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Site Minakem de Beuvry Centre de R&D

Introduction to Minafin Group Winners of the 2013 Minafin Chemical Awards

C. Burkett L. Petit

Minafin : a Fine Chem Group • Global fine chemical manufacturer:

– Custom manufacturing – Building blocks – Process development – Scaffold development – Active ingredients

• 5 R&D sites

• 5 industrial sites

– 2 in France and 1 in Germany, all FDA inspected – 2 in the USA

• 6 brands: Minakem Custom Recurring & Generics for commercial drugs, Minakem Custom Development for drugs under clinical testing, Minasolve for cosmetic ingredients, Pennakem for green chemistry, Minathiol for the thio-chemistry and Pressure Chemical for high pressure chemistry

• 2012 net sales: M€ 109, 618 employees at December 31st, 2012

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Focus on the life science industries

Minafin has successfully developed a strong pharma business and diversification niches since the days it was dedicated to the chemistry for APIs under clinical testing

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Sales breakdown per customer category:

Focus on customer specificities & technologies

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• The “End-Market” targets are:

– Cosmetic ingredients (Minasolve) – Commercial pharmaceuticals (Minakem Custom Recurring &

Generics) – Pharmaceuticals under clinical development (Minakem Custom

Development)

• The “Niche technologies” targets are:

– Sulfur chemistry (Minathiol) – Green/Sustainable chemistry (Pennakem) – High pressure and tailor-made polymer chemistry (Pressure Chemical)

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• Minafin’s business units are organized under two separate divisions:

- "End-Markets " dedicated to peculiar segment of customers,

regardless of the needed chemistry

- "Niche Technologies " dedicated to specific know-how and chemical

trees, regardless of the end-market customer

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• Each business unit is managed by a leader assisted by a dedicated team for sales, marketing and R&D

• The management must ensure optimal use of the factories under its jurisdiction

• For the Pharma chemistry, the organization recognizes the specific needs of the commercial APIs versus of those under clinical development

• Minasolve uses either the Group factories or third party manufacturers in its customers’ best interests

Our BUs organization

Lille: our development flagship

• Site (FDA-approved) for small-scale or niche API’s, clinical requirements, long total synthesis

• 150 employees, 150 m3 reaction volume • Organic synthesis 4-16 steps, up to 20 tons • Chemical expertise:

– Cyanidation – Lithiation – Boronic acids – Bromination – Hydrogenation – Carbonylation – C-C coupling

• R&D center • Managed by Minakem

Custom Development

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Leipzig (Leuna): our exothermic specialist

• Leuna (FDA-approved) for medium-scale API’s, high-volume starting materials, hazardous reactions

• 85 employees, 100 m3 reaction volume + continuous reactors • Organic synthesis 3-6 steps, up to 100-200 tons for intermediates • Chemical expertise:

– Hydrazine chemistry

– Acetylene chemistry

– Nitration

– DMS methylation

– Protecting chemistry

– DiBoc in solution

• 2 R&D Centers: – Special reagents for

Minakem Custom Recurring & Generics

– New ingredients & formulation for Minasolve

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Dunkirk: our commercial API factory

• Dunkirk (FDA-approved) for large-scale API’s and repeat productions • 170 employees, 150 m3 reaction volume • Organic synthesis 2-4 steps, up to 300 tons for repeat commercial APIs • Chemical expertise:

– Stereoselective syntheses

– Steroid-compliant unit

– Micronization trains

– Injectable grades

• Managed by Minakem

Custom Recurring & Generics

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Memphis: our green arm • Site (non-cGMP) dedicated to very large-scale, low-cost green chemicals for

all applications • 125 employees, large-scale reactors for vapor phase and liquid phase

catalytic and continuous processing • Largest worldwide Furan, MeTHF and Furfurylamine producer • Chemical expertise:

– Hydrogenation & Oxidations

– Furan chemistry

– Friedel & Craft substitutions

– Diels-Alder reactions

• R&D center • Managed by Pennakem

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Lacq: our sulfur expert

• With the support of Total and SOBEGI, Minafin has just implanted an R&D team spun-off from Minakem Research within Total’s R&D center at the Lacq site in September 2012

• Minathiol benefits from the extraordinary experience of TOTAL in processing volatile sulfur reagents for offering new fine chemicals with sulfur atoms

• Minathiol has access to SOBEGI’s pilot and industrial resources for commercial productions

• Chemical expertise: – H2S

– R-SH, R-S-R

– CSO

– Chiral reagents

• Managed by Minathiol

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Pittsburgh: our scale-up experts

• Pittsburgh for rapid scale-up (regulatory flexibility) of hazardous chemistries, new processes, and first commercial quantities for market introduction

• 41 employees, 33 m3 reaction volume • 10 Pilot and semi-works units, dedicated to low volume high value processing • Expansive range of experience in diverse chemistries • Chemical expertise:

– Hydrogenations – Polymerizations – High Pressure reactions

– Managed by Pressure Chemical

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Steady growth has been delivered since 2004

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Stakeholders recognize Minafin as a sustainable player in Fine Chemistry and trust its private ownership for long-term partnerships

Our latest acquisitions are fueling the organic growth of Minafin

The Priorities of the Minafin Group

• Keep developing its brands in accordance with its customers’ focus and needs

• Keep investing in R&D to develop its IP portfolio and differentiate from competitors

• Better integrating the peripheral know-how (solid properties, formulation, regulatory affairs) and offer full ranges of services

• Strengthening our position on the generic markets

• Targeting product technologies

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Merci de votre attention

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Minafin’s people keen to forge ahead