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667
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
Copyright 0 1973 by The Williams & Wilkins Co.
INDEX
Vol. 187, No. 3Printed in U.S.A.
Volume 187, October-December 1973
Abildskov, J. A., see Urthaler, F., 269
Acetaminophen-iiiduced hepatic necrosis, protective role of
glut.at.hione, 211-induced hepatic necrosis, role of covalent bind-
ing in vivo, 195-induced hepatic necrosis, role of cytochrome
P-450-mediated covalent. binding in vitro, 203-induced hepatic necrosis, role of metabolism,
1852-Acetylaminofluorene, cytochrome P450-depend-
eat binding to microsomes, 203Acetylcholine turnover rate in rat salivary glands,
effect of deafferentation and duet ligation on,measured by steady-state kinetics, 68
Acetylstrophanthidin
effects on spinal cord neural mechanisms, 246inotropic effect, antagonism by aldosterone, 112
Adenosine monophosphate , cyclic , in guinea-pig
heart., increased by phenylephrine, 296Adrenergic blockade, beta, effect on intramyo-
cardial distribution of coronary blood flow,451
Adrenergic neural tone, dependence of sirius node
and atrioventricular junction for automat icityOn, 269
Adrenergic receptoralpha, labeling by ‘4C-Dibenamine, specificity,
524
beta, in isolated rat utertis, relation to mecha-
nism of action of histamine, 511Adrenergic responses, in dog cutaneous vascula-
tore, effects of indomethacin and eicosa-5,8, -11,14-tetraynoic acid (prostaglandin synthesis
inhibitors) on, 315Aldosterone, antagonism of positive inotropic ef-
feet of cardiotonic steroids, 112Alter, W. A., III, Weiss, G. K., Priola, I). V., and
Spurgeon, H. A. : The effects of 6-hydroxy-dopamine on vagal cardioaccelerator systems,99
Amines
biogenic, brain, related to effects of tricyclicantidepressants on attack elicited by hy-
pothalamic stimulation, 550Amines , sympathomimet ic (see Sympat homimetic
amines)Amino acid, hexose and, assimilation by epithe-
hum and muscle of guinea-pig seminal vesicle,
430
Arninoguanidine, effect on metabolism of hista-
mine in brain, 34a-Aminoisobutyric acid, assimilation by epithe-
hum and muscle of guinea-pig seminal vesiele,
430Ammon, H. P. T., Orci, L. and Steinke, J. : Effect
of chlorpromazine (CPZ) on insulin release in
V?t’O and in vitro in the rat, 423
Amodiaquine, effects on metabolism of histamine
in brain, 34
Amphetamine
effects in hypertensive dogs, 308optical isomers, self-administration by rats, 27
d-Amphetaminechlorpromazine , imipramine, morphine and,
self-administration in cocaine-dependent rhe-sus monkeys, 8
morphine and, effects upon locomotor activity ofmice treated with drugs which alter brain
catecholamine content, 1-stimulated behavior in rat, effects of naloxone,
380
d- and i-Amphetamine, effects on fixed-intervaland fixed-ratio behavior in tolerant and non-tolerant rats, 372
Anderson, E. (;., see Taber, C. A., 229
Angiotensin-induced responses in dog gracilismuscle, antagonism by exercise, 78
Antiarrhythmic properties, of UM-272 in canineheart, 260
Anticoagulant action, of dicumarol in rats, effectof phenylbutazone, 176
Antipyrine, metabolism in patients with chronic
renal failure, 612
Antischistosomal drugs
hycanthone effects on spermatogonial cells, de-oxyribonucleic acid synthesis in bone marrow
and dominant lethality in rats, 437
mutagenic act-ion of hycanthone and IA-I on
yeast, 444
Aorta
ral)bit, specificity of alpha adrenergic receptorlabeling by “C-Dibenamine in, 524
rabbit, vascular reaction to vasodilators in, 324
Appel, W. C. and Vincenzi, F. F. : Positive mo-
dopamine , elevation during naloxone-precipi -
668 INDEX Vol. 187
tropic effect of cardiotonic steroids : Differen-tial antagonism by aldosterone, 112
Arachidonic acid, prostaglandins E2 and F� and,
effects on longitudinal stomach strip of rat,501
Archer, R. A., see Lemberger, L., 169
Arias, I. M., see Lichter, M., 612Arthritis, adj uvant-induced, in rat, interactions
of aspirin, indomethacin and other drugs in,
400Aspirin, interactions with indomethacin and other
drugs in adjuvant-induced arthritis in rat., 400Atria, rabbit , aldosterone antagonism of positive
inotropic effect of cardiotonic steroids in, 112
Atrioventricular junction, sinus node and, dog,dependence for ant omaticit.y on adrenergic
neural tone, 269Azathioprine, methylnitroimidazole moiety, met-
abolic fate in rat, 588
Beacham, L. M., III, see de Miranda, P., 588
Behavior
attack, elicited by hypothalamic stimulation,
effects of tricyclic antidepressants related tobrain biogenic amines, 550
cyclazocine-stimulat.ed, in rats, effects of nal-oxone, 380
fixed-interval and fixed-ratio, in tolerant and
nontolerant. rats, effects of d- and l-ampheta-mine, 372
self administration (see Self-administration be-
havior)
Benoist, J. M., see Besson, J. M., 239Benzphet-amine, effects in hypertensive dogs, 308
Berndt, W. 0., see Cooke, W. J. , 158Besson, J. M., Wyon-Maillard, M. C., Benoist,
J. I’sI., Conseiller, C. and Hamann, K. F.:Effects of phenoperidine on lamina V cells inthe cat dorsal horn, 239
Bile, excretion of iopanoate and iophenoxate inrat, effects of phenobarbital and taurocholate,158
Black, M., see Lichter, M., 612Blauw, A. S., II, see Priola, D. V., 121Blood, content in small vessels of canine myocar-
dium, effect of pentrinitrol, nitroglycerin andpropranolol, 465
Blood flowcoronary, beta adrenergic blockade on int.ramyo-
cardial distribution of, 451hepat-ic, d-propranolol clearance and, in mon-
key, increased by glucagon, 581
Boucher, H. , see Langelier, P. , 15Brain
cat, biogenic amines, relation to effects oftricyclic antidepressaiits on attack elicited byhypothalamic stimulation, 550
t ated withdrawal in morphine-dependent mice
and rats, 558mouse, altered catecholamine content, loco-
motor activity and, 1mouse, metabolism of ‘4C-histamine in, 34
type B monoamine oxidase in, �3-pheny1ethyl-amine as specific substrate for, 365
Branch, II. A., Shand, D. 0. and Nies, A. S.:
Hemodynamic drug interactions: The reduc-tion of oxyphenbutazone clearance by dl-propranolol in the dog, 133
Branch, B. A., Shand, I). 0. and Nies, A. S. : In-crease in hepatic blood flow and d-propranololclearance by glucagon in the monkey, 581
Brendel, K. and Meezan, E. : Properties of a puremet abolically act ive glomerular preparation
from rat kidneys. II. Metabolism, 342Brendel, K., see Meezan, E., 332, 352Bretylium tosylate, inotropic action on heart, 121
Briner, W. H., see Somjen, G. C., 602
Bristow, � see (.reen, ii. D., 524
Brodie, B. B.
