Seni Menulis Resep Presentation

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    Time

    A P B Q

    C1

    C2

    Cm

    D MEC

    MTC

    A-B Abs. Process

    P-Q Duration of action

    Cm Max. conc.

    MEC Min. Effective conc.

    MTC Min. toxic conc.AD Initial action

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    F CTORS TH T FFECTED BO V IL BILITY

    1. PATIENT CONDITION

    Age, sex, pregnancy

    Food, diet etc

    2. PHARMACEUTICAL DOSAGE FORMDrug particle size, salt, ester

    Vehicle

    Drug dosage form, formula

    PER ORAL:

    Solution > suspension > capsule > tablet > coated tablet

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    1 2 3 4 5 6

    0.25

    0.50

    0.75

    1.00

    1.25

    1.50

    Concentration

    Time

    i.v

    enema

    tablet

    Suppository

    AMINOPHYLLINE

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    THERAPEUTIC INCOMPATIBILITY

    Response to one or more drugs in the patients is different or intensify

    than that intended by the prescribers.

    Resulted from:

    Errors in writing prescription

    Errors in interpreting prescription orders

    e.g.Over dosage

    Contraindicated drugs,

    Synergistic effectsAntagonistic effects

    Other drug interactions related to pharmacokineticand pharmacodynamic interactions

    Pharmacist has to consult/give suggestion to the prescriber

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    PHARMACEUTICAL INCOMPATIILITY

    The arising problems during the compounding, dispensing or

    administration of drugs can cause therapeutic incompatibility

    PHYSICAL INCOMPATIBILITY:

    Insolubility

    Liquefaction

    Physical complexion

    CHEMICAL INCOMPATIBILITY:

    Oxidationreduction

    Acid base Hydrolysis

    Combination reaction

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    FORMULAS IN THE PRESCRIPTION

    BENEFIT

    F.SPECIALITIES- Already available faster

    -Available in varied dosage

    forms

    F.OFFICINALIS-Single/composed drug:

    effective, combined

    ideally

    -Not all drugs available in raw

    material, if available in trade name

    costly

    -Not all dosage form can be

    composed in pharmacy

    RISK

    -Relatively costly

    -Possibly 1/more drugs in the formula

    are not needed by the patient

    redundant

    - Not Developed

    - only available in old books

    published many years ago

    - Old fashioned

    F.MAGISTRALIS

    -dose/drug can be determined

    suitable with patient

    - Drug in raw material

    not costly

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    WRITING PRESCRIPTION

    M.D.

    must

    FORMULA

    mag.FORMULA

    spec.

    FORMULA

    off.

    understand Drug properties

    pharmacology,physical, chemical

    Content,

    comp., conc.,dosage

    Content,

    comp., conc.,dosage

    know incompatibility incompatibility Official books

    be capableto

    determine

    Therapeutic dose,dosage form, how

    & time to adm.

    Therapeutic dose,dosage form, how

    & time to adm

    Therapeutic dose,dosage form, how

    & time to adm

    write

    prescription

    Lege artis (l.a)

    suitable with

    dosage form

    Trade name !!! write the name

    of off.formula

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    DRUG FUNCTION

    1. REMEDIA CARDINALE = core drug

    Function: to cure diseases

    2. REMEDIA ADJUVANTIA

    Function: symptomatic

    3. REMEDIA CORRIGENTIA

    R. Corr. Actionis = improving drug action

    R. Corr. Saporis = making more palatable

    R. Corr. Odoris = covering drug smellR. Corr. Coloris = improving drug colour

    4. REMEDIA CONSTITUENT

    Function: vehicle, filler