital, Boston, MassachusettsS. Cakmak, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Bond Quality and Corrosion Properties of Titanium Foam on Cobalt Chrome SubstratesD. Scholvin, Wright Medical Technology, Inc., Arlington, TNJ. P. Moseley, Wright Medical Technology, Inc., Arlington, TennesseeD. Linton, Wright Medical Technology, Inc., Arlington, Tennessee

Effect of Irradiation on the Strength and Lubricity of PVA-PAA Hydrogels for CartilageRepairD. Ling, Massachusetts General Hospital, Boston, MAH. Bodugoz-Senturk, Massachusetts General Hospital, Boston, MassachusettsH. Kluk, Masachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

A New Technique for Surface Cross-linked UHMWPE by Diffusion of PeroxidesE. Oral, Massachusetts General Hospital, Boston, MAR. Gul, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Oxidation Resistant Peroxide Crosslinked UHMWPEE. Oral, Massachusetts General Hospital, Boston, MAR. Gul, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Coefficient of Friction for Porous Metal Structures Against Cortical BoneG. Gupta, Biomet, Warsaw, INK. McKlain, Biomet, Warsaw, Indiana

Novel Microwave Assisted Route for Preparing Monetite Bone Cement with No HeatGenerationH. Zhou, The University of Toledo, Toledo, OHS. B. Bhaduri, The University of Toledo, Toledo, OhioT. J. F. Luchini, The University of Toledo, Toledo, OhioA. K. Agawal, The University of Toledo, Toledo, OhioV. K. Goel, The University of Toledo, Toledo, Ohio

Fabrication of Customized Porous Hydroxyapatite (HA) implants for OrthopaedicApplicationH. Jung, Department of Materials Science and Engineering, Seoul National University,Seoul, Republic of KoreaT. Jang, Department of Materials Science and Engineering, Seoul National University, Seoul,Republic of KoreaM. Kang, Department of Materials Science and Engineering, Seoul, Republic of KoreaH. Kim, Department of Materials Science and Engineering, Seoul National University, Seoul, Republicof KoreaY. Koh, Department of Materials Science and Engineering, Seoul National University, Seoul, Republicof KoreaY. Estrin, cDepartment of Materials Engineering, Monash Univers, Seoul, Australia

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Impact Strength Correlates with Fatigue Strength of Irradiated Vitamin E/UHMWPE BlendsJ. Ward, Massachusetts General Hospital, Boston, MAB. Doshi, Massachusetts General Hospital, Boston, MassachusettsE. Oral, Massachusetts General Hospital, Boston, MassachusettsO. Muratoglu, Massachusetts General Hospital, Boston, Massachusetts

Magnesium ions facilitate integrin alpha-2 and alpha-3-mediated proliferation andpartially promotes differentiation in hBMSCsK. Lee, Asan Medical Center, Seoul, Republic of Korea

Engineering the Rate of Degradation of Polyester Scaffolds for Bone Tissue EngineeringK. N. Cicotte, University of New Mexico, Albuquerque, NMS. M. Dirk, Sandia National Laboratories, Albuquerque, New MexicoE. L. Hedberg-Dirk, University of New Mexico, Albuquerque, New Mexico

A Co-Polymer of Chitosan and Dextran Coating on Ti6Al4V for Orthopedic ApplicationsL. Actis, The University of Texas at San Antonio, San Antonio, TXA. Srinivasan, The University of Texas at San Antonio, San Antonio, TexasA. Ramasubramanian, The University of Texas at San Antonio, San Antonio, TexasJ. L. Ong, The University of Texas at San Antonio, San Antonio, Texas

A Clinically Relevant Oxidation Model for UHMWPE and its Comparison to RetrievalsM. Fung, Massachusetts General Hospital, Boston, MAO. Muratoglu, Massachusetts General Hospital, Boston, MassachusettsS. Rowell, Massachusetts General Hospital, Boston, MassachusettsA. Neils, Massachusetts General Hospital, Boston, MassachusettsE. Oral, Massachusetts General Hospital, Boston, Massachusetts

Bioactive PEEKS. Ajami, UCL, University College London, STANMORE, MIDDLESEX, United Kingdom (GreatBritain)M. Coathup, UCL, Stanmore, Middlesex, United Kingdom (Great Britain)A. McCabe, Accentus, Oxfordshire, United Kingdom (Great Britain)J. Shawcross, Accentus, Oxfordshire, United Kingdom (Great Britain)P. Agg, Accentus, Oxfordshire, United Kingdom (Great Britain)G. Blunn, UCL, Stanmore, Middlesex, United Kingdom (Great Britain)

Injectable, Bioactive Two-solution Bone Cements (η-TSBC) with Strontium SubstitutedHydroxyapatite MicrospheresS. Jariwala, Syracuse University, Syracuse, NYJ. Hasenwinkel, Syracuse University, Syracuse, New York

The Effect of Silica-substitution, Sintering and Particle Size on Bone Healing of ApatiteGranulesS. Woods, DePuy Synthes, West Chester, PAA. Petticoffer, DePuy Synthes, West Chester, PennsylvaniaD. Arens, AO Research Institute, Davos, Switzerland

Wear Rates of Ultra High Molecular Weight Polyethylene (UHMWPE) uncorrelated toContact AreaS. A. Woods, DePuy Orthopaedics, Warsaw, IN

Comparative Handling, Intrusion and Antibiotic Elution Characteristics of a New, High

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Viscosity Bone CementS. He, Stryker Co, Mahwah, NJS. He, Stryker Co, Mahwah, New JerseyH. Mulvihill, Stryker Co, Limerick, IrelandY. Bogatch, Stryker Co, Mahwah, New JerseyE. O'Grandy, Stykrer Co, Limerick, IrelandD. McQueen, Kansas Orthopaedic Center, Wichita, Kansas

Cell-mediated degradable hydrogels tailored to adult cells for cartilage tissue engineeringS. C. Skaalure, University of Colorado, Boulder, COS. J. Bryant, University of Colorado, Boulder, Colorado

A Comparison of Small Punch Results on Aged Highly Crosslinked UHMWPES. Spiegelberg, Cambridge Polymer Group, Boston, MAC. Segura, Cambridge Polymer Group, Boston, MassachusettsM. Peiserich, Zimmer, Inc., Warsaw, IndianaA. Rufner, Zimmer, Inc., Warsaw, Indiana

Radiation-Induced Radicals in Polyaryletheretherketone (PEEK)T. Riahinasab, University of Memphis, Memphis, TNB. Walters, University of Memphis, Memphis, TennesseeM. S. Jahan, University of Memphis, Memphis, Tennessee

Real-time Monitoring of Hardening of Nanosilica Sol containing DCPA Cements in an ESEMH. Zhou, The University of Toledo, Toledo, OHH. Zhou, The University of Toledo, Toledo, OhioS. Bhaduri, The University of Toledo, Toledo, OhioT. J. F. Luchini, The university of toledo, Findlay, Ohio

Effect of UHMWPE Patellar Component Thickness on Quadriceps Tendon Force FollowingTotal Knee ArthroplastyX. Xie, Clemson University, Clemson, SCJ. DesJardins, Clemson University, Clemson, South CarolinaH. Yao, Clemson University, Charleston, South CarolinaL. Thompson, Clemson University, Clemson, South CarolinaF. Voss, University of South Carolina, School of Medicine, Columbia, South CarolinaM. LaBerge, Clemson University, Clemson, South Carolina

Porous polyurethane scaffold for facilitating healing in critical sized bone defectY. Lui, The University of Hong Kong, Hong Kong, Hong KongW. Ip, The University of Hong Kong, Hong Kong, Hong Kong

Reducing Cytotoxicity of Injectable Poly(propylene-co-caprolactone) Copolymers for BoneTissue EngineeringZ. Fang, Mayo Clinic, Rochester, MN

Comparison of the Fixation Strength of PEEK and Composite Knotless Instability AnchorsM. Hawkins, Stryker Orthopaedics, Mahwah, NJJ. Spalazzi, Stryker Orthopaedics, Mahwah, New Jersey

