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Pôle hospitalier. Biologie 1/21 Mise à jour : janvier 2015 POLE HOSPITALIER BIOLOGIE CHEF DE PÔLE : Professeur Bruno LACARELLE ADRESSE : Hôpital de la Timone - Service de Pharmacocinétique et Toxicologie 264 Rue Saint-Pierre 13385 MARSEILLE Cedex 5 TELEPHONE : 04.91.38.75.65 COURRIEL : [email protected] RATTACHEMENTS : AP-HM DISCIPLINES D’APPARTENANCES : Biochimie et Biologie Moléculaire, Hématologie, Immunologie, génétique, Biologie Cellulaire, Pharmacologie, Toxicologie, Oncologie SPECIALITÉS : Biochimie et Biologie Moléculaire, Hématologie, Immunologie, Génétique, Biologie Cellulaire, Pharmacologie, Toxicologie, Oncologie EFFECTIFS Enseignants-Chercheurs (PU-PH, MCU-PH, CCA, AHU) : 32,79 ETP Personnel Hospitalier (PH, Attaché) : 49,04 ETP (PC, Assistant) 2,80 ETP Personnel Technique (Encadrement) : 14,00 ETP (Techniciens de Laboratoire) : 249,50 ETP (Ingénieurs) : 31,90 ETP (Aide de Laboratoire – AEQ & Divers) : 36,80 ETP Personnel Administratif : 44,70 ETP Internes : 48,60 ETP Etudiants : 75,00 ETP PERSONNELS RATTACHÉS A UNE EQUIPE DE RECHERCHE INSERM UMR 911 CRO2 EQUIPE 4 L Ouafik (PU-PH) INSERM UMR 911 CRO2 B Lacarelle (PU-PH) C Solas (MCU-PH) Suzanne Monjanel (MCU-Attaché) J Ciccolini (MCU-Attaché) UMR NORT inserm 1062, inra 1260 Marie-Christine Alessi (PU-PH) Pierre- Emmanuel Morange (PU-PH) Michel Fontes (PU-PH) Henri Portugal (PU-PH) Marie-Françoise Aillaud (MCU-PH) Véronique Baccini (MCU-PH) Alain Margotat (MCU-PH) Richard Planells (MCU-PH)

POLE HOSPITALIER BIOLOGIE - medecine.univ-amu.fr · Pôle hospitalier. Biologie 2/21 Mise à jour : janvier 2015 Alain Nicolay (MCU-PH) Marguerite Gastaldi (MCU-PH) Catherine Defoort

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Pôle hospitalier. Biologie 1/21

Mise à jour : janvier 2015

POLE HOSPITALIER BIOLOGIE

CHEF DE PÔLE : Professeur Bruno LACARELLE ADRESSE : Hôpital de la Timone - Service de Pharmacocinétique et Toxicologie

264 Rue Saint-Pierre 13385 MARSEILLE Cedex 5

TELEPHONE : 04.91.38.75.65

COURRIEL : [email protected]

RATTACHEMENTS : AP-HM

DISCIPLINES D’APPARTENANCES : Biochimie et Biologie Moléculaire, Hématologie, Immunologie, génétique, Biologie Cellulaire, Pharmacologie, Toxicologie, Oncologie

SPECIALITÉS : Biochimie et Biologie Moléculaire, Hématologie, Immunologie, Génétique, Biologie Cellulaire, Pharmacologie, Toxicologie, Oncologie

EFFECTIFS

Enseignants-Chercheurs (PU-PH, MCU-PH, CCA, AHU) : 32,79 ETP

Personnel Hospitalier (PH, Attaché) : 49,04 ETP (PC, Assistant) 2,80 ETP

Personnel Technique (Encadrement) : 14,00 ETP (Techniciens de Laboratoire) : 249,50 ETP

(Ingénieurs) : 31,90 ETP (Aide de Laboratoire – AEQ & Divers) : 36,80 ETP

Personnel Administratif : 44,70 ETP

Internes : 48,60 ETP Etudiants : 75,00 ETP

PERSONNELS RATTACHÉS A UNE EQUIPE DE RECHERCHE

INSERM UMR 911 CRO2 EQUIPE 4 L Ouafik (PU-PH)

INSERM UMR 911 CRO2 B Lacarelle (PU-PH) C Solas (MCU-PH)

Suzanne Monjanel (MCU-Attaché) J Ciccolini (MCU-Attaché)

UMR NORT inserm 1062, inra 1260

Marie-Christine Alessi (PU-PH) Pierre-Emmanuel Morange (PU-PH) Michel Fontes (PU-PH) Henri Portugal (PU-PH)

