President’s Message We are looking forward to seeing as many of you as possible in sunny San Antonio in just over a week. Good luck with your travel plans and presentations. If you are not able to travel this year, we will miss you. We wanted to get you some information that we’ll be sharing at the Annual Meeting so that you can use it to refine your meeting plans. RASS has been quite active this year, making some changes, improvements, etc. First, our awards chairs, Laurie Haws and John DeSesso moved the application deadline for papers and named awards (Doull, Gehring, Rubin) forward a few weeks to allow a more timely judging and notification process. Due to this change, we are proud to be able to announce our award winners before the meeting, so that you can make plans to view their presentations. Information on Student and Post Doctoral Award winners, Best Abstracts and Best Papers is contained herein, including abstract numbers, dates and times of presentations. These award-winning scientists will be recognized at our reception, Tuesday,

March, 2013

Volume 3, Issue 3

Officers

President John C. Lipscomb President-Elect John M. DeSesso Past President Robinan Gentry Vice President Laurie Haws Secretary - Treasurer Elaina Kenyon Councilors Bob Budinsky Nancy Beck Postdoctoral Representative Roxana Weil Student Representative Jose Anibal Torres Newsletter Editor Elaina Kenyon

Table of Contents ________________________

RASS Mixer …………………………………….…….3 Session Proposal Due Dates for 2014……..……...…….10 Arnold Lehman Award Winner ……………….……....3 RASS Webinars…….…………………………...………11 RASS Award Winners ………………………. ………4 Incoming Officers ………………………………………11 Top Ten Meeting Abstracts ……………………..…….5 Recent Risk Assessment Survey…….…………….…….12 Best Risk Assessment Papers of 2012 ………………..8 Training Opportunities……………………………….….12 Annual Meeting Seccions Endorsed …………….…..10

March 12 at 6:00 pm in the Grand Hyatt Hotel, Texas Ballroom D. All winners have been notified and those making poster presentations have been invited to display their work during the RASS reception. Since we did all this work to shift deadlines forward and since we imposed on several highly sought-after individuals as judges and then hounded them relentlessly for results (they were each very gracious, too!)– the results are also going to be available on the RASS poster. The poster will be up during the

RASS Newsletter

Much of the content of this RASS Newsletter is geared toward the Annual Meeting.

Cont’d on p. 2

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President’s Message, Cont’d Tox Expo in the exhibition hall – please check it out! This poster will be displayed at the Graduate

Student/Post Doctoral reception Sunday evening, and it will also be displayed at our RASS reception. Special thanks go out to Laurie Haws, John DeSesso and all the judges. Way to go! And, speaking of the reception … last year RASS polled our membership regarding the desire for a scientific presentation during our reception, or simply unstructured time to mix and mingle. We announced the results at the reception last year, which was, a roughly 48/52% split. Last year, we had a short program on EPA’s IRIS program. This year, we have worked with the Regulatory and Safety Evaluation Specialty Section (Paul Brown, President) to join them for their Great Debate, which will begin at 7:00 p.m. Tuesday in Texas ballroom A. RSESS has invited any and all RASS members to come enjoy this lighthearted examination of non monotonic dose response issues. RASS has begun an outreach program to increase our membership, which will allow us to continue and expand the services we offer to our members. Recently, a new initiative has been undertaken by the SOT Membership Committee (Co Chaired by our own Michael Dourson!) and the Specialty Section Collaboration and Communication Workgroup (Co-Chaired by yours truly). These groups have worked together to develop a new activity that asks individuals applying for SOT membership to identify specialty areas of toxicology in which they are interested. Once these new members are admitted, their names are forwarded to the respective Specialty Sections. RASS has already sent targeted mailings to fourteen individuals from the fall 2012 class of members (Full, Associate, Post Doctoral and Student members) and has plans to repeat the activity for the January 2013 class of new members. It is yet too early to tell how this will work out, but we are hopeful. Out of a membership of over 700, RASS has about 40 student and post doc members. We should increase that number, so that we can make opportunities to let those young people know about risk assessment, what we do, and how their technical skills and knowledge base can (and do) fit into our daily work. We have begun to offer free membership to students and post docs who apply for our named awards. If any of you work with graduate students or post docs, please encourage them to join our ranks, so that they can take part in our activities. Under the guidance of our Post Doctoral Representative, Roxana Weil and our Graduate Student Representative, Jose Torres, RASS has conducted some activities that will be useful in informing Students and Post Docs about risk assessment and RASS. Jose suggested and took the lead in administering a survey to many established risk assessors to summarize a listing of skill sets looked for in individuals wishing to pursue careers in risk assessment. Something new and likely catchy for this year is a bookmark developed by Roxana, which contains information on award winners, reception details, sponsored sessions, etc. in a QR linked format. This will be handed out Sunday evening at the PDA/GSLA reception. And I bet it will generate a lot of new interest in RASS. Did you know that under the leadership of Annie Jarabek, RASS develops and sponsors ten webinars on risk assessment topics each year? These (slides and audio) are archived on the web for later viewing, which will come in handy for those of you needing CE credits through the year, or who want to browse the list and add to your knowledge base. Details on the webinars and several other on-site courses and meetings can be found further below in this newsletter. If you have webinar topics to suggest, please let Annie know. You recently received a link to a survey conducted by George Mason University and Harris Polls. If you did not, please check your Spam filters for a message on February 13 from “[rass.annc]JohnMDeSesso”. The response rate has been low and we need to hear back from you, please. More details on the survey can be found in this issue of the newsletter. Cont’d on p. 3