Enhanced Bioactivity of PEEK by Accelerated Neutral Atom Beam TechniqueM. H. Maxwell, Exogenesis Corporation, Billerica, MAS. Kirkpatrick, Exogenesis Corporation, Billerica, Massachusetts

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R. Svrluga, Exogenesis Corporation, Billerica, MassachusettsJ. Khoury, Exogenesis Corporation, Billerica, Massachusetts

A Biomechanical Study to Compare an All-Suture Anchor to a Composite Suture Anchor inSheep Cadaver HumeriJ. N. Bair, IMDS Discovery Research, Logan, UTR. E. Olsen, IMDS Discovery Research, Logan, UtahJ. Pugsley, IMDS Discovery Research, Logan, UtahK. Pilgeram, Stryker Orthopaedics, San Jose, California

Biomechanical Testing of Soft Tissue Allografts Sterilized Using Two Different MethodsM. Hawkins, Stryker Joint Preservation, Mahwah, NJC. Kevin, University of Colorado - Denver, Aurora, ColoradoT. Baldini, University of Colorado - Denver, Aurora, ColoradoE. McCarty, University of Colorado - Denver, Aurora, Colorado

Comparison of Silicated–Apatite and β-TCP Granules in a Critical Size Bone Defect ModelA. C. Petticoffer, Depuy Synthes, West Chester, PAS. A. Woods, Depuy Synthes, West Chester, PennsylvaniaM. Fulmer, Depuy Synthes, West Chester, PennsylvaniaR. Harten, Depuy Synthes, West Chester, Pennsylvania

Cationic, Multifunctional Dendrimers for Treatment of OsteoarthritisB. G. Cooper, Boston University, Boston, MAM. W. Grinstaff, Boston University, Boston, MassachusettsC. Ghobril, Boston University, Boston, Massachusetts

Contrast Enhanced Computed Tomography of Equine Joint Cartilage DemonstratesConsistent Imaging Relationships Across Joint SurfacesR. Stewart, Boston University, Allston, MAB. Nelson, Colorado State University, Fort Collins, ColoradoH. Lusic, Boston University, Boston, MassachusettsB. Snyder, Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston,MassachusettsL. Goodrich, Colorado State University, Fort Collins, ColoradoM. Grinstaff, Boston University, Boston, Massachusetts

Engineering a Muscle Mimetic Extracellular Matrix BiomaterialS. Hurd, University of Arkansas, Fayetteville, ARB. Kasukonis, University of Arkansas, Fayetteville, ArkansasK. Cherry, University of Arkansas, Fayetteville, ArkansasS. Ahmadi, University of Arkansas for Medical Sciences, Little Rock, ArkansasJ. Wolchok, University of Arkansas, Fayetteville, Arkansas

Fabrication and Characterization of Poly(para-phenylene) for use as a Porous ScaffoldBiomaterialC. P. Frick, University of Wyoming, Laramie, WYA. L. DiRienzo, University of Wyoming, Laramie, WyomingC. M. Yakacki, University of Colorado at Denver, Denver, ColoradoD. L. Safranski, MedShape Solutions, Inc., Atlanta, Georgia

Degradation and characterization of porous constructs for craniofacial space maintenanceand antibiotic delivery

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A. Henslee, Rice University, Houston, TX

Patterning Microenvironments for Tissue Engineering and Morphogenesis

Biomechanics of Cell Sheets Based Arterial Tissue using a Novel Force SensorD. E. Backman, Boston University, Boston, MAJ. Y. Wong, Boston University, Boston, Massachusetts

Orthogonal Photo-reactive Hydrogel of Tunable Stiffness for In Vitro Guided NeuriteGrowthE. L. Horn-Ranney, Tulane University, New Orleans, LAP. Khoshakhlagh, Tulane University, New Orleans, LouisianaM. J. Moore, Tulane University, New Orleans, Louisiana

Two-Dimensional Micropatterns of Self-Assembled Poly(N-isopropylacrylamide) Microgelsfor Adhesion, Alignment, and Temperature-induced Detachment of NIH 3T3 Fibroblast CellsH. Tsai, University of Rochester, Rochester, NYK. Vats, University of Rochester, Rochester, New YorkM. Z. Yates, University of Rochester, Rochester, New YorkD. S. W. Benoit, University of Rochester, Rochester, New York

Bioengineering a tendon-like substitute: adult stem cell behavior in aligned fibrousscaffolds and stimulating culturing environmentsM. T. Rodrigues, 3B's Research Group - University of Minho, Caldelas das Taipas -Guimarães, Portugal

A Contour-Based Approach Enables Individual Cell Identification for Cell-Material AnalysesM. E. Brasch, Syracuse University, Syracuse, NYR. M. Baker, Syracuse University, Syracuse, New YorkL. Manning, Syracuse University, Syracuse, New YorkJ. H. Henderson, Syracuse University, Syracuse, New York

Biomimetic substrate-dependent myogenic commitment of iPSC-derived cellsN. Hwang, Seoul National University, Seoul, Republic of KoreaE. Lee, Seoul National University, Seoul, Republic of Korea

Cell Motility and Persistence Controlled by Topography of Cell Culture SubstratesW. Tong, City University of Hong Kong, Hong Kong, Hong KongQ. Tand, City University of Hong Kong, Hong Kong, Hong KongS. Peng, City University of Hong Kong, Hong kong, Hong KongS. Pang, City University of Hong Kong, Hong Kong, Hong KongY. Lam, City University of Hong Kong, Hong Kong, Hong Kong

Selective cell patterning on photoactive electrospun meshesJ. S. Hersey, Boston University, Boston, MAM. W. Grinstaff, Boston University, Boston, Massachusetts

Effects of Blocking Cell-Cell and Cell-Matrix Interactions on Cardiac Cell MechanicalPropertiesA. Desai, Clemson University, Clemson, SCS. Deitch, Clemson University, Clemson, South CarolinaD. Dean, Clemson University, Clemson, South Carolina

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Physical Parameters in the Design of Drug Delivery Systems

Injectable Multiblock P(PF-co-CL) Copolymer and Dual Drug Delivery for Treatment of BoneDefectsM. Dadsetan, Mayo Clinic, Rochester, MN

Injectable and Degradable Sulfated Hyaluronic Acid Hydrogels for Sustained ProteinDeliveryV. Chuo, University of Pennsylvania, Philadelphia, PAB. Purcell, University of Pennsylvania, Philadelphia, PennsylvaniaS. M. Dorsey, University of Pennsylvania, Philadelphia, PennsylvaniaJ. A. Burdick, University of Pennsylvania, Philadelphia, Pennsylvania

Proteins and Cells at Interfaces

Quantification of the Influence of Protein-Protein Interactions on Adsorbed ProteinStructure and BioactivityA. A. Thyparambil, Clemson University, Clemson, SCY. Wei, Clemson University, Clemson, South CarolinaR. A. Latour, Clemson University, Clemson, South Carolina

Collection of prostaglandin E2 and leukotriene B4 from implanted microdialysis probesA. Diaz-Perez, University of Arkansas, Fayetteville, AR

Directing Macrophage Polarization with Microdialysis Probe Implants: Perfusion Fluid andIL-4 EffectsG. Bajpai, University of Arkansas, Fayetteville, AR

Interaction Forces Related to Protein Adsorption on Polymer Brush SurfacesS. Sakata, The University of Tokyo, Tokyo, JapanY. Inoue, The University of Tokyo, Tokyo, JapanK. Ishihara, The University of Tokyo, Tokyo, Japan

Recovering functionalities of deficient mucus with a polyethylene glycol-lectin conjugateT. Crouzier, Massachusetts Institute of Technology, Cambridge, MAK. Ribbeck, MIT, Cambridge, Massachusetts

Development of Tuned Interfacial Force Field Parameters in CHARMM for the AccurateMolecular Dynamics Simulation of Peptide Adsorption on Biomaterial SurfacesT. Abramyan, Clemson University, Clemson, SCJ. A. Snyder, Clemson University, Clemson, South CarolinaJ. A. Yancey, Clemson University, Clemson, South CarolinaS. J. Stuart, Clemson University, Clemson, South CarolinaR. A. Latour, Clemson University, Clemson, South Carolina