Marie-Françoise Aillaud (MCU-PH) Véronique Baccini (MCU-PH) Alain Margotat (MCU-PH) Richard Planells (MCU-PH)

Pôle hospitalier. Biologie 2/21

Mise à jour : janvier 2015

Alain Nicolay (MCU-PH)

Marguerite Gastaldi (MCU-PH)

Catherine Defoort (MCU-PH) Alain Nicolay (MCU-PH) M Gastaldi (MCU-PH) A Margotat (MCU-PH) Charlotte Grosdidier (AHU)

Agathe Henneuse (AHU) UMR MD2 R Guieu (PU-PH)

PJ Lejeune (MCU-PH) G Mottola (MCU-PH) J Fromonot (AHU)

INSERM UMR_S910 Nicolas Lévy (PU-PH) Catherine Badens (PU-PH)

Christophe Beroud (PU-PH) Pierre Cau (PU-PH) Nicole Philip (PU-PH)

Martin Krahn (MCU-PH) Karine Nguyen (MCU-PH) Patrice Roll (MCU-PH) Andrée Robaglia-Schlupp (MCU-PH) Rafaelle Bernard (PH) Nathalie Bonello-Palot (PH)

Annachiara De Sandre-Giovanolli (PH) Sabine Sigaudy (PH) Elise Kaspi (AHU) Nathalie Banzet (Ingénieur AP-HM)

Inserm U1076 Nathalie Bardin (MCU-PH)

Inserm U1067/CNRS U7333 Pierre Bongrand (PU-PH) Philippe Robert (MCU-PH) Joanna Vitte (MCU-PH)

Cnrs U7286 José Boucraut (MCU-PH)

CNRS U 7259 Sophie Desplat-Jego (MCU-PH)

Inserm U1104/CNRS U7280 Eric Vivier (PU-PH) Frédéric Vely (MCU-PH)

CRN2M, UMR 7286 Alain Enjalbert (PU-PH) Anne Barlier (PU-PH)

Amapola Autillo-Touati (PU-PH) Jean-Louis Berge Lefranc (MCU-PH) A Saveanu (MCU-PH)

INSERM 1072 Jean Gabert (PU-PH) Annie Lévy-Mozziconnacci (MCU-PH)

UMR 1076 Françoise Dignat-George (PU-PH) Florence Sabatier (PU-PH)

Pôle hospitalier. Biologie 3/21

Mise à jour : janvier 2015

Romaric Lacroix (MCU-PH)

Pascale Paul Sylvie Cointe

SERVICES HOSPITALIERS

INTITULÉ : Service de Transfert d’Oncologie Biologique RESPONSABLE : Pr L’Houcine OUAFIK DISCIPLINE : Oncologie Biologique

INTITULÉ : Département de Génétique Médicale RESPONSABLE : Pr Nicolas LEVY DISCIPLINE : Génétique

INTITULÉ : Service de Biologie Cellulaire RESPONSABLE : Dr Patrice ROLL DISCIPLINE : Biologie Cellulaire

INTITULÉ : Laboratoire d'Immunologie RESPONSABLE : Pr Pierre BONGRAND DISCIPLINE : Immunologie

INTITULÉ : Laboratoire de Biochimie

RESPONSABLE : Pr Henri PORTUGAL DISCIPLINE : Biochimie

INTITULÉ : Laboratoire de Biochimie et Biologie Moléculaire RESPONSABLE : Pr Régis GUIEU DISCIPLINE : Biochimie

INTITULÉ : Biochimie et Biologie Moléculaire. RESPONSABLE : Pr Jean GABERT DISCIPLINE : Biochimie et Biologie Moléculaire

INTITULÉ : laboratoire de Biologie Moléculaire, Hôpital de la Conception

RESPONSABLE : Pr Alain ENJALBERT DISCIPLINE : Biologie Moléculaire

INTITULÉ : Service d’Hématologie et de Biologie Vasculaire RESPONSABLE : Pr Françoise DIGNAT - GEORGE DISCIPLINE : Hématologie, Immunologie, Biologie Vasculaire

INTITULÉ : Pharmacocinétique et toxicologie RESPONSABLE : Pr Bruno LACARELLE DISCIPLINE : Pharmacocinétique, Toxicologie

INTITULÉ : Service d’Hématologie Hôpital Nord et Hôpital de la Timone RESPONSABLE : Pr Pierre-Emmanuel MORANGE DISCIPLINE : Hématologie

INTITULÉ : Service de Pharmacologie Clinique Hôpital de la Timone et Hôpitaux Sud RESPONSABLE : Pr Olivier BLIN DISCIPLINE : Pharmacologie

