POLE HOSPITALIER BIOLOGIE - medecine.univ-amu.fr · INTITULÉ : Service de Biochimie Hôpital de la Conception, ... the intestinal microbiome and metabolism in mice. Microb Pathogenesis

Pôle hospitalier. Biologie 1/28

POLE HOSPITALIER BIOLOGIE

CHEF DE PÔLE : Professeur Bruno Lacarelle ADRESSE : Hôpital de la Timone – Service de Pharmacocinétique et Toxicologie

264 Rue Saint Pierre - 13385 Marseille Cedex 5 TELEPHONE : 04.91.38.75.65 COURRIEL : [email protected] ECOLE DOCTORALE : Sciences de la Vie et de la Santé RATTACHEMENTS : AP-HM DISCIPLINES D’APPARTENANCE : Biochimie et Biologie Moléculaire, Hématologie, Immunologie, Génétique, Biologie Cellulaire, Pharmacologie, Toxicologie, Oncologie SPECIALITÉS : Biochimie et Biologie Moléculaire, Hématologie, Immunologie, Génétique, Biologie Cellulaire, Pharmacologie, Toxicologie, Oncologie

EFFECTIFS Enseignants-Chercheurs (PU-PH, MCU-PH, CCA, AHU) : 32,54 ETP Personnel Hospitalier (PH, Attaché) : 47,91 ETP (PC, Ass Spé. & Divers) : 4,9 ETP Personnel Technique (Encadrement) : 13,70 ETP (Techniciens de Laboratoire) : 254,20 ETP (Ingénieurs) : 27,70 ETP (Aide de Laboratoire – AEQ & Divers) : 37,80 ETP Personnel Administratif : 45,30 ETP Internes : 51,00 ETP Etudiants : 75,00 ETP

PERSONNELS RATTACHÉS A UNE EQUIPE DE RECHERCHE INSERM UMR_S910 Nicolas Lévy (PU-PH) Catherine Badens (PU-PH) Christophe Beroud (PU-PH) Pierre Cau (PU-PH) Nicole Philip (PU-PH) Martin Krahn (MCU-PH) Karine Nguyen (MCU-PH) Patrice Roll (MCU-PH) Andrée Robaglia-Schlupp (MCU-PH) Rafaelle Bernard (PH) Nathalie Bonello-Palot (PH) Annachiara De Sandre-Giovanolli (PH) Sabine Sigaudy (PH) Elise Kaspi (AHU) Nathalie Banzet (Ingénieur AP-HM)

Mise à jour du 11 mars 2014


UMR NORT inserm 1062, inra 1260 Marie-Christine Alessi (PU-PH) Laurence Camoin-Jau (PU-PH) Pierre-Emmanuel Morange (PU-PH) Henri Portugal (PU-PH) Marie-Françoise Aillaud (MCU-PH) Véronique Baccini (MCU-PH) Alain Margotat (MCU-PH) Corinne Frère (MCU-PH) Richard Planells (MCU-PH) Alain Nicolay (MCU-PH) C Grosdidier (AHU) William Cohen (AHU) UMR 7289 CNRS Joëlle Micaleff (MCU-PH) UMR 7286 Alain Enjalbert (PU-PH) Anne Barlier (PU-PH) Jean-Louis Berge Lefranc (MCU-PH) A Saveanu UMR 7286 Amapola Autillo-Touati (PU-PH) EA3279 Nicolas Simon (PU-PH) INSERM U911 (CRO2) Bruno Lacarelle (PU-PH) L’Houcine Ouafik (PU-PH) Caroline Solas (MCU-PH) Suzanne Monjanel (MCU-Attaché) Joseph Ciccolini (MCU-Attaché) INSERM 1072 Jean Gabert (PU-PH) Annie Lévy-Mozziconacci (MCU-PH) Christine Formisano ingénieur d’étude UMR INSERM 1067/CNRS 7333 Pierre Bongrand (PU-PH) Joana Vitte (MCU-PH) Philippe Robert Unité INSERM 911 Gilbert Pommier (MCU-PH)



UMR CNRS 7259 Sophie Desplat-Jego (MCU-PH) UMR CNRS 7259 José Boucraut (MCU-PH) Centre d’Immunologie de Marseille Luminy Eric Vivier (PU-PH) Frédéric Vély (MCU-PH) Unité INSERM 1076 Nathalie Bardin (MCU-PH) Unité INSERM 1095 Julien Textoris (MCU-PH) URMIT, Unité Mixte de Recherche 6236 Christophe BUFFAT (MCU-PH) UMR 1076 Françoise Dignat-George (PU-PH) Florence Sabatier (PU-PH) Romaric Lacroix (MCU-PH) Pascale Paul UMR MD2 Régis Guieu (PU-PH) Marguerite Gastaldi (MCU-PH) Pierre-Jean Lejeune (MCU-PH) Julien Fromonot (AHU)

SERVICES HOSPITALIERS

INTITULÉ : Département de Génétique Médicale, Hôpital de la Timone RESPONSABLE : Pr Nicolas Levy DISCIPLINE : Génétique INTITULÉ : Service de Biologie Cellulaire, Hôpital de la Timone RESPONSABLE : Dr Patrice Roll DISCIPLINE : Biologie Cellulaire INTITULÉ : Service d’Hématologie Hôpital Nord et Hôpital de la Timone RESPONSABLE : Professeur Pierre-Emmanuel Morange DISCIPLINE : Hématologie INTITULÉ : Service de Pharmacologie Clinique, Hôpital de la Timone RESPONSABLE : Pr Nicolas Simon DISCIPLINE : Pharmacologie



INTITULÉ : Service de Pharmacocinétique et Toxicologie, Hôpital de la Timone RESPONSABLE : Pr B Lacarelle DISCIPLINE : Pharmacocinétique Toxicologie INTITULÉ : Service de Biochimie Hôpital de la Conception, Biochimie Endocrinienne Hôpital de la Timone, Biochimie et Hématologie Hôpitaux Sud RESPONSABLE : Pr. Henri Portugal DISCIPLINE : Biochimie et Hématologie INTITULÉ : Service de Biologie Moléculaire, Hôpital de la Conception RESPONSABLE : Pr Alain Enjalbert DISCIPLINE : Biologie Moléculaire INTITULÉ : Service de Biochimie et Biologie Moléculaire, Hôpital NORD RESPONSABLE : Pr Jean Gabert DISCIPLINE : Biochimie et Biologie Moléculaire INTITULÉ : Service d’Immunologie, Hôpital de la Conception RESPONSABLE : Pr Pierre Bongrand DISCIPLINE : Immunologie INTITULÉ : Service d’Hématologie et de Biologie Vasculaire, Hôpital de la Conception RESPONSABLE : Pr Françoise Dignat-George DISCIPLINE : Hématologie, Immunologie, Biologie Vasculaire INTITULÉ : Laboratoire de Biochimie, Hôpital de la Timone RESPONSABLE : Pr Régis Guieu DISCIPLINE : Biochimie INTITULÉ : Service de Transfert d’Oncologie Biologique, Hôpital Nord (Faculté de Médecine) RESPONSABLE : Pr L’Houcine Ouafik DISCIPLINE : Biochimie et Biologie Moléculaire – Oncologie Biologique

PUBLICATIONS ANNÉE 2012

Abravanel F, Raymond S, Pambrun E, Winnock M, Bonnard P, Sogni P, Trimoulet

P, Dabis F, Salmon-Ceron D, Izopet J; ANRS CO13 HEPAVIH Study Group. HIV-1 tropism and liver fibrosis in HIV-HCV co-infected patients. PLoS One. 2012;7(11):e50289. doi: 10.1371/journal.pone.0050289. Epub 2012 Nov 30.

Ait-Belkacem R, Calligaris D, Sellami L, Villard C, Granjeaud S, Schembri T, Berenguer C, Ouafik L, Figarella-Branger D, Chinot O, Lafitte D. Tubulin isoforms identified in the brain by MALDI in-source decay. J Proteomics. 2012;79C:172-179. PMID: 23279932.

Alvarez-Breckenridge CA, Yu J, Price R, Wojton J, Pradarelli J, Mao H, Wei M, Wang Y, He S, Hardcastle J, Fernandez SA, Kaur B, Lawler SE, Vivier E, Mandelboim O, Moretta A, Caligiuri MA, Chiocca EA. NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors.Nat Med. 2012 Dec;18(12):1827-34. doi: 10.1038/nm.3013. Epub 2012 Nov 25.