RASS, March, 2013

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President’s Message, Cont’d

The RASS mixer will be held in the Grand Hyatt Texas Ballroom D on Tuesday, March 12, from 6:00 until 7:30 pm. RASS will present awards and required business information at the beginning, followed by time for socializing. RASS and the Regulatory and Safety Evaluation Specialty Section are teaming up to present the Great Debate, which will be held in Texas Ballroom A from 7:00 until 7:30. Those interested can take the short walk over to this lighthearted foray into the controversial topic of low dose extrapolation.

RASS Mixer and The Great Debate (RSESS)

At present, we have had only about one hundred responses from RASS’ membership of over 700. We need to improve that. The survey didn’t happen by itself. GMU contacted SOT to ask if they could survey RASS, and SOT sent the request to us. Because I was COI’d out, given that GMU wanted to use the results to lobby for changes in risk assessment policies, including those administered by the U.S. government, John DeSesso, with input from Laurie Haws, had a long and in depth interaction with the survey’s developer to improve and expand the survey. This was real work, undertaken in a thoughtful manner. The results will be statistically analyzed by Harris Polls, John has negotiated a spot on the group that will evaluate and develop the report-out on survey results, which may include publication in the peer reviewed literature. Once they had the survey revised, GMU also sent the survey request to members of the Society for Risk Analysis. We will make sure to disseminate the findings when they are available. Finally, I want to thank each and every one of you for your support of RASS. RASS is the second largest Specialty Section in our Society - and, because of members like you, we are energetic, organized, productive, effective and fun. I never thought I would have the opportunity to work with such a bunch of people each of which are absolutely top-flight. John C. Lipscomb, PhD, DABT, ATS President Risk Assessment Specialty Section

First presented in 1980, the Arnold J. Lehman Award recognizes an individual who has made a major contribution to risk assessment and/or the regulation of chemical agents. Congratulations to Dr Moiz Mumtaz upon being selected recipient of the 2013 Arnold Lehman Award. Moiz’ tireless work over the past 25 years has focused on development of risk assessment methods with an emphasis on chemical mixtures and cumulative risk assessment. The award will be presented during the Awards Ceremony, Sunday at 5:15 p.m. in the Convention Center, Grand Ballroom C1.

Arnold Lehman Award Winner, Dr Moiz Mumtaz

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SOT’s Endowment Funds and Risk Assessment Specialty Section Award Winners for 2013

The Rubin, Doull and Gehring Awards are made possible through SOT’s Endowment funds. RASS and the award recipients gratefully acknowledge those contributions and ask that you consider making a small contribution to the Endowment Funds. Visit http://www.toxicology.org/AI/CSOT/contribute.asp or call SOT at 703 438 3115 to make your arrangements. Each year, RASS evaluates abstracts accepted for presentation at the annual meeting. Named awards funded by the Endowment fund account for four awards presented to students or post docs. RASS recognizes these winners with a $500 check from the Endowment Fund and plaque, and their advisors each receive a plaque. The final abstract award is not restricted by membership type and is presented for the meeting’s Overall Best Risk Assessment Abstract. RASS presents the lead author of the Best Overall Abstract with a plaque. RASS is grateful to these SOT members for serving as abstract judges: John DeSesso (Chair), John Lipscomb, Ivan Boyer, Cecilia Tan, David Saltmiras, Dave Eaton (Mechanisms SS), Terry Kavanagh (Mechanisms SS). For more information on RASS awards including deadline and point of contact, please consult the RASS home page.

John Doull Award, Rachel Church (right)

Rachel J. Church, D.M. Gatti, J.S. Eaddy, P.B. Watkins, D.W. Threadgill and A.H. Harrill. The Hamner – UNC Institute for Drug Safety Sciences, Jackson Laboratories and North Carolina State University. Identification of Genomic Regions Linked to Epigallochatechin Gallate Induced Liver Toxicity using the Diversity Outbred Stock. Abstract 183, Board 342 in Pharmacogenomics and Genetic Polymorphisms Poster Session, Monday, March 11, 9:30 a.m. until 12:30 p.m.