INTITULÉ : Service Pharmacologie Clinique CAP Hôpitaux Sud RESPONSABLE : Pr Nicolas SIMON DISCIPLINE : Pharmacologie

Pôle hospitalier. Biologie 4/21

Mise à jour : janvier 2015

PUBLICATIONS ANNÉE 2013

1 Abaeva AA, Canault M, Kotova YN, Obydennyy SI, Yakimenko AO, Podoplelova NA, Kolyadko VN,

Chambost H, Mazurov AV, Ataullakhanov FI, Nurden AT, Alessi MC, Panteleev MA. Procoagulant platelets form anα-granule protein-covered 'cap' on their surface that promotes their attachment to aggregates. J Biol Chem. 2013;288:29621-32 (IF = 4.651)

2

Ambrosi P, Kreitmann B, Cohen W, Habib G, Morange P Anticoagulation with a new oral anticoagulant in heart transplant recipients.Int J Cardiol. 2013;168:4452-3 (IF = 6.175)

3 Amiot MJ, Romier B, Dao TM, Fanciullino R, Ciccolini J, Burcelin R, Pechere L, Emond C, Savouret

JF, Seree E. Optimization of trans-Resveratrol bioavailability for human therapy. Biochimie. 2013 Jun;95(6):1233-8.

4 André F, Ciccolini J, Spano JP, Penault-Llorca F, Mounier N, Freyer G, Blay JY, Milano G.

Personalized medicine in oncology: where have we come from and where are we going? Pharmacogenomics. 2013 Jun;14(8):931-9. doi: 10.2217/pgs.13.79.

5

Ayach L, Curti C, Montana M, Pisano P, Vanelle P. Actualités dans le traitement étiologique de la sclérose latérale amyotrophique. Amyotrophic lateral sclerosis: Update on etiological treatment Thérapie. Vol. 68, No. 2 (Mars-Avril 2013) : 93

6

Bakour S, Touati A, Sahli F, Ameur AA, Haouchine D, Rolain JM. Antibiotic resistance determinants of multidrug-resistant Acinetobacter baumannii clinical isolates in Algeria. Diagn Microbiol Infect Dis. 2013 Aug;76(4):529-31.

7

Barbieri F, Albertelli M, Grillo F, Mohamed A, Saveanu A, Barlier A, Ferone D, Florio T. Neuroendocrine tumors: insights into innovative therapeutic options andrational development of targeted therapies. Drug Discov Today. 2013 Oct 27. piiS1359-6446(13)00382-6. doi: 10.1016/j.drudis.2013.10.015. [Epub ahead of print] PubMed PMID: 24171952.

8

Barbolosi D, Ciccolini J, Meille C, Elharrar X, Faivre C, Lacarelle B, André N, Barlesi F. Metronomics chemotherapy: time for computational decision support. Cancer Chemother Pharmacol. 2014 Sep;74(3):647-52.

9 Barlesi F, Tomasini P, Fina F, Secq V, Greillier L, Nanni-Metellus I, Garcia S, Ouafik L. Regional molecular genetics centers in thoracic oncology: what and who should be tested?. Bull Cancer. 2013;100:737-41. Ait-Belkacem R, Calligaris D, Sellami L, Villard C, Granjeaud S, Schembri T, Berenguer C, Ouafik L, Figarella-Branger D, Chinot O, Lafitte D. Tubulin isoforms identified in the

brain by MALDI in-source decay. J Proteomics. 2013;79:172-9.

10 Baujat G, Huber C, El Hokayem J, Caumes R, Do Ngoc Thanh C, David A, Delezoide AL, Dieux- Coeslier A, Estournet B, Francannet C, Kayirangwa H, Lacaille F, Le Bourgeois M, Martinovic J, Salomon R, Sigaudy S, Malan V, Munnich A, Le Merrer M, Le Quan Sang KH, Cormier-Daire V.Asphyxiating thoracic dysplasia: clinical and molecular review of 39 families. J Med Genet. 2013

Feb;50(2):91-8

11

Baumstarck K, Bonello L, Dignat-George F, Sabatier F.Mobilization of CD34+KDR+ endothelial

progenitor cells predicts target lesion revascularization: a reply to a rebuttal concerning power and sample size calculation. J Thromb Haemost. 2013 Feb;11(2):398-9.

12

Ben Lassoued A1, Beaufils N, Dales JP, Gabert J. Hypoxia-inducible factor-1α as prognostic marker. Expert Opin Med Diagn. 2013 Jan;7(1):53-70.

