Nucleus Mar13.pdf

7/29/2019 Nucleus Mar13.pdf

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http://www.nesacs.org

March 2013 Vol. XCI, No. 7

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Monthly MeetingJulius F. Remenar, Alkermes, to speak on Getting

the most from salts and Co-crystals: formulating to

maximize oral absorption

Summer ScholarReport

By Patrick Kelleher, Cameron Hill, Yongli Huang,

Nan Chen, Deno del Sesto, Arthur Utz

International-DomesticStudent Summit

By Justin Foy with photos by Morton Z. Hoffman

January MeetingReport

By Michael P. Filosa, photos by Morton Z. Hoffman


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2 The Nucleus March 2013

The International-Domestic StudentSummit (IDSS) was held in Raleigh,

NC with nine teams of two studentseach (one international and one domes-tic) from universities in the followinglocal sections: Ames, Central NewMexico, Coastal Georgia, Colorado,Dallas-Fort Worth, East Central Illi-

nois, Kansas State Univers ity, NewYork and Northeastern. The purposewas for the ACS to get feedback fromthese students on how to promoteinternational and domestic student col-laboration, increase international skillflow, and utilize the unique resourcesthat the international community pro-vides. A study related to this overarch-ing problem found that 38% of foreignstudents studying in the U.S. did nothave a single close American friend.i

As the largest scientific network, theACS was determined to figure outwhat it was or wasnt doing well inserving of the international student.

I am the domestic student on thisside of the equation. I was raised inConcord, NH and have never reallymoved far from home. The cross-cul-tural friendship statistic surprised mevery much, as did the responses Ireceived when I mentioned it. For

example, one international student inmy department simply said in an apa-thetic tone it can happen. Sure I wasaware that there were cultural barriers

before, but to see such a staggeringnumber and to hear such an attitudeabout the subject was very strange. Istarted realizing that this is a muchlarger problem than I had previouslythought.

My partner to the conference wasmy labmate and friend Xin Su who isfrom Qinhuangdao, China. Xin and Iset out on a brisk November morningfrom the Lebanon, NH airport. Wewere lucky to have perfect weather thatday as we flew out in a small Cessna

pl an e to Bost on and subs eq uent lydown south to Raleigh. We had ourfirst meeting that night at dinner withall of the other teams. This was our

first introduction to Steve Meyers fromthe ACS who had coordinated theevent. It was exciting to meet everyonefor the first time and to see that we hada very diverse group where a good dia-logue on international collaborationcould be formulated.

During the IDSS summit, the par-ticipants were split into three differentgroups to analyze the problem from the

perspective of local institutions, theACS, or the global scientific commu-

Reflecting on the International-

Domestic Student SummitBy Justin Foy (Photos by Morton Z. Hoffman)Department of Chemistry, Dartmouth College, 6128 Burke Hall, Hanover, NH 03755

continued on page 4

Xin Su (at left) with Morton Hoffman (BostonUniversity) and Justin Foy

Graduate students Xin Su (at left) and JustinFoy at their research poster, Activation of

Hydrazone-Based Molecular Switches ThroughCoordination Coupled Proton Transfer


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The Nucleus March 2013 3

The Nucleus is published monthly, except June and August, by the Northeastern Section of the AmericanChemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Textmust be received by the editor six weeks before the date of issue.

Editor: Michael P. Filosa, Ph.D., ZINK Imaging, Inc., 16 Crosby Drive, Building 4G,Bedford, MA 01730 Email: Michael.filosa(at)zink.com; Tel: 508-843-9070

Associate Editors: Myron S. Simon, 20 Somerset Rd., W. Newton, MA 02465, Tel: 617-332-5273,Sheila E Rodman, Email: serodman(at)hotmail.com,Mindy Levine, 516-697-9688, mindy.levine(at)gmail.com

Board of Publications: Mary Mahaney (Chair), Mindy Levine, Vivian K. Walworth

Business Manager: Karen Piper, 19 Mill Rd., Harvard, MA 01451, Tel: 978-456-8622

Advertising Manager: Vincent J. Gale, P.O. Box 1150, Marshfield, MA 02050,Email: Manager-vincegale(at)mboservices.net; Tel: 781-837-0424

Contributing Editors: Morton Hoffman, Feature Editor; Dennis Sardella, Book Reviews

Calendar Coordinator: Sheila Rodman, email: serodman(at)hotmail.com

Photographers: Morton Z. Hoffman and James Phillips

Proofreaders: Donald O. Rickter, Vivian K. Walworth, Mindy Levine

Webmaster: Roy Hagen

Copyright 2013, Northeastern Section of the American Chemical Society, Inc.

The Northeastern Section of the AmericanChemical Society, Inc.

Office: Anna Singer, 12 Corcoran Road,Burlington, MA 01803(Voice or FAX) 781-272-1966.e-mail: secretary(at)nesacs.org

NESACS Homepage:

http://www.NESACS.orgOfficers 2013

ChairLiming Shao158South Great RoadLincoln, MA 01773limingshao(at)comcast.netshao(at)fas.harvard.edu781-518-0720

Chair-ElectCatherine CostelloBoston University School of Medicine670 Albany Street, room 511Boston, MA 02118-2646Cecmsms(at)bu.edu

Immediate Past ChairRuth TannerOlney Hall 415BLowell, MA 01854University of Mass LowellRuth_Tanner(at)uml.edu978-934-3662

Secretary:Michael SingerSigma-Aldrich3 Strathmore Rd, Natick, MA 01360774-290-1391, michael.singer(at)sial.com

Treasurer:James Piper19 Mill Rd, Harvard, MA 01451978-456-3155, piper28(at)attglobal.net

Auditor:Anthony Rosner

ArchivistTim Frigo

Trustees:Peter C. Meltzer, Esther A. H. Hopkins,Michael E. Strem

Directors-at-LargeDavid Harris, Stephen Lantos, James Phillips,Ralph Scannell, Mary Burgess, John Burke

Councilors Alternate Councilors

Term Ends 12/31/2013Alfred Viola Mark FroimowitzMichael Singer Sophia R. SuRobert Lichter Kenneth C. MattesMary Shultz Tim FrigoLeland L. Johnson, Jr. Mukund Chorghade

Term Ends 12/31/2014Katherine Lee C. Jaworek-LopesMichael P. Filosa Lawrence ScottDoris Lewis Andrew Scholte

Morton Z. Hoffman Raj RajurPatrick Gordon John PodobinskiMary Burgess Stuart Levy

Term Ends 12/31/2015Catherine E. Costello Marietta SchwartzRuth Tanner JerryJasinskiDorothy J. Phillips Stephen LantosMichaeline Chen Norton P. PeetJackie ONeil Wilton Virgo

ContentsReflecting on the International-Domestic Student Summit______2

By Justin Foy, Dartmouth College with photos by Morton Z. Hoffman

Monthly Meeting_______________________________________5Julius F. Remenar, Alkermes, Waltham, MA, to speak on Getting the most fromsalts and Co-crystals: formulating to maximize oral absorption

Robert Langer to Receive Major Awards ____________________6

Announcements______________________________________6,7Call for Nominations for the 2013 Theodore William Richards Award for Excel-lence in Teaching Secondary School Chemistry,

Applications wanted for the Norris-Richards Undergraduate Summer ResearchScholarships.