Robert J. Rubin Award, Xiao Pan (left)

Xiao Pan, C. A. Whitten, M. Wu, C. Chan, C. G. Wilkerson, J. J. Pestka. Michigan State University, East Lansing, Michigan. Quantitative phosphoproteomic analysis of the dynamic signaling network mediating proinflammatory response in the spleen of mice under deoxynivalenol-induced ribotoxic stress. Abstract 2079, Board 138 in Immunotoxicity—Biochemical/Molecular Poster Session, Wednesday, March 13, 1:00 p.m. until 4:30 p.m. Cont’d on p. 5

RASS, March, 2013

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Award Winners, Cont’d

“Top Ten” Meeting Abstracts

Perry J. Gehring Best Post Doctoral Student, Merrie Mosedale (right)

Merrie Mosedale, C. Lisa Kurtz, J. Scott Eaddy, Karissa Adkins, Hong

Wu, Paul B. Watkins, and Alison Harrill. The Hamner Institutes for Health Sciences, Pfizer, Inc., and The University of North Carolina at Chapel Hill. Safety Assessment of a Novel Antibiotic Using a Mouse Population-Based Approach Predicts Risk of DILI in Humans Where Classical Models Fail. Abstract 716, Board 591 in Risk Assessment I: Advances in Approaches and Technologies Poster Session. Monday,

March 11, 1:00 pm until 4:30 pm.

Perry J. Gehring Best Graduate Student, Virunya S. Bhat (left)

Virunya Bhat, Susan Hester, Steve Nesnow, and David Eastmond. UC Riverside and U. S. EPA. Concordance of Transcriptional and Apical Benchmark Dose Levels for Conazole-Induced Liver Effects in Mice.

Abstract 1946, Board 536 in Risk Assessment II: Critical Considerations and Characterizations Poster Session. Wednesday, March 13, 9:00 a.m.

until 12:30 p.m.

Best Abstract Robyn Prueitt, Julie Goodman, and Lorenz Rhomberg. Gradient

Corporation. Hypothesis-Based Weight-of-Evidence Evaluation of the Human Carcinogenicity of Toluene Diisocyanate. Abstract 1951, Board 541 in Risk Assessment II: Critical Considerations and Characterizations

Poster Session. Wednesday, March 13, 9:00 a.m. until 12:30 p.m.  

Authors: Christopher Kirman, Summit Toxicology LLP, Orange, OH Mark A Harris, ToxStrategies, Katy, TX Laurie C. Haws, ToxStrategies, Austin, TX Sean M. Hays, Summit Toxicology LLP, Allenspark, CO Deborah M. Proctor, ToxStrategies, Rancho Santa Margarita, CA Mina Suh, ToxStrategies, Rancho Santa Margarita, CA Chad M. Thompson, ToxStrategies, Katy, TX Title: Using PBPK Modeling to Address Diurnal Variation and Age Differences

in Hexavalent Chromium Toxicokinetics in Humans Abstract#: 517 Poster Board - 335 Session Title: Pharmacokinetics and Disposition Session Date: Monday, March 11, 2013 Session Time: 1:00 PM Cont’d on p. 6

Click here for full text of all Best Abstracts

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“Top Ten” Meeting Abstracts, Cont’d Authors: Merrie Mosedale, The Hammer Institutes for Health Sciences, Research Triangle Park, NC Karissa Adkins, Pfizer, Inc., Groton, CT J. Scott Eaddy, The Hammer Institutes for Health Sciences, Research Triangle Park, NC Alison H. Harrill, The Hammer Institutes for Health Sciences, Research Triangle Park, NC; The

University of North Carolina at Chapel Hill, Chapel Hill, NC C. Lisa Kurtz, The Hammer Institutes for Health Sciences, Research Triangle Park, NC Paul B. Watkins, The Hammer Institutes for Health Sciences, Research Triangle Park, NC; The

University of North Carolina at Chapel Hill, Chapel Hill, NC Hong Wu, Pfizer, Inc., Groton, CT Title: Safety Assessment of a Novel Antibiotic Using a Mouse Population-Based Approach Predicts Risk of

DILI in Humans Where Classical Models Fail Abstract#: 716 Poster Board - 591 Session Title: Risk Assessment I: Advances in Approaches and Technologies Session Date: Monday, March 11, 2013 Session Time: 1:00 PM PERRY J. GEHRING STUDENT AWARD WINNER Authors: Sesha Hanson-Drury, Systems Toxicology and Exposure Science, Pacific Northwest National

Laboratory, Richland, WA Justin G. Teeguarden, Systems Toxicology and Exposure Science, Pacific Northwest National

Laboratory, Richland, WA Title: Systematic Review of BPA “Low Dose” Literature in the Context of Human Dosimetry Exposes a