Angelakis E, Bastelica D, Ben Amara A, El Filali A, Dutour A, Mege JL, Alessi MC, Raoult D. An evaluation of the effects of Lactobacillus ingluviei on body weight, the intestinal microbiome and metabolism in mice. Microb Pathogenesis. 2012;52:61-8



Antony-Debré I, Bluteau D, Itzykson R, Baccini V, Renneville A, Boehlen F, Morabito M, Droin N, Deswarte C, Chang Y, Leverger G, Solary E, Vainchenker W, Favier R, Raslova H. MYH10 protein expression in platelets as a biomarker of RUNX1 and FLI1 alterations. Blood. 2012 120:2719-22

Attarian S, Salort-Campana E, Nguyen K, Behin A, Andoni Urtizberea J. Recommendations for the management of facioscapulohumeral muscular dystrophy in 2011. Rev Neurol (Paris). 2012 Dec;168(12):910-8.

Aye M, Di Giorgio C, Berque-Bestel I, Aime A, Pichon BP, Jammes Y, Barthélémy P, De Méo M.Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots.Mutat Res. 2012 Nov 10.

Bahi-Buisson N, Villeneuve N, Caietta E, Jacquette A, Maurey H, Matthijs G, Van Esch H, Delahaye A, Moncla A, Milh M, Zufferey F, Diebold B, Bienvenu T. Recurrent mutations in the CDKL5 gene: genotype-phenotype relationships. Am J Med Genet A. 2012 Jul;158A(7):1612-9.

Balducci E, Cointe S, Lacroix R , Sabatier F et Dignat-George F. Microparticules circulantes, acteurs et marqueurs emergents en pathologie humaine. Revue Francophone des Laboratoires 2012. 433; 29-38.

Baranek T, Manh TP, Alexandre Y, Maqbool MA, Cabeza JZ, Tomasello E, Crozat K, Bessou G, Zucchini N, Robbins SH, Vivier E, Kalinke U, Ferrier P, Dalod M. Differential responses of immune cells to type I interferon contribute to host resistance to viral infection. Cell Host Microbe. 2012 Oct 18;12(4):571-84. doi: 10.1016/j.chom.2012.09.002

Barbaux S,Gascoin-Lachambre G,Buffat C,Monnier P,Mondon F,Tonanny MB,Pinard A,Auer J,Bessières B,Barlier A,Jacques S,Simeoni U,Dandolo L,Letourneur F,Jammes H,Vaiman D A genome-wide approach reveals novel imprinted genes expressed in the human placenta. Epigenetics 7 1079-90 2012

Bartoli M, Nègre P, Wein N, Bourgeois P, Pécheux C, Lévy N, Krahn M.Validation of comparative genomic hybridization arrays for the detection ofgenomic rearrangements of the calpain-3 and dysferlin genes. Clin Genet. 2012 Jan;81(1):99-101.

Bartoli MA, Kober F, Cozzone P, Thompson RW, Alessi MC, Bernard M. In vivo assessment of murine elastase-induced abdominal aortic aneurysm with high resolution magnetic resonance imaging. Eur J Vasc Endovasc Surg. 2012;44:475-81

Bataille S, Kaplanski G, Boucraut J, Halfon P, Camus C, Daniel L, Burtey S, Berland Y, Dussol B. Membranoproliferative glomerulonephritis and mixed cryoglobulinemia after hepatitis C virus infection secondary to glomerular NS3 viral antigen deposits.Am J Nephrol. 2012;35(2):134-40. doi: 10.1159/000335375. Epub 2012 Jan 13

Beaufils N, Ben Lassoued A, Essaydi A, Dales JP, Formisano-Tréziny C, Bonnet N, Grob JJ, Gabert J. Analysis of T-cell receptor-γ gene rearrangements using heteroduplex analysis by high-resolution microcapillary electrophoresis.Leuk Res. 2012 Sep;36(9):1119-23.

Benay S, Fanciullino R, Mercier C, Iliadis A, Ciccolini J, Lacarelle B. 100% human monoclonal antibodies in oncology: hype or breakthrough? Curr Top Med Chem. 2012;12(15):1643-8.

Bennani B, Bennis S, Nejjari C, Ouafik L, Melhouf MA, El Rhazi K, Znati K, Chaara H, Bouchikhi C, Amarti Riffi A. Correlates of HPV: a cross-sectional study in women with normal cytology in north-central Morocco. J Infect Dev Ctries. 2012;6:543-50. PMID: 22842940.



Bennis Y, Pellegrini L, Guillet B, Velly L, Bruder N, Pisano P. Cell Therapy For Stroke: From Myth To Reality. Rev Neurol (Paris). 2012 Dec 13

Bennis Y, Sarlon-Bartoli G, Guillet B, Hubert L, Pellegrini L, Velly L, Blot-Chabaud M, Dignat-Georges F, Sabatier F, Pisano P. Priming of late endothelial progenitor cells with erythropoietin before transplantation requires the CD131 receptor subunit and enhances their angiogenic potential. J Thromb Haemost. 2012 Sep;10(9):1914-28.

Besançon A., C. Schmitt, M. Glaizal, L. Tichadou, K. Klouche, M. Hayek-Lanthois, L. de Haro. Survenue d’une atteinte cardiaque sévère au cours du syndrome proximien : deux observations originales. Ann Fr Anesth Réanim 2012, 31 : 466 – 8.

Bine S, Haziot A, Malikova I, Pelletier J, Charron D, Boucraut J, Mooney N, Gelin C. Alteration of CD1 expression in multiple sclerosis. Clin Exp Immunol. 2012 Jul;169(1):10-6. doi: 10.1111/j.1365-2249.2012.04586.x

Bitounis D, Fanciullino R, Iliadis A, Ciccolini J. Optimizing Druggability through Liposomal Formulations: New Approaches to an Old Concept. ISRN Pharm. 2012;2012:738432. doi: 10.5402/2012/738432. Epub 2012 Feb 9.

Blandin G, Beroud C, Labelle V, Nguyen K, Wein N, Hamroun D, Williams B,Monnier N, Rufibach LE, Urtizberea JA, Cau P, Bartoli M, Lévy N, Krahn M.UMD-DYSF, a novel locus specific database for the compilation and interactiveanalysis of mutations in the dysferlin gene. Hum Mutat. 2012 Mar;33(3):E2317-31.

Bluteau D, Glembotsky AC, Raimbault A, Balayn N, Gilles L, Rameau P, Nurden P, Alessi MC, Debili N, Vainchenker W, Heller PG, Favier R, Raslova H. Dysmegakaryopoiesis of FPD/AML is linked to myosin II deregulated expression. Blood. 2012;120:2708-18

Boczek C, Frauger E, Micallef J, Allaria-Lapierre V, Reggio P, Sciortino V. National and Regional Market Penetration Rates of Generic's High Dosage Buprenorphine: Its Evolution from 2006 to 2008, Using Reimbursed Drug Database Therapie 2012 Mar-Apr;67(2):129-36.

Boels D., L. de Haro, P. Harry. La banque des sérums antivenimeux (BSA). Infotox, Bulletin d’information de la Société de Toxicologie Clinique 2012, 38 :1 – 3.

Bonello L, Berbis J, Laine M, Armero S, Bessereau J, Jacquin L, Bonello C, Camillieri E, Barragan P, Dignat-George F, Paganelli F, Camoin-Jau L. Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction.Thromb Haemost. 2012 Jul;108(1):101-6.

Bonello L, Berbis J, Laine M, Armero S, Bessereau J, Jacquin L, Bonello C, Camillieri E, Barragan P, Dignat-George F, Paganelli F, Camoin-Jau L. Biological efficacy of a 600 mg loading dose of clopidogrel in ST-elevation myocardial infarction. Thromb Haemost. 2012;108:101-6

Bonello L, Camoin-Jau L, Mancini J, Bessereau J, Grosdidier C, Alessi MC, Ostorero M, Dignat-George F, Paganelli F. Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade. Thromb Res. 2012 Jul;130(1):70-4.

Bonello L, Camoin-Jau L, Mancini J, Bessereau J, Grosdidier C, Alessi MC, Ostorero M, Dignat-George F, Paganelli F. Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade. Thromb Res. 2012;130:70-4



Bonello L, Harhouri K, Baumstarck K, Arnaud L, Lesavre N, Piot C, Paganelli F, Dignat-George F, Sabatier F. Mobilization of CD34(+) KDR(+) endothelial progenitor cells predicts target lesion revascularization. J Thromb Haemost. 2012 Sep;10(9):1906-1913.

Bonello L, Mancini J, Pansieri M, Maillard L, Rossi P, Collet F, Jouve B, Wittenberg O, Laine M, Michelet P, Bessereau J, Lemesle G, Dignat-George F, Paganelli F, Camoin-Jau L. Relationship between post-treatment platelet reactivity and ischemic and bleeding events at one year follow-up in patients receiving prasugrel. J Thromb Haemost. 2012; 10:1999-2005

Bonello L, Mancini J, Pansieri M, Maillard L, Rossi P, Collet F, Jouve B, Wittenberg O, Laine M, Michelet P, Bessereau J, Lemesle G, Dignat-George F, Paganelli F, Camoin-Jau L. Relationship between post-treatment platelet reactivity and ischemic and bleeding events at 1-year follow-up in patients receiving prasugrel. J Thromb Haemost. 2012 Oct;10(10):1999-2005.

