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IBR CLEARLY BRIGHT Complex Skin Lightening, Whitening & Evening of Skin Tone
IBR CLEARLY BRIGHT Complex for
Skin Lightening, Whitening & Evening of Skin Tone
Skin lightening, whitening & even skin tone
A Global Trend
Whiter, flawless has always been associated with
health, nobility, purity and younger perception of age.
People of all cultures seek
effective lightening skin care products.
effective skin whitening and lightening ingredients complex
IBR CLEARLY BRIGHT Complex
Hyper pigmentation is a complex, multi stage and multi component
process.
An ideal agent for battling hyper pigmentation would attack the process in
a multitude of stages.
IBR CLEARLY BRIGHT Complex Hyper Pigmentation And Ways To Control It
IBR CLEARLY BRIGHT Complex Hyper Pigmentation – Melanin Synthesis Pathway
Receptor Tyrosinase
Ac-vated Tyrosinase
Tyrosine DOPAQuinone
Eumelanins
Melanosomes
UV
Inflamma0on
NO, free radicals,
Superoxide ions
PGE-‐2, IL-‐1, IL-‐6
Wound
Melanocyte
Melanocyte Prolifera0on
Kera0nocyte
Receptor
ET-‐1
Receptor Tyrosinase
Ac-vated Tyrosinase
Tyrosine DOPAQuinone
Eumelanins Melanosomes
UV
Inflamma0on
NO, free radicals,
Superoxide ions
PGE-‐2, IL-‐1, IL-‐6
Wound
Melanocyte
Melanocyte Prolifera0on
Kera0nocyte
Receptor
ET-‐1
IBR-Phyto(flu)ene, IBR-Dormin & IBR-Snowflake
can inhibit melanin synthesis
IBR CLEARLY BRIGHT Complex
IBR CLEARLY BRIGHT Complex
Interferes within a multitude of pigmentation pathways,
Addressing the pigmentation challenge from a variety of angles
IBR CLEARLY BRIGHT Complex Hyper Pigmentation And Ways To Control It
IBR-Phyto(flu)ene® Skin Lightening Effect in vitro
q Inhibition of melanin synthesis, a direct activity
q Control of pigmentation by anti inflammatory activity
q Reduction of melanin production by reduction of oxidative stress
q Reduction of skin darkening due to sun exposure by UVA/B
absorption
q Pigmentation control by reduction of UVB induced inflammation
by UVB absorption
à reduce at least 4 causes of pigmentation with IBR-Phyto(flu)ene®
IBR CLEARLY BRIGHT Complex
IBR CLEARLY BRIGHT Complex IBR-Phyto(flu)ene® Skin Lightening Effect in vitro
UV absorption Free Radical scavenging
IBR CLEARLY BRIGHT Complex IBR-Phyto(flu)ene® Skin Lightening Effect in vitro
ANTI INFLAMMATORY EFFECT OF IBR-PHYTO(FLU)ENE®
In vitro whitening effect Anti inflammatory
IBR-Dormin® Skin Lightening Effect in vitro
q Inhibition of melanocytes proliferation
q Control of melanin synthesis and pigmentation by
inhibition of Endothelin 1 (ET-1), whose expression in
keratinocytes is induced by UV
q Reduction of melanin production by reduction of
oxidative stress affecting nitric oxide
IBR CLEARLY BRIGHT Complex
IBR-Dormin® reduces proliferation of melanoma cell in culture
IBR CLEARLY BRIGHT Complex IBR-Dormin® Skin Lightening Effect in vitro
Narcissus Tazetta bulb extract (IBR-Dormin®) potently inhibits Endothelin-1 production by normal human keratinocytes in vitro. C. Lasserre, M. Mildner, C. Wallaert, E. Tschachler Skin Research and Technology 2004; 10: 1–16. Abstracts, 2004 US Symposium of the International Society for Bioengineering and the Skin