Pôle hospitalier. Biologie 5/21

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13 Berenguer-Daizé C, Boudouresque F, Bastide C, Tounsi A, Benyahia Z, Acunzo J, Dussault N,

Delfino C, Baeza N, Daniel L, Cayol M, Rossi D, El Battari A, Bertin D, Mabrouk K, Martin PM,

Ouafik L. Adrenomedullin blockade suppresses growth of human hormone-independent prostate tumor xenograft in mice. Clin Cancer Res. 2013; 19(22):6138-50. Nouguerède E, Berenguer C,

Garcia S, Bennani B, Delfino C, Nanni I, Dahan L, Gasmi M, Seitz J-F, Martin P-M, Ouafik L. Expression of Adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenografts growth in vivo. Cancer Medicine. 2013; 2(2):196-207.

14

Bertin D, Grimaud JC, Lesavre N, Benelmouloud C, Desjeux A, Garcia S, et al. Targeting tissular immune response improves diagnostic performance of anti-Saccharomyces cerevisiae antibodies (ASCA) in Crohn's disease. PLoS One 2013;8:e80433.

15 Bertin D, Jourde-Chiche N, Bongrand P, Bardin N. Original approach for automated quantification of antinuclear autoantibodies by indirect immunofluorescence. Clin Dev Immunol 2013;2013:182172.

16

Bertin D, Jourde-Chiche N, Bongrand P, Bardin N. Original approach for automated quantification of antinuclear autoantibodies by indirect immunofluorescence. Clin Dev Immunol. 2013 ; 2013 :

182 172. doi: 10.1155/2013/182172. Epub 2013 Dec 18.

17 Bertin D, Stephan D, Khrestchatisky M, Desplat-Jégo S. Is TWEAK a Biomarker for

Autoimmune/Chronic Inflammatory Diseases? Front Immunol 2013;4:489.

18

Bessoles S, Angelov GS, Back J, Leclercq G, Vivier E, Held W. Education of murine NK cells requires both cis and trans recognition of MHC class I molecules. J Immunol 2013;191:5044-51.

19

Biroccio A, Cherfils-Vicini J, Augereau A, Pinte S, Bauwens S, Ye J, et al. TRF2 inhibits a cell- extrinsic pathway through which natural killer cells eliminate cancer cells. Nat Cell Biol 2013;15:818-28.

20 Blons H, Rouleau E, Charrier N, Chatellier G, Côté JF, Pages JC, de Fraipont F, Boyer JC, Merlio JP, Morel A, Gorisse MC, de Cremoux P, Leroy K, Milano G, Ouafik L, Merlin JL, Le Corre D,

Aucouturier P, Sabourin JC, Nowak F, Frebourg T, Emile JF, Durand-Zaleski I, Laurent-Puig P; MOKAECM Collaborative Group. Performance and cost efficiency of KRAS mutation testing for

metastatic colorectal cancer in routine diagnosis: the MOKAECM study, a nationwide experience. PLoS One. 2013;8(7):e68945.

21 Bonello L, Frère C, Paganelli F, Laine M. The impact of the environment on diseases and drugs. J Am Coll Cardiol. 2013 Aug 6;62(6):513-5.

22 Bonello L, Laine M, Baumstarck K, Fernandez J, Maillard L, Peyrol M, Bessereau J, Aradi D, Camilleri E, Roubille F, Piot C, Paganelli F, Camoin-Jau L, Dignat-George F. A randomized trial of platelet reactivity monitoring-adjusted clopidogrel therapy versus prasugrel therapy to reduce high on-treatment platelet reactivity. Int J Cardiol. 2013 Oct 9;168(4):4244-8.

23

Bonello L, Laine M, Kipson N, Mancini J, Helal O, Fromonot J, Gariboldi V, Condo J, Thuny F, Frere C, Camoin-Jau L, Paganelli F, Dignat-George F, Guieu R. Ticagrelor increases adenosine plasma concentration in patients with an acute coronary syndrome. J Am Coll Cardiol. 2014 Mar 11;63(9):872-7. doi: 10.1016/j.jacc.2013.09.067. Epub 2013 Nov 27. PubMed PMID: 24291273.

24 Bonello L, Paganelli F, Laine M. Pharmacological interactions: the next frontier ? JACC Cardiovasc Interv. 2013 Feb;6(2):180-1.

25

Bordignon B, Chiron J, Fontés M. Ascorbic acid derivatives as a new class of antiproliferative molecules.Cancer Lett. 2013;338:317-27 (IF = 4.258)

26 Bordignon B, Mones S, Rahman F, Chiron J, Peiretti F, Vidal N, Fontes M. A derivative of ascorbic

acid modulates cAMP production. Biochem Biophys Res Commun. 2013;439:137-41 (IF = 2.406)

27

Boubred F, Saint-Faust M, Buffat C, Ligi I, Grandvuillemin I, Simeoni U. Developmental Origins of Chronic Renal Disease: An Integrative Hypothesis. Int J Nephrol. 2013;2013:346067. Epub 2013 Aug 29.

