By Dr Aijaz Ahmed Sohag
HOD Com Medicine Dept
Edit by: Abdulwasay Baloch
Amna Inayat Medical College
Randomized Control Trial (RCT)
Randomized Control Trial- RCT
Experiment methods where individuals are randomly allocated to an experimental or a control group
The effect or intervention is compare between the two groups
Two Key Features are: 1. Randomization
2. Controlled
These trials are BLINDED
Single blind means the patients do not know what the intervention is
Double blind means that netither the patient nor the researcher knows what the intervention or drug is
Triple blind means Analysis team also does not know which is experimental and which is control group
Plus Point of the Study
A unique strength of this study is that it eliminated both confounding bias both known and unknown
Drawbacks of RCT
External validity refers to extent to which the results can be generalized to a boarder community
For RCT , including person is first screened, then only they are included in trial – this may lead to that volunteers selected different from those who do not
RCT cannot be used in instances such as exposure to harm to harmful materials such as , Toxins, Bacteria