Bourcier V, Winnock M, Ait Ahmed M, Sogni P, Pambrun E, Poizot-Martin I, Chaffaut C, Chevret S, Trinchet JC, Salmon D; ANRS CO13 Hepavih study group; ANRS CO12 Cirvir study group. Primary liver cancer is more aggressive in HIV-HCV coinfection than in HCV infection. A prospective study (ANRS CO13 Hepavih and CO12 Cirvir). Clin Res Hepatol Gastroenterol. 2012 Jun;36(3):214-21

Boussuges A, Gavarry O.Exercise on land or in water?Int J Gen Med. 2012;5:313-4; discussion 315-6

Brignole M, Menozzi C, Moya A, Andresen D, Blanc JJ, Krahn AD, Wieling W, Beiras X, Deharo JC, Russo V, Tomaino M, Sutton R; International Study on Syncope of Uncertain Etiology 3 (ISSUE-3) Investigators.Pacemaker therapy in patients with neurally mediated syncope and documented asystole:Third International Study on Syncope of Uncertain Etiology (ISSUE-3): a randomized trial.Circulation. 2012 May 29;125(21):2566-71.

Bronnert M, Mancini J, Birnbaum J, Agabriel C, Liabeuf V, Porri F, Cleach I, Fabre A, Deneux I, Grandné V, Grob JJ, Berbis P, Charpin D, Bongrand P, Vitte J. Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy.Clin Exp Allergy. 2012 Sep;42(9):1406-15).

Bun SS, Kober F, Jacquier A, Espinosa L, Kalifa J, Bonzi MF, Kopp F, Lalevee N, Zaffran S, Deharo JC, Cozzone PJ, Bernard M.Value of in vivo T2 measurement for myocardial fibrosis assessment in diabetic mice at 11.75 T.Invest Radiol. 2012 May;47(5):319-23.

Bun SS, Latcu DG, Prévôt S, Bastard E, Franceschi F, Ricard P, Saoudi N, Deharo JC. Characteristics of recurrent clockwise atrial flutter after previous radiofrequency catheter ablation for counterclockwise isthmus-dependent atrial flutter.Europace. 2012 Sep;14(9):1340-3.

Bun SS, Maury P, Giustetto C, Deharo JC.Electrical storm in short-QT syndrome successfully treated with Isoproterenol.J Cardiovasc Electrophysiol. 2012 Sep;23(9):1028-30.

By Y, Jacquin L, Franceschi F, Durand-Gorde JM, Condo J, Michelet P, Guieu R, Ruf J.Fall in oxygen tension of culture medium stimulates the adenosinergic signalling of a human T cell line. Purinergic Signal. 2012 Dec;8(4):661-7.

Caillol G, Vacher H, Musarella M, Bellouze S, Dargent B, Autillo-Touati A.Motor endplate disease affects neuromuscular junction maturation.Eur J Neurosci. 2012 Aug;36(4):2400-8. doi: 10.1111/j.1460-9568.2012.08164.x. Epub 2012 May 30.



Cardiogenic consortium: Morange PE, Koenig W, Soranzo N, van der Harst P, Liu Y, O'Donnell CJ, Hamsten A. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood. 2012;120:4873-81

Castinetti F,Reynaud R,Saveanu A,Barlier A,Brue T Genetic causes of combined pituitary Hormone deficiencies in humans. Ann Endocrinol (Paris) 73 53-5 2012

Cautela J, Alessandrini S, Cammilleri S, Giorgi R, Richet H, Casalta JP, Habib G, Raoult D, Mundler O, Deharo JC.Diagnostic yield of FDG positron-emission tomography/computed tomography in patients with CEID infection: a pilot study.Europace. 2012 Nov 12.

Chefrour M, Milano G, Formento P, Giacometti S, Denden A, Renée N, Iliadis A, Fischel JL, Ciccolini J. Positive interaction between lapatinib and capecitabine in human breast cancer models: study of molecular determinants. Fundam Clin Pharmacol. 2012 Aug;26(4):530-7.

Chenaitia H, Fournier M, Brun JP, Michelet P, Auffray JP.Association of mechanical chest compression and prehospital thrombolysis.Am J Emerg Med. 2012 Jul;30(6):1015

Chiche L, Forel JM, Thomas G, Farnarier C, Cognet C, Guervilly C, Zandotti C, Vély F, Roch A, Vivier E, Papazian L. Interferon-γ production by natural killer cells and cytomegalovirus in critically ill patients.Crit Care Med. 2012 Dec;40(12):3162-9. doi: 10.1097/CCM.0b013e318260c90e.

Chiche L, Jourde N, Thomas G, Bardin N, Bornet C, Darque A, Mancini J. New treatment options for lupus - a focus on belimumab.Ther Clin Risk Manag. 2012;8:33-43. doi: 10.2147/TCRM.S19819. Epub 2012 Jan 26

Chiche L, Jourde N, Ulmann C, Mancini J, Darque A, Bardin N, Dicostanzo MP, Thomas G, Harlé JR, Vienne J, Loukos H, Bornet C. Seasonal variations of systemic lupus erythematosus flares in southern France.Eur J Intern Med. 2012 Apr;23(3):250-4. doi: 10.1016/j.ejim.2011.12.006. Epub 2012 Jan 9.

Chiossone L, Audonnet S, Chetaille B, Chasson L, Farnarier C, Berda-Haddad Y, Jordan S, Koszinowski UH, Dalod M, Mazodier K, Novick D, Dinarello CA, Vivier E, Kaplanski G. Protection from inflammatory organ damage in a murine model of hemophagocytic lymphohistiocytosis using treatment with IL-18 binding protein.Front Immunol. 2012;3:239. doi: 10.3389/fimmu.2012.00239. Epub 2012 Aug 8.

Ciccolini J, Evrard A, Lacarelle B. A CDD polymorphism as predictor of capecitabine-induced hand-foot syndrome--letter. Clin Cancer Res. 2012 Jan 1;18(1):317. doi: 10.1158/1078-0432.CCR-11-1360. No abstract available.

Ciccolini J, Evrard A, M'Batchi L, Pourroy B, Mercier C, Iliadis A, Lacarelle B, Verschuur A, Ouafik L, André N. CDA deficiency as a possible culprit for life-threatening toxicities after cytarabine plus 6-mercaptopurine therapy: pharmacogenetic investigations. Pharmacogenomics. 2012 Mar;13(4):393-7. doi: 10.2217/pgs.11.175.

Ciccolini J, Evrard A, M'Batchi L, Pourroy B, Mercier C, Iliadis A, Lacarelle B, Verschuur A, Ouafik L, André N. CDA deficiency as a possible culprit for life-threatening toxicities after cytarabine plus 6-mercaptopurine therapy:pharmacogenetic investigations. Pharmacogenomics. 2012;13:393-7. PMID: 22379997.

Ciccolini J. Editorial: targeted therapy, targeted dosing and targeted delivery in oncology: where do we stand? Curr Top Med Chem. 2012;12(15):1638. No abstract available.



Cohen W, Castelli C, Alessi MC, Aillaud MF, Bouvet S, Saut N, Brunet D, Barthet MC, Tregouet DA, Lavigne G, Morange PE. ABO blood group and von willebrand factor levels partially explained the incomplete penetrance of congenital thrombophilia. Arterioscl Thromb Vasc Biol. 2012;32:2021-8

Contargyris C, Nee L, Saby C, Kerbaul F, Peytel E.[Phaeochromocytoma revealed by a cardiogenic shock treated by extracorporeal life support].Ann Fr Anesth Reanim. 2012 Dec;31(12):965-8.

Corbani S, Chouery E, Fayyad J, Fawaz A, El Tourjuman O, Badens C, Lacoste C, Delague V, Megarbane A. Molecular screening of MECP2 gene in a cohort of Lebanese patients suspected with Rett syndrome: report on a mild case with a novel indel mutation. J Intellect Disabil Res. 2012 Apr;56(4):415-20.

Costello RT, Knoblauch B, Sanchez C, Mercier D, Le Treut T, Sébahoun G. Expression of natural killer cell activating receptors in patients with chronic lymphocytic leukaemia. Immunology. 2012 ;135:151-7

Courcet JB, Faivre L, Malzac P, Masurel-Paulet A, Lopez E, Callier P, Lambert L, Lemesle M, Thevenon J, Gigot N, Duplomb L, Ragon C, Marle N, Mosca-Boidron AL, Huet F, Philippe C, Moncla A, Thauvin-Robinet C. The DYRK1A gene is a cause of syndromic intellectual disability with severe microcephaly and epilepsy.J Med Genet. 2012 Dec;49(12):731-6.