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28 Bourgeois C, Douplat M, Guieu R, Pradel V, Fromonot J, Bonnet JL, Alazia M. [Interest of the

combination of high-sensitivity troponine and copeptin in diagnosis of non ST elevation myocardial

infarction]. Ann Biol Clin (Paris). 2013 Sep-Oct;71(5):545-54.

29 Bricaire L, Odou MF, Cardot-Bauters C, Delemer B, North MO, Salenave S, Vezzosi D, Kuhn JM, Murat A, Caron P, Sadoul JL, Silve C, Chanson P, Barlier A, Clauser E, Porchet N, Groussin L; GTE Group. Frequent large germline HRPT2deletions in a French National cohort of patients with primaryhyperparathyroidism. J Clin Endocrinol Metab. 2013 Feb;98(2):E403-8. doi:

10.1210/jc.2012-2789. Epub 2013 Jan 4. Erratum in: J Clin Endocrinol Metab. 2013 Apr;98(4):1766. PubMed PMID: 23293331.

30

Brodovitch A, Bongrand P, Pierres A. T lymphocytes sense antigens within seconds and make a decision within one minute. J Immunol 2013;191:2064-71.

31

Broucqsault N1, Morere J, Gaillard MC, Dumonceaux J, Torrents J, Salort-Campana E, Maues De Paula A, Bartoli M, Fernandez C, Chesnais AL, Ferreboeuf M, Sarda L, Dufour H, Desnuelle C, Attarian S, Levy N, Nguyen K, Magdinier F, Roche S.Dysregulation of 4q35- and muscle-specific genes in fetuses with a short D4Z4 array linked to facio-scapulo-humeral dystrophy.Hum Mol

Genet. 2013 Oct 15;22(20):4206-14.

32 Busa T, Chabrol B, Perret O, Longy M, Philip N. Novel PTEN germline mutation in a family with mild phenotype: difficulties in genetic counseling. Gene. 2013 Jan 10;512(2):194-7. doi:

10.1016/j.gene.2012.09.134. Epub 2012 Nov 2. PubMed PMID: 23124040.

33 Cacciagli P, Sutera-Sardo J, Borges-Correia A, Roux JC, Dorboz I, Desvignes JP, Badens C, Delepine M, Lathrop M, Cau P, Lévy N, Girard N, Sarda P, Boespflug-Tanguy O, Villard L.

Mutations in BCAP31 cause a severe X-linked phenotype with deafness, dystonia, and central hypomyelination and disorganize the Golgi apparatus. Am J Hum Genet. 2013 Sep 5;93(3):579- 86.

34

Calfee MW, Rose LJ, Morse S, Mattorano D, Clayton M, Touati A, Griffin-Gatchalian N, Slone C, McSweeney N. Comparative evaluation of vacuum-based surface sampling methods for collection of Bacillus spores. J Microbiol Methods. 2013 Dec;95(3):389-96.

35 Callier P, Aral B, Hanna N, Lambert S, Dindy H, Ragon C, Payet M, Collod-Beroud G, Carmignac V,

Delrue M, Goizet C, Philip N, Busa T, Dulac Y, Missotte I, Sznajer Y, Toutain A, Francannet C, Megarbane A, Julia S, Edouard T, Sarda P, Amiel J, Lyonnet S, Cormier-Daire V, Gilbert B, Jacquette A, Heron D, Collignon P, Lacombe D, Morice-Picard F, Jouk P, Cusin V, Willems M, Sarrazin E, Amarof K, Coubes C, Addor M, Journel H, Colin E, Khau Van Kien P, Baumann C, Leheup B, Martin-Coignard D, Doco-Fenzy M, Goldenberg A, Plessis G, Thevenon J, Pasquier L, Odent S, Vabres P, Huet F, Marle N, Mosca-Boidron A, Mugneret F, Gauthier S, Binquet C, Thauvin-Robinet C, Jondeau G, Boileau C, Faivre L. Systematic molecular and cytogenetic

screening of 100 patients with marfanoid syndromes and intellectual disability. Clin Genet. 2013 Mar 18. doi: 10.1111/cge.12094. [Epub ahead of print] PubMed PMID: 23506379.

36

Carrieri MP, Lions C, Sogni P, Winnock M, Roux P, Mora M, Bonnard P, Salmon D, Dabis F, Spire B; ANRS CO13 HEPAVIH Study Group. Association between elevated coffee consumption and daily chocolate intake with normal liver enzymes in HIV-HCV infected individuals: results from the ANRS CO13 HEPAVIH cohort study. J Hepatol. 2014 Jan;60(1):46-53. doi:

10.1016/j.jhep.2013.08.014. Epub 2013 Aug 24.

