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R. Venema Lab Our research focuses on the molecular and cellular regulation of the endothelial nitric oxide synthase, widely held to be a very important enzyme in blood pressure control and in preventing the development of atherosclerosis. Lab members: Richard C. Venema, Ph.D, Professor - PowerPoint PPT Presentation
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NO• in blood vesselsacetylcholinebradykininthrombinincreased flow (shear)
Ca2+ + CaM
eNOSarginine + O2 citrulline + NO •
NO •
Fe
GTP cGMP
relaxation
guanylatecyclase
SMOOTH MUSCLE CELL
ENDOTHELIAL CELL
NO • Inhibition of
platelet aggregation
leukocyte adhesion
vascular smooth muscle proliferation
vascular lesion formation(atherosclerosis)
vesseldilation
R. Venema Lab
Our research focuses on the molecular and cellular regulation of the endothelial nitric oxide synthase, widely held to be a very important enzyme in blood pressure control and in preventing the development of atherosclerosis.
Lab members:
Richard C. Venema, Ph.D, Professor
Chunying Li, Ph.D., Postdoctoral Fellow
Sarika G. Sood, M.D., Research Associate
Ling Ruan, M.S., Research Associate
Virginia J. Venema, M.S., Research Assistant
Publications: Go to www.pubmed.gov, enter venema rGrant Support: National Institutes of Health and American Heart Association