Summer Scholar Report_________________________________8Determination of the Reactivity of the Vibrational Ground State of Methane onNi(111), Patrick Kelleher, Cameron Hill, Yongli Huang, Nan Chen, Deno delSesto, Arthur Utz

January Meeting Report________________________________10By Michael P. Filosa with photos by Morton Z. Hoffman

Central Mass Section Meeting___________________________13

NESACS 2013 Candidates______________________________13

Cover: A photo from the January Meeting held at the Heibert Lounge at Boston

University School of Medicine. (L-R) Liming Shao, 2013 NESACS Chair, RuthTanner, 2012 NESACS Chair, Dr. Allen C. Steere, Harvard Medical School, andCatherine E. Costello, 2013 NESACS Chair-Elect. Photo by Morton Z. Hoffman

Editorial Deadlines: May 2013 Issue: March 15, 2013Summer 2013 Issue: June 15, 2013

Al l Ch ai rs of st an di ngCommittees, the editorof THE NUCLEUS, andthe Trustees of Section

Funds are members of theBoa rd o f Directo rs. AnyCouncilor of the American Chemical Soci-ety residing within the section area is an ex

officio member of the Board of Directors.


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nity. I was assigned to the global scien-tific community group and we tried to

break down the global network into itsrespective institutions such as thefunding agencies, special interestgroups, universities, government,among many others. We began to seethat many of these stakeholders in theglobal network that benefit from inter-national researchers and collaboratorsare poorly coordinated with oneanother. One of the major suggestionswas that the ACS could reach out tothese groups and act as the glue withwhich to build a database of informa-tion to share between the stakeholders.We believe that increasing the net-working ability between communitiesshould also help get more opportuni-ties for international students, whetherit is in the form of discussion groups ata university or getting more out of theembassies.

There were many layers to the dis-cussions that went on during the day.The most interesting part of the discus-sions for me was hearing the stories

from the international students. Sometold sad stories of not being able to gethome for a death in the family becauseof visa difficulties, or some clearlywere set behind in their careers

because of the lack of opportunities intheir home country. It certainly mademe feel lucky to be born in a countrywith such a wealth of opportunity and,furthermore, that there are organiza-tions in this country like the ACS thatare trying to make a difference foreveryone. At the end of the day, all ofthe groups were called together tosummarize their suggestions.

A recurring theme from all of thegroups was the aim to increase the net-working and sharing of informationthrough social media. One area wherethis could be useful would be a blogcontaining societal logistics for acity/state/university (e.g. licensing,

banks, shopping etc.). Another usefulidea was to utilize a network of expa-triates from each region to help mentorincoming students and prepare them

better for the culture here. It was clear

that an increasing amount of attentionshould be given at universities to holdpartnering/mentoring events betweeninternational and domestic students tomake them feel more welcome in thiscountry. An exhaustive report of whatwas discussed is not possible here, butwill be forthcoming from the ACS.

Everyone at the summit realizedthat the common obstacles that divideus, such as fundamental language/cul-tural barriers and visa problems, wouldnot be changed overnight. Nonetheless,

Corporate Patrons$2000 - or moreAstraZeneca Pharmaceuticals

Eisai PharmaceuticalsEMD SeronoGenzyme Corp.

Johnson MattheyMerck & Co.NovartisPfizer Inc.Schering Corp.Strem Chemicals, Inc.Vertex Pharmaceuticals

$1000-$1999Boehringer IngelheimGlaxoSmithKlineIrix PharmaceuticalsLyophilization Services of NESundia Meditech

Yes Bank

$300-$999Cambridge Major LabsGirindusMerrimack ConsultantsOrganixPCI SynthesisSigma AldrichWaters Corp.Wilmington PharmaTech

Student Summitcontinued from page 2

continued on page 12

Justin Foy at his research poster, The Synthesisof Three-Fold Symmetric 1,3,5-tris-Phenylben-

zene Cyclopentadienyl Ligands


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BiographyJules Remenar is a Research Fellow atAlkermes in Watham, MA where his

work is focused on understanding thephysical behavior of drug molecules asthey interact with formulation compo-nents during manufacture, on storage,and after dosing.

Dr. Remenar received a Bachelorsdegree in chemistry from MichiganState University in 1991 and a Ph.D. in

physical-organic chemistry from Cor-nell University in 1996. He completedstudies in polymers and materials sci-ence as a postdoctoral fellow working

jo in tl y be tween the IBM Al maden

Research Center and Stanford.He began his pharmaceutical

career at Merck in Rahway, NJ in1997, moved to Transform Pharmaceu-ticals in 2002, and moved to Alkermesin 2008. At Merck, he was responsiblefor building a new pharmaceuticalchemistry group to support basicresearch activities in Rahway, NJ. AtTransform Pharmaceuticals/J&J he

AbstractGetting the most from salts andCocrystals: formulating tomaximize oral absorption

The delivery, absorption and stabilityof pharmaceuticals is heavily depend-ent on their formulation. A rationalapproach to formulation requires anunderstanding of the physical andchemical properties of the drug itself,the proper selection of additional com-

ponents, and the choice of preparativemethods. Salt formation has been usedwith success, often on a trial-and-error

basis.A promising but so far little under-

stood solution for delivery of poorlysoluble or long-acting drugs involvesthe use of co-crystallization. This lec-ture will present new insights gainedfrom investigation of the chemical,

physical and spectroscopic characteris-

tics of candidate formulations, with thegoal that the well-controlled formationof salts or co-crystallization may beexploited effectively in the design ofnew drugs

The delivery, absorption and sta-bili ty of pharmaceuticals are heavilydependent on their physicochemical

propert ies an d on formula ti on . Arational approach to formulation

begins with a detailed understanding of

the properties of the drug itself.Constructing the relationshipbetween salts, cocrystals, or amorphousphases and the crystalline free formof the molecule is essential for over-coming solubility or dissolution ratelimited absorption. Here, the goal is tochoose forms and formulations that cre-ate and maintain supersaturated solu-tions of the drug. Crystalline salts have

been used with success when the drugmolecule can be easily ionized at phys-iological pH. However, the number of

Monthly MeetingThe 931

st

Meeting of the Northeastern Section of the AmericanChemical Society

Thursday, March 14, 2013

MIT Faculty Club,50 Memorial Drive, Cambridge, MA 02142

4:30 pm Board Meeting

5:30 pm Social Hour

6:30 pm Dinner

7:30 pm WelcomeDr. Liming Shao, Chair, NESACS

SpeakerDr. Julius F. Remenar, Research Fellow, Alkermes, Waltham, MA.Title: Getting the most from salts and Co-crystals: formulating tomaximize oral absorption

Dinner Reservations should be made no later than 12:00 noon, Thursday,March 7th. Reservations are to be made using PayPal services: http://acssym-

posium.com/paypal.html . Select pay with credit or debit card option and followthe additional instructions on the page. Members, $30; Non-members, $35;Retirees, $20; Students, $10, Unemployed $10. Reservations for new membersonly. For additional information contact the secretary, Anna Singer, between 9am and 6 pm at (phone/fax 781-272-1966) or [email protected]. Reserva-tions not canceled at least 24 hours in advance must be paid.THE PUBLIC IS INVITED

continued on page 7



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Robert

Langer toReceiveMajor

AwardsFrom the MIT News Office: http://web.mit.edu/newsoffice/

2013 Wolf PrizeDavid H. Koch Institute Professor

Robert Langer of the MassachusettsInstitute of Technology is among eightrecipients worldwide of the 2013 WolfPrize, the Israel-based Wolf Founda-tion announced.