37

Cayla G, Cuisset T, Silvain J, O'Connor SA, Kerneis M, Castelli C, Quilici J, Bonnet JL, Alessi MC, Morange PE, Collet JP, Montalescot G. Prasugrel monitoring and bleeding in real world patients. Am J Cardiol. 2013;11138-44. (IF = 3.425)

38

Cayla G, Morange PE, Chambost H, Schved JF. Management of cardiovascular disease in haemophilia.Thromb Res. 2013;132:8-14 (IF = 2.372)

39

Chabbert-Buffet N, Guigues B, Trillot N, Biron C, Morange P, Pernod G, Scheffler M, Brugere S, Hedon B. [DVT and combined oral contraceptives: update of the pluridisciplinary CNGOF-FNCGM- GEHT-SFMV group].J Gynecol Obstet Biol Reprod (Paris). 2013;42:309-15 (IF = 0.448)

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40 Chassaing N1, Causse A, Vigouroux A, Delahaye A, Alessandri JL, Boespflug-Tanguy O, Boute- Benejean O, Dollfus H, Duban-Bedu B, Gilbert-Dussardier B, Giuliano F, Gonzales M, Holder-

Espinasse M, Isidor B, Jacquemont ML, Lacombe D, Martin-Coignard D, Mathieu-Dramard M, Odent S, Picone O, Pinson L, Quelin C, Sigaudy S, Toutain A, Thauvin-Robinet C, Kaplan J, Calvas P. Molecular findings and clinical data in a cohort of 150 patients with anophthalmia/microphthalmia.Clin Genet. 2013 Sep 10.

41

Ciccolini J, Fanciullino R, Milano G. Predicting survival of gastric cancer patients treated with 5- fluorouracil-based regimen: falling again on TP53 Pharmacogenomics 07/2013; 14(10):1137- 1138.

42

Ciccolini J, Peters GJ, Giovannetti E. Gender, cytidine deaminase, and 5-aza/decitabine--letter. Clin Cancer Res. 2013 Jun 1;19(11):3105.

43

Colson P, Bregigeon S, Tourres C, Solas C, Poizot-Martin I, Tamalet C. Relapse of hepatitis C virus after 14 months of sustained virological response following pegylated-interferon alpha plus ribavirin therapy in a human immunodeficiency virus type 1 infected patient. J Clin Virol. 2013 Sep;58(1):309-14.

44 Cordier C, Taris N, De Pauw A, Sobol H, Philip N, Voelckel MA. French professionals in genetic counselor careers. J Genet Couns. 2013 Dec;22(6):844-8. doi: 10.1007/s10897-013-9599-x.

Epub 2013 May 21. PubMed PMID: 23689926.

45 Cottereau E, Mortemousque I, Moizard MP, Bürglen L, Lacombe D, Gilbert-Dussardier B, Sigaudy S, Boute O, David A, Faivre L, Amiel J, Robertson R, Viana Ramos F, Bieth E, Odent S, Demeer B, Mathieu M, Gaillard D, Van Maldergem L, Baujat G, Maystadt I, Héron D, Verloes A, Philip N,

Cormier-Daire V, Frouté MF, Pinson L, Blanchet P, Sarda P, Willems M, Jacquinet A, Ratbi I, Van Den Ende J, Lackmy-Port Lis M, Goldenberg A, Bonneau D, Rossignol S, Toutain A..Phenotypic spectrum of Simpson-Golabi-Behmel syndrome in a series of 42 cases with a mutation in GPC3 and review of the literature. Am J Med Genet C Semin Med Genet. 2013 May;163C(2):92-105

46

Courcet JB, Faivre L, Michot C, Burguet A, Perez-Martin S, Alix E, Amiel J, Baumann C, Cordier MP, Cormier-Daire V, Delrue MA, Gilbert-Dussardier B, Goldenberg A, Jacquemont ML, Jaquette A, Kayirangwa H, Lacombe D, Le Merrer M, Toutain A, Odent S, Moncla A, Pelet A, Philip N, Pinson L,

Poisson S, Kim-Han le QS, Roume J, Sanchez E, Willems M, Till M, Vincent-Delorme C, Mousson C, Vinault S, Binquet C, Huet F, Sarda P, Salomon R, Lyonnet S, Sanlaville D, Geneviève D. Clinical and molecular spectrum of renal malformations in Kabuki syndrome. J Pediatr. 2013 Sep;163(3):742-6. doi: 10.1016/j.jpeds.2013.02.032. Epub 2013 Mar 25. PubMed PMID:

23535010.