see J1)llOW, 1.). J. , 195see Mitchell, J. IL, 185, 211
see Potter, W. Z., 203
Brody, M. J., see Powell, J. R., 495
Bromobenzene-induced liver necrosis , role ofdetoxifying enzymes, 218
Brubaker, P. E., see Somjen, C. (1., 602
Bunolol, beta adrenergic blocker, effect. on int.ra-myocardial distribution of coron ary blood
flow, 451
Burcher, E. and Garlick, D. : Antagonism of vaso-constrictor responses by exercise in the gracilis
muscle of the dog, 78Burgess, M. J., see Urthaler, F., 269
Buxbaum, S., set Katchen, B., 152
Cadmium, effects on spermatogenesis studied by
veloci ty sedimentation cell separati on andserial mating, 641
Cafruny, E. J., see Nigrovic, V., 620
Calcium-induced responses of atrial and vascularmuscle, influence of magnesium, 86
Cannabinoid, synthetic (�6a. 10* dimethyl heptyltet rahydrocannabinol) ‘ metabolism , 169
Cannon, W. B., III, see Priola, 1). V., 121
Carbon monoxide, effect on covalent binding in
vitro of acetaminophen in hepatic microsomes,203
Cardiac glycosidesabsorption from rat respiratory tract, 105aglycones and, positive inotropic effect antag-
onized by aldosterone, 112
Cardioaccelerator systems, vagal, effects of 6-hy-droxydopamine, 99
Cardiotonic steroids (cardiac glycosides and
1973 INDEX 669
imiprami tie, morphi ne, d-amphet amine and, self-
aglycones), positive inotropic effect antago-
nized by aldosterone, 112
Cardiovascular effectsof glucagon in cat with chronic heart failure, 475of glyceryl trinitrate and pentrinitrol by dif-
ferent routes of administration in dog, catand rat. , 300
Carlson, E. C., see Meezan, E., 332
Carr, J. V., see Green, S., 437Carrier, 0., Jr., see Turlapat.y, P. D. M. V., 86
Cat(s)blockade by p-chlorophenylalanine of 5-hy-
droxytryptophan facilitatory actions on spinal
reflexes in, 229brain biogenic amines, relation to effects of
tricyclic antidepressant.s on attack elicited byhypothalamic stimulation, 550
Changes in spinal cord neural mechanisms as-
sociat-ed with digitalis in, 246dog, rat and, comparative cardiovascular effects
of glyceryl t.rinitrat.e and pentrinitrol by dif-ferent routes of administration in, 300
dorsal horn, effects of phenoperidine on lamina
V cells in, 239
normal and lesioned, effects of chronically ad-ministered L-dopa, 15
spleen , inhibition by sympathomimet.ic amitiesof nerve stimulat ion -evoked norepinephrinerelease in, 529
��ith chronic heart failure, enhancement of car-
dine performance by glucagon in, 475Cat.echolamine content, altered, in mouse brain,
locomotor activity and, 1
Cellslamina \T, in cat dorsal horn, effects of pheno-
peridine, 239spermat ogonial, deoxyribonucleic acid synthesis
in bone marrow, dominant lethality and, inrats, effects of hycanthone, 437
Chang, IL, see Liii, C-C., 415Cheney, D. L., see Hanin, I., 68
Cheng, M. C. , see Waud, B. E. , 40
Chlorgyline, effects on types A and B monoamineoxidase of brain, 365
Chiorimipramine, effects on attack elicited byhypothalamic stimulation, relation to brain
biogenic amines, 550
p-Chlorophenylalanine, blockade of 5-hydroxy-trypt ophan facilitat ory act ions on spinal re-
flexes by, 2292-(3-Chloro-o-t.oluidino) nicot-inic acid (see Clo-
nixin)
Chlorphentermine, effects on hypertensive dogs,
308Chiorpromazine
effect on insulin release in vivo and in vitro in rat,423
administration in cocaine-dependent rhesusmonkeys, 8
Clarke, D. E. and Sampath, S. S. : Studies on thefunctional role of intraneuronal monoamine
oxidase, 539
Clonixin [2- (3-chloro-o-toluidino) nicotinic acid],metabolism in man, 152
Cobaltous chlorideeffect on acetaminophen-induced hepatic ne-
crosis, 185, 195
effect on covalent binding in vitro of acetami-nophen in hepatic microsomes, 203
Cocaine-dependent rhesus monkeys , chlorpromazine,
imipramine , morphine and d-amphetamineself-administration in, 8
effect on uptake and accumulation of �1I-6,7-dihydroxytetrahydroisoquinoline by periph-
eral sympathetic nerves, 56
Cohen, G., see Locke, S., 56Commarato, M. A., Winbury, M. M. and Kaplan,
H. IL : Glyceryl t.rinitrate and pentrinitrol
(pentaerythritol trinitrate) : Comparativecardiovascular effect-s in dog, cat and rat by
different routes of administration, 300Conseiller, C. , see Besson, J. M., 239Constantine, J. W. and Purcell, I. M. : Inhibition
of platelet aggregation and of experimentalthrombosis by sudoxicam, 653
Cooke, W. J., Berndt, W. 0. and Mudge, G. H.:Effects of phenobarbital and taurocholate on
biliary excretion of iopanoate and iophenoxate
in the rat, 158
Coronary effects of dopamine in dog, 280
Costa, E., see Hanin, I., 68Covalent binding
in vitro, cytochrome P-450 mediated, role inacetaminophen -induced hepatic necrosis , 203
in vivo, role in acetaminophen-induced hepaticnecrosis, 195
Crayfish, giant axons, effect of spart.eine on nervemembrane potassium conductance in, 47
Creagh, T. H., see de Miranda, P., 588
Cucinell, S. A., see Israili, Z. H., 138Cyclazocine-stimulated behavior in rats , effects
of naloxone, 380
Cyst.eine, pretreatment in mice, effect on aceta-minophen -induced hepat.ic necrosis , 211
Cytochrome P-450-mediated covalent binding invitro, role in acetaminophen-induced hepaticnecrosis, 203
Dapsone, metabolism in man and experimental
animals , formation of N -hydroxy metabolites,138
1)avis, D. C.
see Jollow, I). J. , 195
see Mitchell, J. R.., 185
670 INI)EX Vol. 187
amine in rat, 380
effect of phenylbutazone on distribution, elimi-
see Potter, W. Z., 203Davis, E., see Israili, Z. H., 138
Dayton, P. (;., see Israili, Z. H., 138Deafferentation, effect on acetylcholine turnover
rate in rat salivary glands measured by
steady-state kinetics, 68
Dembiec, 1)., see Locke, S., 56de Miranda, P., Beacham, L. M., III, Creagh, T.