The prestigious internationalprizes are awarded annually in five cat-egories, each worth $100,000. Morethan 30 Wolf Prize recipi ents havegone on to win the Nobel Prize.

Israeli President Shimon Pereswill present the prizes in May at a spe-cial session hosted by the Knesset, the

Israeli parliament.National Medal of Technology andInnovationRobert Langer is among 23 eminentresearchers nationwide who have beenawarded the nations highest honors,the National Medal for Science and the

National Medal of Technology andInnovation for scientists, engineers andinventors, the White House announced.

Langer, the David H. Koch Insti-tute Professor who won a NationalMedal of Science in 2006 will

receive the National Medal of Technol-ogy and Innovation from PresidentObama at a ceremony to be held laterthis year.

For more detailed reporting see: http://www.boston.com/yourcampus/news/mit/2013/01/mit_professor_to_be_hon-ored_by_president_obama.html

The Richards Award is the most presti-gious award for high school chemistryteaching the Northeastern Section ofthe American Chemical Society offersin recognition of outstanding, innova-tive, and inspired teaching at the sec-ondary level. It is intended to honor a

teacher in the Northeastern Sectionwho, through innovation and dedica-tion, has inspired potential chemists,has communicated chemistry to non-chemists, or has influenced otherteachers of chemistry.

The criteria for excellence corre-spond broadly to the effectiveness withwhich the teacher conveys chemistry,the innovative techniques used to helpstudents comprehend chemical con-cepts, his/her interaction with students,

both academic and extra-cur ricular,

and the influence a teacher has had onother teachers for promoting newapproaches to teaching and learning.

The selected teacher will be offi-

cially honored and will receive both a$1,500 prize and a Certificate ofRecognition at the NESACS Education

Night ceremony in May, 2013.A complete description of the

award, the nomination criteria, andnomination forms can be obtainedfrom the NESACS website at: Nominations are due no laterthan April 15, 2013 to the RichardsAward Committee, attn: Steve Lantos,[email protected] (orvia US Mail to: Steve Lantos, ScienceDepartment, Brookline High School,115 Greenough St, Brookline MA02445)

What exactly goes on at NESACS

monthly Board meetings?

www.nesacs.org/reports

Call for

NominationsThe 2013 Theodore WilliamRichards Award for Excellencein Teaching Secondary SchoolChemistry

Q. Exactly, how many awards and

scholarships does NESACS sponsor?

A) One b) Two c) Many

www.nesacs.org/awards
http://www.boston.com/yourcampus/news/mit/2013/01/mit_professor_to_be_honored_by_president_obama.htmlhttp://www.boston.com/yourcampus/news/mit/2013/01/mit_professor_to_be_honored_by_president_obama.htmlhttp://www.boston.com/yourcampus/news/mit/2013/01/mit_professor_to_be_honored_by_president_obama.htmlhttp://www.boston.com/yourcampus/news/mit/2013/01/mit_professor_to_be_honored_by_president_obama.htmlhttp://www.nesacs.org/curr_events_meetings.htmlhttp://www.nesacs.org/curr_events_meetings.htmlhttp://www.nesacs.org/awards_main.htmlhttp://www.nesacs.org/curr_events_meetings.htmlhttp://www.boston.com/yourcampus/news/mit/2013/01/mit_professor_to_be_honored_by_president_obama.htmlhttp://www.nesacs.org/awards_main.html


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AnnouncementThe Norris-RichardsUndergraduate Summer

Research Scholarships

The Northeastern Section of the Amer-ican Chemical Society established theJames Flack Norris and TheodoreWilliam Richards Undergraduate Sum-mer Scholarships to honor the memo-ries of Professors Norris and Richards

by promoting research interact ionsbetween undergraduate students andfaculty.

Research awards of $3500 will begiven for the Summer of 2013. The

student stipend is $3000 for a mini-mum commitment of ten weeks of full-time research work. The remaining$500 of the award can be spent on sup-

plies, travel, and other items relevantto the student project.

Institutions whose student/facultyteam receives a Norris/RichardsUndergraduate Summer ResearchScholarship are expected to contributetoward the support of the faculty mem-

bers and to waive any student fees forsummer research. Academic credit

may be granted to the students at thediscretion of the institutions.

Award winners are required tosubmit a report (~5-7 double-spaced

pages including figures, tables, andbibliography) of their summer projectsto the NESACS Education Committee

by October 25, 2013 for publication inThe Nucleus. They are also required to

par ticipate in the Northeast StudentChemistry Research Conference(NSCRC) in April 2014.

Applications will be acceptedfrom student/faculty teams at collegesand universities within the Northeast-ern Section. The undergraduate studentmust be a chemistry, biochemistry,chemical engineering, or molecular

biology major in good standing, andhave completed at least two full yearsof college-level chemistry by Summer,2013.

Criteria for Selection:

scientific merit - important factorsinclude the originality of the project,the depth of the investigation, the sig-nificance of the scientific questionsyou pose, and the methods you pro-

pose to use.

feasibility - evidence must be pro-vided to demonstrate that the projectcan be completed by you in the timeavailable and with the facilities at

your disposal. preparation - your academic record,your ability to handle the project, andthe background study you have madeon your research problem will betaken into consideration.

commitment - the depth of yourcommitment, and that of your depart-ment, faculty, and institution to inde-

pendent res ea rch as a vi ta lcomponent of science education will

be assessed.

Completed applications are to be sub-

mitted no later than March 29, 2013,to the Chair of the Selection Commit-tee:Professor Edwin JahngenDepartment of Chemistry, Olney 520University of Massachusetts Lowell1 University AvenueLowell, MA 01854

Notification:Applicants will be notified of theresults by email on April 21, 2013,with written confirmation to follow.

was responsible for improving the oralbioavailability of poorly soluble drugmolecules and avoiding/overcoming

physical and chemical stabili ty prob-lems in drug products. Through thiswork, he became interested in pharma-ceutical co-crystals and in understand-ing where they fit into the spectrum ofdevelopment options. At Alkermes, he

has turned his attention to long-acting,injectable antipsychotics, throughdesign of slowly dissolving crystalline

prodrugs and through the understand-ing of phase behavior within polymericmicrospheres.

