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04/12/2014
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WP3: The Lothian Birth Cohort 1936 Dr Simon Cox [email protected]
Lothian Birth Cohort 1936? • Elderly, community dwelling adults living in the Lothian
area of Scotland.
• In 1947, all Scottish schoolchildren aged 11 sat the Moray House Test (MHT). • Represented a unique programme of Nationwide IQ testing.
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Sco@sh Council for Research and EducaEon (SCRE) basement
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The Sco@sh Mental Survey 1947’s ledgers
1947
Young adulthood
Old age
Test score
Healthy ageing?
Average decline?
Accelerated Decline?
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Young adulthood
Old age
Test score
Healthy ageing
Average decline
Accelerated Decline
Need This!
Lothian Birth Cohort 1936
Deary et al. (2011). Int J Epidemiol., 41(6), 1576-1584.
• Identified 1091 surviving participants of Scottish Mental Survey of 1947 Ø All born in 1936 Ø Moray House Test (MHT) Ø Living in the Lothian area
• Aim to conduct follow-up testing to:
characterise the nature, determinants and sequelae of cognitive ageing.
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LBC1936 at Wellcome Trust CRF, Edinburgh
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LBC1936 at Wellcome Trust CRF, Edinburgh
LBC1936 – The 8th Decade of Life
Inter-‐wave retenEon rate c.80%
Age 11
(n = 70,805)
Age 70
(n = 1,091)
Age 73(n = 866)
(MRI = 728)(CDU = 821)
Age 76(n = 697)
(MRI = 488)
Age 79(n ≈ 560)
(MRI ≈ 420)(CDU ≈ 540)
Detailed Cognitive Test Battery
16 tests: domains of memory, speed,
fluid, spatial, crystallised
Heath, Wellbeing, & Psychosocialmedical interview,
investigations, anthropometrics, physical function,
personality & other questionnaires
Genetics and GWAS
genotyping and Illumina 610 Quad
chip
EpigeneticsIllumina 450
Methylation chip
Biomarkersmultiple from blood & urine: metabolic,
inflammation, endocrine, etc.
Brain Imaging (MRI)Structural Parametersintracranial volume - brain tissue volume - hippocampal volume - cerebrospinal fluid volume - grey & white matter volume white matter hyperintensity volume & visual rating scores - cortical parcellation - cortical thickness - mineralization volume microbleed count - enlarged perivascular spaces
Tractographyfractional anisotropy - axial, radial & mean diffusivity - T1 - magnetisation transfer ratio
Carotid Doppler Ultrasound
(CDU)
Moray House Test of General
Cognitive Abilityand detailed social
background, demographics, and
education
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LBC1936 – The 8th Decade of Life
Inter-‐wave retenEon rate c.80%
Age 11
(n = 70,805)
Age 70
(n = 1,091)
Age 73(n = 866)
(MRI = 728)(CDU = 821)
Age 76(n = 697)
(MRI = 488)
Age 79(n ≈ 560)
(MRI ≈ 420)(CDU ≈ 540)
Detailed Cognitive Test Battery
16 tests: domains of memory, speed,
fluid, spatial, crystallised
Heath, Wellbeing, & Psychosocialmedical interview,
investigations, anthropometrics, physical function,
personality & other questionnaires
Genetics and GWAS
genotyping and Illumina 610 Quad
chip
EpigeneticsIllumina 450
Methylation chip
Biomarkersmultiple from blood & urine: metabolic,
inflammation, endocrine, etc.
Brain Imaging (MRI)Structural Parametersintracranial volume - brain tissue volume - hippocampal volume - cerebrospinal fluid volume - grey & white matter volume white matter hyperintensity volume & visual rating scores - cortical parcellation - cortical thickness - mineralization volume microbleed count - enlarged perivascular spaces
Tractographyfractional anisotropy - axial, radial & mean diffusivity - T1 - magnetisation transfer ratio
Carotid Doppler Ultrasound
(CDU)
Moray House Test of General
Cognitive Abilityand detailed social
background, demographics, and
education