Need to Set Standards for Responsible Communication of Both Toxicity and Exposure Data Abstract#: 1261 Poster Board - 223 Session Title: Exposure Assessment: New Characterizations, Methods, and Models Session Date: Tuesday, March 12, 2013 Session Time: 1:00 PM Authors: Donatello Telesca, Biostatistics, University of California Los Angeles, Los Angeles, CA Justin G. Teeguarden, Biological Sciences, Pacific Northwest National Laboratory, Richland, WA Andre Nel, Nanomedicine, California Nanosystems Institute, University of California Los Angeles,

Los Angeles, CA Joel G. Pounds, Biological Sciences, Pacific Northwest National Laboratory, Richland, WA Brian D. Thrall, Biological Sciences, Pacific Northwest National Laboratory, Richland, WA Tian Xia, Nanomedicine, California Nanosystems Institute, University of California Los Angeles, Los

Angeles, CA Haiyuan Zhang, Nanomedicine, California Nanosystems Institute, University of California Los

Angeles, Los Angeles, CA Title: Computational Dosimetry Driven Hazard Ranking of 25 Metal Oxide Nanomaterials Using Low- and

High-Throughput In Vitro Toxicity Data Abstract#: 1734 Poster Board - 201 Session Title: Nanotoxicology—In Vitro Session Date: Wednesday, March 13, 2013 Session Time: 9:00 AM Authors: Joanne Wan, Intertek Cantox, Mississauga, ON, Canada Jeffrey W. Card, Intertek Cantox, Mississauga, ON, Canada Hanna Fikree, Intertek Cantox, Mississauga, ON, Canada Lois Haughton, Intertek Cantox, Mississauga, ON, Canada Valentia Lee-Brotherton, Intertek Cantox, Mississauga, ON, Canada Bart Sangster, ASAT Foundation, Leidschendam, Netherlands Title: Evaluation of Tumor Pathology Concordance Between Epidemiological and Rodent Studies Abstract#: 1943 Poster Board - 533 Session Title: Risk Assessment II: Critical Considerations and Characterizations Session Date: Wednesday, March 13, 2013 Session Time: 9:00 AM Authors: Virunya S. Bhat*†, Environmental Toxicology, University of California Riverside, Riverside, CA D. A. Eastmond, Environmental Toxicology, University of California Riverside, Riverside, CA Susan Hester, NHEERL, US EPA, Research Triangle Park, NC S. Nesnow, NHEERL, US EPA, Research Triangle Park, NC Title: Concordance of Transcriptional and Apical Benchmark Dose Levels for Conazole-Induced Liver

Effects in Mice

Cont’d on p. 7

RASS, March, 2013

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“Top Ten” Meeting Abstracts, Cont’d

Authors: Virunya S. Bhat, Environmental Toxicology, University of California Riverside, Riverside, CA D. A. Eastmond, Environmental Toxicology, University of California Riverside, Riverside, CA Susan Hester, NHEERL, US EPA, Research Triangle Park, NC S. Nesnow, NHEERL, US EPA, Research Triangle Park, NC Title: Concordance of Transcriptional and Apical Benchmark Dose Levels for Conazole-Induced Liver

Effects in Mice Abstract#: 1946 Poster Board - 536 Session Title: Risk Assessment II: Critical Considerations and Characterizations Session Date: Wednesday, March 13, 2013 Session Time: 9:00 AM PERRY J. GEHRING POSTDOCTORAL AWARD WINNER Authors: Lynne T. Haber, Toxicology Excellence for Risk Assessment (TERA), Cincinnati, OH B. Bhaskar Gollapudi, Toxicology & Environmental Research and Consulting, Dow Chemical

Company, Midland, MI Matthew J. LeBaron, Toxicology & Environmental Research and Consulting, Dow Chemical

Company, Midland, MI Mugimane G. Manjanatha, Division of Genetic and Molecular Toxicology, National Center for

Toxicological Research, US FDA, Jefferson, AR Martha M. Moore, Division of Genetic and Molecular Toxicology, National Center for Toxicological

Research, US FDA, Jefferson, AR Nigel P. Moore, Dow Europe GmbH, Horgen, Switzerland Barbara L. Parsons, Division of Genetic and Molecular Toxicology, National Center for Toxicological

Research, US FDA, Jefferson, AR Title: Mode-of-Action Evaluation for Lung Tumors in Mice Exposed to Ethylene Oxide via Inhalation Abstract#: 1969 Poster Board - 559 Session Title: Risk Assessment II: Critical Considerations and Characterizations Session Date: Wednesday, March 13, 2013 Session Time: 9:00 AM Authors: Robinan Gentry, ENVIRON International Corporation, West Monroe, LA Pergentino Balbuena, The Hamner Institutes for Health Sciences, Research Triangle Park, NC Michael B. Black, The Hamner Institutes for Health Sciences, Research Triangle Park, NC Harvey J. Clewell, The Hamner Institutes for Health Sciences, Research Triangle Park, NC Alina Efremenko, The Hamner Institutes for Health Sciences, Research Triangle Park, NC Janice W. Yager, University of New Mexico, Albuquerque, NM Title: Advancements in Arsenic Research Suggest a Dose-Dependent Transition Concentration for Cancer