Remenar Biographycontinued from page 5


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Introduction:A great deal of the field of chemistry revolves around the

breaking and formation of bonds. The gas-surface dynamicsof heterogeneous catalysis are of particular interest due totheir pervasiveness in technology and chemical industry.Catalysts contribute towards roughly one third of the mate-rial GDP of the US economy1 and also enable the Earth tosustain an additional 3.2 billion people via the ammonia fer-tilizer producing Haber-Bosch process.2 Understandingexactly how the bonds of a gas molecule break in the pres-ence of a metal catalyst would allow us to better predict andcontrol these reactions in order to develop more efficient

processes.Our work focused on the reaction dynamics of methane

on a Ni(111) surface. Methane is the main reagent in thesteam reformation process, which is the source of 95% ofhydrogen gas produced in the United States.3 Methane isalso of great interest from a theoretical standpoint. Its fourdifferent vibrational modes can be accessed with sufficientlylong excited state lifetimes using infrared radiation, makingit ideal for studying the effects of vibrational mode excita-tion on reactivity. Because methane is the simplest alkane, itis also the most basic gas in which C-H bond activation can

be studied. Diatomic gases have only one fundamental

vibrational mode and have been well studied. The vibra-tional modes of more complex polyatomic molecules areoften indiscernible from one another and the mathematicaltools needed to study them have not yet been developed.

Background:Statistical models have often been used to describe the scal-ing of reactivity with total energy. Recent work by the Utzgroup at Tufts University and others have pointed towardsthe existence of mode selective chemistry in which the reac-tivity does not solely depend on how much energy is putinto a system but also how this energy is distributed.4

A prerequisite condition for mode selective chemistry

occurring is that energy redistribution within individualmolecules is sufficiently slower than the reaction time. Mol-ecules that are selectively excited must remain excited longenough to react in order to influence reactivity. This condi-tion being met makes mode selective chemistry possible, butdoes not ensure that it will occur. Late barrier reactionswith geometrically tight transition states provide the bestopportunity for vibrational energy to activate the reagent. Alate transition state more closely resembles the productsand requires a great deal of distortion of the reagents equi-librium geometry. A geometrically tight transition statemeans the activation energy for the reaction increasessharply if the reaction complex varies from the ideal geome-

try. Vibrational modes that distort the molecule to resemble

the transition state will activate the reaction more so thanother modes, producing mode selective behavior.

Figure 1 shows two-dimensional Polanyi diagrams for theadsorption of methane on a surface. The contour lines showequal potential energy, and the saddle point is the energy ofthe transition state. The distance between carbon and hydro-gen is denoted randZis the distance between hydrogen andthe surface. Plot A represents the case where the reaction

barrier, or saddle point, occurs in the translational coordi-

nate (change inZ) before the C-H bond stretches. This is anearly barrier and translational energy would be expectedto be the most effective at promoting reaction. Plot B repre-sents the case where the reaction barrier occurs in the vibra-

Figure 1. Two-dimensional Polanyi diagrams for methaneadsorption.

Figure 2. Sticking curves for ground state and activated

CH4 dissociation on Ni(111).6

Summer Scholar ReportDetermination of the Reactivity of the Vibrational Ground State of Methane on Ni(111)

Patrick Kelleher*, Cameron Hill*, Yongli Huang**, Nan Chen**, Dr. Deno Del Sesto*, Dr. Arthur Utz***Department of Chemistry, Stonehill College, Easton, MA, **Department of Chemistry, Tufts University, Medford, MA


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tional coordinate (change in r) where the C-H bond length isstretched. This is a late barrier and in this case vibrationalenergy would be expected to be the most effective at pro-moting reaction.

The Utz group4 and Beck group5 have performed anumber of previous experiments to measure the reaction

probability of methane on several surfaces. Differing reac-tivity for methane with the same total energy but differentenergetic configurations has been shown, identifying thevibrational modes that best promote transition state accessfor methane dissociation.

Figure 2 shows state-resolved reaction probabilities formethane dissociation on a Ni(111) surface at a surface tem-

perature of 475 K. The f illed in symbols denote reaction

probabilities (black circles), (red squares), and (blue dia-monds). Elevated nozzle temperatures are required to reachEtrans above 75 kJ/mol. Higher nozzle temperatures excitevibrational states in the molecules, which results inenhanced reactivity. This explains the deviation between themeasured S0

Laser Off (open symbols) and the solid curveapproximating S0

--=0. The thermal excitation of vibrationalstates at higher Etrans makes it difficult to interpret how eachstate contributes to the sticking probability. The differencein energy between the v=0 curve and an excited vibrationalstate curve at a specific sticking probability is used to deter-mine the vibrational efficacy. Determining an exact valuefor S0

=0 rather than using a curve to approximate it would

enable us to more accurately calculate the sticking probabil-ity contribution for each vibrational state using Equation 1.

The goal of our research this summer was to experimentallydetermine a value for S0

=0. Sticking curves needed to beprepared for gas mixes with the same kinetic energy but dif-ferent fractions of thermally excited molecules. This can beachieved by mixing methane with lighter or heavier gas to

vary the energy of a molecular beam at a given temperature.The relationship between nozzle temperature and the frac-tion of excited molecules (fexc) follows a Boltzmann distri-

bution. A second plot of sticking probability as a function offexc can then be made by taking vertical slices of the firstplot. Each slice will have a specific kinetic energy and cor-respond to its own curve on the second plot. S0

=0 is thesticking probability of a beam in which all molecules are inthe ground state. By extrapolating to the y-axis (fexc=0) inthe second plot, we can infer the ground state sticking prob-ability at different kinetic energies. A final plot of the stick-ing probability as a function of kinetic energy at fexc=0 willgive us reliable values for S0

=0.

Experimental Procedure:The Ni(111) crystal was cleaned each day by flashing above1000K to bring impurities to the surface, followed by 5 min-utes of argon ion sputtering to remove impurities, and finally

annealing for 15 minutes at 1075K to recover a (111) orderedsurface. Auger electron spectroscopy was used to confirm thesurface was clean. Once cleanliness was verified, the Ni(111)was dosed with a molecular beam. The schematic of themolecular beam apparatus is shown in Figure3. The IR laseris used in mode-selective experiments to excite vibrationalmodes of methane. Our experiment deals only with mole-cules in the ground state, so the laser was not used. The mainchamber has a base pressure of approximately 8x10-11 torrand a pressure with the beam on of approximately 1.7x10 -7

torr.7 After each dose concluded all remaining gas waspumped from the chamber and the QMS was warmed up foranalysis. The Ni(111) surface was exposed to a molecularoxygen beam created by the nozzle. Oxygen dissociates onthe surface, reacting with adsorbed carbon to form COwhich then desorbs. By monitoring the m/z=28 signal, theamount of carbon on the surface can be determined. Thetotal amount of carbon in each dose is dependent on thedose time, flux, and composition of the gas mix used.