H. and Elion, G. B. : The metabolic fate of themethylnitroimidazole moiety of azathioprine
in the rat, 5882-1)eoxyglucose, assimilation by epithelium and
muscle of guinea-pig seminal vesicle, 430Deoxyribonucleic acid, synthesis in bone marrow,
spermatogonial cells, dominant lethality and,in rats, effects of hycanthone, 437
Deprenyl, effects on types A and B monoamine
oxidase of brain, 365Desipramine, effects on attack elicited by hy-
pothalamic stimulation, relation to brain
biogenic amines, 5506-Desmethylgriseofulvin, as major metabolite of
‘4C-griseofulvin in man, 415Desmethylimipramine, effect on uptake and ac-
cumulation of �H-6, 7-dihydroxytetrahydro-isoquinoline by peripheral sympathetic
nerves, 56
‘4C-Dibenamine, specificity of alpha adrenergicreceptor labeling by, 524
Dicumarol, distribution, elimination and antico-agulant action in rats, effects of phenylbuta-
zone, 176Diethyl maleate, pretreatment in mice, effect on
acetaminophen-induced hepatic necrosis , 211
Diformyl dapsone, metabolism in man and experi-mental animals, 138
Digitalis materials, changes in spinal cord neuralmechanisms associated with, 246
Digitoxigenin, effects on spinal cord neuralmechanisms, 246
Digitoxin, absorption from rat respiratory tract,105
Digoxin, absorption from rat respiratory tract, 105
Dihydroouabain, absorption from rat respiratorytract, 105
‘H-6, 7-Dihydroxytetrahydroisoquinoline, uptake
and accumulation by peripheral sympatheticnerves in vivo, 56
�6a, IOa Dimethyl heptyl tetrahydrocannabinol, in
vitro and in vivo metabolism, 169Dissociation constants, drug-receptor, at mam-
malian neuromuscular junction, effect of
halothane, 40Diuretic response to mercury in dogs, effects of
maleic acid and uranyl on, 620
Dixon, H. L., see Lee, I. P. , 641Dog(s)
antihypertensive effects of sympathomimet.icamines in, 308
beta adrenergic blockade on intramyocardial dis-tribution of coronary blood flow in, 451
cat , rat. and, comparative cardiovascular effects
of glyceryl trinitrat.e and pent.rinitrol by dif-ferent routes of administration in, 300
comparative dependence on adrenergic neural
tone by automaticity in sinus node and atrio-ventricular junction of, 269
coronary and myocardial effects of dopamine in,
280cutaneous vasculature, effect of indomethacin
and eicosa-5,8,11,14-tetraynoic acid (pros-taglandin synthesis inhibitors) on adrenergic
responses in, 315
effects of 6-hydroxydopamine on vagal cardioac-celerator systems in, 99
effects of maleic acid and uranyl on mercurial
diuresis in, 620gracilis muscle, antagonism of vasoconstrictor
response by exercise in, 78heart, antiarrhythmic and electrophysiologic
properties of UM-272 in, 260heart., mechanism of inot.ropic action of bretyl-
ium t.osylat.e on, 121
inhibition of platelet aggregation and experi-
mental thrombosis by sudoxicam in, 653metabolism of � IOa dimethyl heptyl tetrahy-
drocannabinol in, 169myocardium, effect of pentrinitrol, nitroglycerin
and propranolol on small vessel blood content
of, 465reduction of oxyphenbutazone clearance by dl-
propranolol in, 133saliva, ouabain-induced i ncrease in potassium
concentration of, 518skeletal muscle and hindpaw, facilitation of re-
flex vasoconst.riction by prostaglandin F2,, in,495
Dombrosky, J. T., see Mawhinney, M. G., 4301)ominant lethality, spermatogonial cells, de-
oxyribonucieic acid synthesis in bone marrowand, in rats, effects of hycanthone, 437
Dong, E., Jr., see Priola, D. V., 121
L-Dopa, chronically administered, effects in nor-
mal and lesioned cats, 15
Dopamine
brain, elevation during naloxone-precipitated
withdrawal in morphine-dependent. mice and
rats, 558
coronary and myocardial effects in dog, 280
formation in cat brain after L-dopa, 15
in rat brain, effects of cyclazocine, 380
Drug interactions
between aspirin, indomethacin and other drugs
in adjuvant-induced arthritis in rat, 400
between naloxone and cyclazocine or (/-amphet-
1973 INDEX 671
nation and anticoagulant action of dicumarol
in rats, 176
reduction of oxyphenhut azone clearance bydi-propranolol in dog, 133
l)ubinsky, B., Karpowicz, K. and Goldberg, M.E. : Effects of tricyclic antidepressants on at-tack elicited by hypothalamic stimulation:
Relation to brain biogenic amities, 550Duct ligation, effect on acetylcholine turnover
rate in rat salivary glands measured by
steady-state kinetics, 68
Electrophysiologic properties, of UM-272 in canine
heart, 260
Elion, 1;. B., see de Miranda, P., 5885,8,l1,14-Eicosatetraynoic acid
influence OH effects of arachidonic acid and
prostaglandins F�2 and F2a on rat stomachstrip, 501
(prosta.glandin synthesis inhibi t or) , effect onadrenergic responses in dog cutaneous vascit-
lature, 315
lnzymes, detoxifying, role in broniobenzene-in -duced liver necrosis, 218
Ephedrine, effects in hypertensive dogs, 308
Epinephrine, effect on protein synthesis in rat
heart, 482lthacrynic acid, effects on oxidative metabolism
in isolated glomeruli, 352lthanol tolerance in goldfish, 391Exercise, antagonism of vasoconst net or responses
in gracilis muscle of dog by , 78
Fenfluraniine, effects in hypertensive (logs, 308Fishman, J. , Hoffwarg, II . and Ilellnian, L. : 1 )is-
posit ion of naloxone-7 , 8-’lI i n normal andnarcotic-dependent men, 575
Furchgott, H. F., see Kirpekar, S. M., 529
Garlick, 1)., see Burcher, l�., 78(liant axons, crayfish and squid, effect of sparteine
on nerve membrane pot assiuni conduct aitce in,47
(;illette, J. 1�l.see Jollow, I). J. , 195
see Mitchell, J. IL, 185, 211see Potter, W. Z., 203
see Zampaglione, N., 218
(lillilan, H. M., see Lanman, H. (1., 105Gland, salivary, rat, effect of deatlerentation and
duct ligation oii acetylcholine turnover rate
in, measured by steady-state kinetics, 68( ilomerular preparation
isolated, effects of ethacrynic aCid on oxidative
metabolism in, 352pure isolated, from rat- kidneys, effects of eth-
acrynic acid on oxidative metal)olism in, 352
Iure metabolically active, from rat kidneys,isolation, 332
pure metal)olically active, from rat kidneys,
metabolism, 342
( ;hicagonenhancement of cardiac performance in eat with
chronic heart failure, 475
-induced increase in hepatic blood flow and
(/-propranolol clearance in monkey , 581Glucose levels in rats, effect of chlorpromazine,
423
( ;hitat hione, protect ive role in acet aminophen-
induced hepatic necrosis, 211(.;ltttethiniide, effect Ofl metabolism of antipyrine
in man, 612
( lyceryl t rinit rate (see also Nitroglycerin)
pent ri nit ml and , cuniparat ive cardiovasculareffects in dog, cat and rat by different routesof administration, 300
( lycosides, cardiac (see Cardiac glycosides)(.lonier, S., see Zimmerman, B. (1., 315( ;oldherg, i�I. F:. , -see l)ubinsky, B. , 550Goldberg, S. IL, see lloffmeister, F., 8Goldfish, tolerance to ethanol in, 391
Goodrich, J. K., see Somjen, (;. (;., 602
Gracilis muscle (see l\luscle, gracilis)Greizerstein, 11. B. and Smith, C. �I. : l)evelop-
ment and loss of tolerance to ethanol in gold-
fish, 391Green, 1!. 1)., Lefever, (. S., i�heys, E. M. and
Bristow, M. : On the specificity of alpha
adrenergic recel)tor labeling by 14C-Dihen-anline, 524
( ree�i, S. , (‘arr, .1. V. , Sauro, F. lvi. aDd Legator,i\I. S. : l;ffects of hycanthone on spermato-
gonial cells, deoxyribonucleic acid synthesis inhone niarro�v 1111(1 dominant lethality in rats,
437
14(�_( ;ris(�Oft1lvitI , al)sorpt ion , Inetal)olisni and cx-(retion in nian, 415