Couture C,Saveanu A,Barlier A,Carel JC,Fassnacht M,Flück CE,Houang M,Maes M,Phan-Hug F,Enjalbert A,Drouin J,Brue T,Vallette S Phenotypic homogeneity and genotypic variability in a large series of congenital isolated ACTH-deficiency patients with TPIT gene mutations. J Clin Endocrinol Metab 97 E486-95 2012

Cristofaro B, Shi Y, Faria M, Suchting S, Leroyer AS, Trindade A, Duarte A, Zovein AC, Iruela-

Crocchiolo R, Ciccolini J, El-Cheikh J, Fürst S, Castagna L, Granata A, Oudin C, Harbi S, Devillier R, Legall S, Ternant D, Paintaud G, Lacarelle B, Blaise D. Successful treatment of post-transplant Epstein-Barr virus-related meningoencephalitis by intravenous rituximab monotherapy. Leuk Lymphoma. 2012 Oct;53(10):2063-5. doi: 10.3109/10428194.2012.670232. Epub 2012 Apr 19.

Cuisset T, Gaborit B, Dubois N, Quilici J, Loosveld M, Beguin S, Loundou AD, Moro PJ, Morange PE, Alessi MC, Dutour A, Bonnet JL. Platelet reactivity in diabetic patients undergoing coronary stenting for acute 2 coronary syndrome treated with clopidogrel loading dose followed by prasugrel maintenance therapy. Int J Cardiol. 2012 (in press)

Cuisset T, Loosveld M, Quilici J, Gaborit B, Grosdidier C, Fourcade L, Gil JM, Moro PJ, Morange PE, Bonnet JL, Alessi MC. CYP2C19 *2 and *17 alleles have a significant Impact on Platelet Response and Bleeding Risk in patients treated with Prasugrel after Acute Coronary Syndrome. J Am Coll Cardiol. 2012;5:1280-7

Cuisset T, Morange PE, Alessi MC. Recent advances in the pharmacogenetics of clopidogrel. Hum Genet. 2012;131:653-64

Cuisset T, Quilici J, Loosveld M, Gaborit B, Grosdidier C, Fourcade L, Gil JM, Moro PJ, Morange PE, Bonnet JL, MC Alessi. Comparison between initial and chronic response to clopidogrel therapy after coronary stenting for acute coronary syndrome and influence on clinical outcomes. Am Heart J. 2012;164:327-33

Cuny T,Mohamed A,Graillon T,Roche C,Defilles C,Germanetti AL,Couderc B,Figarella-Branger D,Enjalbert A,Barlier A,Saveanu A Somatostatin receptor sst2 gene transfer in human prolactinomas in vitro: impact on sensitivity to dopamine, somatostatin and dopastatin, in the control of prolactin secretion. Mol Cell Endocrinol 355106-13 2012



Dahan L, Ciccolini J, Evrard A, Mbatchi L, Tibbitts J, Ries P, Norguet E, Mercier C, Iliadis A, Ouafik L, Lacarelle B, Seitz JF. Sudden death related to toxicity in a patient on capecitabine and irinotecan plus bevacizumab intake: pharmacogenetic implications. J Clin Oncol. 2012; 30:e41-4. PMID: 22184401

Darbousset R, Thomas G, Mezouar S, Mackman N, Renné T., Dignat- George F, Dubois C., Panicot-Dubois L. Neutrophils initiate coagulation on injured vessel wall. Int Journal laboratory hematology 2012 34 supplement 1

Darbousset R, Thomas GM, Mezouar S, Frère C, Bonier R, Mackman N, Renné T, Dignat-George F, Dubois C, Panicot-Dubois L. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood. 2012 ;120:2133-43

Darbousset R, Thomas GM, Mezouar S, Frère C, Bonier R, Mackman N, Renné T, Dignat-George F, Dubois C, Panicot-Dubois L. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood. 2012;120:2133-43.

Darbousset R, Thomas GM, Mezouar S, Frère C, Bonier R, Mackman N, Renné T, Dignat-George F, Dubois C, Panicot-Dubois L; Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood. 2012 Sep 6;120(10):2133-43.

Darouich S, Popovici C, Missirian C, Moncla A. Use of DOP-PCR for amplification and labeling of BAC DNA for FISH. Biotech Histochem. 2012 Feb;87(2):117-21.

Daumas A, Rossi P, Jacquier A, Granel B.Myopericarditis revealing giant cell arteritis in the elderly.J Rheumatol. 2012 Mar;39(3):665-6.

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de Haro L.. Management of snake bites in France. Toxicon 2012, 60(4) : 712 – 8.

de Haro L.. Mise au point sur les intoxications par coquillage et les toxines impliquées. Epitox Bulletin réseau de toxicovigilance et de surveillance des intoxications 2012, 4 :7 – 8.

De Paula AM, Bartoli M, Courrier S, Pouget J, Levy N, Pellissier JF,Figarella-Branger D, Krahn M, Attarian S. Further heterogeneity in myopathy with tubular aggregates? Muscle Nerve. 2012 Dec;46(6):984-5.

Deharo JC, Mechulan A, Giorgi R, Franceschi F, Prevot S, Peyrouse E, Condo J, By Y, Ruf J, Brignole M, Guieu R.Adenosine plasma level and A2A adenosine receptor expression: correlation with laboratory tests in patients with neurally mediated syncope.Heart. 2012 Jun;98(11):855-9. doi: 10.1136/heartjnl-2011-301411.

Deharo JC, Quatre A, Mancini J, Khairy P, Le Dolley Y, Casalta JP, Peyrouse E, Prévôt S, Thuny F, Collart F, Raoult D, Habib G, Franceschi F.Long-term outcomes following infection of cardiac implantable electronic devices: a prospective matched cohort study.Heart. 2012 May;98(9):724-31.

Dennis J, Johnson CY, Adediran AS, de Andrade M, Heit JA, Morange PE, Trégouët DA, Gagnon F. The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies. Blood. 2012;119:2392-400



Descotes F, Jézéquel P, Spyratos F, Campion L, Grenot C, Lerebours F, Campone M, Guérin-Charbonnel C, Lanoë D, Adams M, André J, Carlioz A, Martin PM, Chassevent A, Jourdan ML, Guette C, Zanella-Cleon I, Ricolleau G. Identification of potential prognostic biomarkers for node-negative breast tumours by proteomic analysis: a multicentric 2004 national PHRC study. Int J Oncol. 2012;41:92-104. PMID: 22552268.

Dominguez S, Ghosn J, Cassard B, Melica G, Poizot-Martin I, Solas C, Lascaux AS, Bouvier-Alias M, Katlama C, Lévy Y, Peytavin G. Erythrocyte and plasma ribavirin concentrations in the assessment of early and sustained virological responses to pegylated interferon-alpha 2a and ribavirin in patients coinfected with hepatitis C virus and HIV. J Antimicrob Chemother. 2012 Jun;67(6):1449-52. doi: 10.1093/jac/dks045. Epub 2012 Mar 5.

Dominois-Héraud AM., C. Schmitt, O. de Mattéis, L. Tichadou, L. de Haro. Troubles cardiaques sévères après ingestion d’aconit dans le sud de la France : à propos d’une observation. Ann Fr Anesth Réanim 2012, 31 : 263 – 4.

Doubaj Y, De Sandre-Giovannoli A, Vera EV, Navarro CL, Elalaoui SC, Tajir M,Lévy N, Sefiani A. An inherited LMNA gene mutation in atypical Progeria syndrome.Am J Med Genet A. 2012 Nov;158A(11):2881-7.

Duhoux FP, Ameye G, Montano-Almendras CP, Bahloula K, Mozziconacci MJ, LaibeS, Wlodarska I, Michaux L, Talmant P, Richebourg S, Lippert E, Speleman F, HerensC, Struski S, Raynaud S, Auger N, Nadal N, Rack K, Mugneret F, Tigaud I, LafageM, Taviaux S, Roche-Lestienne C, Latinne D, Libouton JM, Demoulin JB, Poirel HA; Groupe Francophone de Cytogénétique Hématologique (GFCH); Belgian CytogeneticGroup for Haematology and Oncology (BCG-HO). PRDM16 (1p36) translocations define a distinct entity of myeloid malignancies with poor prognosis but may also occur in lymphoid malignancies. Br J Haematol. 2012 Jan;156(1):76-88.