Results and Discussion:Several data points were gathered for a nozzle temperatureof 900K. A curve to model the data was created using IGORPro 5.03 software. The data follows a trend that wasexpected based on past studies. Sticking probability dataneeds to be gathered at several different nozzle temperatures(fexc) before further analysis can be carried out as discussedearlier.


Summer Scholarcontinued from page 8

Figure 3. Molecular beam apparatus diagram.


Figure 4. Sticking probabilities for TN=900K.


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January

MeetingA Report by Michael Filosa,Photos by Morton Z. HoffmanIf the January Meeting is a fore-

shadowing, we can expect a very inter-esting year of NESACS monthlymeetings. Cathy Costello, the

NESACS Chair-Elect for 2013 is theprogram chair for 2013. For the firstseminar of the year, she asked herlong-time professional colleague, Dr.Allen C. Steere of Harvard MedicalSchool to speak at our first monthly

meeting of the year about The Eluci-dation of Lyme Disease. The meetingwas hosted in the 14 th floor HiebertLounge at the Boston UniversitySchool of Medicine of which Dr.Costello is a member of the faculty.

AsNucleus editor, I am involvedin the publicizing of meetings and needinformation from the program chair for

publ ication in the Nucleus. As I waswaiting for biographical information, Idecided to Google Dr. Steere and soonfound that although his work is very

well accepted by the scientific andmedical establishment, there is aLyme disease counter culture that ishighly critical of the accepted treatment

protocols for Lyme disease and ques-tion the fundamental science and thehistory of the origins of Lyme disease.

There are a large number ofpatients who believe they suffer fromChronic Lyme Disease and that theyneed to have continuous treatment ofantibiotics to prevent the recurrence ofsymptoms. They claim the bacterium

can adopt a slow-growing form whichhides undetected in the body and burstsforward in a relapse of symptoms(which can be extremely debilitating

and life-threatening) once antibiotictreatment is stopped.There are a number of physicians

and politicians who support thesepa ti en ts and th er e have been lawspassed in a number of states as a con-sequence of their advocacy to allowthese treatments, which in general, arenot supported by the scientific medicalestablishment or the insurance compa-nies that have to pay for these treat-ments.

The scientific consensus is that arelatively long, single or double treat-ment of antibiotics kills the bacteriaand stops the infection. The long-termeffects suffered by some patients are aresult of an auto-immune response to

protein debris from the first infectionor from a reinfection by another tick

bite. Other explanations for the long-term symptoms exhibited by some

patients are chronic fatigue syndrome,fibromyalgia, or psychiatric illnesseswhich are not a consequence of ongo-ing, resistant spirochete infection.

In addition to a history of the elu-cidation of Lyme disease, the recentlydemonstrated inflammatory propertiesof the protein debris from the infecting

bacteria was a significant focus of Dr.Steeres talk to about 50 NESACSmembers at our January Meeting.1

After reading a New York Timesarticle from 2001 entitled Stalking Dr.Steere over Lyme Disease,2 I wasconcerned that this meeting might bedisrupted by the groups critical of Dr.Steeres science. This elicited a sub-stantial discussion before the meetingto make the section leadership awareof the potential for disruption.

I also, because of constraintsposed by the publication deadline ofthe Nucleus, decided unilaterally toleave out the notice that The Public isInvited which has accompanied everymeeting announcement published inth e Nuc le us for as long as I canremember.

The Public is Invited notifica-tion in our meeting notices became asubject of discussion at our board

meeting prior to the evening event. TheNESACS Board voted that the Publicis Invited to all of our monthly meet-ings and struggled to understand what

the concern was for the upcoming talkby Dr. Steere. It was commented thatscience is often controversial.

In the week or so before the meet-ing, announcements of Dr. Steeresupcoming talk were noticed by local(New Hampshire) Lyme diseaseactivists and our secretary was emailedconcerning the controversial natureof his talk and presented referencescounter to Dr. Steeres work.3,4

After dinner, Dr. Steere was intro-duced by Dr. Costello and began histalk. It was a fascinating history aboutLyme disease and its elucidation. Heshowed an idyllic river scene fromLyme, Connecticut and compared it tothe Charles River in Dover, Sherbornand Medfield. He showed a fascinatingmap from the early days in whichLyme disease was discovered and its

primary incidence in the Northeast andMidwest. The markers showing theoccurrences were relatively scatteredwith the majority being in the North-east. Near the end of the talk, heshowed a truly frightening map5pro-duced by the Center of Disease Control(CDC) which showed Lyme diseasehad spread exponentially since the late1970s and now blanketed most of the

Northeast and upper Midwest and hepredicted that the map would be filledin before too long along the GreatLakes including Illinois, Indiana andOhio.

The cause of this spread wasattributed to two factors. Deer were

Boston Skyline as seen from the Hiebert Loungeof the Boston University School of Medicine

Dr. Catherine E. Costello introducing Dr. AllenC. Steere prior to his evening lecture on theElucidation of Lyme Disease.



11/16

hunted to near extinction in the conti-nental US as we entered the 20 th cen-tury. As deer populations have thrived,Lyme disease has returned with avengeance. In addition, a virulent formof theBorrelia burgdorferibacteriumis present in the Northeast which is

particularly prone to induce the severeside-effects of the infection.6

The ancient nature of the diseasewas highlighted by a picture of the ice-man, tzi, the 5300 year-old mummyfound frozen in a melting glacier in theTyrolean Alps in 1991.7.8 tzi wasfound through DNA analysis to havesuffered fromBorrelia infection.

As an example of a consequenceof this inexorable spread, Medfield(the authors home town) created aLyme Disease Advisory Committeea few years ago and started a programat the end of 2011 to cull the deer pop-ulation by bow hunting from its cur-rent 25 per square mile down to a safer7-8 per square mile9.

The highlight of Dr. Steeres talkwas a slide summarizing his collabora-tion with Dr. Costello which identified,

using tandem mass spectrometry, pep-tide factors from patients synovia pro-duced by the infection. These factorswere then synthesized and triggered aninflammatory reaction when reactedwith the matching patients peripheral

blood mononuclear cells. Even in apre- inflammatory state in in fectedpatients these factors were shown tohave an enhanced inflammatory effectwhen compared to control cells fromuninfected subjects.1

After Dr. Steeres initial descrip-

tion of the identification of anunknown tick-borne disease in Lymehe then talked about the difficulty ofidentifying the pathogen. It took anumber of years before reknownedresearcher Willy Burgdorfer was ableto successfully dissectIxodes ticks andshow convincing microscopic evidenceof theBorrelia burgdorferi spirochetein the gut of the ticks. A scanning elec-tron microscopic image of the spiro-chete obtained from one suchdissection was another of the key sci-

entific advances presented by Dr.Steere.

While Dr. Steere was praising theskill and experience of Dr. Burgdorferin identifying the Lyme disease

pathogen through his unparalleled skilland experience, a spectator in the backsuddenly interjected (paraphrasing),But you dont tell the whole story ofhow Burgdorfer in 1952 and 1956 didexperiments to introduceBorrelia intoticks. He was asked to identify him-self. He gave his name, and said hewas a filmmaker exposing the truthabout Lyme disease.