Role of Biological Factors in Osteoconduction and Bone Engineering

Synergistic effect of sustained release growth factors from PLGA microspheres and

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dynamic bioreactor flow on hMSC osteogenic differentiation in alginate scaffoldsB. B. Nguyen, University of Maryland, College Park, MDG. Della Porta, Università di Salerno, Fisciano, SA, ItalyE. Reverchon, Università di Salerno, Fisciano (Sa), ItalyJ. P. Fisher, University of Maryland, College Park, Maryland

Surface modified PLLA as drug delivery scaffold for bone regenerationM. Bosetti, Università del Piemonte Orientale "A. Avogadro", Novara, Italy

Influence of Bone Morphogenetic Protein-7 Encapsulated and Coated ChitosanMicroparticles on Osteoblasts Proliferation and DifferentiationV. P. R. Mantripragada, The University of Toledo, Toledo, OH

Stem Cell-Biomaterial Interactions

Stable Feeder- and Xeno-free Surfaces for Long-term Growth of Undifferentiated HumanEmbryonic Stem CellsA. R. DiIenno, Massachusetts Institute of Technology, Cambridge, MAA. M. Coclite, Massachusetts Institute of Technology, Cambridge, MassachusettsJ. R. Millman, Massachusetts Institute of Technology, Cambridge, MassachusettsJ. Tan, Massachusetts Institute of Technology, Cambridge, MassachusettsC. K. Colton, Massachusetts Institute of Technology, Cambridge, MassachusettsK. K. Gleason, Massachusetts Institute of Technology, Cambridge, Massachusetts

Elucidating the role of integrin α5 in mediating the therapeutic potency of circulatingangiogenic cells cultured on collagen matrixB. Vulesevic, University of Ottawa Heart Institute, Ottawa, ON, CanadaB. McNeill, University of Ottawa Heart Institute, Ottawa, Ontario, CanadaM. Ruel, University of Ottawa Heart Institute, Ottawa, Ontario, CanadaE. J. Suuronen, University of Ottawa Heart Institute, Ottawa, Ontario, Canada

Functional roles of microRNA 489 and 148b in hMSCs osteogenesis depend onmicroenvironment elasticity.. Yang, University of Colorado, Boulder, Boulder, COK. S. Anseth, University of Colorado, Boulder, Boulder, Colorado

Differentiation of Human Bone Marrow Mesenchymal Stem Cells on DecellularizedExtracellular Matrix MaterialsD. M. Hoganson, Washington University in St. Louis, St. Louis, MOA. M. Meppelink, Massachusetts General Hospital, Boston, MassachusettsC. J. Hinkel, Washington University in St. Louis, St. Louis, MissouriS. M. Goldman, DSM Biomedical, Exton, PennsylvaniaS. Liu, DSM Biomedical, Exton, PennsylvaniaJ. P. Gaut, Washington University in St. Louis, St. Louis, MissouriJ. P. Vacanti, Massachusetts General Hospital, Boston, Massachusetts

Biphasic Peptide Amphiphile Nanomatrix Scaffold for Enhanced Osteogenic ResponseH. Jun, University of Alabama at Birmingham, Birmingham, ALJ. Vines, University of Alabama at Birmingham, Birmingham, AlabamaD. Patel, University of Alabama at Birmingham, Birmingham, AlabamaJ. Anderson, University of Alabama at Birmingham, Birmingham,, AlabamaS. Gilbert, University of Alabama at Birmingham, Birmingham,, Alabama

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D. Lim, University of Alabama at Birmingham, Birmingham,, Alabama

The Effect of Fiber Size on the Neuronal Differentiation of Mouse Embryonic Stem CellsJ. M. Holzwarth, University of Michigan, Ann Arbor, MI

The Potential of Tissue Engineering in Maxillofacial Reconstruction Following Oral CancerTreatmentJ. Shaul, Clemson University, Central, SC

Novel Sugar-Glass Nanoparticles system for Biomolecules Stabilization and Delivery inTissue Engineering Applicationsj. Giri, Parffenbarg Research Center,, Gaithersburg, MD

Modified PEGDA Hydrogels to Promote Mesenchymal Stem Cell Adhesion In VitroK. M. Ferlin, University of Maryland, College Park, MDM. E. Prendergast, University of Maryland, College Park, MarylandD. S. Kaplan, Food and Drug Administration, Silver Spring, MarylandJ. P. Fisher, University of Maryland, College Park, Maryland

Effect of Titanium Nanotopography on Mesenchymal Stem Cell FateM. M. Beloti, School of Dentistry of Ribeirao Preto - University of Sao Paulo, Ribeirao Preto,BrazilR. B. Kato, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, BrazilF. S. de Oliveira, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto,BrazilM. Q. Hassan, School of Dentistry, University of Alabama at Birmingham, Birmingham, AlabamaP. T. de Oliveira, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto,BrazilA. L. Rosa, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil

Differentiation of Adipose Derived Stem Cells on Nanofibrous Collagen and Elastin MatricesM. J. Springer, University of Florida, Gainesville, FLJ. Allen, University of Florida, Gainesville, Florida

Multifunctional Scaffold for the Delivery of Neural Stem Cells to Promote Regeneration afterTraumatic Brain InjuryN. B. Skop, University of Medicine and Dentistry of New Jersey and New Jersey Institute ofTechnology, Newark, NJC. H. Cho, New Jersey Institute of Technology, Newark, New JerseyS. W. Levison, University of Medicine and Dentistry of New Jersey, Newark, New Jersey

Modulation of Cell Behaviour using Self–Assembled Binary Colloidal CrystalsP. Wang, Industrial Research Institute Swinburne (IRIS), Swinburne University ofTechnology, Hawthorn VIC, Australia, Melbourne, Australia

Viability and Function of Induced Pluripotent Stem (IPS) Cell-Derived Hepatocytes onBioprinted Gelatin ScaffoldsR. N. Shah, Northwestern University, Chicago, ILA. Rutz, Northwestern University, Chicago, IllinoisA. Jakus, Northwestern University, Chicago, IllinoisK. Chien, Northwestern University, Chicago, Illinois

The Effects of Mechanical Stimulation on Controlling and Maintaining Marrow Stromal Cell

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Differentiation into Vascular Smooth Muscle CellsR. Yao, Boston University, Watertown, MA

Patterned Polyethylene glycol Coatings for Peptide Presentation and Cellular AdhesionS. K. Schmitt, University of Wisconsin - Madison, Madison, WID. J. Ciancio, University of Wisconsin-Madison, Madison, WisconsinW. L. Murphy, University of Wisconsin - Madison, Madison, WisconsinP. Gopalan, University of Wisconsin - Madison, Madsion, Wisconsin

Functional analysis of zinc finger and BTB domain containing 16 (ZBTB16) duringosteoblastic differentiation of periodontal ligament-derived human multipotentmesenchymal stromal cellsS. Onizuka, Section of Periodontology, Department of Hard Tissue Engineering, GraduateSchool, Tokyo Medical and Dental University, Tokyo, Japan

Engineered Collagen-Glycosaminoglycan Scaffold Arrays for Understanding Regulators ofMSC FateS. R. Caliari, University of Illinois at Urbana-Champaign, Urbana, IL

Effect of Surface Chemistry on Stem Cell Response in 2-D vs. 3-D Cell Culture NichesS. Sarkar, National Institute of Standards and Technology, Gaithersburg, MDC. G. Simon, Jr., National Institute of Standards and Technology, Gaithersburg, MarylandR. I. Lock, National Institute of Standards and Technology, Gaithersburg, MarylandJ. P. Dunkers, National Institute of Standards and Technology, Gaithersburg, Maryland

Supplemental Magnesium Ions Altered Human Embryonic Stem Cell Morphology whileRetaining PluripotencyT. Nguyen, University of California, Riverside, Moreno Valley, CAC. Liew, University of California, Riverside, Riverside, CaliforniaH. Liu, University of California, Riverside, Riverside, California