Dupont J, Fromonot J, Franceschi F, Deharo JC, Boucraut J, Quilici J, Bonnet JL, Monserrat C, Guieu R. A case of false positive troponin elevation: role of the biological laboratory.Int J Cardiol. 2013 Jan 20;162(3):e66-7. doi: 10.1016/j.ijcard.2012.06.048. Epub 2012 Jun 28. No abstract available.

Dupouey J, Gerolami R, Solas C, Colson P. Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy. Clin Res Hepatol Gastroenterol. 2012 Apr;36(2):e26-8. doi: 10.1016/j.clinre.2012.01.003. Epub 2012 Feb 18.

Durante L, Zaaraoui W, Rico A, Crespy L, Wybrecht D, Faivre A, Reuter F, Malikova I, Pommier G, Confort-Gouny S, Cozzone PJ, Ranjeva JP, Pelletier J, Boucraut J, Audoin B. Intrathecal synthesis of IgM measured after a first demyelinating event suggestive of multiple sclerosis is associated with subsequent MRI brain lesion accrual.Mult Scler. 2012 May;18(5):587-91. doi: 10.1177/1352458511424589. Epub 2011 Sep 30

Ebbo M, Daniel L, Pavic M, Sève P, Hamidou M, Andres E, Burtey S, Chiche L, Serratrice J, Longy-Boursier M, Ruivard M, Haroche J, Godeau B, Beucher AB, Berthelot JM, Papo T, Pennaforte JL, Benyamine A, Jourde N, Landron C, Roblot P, Moranne O, Silvain C, Granel B, Bernard F, Veit V, Mazodier K, Bernit E, Rousset H, Boucraut J, Boffa JJ, Weiller PJ, Kaplanski G, Aucouturier P, Harlé JR, Schleinitz N.IgG4-related systemic disease: features and treatment response in a French cohort: results of a multicenter registry.Medicine (Baltimore). 2012 Jan;91(1):49-56. doi: 10.1097/MD.0b013e3182433d77.

Ebbo M, Grados A, Bernit E, Vély F, Boucraut J, Harlé JR, Daniel L, Schleinitz N.Pathologies Associated with Serum IgG4 Elevation.Int J Rheumatol. 2012;2012:602809. doi: 10.1155/2012/602809. Epub 2012 Aug 26.



Fabre A, Charroux B, Martinez-Vinson C, Roquelaure B, Odul E, Sayar E, SmithH, Colomb V, Andre N, Hugot JP, Goulet O, Lacoste C, Sarles J, Royet J, Levy N,Badens C. SKIV2L mutations cause syndromic diarrhea, or trichohepatoentericsyndrome. Am J Hum Genet. 2012 Apr 6;90(4):689-92

Faille D, El-Assaad F, Mitchell AJ, Alessi MC, Chimini G, Fusai T, Grau GE, Combes V. Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells. J Cell Mol Med. 2012;16:1731-8

Faure E, Garrouste F, Parat F, Monferran S, Leloup L, Pommier G, Kovacic H, Lehmann M.P2Y2 receptor inhibits EGF-induced MAPK pathway to stabilise keratinocyte hemidesmosomes.J Cell Sci. 2012 Sep 15;125(Pt 18):4264-77. doi: 10.1242/jcs.097600. Epub 2012 Jun 20

Felix MS, Popa N, Djelloul M, Boucraut J, Gauthier P, Bauer S, Matarazzo VA.Alteration of forebrain neurogenesis after cervical spinal cord injury in the adult rat.Front Neurosci. 2012;6:45. doi: 10.3389/fnins.2012.00045. Epub 2012 Apr 9.

Forel JM, Chiche L, Thomas G, Mancini J, Farnarier C, Cognet C, Guervilly C, Daumas A, Vély F, Xéridat F, Vivier E, Papazian L. Phenotype and functions of natural killer cells in critically-ill septic patients.PLoS One. 2012;7(12):e50446. doi: 10.1371/journal.pone.0050446. Epub 2012 Dec 6

Formisano-Tréziny C, de San Feliciano M, Gabert J.Development of plasmid calibrators for absolute quantification of miRNAs by using real-time qPCR.J Mol Diagn. 2012 Jul;14(4):314-21.

Foucher B, Johanet C, Jégo-Desplat S, Sanmarco M, Dubucquoi S, Fily-Nalewajk S, Olsson NO, Lakomy D, Escande A, Chrétien P, Fortenfant F, Chevailler A, André C, Goetz J, Humbel RL, Monier JC, Sibilia J, Taillefer MF, Abreu I, Fabien N.Are immunoglobulin A anti-gliadin antibodies helpful in diagnosing coeliac disease in children younger than 2 years?J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):110-2

Franceschi F, Bonan R, Khairy P, Dubuc M, Thibault B, Macle L, Talajic M, Roy D, Koutbi L, Virmani R, Guerra PG.Histopathological effects and evolution of transvenous β-radiation applications in right and left atria: an animal study.Europace. 2012 May;14(5):745-51

Frauger E, Nordmann S, Orleans V, Pradel V, Pauly V, Thirion X, Micallef J. Which psychoactive prescription drugs are illegally obtained and through which ways of acquisition? About OPPIDUM survey. Fundamental & Clinical Pharmacology 2012 Aug;26(4):549-56

Fujii N, Honda Y, Delliaux S, Tsuji B, Watanabe K, Sugihara A, Kondo N, Nishiyasu T.Effect of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans.Am J Physiol Regul Integr Comp Physiol. 2012 Nov 1;303(9):R975-83.

Gaborit B, Jacquier A, Kober F, Abdesselam I, Cuisset T, Boullu-Ciocca S, Emungania O, Alessi MC, Clément K, Bernard M, Dutour A. Effects of bariatric surgery on cardiac ectopic fat: lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content. J Am Coll Cardiol. 2012 60:1381-9

Gaborit B, Kober F, Jacquier A, Moro PJ, Cuisset T, Boullu S, Dadoun F, Alessi MC, Morange P, Clément K, Bernard M, Dutour A. Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat. Int J Obes. 2012;36:422-30



Gaborit B, Kober F, Jacquier A, Moro PJ, Flavian A, Quilici J, Cuisset T, Simeoni U, Cozzone P, Alessi MC, Clément K, Bernard M, Dutour A. Epicardial fat volume is associated with coronary microvascular response in healthy subjects: a pilot study. Obesity (Silver Spring). 2012;20:1200-5

Gaillard N., J. Couvreur, M. Glaizal, V. Carret, A. Berric, JJ. Raymond, JJ. Arzalier. Intoxication aiguë par la trimébutine. Urgences Pratiques 2012, 112 : 39 – 40.

Gatto F,Barbieri F,Gatti M,Wurth R,Schulz S,Ravetti JL,Zona G,Culler MD,Saveanu A,Giusti M,Minuto F,Hofland LJ,Ferone D,Florio T Balance between somatostatin and D2 receptor expression drives TSH-secreting adenoma response to somatostatin analogues and dopastatins. Clin Endocrinol (Oxf) 76407-14 2012

Gégu C., N. Gagnon, C. Schmitt, L. Tichadou, M. Hayek-Lanthois, L. de Haro. Traitement par doses élevées de baclofène à l’origine d’un surdosage chez un éthylique chronique insuffisant rénal. Thérapie 2012, 67(6) : 529 – 31.

Germain M, Saut N, Oudot-Mellakh T, Letenneur L, Dupuy AM, Bertrand M, Alessi MC, Lambert JC, Zelenika D, Emmerich J, Tiret L, Cambien F, Lathrop M, Amouyel P, Morange PE, Trégouët DA. Caution in interpreting results from imputation analysis when linkage disequilibrium extends over a large distance: a case study on venous thrombosis. PLoS One. 2012;7:e38538

Gimenez E, Chauvet M, Rabin L, Puteaud I, Duley S, Hamaidia S, Bruder J, Rolland-Neyret V, Le Gouill S, Tournilhac O, Voog E, Maisonneuve H, Jacob MC, Leroux D, Béné MC, Formisano-Tréziny C, Gabert J, Gressin R, Callanan MB.Cloned IGH VDJ targets as tools for personalized minimal residual disease monitoring in mature lymphoid malignancies; a feasibility study in mantle cell lymphoma by the Groupe Ouest Est d'Etude des Leucémies et Autres Maladies du Sang.Br J Haematol. 2012 Jul;158(2):186-97.

Gineau L, Cognet C, Kara N, Lach FP, Dunne J, Veturi U, Picard C, Trouillet C, Eidenschenk C, Aoufouchi S, Alcaïs A, Smith O, Geissmann F, Feighery C, Abel L, Smogorzewska A, Stillman B, Vivier E, Casanova JL, Jouanguy E.Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.J Clin Invest. 2012 Mar 1;122(3):821-32. doi: 10.1172/JCI61014. Epub 2012 Feb 22.