As he was escorted out, he shoutedout a brief verbal attack against Dr.Steere and the effect of Lyme disease

on his family.The rest of the talk proceeded

peacefully. Fortunately, unlike some ofDr. Steeres presentations to Congress,

our meeting was not packed with theopposition desiring to shout him downand contest his science. However,those in attendance did get a flavor ofwhat Dr. Steere has faced the last 20years for sincerely presenting his bestscience as he understands it.

It takes a pretty extreme and cyni-cal view of science and government to

believe that the tick-borne infections inLyme, Connecticut are a product of

biowarfare research gone wrong10 orthat the bulk of scientific presentations

by the establishment are a vast con-spiracy to cover up the truth aboutLyme disease.

Regardless of the exact truthabout Lyme infections, tick-borneinfections byBorre lia burgdorfer ispirochetes are a huge public healthmenace and tick-borne infections must

be deal t wi th aggressively througheducation and reduction of tick popula-tions by a variety of means.

Many thanks to Dr. Steere andCathy Costello for this stimulating and

January MeetingContinued from page 10



Allen Steere (Harvard Medical School) present-ing his talk, "The Elucidation of Lyme Disease."


12/16


Future Work:Due to time constraints and setbackswith the molecular beam apparatusduring the summer we were only ableto construct a curve for one tempera-ture. Future work needs to be done togather data for a range of other nozzletemperatures. Once sufficient data iscollected it can be analyzed as dis-cussed earlier and a curve for S0

=0 as afunction of kinetic energy constructed.

Acknowledgments:I would like to thank the Norris/Richards Undergraduate Summer

Research Scholarship, my advisor, Dr.Deno Del Sesto (Stonehill College),our collaborator Dr. Arthur Utz, Stone-hill SURE Scholar Cameron Hill, andthe Utz Research Group at Tufts Uni-versity including: Eric Dombrowski,Eric Peterson, Nan Chen, and YongliHuang.

References:1 M. E. Davis, D. Tilley, National Sci-

ence Foundation, Washington, DC(2003).

2 V. Smil,Enrich ing the Earth: Fritz

Haber, Carl Bosch, and the Transfor-mation of World Food Production, MITPress, Cambridge, MA (2001).

3 Natural Gas Reforming. FCT Hydro-gen Production:. USDOE, n.d. Web. 13July 2012. .

4 Utz A.l. Mode selective chemistry atsurfaces. Curr. Opin. Solid State Meter.Sci. (2009), doi:10.1016/j.cossms.2009.01.004

5 R. Bisson, M. Sacchi, T.T. Dang, B.Yorder, P. Maroni, R.D. Beck, State-resolved reactivity of CH4 (23) onPt(111) and Ni(111): effects of barrierheight and transition state location,J.

Phys. Chem . A 111 (2007) 12679-12683

6 L.B.F. Juurlink et al., State-resolvedprobes of methane dissociation dynam-ics,Prog. Surf. Sci (2009), doi:10.1016/

j.progsurf.2009.01.0017 McCabe, P. R., L. B. F. Juurlink, and A.

L. Utz. A Molecular Beam Apparatusfor Eigenstate-resolved Studies of Gas-surface Reactivity.Review of Scien-tific Instruments 71.1 (2000): 42.

Summer Scholarcontinued from page 9

we were still hopeful that progresstowards our common goal could bemade through practical suggestions,such as networking between the ACSand these stakeholders as well as mak-ing changes at the local level. All ofthese activities could sow the seeds forchange in the right direction. I didleave the summit optimistic aboutsome of these suggestions that we hadmade and also because of how ourgroup came together. Even without theACS-planned events during the trip,most of our group of international anddomestic students would spend timewith each other every night, going outto dinner and planning our own events.The last night was the best as we allwent out to a couple of different nightclubs in Raleigh. It might be the firstand last time I will ever see more thanten dancing chemists in my life! We allmade some great friends through thisexperience and knew that putting our

best foot forward to discuss a complexproblem was better than being apa-thetic toward the issue and the peoplearound us.

We are especially grateful to theACS and those most involved with usat the summit: Steve Meyers, VarshaRamini, H. N. Cheng and Jodi Wese-mann.

Student Summitcontinued from page 4

Xin Su making his oral presentation, When

Aromaticity Met Resonance-Assisted HydrogenBonding (RAHB): Unusual para-SubstituentEffects on the Intramolecular H-Bond in Hydra-zone-Based switches

i Gareis, E.Journal of Internationaland Intercultural Communication2012

, 5, 309312.

fascinating topic and to Boston Uni-versity School of Medicine for hostingthe first monthly meeting of 2013.

References1 Drouin, Elise E.; Seward, Robert J.; Strle,

Klemen; McHugh, Gail; Katchar,Kianoosh; Londono, Diana; Yao, Chunxi-ang; Costello, Catherine E.; Steere, AllenC. , Ar thri ti s & Rh eumati sm (2013),65(1), 186-196.

2 David Grann,New York Times, June 17,2001. http://www.nytimes.com/2001/06/17/magazine/17LYMEDISEASE.html?pagewanted=all

3 Carl Tuttle, The Lancet Infectious Dis-eases (2012) 12(5), 362. http://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2812%2970054-3/fulltext

4 Raphael B. Stricker, Lorraine Johnson,Future Microbiol. (2012), 7(11) 1243-1246.

5 A 2006 version of the CDC map can beseen at Todars Online Textbook of Bacte-riology,Ahttp://textbookofbacteriology.ne

t/Lyme_2.html6 Borrelia burgdorferi RST1 (OspC typeA) genotype is associated with greaterinflammation and more severe Lyme dis-ease, Strle, Klemen; Jones, Kathryn L.;Drouin, Elise E.; Li, Xin; Steere, Allen C.

American Journal of Pathology (2011),178(6), 2726-2739.

7 Stephen S. Hall,National Geographic ,February 2013. http://ngm.nationalgeographic.com/2011/11/iceman-autopsy/hall-text

8 Ewen Callaway, nature.com, February28, 2012. http://www.nature.com/news/


poorly soluble, difficult to ionize phar-maceutical candidates has increaseddramatically in recent decades, leadingto an explosion of research on cocrys-tals and stable amorphous materials.

This lecture will present newinsights gained from investigating theinteractions between drug moleculesand formulation components duringdissolution and will emphasize theimportance of correlating changes insolubility with the physical form of thedrug.