Stem Cell-Based Meniscus Tissue Engineering Using a Hydrogel Form of DecellularizedMatrixX. Yuan, Columbia University, New York, NYD. E. Arkonac, Columbia University, New York, New YorkG. Vunjak-Novakovic, Columbia University, New York, New York

Formation of Embryoid Bodies with Controlled Sizes and Maintained Pluripotency in Three-Dimensional Alginate Inverse Opal ScaffoldsY. Zhang, Georgia Institute of Technology, Atlanta, GAY. Xia, Georgia Institute of Technology, Atlanta, Georgia

GHK-Modified Alginate Hydrogels Enhance VEGF Secretion by Mesenchymal Stem CellsK. Leach, UC Davis, Davis, CAM. Hughbanks, UC Davis, Davis, California

Surface Characterization and Modification

Surface Characterization of Nano-Features Induced by a Low Temperature OxidationMethodA. Cheng, Georgia Institute of Technology, Atlanta, GA

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Enzymatic pH Control enables Spatially Controlled CaP Deposition onto MicropatternedSurfacesA. W. G. Nijhuis, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands

An Approach for Assessing Scaffold HydrophobicityD. Munoz-Pinto, Rensselaer Polytechnic Institute, Troy, NYB. Grigoryan, Texas A&M University, College Station, TexasM. Grunlan, Texas A&M University, College Station, TexasM. S. Hahn, Rensselaer Polytechnic Institute, Troy, New York

Surface Functionalization of Cobalt-Chromium Alloy Using Phosphoric and PhosphonoaceticAcidsE. Thiruppathi, The University of South Dakota, Sioux Falls, SDJ. Peacock, The University of South Dakota, Sioux Falls, South DakotaG. Mani, The University of South Dakota, Sioux Falls, South Dakota

Surface roughness properties of a micro-textured carbide-coated CoCrMo implant alloyduring wearG. Ettienne-Modeste, University of Maryland, Baltimore County, Nottingham, MD

Surface modification of poly(D,L-lactic acid) scaffolds for orthopedic applications: a non-destructive route via diazonium chemistryH. Mahjoubi, McGill University, Montreal, QC, CanadaM. Cerruti, McGill University, Montreal, Québec, Canada

Nano-structured surface modification on Ti alloy by electron cyclotron resonance plasmaoxidationH. Masumoto, Tohoku University, Sendai, Japan

Inorganic/Organic Coating Layer to Induce Apatite Formation in DPBSI. Lee, Yonsei University, Seoul, Republic of Korea

Preparation and Characterization of Functional Polypyrrole ParticlesJ. Mao, Centre de recherché du CHU de Québec, Université Laval, Québec City, QC, Canada

Versatile surface modification of biomaterials using biocompatible and photoreactivephospholipid polymersK. Fukazawa, The University of Tokyo, Tokyo, Japan

Flexible Polyetherimide-Silica Hybrid Xerogel Coating on MagnesiumM. Kang, Department of Materials Science and Engineering, Seoul National University,Seoul, Republic of Korea, Seoul, Republic of Korea

QCM-D as an useful tool for the combined immobilization of cell adhesion peptide andgrowth factor on biomaterial surfaces.P. Thalla, École de technologie supérieure (ÉTS), Montreal, QC, Canada

Tricalcium phosphate embedded poly(vinylidene fluoride) coating on magnesium forbiomedical applicationsS. Kim, WCU Hybrid Materials Program, Department of Materials Science and Engineering,Seoul National University, Seoul, Korea., Seoul, Republic of KoreaH. Park, WCU Hybrid Materials Program, Department of Materials Science and Engineering, SeoulNational University, Seoul, Korea, Seoul, Republic of Korea

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H. Kim, WCU Hybrid Materials Program, Department of Materials Science and Engineering, SeoulNational University, Seoul, Korea., Seoul, Republic of Korea

Evaluating the Level of Adhesion and Optimizing Thermal Bonding between Nitinol Wireand Thermoplastic Polymer filmsS. Navada, College of Textiles,North Carolina State University, Raleigh, NC

Evaluating the Level of Adhesion and Optimizing Thermal Bonding between Nitinol Wireand Thermoplastic Polymer Films.S. Navada, College of Textiles, North Carolina State University, Raleigh, NC

Regulating Smooth Muscle Cells on Poly(ethylene glycol)-grafted Poly(epsilon-caprolactone) NetworksS. Wang, The University of Tennessee, Knoxville, TNX. Liu, The University of Tennessee, Knoxville, Tennessee

Versatile surface functionalization of inorganic materials with cyclic phosphoestersY. Iwasaki, Kansai University, Osaka, JapanY. Yamamoto, Kansai University, Osaka, JapanT. Shimomura, Kansai University, Osaka, Japan

Facile method of preparing of temperature-responsive cell culture surface by usingphotoinitiator immobilized polystyrene surfacesY. AKIYAMA, Tokyo Women's Medical University, Tokyo, Japan

Shear Stress-dependent Cell Detachment from Temperature-responsive Cell CultureSurfaces in Microfluidic DeviceZ. Tang, Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women’sMedical University, Tokyo, JapanZ. Tang, Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women’s MedicalUniversity, Tokyo, JapanY. Akiyama, Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women’sMedical University, Tokyo, JapanK. Itoga, Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women’s MedicalUniversity, Tokyo, JapanJ. Kobayashi, Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women’sMedical University, Tokyo, JapanT. Okano, Institute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women’sMedical University, Tokyo, Japan

Microporous Ti implant compact coated with hydroxyapatite produced by electro-discharge-sintering and electrostatic-spray-depositionY. Jo, Sejong University, Seoul, Republic of KoreaW. Lee, Sejong University, Seoul, Republic of KoreaS. Cheon, Sejong University, Seoul, Republic of KoreaY. Jo, Sejong University, Seoul, Republic of KoreaY. Kim, wonkwang health science university, Jeonbuk, Republic of Korea

Surface Micromechanical Testing Methods for Contact Lenses: Indentation, Friction andDehydrationJ. L. Gilbert, Syracuse University, Syracuse, NYE. A. Lewis, Syracuse University, Syracuse, New York

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Surface Functionalization of Nanomaterials for Therapy and Diagnostics

Angiotensin II-functionalized Quantum Dot Interactions with CellsA. Goepferich, University of Regensburg, Regensburg, Germany

Modifying the Surface Chemistry of pH-Responsive Expansile Nanoparticles for AlteredCirculation, Targeting and Efficacy Towards CancerM. Stolzoff, Boston University, Boston, MAA. H. Colby, Boston University, Boston, MassachusettsC. Ghobril, Boston University, Boston, MassachusettsJ. S. Hersey, Boston University, Boston, MassachusettsY. L. Colson, Brigham and Women's Hospital, Boston, MassachusettsT. M. Porter, Boston University, Boston, MassachusettsM. W. Grinstaff, Boston University, Boston, Massachusetts

Surface Modification of Biomaterials for Local Therapy and Diagnostics

Targeted Inhibition of HIV-1 Utilizing a Bioengineered Nanofibrous Polyester MaterialJ. Araya, Northeastern University, Ashland, MAL. Fitzgerald, Biosurfaces, Inc., Ashland, MassachusettsT. Phaneuf, Biosurfaces, Inc., Ashland, MassachusettsS. Pathan, Biosurfaces, Inc., Ashland, MassachusettsD. Nelson, Biosurfaces, Inc., Ashland, MassachusettsD. Thoresen, Saint Michael's College, Ashland, MassachusettsM. Bide, University of Rhode Island, Ashland, MassachusettsT. Phaneuf, Biosurfaces, Inc., Ashland, MassachusettsM. Phaneuf, Biosurfaces, Inc., Ashland, Massachusetts

Functionalized polyanhydride nanoparticles preserve protein stability and activate antigenpresenting cellsJ. E. Vela Ramirez, Iowa State University, Ames, IAR. Roychoudhury, Indiana University, Bloomington, IndianaH. Habte, Iowa State University, Ames, IowaM. Cho, Iowa State University, Ames, IowaN. Pohl, Indiana University, Bloomington, IndianaM. Wannemuehler, Iowa State University, Ames, IowaB. Narasimhan, Iowa State University, Ames, Iowa