Gross, (. J. and Wininiry, M. M. : Bela adrenergic
blockade on lot ranivocardial (list ribution of
corotiary blood f1oi�� , 451Guinea pig(s)
brain, metabolisni of ‘4(��lijstttiiii�te in, 34
effec t of halot hane on drug-recept or dissociat ion
constants at neuromuscular junction (If, 40
epithelium tind muscle of seminal vesicle, hexose
1111(1 fl�U�() aCid nssiniilat mit l�’ , 430
heart. , phenylephrine-induced increases of car-
dine (�)ntract ilit y , (ycliC adenosine flU)flO-
phosphate and 1)h�sphorylase a in, 296
influence of tuagnesiuni on calciunt-induced re-
spouses of atrial and vascular muscle of, 86
inhibition of platelet aggregat ion by stidoxicani
in, 653
nietal)olisni of dapsotie in, 138
metabolism of �“ . ‘a” dimethvl heptyl tetrahy-
drocannahinol in, 169
(uzman, � see Villarreal, J. I�., 1
672 INDEX Vol. 187
Haavik, C. 0. and Hardman, H. F. : Evaluation ofthe hypothermic action of tetrahydrocanna-
binols in mice and squirrel monkeys, 568Halot-hane , effect on drug-recept or dissociat ion
constants at mammalian neuromuscular junc-tion, 40
Hamann, K. F., see Besson, J. M., 239
Hamrick, M. , see Zampaglione, N., 218Hanin, I., Cheney, 1.). L., Trabucchi, M., Massa-
relli, H., Wang, C. T. and Costa, E. : Applica-
tion of principles of steady-state kinetics tomeasure acet.ylcholine turnover rate in ratsalivary glands : Effect of deafferentation andduct ligation, 68
Hardman, H. F., see Ilaavik, C. 0. , 568Haseman, J. K., see Somjen, U. (.l. 602heart
blood flow, beta adrenergic blockade on intra-
myocardial distribution of, 451canine, effect of pentrinitrol, nitroglycerin and
propranolol on distribution of blood in, 465dog, antiarrhyt.hmic and electrophysiologic
properties of UM-272 in, 260guinea pig, contractility, increased by phenyl-
ephrine, 296inot.ropic action of bret.ylium tosylate on, 121rat, protein synthesis, effect of sympathomi-
metic drugs, 482heart failure, chronic, in cat, enhancement of car-
diac performance by glucagon, 475Hellman, L., see Fishman, J., 575
Hemodialysis, effect on metabolism of antipyrinein man with chronic renal failure, 612
Herman, S. P., see Somjen, (1. (L, 602hlexose, amino acid and, assiniilation by epit.he-
hum and muscle of guinea-pig seminal vesicle,430
Higgins, C. B., see Vatner, S. F., 280
histamine, mechanism of action on isolated ratuterus, 511
“C-Histamine, metabolism in brain, 34
Ho, I. K., see Iwamoto, E. T., 558Hoffmeister, F. and (oldberg, S. B. : A comparison
of chlorpromaz inc , imipramine , morphineand d-amphetamine self-adm mist ration in
cocaine-dependent- rhesus monkeys, 81Ioltzinan, S. G. and Jewett, H. E. : Stimulation of
behavior in the rat by cyclazocine: Effects ofnaloxone, 380
Homovanillic acid, formation in cat brain after
L-dopa, 15Howe, B. B. and Winbury, M. M.: Fffeet of
pentrinit rol , nitroglycerin and propranolol on
small vessel blood content of the canine myo-cardium, 465
Hycanthone
effects on spermatogonial cells, deoxyribonucleicacid synthesis in bone marrow and dominantlethality in rats, 437
IA-4 and, mutagenic action on yeast, 444Hydroxyamphetami tie , effects in hypertensive
dogs, 3086-Hydroxydopamine
effect on uptake and accumulation of ‘H-6,7-dihydroxytetrahydroisoquinoline by periph-
eral sympathetic nerves, 56effects on vagal cardioaccelerator systems, 99
5-Hydroxyt.ryptamine (see also Serotonin)
possible mediation of 5-hydroxytryptophanfacilitatory actions on spinal reflexes, 229
5-Hydroxytryptophan , facilitat.ory actions on
spinal reflexes, blockade by p-chlorophenyl-alanine, 229
Hypertension , in dogs, effects of sympathomimet.ic
amines, 308Ilypothermic action , of tetrahydrocannabinols in
mice and squirrel monkeys, 568
IA-4, hycanthone and, mutagenic action on yeast,
444Imipramine
chlorpromazine, morphine, d-amphet amine and,
self-administration in cocaine-dependent rue-sus monkeys, 8
effects on attack elicited by hypothalamicstimulation, relation to brain biogenic arnines,
550
Indomet-hacin
influence on effects of arachidonic acid andprostaglandins E2 and F2� on rat stomachstrip, 501
interactions with aspirin and other drugs in ad-
juvant-induced arthritis in rat, 400(prostaglandin synthesis inhibit or) , effect on
adrenergic responses in dog cutaneous vas-culature, 315
Inotropic actionof bretylium tosylate on heart., 121of cardiotonic steroids, antagonism by aldos-
terone, 112
pressor and, of dopamine in dog, parasympatho-1%-tic augmentation, 280
Insulin, release in vito and ii, vitro iii rat, effect ofchlorpromazine, 423
lopanoate, iophenoxate and, hiliary excretion in
rat, effects of phenobarbital and taurocholate,
158lophenoxate, iopanoate and, biliary excretion in
rat., effects of phenoharbital and taurocholate,
158Isomers , of amphet aini ne and met hylamphet a-
mine, self-administration by rats, 27Isometheptane, effects in hypertensive dogs, 308
Isoproterenoleffect on protein synthesis in rat heart, 482inhibition of nerve stimulation-evoked nor-
epinephrine release in cat spleen, 529inotropic effect, antagonism by aldosterone, 112
1973 INDEX 673
Langelier, P., Roberge, A. G., Boucher, R. and
Isoxsuprine, effects in hypertensive dogs, 308
Israili, Z. H., Cucinell, S. A., �‘aught, J., I)avis,E., Lesser, J. M. and Dayton, P. G. : Studies
of the metabolism of dapsone in man and cx-perimental animals : Formation of N-hydroxy
metabolites, 138Iwamoto, E. T., Ho, I. K. and Way, E. L. : Eleva-
tion of brain dopamine during naloxone-precipitated withdrawal in morphine-dc-
pendent mice and rats, 558
J#{228}hnchen, E., Wingard, L. B., Jr. and Levy, G.:Effect of phenylbutazone on the distribution,
elimination and anticoagulant action of di-
cumarol in rats, 176Jakschik, B., see Needleman, P., 324
James, T. N., see Urthaler, F., 269
Jewett, II. E., see Holtzman, S. G., 380Johnson, F�. M., Jr., see Needleman, P., 324Jollow, D. J., Mitchell, J. R., Potter, W. Z., Davis,
D. C., Gillette, J. R. and Brodie, B. B.:Acetaminophen-induced hepat.ic necrosis. II.
Role of covalent binding in vivo, 195
Jollow, D. J.
see Mitchell, J. R., 185, 211
see Potter, W. Z., 203see Zampaglione, N., 218
Kaplan, H. B., see Commarato, M. A., 300
Karpowicz, K., see Dubinsky, B., 550Katchen, B., Buxbaum, S. and Ning, J. : Disposi-
tion of clonixin [2-(3-chloro-o-toluidino)nicotinic acid] in humans, 152
Kauker, 1�I. L. : Micropuncture study of renal ac-tion of prostaglandin A2 (PGA2) in rats, 632
Kidneysrat, isolation of pure metabolically active
glomerular preparation from, 332
rat, metabolism of pure metabolically activeglomerular preparation from, 342
rat, pure isolated glomerular preparation, ef-
fects of ethacrynic acid on oxidative metaho-lism in, 352
Kirpekar, S. M., Furchgott, R. F., Wakade, A. R..
and Prat, J. C. : Inhibition by sympat-homi-metic amines of the release of norepinephrine
evoked by nerve stimulation in the cat spleen,529
Kirsch, M., see Nobel-Allen, N., 475Klein, H., see Somjen, G. G., 602Kniffen, F. J., Schuster, D. P. and Lucchesi, B. II.:
Antiarrhythmic and electrophysiologic prop-
erties of UM-272, dimethyl quaternary pro-pranolol, in the canine heart, 260
Koechel, I). A., see Nigrovic, V., 620Kraft, E., see Zimmerman, B. U., 315Krigman, M. R., see Somjen, G. G., 602
Poirier, l.A. J. : Effects of chronically admin-
istered L-dopa in normal and lesioned cats, 15Lanman, B. C., Gillilati, H. Is-i. and Schanker, L.