Endpoints Abstract#: 1979 Poster Board - 569 Session Title: Risk Assessment II: Critical Considerations and Characterizations Session Date: Wednesday, March 13, 2013 Session Time: 9:00 AM Authors: Rachel E. Peters, University of Saskatchewan, Saskatoon, SK, Canada Scott Clemow, SNC-Lavalin Environment, Ottawa, ON, Canada Kyle James, University of Saskatchewan, Saskatoon, SK, Canada Mark Richardson, Stantec Consulting Ltd., Ottawa, ON, Canada Steven D. Siciliano, University of Saskatchewan, Saskatoon, SK, Canada Title: Assessment of Risks to the US Population Posed by Exposure to Gold and Ceramic Dental

Restorations Abstract#: 2220 Poster Board - 418 Session Title: Risk Assessment III: New Derivations and Updated Estimates Session Date: Wednesday, March 13, 2013 Session Time: 1:00 PM

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Each year, RASS evaluates papers published hardcopy or on line to identify the Best Risk Assessment Papers for each of two categories: Application of Risk Assessment and Advancing the Science of Risk Assessment. These papers are identified from literature searches and from nominations which we solicit from our membership. The lead authors of the most outstanding papers in each category receive a plaque and $250 check. RASS is grateful to Environ International Corporation for sponsoring these awards. A debt of gratitude is also owed to the judges who worked tirelessly to evaluate the papers: Laurie Haws (Chair), John Lipscomb, Michael DeVito, Laura Plunkett and Nancy Beck.

Best Papers Demonstrating an Application of Risk Assessment

Outstanding Paper Criswell KA, Cook JC, Wojcinski Z, Pegg D, Herman J, Wesche D, Giddings J, Brady J, Anderson T. Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance. Toxicol Sci. 2012. 128(1):57–71.

Best Papers Bailey LA, Prueitt R, Rhomberg L. Hypothesis-Based Weight-of-Evidence evaluation of methanol as a human carcinogen. Regul Toxicol Pharmacol. 2012. 62(2):278–291. Bourdon JA, Williams A, Kuo B, Moffat I, White P, et al. Gene expression profiling to identify potentially relevant disease outcomes and support human health risk assessment for carbon black nanoparticle exposure. Toxicology. 2012. 303C:83–93. Hays S M, Pyatt DW, Kirman CR, Aylward LL. Biomonitoring Equivalents for benzene. Regul Toxicol Pharmacol. 2012. 62(1):62–73. Kirman CR, Hays SM, Aylward LL, Suh M, Harris MA, Thompson CM, Haws LC, Proctor DM. Physiologically-based pharmacokinetic model for rats and mice orally exposed to chromium. Chem Biol Interact. 2012. 200:45–64. Kopec AK, Kim S, Forgacs AL, Zacharewski TR, Proctor DM, Harris MA, Haws LC, Thompson CM. Genome-wide expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water. Toxicol Appl Pharmacol. 2012. 259:13–26. Kopec AK, Thompson CM, Kim S, Forgacs AL, Zacharewski TR. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestine epithelia. Toxicol Appl Pharmacol. 2012. 262:124–138. Schroeter J D, Dorman DC, Yoon M, Nong A, Taylor MD, et al. Application of a multi-route physiologically based pharmacokinetic model for manganese to evaluate dose-dependent neurological effects in monkeys. Toxicol Sci. 2012. 129(2):432–446. Thomas R S, Himmelstein MW, Clewell HJ 3rd, Yang Y, Healy E, et al. Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene. Toxicol Sci. doi:10.1093/toxsci/kfs.314, Nov 3, 2012. 131(2):629–640. Thompson CM, Proctor DM, Suh M, Haws LC, Hebert CD, Mann JF, Shertzer HG, Hixon G, Harris MA. Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: Implications for carcinogenic modes of action. Tox Sci. 2012. 125(1):79–90.

Best Papers, 2012

Cont’d on p. 8

RASS, March, 2013

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Best Papers, 2012, Cont’d Best Papers Advancing the Science of Risk Assessment

Outstanding Paper

Bars RI, Fegert M, Gross D, Lewis L, Weltje E, Weyers A, Wheeler JR, Galay-Burgos M. Risk assessment of endocrine active chemicals: identifying chemicals of regulatory concern. Regul Toxicol Pharmacol. 2012. 64(1):143–154.