Functionalization of Pentablock Copolymers with Pathogen-Mimicking Sugars for TargetedDeliveryJ. Adams, Iowa State University, Ames, IAS. Mallapragada, Iowa State University, Ames, IowaN. Pohl, Indiana University, Bloomington, IndianaM. Goswami, Iowa State University, Ames, Iowa

Selective Deposition of Conductive Polymer Films Using Agarose StampsE. E. Richards, The Pennsylvania State University, University Park, PAN. Madduri, The Pennsylvania State University, University Park, PennsylvaniaM. R. Abidian, The Pennsylvania State University, University Park, PennsylvaniaS. Majd, The Pennsylvania State University, University Park, Pennsylvania

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Mechanical Properties of Triclosan Containing Sol-gel Thin Films on Titanium AlloyH. Qu, University of Pennsylvania, Philadelphia, PA

A Strongly Adherent, Biocompatible, Efficacious Antimicrobial Coating for OrthopedicImplantsM. A. Schallenberger, Bacterin International, Inc., Belgrade, MTT. R. Meyer, Bacterin International, Inc., Belgrade, MontanaH. M. Lovick, Bacterin International, Inc., Belgrade, Montana

Lower critical solution temperature of copolymers of N-vinyl-2-caprolactam and itsderivative: effects of pH and polymer compositionsS. Tang, University of Tennessee, Knoxville, Knoxville, TNY. Cao, University of Tennessee, Knoxville, TennesseeS. Goddard, University of Tennessee, Knoxville, Knoxville, TennesseeW. He, University of Tennessee, Knoxville, Knoxville, Tennessee

Surface Modification Strategies for Antimicrobial Medical Devices

Comparison of Commercially Available Wound Drains in a Bacterial Migration Assay andAgar Infection ModelD. X. Denty, Bacterin International Inc., Belgrade, MTM. A. Schallenberger, Bacterin international Inc., Belgrade, MontanaT. R. Meyer, Bacterin International Inc., Belgrade, Montana

A Thermodynamic Approach to Engineering Antifouling SurfacesJ. T. Decker, University of Florida, Gainesville, FLC. M. Kirschner, University of Florida, Boulder, ColoradoC. Long, University of Florida, Gainesville, FloridaJ. Finlay, University of Birmingham, Birmingham, United Kingdom (Great Britain)M. Callow, University of Birmingham, Birmingham, United Kingdom (Great Britain)J. Callow, University of Birmingham, Birmingham, United Kingdom (Great Britain)A. Brennan, University of Florida, Gainesville, Florida

Fabricating antibacterial paper towels through the use of selenium nanoparticlesQ. Wang, Northeastern Univeristy, Boston, MA

Surgical Meshes - Recent Development and Application

A Preliminary Study on Effects of Cyclic Loading and In Vitro Degradation on Mesh PorosityM. Deng, Johnson & Johnson Global Surgery Group, Somerville, NJV. Zhou, Johnson & Johnson, Somerville, New JerseyE. Vailhe, Johnson & Johnson, Somerville, New JerseyJ. Flint, Johnson & Johnson, Somerville, New JerseyM. Deng, Johnson & Johnson, Somerville, New Jersey

The Role of Antioxidants in Biomaterials

Electron Beam Warm Irradiation Improves Oxidative Resistance and Grafting of BlendedVitamin E Polyethylene

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D. Pletcher, Zimmer, Inc., Warsaw, INM. Guo, Zimmer, Inc., Warsaw, IndianaA. Rufner, Zimmer, Inc., Warsaw, Indiana

Effects of Natural Antioxidants on Polyethylene Radicals in UHMWPEM. S. Jahan, University of Memphis, Memphis, TNB. Walters, University of Memphis, Memphis, TennesseeA. Ali, AgResearch Ltd., Christchurch, New ZealandA. Ghosh, AgResearch Ltd., Christchurch, New Zealand

Effect of Vitamin C on the Growth of Endothelial Cells for Stent and Vascular GraftApplicationsS. Kakade, The University of South Dakota, Sioux Falls, SDG. Mani, The University of South Dakota, Sioux Falls, South Dakota

Evaluation of Oxidation Induction Time as a Tool for Characterization of AO ContentM. A. Ross, DePuy Synthes Joint Reconstruction, Warsaw, INV. S. Narayan, DePuy Synthes Joint Reconstruction, Warsaw, Indiana

Tissue Engineering

Enzymatic Treatment of Minced Porcine Cartilage Improves Cellular Outgrowth and GAGProduction in 3D in vitro CulturesA. J. McNally, Exactech, Inc., Gainesville, FLC. Chapman, Exactech, Inc., Gainesville, FloridaK. Sly, Exactech, Inc., Gainesville, FloridaS. Lin, Exactech, Inc., Gainesville, Florida

The Effect of Adding a Hydrogel Porogen into a Poly(lactic-co-glycolic acid) ScaffoldA. Clark, University of Kentucky, Lexington, KY

Electrospinning of Chitosan and its Correlation with Degree of Deacetylation andRheological PropertyA. Nandgaonkar, North Carolina State University, Raleigh, NCW. Krause, North Carolina State University, Raleigh, North Carolina

Enhanced cell proliferation on controlled pore size of chitosan nanofibers matB. Gu, Korea Institute of Radiological and Medical Science, Seoul, Republic of KoreaS. Park, Korea Institute of Radiological and Medical Science, Seoul, Republic of KoreaM. Kim, Korea Institute of Radiological and Medical Science, Seoul, Republic of KoreaC. Kim, Korea Institute of Radiological and Medical Science, Seoul, Republic of Korea

Scaffold-mediated REST siRNA delivery of mussel-inspired nanofibers induces neuronaldifferentiation of stem cellsC. Sing Yian, Nanyang Technological University, Singapore, SingaporeP. Rujitanaroj, Nanyang Technological University, Singapore, SingaporeW. Low, Nanyang Technological University, Singapore, SingaporeK. Jinghao, Northwestern University, Evanston, IllinoisL. Dong-Keun, Northwestern University, Evanston, IllinoisP. B. Messersmith, Northwestern University, Evanston, Illinois

Surface Modification of Poly(ε-caprolactone) Scaffolds Fabricated via Selective Laser

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Sintering for Cartilage Regeneration in Craniofacial SurgeryC. Chen, Department of Chemical and Materials Engineering, Chang Gung University, Tao-Yuan 33302, Taiwan, ROC, Tao-Yuan, Taiwan

Liquified Capsules Encapsulating Microparticles to Provide Cell Adhesion Sites EnhanceCellular FunctionsC. R. Correia, 3B's Research Group - Biomaterials, Biodegradables and Biomimetics,University of Minho, Guimarães, PortugalR. L. Reis, 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University ofMinho, Guimarães, PortugalJ. F. Mano, 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University ofMinho, Guimarães, Portugal

Poly(butylene succinate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) blendnanofibers for skin tissue engineeringD. Sundaramurthi, SASTRA University, Thanjavur, IndiaU. Krishnan, SASTRA University, Thanjavur, IndiaS. Sethuraman, SASTRA University, Thanjavur, India

Gelatin-based Hydrogels as Potential Cellular Delivery Systems for Cardiac TissueEngineeringG. Camci-Unal, Harvard Medical School, Cambridge, MAN. Alemdar, Harvard Medical School, Cambridge, MassachusettsA. Khademhosseini, Harvard Medical School, Cambridge, Massachusetts

Fabrication of Anisotropic Cell Sheets for Designing Well-organized Myotube AssemblyH. Takahashi, Tokyo Women's Medical University, Tokyo, Japan

Co-culture of Human Gingival Fibroblasts and Vascular Endothelial Cells in a PerfusedDegradable/Polar/Hydrophobic/Ionic Polyurethane (D-PHI)J. W. C. Cheung, University of Toronto, Toronto, ON, CanadaC. A. G. McCulloch, University of Toronto, Toronto, Ontario, CanadaJ. Santerre, University of Toronto, Toronto, Ontario, Canada