S. : Absorption of cardiac glycosides from therat respiratory tract., 105
Lee, I. P. and 1)ixoti, H. L. : Fffects of cadmium Ofl
spermatogenesis st tidied by velocity sedi -mentation cell separation and serial mating,
641
Lefever, (!. S., see Green, B. 1.)., 524
Legator, 1�I. S., see Green, S., 437
Lemberger, L., McMahon, IL 1., Archer, H. A.,
Matsumoto, K. and Rowe, II. : The in vitro
and in vivo metabolism of �6a, 1O�t dimet.hylheptyl t.etrahydrocannabinol (I)MPII), 169
Lesser, J. 1�I., see Israili, Z. H., 138
Levy, Cl., see J#{228}hnchen, E., 176
Lichter, M. , Black, M. and Arias, 1. M. : The
metabolism of ant.ipyrine in patients with
chronic renal failure, 612
Lidocaine, effects on ouabain-induced increase in
dog saliva potassium concentration, 518
Liii, C-C., Magat, J., Chang, H., McGlot.ten, J.
and Symchowit.z , S. : Absorption , metabolismand excretion of ‘4C-griseofulviti in man, 415
Liverblood flow , d-propranolol clearance and , i ii inon-
key, increased by glucagon, 581necrosis , acet arninophen -i nduced , l)rOt.ec Live
role of glutathione, 211necrosis, acetaminophen-induced, role of co-
valent binding in i.ivo, 195necrosis, acetaminophen-induced, role of cyto-
chrome P-450-mediat.ed covalent binding in
vitro, 203necrosis , acetaminophen-induced, role of me-
tabolism, 185
necrosis , bromobenzene-induced , role of de-toxifying enzymes, 218
rat. , biot ransforination of methylnit roimidazole
moiety of azathioprine in, 588
Lloyd, J. W., see Mawhinney, M. (�., 430
Locke, S., Cohen, C;. and Dembiec, D. : Uptake and
accumulat ion (-)f �il -6 , 7-dihydrox\’t et rahydro-isoquinoline by peripheral sympathetic nervesin vivo, 56
Locomotor activity of mice treated with drugs
which alter brain catecholaniine (-ontent, ef-
fects of (i-amphetamine and morphine, 1
Lucchesi, B. R.see Kniffen, F. J. , 260see Nobel-Allen, N., 475
Lupanine, effect on nerve membrane potassiumconductance, 47
Magat-, J., see Liii, C.-C., 415
1’Iagnesium, influence on calcium-induced re-
sponses of atrial and vascular muscle, 86
674 INDEX Vol. 187
Maleic acid, uranyl and, effects on mercurial di-
uresis in dogs, 620Mallov, S. : Effect. of sympathomimetic drugs on
protein synthesis in rat heart, 482
Man
absorption, metabolism and excretion of 14C
griseofulvin in, 415
inhibition of platelet aggregation by sudoxicam
in, 653metabolism of clonixin in, 152
metabolism of dapsone in, 138
normal and narcotic-dependent , disposition of
naloxone-7,8-3H in, 575vith chronic renal failure, metabolism of anti-
pyrine in, 612Massarelli, IL, see Hanin, I., 68
Matsumoto, K., see Lemberger, L., 169Mawhinney, I�I. G., I)ombrosky, J. T., Smith, C.
(.1., Thomas, J. A. and Lloyd, J. W. : Hexose
and amino acid assimilation by the epitheliumand muscle of the guinea-pig seminal vesicle,
430
Mc(.Uot.ten, J., see Liii, C-C. , 415
McMahon, fl. E., see Lemberger, L., 169McNeil!, J. and Verma, S. C. : Phenylephrine-in-
duced increases in cardiac contractility, cyclic
adenosine monophosphate and phosphorylasea, 296
Meadows, 1k-I. (;. , Quah, 5.-K. and von Borstel,
II. C. : Mut.agenic action of hycanthone andIA-4 on yeast, 444
l�Ieezan, E. and Brendel, K. : Effects of ethacrynic
acid on oxidative metabolism in isolated
glomeruli, 352
Meezan, E. , Brendel, K. , Ulreich, J. and Carlson,
E. C. : Properties of a pure metabolically ac-tive glomerular preparation from rat kidneys.
I. Isolation, 332Meezan, E., see Brendel, K., 342Mephentermine, effects in hypertensive dogs, 308
Mercury, diuretic response in dogs, effects ofmaleic acid and uranyl, 620
Metabolism
absorption, excretion and, of 14C-griseofulvin inman, 415
in- vitro and in vivo, of � lOa dimethyl heptyltetrahydrocannabinol , 169
of antipyrine in patients with chronic renal fail-
tire, 612
of clonixin in man, 152of dapsone in man and experiment-al animals,
formation of N-hydroxy metabolites, 138
of ‘4C-histamine in brain, 34of methylnitroimidazole moiety of azathiopri ne
in rat, 588
of naloxone-7,8-�H in normal and narcotic-dependent men, 575
of pure metabolically active glomerular prepara-
tion from rat kidneys, 352
oxidative, in isolated glomeruli, effects of etha-crynic acid, 352
role i n acetaminophen -induced hepat ic necrosis,
185role in bromobenzene-induced liver necrosis, 218
Methamphetamine, effects in hypertensive dogs,
308Metaraminol, effects in hypertensive dogs, 308
Methoxamine
effects in hypertensive dogs, 308inhibition of nerve stimulation-evoked nor-
epinephrine release in cat spleen, 529i\-Iet.hylamphetamine, optical isomers, self-ad-
ministration by rats, 273-i\Iethylcholanthrene
effect on acetaminophen-induced hepat ic necro-sis, 185
effect. Ofl bromobenzene-induced liver necrosis,218
3-O-Methylglticose, assimilation by epithelium
and muscle of guinea-pig seminal vesicle, 430Methylhistamine, effect. on metabolism of hista-
mine in brain, 34Methyl mercury (2o3Hg), uptake in tissues related
to neurotoxic effects, 602
Methylphenidate, effects in hypertensive dogs, 308
Micebrain, metabolism of ‘4C-histamine in, 34
effects of cadmium on spermatogenesis in,studied by velocity sedimentation cell separa-
tion and serial mating, 641heart, uptake and accumulation of �H-6,7-di-
hydroxytetrahydroisoquinoline by, 56
hepatic microsomes, binding of acetaminophen
mediated by cytochrome P-450 in, 203
metabolism of M� lOa dimethyl heptyl tetrahy-drocannabinol in, 169
protective role of glutathione in acetaminophen-induced hepatic necrosis in, 211
role of covalent binding in vivo in acetamino-
phen-induced hepatic necrosis in, 195role of drug metabolism in acetaminophen-in-
duced hepatic necrosis in, 185rats and, morphine-dependent, elevation of
brain dopamine during naloxone-precipitatedwithdrawal in, 558
squirrel monkeys and, hypothermic action oftetrahydrocannabinols in, 568
treated with drugs which alter brain cat.echola-
mine content. , effects of d-amphetamine andmorphine on locomotor activity in, 1
Micropunct.ure study of renal action of prost.a-
glandin A2 in rats, 632Microsomes , hepat ic , binding of acetaminophen
to, mediated by cyt.ochrome P-450, 203Millar, K., see Urthaler, F., 269Millard, R. W., see Vatner, S. F., 280Mitchell, J. II. , Jollow, I). J., Potter, W. Z., l)avis,
11). C., Gillette, J. H. and Brodie, B. B.:
chlorpromazine,
(/-amphet amine
1973 INl)EX 675
Acetaminophen-induced hepat ic necrosis. I.
