Physics, Astrophysics and Applied Physics PhD School

Metabolic radiotherapy

Study and optimization of the production of relevant radionuclides

Simone ManentiR10548-R17

Thuesday, November 18, 2014

Physics, Astrophysics and Applied Physics PhD School

Physics, Astrophysics and Applied Physics PhD school

Applied Physics

Physics for Biomedicine

Physics, Astrophysics and Applied Physics PhD School

Image from http://hyperphysics.phy-astr.gsu.edu/

Physics, Astrophysics and Applied Physics PhD School

Available from: http://www.ncbi.nlm.nih.gov/books/NBK11464/

Physics, Astrophysics and Applied Physics PhD School

Image from: “The Opensource Handbook of Nanoscience and Nanotechnology”

Theranostics:therapy and diagnostics

Physics, Astrophysics and Applied Physics PhD School

Radiochim. Acta, 70-71, Pages 249–272

Characteristics of eligible radionuclides

• half life: few hours (~6) to days (~10)

• a suitable linear energy transfer (LET) value and range in the tissue

• a γ-emission that lays in an energy region suitable for the imaging

• high specific radioactivity (As)“specific activity” is defined as the amount

of radioactivity of the radionuclide of interest per unit mass of all the isotopes

of the radionuclide itself

Physics, Astrophysics and Applied Physics PhD School

M A IN S TE P S

R ad ion u c lid icP u rity

irrad ia tion con d it ion sop tim isa tion

th ick -ta rg e tyie ld s

th in -ta rg e texc ita tion fu n c tion s

N u c lear R eac tionS tu d ies

u ltra -h ig hp u rity eq u ip m en ts

U ltra -h ig hp u rity ta rg e ts

U ltra -h ig hp u rity ch em ica ls

N .C .A .rad ioch em ica l

p rocess in g

C h em ica lP u rity

S p ec ificA c tivity

R ad ioch em ica lP u rity

R ad ion u c lid icP u rity

Q u a lityC on tro l

N.C.A.Labelledcompound

Physics, Astrophysics and Applied Physics PhD School

Experimental procedure

Physics, Astrophysics and Applied Physics PhD School

X-ray and Auger electron emitter: 103Pd

103Pd(d,2n)103Pd

t1/2=16.991 d

electron capture=100%

Eγ=357.45 keV Iγ=0.0221%

Positron, X-ray and Auger electron emitter: 89Zr

89Y(d,2n)89Zr 89Y(p,n)89Zr

t1/2= 78.4 h

electron capture=76.6%

β+=22.3% Emax(β+)=897 keV Eave.(β+)=396.9 keV

Eγ=908.97 keV Iγ=100%

DIGITARE NOME CENTRO

DIGITARE NOME CENTRO

Physics, Astrophysics and Applied Physics PhD School

Thank you for your attention

Grazie per l’attenzione