Development of Interconnected PolyHIPEs for Injectable Bone GraftsJ. L. Robinson, Texas A&M University, College Station, TXR. S. Moglia, Texas A&M University, College Station, TexasM. C. Stuebben, Texas A&M University, College Station, TexasM. A. P. McEnery, Texas A&M University, College Station, TexasE. Cosgriff-Hernandez, Texas A&M University, College Station, Texas

Effects of Low Oxygen Tension during Expansion on Chondrogenic Potential ofOsteoarthritis ChondrocytesJ. Wang, Syracuse Biomaterials Institute and the Department of Biomedical and ChemicalEngineering, Syracuse University, Syracuse, NYK. Davis, Syracuse Biomaterials Institute and the Department of Biomedical and ChemicalEngineering Syracuse University, Syracuse, New YorkJ. Henderson, Syracuse Biomaterials Institute and the Department of Biomedical and ChemicalEngineering Syracuse University, Syracuse, New York

Tyrosine-Derived Polycarbonates to Treat a Rabbit Critical-Sized Segmental Bone DefectJ. Kim, Hongik University, Sejong, Republic of Korea

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Nanocomposite Bone Scaffolds Based on Biodegradable Polymers and HydroxyapatiteM. Dadsetan, Mayo Clinic, College of Medicine, Rochester MN; Paracelsus MedicalUniversity, Salzburg, Austria, Rochester, MN

Decellularized Human Vocal Fold as a Scaffold for Laryngeal Tissue EngineeringJ. R. Tse, University of California, Los Angeles, Cerritos, CAJ. L. Long, University of California, Los Angeles, Los Angeles, California

Tissue Engineered Model of the Inner Neural RetinaK. E. Kador, Bascom Palmer Eye Institute,University of Miami Miller School of Medicine,Miami, FLP. Venugopalan, Bascom Palmer Eye Institute,University of Miami Miller School of Medicine, Miami,FloridaR. B. Montero, University of Miami, Coral Gables, FloridaJ. Hertz, Bascom Palmer Eye Institute,University of Miami Miller School of Medicine, Miami, FloridaE. Lavik, Case Western Reserve University, Cleveland, OhioF. Andreopoulos, University of Miami, Coral Gables, FloridaJ. L. Goldberg, Bascom Palmer Eye Institute,University of Miami Miller School of Medicine, Miami,Florida

hMSC and Fibroblast Dispersion Cultures in Chitosan-based Injectable Hydrogels forCartilage RegenerationK. J. Walker, Oklahoma State University, Stillwater, OKS. V. Madihally, Oklahoma State University, Stillwater, Oklahoma

In Situ Crosslinkable Gelatin Hydrogel for Ex Vivo Organ Culture of Cardiac TissueK. Park, Ajou University, Suwon, Republic of KoreaK. Park, Ajou University, Suwon, Republic of KoreaY. Lee, Ajou University, Suwon, Republic of KoreaJ. Son, Ajou University, Suwon, Republic of KoreaY. Yang, Inje University School of Medicine, Busan, Republic of Korea

Preparation and characterization of soft tissue-polymer complex for percutaneous deviceK. Nam, Tokyo Medical and Dental University, Tokyo, JapanR. Matsushima, Tokyo Medical and Dental University, Tokyo, JapanY. Shimatsu, Tokyo Medical and Dental University, Tokyo, JapanT. Kimura, Tokyo Medical and Dental University, Tokyo, JapanT. Fujisato, Osaka Institute of Technology, Osaka, JapanA. Kishida, Tokyo Medical and Dental University, Tokyo, Japan

Smooth Muscle Cell Migration in 3D Biomimetic Poly(ethylene glycol) HydrogelsL. Lin, Case Western Reserve University, Cleveland Heights, OHJ. Zhu, Case Western Reserve University, Cleveland, OhioK. Kottke-Marchant, Cleveland Clicnic, Cleveland, OhioR. Marchant, Case Western Reserve University, Cleveland, Ohio

Responses of Vascular Endothelial Cells to Photo-embossed Topography on Polymer Filmsand FibersL. Qiu, Institute of Bioengineering, Queen Mary, University of London, London, UnitedKingdom, London, United Kingdom (Great Britain)

Pre-vascularized Gellan Gum-Hyaluronic Acid Spongy-like Hydrogels improve Skin woundhealing

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M. T. Cerqueira, 3B's Research Group, University of Minho, Caldas das Taipas, Guimarães,PortugalL. da Silva, 3B's Research Group, University of Minho, Caldas das Taipas, Guimarães, PortugalT. Santos, 3B's Research Group, University of MInho, Caldas das Taipas, Guimarães, PortugalR. Pirraco, 3B's Research Group, University of Minho, Caldas das Taipas, Guimarães, PortugalA. Martins, 3B's Research Group, University of Minho, Caldas das Taipas, Guimarães, PortugalV. Correlo, 3B's Research Group, University of Minho, Caldas das Taipas, Guimarães, PortugalA. P. Marques, 3B's Research Group, University of Minho, Caldas das Taipas, Guimarães, PortugalR. L. Reis, 3B's Research Group, University of Minho, Caldas das Taipas, Guimarães, Portugal

A new technique for Development of perfusable multilayered blood vessel-like structureson Microfluidic ChipM. Hasan, Harvard Medical School, Cambridge, MAG. Jeong, Harvard Medical School, Cambridge, Massachusetts

Processing and Storage Effects on Poly(ethylene glycol) Hydrogel Mechanical Propertiesand BioactivityP. Luong, Texas A&M University, College Station, TXM. Browning, Texas A&M University, College Station, TexasR. Bixler, Texas A&M University, College Station, TexasE. Cosgriff-Hernandez, Texas A&M University, College Station, Texas

Designing Degradable Microporous Bacterial Cellulose Scaffolds and its BiomimeticComposites for Bone and Cartilage Tissue EngineeringP. Favi, University of Tennessee - Knoxville, Knoxville, TN

Structural and Compositional Changes of Porcine Articular Cartilage After Partial EnzymaticDigestionP. Lee, Exactech Taiwan, Hsinchu, TaiwanC. Chen, Exactech Taiwan, Hsinchu, TaiwanK. Sly, Exactech Inc., Gainesville, FloridaS. Lin, Exactech Inc., Gainesville, Florida

Development of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibrous scaffold foresophageal tissue engineeringP. Kuppan, SASTRA University, Thanjavur, IndiaS. Sethuraman, SASTRA University, Thanjavur, IndiaU. Krishnan, SASTRA University, Thanjavur, India

Mechanical properties of stem cells from different sources during vascular smooth musclecell differentiationR. Chen, Clemson University, Clemson, SCD. Dean, Clemson University, Clemson, South Carolina

Combination Delivery of Small RNAs Enhances Muscle RegenerationS. Lee, Wake Forest School of Medicine, Winston-Salem, NCN. Kim, Wake Forest School of Medicine, Winston-Salem, North Carolina

Host Stem Cell Mobilization for In Situ Muscle Tissue RegenerationS. Lee, Wake Forest School of Medicine, Winston-Salem, NC

Biomechanics and Bioresorbable Material Study toward Pelvic Organ Prolapse CorrectiveMesh Design

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S. Aghyarian, Department of Chemistry and The Alan G. MacDiarmid NanoTech Institute,The University of Texas at Dallas, Richardson, TXC. Manz, Department of Materials Science and Engineering, The University of Texas at Dallas,Richardson, TexasA. Pereira, Department of Chemistry and The Alan G. MacDiarmid NanoTech Institute, TheUniversity of Texas at Dallas, Richardson, TexasN. Mammoottil, Department of Chemistry and The Alan G. MacDiarmid NanoTech Institute, TheUniversity of Texas at Dallas, Richardsoon, TexasC. Watson, Department of Chemistry and The Alan G. MacDiarmid NanoTech Institute, TheUniversity of Texas at Dallas, Rchardson, TexasB. Lund, Department of Chemistry and The Alan G. MacDiarmid NanoTech Institute, The Universityof Texas at Dallas, Richardson, TexasP. Zimmern, Department of Urology, The University of Texas Southwestern Medical Center, Dallas,TexasR. Eberhart, Department of Urology, The University of Texas Southwestern Medical Center, Dallas,TexasH. Tibbals, Department of Urology, The University of Texas Southwestern Medical Center, Dallas,TexasW. Voit, Department of Materials Science and Engineering, The University of Texas at Dallas;Department of Urology, The University of Texas Southwestern Medical Center, Dallas, TX 753904Department of Mechanical Engineering, The University of Texas at Dallas, Richardson, TexasD. Smith, Department of Chemistry and The Alan G. MacDiarmid NanoTech Institute, The Universityof Texas at Dallas; Department of Materials Science and Engineering, The University of Texas atDallas, Richardson, Texas