Best Papers Creton S, Saghir S, Bartels M, Billington R, Bus J, et al. Use of toxicokinetics to support chemical evaluation: Informing high dose selection and study interpretation. Regul Toxicol Pharmacol. 2012. 62(2):241–247. Gollapudi B, Johnson G, Hernandez L, Pottenger L, Dearfield K, et al. Quantitative approaches for assessing dose-response relationships in genetic toxicology studies. Environ Mol Mutagen. 2012. 54(1). Lock E, Abdo N, Huang R, Xia M, Kosyk O, et al. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicol Sci. 2012. 126(2):574–588. Lavelle KS, Schnatter A, Travis K, Swaen G, Pallapies D, et al. Framework for integrating human and animal data in chemical risk assessment. Regul Toxicol Pharmacol. 2012. 62(2):302–312. Najita J, Catalano P. On Determining the BMD from Multiple Outcomes in Developmental Toxicity Studies when One Outcome is Intentionally Missing. Risk Anal. Dec 12, 2012. doi: 10.1111/j.1539-6924.2012.01939.x. Roos V, Gunnarsson L, Fick J, Larsson D, Ruden C. Prioritising pharmaceuticals for environmental risk assessment: Towards adequate and feasible first-tier selection. Sci Total Environ. 2012. 421–422:102–110. Selck H, Drouillard K, Eisenreich K, Koelmans A, Palmqvist A, et al. Explaining differences between bioaccumulation measurements in laboratory and field data through use of a probabilistic modeling approach. Integr Environ Assess Manag. 2012. 8(1):42–63. Thomas R, Clewell H 3rd, Allen B, Yang L, Healy E, et al. Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: a five chemical case study. Mutat Res. 2012. 746(2):135–143. Thompson D, Beard D. Physiologically based pharmacokinetic tissue compartment model selection in drug development and risk assessment. J Pharm Sci. 2012. 101(1):424–435.

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Monday,  March  11  

Symposium   Translatable  Indicators  of  Testicular  Toxicity:  Inhibin  B,  MicroRNAs,  and  Sperm  Signatures  

9:15  am  to  12:00  pm  Room  214,  C&D  

Workshop   Biology  of  Low  Dose  Response  for  DNA-­‐Reactive  Chemicals   9:15  am  to  12:00  pm  Room  217  A&B  

Workshop   Life-­‐Course  Models  for  Ensuring  Children’s  Health  Protection  

2:00  pm  to  4:45  pm  Room  214  A&B  

Workshop   Scientific  and  Regulatory  Advances  in  Genetic  Toxicology  Safety  Assessment  

2:00  pm  to  4:45  pm  Room  214  C&D  

Historical  Highlight   Diesel  and  Gasoline  Exhaust  and  Cancer   12:10  pm  to  1:30  pm  Room  206  

Tuesday,  March  12  Workshop   Advances  in  Carcinogenic  Risk  Assessment  of  Low-­‐level  

Genotoxic  Impurities  in  Pharmaceuticals  9:00  am  to  11:45  pm  Room  206  

Wednesday,  March  13  Symposium   Toxicoepigenomics,  Disease  Susceptibility,  and  Implications  

for  Risk  Assessment  9:00  am  to  11:45  pm  Grand  Ballroom  C3  

Workshop   Toxicogenomics  in  Risk  and  Safety  Assessment:  Recent  Advances  and  Continuing  Challenges  

1:30  pm  to  4:15  pm  Room  217  C&D  

Informational  Session   Regulatory-­‐Based  Nanotoxicology:  Evolving  National  Strategies  and  Research  to  Address  Engineered  Nanomaterial  Health  Risk  Assessments  

4:30  pm  to  5:50  pm  Room  217  A&B  

Education-­‐Career  Development  Session  

Regulatory  Science  and  Risk  Assessment:  Lessons  for  Early-­‐Career  Scientists  on  What  to  Expect  and  How  to  Pursue  This  Career  Path  

12:00  pm  to  1:20  pm  Room  214  C&D  

Education-­‐Career  Development  Session  

Toxicological  Writing  for  Industrial  and  Regulatory  Audiences  

4:30  pm  to  5:50  pm  Room  214  C&D  

Regional  Interest  Session  

Assessment  of  Environmental,  Dietary,  and  Biological  Risk  Factors  Impacting  Liver  cancer  Incidence  in  Texas  

1:30  pm  to  4:15  pm  Grand  Ballroom  C2  

Thursday,  March  14  Symposium   Modeling  Human  Genetic  Variability  and  Susceptibility  in  

the  Laboratory    9:00  am  to  11:45  pm  Room  217  C&D  

Workshop   Cumulative  Risk:  Toxicity  and  Interactions  of  Physical  and  Chemical  Stressors  

9:00  am  to  11:45  pm  Room  217  A&B  

Annual Meeting Sessions Endorsed Each year, RASS is asked to evaluate Sessions proposed for inclusion in the Annual meeting.

