MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD.

Highlight Products: p62 and phospho-p62 ELISA Kits

Japan is getting cold and my favorite red scarf is keeping me warm Have you ever visited Japan? If you like winter sports, this is the place you should come!

Nov. 2017

vol.2

New & Renewal Website ・Epitope Tag Antibodies ・Autophagy ・Principle and method of the experiment

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 1

①Highlight Product:p62 and phospho-p62 ELISA Kits

3 ELISA kits were launched on May, 2017 !

CycLex® Total p62 ELISA Kit (code# CY-7055) https://www.mblbio.com/bio/g/dtl/P/?pcd=CY-7055

CycLex® Phospho-p62 Ser349 ELISA Kit (code# CY-7056) https://www.mblbio.com/bio/g/dtl/P/?pcd=CY-7056

CycLex® Phospho-p62 Ser403 ELISA Kit (code# CY-7057) https://www.mblbio.com/bio/g/dtl/P/?pcd=CY-7057

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 2

Features and benefits - The market’s first ELISA kit for phosphorylated p62!

- Comes with lysis buffer. Easy to prepare cell lysate!

- Useful for drug screening!

- Human and mouse cell lysate can be used.

- Same sample can be used for 3 kits.

Who will/might use them? Researchers who... - research on neurodegenerative disease and cancer

- do drug discovery related in autophagy in pharmaceutical companies

①Highlight Product: p62 and phospho-p62 ELISA Kits

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 3

Special notes

- Announced the new website for Autophagy field!https://www.mblbio.com/bio/g/product/autophagy/index.html

- Posted an article about p62 written by Dr. Masaaki Komatsu and

Dr. Yoshinobu Ichimura who are key opinion leaders on Autophagy in world wide https://www.mblbio.com/bio/g/product/autophagy/special-talk/p62.html

- These ELISA kits were evaluated by Dr. Masaaki Komatsu and

Dr. Yoshinobu Ichimura before these kits were launched.Visit to our web site!

①Highlight Product:p62 and phospho-p62 ELISA Kits

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 4

Products information

①Highlight Product: p62 and phospho-p62 ELISA Kits

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 5

Sales promotion materials

We prepared leaflet in October. Ask us for the editable PDF file!

http://ruo.mbl.co.jp/bio/e/literature/pdf/349203_p62ELISA.pdf

①Highlight Product: p62 and phospho-p62 ELISA Kits

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 6

Review of p62 and phospho-p62

What is p62 ?

p62/SQSTM1 is a scaffolding protein that interacts with various signaling molecules.

p62 contains an LC3-interacting region and is believed to be a substrate for selective autophagy.

In addition, p62 contains a domain that binds ubiquitin chains, and mediates the recruitment of poly

ubiquitinated protein aggregates and depolarized mitochondria to the autophagic machinery.

There is increasing interest about impairment of autophagic degradation in neurodegenerative

diseases (such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis),

alcoholic hepatitis, hepatic steatosis, and liver cancer.

Access the web site for the detail of p62.

https://www.mblbio.com/bio/g/product/autophagy/pickup/p62.html

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 7

What is phospho-p62 ? p62 has several phosphorylation sites. Two biophylaxis systems described below are effectively

activated by the continuous phosphorylation on these sites.

Impaired selective autophagy is implicated in various diseases. https://www.mblbio.com/bio/g/product/autophagy/pickup/phospho-p62.html

Review of p62 and phospho-p62

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 8

Want to Use Epitope Tag Antibodies?

Interested in Autophagy?

Need a Guide for Your Experiment?

Want to Know the Basic Principle and Method of the Experiment?

CHECK OUR RE-NEWED WEBSITE!!

②New & Renewal Website Now Available!

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 9

②New & Renewal WebsiteEpitope Tag Antibodies

“Examples of use” and “FAQ” are totally NEW! Click the contents to find out more information!

Our renewal website is much more easier to find what you want! https://www.mblbio.com/bio/g/product/tag/index.html

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 10

Not just the information about Autophagy, but you can also find the white papers written by the famous researchers of Autophagy! Whoever wants to try Autophagy, check our Website and learn more about Autophagy! https://www.mblbio.com/bio/g/product/autophagy/index.html

②New & Renewal WebsiteAutophagy

MEDICAL ＆ BIOLOGICAL LABORATORIES CO., LTD. 11

There are 4 categories you can check!

✔Antibody basics

✔Antibodies as a research tool

✔Qualitative and quantitative measurements of proteins using antibodies

✔Fractionation and purification of proteins

https://www.mblbio.com/bio/g/support/method/index.html

Help your experiments keep going! This can be a guide for people who are going to do an experiment for the first time as well!!

②New & Renewal WebsitePrinciple and method of the experiment