Structural Deformation Studies of Scaffolds and Method for Non-Invasively MonitoringTissue GrowthS. Madihally, Oklahoma State University, Stillwater, OKJ. Podichetty Thribhuvan, Oklahoma State University, Stillwater, Oklahoma

Enhancing Segmental Defect Regeneration through a Thrombopoietic AgentT. G. Chu, Indiana University School of Dentistry, Indianapolis, IN

Preparation and Characterization of Porcine Esophageal Extracellular MatrixT. Keane, University of Pittsburgh, Pittsburgh, PAR. Londono, University of Pittsburgh, Piitsburgh, PennsylvaniaR. Carey, University of Pennsylvania, Pittsburgh, PennsylvaniaJ. Reing, University of Pittsburgh, Pittsburgh, PennsylvaniaS. F. Badylak, University of Pittsburgh, Pittsburgh, Pennsylvania

Platelet-Derived Growth Factor Stimulated Migration of Bone Marrow Mesenchymal StemCells into an Injectable Gelatin-Hydroxyphenylpropionic Acid HydrogelW. Niu, VA Boston Healthcare System, Brigham and Women's Hospital, Boston, MA

Conductive Fabrics for Electrically Stimulated Cell CultureY. Wang, Laval University, Quebec, QC, CanadaM. Rouabhia, Laval University, Québec, Québec, CanadaZ. Zhang, Laval University, Québec, Québec, Canada

Rapid Formation of Engineered Microvasculatures Using Microfluidic TechniquesY. T. Matsunaga, The University of Tokyo, Tokyo, JapanN. Brandenberg, The University of Tokyo, Tokyo, JapanI. Matsuda, The University of Tokyo, Tokyo, Japan

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M. Umezu, Waseda University, Tokyo, JapanY. Okubo, The University of Tokyo, Tokyo, Japan

In Situ Forming Gelatin-Based Bioadhesive and Sprayable Hydrogels for Skin RegenerationY. Lee, Ajou University, Suwon, Republic of KoreaJ. Bae, Ajou University, Suwon, Republic of KoreaK. Park, Ajou University, Suwon, Republic of Korea

Minimally Invasive Spine Fracture Risk Prediction Based on QCT and Image AnalysisZ. Fang, Mayo Clinic, Rochester, MN

Small diameter acellular vascular grafts with integrin a4b1 positive cell-caputuring surfaceT. YAMAOKA, National Cerebral and Cardiovascular Center Research Institute, Suita, JapanS. Somekawa, National Cerebral and Cardiovascular Center Research Institute, Suita, JapanN. Kobayashi, National Cerebral and Cardiovascular Center Research Institute, Suita, JapanY. Hirano, Kansai University, Suita, JapanN. Mihashi, National Cerebral and Cardiovascular Center Research Institute, Suita, JapanT. Sakuma, National Cerebral and Cardiovascular Center Research Institute, Suita, JapanT. Moritan, Suzuka University of Medical Science, SuzukaSuzuka, JapanY. Kimura, Kyoto Institute of Technology, Kyoto, JapanT. Fujisato, Osaka Institute of Technology, Osaka, JapanA. Mahara, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan

Translational Research in Nano-biomaterials

Histologic and Histomorphometric Analysis of Two Graft Materials in a Non-instrumentedCanine Interspinous Spinal Fusion ModelA. S. Ismailoglu, NuVasive Inc., San Diego, CAH. Yuan, University of Twente, Enschede, NetherlandsF. Vizesi, NuVasive Inc., San Diego, CaliforniaX. Luo, University of Twente, Enschede, NetherlandsJ. de Bruijn, University of Twente, Enschede, NetherlandsE. Erbe, NuVasive Inc., San Diego, California

Characterization of Porcine Vascular Tissue and Gold Nanoparticles as a Vascular GraftMaterialA. M. Ostdiek, University of Missouri, Columbia, MOS. Grant, University of Missouri, Columbia, Missouri

Carbon Nanotube-Polyimide Composite Microneedles for Rapid Transdermal Drug DeliveryB. J. Lyon, California Institute of Technology, Pasadena, CAA. Aria, California Institute of Technology, Pasadena, CaliforniaM. Gharib, California Institute of Technology, Pasadena, California

Nanosilver Surfaces for Improved Understanding of Biocompatibility and AntibacterialEfficacy of Medical Device CoatingsE. M. Sussman, U.S. Food and Drug Administration, Silver Spring, MDB. J. Casey, U.S. Food and Drug Administration, Silver Spring, MarylandJ. Zheng, U.S. Food and Drug Administration, Silver Spring, MarylandB. J. Dair, U.S. Food and Drug Administration, Silver Spring, MarylandD. V. Patwardhan, U.S. Food and Drug Administration, Silver Spring, Maryland

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Microwave Assisted Synthesis of Alkaline Earth Phosphates NanospheresH. Zhou, The University of Toledo, Toledo, OHS. B. Bhaduri, The University of Toledo, Toledo, OhioT. J. F. Luchini, The University of Toledo, Toledo, Ohio

Microwave Assisted Alkaline Earth Phosphate Biomimetic Coating Deposition on ImplantsH. Zhou, The University of Toledo, Toledo, OHV. K. Goel, University of Toledo, Toledo, OhioS. B. Bhaduri, The University of Toledo, Toledo, Ohio

Auricular Reconstruction with a Novel Nanocomposite ScaffoldL. Nayyer, Univeresity College London (UCL), London, United Kingdom (Great Britain)

Fabrication of Novel Polylactic Acid/Amorphous Magnesium Phosphate BionanocompositeFibers for Tissue Engineering Applications via ElectrospinningM. Nabiyouni, University of Toledo, Toledo, OH

Regulation of Human Tendon Fibroblast Response by Fiber Diameter of ElectrospunPolymer ScaffoldsN. M. Lee, Columbia University, New York, NYC. Erisken, Columbia University, New York, New YorkW. N. Levine, Columbia University, New York, New YorkH. H. Lu, Columbia University, New York, New York

Nano-grafts for Anterior Cruciate Ligament ReconstructionS. E. Smith, University of Missouri, Columbia, MOS. Grant, University of Missouri, Columbia, MissouriR. White, University of Missouri, Columbia, Missouri

Tribocorrosion of Metallic Biomaterials

Factors Affecting the Performance of Metal Components in Artificial HipsO. Vesnovsky, U.S. Food and Drug Administration, Silver Spring, MDN. P. Anderson, U.S. Food and Drug Administration, Silver Spring, MarylandM. A. Di Prima, U.S. Food and Drug Administration, Silver Spring, MarylandC. A. Engh, Jr., Anderson Orthopaedic Institute, Alexandria, VirginiaL. W. Grossman, U.S. Food and Drug Administration, Silver Spring, MarylandR. Hopper, Anderson Orthopaedic Institute, Alexandria, VirginiaB. Stephen, U.S. Food and Drug Administration, Silver Spring, MarylandL. Topoleski, University of Maryland Baltimore County, Baltimore, Maryland

Wound Dressings That Do More Than Covering the Wounds

Development of Vancomycin-Linked Poly(β-amino ester) HydrogelsA. Vasilakes, University of Kentucky, Lexington, KYD. Puleo, University of Kentucky, Lexington, KentuckyJ. Hilt, University of Kentucky, Lexington, KentuckyT. Dziubla, University of Kentucky, Lexington, Kentucky