The Scientific program Committee performs their own evaluation, which relies heavily on comments from Specialty Sections. This input is critical, and comments from the Specialty Sections are given heavy consideration. This year, three Continuing Education Courses and fourteen sessions (below) that were either sponsored or endorsed by RASS were selected for presentation. Please consider attending these, if possible.

Session Proposals for 2014 are Due April 30, 2013 RASS members are encouraged to draft proposals for sessions (Workshops, Symposia, Roundtables, CE Workshops) for presentation at the 2014 Annual Meeting in Phoenix. The SOT HQ deadline for submission of proposals to the Program Committee is April 30, 2013 and it is requested that all proposals be submitted to the RASS Vice President, Laurie Haws for RASS preview and comments soon so there is sufficient time for evaluation and feedback so that proposals may be revised prior to submission.

RASS, March, 2013

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During the past year, RASS has continued hosting our webinars. These occur monthly except in March and July, at 3 pm eastern time on the second Tuesday of the month. We are grateful to Annie Jarabek for her tireless efforts in soliciting ideas, making proposals, coordinating and hosting these informative sessions. Although the 2013 schedule is complete, please send her your ideas for topics of interest. Each of these webinars is archived on the RASS webpage. If you miss one, they can be played back from http://www.toxicology.org/ISOT/SS/RiskAssess/downloads.asp. RASS members receive an email notification for that event. Upcoming webinars include:

• Health Effects of Multipollutant Airsheds. Jack Harkema, Michigan State University. Tuesday, April 10, 2013, 3 p.m. eastern

• Panel Discussion on Nonmonotonic Dose Response. Scott Belcher, Ed Calabrese,

Rory Conolly, Earl Gray, Tom Zoeller. Tuesday, May 14, 3:00 p.m. eastern

• Cumulative Risk Assessment. Glenn Rice and Amanda Evans, U.S. EPA/ORD/NCEA-Cincinnati Tuesday, June 12, 3:00 p.m. eastern

RASS Webinars

Incoming RASS Officers RASS wants to thank all those that offered or were volunteered to run for office. We welcome the following new officers for the 2013-2014; their terms will begin May 1.

Vice President-Elect Hugh A. Barton (right) Pfizer, Groton, CT

We give special thanks to our outgoing officers: Robinan Gentry, Past President; Elaina Kenyon, Secretary-Treasurer; Bob Budinsky, Councilor; and Roxana Weil, Post Doctoral Representative.

Secretary-Treasurer George Woodall U.S. EPA, RTP, NC

Councilor Anna B. Lowit U.S. EPA, Arlington, VA,

Post Doctoral Representative Michelle DeSimone North Carolina State University, Raleigh, NC

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Risk Assessment Training Opportunities

TERA DOSE-RESPONSE BOOT CAMP Registration  is  now  open!    TERA’s  Dose-­‐Response  Assessment  Boot  Camp  course  will  be  held  May  6-­‐10,  2013  in  Cincinnati,  Ohio.    You  may  register  online  at  http://www.tera.org/Global/Bootcamp/registration.html.        This  course  is  a  5-­‐day  intensive  hands-­‐on  training  in  hazard  characterization  and  dose-­‐response  assessment.  Beginners  through  expert  toxicological  risk  assessors  will  learn  advanced  methods,  as  well  as  enhance  their  understanding  and  skills  in  the  basics.  Course  lectures  are  supplemented  with  daily  hands-­‐on  application  exercises.      Course  registration  is  $2100  (Federal  Agency,  Industry,  University,  etc)    and  $1600  (State/Local/Tribal  Agencies).    If  you  register  after  March  31,  2013  the  late  registration  fee  is  $2300  /  $1800,  respectively.   The  course  will  be  held  in  Cincinnati,  Ohio  at  the  Mariemont  Inn.    It  is  located  6880  Wooster  Pike,  Cincinnati,  OH.  The  course  runs  from  8:00am-­‐5:00pm  Monday-­‐Thursday,  and  8:00am-­‐2:00pm  Friday.    A  block  of  rooms  under  "TERA  Group"  is  being  held  for  all  attendees.  You  must  make  your  hotel  reservation  no  later  than  Friday,  April  5th  to  get  the  group  rate.  The  cost  per  room  is  $143.65  +tax/night,  which  includes  a  complimentary  bottled  water  and  gourmet  snacks  at  check-­‐in.  If  you  need  the  government  per  diem  rate,  just  mention  that  when  you  call  to  make  your  reservations.  For  reservations  call  513-­‐271-­‐2100.    

In addition to the offerings below, please also consider the value in attending our RASS Webinars. These moderated sessions are recorded and archived on the web. We have some excellent sessions coming soon. Look on page 11, this newsletter edition, for more details. Just another great benefit included with your RASS membership!

RASS MONTHLY WEBINARS

On occasion, RASS is asked to disseminate information to our members which is timely and of potential interest to them. Here are some training opportunities that you or your friends may be interested in. The broadcast of this information does not imply RASS endorsement or sponsorship – except for the Webinars, which we, of course, think are totally awesome.