IBR-Dormin® inhibition of NO Sample IC50 (µg/ml) IBR-Dormin 4.41µg/ml (0.05%) &
6.21µg/ml (0.07%)
Quercetin Control <10 µg/ml
IBR CLEARLY BRIGHT Complex IBR-Dormin® Skin Lightening Effect in vitro
IBR-Snowflake® Skin Lightening Effect in vitro
q Inhibition of melanocytes proliferation
q Natural control of melanin synthesis and
pigmentation - reducing oxidative damage by boosting
Super Oxide Dismutase (SOD) expression leading to
elimination of SO ions
IBR CLEARLY BRIGHT Complex
0
20
40
60
80
100
120
140
0% 0,15%Mn SOD
In nature, skin eliminates oxidative stress through enzymes like SOD; IBR–Snowflake® significantly increases MnSOD in keratinocytes (*20% increase at 0.15% IBR-Snowflake®) improving the natural skin protection and reducing oxidative damages
IBR CLEARLY BRIGHT Complex IBR-Snowflake® Skin Lightening Effect in vitro
Mn SOD expression increase
A randomized, double blinded, placebo controlled study evaluating the
lightening effect of a cream comprising IBR CLEARLY BRIGHT Complex
was performed (x2/day application, 84 days, n=21)
IBR CLEARLY BRIGHT Complex in this study:
IBR-Dormin® all natural 0305 2%
IBR-Snowflake® all natural 1003 2%
IBR-TCLC® in jojoba oil 0705 3%
IBR CLEARLY BRIGHT Complex IBR CLEARLY BRIGHT Complex Skin Whitening Effect in vivo
IBR-‐Dormin®
IBR-‐TCLC®
IBR-‐Snowflake®
Result: a significant skin whitening effect
at both measured time points
IBR CLEARLY BRIGHT Complex IBR CLEARLY BRIGHT Complex Skin Whitening Effect in vivo
ITA° parameter variations
+7%
+13%
+3%
+10%
+0%
+2%
+4%
+6%
+8%
+10%
+12%
+14%
D42 D84
Var
iatio
ns in
%
740782(active product)
514345(placebo)
UV LIGHT ABSORBTION
FIGURE 4: PHYTOENE AND PHYTOFLUENE ABSORPTION SPECTRA
NEW! CLINICAL EVALUATION OF THE LIGHTENING EFFECT OF A COSMETIC PRODUCT CONTAINING PHYTOENE AND PHYTOFLUENE
A randomized, double blinded, placebo-controlled study evaluating the lightening effect of a cream containing IBR-TCLC® 5% was performed. A twice a day application during a 3 month course of treatment resulted in a significant skin whitening effect in both DAY-42 and DAY-84 (n=21).
* Full study report is available upon request.
RESULTS
after 42 and 84 days of twice daily use
SIGNIFICANT LIGHTENING EFFECT:
IBR CLEARLY BRIGHT Complex IBR CLEARLY BRIGHT Complex Skin Whitening Effect in vivo
IBR-Dormin® all natural 0305 2%
IBR-Snowflake® all natural 1003 2%
IBR-TCLC® in jojoba oil 0705 3%
IBR-TCLC® in jojoba oil 0705 5%
IBR CLEARLY BRIGHT Complex
Skin lightening, whitening & even skin tone
Result (x2/day application, 84 days, n=21) a significant skin whitening effect at both measured time
points
ac0ve product D 84 ac0ve product D 0
IBR CLEARLY BRIGHT Complex -
A multi functional complex of actives
IBR-Dormin® all natural 0305
IBR-Snowflake® all natural 1003
IBR-TCLC® in jojoba oil 0705
effectively and significantly
lightens the skin tone
protects the skin
keeps skin younger and younger looking
IBR CLEARLY BRIGHT Complex
IBR-‐Dormin®
IBR-‐TCLC®
IBR-‐Snowflake®
THANK YOU CONTACT