Remenar AbstractContinued from page 5

http://www.nytimes.com/2001/06/17/magazine/17LYMEDISEASE.html?pagewanted=allhttp://www.nytimes.com/2001/06/17/magazine/17LYMEDISEASE.html?pagewanted=allhttp://www.nytimes.com/2001/06/17/magazine/17LYMEDISEASE.html?pagewanted=allhttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2812%2970054-3/fulltexthttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2812%2970054-3/fulltexthttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2812%2970054-3/fulltexthttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2812%2970054-3/fulltexthttp://textbookofbacteriology.net/Lyme_2.htmlhttp://textbookofbacteriology.net/Lyme_2.htmlhttp://textbookofbacteriology.net/Lyme_2.htmlhttp://ngm.nationalgeographic.com/2011/11/iceman-autopsy/hall-texthttp://ngm.nationalgeographic.com/2011/11/iceman-autopsy/hall-texthttp://ngm.nationalgeographic.com/2011/11/iceman-autopsy/hall-texthttp://www.nature.com/news/iceman-s-dna-reveals-health-risks-andrelations-1.10130http://www.nature.com/news/iceman-s-dna-reveals-health-risks-andrelations-1.10130http://ngm.nationalgeographic.com/2011/11/iceman-autopsy/hall-texthttp://textbookofbacteriology.net/Lyme_2.htmlhttp://www.thelancet.com/journals/laninf/article/PIIS1473-3099%2812%2970054-3/fulltexthttp://www.nytimes.com/2001/06/17/magazine/17LYMEDISEASE.html?pagewanted=all


13/16The Nucleus March 2013 13

Meeting NoticeAmerican Chemical SocietyCentral Massachusetts Section Meeting

Tuesday, March 5, 2013

Fitchburg State UniversityRoom 314, Hammond Bldg Tower, 160 Pearl St, Fitchburg, MA

6:00 pm Arrival, Refreshments

7:00 pm Lecture

J. Gregory Reid, Ph.D., Mastering the 5000-L Rotavap and OtherChallenges to Making Drugs on Industrial Scale

Directionshttp://www.fitchburgstate.edu/about-us/directions/. Parking: North Street Lots 1

and 2 - #5 & 6 on Campus Map.(http://www.fitchburgstate.edu/uploads/files/Directions/ParkingLotMap.pdf).Hammond Building is the adjacent brick and glass building with the glasstower in the center. Room 314 is on 3rd floor. Please RSVP Host/Contact: Dr.Mel Govindan [email protected]; Cell: 978-660-8831.

BiographyJ. Gregory Reid decided he wanted toinvent beautiful processes to makedrugs while he was studying chemistry

at the University of Michigan. Afterearning a PhD with Ed Vedejs at theUniversity of Wisconsin and doing

postdoctoral research with E. J. Coreyat Harvard, he accepted a position as aScientist in Chemical Process R&D atUpjohn. Since then his career hasincluded 13 years at Big Pharma doing

process R&D, 2 year s st ar ti ng andmanaging a successful custom synthe-sis company, 8 years at different Con-tract Research Organizations (CRO) inthe US, 2 years at a CRO in India, and

2 years as a visiting professor at UnionCollege in Schenectady. He is cur-rently a chemistry consultant workingout of his home in Groton, MA.

AbstractAfter spending years figuring out

processes to make grams of complexmolecules in a lab, I began to wonder

how they are made on very large scalein industry. This continued as I startedwork as a process chemist at a majordrug company. One of the challenges -understanding and controlling reac-tions - was still very important, but alot of additional challenges wereadded. Process safety, purifications,raw material constraints (due to bothcost and safety), productivity, reactorlimitations, reuse/recycle of wastestreams, etc. became important consid-erations. Many of these challenges will

be highlighted with entertaining real-life examples of process R&D, includ-ing a comparison with how this workis done in India. Students are particu-larly encouraged to attend.

NESACS

Candidatesfor 2013Chair-Elect

Katherine LeeJames Phillips

Councilor /Alternate Councilor

Michael SingerLee JohnsonMary ShultzBob LichterSophia Su

Ken MattesMary MahaneyRaj RajurAndrew ScholteMarietta SchwartzHeidi TengSonja Strah-PleynetWilton Virgo

Trustee

Chuck KolbDorothy Phillips

Director-at-Large

Gary WeismanJohn NeumeyerDavid HarrisMukund Chorghade

Nominating Committee

Sophia SuHeidi TengMarietta SchwartzRaj Rajur

Esselen Award Committee

Jeffrey SteinfeldEric Jacobsen

Vinod PatelKarl Hansen

Richards Award Committee

Jerry JasinskiHoward MayneMorton HoffmanJames Morken

Petition Candidates: Any group com-prising 2 per cent or more of the North-

eastern Section (136 members) may

nominate candidates See NESACS

website for details.

iceman-s-dna-reveals-health-risks-and-relations-1.10130

9 James OBrien, Boston.com, October 11,2011. http://www.boston.com/news/local/

articles/2011/10/16/deer_hunt_in_med-field_takes_aim_at_lyme_disease/

10 Michael Braverman, Germs Gone Wild:The Horrific Secrets of Plum Islandhttp://www.trutv.com/conspiracy/govern-ment-lies/plum-island/lyme-disease.html

http://www.nature.com/news/iceman-s-dna-reveals-health-risks-andrelations-1.10130http://www.nature.com/news/iceman-s-dna-reveals-health-risks-andrelations-1.10130http://www.boston.com/news/local/articles/2011/10/16/deer_hunt_in_medfield_takes_aim_at_lyme_disease/http://www.boston.com/news/local/articles/2011/10/16/deer_hunt_in_medfield_takes_aim_at_lyme_disease/http://www.boston.com/news/local/articles/2011/10/16/deer_hunt_in_medfield_takes_aim_at_lyme_disease/http://www.boston.com/news/local/articles/2011/10/16/deer_hunt_in_medfield_takes_aim_at_lyme_disease/http://www.boston.com/news/local/articles/2011/10/16/deer_hunt_in_medfield_takes_aim_at_lyme_disease/http://www.nature.com/news/iceman-s-dna-reveals-health-risks-andrelations-1.10130


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B U S I N E S S D I R E C T O R Y

SERVICESSERVICESSERVICES


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CAREER SERVICESSERVICES

B U S I N E S S D I R E C T O R Y

SERVICES

Index of AdvertisersAsisChem, Inc. ....................14

Boston College....................15

ChemDev Solutions ..............7

Eastern Scientific Co.............6

Front Run OrganX, Inc........14

Huffman Laboratories, Inc. .14

Mass-Vac, Inc. .......................2

Micron Inc. ..........................14

New Era Enterprises, Inc.....14NuMega Resonance Labs....14

Organix, Inc.........................14

PCI Synthesis ......................13

PolyOrg, Inc. .......................15

Rilas Technologies, Inc. ......15

Robertson Microlit Labs. ....14

Vaccubrand, Inc.....................4

Waters Corporation .............15


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Check the NESACS home pagefor late Calendar additions:http://www.NESACS.orgNote also the Chemistry Department webpages for travel directions and updates.These include:http://www.bc.edu/schools/cas/chemistry/semina

rs.htmlhttp://www.bu.edu/chemistry/seminars/http://www.brandeis.edu/departments/chemistry/

events/index.htmlhttp://www.chem.harvard.edu/courses/seminars.

phphttp://chemcalendar.mit.edu/index.phphttp://chem.tufts.edu/seminars.htmlhttp://engineering.tufts.edu/chbe/newsEvents/se

minarSeries/index.asphttp://www.chem.umb.eduhttp://www.umassd.edu/cas/chemistry/http://www.uml.edu/Sciences/chemistry/Seminar

s-and-Colloquia.aspxhttp://www.unh.edu/chemistry/events

Mar 04

Prof. Yi Lu (Illinois State Univ.)Rational Design of Metalloproteins asBiocatalysts for Sustainable Energy:ExploringRoles of Non-covalent Interactions in Conferringand fine-tuning Enzymatic ActivitiesBrandeis, Gerstenzang 1214:00 p.m.