On February 13 SOT headquarters sent a survey to the RASS membership under John DeSesso’s signature, [rass.annc]JohnM.DeSesso. The survey was initially designed by Dr. Robert Lichter of George Mason University to capture the collective wisdom of knowledgeable scientific experts with regard to the role of risk assessment in government regulatory decisions. Many of you may have missed the invitation because it may have been filtered out by your junk filters (an unfortunate consequence of being sent to you as part of a mass mailing). The survey is being administered by the Harris Group. All responses are anonymous and so far we have only about 100 respondents from RASS’ membership of over 700. Won’t you please search for it and complete it; if you can’t find it, please get in touch with John DeSesso (JDeSesso@exponent.com). Once complete, the results of the survey will be available to RASS and will be presented in scientific forums. RASS Council urges you to look for the survey in your inbox or junk filters and invest 10 minute of you day to complete the survey. Your efforts will help to shore up the scientific underpinnings of risk-based decisions in the government.

Recent Risk Assessment Survey

RASS, March, 2013

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Risk Assessment Training Opportunities, Cont’d

2013 Toxicology and Risk Assessment Conference

April 8-11, 2013

Cincinnati, Ohio, USA

http://www.cdc.gov/niosh/conferences/TRAC/default.html The 2013 Toxicology and Risk Assessment Conference (TRAC) will be a 4-day meeting focusing on topics in risk assessment principles and practice. The conference provides attendees with an overview of current research, methodologic, and practice issues that are the focus of risk assessment efforts in various Federal agencies, academic institutions, industry, and other organizations. The theme of TRAC 2013 is “Toxicology and Risk Assessment Guidance: From Principles to Practice in the Age of Omics, Osomes, and New Opportunities.” This theme will examine the -omics fields, such as toxicogenomics, proteomics, and metabolomics, components of the concept of the exposome, and other emerging technologies, for current state-of-the-science opportunities for setting guidance and exposure limits. The Plenary session, on the first day of the main conference, and specific workshops on risk assessment methodologies held on the days before and after the two main conference days, comprise TRAC 2013. Conference registration and a preliminary agenda are available at http://www.cdc.gov/niosh/conferences/TRAC/default.html. Registration cost for the two main conference days, April 9-10, 2013, is $250. Other levels of registration fees are available. Workshops have separate registration fees as described on the conference website. Also featured is a poster session on the evening of April 9, 2013, with a trainee competition, for which the poster abstract deadline is March 30, 2013. The poster session is designed to provide participants the opportunity to share their work in a focused, collegial environment. We invite poster abstract submissions of broad interest to toxicology and risk assessment. Further, we invite work that has been submitted in the previous year at other relevant conferences to stimulate discussion in the more focused environment of TRAC. Please visit http://www.cdc.gov/niosh/conferences/TRAC/default.html for further details. Continuing education for this activity is pending. See final announcement for details. This activity has been approved by the American Board of Preventive Medicine for LLSA/MOC credit. See final announcement for details.

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Risk Assessment Training Opportunities, Cont’d

Analyzing Risk: Principles, Concepts, and Applications March 11 – 14, 2013 | Boston, MA https://ecpe.sph.harvard.edu/Risk-Analysis Participants learn how to apply the science behind risk-based decision making, examine complex problems involving chemicals, radiation, and other hazards in the environment, discuss emerging analytic approaches, and review important issues with leaders in the field. This program provides education on current risk analysis methods from a variety of backgrounds, but with a common interest in understanding how risk analysis is done, how it is interpreted, and how it influences regulatory decision making. Learning Objectives:

• Examine current and emerging methods for quantifying risks • Evaluate exposure assessment protocols • Differentiate between key assumptions and uncertainties in non-cancer and cancer dose-

response models • Implement probabilistic methods in uncertainty analysis and risk assessment • Identify key factors that influence risk perception and communication • Evaluate alternative approaches for valuation of environmental health risk outcomes • Understand the role of risk information in benefit-cost analysis and risk management

Effective Risk Communication: Theory, Tools, and Practical Skills for Communicating about Risk March 18 – 20, 2013 | Boston, MA https://ecpe.sph.harvard.edu/Risk-Communication This introductory program explores the scientific foundations for effective risk communication. Participants will gain the skills necessary to communicate about risk to various audiences by working with different perspectives and encouraging more reasoned behavior among the people they are trying to influence and serve. Learning Objectives

• Understand the key components that make up risk perception, the values and concerns brought by various audiences, and likely responses of these audiences to such risk issues as new technologies, facility siting, and new regulations

• Develop strategies to enhance understanding and trust amongst audiences while minimizing conflict on risk issues

• Craft organizational policies and messages responsive to audience risk concern

Harvard Center for Risk Analysis