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7/23/2019 Ppt Penatalaksanaan Parkinson's Disease http://slidepdf.com/reader/full/ppt-penatalaksanaan-parkinsons-disease 1/23 REFERAT PENATALAKSANAAN PARKINSON’S DISEASE Putri Nisrina Hamdan 1102011213 Pembimbin! dr. M. Tri Wahyu Sp. S, M. Kes 

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REFERATPENATALAKSANAAN

PARKINSON’S DISEASE

Putri Nisrina Hamdan

1102011213

Pembimbin!dr. M. Tri Wahyu Sp. S, M. Kes 

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PARKINSON’S DISEASE

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Par"is#nisme  Sindr#m  trem#r$a"tu istira%at& riiditas& bra"inesia&dan %i'ann(a re)e* +#stura'  "adard#+amine,

Pen(a"it Par"ins#n deenerasian'ia basa'is terutama disubstansia nira +ars "#m+a"ta  adan(a in"'usi sit#+'asma eusin#-'disebut denan Le$( .#dies,

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Eti#'#i

/siaFa"t#reneti

"

Fa"t#rLin"un

an

 TraumaKe+a'a

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ETIOPATOFISIOLOGIStr!e

As"!sia#ip$%i!e&ia

Sia'ida, (O, MPTP

Ga'$$ua'&eta)%is&e

'eur'

Me!a'is&ee*+itt*i+i

ty

O*idatie stress

APOPTOSIS NEKSROSIS

DEGENERASI S-STANSIA NIGRA

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Kerusa"an +ada substansia nira SN,

 Tan+a d#+amin& sin(a' tida" da+atdisam+ai"an dari SN "e baian 'ain di

#ta", Semua unsi neur#n di SSPmenurun,

Kadar d#+amin menurun,

kelambatan gerak (bradikinesia),

kelambatan bicara dan berpikir

(bradifrenia), tremor dan kekauan

(rigiditas).

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GE/ALA KLINIS

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PEMERIKSAAN PEN-N/ANG

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DIAGNOSIS

P!di Me&e't Disrders PERDOSSI

Kriteria K%i'is

Kriteria K%%er

Kriteria #u$hes

• P#ssib'e ! 1 dari 3e4a'a utama

• Pr#bab'e! ada 2dari 5 e4a'am#t#ri"

De-nite! ada 3e4a'a utama

Ada 3 ma6am dian#sis se+erti "riteria %u%es• De-nit ada tanda "riteria dian#sis +#ssib'e dan "#n-rmasi %ist#+at#'#i

Kriteria Ge%) da'%a0a'ya

Dida+at"an 2 dari 3anuan m#t#ri6 ! trem#r&

riiditas& bra"inesia, dari 5 anuan m#t#ri6 !

rem#r& riiditas& bra"ibesia&+#stura' instabi'itas,

7 2 dari 3 tanda 6ardina' anuanm#t#ri" ! trem#r saat istira%at atauanuan re)e"s +#stura'& riiditas&bradi"inesia (an ber'ansun 1 ta%unatau 'ebi%,

7 Res+#ns tera+i 'e8#d#+a (an diberi"ansam+ai +erbai"an sedan minima' 1,000

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PENATALAKSANAAN

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FAR:AKOLOIK 

DA1er$i! 

L7d#+a

D#+a7de6arb#*('asein%ibit#r 6arbid#+a

• Sinemet• .en;era;ide• :ad#+ar

:AO dan <O:Tin%ibit#r

D#+amin a#nis

Er#t!•.r#m#6ri+tine•<aber#'ine•Lisuride•Per#'ide

N#n7er#t!•Prami+e*#'e•Ra+inir#'e• Ta'i+e*#'e

A'ti!%i'er$i!    •  T%ri%e*(+%enid(' artane• .en;tr#+in 6#nentin

G%uta&at a'ta$'is

• Amantadine• :emantadine• Rema6emide

Pe%i'du'$ 'eur'

• Neur#t%r#+i6 a6t#r• Anti7e*#t#*in• Anti #"sidan• .i#enereti6 su++'ement•

Immun#su+ressant

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a,Anti"#'ineri" 1

.eruna untu" menenda'i"an e4a'a dari +en(a"it +ar"ins#n,

/ntu" mena'us"an +erera"an,

b,<arbid#+a9'e8#d#+a

Le8#d#+a meru+a"an +en#batan utama untu" +en(a"it +ar"ins#n,Le8#d#+a menurani trem#r& "e"a"uan #t#t dan mem+erbai"i

era"an,

Di da'am #ta" 'e8#d#+a diruba% men4adi d#+amine, L7d#+a a"andiuba% men4adi d#+amine +ada neur#n d#+amineri" #'e% L7

ar#mati" asam amin# de"arb#"si'ase d#+a de"arb#"si'ase,

<arbid#+a dan bensera;ide ada'a% d#+a de"arb#"si'ase in%ibit#r&

membantu men6ea% metab#'isme L7D#+a sebe'um men6a+aineur#n d#+amineri", 3

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Ee" sam+in 'e8#d#+a !