Dynamic Biomaterials for Healing Chronic Wounds

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B. D. Almquist, MIT, Cambridge, MAS. Castleberry, MIT, Cambridge, MassachusettsP. T. Hammond, MIT, Cambridge, Massachusetts

Multivalent Sonic Hedgehog-Hyaluronic Acid Conjugates for Enhanced NeovascularizationDuring Diabetic Wound HealingB. W. Han, University of California, Berkeley, Berkeley, CAW. Jackson, University of California, Berkeley, Berkeley, CaliforniaH. Layman, University of California, San Francisco, San Fancisco, CaliforniaN. A. Rode, University of California, Berkeley, Berkeley, CaliforniaD. Dashti, University of California, Berkeley, Berkeley, CaliforniaA. Conway, University of California, Berkeley, Berkeley, CaliforniaN. Boudreau, University of California, San Francisco, San Francisco, CaliforniaD. Schaffer, University of California, Berkeley, Berkeley, CaliforniaK. E. Healy, University of California, Berkeley, Berkeley, California

Decellularized Extracellular Matrix Microparticles Support Fibroblast Growth and are aVehicle for Cellular Delivery in a Model of Anastomosis HealingD. Hoganson, Washington University in St. Louis, St. Louis, MOG. E. Owens, California Institute of Technology, Pasadena, CaliforniaE. K. Bassett, Massachusetts General Hospital, Boston, MassachusettsA. M. Meppelink, Massachusetts General Hospital, Boston, MassachusettsC. Bowley, DSM Biomedical, Exton, PennsylvaniaC. J. Hinkel, Washington University in St. Louis, St. Louis, MissouriE. B. Finkelstein, Syracuse University, Syracuse, New YorkS. M. Goldman, DSM Biomedical, Exton, PennsylvaniaJ. P. Vacanti, Massachusetts General Hospital, Boston, Massachusetts

Development of Supercritical CO2-Treated Human Amniotic Membrane Combined withAdipose Derived Stem Cells for Wound TreatmentJ. Wehmeyer, U.S. Army Institute of Surgical Research, Fort Sam Houston, TX

Development of modified collagen films containing red propolis extracts to wound healingapplicationJ. C. Cardoso, Universidade Tiradentes, Watertown, MA

Controlling the Delivery of Vascular Endothelial Growth Factor and Platelet Derived GrowthFactorL. Kelly, University of Sheffield, Sheffield, United Kingdom (Great Britain)L. Platt, University of Sheffield, Sheffield, United Kingdom (Great Britain)S. MacNeil, University of Sheffield, Sheffield, United Kingdom (Great Britain)P. Genever, University of York, York, United Kingdom (Great Britain)S. Rimmer, University of Sheffield, Sheffield, United Kingdom (Great Britain)

AnastomoSEAL – Biopolymeric patches for the treatment of colorectal anastomosisM. Dornish, FMC BioPolymer AS, Sandvika, NorwayS. Paolettk, University of Trieste, Trieste, ItalyN. Bouvy, University of Maastricht, Maastricht, NetherlandsM. Bosco, SIGEA SRL, Trieste, ItalyM. Foulc, RESCOLL, Pessac, FranceW. Fediuk, I.E. "IMPULS", Gdansk, Poland

Absorbable Polyurethanes for Wound Healing Applications

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N. Srivastava, Bezwada Biomedical, LLC, Hillsborough, NJ

Factors Associated with the Ideal Donor Site Dressing for Burn Patients after Split-Thickness Skin GraftingR. Jindani, North Carolina State University, Raleigh, NC

Development of Mucoadhesive Films with Increased Residence Time for Treatment of LocalDisordersS. k. RAMINENI, University Of Kentucky, Lexington, KY, KY

Layer-by-Layer Delivery of siRNAS. Castleberry, Massachusetts Institute of Technology, Cambridge, MAP. Hammond, Massachusetts Institute of Technology, Cambridge, Massachusetts

Wound healing processes using Punica granatum Linn extracts incorporated in collagenbased filmsW. A. Araujo, Universidade Tiradentes, Watertown, MA

Antibacterial microfilm dressing with silver-nanoparticles promotes healing ofcontaminated excisional woundsA. Agarwal, Imbed Biosciences Inc, Madison, WIT. B. Nelson, Imbed Biosciences, Inc, Madison, WisconsinP. R. Kierski, University of Wisconsin-Madison, Madison, WisconsinM. Budianto, University of Wisconsin-Madison, Madison, WisconsinC. J. Murphy, University of California, Davis, Davis, CaliforniaM. J. Schurr, University of Colorado, Denver, Aurora, ColoradoC. J. Czuprynski, University of Wisconsin-Madison, Madison, WisconsinN. L. Abbott, University of Wisconsin-Madison, Madison, WisconsinJ. F. McAnulty, University of Wisconsin-Madison, Madison, Wisconsin

Evaluating Performance of Hydrogel-Based Adhesives for Soft Tissue ApplicationsL. Sanders, Clemson University, Clemson, SC

Use of Tryptophan to Prevent Pseudomonas aeruginosa Biofilm Growth on WoundDressingsK. S. Brandenburg, University of Wisconsin-Madison, Madison, WIJ. F. McAnulty, University of Wisconsin-Madison, Madison, WisconsinN. L. Abbott, University of Wisconsin-Madison, Madison, WisconsinC. J. Murphy, University of California-Davis, Davis, CaliforniaM. J. Schurr, University of Colorado-Denver, Aurora, ColoradoN. Shah, University of California-Davis, Davis, CaliforniaA. Agarwal, Imbed Biosicences Inc, Madison, WisconsinC. J. Czuprynski, University of Wisconsin-Madison, Madison, Wisconsin

Dendritic Hydrogels as Portable Systems for Hemostasis of Abdominal and ExtremityWoundsC. Ghobril, Boston University, Boston, MAA. Nazarian, Beth Israel Deaconess Medical Center, Boston, MassachusettsE. Rodriguez, Beth Israel Deaconess Medical Center, Boston, MassachusettsM. Grinstaff, Boston University, Boston, Massachusetts

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Biomaterials and Biotechnology: From the Discovery of the First Angiogenesis Inhibitors tothe Development of Controlled Drug Delivery Systems and the Foundation of Tissue EngineeringR. Langer, Massachusetts Institute of Technology

Technology, Service and Bucking Convention: A Prescription for a Rewarding Biomaterials Career

A. J. Coury, Coury Consulting Services, Boston, Massachusetts

The Regenerative Engineering Future: The Role of BiomaterialsC. T. Laurencin, University of Connecticut

Mechnikov, the Macrophage and the Man: James Anderson, Macrophages & Biomaterials andNew Results on Macrophage PhenotypesB. D. Ratners, University of Washington

In Vivo Glucose Sensors Modeled as a "Source-sink, Heterogeneous Matrix" Transport Problem:Is That All There Is?M. T. Novak, Duke University, Durham, NC

New Perspectives on Biocompatibility PathwaysD. Williams, Wake Forest Institute of Regenerative Medicine, Winston-Salem, NC

Osteogenic Differentiation of Mesenchymal Stem Cells on Demineralized and DevitalizedBiodegradable Polymer and Extracellular Matrix Hybrid ConstructsR. A. Thibault, Rice University, Houston, TX

D. H. Koch, Massachusetts Institute of Technology

F. Yuan, Duke University, Durham, NCW. M. Reichert, Duke University, Durham, NC

974 Mussel-Inspired Catechol Biomaterials for Surgical Repair and Drug DeliveryP. B. Messersmith, Northwestern University, Evanston, IL

975 Bio-Inspired Materials for the Treatment of Arterial Disease

E. L. Chaikof, Johnson and Johnson Professor of Surgery, HarvardS. R. Weiner, Beth Israel Deaconess Medical Center

976 Biomimetic Approaches for Regeneration

P. X. Ma, University of Michigan

A. G. Mikos, Rice University, Houston, TXF. K. Kasper, Rice University, Houston, TX

Plenary Papers