Prof. Todd Lowary (Univ. of Alberta)Amphiphilic Mycobacterial Glycans: Synthesis,BiosynthesisandLipid--bindingProperties

Northeastern Univ. 129 Hurtig Hall12:00 noon

Prof. David Speigel (Yale University)Harvard, Pfizer Lecture Hall, TBA,4:15pm

Mar 05Zachary Kean (Duke University)UNH, Room N104 (formerly L103)11:10 am

Prof. Todd Lowary (Univ. of Alberta)Furanoside biosynthesis in mycobacteria andcampylobactersTufts, Pearson Chemistry Building, Room P-1064:30 pm

Mar 06Prof. Clay Bennett (Tufts)

U. Mass. Dartmouth, SENG, Room 1154:00 PM

Mar 11Prof. Jack Taunton (U. C. San Francisco)Harvard, Pfizer Lecture Hall,4:15pm

Prof. David Jenkins (University of Tenn.)Brandeis, Gerstenzang 121 4:00 p.m

Prof. Erin E. Carlson (Indiana Univ.)Chemical Probes to Explore and InhibitBacterial Growth and PathogenesisMIT, 56-1144:00 pm

Mar 12Prof. David Anderson (University of Wyoming)Cold Chemistry in Parahydrogen QuantumSolids: What Arrhenius Didnt Tell YouMIT, 6-1204:30 pm

Prof. Kenichi Kuroda (University of Michigan)Designing antimicrobial polymers as syntheticmimics of host-defense peptidesTufts, Pearson Chemistry Building, Room P-1064:30 pm

Mar 13Prof. David Jenkins (Univ. of Tennessee)MIT, 6-1204:15 pm

Prof. James Chambers (U. Mass.-Amherst)WPI, Gateway Park, Rm. 100212:00 Noon

Mar 18Prof. Seth Herzon (Yale)Target-Driven Total SynthesisBrandeis, Gerstenzang 121 4:00 p.m.

Prof. Kevin Weeks, University of NorthCarolina, Chapel HillMIT, 56-114 4:00 pm

Mar 19Prof. Eli Zysman-Colman (Universit deSherbrooke, Canada)Illuminating Iridium: From Visual Displays to

Solar CellsBoston College, Merkert 1304:00 PM

Prof. Liviu Mirica (Washington Univ.)Harvard, Pfizer Lecture Hall, 4:15pm

Mar 20Prof. Liviu Mirica (Washington Univ.)MIT, 6-1204:15pm

Prof. Chris Douglas (Univ. of Minnesota)Catalysis based on the insertionof transitionmetals adjacent to carbonyls: caboacylation,oxyacylation and hydroacylation of alkenes

Northeastern Univ. 129 Hurtig Hall12:00 noon

Boston College University Lecture Series inChemistryProf. Dennis A. Dougherty (California Instituteof Technology)Chemistry on the Brain: Understanding the

Nicotine ReceptorBoston College, Merkert 1274:00 - 5:00 PM

Mar 20 -21Iddles Lecture Series

Prof. Mark A. Ratner (Northwestern University)3/20 Sustainability and Energy - The Story of

our Time3/21 TBAUNH, Room N104 (formerly L1030)11:10 am

Mar 21Bristol-Myers Squibb Lectures in Organic

Chemistry

Prof. Tobias Ritter, HarvardJeffrey Robl, Bristol-Myers SquibbMIT, 6-1204:00 pm

Boston College University Lecture Series in

Chemistry

Prof. Dennis A. Dougherty (California Instituteof Technology)The Cation- Interaction: A New View ofBenzene, Phe, Tyr, and TrpBoston College, Merkert 127 4:00 pm

Mar 22Boston College University Lecture Series in

Chemistry

Prof. Dennis A. Dougherty (California Instituteof Technology)Chemical-Scale Studies of Neuroreceptors andIon Channels: What Have We Learned?Boston College, Merkert 127 2:30 pm

Mar 25Prof. Andrew Phillips (Yale)Harvard, Pfizer Lecture Hall, 4:15pm

Prof. William M. Clemons (California Instituteof Technology)MIT, 56-114 4:00 pm

Mar 26TISHLER AWARD LECTURE

Prof. Roderick MacKinnon (RockefellerUniversity)The Remarkable Diversity of K+ ChannelsTufts, Pearson Chemistry Building, Room P-1064:30 pm

Prof. Kay Brummond (University of Pittsburgh)UNH, Room N104 (formerly L1030)11:10 am

Mar 27Prof. Jens Norskov (School of Engineering,Stanford Univ.)

Northeastern Univ., 129 Hurtig Hall12:00 noon

Prof. Timothy Warren (Georgetown Univ.)Harvard, Pfizer Lecture Hall 4:15pm

Mar 28Prof. Haekjip Ha (University of Illinois)Harvard, Pfizer Lecture Hall 4:15pm

Notices for The NucleusCalendar of Seminars should besent to:Sheila E Rodman, email:

serodman(at)hotmail com

NONPROFITO

RG.

U.S.POSTAGE

PAID

NORTHEASTERN

SECTION

AMERICANCHE

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19MillRoad

Harvard,MA01451
http://www.bc.edu/schools/cas/chemistry/seminars.htmlhttp://www.bc.edu/schools/cas/chemistry/seminars.htmlhttp://www.brandeis.edu/departments/chemistry/events/index.htmlhttp://www.brandeis.edu/departments/chemistry/events/index.htmlhttp://www.chem.harvard.edu/courses/seminars.phphttp://www.chem.harvard.edu/courses/seminars.phphttp://engineering.tufts.edu/chbe/newsEvents/seminarSeries/index.asphttp://engineering.tufts.edu/chbe/newsEvents/seminarSeries/index.asphttp://www.uml.edu/Sciences/chemistry/Seminars-and-Colloquia.aspxhttp://www.uml.edu/Sciences/chemistry/Seminars-and-Colloquia.aspxmailto:[email protected]:[email protected]://www.uml.edu/Sciences/chemistry/Seminars-and-Colloquia.aspxhttp://engineering.tufts.edu/chbe/newsEvents/seminarSeries/index.asphttp://www.chem.harvard.edu/courses/seminars.phphttp://www.brandeis.edu/departments/chemistry/events/index.htmlhttp://www.bc.edu/schools/cas/chemistry/seminars.html

Documents

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