Glaizal M., V. Alunni, JJ. Arzalier, G. Page, Y. Gaillard, MD. Piercecchi-Marti, M. Hayek-Lanthois, L. de Haro. Gravité potentielle des intoxications volontaires à la trimébutine. Presse Méd 2012, 41(6) : 662 – 3.

Glaizal M., V. Gazin, I. Aymard, C. Messina-Gourlot, N. Richard, M. Mallaret, P. Saviuc, L. de Haro. Suicidal poisoning with methadone in France: Results of a two year national survey by the Toxicovigilance Network. Clin Toxicol (Phila) 2012, 50(9): 841 – 6.

Goncalves TM, Rizzo JA, Dubus JC, Nicolay A, De Santana DP, De Souza PHN, Figueiroa JN, Andrieu V.In Vitro Performance of Fluticasone/Salmeterol Pressurized Metered Dose Inhaler in Combination with Three Different Valved Holding Chambers.Lat Am J Pharm, 2012, 31(6): 877-882.

Gondouin B, Cerini C, Dou L, Sallée M, Duval-Sabatier A, Pletinck A, Calaf R, Lacroix R, Jourde-Chiche N, Poitevin S, Arnaud L, Vanholder R, Brunet P, Dignat-George F, Burtey S. Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway. Kidney Int (In press)

Granel B, Boufi M, Rossi P, Soussan J, Alimi Y.A voluminous glomus tumor of the leg.QJM. 2012 Aug 26.



Guieu R, Guedj E, Giorgi R, Dousset A, Tuzzolino V, By Y, Leveque JM, Peragut JC, Régis J, Ruf J, Fenouillet E, Roussel P.High cell surface CD26-associated activities and low plasma adenosine concentration in fibromyalgia.Ann Rheum Dis. 2012 Aug;71(8):1427-8.

Gust L,Taieb D,Beliard A,Barlier A,Morange I,de Micco C,Henry JF,Sebag F Preoperative 18F-FDG uptake is strongly correlated with malignancy, Weiss score, and molecular markers of aggressiveness in adrenal cortical tumors.World J Surg 2012 36 1406-10

Hadadeh O, Barruet E, Peiretti F, Verdier M, Bernot D, Hadjal Y, El Yazidi Cl, Nègre D, Iacovino M, Kyba M, Alessi MC, Binétruy B. The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells. PloS One. 2012;7:e49065

Haumonté JB, Camoin-Jau L, Banet J, Mazouni C, Heckenroth H, Dignat-George F, Bretelle F. Factor VIII :C levels in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Int J Gynaecol Obstet. 2012, 116 (3) : 258

Haumonté JB, Camoin-Jau L, Banet J, Mazouni C, Heckenroth H, Dignat-George F, Bretelle F. Factor VIII:C levels in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Int J Gynaecol Obstet. 2012 Mar ;116(3) :258-9

He HT, Bongrand P.Membrane dynamics shape TCR-generated signaling.Front Immunol. 2012;3:90. doi: 10.3389/fimmu.2012.00090. Epub 2012 Apr 26.

Helgadóttir A, Gretarsdottir S, Thorleifsson G, Hilma H, Riyaz P, Thorarinn G, Gregory T, van Rij AM, Eapen D, Baas AF, Tregouet DA, Morange PE… et al. Population Genomics, deCODE Genetics. Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol. 2012;60:722-9

Herbaux C, Badens C, Guidez S, Lacoste C, Maboudou P, Rose C. A new ATRX mutation in a patient with acquired α-thalassemia myelodysplastic syndrome.Hemoglobin. 2012;36(6):581-5.

Herman JP, Jullien N,Guillen S,Enjalbert A, Pellegrini I, Franc JL Research resource: A genome-wide study identifies potential new target genes for POU1F1. Mol Endocrinol 26 1455-63 2012

Herman SB, Guo T, McGinn DM, Blonska A, Shanske AL, Bassett AS, Chow EW, Bowser M, Sheridan M, Beemer F, Devriendt K, Swillen A, Breckpot J, Digilio MC, Marino B, Dallapiccola B, Carpenter C, Zheng X, Johnson J, Chung J, Higgins AM, Philip N, Simon T, Coleman K, Heine-Suner D, Rosell J, Kates W, Devoto M, Zackai E, Wang T, Shprintzen R, Emanuel BS, Morrow BE; and the International Chromosome 22q11.2 Consortium. Overt cleft palate phenotype and TBX1 genotype correlations in velo-cardio- facial/DiGeorge/22q11.2 deletion syndrome patients. Am J Med Genet A. 2012 Nov;158A(11):2781-7. doi: 10.1002/ajmg.a.35512. Epub 2012 Oct 3.

Hubert L, Panicot-Dubois L, Fallague K, Sabatier F, Dignat-George F, Dubois C. Recruitment of ECFCs at the site of a laser-induced injury is independent of platelet aggregation and fibrin generation. Vascular Pharmacology. Volume : 56. Issue: 5-6; 2012

Jaeger BN, Donadieu J, Cognet C, Bernat C, Ordoñez-Rueda D, Barlogis V, Mahlaoui N, Fenis A, Narni-Mancinelli E, Beaupain B, Bellanné-Chantelot C, Bajénoff M, Malissen B, Malissen M, Vivier E, Ugolini S.Neutrophil depletion impairs natural killer cell maturation, function, and homeostasis.J Exp Med. 2012 Mar 12;209(3):565-80. doi: 10.1084/jem.20111908. Epub 2012 Mar 5



Jaeger BN, Vivier E. Natural killer cell tolerance: control by self or self-control?Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3). doi:pii: a007229. 10.1101/cshperspect.a007229. Review

Jaeger BN, Vivier E. When NK cells overcome their lack of education.J Clin Invest. 2012 Sep 4;122(9):3053-6. doi: 10.1172/JCI63524. Epub 2012 Aug 6

Jaussaud N, Gariboldi V, Grisoli D, Berbis J, Kerbaul F, Riberi A, Collart F.Risk of reoperation for mitral bioprosthesis dysfunction.J Heart Valve Dis. 2012 Jan;21(1):56-60.0.

Javelle E, Oliver M, Savini H, Aubry C, Badens C, Simon F. Severe atazanavir-associated hyperbilirubinemia revealing Canton G6PD deficiency in anAsian HIV-infected patient. AIDS. 2012 Jan 14;26(2):249-51.

Jézéquel P, Campion L, Spyratos F, Loussouarn D, Campone M, Guérin-Charbonnel C, Joalland MP, André J, Descotes F, Grenot C, Roy P, Carlioz A, Martin PM, Chassevent A, Jourdan ML, Ricolleau G. Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study. Int J Cancer. 2012;131:426-37. PMID: 1898387.

Jouanolle AM,Gérolami V,Ged C,Grandchamp B,Le Gac G,Pissard S,Rochette J,Aguilar-Martinez P [Molecular diagnosis of HFE mutations in routine laboratories. Results of a survey from reference laboratories in France].Ann Biol Clin (Paris) 70305-13 2012

Jourde-Chiche N, Daniel L, Chiche L, Burtey S, Mancini J, Jego S, San Marco M, Bardin N. Association between anti-C1q antibodies and glomerular tuft necrosis in lupus nephritis.Clin Nephrol. 2012 Mar;77(3):211-8.

Kadri M, Fabre A, Coze C, Daniel L, Petit P, Sigaudy S, Pinson S, Bouvier C, Delarue A, Fernandez C. Vasoactive intestinal polypeptide-secreting diffuse ganglioneuromatosis affecting the small intestine and the colon in an infant: an exceptional inaugural manifestation of NF1.Ann Pathol. 2012 Feb;32(1):58-64. doi: 10.1016/j.annpat

Kallel C, Cohen W, Saut N, Blankenberg S, Schnabel R, Rupprecht HJ, Bickel C, Munzel T, Tregouet DA, Morange PE. Association of soluble endothelial protein C receptor plasma levels and PROCR rs867186 with cardiovascular risk factors and cardiovascular events in coronary artery disease patients: the Athero Gene study. BMC Med Genet. 2012;8;13:103

Karsenty J,Landrier JF,Rousseau-Ralliard D,Robbez-Masson V,Margotat A,Deprez P,Lechêne P,Grynberg A,Lairon D,Planells R,Gastaldi M Beneficial effects of omega-3 fatty acids on the consequences of a fructose diet are not mediated by PPAR delta or PGC1 alpha. Eur J Nutr 2012 Dec 27. [Epub ahead of print]

Kaspi E, Blot-Chabaud M, George FD, Bardin N. Soluble CD146 and APS: a potentialbiomarker of obstetrical complications? Lupus. 2012 Jun;21(7):779-80.

Kaspi E, Chabaud MB, George FD, Bardin N. Soluble CD146 and APS: a potential biomarker of obstetrical complications? Lupus. 2012 Jun;21(7):779-80.

