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8/10/2019 Seni Menulis Resep Presentation
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Time
A P B Q
C1
C2
Cm
D MEC
MTC
A-B Abs. Process
P-Q Duration of action
Cm Max. conc.
MEC Min. Effective conc.
MTC Min. toxic conc.AD Initial action
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F CTORS TH T FFECTED BO V IL BILITY
1. PATIENT CONDITION
Age, sex, pregnancy
Food, diet etc
2. PHARMACEUTICAL DOSAGE FORMDrug particle size, salt, ester
Vehicle
Drug dosage form, formula
PER ORAL:
Solution > suspension > capsule > tablet > coated tablet
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1 2 3 4 5 6
0.25
0.50
0.75
1.00
1.25
1.50
Concentration
Time
i.v
enema
tablet
Suppository
AMINOPHYLLINE
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THERAPEUTIC INCOMPATIBILITY
Response to one or more drugs in the patients is different or intensify
than that intended by the prescribers.
Resulted from:
Errors in writing prescription
Errors in interpreting prescription orders
e.g.Over dosage
Contraindicated drugs,
Synergistic effectsAntagonistic effects
Other drug interactions related to pharmacokineticand pharmacodynamic interactions
Pharmacist has to consult/give suggestion to the prescriber
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PHARMACEUTICAL INCOMPATIILITY
The arising problems during the compounding, dispensing or
administration of drugs can cause therapeutic incompatibility
PHYSICAL INCOMPATIBILITY:
Insolubility
Liquefaction
Physical complexion
CHEMICAL INCOMPATIBILITY:
Oxidationreduction
Acid base Hydrolysis
Combination reaction
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FORMULAS IN THE PRESCRIPTION
BENEFIT
F.SPECIALITIES- Already available faster
-Available in varied dosage
forms
F.OFFICINALIS-Single/composed drug:
effective, combined
ideally
-Not all drugs available in raw
material, if available in trade name
costly
-Not all dosage form can be
composed in pharmacy
RISK
-Relatively costly
-Possibly 1/more drugs in the formula
are not needed by the patient
redundant
- Not Developed
- only available in old books
published many years ago
- Old fashioned
F.MAGISTRALIS
-dose/drug can be determined
suitable with patient
- Drug in raw material
not costly
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WRITING PRESCRIPTION
M.D.
must
FORMULA
mag.FORMULA
spec.
FORMULA
off.
understand Drug properties
pharmacology,physical, chemical
Content,
comp., conc.,dosage
Content,
comp., conc.,dosage
know incompatibility incompatibility Official books
be capableto
determine
Therapeutic dose,dosage form, how
& time to adm.
Therapeutic dose,dosage form, how
& time to adm
Therapeutic dose,dosage form, how
& time to adm
write
prescription
Lege artis (l.a)
suitable with
dosage form
Trade name !!! write the name
of off.formula
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DRUG FUNCTION
1. REMEDIA CARDINALE = core drug
Function: to cure diseases
2. REMEDIA ADJUVANTIA
Function: symptomatic
3. REMEDIA CORRIGENTIA
R. Corr. Actionis = improving drug action
R. Corr. Saporis = making more palatable
R. Corr. Odoris = covering drug smellR. Corr. Coloris = improving drug colour
4. REMEDIA CONSTITUENT
Function: vehicle, filler