By Dr Aijaz Ahmed Sohag

HOD Com Medicine Dept

Edit by: Abdulwasay Baloch

Amna Inayat Medical College

Randomized Control Trial (RCT)

Randomized Control Trial- RCT

Experiment methods where individuals are randomly allocated to an experimental or a control group

The effect or intervention is compare between the two groups

Two Key Features are: 1. Randomization

2. Controlled

These trials are BLINDED

Single blind means the patients do not know what the intervention is

Double blind means that netither the patient nor the researcher knows what the intervention or drug is

Triple blind means Analysis team also does not know which is experimental and which is control group

Plus Point of the Study

A unique strength of this study is that it eliminated both confounding bias both known and unknown

Drawbacks of RCT

External validity refers to extent to which the results can be generalized to a boarder community

For RCT , including person is first screened, then only they are included in trial – this may lead to that volunteers selected different from those who do not

RCT cannot be used in instances such as exposure to harm to harmful materials such as , Toxins, Bacteria