47 Cristofaro B, Shi Y, Faria M, Suchting S, Leroyer AS, Trindade A, Duarte A, Zovein AC, Iruela-

Arispe ML, Nih LR, Kubis N, Henrion D, Loufrani L, Todiras M, Schleifenbaum J, Gollasch M, Zhuang ZW, Simons M, Eichmann A, le Noble F. Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development. 2013 Apr;140(8):1720-9.

48 Cuisset T, Grosdidier C, Loundou AD, Quilici J, Loosveld M, Camoin L, Pankert M, Beguin S, Lambert M, Morange PE, Bonnet JL, Alessi MC. Clinical Implications of Very Low On-Treatment platelet reactivity in patients treated with thienopyridine: The POBA study (Predictor of bleedings

with antiplatelet drugs).JACC Cardiovasc Interv. 2013;6:854-63 (IF = 6.552)

49

Cuisset T, Quilici J, Morange PE, Bonnet JL, Alessi MC. Predictors of long-term high on-treatment platelet reactivity in clopidogrel-treated patients undergoing coronary stenting for acute coronary syndrome.Int J Cardiol. 2013 ;168:1565-6. (IF = 6.175)

50

Cuisset T,Cayla G, Quilici J, Pankert M, Deharo P, Bonnet G, Grosdidier C, Beguin S, Morange P, Bonnet JL, Alessi MC.Off-label use of prasugrel in stable coronary artery disease is associated with greater degree of platelet inhibition compared with use after acute coronary syndrome. Int J Cardiol. 2013 ;168:2988-9 (IF = 6.175)

51

Cuny T, Barlier A. The significance of MEN1 mutations in pituitary carcinomas. Biomark Med. 2013 Aug;7(4):567-9. doi: 10.2217/bmm.13.69. PubMed PMID: 23905891.

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52 Cuny T, Pertuit M, Sahnoun-Fathallah M, Daly A, Occhi G, Odou MF, Tabarin A, Nunes ML,

Delemer B, Rohmer V, Desailloud R, Kerlan V, Chabre O, Sadoul JL, Cogne M, Caron P, Cortet-

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CONTRATS ANNÉE 2013 S. ATTARIAN – « Outils pour l’évaluation thérapeutique dans la maladie de Charcot-Marie-Tooth de type IA : critères de jugement et biomarqueurs » - AP-HM – PHRC Inter régional 2013

P. ROLL : « Matrice nucléaire et Cancers : analyses génomique par puces à ADN et protéique des cellules obtenues par ponction pleurale », ARARD (2009-2013)

P. ROLL : « Microparticules, vecteurs d’information génétique au cours de l’infection par le VIH ? », Projet de recherche ANRS (2012-2013)

L. NEE : Effets de la caféine dans le FA post opératoire – AORC-

A. HAUTIER « RECHERCHE DE BIOMARQUEURS INNOVANTS : EXPRESSION DE HIF-1α ET DE SES ISOFORMES DANS LE SANG ET LES TISSUS CUTANES DES GRANDS BRULES » - AORC - Investigateurs associés : Amin BEN LASSOUED et Pr Jean GABERT. Références CPP : 2012-23 / Référence du Comité : 12 49 / Numéro d'identification : 2012-A00644

A. BARLIER/ A. SAVEANU/ A. ENJALBERT : Nouveaux déterminants moléculaires des déficits hypophysaires - ANR 2008-2013

V. GEROLAMI : Essai thérapeutique TICAGRELOR 2012-2013

V. GEROLAMI : Hémochromatose de type 4 - Ministère santé PHRC -2010-2013

A. BARLIER . H. ZATTARA : Séquencage du gène VHL dans les hémangioblastomes, impact psychologique lors de la reconvocation des patients - AORC 2013 - 2013-2014

N. LEVY: Neuromics - CEE FP7-305121 -Nov 2012

N. LEVY: MNH-DECRYPT : Genomics, pathophysiology and therapeutic approaches in a panel of rare genetics diseases mainly affecting muscle, heart and nervous system – AFM- Juin 2010

Pôle hospitalier. Biologie 20/21

Mise à jour : janvier 2015

J. CICCOLINI - « Pharmacocinétique du bévacizumab » Subvention Cancéropôle 2013 J. CICCOLINI - Recherche des effets séquernces anti-angiogéniques/cytotoxiques » Contrat Roche 2013

J. CICCOLINI - « Développement des ANC »Subvention Gefluc 2013

C. DUBOIS -« Rôles des microparticules dans l’initiation et la régulation des processus de thromboses et de métastases » MiniRev – ANR -2009 2013