Role of drug metabolism, 185
Mitchell, J. It, Jollow, 1). J., Potter, W. Z., Gil-lette, J. R. and Brodie, B. B. : Acetaminophen-
induced hepatic necrosis. IV. Protective role
of glutathione, 211Mitchell, J. R.
see Jollow, D. J., 195
see Potter, W. Z., 203see Zampaglione, N., 218
Monkey(s)rhesus, cocaine-dependent.,
imipramine, morphine and
self-administration in, 8rhesus, increase in hepatic blood flow and d-
propranolol clearance by glitcagon in, 581rhesus, metabolism of clonixin in, comparison
with man, 152squirrel, mice and, hypothermic action of tetra-
hydrocannabinols in, 568Monoamine oxidase
intraneuronal , funet ional role , 539type B, in brain, $-phenylet.hylamine as specific
substrate for, 365
Morphine
d-amphetamine and, effects upon locomotor ac-tivity of mice treated with drugs which alterbrain catecholamine content, 1
chlorpromazine , imipramine , d-aniphet amine
and, self-administration in cocaine-dependent
rhesus monkeys, 8-dependent mice and rats, elevation of brain
dopamine during naloxone-precipitated with-drawal in, 558
Mudge, C. H., see Cooke, W. J., 158
Muscleatrial and vascular, influence of magnesium on
calcium-induced responses of, 86
gracilis, dog, antagonism of vasoconstrictor re-
sponses by exercise in, 78skeletal, dog, facilitation of reflex vasoconstric-
tion by prostaglandin Fia hi, 495smooth , vascular, sulfhydryl requi rement for
relaxation of, 324
Mutagenic action of hycanthone and IA-4 on
yeast, 444
Myocardial effects of dopamine in dog, 280
Nalorphine, reversal of phenoperidine effects onlamina V cells in cat dorsal horn, 239
Naloxoneeffects on cyclazocine-stimulated behavior in
rats, 380-precipit ated withdrawal in morphine-depend-
ent mice and rats, elevation of brain dopamine
during, 558Naloxone-7,8-H, disposition in normal and riar-
cotic-dependent men, 575Narahashi, T., see Ohta, M., 47
Narcotic-dependent men , disposit ion of naloxone-
7,8-�H in, 575
Needleman, P., Jakschik, B. and Johnson, E. M.,
Jr. : Sulfhydryl requirement for relaxation of
vascular smooth muscle, 324
Neff, N. H., see Yang, Il.-Y. T., 365Nerve, sympathetic, peripheral, uptake and tic-
cumulation of �H -6 , 7-dihydroxyt.etrahydroiso-
quinoline by, 56
Nerve stimulat ion -evoked norepinephrine release
in cat spleen inhibited by sympathomimetic
amines, 529
Nervous system, rat, uptake of methyl mercury
(203Hg) by, relation to neurotoxic effects, 602
Neuromuscular junction, mammalian, effect ofhalothane OH drug-recept or dissociat ion eon -
stants at, 40
Neurotoxic effects, of methyl mercury (203Hg) re-
lated to uptake in various tissues, 602
Nialamide, used in studies on role of monoamine
oxidase in rat., 539
Nicotine-induced vasoconst riction in dog muscle,
facilitation by prostaglandin Fe,,, 495
Nies, A. S.
see Branch, H. A., 133, 581see Splawinski, J. A. , 501
Nigrovic, V., Koechel, 1). A. and Cafruny, E. J.:The effects of maleic acid and uranyl on mer-
curial diuresis in dogs, 620
Ning, J., see Katchen, B., 152
Nitroglycerin (see also ( ;l�’cer)’l trinitrate)
pentrinitrol, propranolol and, effect on small
vessel blood COII ten t of can i tie myocardium,465
Nobel-Allen, N. , Kirsch, M. and Lucchesi, B. H.:
(Uucagon : Its enhancement of cardiac per-
formance in the cat with chronic heart failure,475
Norepinephrine
brain , levels during naloxone-precipit ated with-drawal in morphine-dependent mice and rats,558
effect on protein synthesis in rat heart, 482
-induced responses in dog gracilis muscle, an-tagonism by exercise, 78
in rat brain, effects of cyclazocine, 380release evoked by nerve stimulation in cat
spleen , inhibi t ion l�’ sympat homimet ic
amines, 529responses of dog paw to, effects of indomethacin
and eicosa-5,8,ll,14-tetraynoic acid (prosta-glandin synthesis inhibitors) , 315
synthesis and levels in rats, role of monoamine
oxidase in, 539
NUSS, (... W., see Van Arman, C. G., 400
Oates, J. A., see Splawinski, J. A., 501
Ohta, M. amid Narahashi, T. : Sparteine interaction
676 INI)EX Vol. 187
Wi th nerve membrane potassium conductance,
47Orci, L., see Ammon, H. P. T., 423
Osterberg, R. E. and Raines, A. : Changes in spinalcord neural mechanisms associated with
digitalis administration, 246
Ouabain
absorption from rat respiratory tract, 105
effects on spinal cord neural mechanisms, 246-induced increase in potassiumn concentration in
dog saliva, 518inotropic effect, antagonism by aldosterone, 112
N-Oxidation metabolites, of dapsone in man and
experimental animals, 138Oxyphenbutazone, clearance in dog, reduction by
(/l-propranolol, 133
Pancreatic islets, rat, effects of chlorpromnazine
423
Pancuroniuni , dissociation (oust ant at niani-malian neuron�uscular j ittict ion , effect ofhalothane, 40
Pardo, E. (., see Vidrio, II., 308
Pentaerythritol trinitrate (see Pentrinitrol)Pent,rinit.rol
glyceryl trinitrate and, comparative eardiovas-cular effects in dog, cat and rat by different
routes of administ rati on , 30()nitroglyceri Ii , propranolol and , effect. on small
vessel blood content of canine myocardium,465
Phenmetrazine, effects in hypertensive (logs, 308Phenobarbital
effect on acetaminol)hen-induced hepatic ne-crosis, 185, 195
effect on bromobenzene-induced liver necrosis,218
taurocholate afl(l, effects on biliary excretion ofiopanoate and iophenoxate in rat, 158
Phenoperidine, effects on lamina V cells in catdorsal horn, 239
Phentermine, effects in hypertensive dogs, 308
Phentolamine, inhibition of nerve stimulation-
evoked norepinephrine release in cat spleen,529
Phenylbutazone, effect on distribution, elimina-
tion and anticoagulant action of dictimarol inrats, 176
$-Phenylethylamine, as specific substrate for typeB monoamine oxidase of brain, 365
Phenylephrine
effect in hypertensive dogs, 308
effect on protein synthesis in rat heart, 482-induced increases imi cardiac contractility, cy-
die adenosine monophosphate and phospho-
rylase a, 296inhibition of nerve stimulation-evoked nor-
epinephrine release in cat spleen, 529
Phosphorylase a, in guinea-pig heart, increased by
phenylephrine, 296Pickens, B., see Yokel, II. A., 27
Piperonyl but-oxide, effect on acetaminophen -i n -duced hepatic necrosis, 185, 195
Plasma decay of iopanoate amid iophenoxate in rat,effects of phenobarbital and taurocholate, 158
Platelet aggregat i on , experimental thrombosisand, inhibition by sudoxicam, 653
Poirier, L. J. , see Langelier, P., 15
Potassiumconcentration in dog saliva, increased by oua-
ham, 518conductance, in nerve membrane, effect of
sparteine, 47Potter, W. Z., 1)avis, D. C., Mitchell, J. II., Jol-
low, D. J., (lillette, J. H. and Brodie, B. B.:Acetaminophen-induced hepatic necrosis. III.