Kaspi E, Chabaud MB, George FD, Bardin N.Soluble CD146 and APS: a potential biomarker of obstetrical complications?Lupus. 2012 Jun;21(7):779-80. doi: 10.1177/0961203312436864.

Kaspi E, Guillet B, Piercecchi-Marti MD, Alfaidy N, Bretelle F, Bertaud-Foucault A, Stalin J, Rambeloson L, Lacroix O, Blot-Chabaud M, Dignat-George F, Bardin N. Identification of soluble CD146 as a regulator of trophoblast migration: potential role in placental vascular development. Angiogenesis. 2012 Oct 30.



Kervégant M., M. Glaizal, L. Tichadou, M. Hayek-Lanthois, L. de Haro. Risque d’imprégnation par le plomb lors d’usage quotidien de khôl. Presse Méd 2012, 41 : 203 – 4.

Koutbi L, Roussel M, Haïssaguerre M, Deharo JC. Hyperpnea test triggering malignant ventricular arrhythmia in a child with early repolarization.Heart Rhythm. 2012 Jul;9(7):1153-6. doi: 10.1016/j.hrthm.2012.02.022.

Kownacki G., R. Guilhaumou, M. Glaizal, L. Tichadou, H. Hayek-Lanthois, L. de Haro. Persistance sur plusieurs jours de taux élevés de phénytoïne et de symptômes neurologiques au cours d’une intoxication volontaire au Di-hydan*. Thérapie 2012, 67(3) : 267 – 9.

Labadie M., B. Aldabe, N. Ong, A. Joncquiert-Latarjet, V. Groult, A. Poulard, M. Coudreuse, L. Cordier, P. Rolland, P. Chanseau, L. de Haro. Portuguese man-of-war (Physalia physalis) envenomation on the Aquitaine coast of France: an emerging health risk. Clin Toxicol (Phila) 2012, 50(7) : 567 – 70.

Lacroix R, Dignat-George F. Microparticles as a circulating source of procoagulant and fibrinolytic activities in the circulation. Thromb Research. 2012 May;129 Suppl 2:S27-9.

Lacroix R, Dubois C, Panicot-Dubois L, Dignat-George F. Cancer et thrombose physiopathologie : question d’actualité. Quels marqueurs pertinents pour évaluer le risque thrombotique Edition Leo Pharma. 2012

Lacroix R, Judicone C, Poncelet P, Robert S, Arnaud L, Sampol J, Dignat-George F. Impact of pre-analytical parameters on the measurement of circulating microparticles: towards standardization of protocol. J Thromb Haemost. 2012 Mar;10(3):437-46.

Lacroix R, Plawinski L, Robert S, Doeuvre L, Sabatier F, Lizarrondo S, Mezzapesa A, Anfosso F, Leroyer A, Poullin P, Jourde N, Njock M, Boulanger C, Angles-Cano E, and Dignat-George F. Leucocyte and endothelial-derived microparticles : a circulating source for fibrinolysis. Haematologica. 2012 Dec, 97, 1864-72.

Lagier JC., P. Parola, L. de Haro. Une observation d’aranéisme nécrosant évoquant un nouveau cas de loxoscélisme dans le sud de la France. Ann Dermatol Venereol 2012, 139(4) : 293 – 5.

Laine M, Camoin-Jau L, Bessereau J, Sébastien A, Paganelli F, Bonello L. Tailoring antiplatelet therapy: a step toward individualized therapy to improve clinical outcome?. Curr Pharm Des. 2012; 18:5392-401.

Laine M, Doddo Siddo MN, Paganelli F, Dignat-George F, Bonello L. Improved biological efficacy of prasugrel one month after an acute coronary syndrome. Int J Cardiol. 2012 Nov 26.

Laine M, Paganelli F, George FD, Camoin-Jau L, Bonello L. Biological efficacy and clinical safety of a second 600mg loading dose of clopidogrel in elderly patients with high on-treatment platelet reactivity: A pilot study. Int J Cardiol. 2012 ; 165:200-1

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Robert S, Lacroix R, Poncelet P, Harhouri K, Bouriche T, Judicone C, Wischhusen J, Arnaud L, Dignat-George F. High-Sensitivity Flow Cytometry Provides Access to Standardized Measurement of Small-Size Microparticles. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):1054-8.

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Roffino S, Lamy E, Foucault-Bertaud A, Risso F, Reboul R, Tellier E, Chareyre C, Dignat-George F, Simeoni U, Charpiot P. Premature birth is associated with not fully differentiated contractile smooth muscle cells in human umbilical artery. Placenta. 2012 Jun;33(6):511-7.

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Rossi P, Tessonnier L, Frances Y, Mundler O, Granel B.99mTc DPD is the preferential bone tracer for diagnosis of cardiac transthyretin amyloidosis.Clin Nucl Med. 2012 Aug;37(8):e209-10

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Sakr L, Roll P, Payan MJ, Liprandi A, Dutau H, Astoul P, Robaglia-Schlupp A, Loundou A, Barlesi F. Cytology-based treatment decision in primary lung cancer: is it accurate enough? Lung Cancer. 2012 Mar;75(3):293-9.

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Textoris J, Beaufils N, Quintana G, Ben Lassoued A, Zieleskiewicz L, Wiramus S, Blasco V, Lesavre N, Martin C, Gabert J, Leone M. Hypoxia-inducible factor (HIF1α) gene expression in human shock states.Crit Care. 2012 Jul 10;16(4):R120

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CONTRATS ANNÉE 2012

Jacques Albanese Francoise Dignat-George Dr. R. LACROIX - Intérêt pronostique de la balance des activités pro-coagulantes et fibrinolytiques des microparticules dans le choc septique - PHRC interrégional – 2012

Marie-Christine Alessi - Thèse D.GHALOUSSI - Fondation pour la Recherche Médicale -2012 2013 Marie-Christine Alessi - Rôle de la molécule de costimulation CD28 dans le développement de l'état inflammatoire et de la résistance à l'insuline associés à l'obésité - Nouvelles frontières entre immunologie et maladies métaboliques Société Fancophone de Diabète – 2012 2013 Marie-Christine Alessi – ASY - Sanofi Aventis – 2011 2013 Marie-Christine Alessi Pierre Morange - Gene Sequencing - Stago - 2011 2012 Marie-Christine Alessi - Platelet CD40L in atherosclerosis and diabetes - ASTRA ZENECA -2012 2015

Pr Azulay (Marseille)/Pr Simon - Comparaison de 2 stratégies de substitution dopaminergiques chez le Parkinsonien porteur d'une simulation chronique des noyaux sous-thalamique : Aspects cliniques et pharmacologiques – APHM - PHRC multicentrique – 2008 2014 Dr Ben Lassoued Praticien Attaché -Mesures moléculaires de HIF1a chez les brulés à la recherche d’un biomarqueur pour le pronostic de la cicatrisation. (Montant 19 800 euros). (APHM, CHU de Marseille)- AORC -2011- en cours. Caroline Berenguer-Daizé, Pierre-Marie Martin, Kamel Mabrouk, Denis BERTIN, L’Houcine Ouafik. Diagnostic et traitement du cancer androgéno-indépendant. Demande de brevet n°11306438.0 déposée le 4 novembre 2011. Université de Provence AIX-MARSEILLE I.

Pr Bienvenu (Caen)/Pr Simon - Etude du lien entre la pharmacocinétique des corticoïdes et la réponse à la prednisone au cours de la maladie de Horton - CHU Caen - PHRC multicentrique – 2008 2014

Dr Boulamery /Dr GUILHAUMOU - Pharmacocinétique de la lidocaïne après une anesthésie locale tumescente pour mastectomie – APHM – AORC – 2011 2014

Dr Boulamery /Dr Guilhaumou – Pharmacocinétique de la lidocaïne après une anesthésie locale tumescente pour mastectomie – APHM – AORC – 2011 2014 L Bonello V Gerolami - Essai thérapeutique TICAGRELOR- 2012 2013 John Boudjarane - Séquençage ciblé à haut débit des ARN messagers dans le diagnostic des leucémies aigues pédiatriques -AORC junior – 2012

T Brue - Nouveaux déterminants moléculaires des déficits hypophysaires – ANR – 20082013 Dr Brevaut-Malaty (Marseille)/ Dr Boulamery - Tabagisme in utero et marqueurs de sénescence – APHM – AORC – 2012 C Buffat - Effet du poids de naissance et de la croissance post natale sur les maladies cardiovasculaires et métaboliques - Grant Danone institute- 2009 2013 C Buffat - ibu 20/10/10: étude de tolérence et de pharmacogénomique - Oprhan Europe Projet européen – 2010 2012