C. DUBOIS -« Rôle des plaquettes sanguines dans le développement d’une tumeur et la formation de métastases dans un modèle murin du cancer du pancréas » - ARC-2012 2013

U. SIMEONI F. SABATIER - « Encéphalopathie anoxo-ischémique néonatale : étude de la tolérance et de la faisabilité d’un traitement curatif par les cellules souches du sang du cordon ombilical »- PHRC- 2010 2013

B.GRANEL N. BARDIN - « Sclérodermie et marqueurs vasculaires » - AORC Sénior- 2013

J.R. HARLE F. DIGNAT-GEORGE - « Etude de la lésion endothéliale dans la Drépanocytose »- AORC Sénior – 2011 2013

P. PAUL - « Evaluation de la réaction humorale et cellulaire anti-endothéliale dans la survenue du rejet de greffe cardiaque » - AAP 2010 Recherche Clinique Translationnelle -2010 2013

F. DIGNAT-GEORGE - « CD 146 nouvelle cible dans les pathologies vasculaires » -FONDATION DE FRANCE – 2012 2014

C.DUBOIS - « Etude du pouvoir antitumoral du Clopidrogrel dans un modèle murin du cancer du pancréas » - FORMATION RECHERCHE TRANSLATIONNELLE EN CANCEROLOGIE-2009 2013

C.DUBOIS - « Study of the antitumoral effect of Clopidogrel in a mouse model of pancreatic cancer » -

GFTC – 2012 2013 F. DIGNAT-GEORGE - Exploratory assessment of biomarkers in female patients suffering from chronic venous leg ulcer versus control subjects free of leg ulcer - Laboratoire SERVIER- 2013

M.CANAULT /M.C.ALESSI - Bases cellulaires et moléculaires du risque thrombotique dans l'insulino résistance : étude dans la plaquette - Fondation de France – 2012 2013

M.C. ALESSI - Rôle de la molécule de costimulation CD28 dans le développement de l'état inflammatoire et de la résistance à l'insuline associés à l'obésité - Société Fancophone de Diabète- 2012 2013

M.C. ALESSI - Subvention Annuelle – FRM- 2013

BREVETS ANNÉE 2013

Method for assessing the ability of a patient to respond to or be safely treated by a nucleoside analog based-chemotherapy. Inventeurs : Ciccolini, Mercier, Dahan, Iliadis, Seitz, Ouafik. N° dépôt : US 20130011392 A1. Année de dépôt :2009. Année de publication : 10 janvier 2013. Déposant AMU, co- déposant : AP-HM.

Method for assessing the ability of a patient to respond to or be safely treated by a nucleoside analog based-chemotherapy Brevet - États-Unis US 20130011392 A1 Publié le 10 janvier 2013

Développement d’un système de lecture automatisé. Bertin D, Bongrand P, Bardin N. European patent n°

1000191432. 2013. AP-HM.

Pôle hospitalier. Biologie 21/21

Mise à jour : janvier 2015

THESES DE DOCTORAT ANNÉE 2013

Mathey-Turba Camille –« « JAK2 et syndromes myeloproliferatifs : comparaison de méthodes diagnostiques » - 18 janvier 2013.

Franceschi Frédéric « Contribution à l’étude du système adénosinergique en pathologie cardiovasculaire » - 22 Février 2013

Bennis Youssef . L'érythropoïétine, agent d'optimisation de la thérapie cellulaire par progéniteurs endothéliaux dans l'AVC ischémique et l'ischémie aigüe des membres inférieurs. Mars 2013

Taulelle Jean-Marie – « Quantification de la mutation JAK2 V617 F : Que faire des patients faiblement positifs ? Etude de 165 patients JAK2 V617F positifs entre 2008 et 2010 à l’AP-HM » - 21 juin 2013.

Bonello Nathalie. Conséquences des laminopathies dans l’endothélium vasculaire. Septembre 2013

Favier Marie. Pathologies plaquettaires héréditaires : caractérisation d’une nouvelle mutation. Septembre

2013 Gravier Gilles « Cinétique des réponses cardiorespiratoires et métaboliques lors d’un exercice incrémentiel maximal chez l’homme » – 18 novembre 2013.

Gondouin Bertrand. Les toxines urémiques provoquent un phénotype procoagulant de l’endothélium par la voie du facteur de transcription AHR. Novembre 2013

Darbousset Roxane. Rôle des polynucléaires neutrophiles dans la formation d'un thrombus in vivo dans un

modèle murin après blessure au rayon laser. Décembre 2013 Amira Mohamed. Nouvelles molécules thérapeutiques en développement pour les Tumeurs Neuroendocrines d’origine gastroentéropancréatiques et hypophysaires: Preuves de concept in vitro dec

2013