Cytochrome P-450-mediated covalent binding
in vitro, 203Potter, W. Z.
see Jollow, 1). J., 195see Mitchell, J. II., 185, 211
Powell, J. H. and Brody, M. J. : Peripheral facilita-
tion of reflex vas(.)constriction � prostaglan-
din F2�,, 495
Practolol, beta adrenergic blocker, effect on in-
tramvocardial dist ribut ion (.)f coronary blood
flow, 451Prat, J. C. , see Kirpekar, S. M. , 529Priola, 1). V., Spurgeon, H. A., Blauw, A. S., II,
Cannon, W. B. , III and l)ong, E. , Jr. : Mecha-nism of the inotropic action of bretyliumtosvlate on the heart, 121
Priola, 1). V., see Alter, W. A., III, 99Procainamide, effects on ouabain-induced increase
in dog saliva potassium concentration, 518
Propylhexedrine , effects in hypertensive dogs,
308Propranolol
be/a adrenergic blocker, effect on intramyocar-dial distribution of coronary blood flow, 451
effects (iii ouabain-induced increase in dogsaliva potassium concentration, 518
pentrinitrol, nitroglycerin and, effect on small
vessel blood content of canine myocardium,465
quaternary derivative (UM-272), antiarrhyth-
mic and electrophysiologic properties incanine heart-, 260
d-Propranolol, clearance, hepatic blood flow and,
in monkey, increased by glucagon, 581dl-Propranolol , reduction of oxyphenbutazone
clearance in dog by, 133
Prostaglandin(s)
A2, renal action in rats, micropuneture study, 632E2 and F�, arachidonic acid and, effects on
longitudinal stomach strip of rat, 501
1973 INl)EX 677
F2a, facilitation of reflex vasoconstriction by,
495
synthesis inhibitors (indomethacin and eicosa-
5,8,11,14-tetraynoic acid), effect on adrener-
gic responses in dog cutaneous vasculature,315
Protein synthesis in rat heart, effect of sympat.h-ornimetic drugs, 482
Pseudoephedrine, effects in hypertensive dogs, 308Purcell, I. 1�I., see Constantine, J. W., 653
Quah, 5.-K., see Meadows, M. (L, 444Q uinidine, effects on ouabain-induced increase in
dog saliva potassium concentration, 518
Rabbit(s)aortic strips, vascular reaction to vasodilators
in, 324
atria, aldosterone antagonism of positiveinotropic effect of cardiotonic steroids in, 112
influence of magnesium on calcium-induced re-
sponses of atrial and vascular muscle of, 86
inhibition of platelet aggregation by sudoxicam
in, 653
metabolism of �6a,iOa dimethyl heptyl tetra-
hydrocannabinol in, 169
specificity of alpha adrenergic receptor labelingby ‘4C-l)ibenamine in , 524
Raines, A., see Osterberg, R. E., 246
Bat(s)
brain, type B monoamine oxidase in, �3-phenyl-
ethylamine as specific stLbstrate for, 365
dog, cat and, comparative cardiovascular effects
of glyceryl trinitrate amid pentrinitrol by dif-ferent routes of administration in, 300
effect of chlorpromazine on insulin release in
vivo and in vitro in, 423effect of naloxone on cyclazocine-stimulated be-
havior in, 380
effect of phenobarbital and taurocholate on bili-ary excretion of iopanoate and iophenoxat-e
in, 158
effect of hycant.hone on spermatogonial cells,deoxyribonucleic acid synthesis in bone mar-row and dominant lethality in, 437
effect of phenylbut.azone on distribution, elimi-nation and anticoagulant action of dicumarol
in, 176functional role of intraneuronal monoamine
oxidase in, 539heart, protein synthesis, effect of sympatho-
mimetic drugs, 482hepatic microsomes , binding of acet aminophen
mediated by cytochrome P-450 in, 203influence of magnesium on calcium-induced
responses of atrial amid vascular muscle of, 86interactions of aspirin, indomethacin amid other
drugs in adjuvant-induced arthritis in, 400
kidneys, isolation of pure metabolically active
glomerular preparation from, 332kidneys, metabolism of pure metabolically ac-
tive glomerular preparation from, 342kidneys, pure isolated glomerular preparation,
effects of ethacrynic acid on oxidative met aim-
lism in, 352
longitudinal stomach strip, effects of arachi-
donic acid amid prostaglandins E2 and F2,, on,
501metabolic fate of methylnitroimidazole moiety
of azathioprine in, 588metabolism of dapsone in, 138
metabolism of �“ ‘#{176}‘ dimet.hyl heptyl tetra-
hydrocannabinol in, 169
mice and , morphine-dependent , elevat ion ofbrain dopamine during naloxone-precipitated
withdrawal in, 558
renal action of prostaglandin A2 in, micropune-ture study, 632
respiratory tract., absorption of cardiac glyco-
sides from, 105
role of detoxifying emizymes in bromohenzene-induced liver necrosis in, 218
role of drug metabolism in acetaminophen-in-duced hepatic necrosis in, 185
salivary glands, effect of deafferentation andduct ligation on acetyleholine turnover ratein, measured by steady-state kinetics, 69
self-administration of optical isomers of am-phetamine amid methylamphetamine by, 27
tolerant and nontolerant, effects of d- and 1-
amphet amine on fixed-interval and fixed -ratiobehavior in, 372
uptake amid accumulation of �H-6 , 7-dihydroxy-tetrahydroisoquinolimie in, 56
uptake of methyl mercury (203Hg) imi tissues re-
lated to neurotoxic effects in, 602uterus, mechanism of action of histamine on, 511
Reilly, M. A., see Schayer, II. W., 34Renal effects, of prostaglandimm A2 in rats, micro-
puncture study, 632Bemial failure, chronic, in man, metabolism of
antipyrine, 612Reserpine pret reat ment , effect on 5-hydr xyt ryp-
tophan facilit at ory act iomts on spinal reflexes,229
Respiratory tract, rat., absorption of cardiac
glycosides from, 105Risley, E. A., see Vami Armami, C. (.�., 400Boberge, A. (1., see Langelier, P., 15
Boffwarg, H., see Fishman, J., 575Rowe, H. , see Lemberger, L., 169Ryan, M. J., see Zimmerman, B. Ce., 315
Saliva, dog, ouabain-imiduced increase imi potas-siumu comicentratiomi of, 518
Salivary glamid (see Glamid, salivary)
678 INI)EX TToi. 187
Sampath, S. S. , see Clarke, I). E. , 539
Sauro, F. M. , see Greemi, S. , 437Schanker, L. S., -see Lanmami, H. C., 105Schayer, II. W. amid Reilly, M. A. : Metabolismn of
‘IC-histamine in braimi, 34
Schuster, 1). P., see Kniffen, F. J. . 260Self-administratiomi behavior
in cocaine-depemident rhesus monkeys, 8
of optical isomers of amphetamine and methyl-amphetamnimte by rats, 27
Semimial vesicle, epithelium and muscle, guineapig, hexose and amino acid assimilation by,430
Serial mat ing, velocity sedimentation cell separa-tion and, used to study effects of cadmium on
spermat.ogenesis, 641
Serot oni n (see also 5-Hydroxyt rypt amimie)as specific substrate for type A monoamimie oxi-
dase of brain, 365brain, levels dun ng naloxone-precipi t ated with-
drawal in morphine-dependemit mice amid rats,558
in rat brain, effects of cyclazocine, 380
Shamid, I). (.L, see Bramich, H. A., 133, 581Sheys, E. M., see Green, H. 1)., 524
Siegel, I. A. : Increases in potassium concemitratiomiof dog submaxillary saliva during intravenousinfusions of ouabaimi, 518
Sinus nodeatrioventricular j unction amid, dog, depemidence
for automaticity on adremiergic neural tomie,
269