1Neusea& munta%& distress abd#mina'

2Hi+#tensi +#stura'

3Sese"a'i a"an dida+at"an aritmia 4antun&5Dis"inesia,era"an m#t#ri" tida" ter"#ntr#' +ada an#ta

era" mau+un tubu%,

=Abn#rma'itas 'ab#rat#rium, ranu'#sit#+enia&unsi %ati abn#rma' dan ureum dara% (anmenin"at meru+a"an "#m+'i"asi (an 4aranter4adi +ada tera+i 'e8#d#+a,

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Masa

Pe'$)ata'

Dsis Fre!ue'si Pe&)eria'

Mi'$$u !e 2 12= m 2*se%ari

Mi'$$u !e 3 12= m 5*se%ari

Mi'$$u !e 4 2=0m 5*se%ari

Mi'$$u !e 5 =00m 3* se%ari

Mi'$$u !e 6 =00m 5* se%ari

Mi'$$u !e 7 =00m =* se%ari

Mi'$$u !e 8 1 r 3* se%ari

Mi'$$u !e 9 1 r 3* se%ari > =00 m di ma'am %ari

 Tabe', Ped#man D#sis Le8#d#+a /ntu" Pasien Ra$at ?a'an 5

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6,<O:T in%ibit#rs

Enta6a+#ne <#mtan& T#'6a+#ne Tasmar, /ntu" men#ntr#')u"tuasi m#t#r +ada +asien (an menuna"an #bat 'e8#d#+a,

d,A#nis d#+amin

Obat ini be"er4a denan meransan rese+t#r d#+amin& a"anteta+i #bat ini 4ua men(ebab"an +enurunan rese+t#r d#+aminse6ara +r#resi (an se'an4utn(a a"an menimbu'"an

+enin"atan e4a'a Par"ins#n, 5

Obat ini da+at beruna untu" men#bati +asien (an +erna%mena'ami seranan (an ber)u"tuasi dan dis"inesia sebaaia"ibat dari 'e8#d#+a d#sis tini, A+#m#r-n da+at diin4e"si"ansub"utan, D#sis renda% (an diberi"an setia+ %ari da+atmenurani )u"tuasi e4a'a m#t#ri", 3

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e,:AO7. in%ibit#rs

Se'ei'ine E'de+r('& Rasaa'ine A;i'e6t,

In%ibit#r :AO didua beruna +ada +en(a"itPar"ins#n "arena neu#transmisi d#+amineda+at ditin"at"an denan men6ea%+erusa"ann(a,

,Amantadine S(mmetre'

.eruna untu" +era$atan a"inesia&

d(s"inesia& "e"a"uan& emetaran

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Fen#mena On-Of 

Saat on , +enderita da+at berera" denan muda%& terda+at+erbai"an +ada e4a'a trem#r dan "e"a"uann(a,

Saat of , +enderita sanat su'it berera"& trem#r dan"e"a"uan tubu% menin"at,

Wearing of ada'a% Peri#de of (an mun6u' se4a" a$a'+emberian 'e8#d#+a dan ta" da+at diatasi denanmenin"at"an d#sis. Pema"ai 'ama 'e8#d#+a da+atmenimbu'"an e4a'a dis"inesia,

Wearing of dan dis"inesia  "adan7"adan tida" da+at

di"#ntr#' denan tera+i medi"ament#sa dan +er'u+embeda%an,

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NON7FAR:AKOLOIK 

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 TERAPI REHA.ILITASI

Lati%an (an di+er'u"an me'i+uti 'ati%anfsioterapi, okupasi, psikoterapi 

Lati%an -si#tera+i me'i+uti !

Lati%an e'an ba%u denan t#n"at

Lati%an e"stensi trun"us

Lati%an Fren"'e @ ber4a'an denan mena+a""an

"a"i +ada tanda7tanda di 'antaiLati%an is#metri6 untu" #t#t "uadrise+ em#risdan #t#t e"stens#r +anu' aar memuda%"annai" tana dan ban"it dari "ursi

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 TERAPI REHA.ILITASI

Lati%an #"u+asi (an memer'u"an+en"a4ian a"ti8itas "e%idu+an se%ari7%ari&'in"unan tem+at tina' dan +e"er4aan

Psi"#tera+i untu" men"a4i unsi "#niti&"e+ribadian& status menta' +asien dan"e'uara

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PENAKIT PARKINSON

NON7FAR:AKOLOIS FAR:AKOLOIS

Neur#+r#te"si

Disabi'itas unsi

 A  TIDAK 

L7d#+a 7 DDI

Hi'ann(a ee"ti-tas

><O:TI > A#nis DA

D#sis L7d#+aB > a#nis

DA

> <O:TI

D#sis L7d#+a B

L7d#+a>DDI><O:TI

Hi'ann(a ee"ti-tas

D#sis L7d#+a B > a#nis DA

A#nis DA

A#nis DA diuba%

L7d#+a>DDI

> <O:TI

D#sis L7d#+a B

Hi'ann(a ee"ti-tas

L7d#+a 7 DDI

D#sis L7d#+a B

K#ndisi memburu" +r#resi 

OPERASI

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 TERI:A KASIHC,