Mathias Canault Marie-Christine Alessi - Bases cellulaires et moléculaires du risque thrombotique dans l'insulino résistance: étude dans la plaquette - Fondation de France – 2012 2013 Pierre Cau - Vieillissement accéléré, infection par le VIH et traitements anti-rétroviraux - ANRS (2008-2012), SIDACTION (2009-2010). William Cohen - Elaboration d’un score clinico-biologique utilisable à l’échelle individuelle pour estimer le risque thrombotique dans la thrombophilie congénitale - AORC Junior - 2011 2012 Francoise Dignat-George - READ / Control of inter-endothelial junctions integrity by CD146 and JAMs : from molecular basis to renal inflammatory disease- ANR – 2011 2015 Patrice Roll / Francoise Dignat-George - Microparticules, vecteurs d’information génétique au cours de l’infection par le VIH- ANRS – 2011 2012 Francoise Dignat-George - CD 146 et JAMs dans le contrôle de l'intégrité des jonctions endothéliales : des bases moléculaires aux maladies inflammatoires rénales - PRECIPUT -2011 2012 Francoise Dignat-George - CD 146 nouvelle cible dans les pathologies vasculaires – Fondation de France -2012 2014

Pr Dubus (Marseille)/ Dr Boulamery - Biodisponibilité relative du dipropionate de béclométasone chez le nourrisson asthmatique : effet du dispositif d’inhalation et de la taille des particules produites – APHM – AORC - 2012

Francoise Dignat-George / Isabelle Thuret - Etude des microparticules circulantes d'origine érythrocytaire et plaquettaire dans les béta-thalassémies. Impact sur l'état pro-thrombotique et mécanismes de production chez les patients atteints de béta-thalassémies majeures et intermédiaires – PHRC – 2009 2012

C Férec V Gerolami - Hémochromatose de type 4- PHRC Ministère santé – 2010 2012 Dr Guilhaumou (Pharmacologie Médicale) et Dr Francon (IPC) – DOLOSEIN : étude de phase III

prospective randomisée en double aveugle d’une perfusion cicatricielle continue de ropivacaïne versus placebo après mastectomie : réhabilitation après traitement de la douleur post opératoire de l’hôpital au domicile – IPC – Contrats APHM - 2012

R Guieu JC Deharo: role des réce pteurs de l’adénosine dans les syncopes vaso vagales. Bourse de la société francaise de cardiologie Annie Levy-Mozziconacci - Génotypage Rhésus fœtal sur sang maternel, Région PACA. Contrat FIR ARS :

450000 euros. 2010,2011, en cours. Nicolas Levy / Francoise Dignat-George - Progeria : validation de modèles cellulaires et murins de

Progeria et leur tulisation pré-clinique pour le développement d’outils thérapeutiques - ANR – 2009 2012

Kamel Mabrouk, Carine Tesic, Caroline Daizé Berenguer, Denis Bertin, Pierre Marie Martin, L’Houcine Ouafik. Nouvel anticorps anti-peptide, dirigé contre un polypeptide incluant des séquences dérivées de CRLR, RAMP2, RAMP3 et de l’adrénomédulline, anti-angiogénique et son utilisation, notamment dans le cadre du traitement des cancers. PCT number: F2245CAS1FR. CNRS et Université de la Méditerranée.

Pr Mancini (Marseille)/ Dr Boulamery - Effets de la désipramine chez les enfants porteurs du syndrôme de Rett – APHM - PHRC multicentrique – 2009 2014

Centre associé : Pr A. Moncla / Dr C. Missirian . Laboratoire de Génétique Chromosomique, CHU Timone enfants -Caractérisation moléculaire en prénatal par CGH+SNP array des marqueurs chromosomiques surnuméraires et des translocations réciproques apparemment équilibrées de novo . Investigateurs coordonateurs : Dr Patrick CALLIER / Pr Laurence FAIVRE. Service de Cytogénétique, Plateau Technique de Biologie du CHU de Dijon - Etude COMPASS PHRC National 2012

Pierre Morange - LABEX (Marc Lathrop): génétique et thrombose veineuse – LABEX – 2011 2021

Pierre Morange - Research of new variants predisposing venous thrombosis: RENOVA-TV study - APHM PHRC National - 2009 2012



Pierre Morange - Génétique et thrombose veineuse : Van Gogh - Project Ministère des affaires étrangères – 2012 2015 Pierre Morange - Genetic determinants of the Facteur VIII plasma level : how they influence the thrombotic risk - APHM AORC excellence - 2009 2012 Pierre Morange - Activité-FT - Stago – 2011 2012 Laetitia Nee (Marseille)/ audrey Boulamery - Prévention de la FA en post-op de chirurgie cardiaque valvulaire avec CEC : étude randomisée caféine versus placebo – APHM – AORC excellence – 2012 L’Houcine Ouafik, Kamel Mabrouk, Itidal Kaafarani, Pierre Marie Martin. Anticorps anti-peptides se liant aux récepteurs de l’adrénomédulline et leurs utilisations comme médicament. PCT number: n°FR2934597 PCTWO 2010/012911). CNRS et Université de la Méditerranée. PAUL Pascale - Evaluation de la réaction humorale et cellulaire anti-endothéliale dans la survenue du rejet de greffe cardiaque - AAP 2010 Recherche Clinique Translationnelle- 2010 2013 Marjorie Poggi - Convention SEC25L15 2011 - Société Française de Cardiologie - 2011 2012 Cornel Popovici - Implémentation de techniques innovantes dans le diagnostic de routine des leucémies aigües de l’enfant: l’analyse du génome et du transcriptome par puces à ADN. AORC excellence -2012 Patrice Roll - Matrice nucléaire et Cancers : analyses génomique par puces à ADN et protéique des cellules obtenues par ponction pleurale - ARARD (2009-2012) Patrice Roll - Microparticules, vecteurs d’information génétique au cours de l’infection par le VIH? -Contrat d’initiation d’une recherche ANRS (2011-2012) Patrice Roll - Microparticules, vecteurs d’information génétique au cours de l’infection par le VIH? - Projet de recherche ANRS (2012-2013)

Florence Sabatier Franck Paganelli - Intérêt pronostique des marqueurs associés à la modification des progéniteurs endothéliaux au cours de syndromes coronaires aigüs - PHRC interrégional – 2012

Umberto Simeoni/ Florence Sabatier - Encéphalopathie anoxo-ischémique néonatale : étude de la tolérance et de la faisabilité d’un traitement curatif par les cellules souches du sang du cordon ombilical – PHRC – 2010 2013

BREVETS ANNÉE 2012

Numéro 1357282 « Méthode de détection de la contamination par un microbe d’un échantillon par

analyse de spectres de masse » (L.Camoin-Jau)

THESES DE DOCTORAT ANNÉE 2012 FABRE Alexandre- Bases moléculaires du syndrome Tricho-Hépato-Entérique- 19 décembre 2012 GARGNE O - Adaptation cardiovasculaire à l’immersion - décembre 2012 HUBERT Lucas - Progéniteurs endothéliaux : étude des mécanismes de recrutement en situation physiopathogique - décembre 2012 KASPI Elise-Implication de CD146 soluble sur les capacités invasives des trophoblastes. CD146 soluble et auto-anticorps anti-CD146 dans la sclérodermie - 17 décembre 2012



LIGI Isabelle - Caractérisation des composants de la fonction endothéliale au cours du développement normal et pathologique. Implications sur la programmation précoce du risque cardio-vasculaire - Oct 2012 MARSOT Amélie - Pharmacocinétique de population chez les nouveau-nés et jeunes enfants : Vers un modèle optimal pour la vancomycine et le phénobarbital – 18/12/2012 NGUYEN Karine, Exploration génomique du locus FSHD impliqué dans la Dystrophie Facio-Scapulo Humérale par peignage moléculaire de l'ADN- 13 novembre 2012 PERRIN Sophie -Vieillissement accéléré, infection par le VIH, traitements antirétroviraux - 14 décembre 2012

ROCHE Catherine- Thérapies alternatives des adénomes somatotropes et lactotropes résistants : implication du facteur de transcription pou1f1 et du récepteur sst2- décembre 2012 SARLON Gabrielle - Outils diagnostique et thérapeutique innovants de la dysfonction vasculaire au cours des maladies artérielles périphériques - décembre 2012 TORODOVA Dilyana - Implication de la Fractalkine et des Anticorps dans l’Activation cytotoxique des cellules NK ciblant l’Endothélium et les Progéniteurs endothéliaux en Transplantation rénale - Mars 2012


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POLE HOSPITALIER BIOLOGIE - medecine.univ-amu.fr · INTITULÉ : Service de Biochimie Hôpital de la Conception, ... the intestinal microbiome and metabolism in mice. Microb Pathogenesis