Skeletal muscle (see Muscle, skeletal)SKF 525A, effect on bromobenzene-induced liver
necrosis, 218Smith, C. B. , see Villarreal, J. E., 1
Smith, C. G., see Mawhinney, M. G., 430
Smith, C. M., see Greizerstein, H. B., 391Smooth muscle (see Muscle, smooth)Sodium conductance, in nerve membrane, effect of
sparteine, 47
Somjen, G. G., Herman, S. P., Klein, B., Bru-baker, P. E., Brimier, W. 11., Goodrich, J. K.,
Krigman, M. H. amid Haseman, J. K. : The up-
take of methyl mercury (203Hg) in differenttissues related to its neurotoxic effects, 602
Sparber, S. B. , see Tilson, II. A., 372
Sparteine, effect. on nerve membramie potassiumconductance, 47
Spermatogenesis, effects of cadmium omi, studied
by velocity sedimemitatiomi cell separatiomi amidserial mating, 641
Spinal cordcat, dorsal horn lamimia V cells, effect of pheno-
peridine, 239neural mechanisms, chamiges associated with
digitalis, 246Spine, reflexes, facilitatory actions of 5-by-
droxytryptophan omi, blockade by p-chloro-
phenylalanine, 229Splawinski, J. A. , Nies, A. S. , Sweetman, B. and
Oates, J. A. : The effects of arachidonic acid,
prostaglandin L2 and prostaglandin F2a on
the longitudinal stomach strip of the rat, 501Spleemi , cat , inhibition by sympathomimetic
amines of nerve st imulat iou-evoked miorepi-
nephrine release in, 529
Spurgeomi, H. A.see Alter, W. A., III, 99see Priola, I). V. , 121
Squid, giant axons, effect of sparteine on nerve
membrane potassium conductance imi, 47
steady-state kinetics, use to measure effect. of
deafferemitation and duct ligation on acet.yl-choline turnover rate in rat salivary glamids, 68
Steinke, J. , see Ammomi, H. P. T. , 423
Stomachstrips, rabbit, specificity of alpha adrenergic re-
ceptor labelimig by ‘4C-1)ibenamine in, 524strips, rat, effects of arachidonic acid amid pros-
taglandins E2 and Fia (iti, 501Stripp, B., see Zampagliomie, N. , 218Strophanthidin , inotropic effect , ant agomiism by
aldosterone, 112
Strophanthin, imiotropic effect, antagonism by
aldosterone, 112Sudoxicam, inhibition of platelet aggregation and
experimnental thrombosis by, 653Sulfhydryl requirement. for relaxation of vascular
smooth muscle, 324
Sweetman, B., see Splawimiski, J. A., 501
Symchowitz, S., see Liii, C-C., 415
Sympathetic nerve (see Nerve, sympathetic)
Synipathomimetic amines
antihypertensive effects, 3(i8
effect. on protein symithesis in rat heart, 482
inhibition of norepimiephrimie release evoked by
mierve stimulation imi cat spleen, 529
Taber, C. A. amid Amiderson, E. (�. : Paradoxical
blockade by p-chlorophenylalanimie of 5-
liydroxyt rypt ophan facili t atory actions on
spinal reflexes, 229Taurocholate, phenoharbital amid, effects on bili-
ary excretion of iopanoate amid iophenoxate in
rat, 158Tet raliydrocannabinols , hypot hermic act iomi in
mice and squirrel monkeys, 568Tetrahydrozoline, effects in hypertensive dogs, 308Thomas, J. A. , see Mawhinney, M. G., 430Thrombosis , experiment al , platelet aggregat ion
and, imihibition by sudoxicam, 653Tilsomi, H. A. and Sparber, S. B. : The effects of d-
amid l-amphetamimie on fixed-interval amidfixed-ratio behavior in tolerant and nomi-tolerant rats, 372
1973 INI)EX 679
Tolerance to ethanol imi goldfish, 391Tozzi, S. : The mechanism of actiomi of histamine
on the isolated rat uterus, 511
Trabucchi, M., see Hanin, I., 68
Tricyclic antidepressants, effects on attack
elicited by hypothalamic stimulation relatedto brain biogenic amines, 550
Tubocurarine, dissociation constant at mam-
malian neuromuscular j unct ion , effect ofhalothamme, 40
Turlapaty, P. 1). M. \‘. amid Carrier, 0. , Jr. : Itt-
fluence of magmiesi uni omi calcium-induced
respomises of atrial and vascular muscle, 86
Tyramimie, effects on rat uterus, comparisomi with
histamine, 511
Ulreich, J., see Meezami, E., 332UM-272 (dimethyl quaternary propranolol), anti-
arrhyt hmic amid elect rophysiologic propertiesin camiine heart, 260
Uramiyl, maleic acid amid, effects on mercurial
diuresis imi dogs, 620
Urthaler, F., Millar, K., Burgess, M. J., Abilds-kov, J. A. amid James, T. N. : Comparative de-
pendence on adrenergic neural tone by auto-mnaticitv in the sinus miode and in the atrio-
ventricular junctiomi, 269
Uterus, rat, mechanism of actiomi of histamine omi,511
Vami Arman, C. (l., Nuss, (. W. ami(l Hisley, E. A.:Interactiomis of aspirin , i ndoniethacin andother drugs imi adjuvamit-imiduced arthritis imi
the rat, 400Vasoconstrictor responses
amitagonism by exercise in gracilis muscle of dog,
78reflex, facilitatiomi by prostaglamidimi F.�, 495
Vasodilators, possible reaction with sulfhydryl
groups in vascular smnooth muscle, 324
\rasopressin �i nduced respomises i mi dog gracilis
muscle, amitagonisni by exercise, 78Vatmier, S. F., Millard, H. W. and Higgins, C. B.:
Coronary amid myocardial effects of dopamimie
imi the conscious dog: Parasympatholyticaugniemi t at ion of pressor avid imiot ropic actions,280
Vaught, J., see Israili, Z. II., 138
Velocit y sedinient at ion cell separat ion , serial
matimig and, used to study effects of cadmium
on spermatogenesis, 641
Verma, S. C. , see MeNeill, J. , 296Vidrio, H. and Pardo, E. (. : Antihypertemisive
effects of sympathomimetic amines, 308Villarreal, J. E., Guzman, I%L. and Smith, C. B.:
A comparison of the effects of d-amphetamine
amid morphine upon the locomotor activity ofmuice treated with drugs which alter brain
catecliolanune comitemit , 1Vincenzi, F. F., see Appel, W. C., 112von Borstel, H. C., see Meadows, M. (.!., 444
Wakade, A. IL, see Kirpekar, S. M., 529
Wang, C. T., -see Hamiimi, I., 68Wand, B. l. , Cheng, �I. C. and Wand, D. B.:
Comparison of drug-receptor dissociationconstants at the mammalian neuromuscularjunctiomi in the presence and absemice of halo-thane, 40
Wand, 1). IL, see Wand, B. H., 40
Way, E. L., see Iwamoto, E. T., 558
Weiss, (;. K., see Alter, W. A., III, 99Winhury, M. M.
see Commarato, M. A., 300
see Gross, (.l. J., 451see Howe, B. B., 465
Wingard, 14. B., Jr., see J#{228}hnchen, E., 176
Wyon-Maillard, M. C., -see Bessomi, J. M., 239
Yamig, H.-Y. T. and Neff, N. H. : $-Phemiylet.hyl-amine: A specific substrate for type B mono-amine oxidase of braimi, 365
Yeast, mutagenic act-ion of hycamithomie amid IA-4
on, 444\okel, H. A. and Pickemis, B. : Self-administration
of optical isomers of amphetamimie amid
met hylamphetamimie by rats, 27
Zampagliomie, N., Jollow, 1). J., Mitchell, J. B.,Mtripp, B., Hamrick, M. and Gillette, J. B.:
Hole of detoxifying enzymes in bromobenzene-
imiduced liver necrosis, 218Zimniermami, B. (i., Ryan, M. J., Gomer, S. and
Kraft, E. : Effect of the prostaglandin synthe-
sis imihihitors imidoniethacin amid eicosa-5, 8,1 1 , 14-tet rayiioie iteid on adreiiergic responsesin dog eutamieous vasculature, 315
Zinc , imiteract 0)1) with (adtniumii in spermnatogenic
cells,641
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